http://rdf.ncbi.nlm.nih.gov/pubchem/conserveddomain/PSSMID206713
Outgoing Links
| Predicate | Object |
|---|---|
| abstract | Ras-related and Estrogen-Regulated Growth inhibitor (RERG) and Ras-like 11 (RasL11)-like families. RERG (Ras-related and Estrogen- Regulated Growth inhibitor) and Ras-like 11 are members of a novel subfamily of Ras that were identified based on their behavior in breast and prostate tumors, respectively. RERG expression was decreased or lost in a significant fraction of primary human breast tumors that lack estrogen receptor and are correlated with poor clinical prognosis. Elevated RERG expression correlated with favorable patient outcome in a breast tumor subtype that is positive for estrogen receptor expression. In contrast to most Ras proteins, RERG overexpression inhibited the growth of breast tumor cells in vitro and in vivo. RasL11 was found to be ubiquitously expressed in human tissue, but down-regulated in prostate tumors. Both RERG and RasL11 lack the C-terminal CaaX prenylation motif, where a = an aliphatic amino acid and X = any amino acid, and are localized primarily in the cytoplasm. Both are believed to have tumor suppressor activity. |
| title | RERG_RasL11_like |
| isDiscussedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/reference/2969109 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/26787741 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/15217862 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/25401399 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/23307261 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/921760 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/5688382 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/17246008 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/25382530 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/21344573 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/15210038 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/7793672 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/1648951 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/11188059 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/21988444 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/27408002 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/7806980 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/5717406 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/24010022 |
| type | http://purl.obolibrary.org/obo/SO_0000417 |
Incoming Links
Total number of triples: 43.