http://rdf.ncbi.nlm.nih.gov/pubchem/conserveddomain/PSSMID212834
Outgoing Links
| Predicate | Object |
|---|---|
| abstract | Second Src Homology 3 domain of Nck1 adaptor protein. Nck1 (also called Nckalpha) plays a crucial role in connecting signaling pathways of tyrosine kinase receptors and important effectors in actin dynamics and cytoskeletal remodeling. It binds and activates RasGAP, resulting in the downregulation of Ras. It is also involved in the signaling of endothilin-mediated inhibition of cell migration. Nck adaptor proteins regulate actin cytoskeleton dynamics by linking proline-rich effector molecules to protein tyrosine kinases and phosphorylated signaling intermediates. They contain three SH3 domains and a C-terminal SH2 domain. They function downstream of the PDGFbeta receptor and are involved in Rho GTPase signaling and actin dynamics. Vertebrates contain two Nck adaptor proteins: Nck1 (also called Nckalpha) and Nck2, which show partly overlapping functions but also bind distinct targets. The second SH3 domain of Nck appears to prefer ligands containing the APxxPxR motif. SH3 domains are protein interaction domains that usually bind to proline-rich ligands with moderate affinity and selectivity, preferentially a PxxP motif. They play versatile and diverse roles in the cell including the regulation of enzymes, changing the subcellular localization of signaling pathway components, and mediating the formation of multiprotein complex assemblies. |
| title | SH3_Nck1_2 |
| isDiscussedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/reference/20109180 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/4749202 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/28891908 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/22135810 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/14626783 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/24043821 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/14720988 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/20770852 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/8536154 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/25539867 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/7870172 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/21449974 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/25566098 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/9911965 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/13881394 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/18644445 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/23418158 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/19225940 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/32269087 |
| type | http://purl.obolibrary.org/obo/SO_0000417 |
Incoming Links
| Predicate | Subject |
|---|---|
| has component | http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP16333 http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCNP_006144 http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ99M51 |
Total number of triples: 25.