http://rdf.ncbi.nlm.nih.gov/pubchem/conserveddomain/PSSMID206664
Outgoing Links
| Predicate | Object |
|---|---|
| abstract | cell division cycle 42 (Cdc42) is a small GTPase of the Rho family. Cdc42 is an essential GTPase that belongs to the Rho family of Ras-like GTPases. These proteins act as molecular switches by responding to exogenous and/or endogenous signals and relaying those signals to activate downstream components of a biological pathway. Cdc42 transduces signals to the actin cytoskeleton to initiate and maintain polarized growth and to mitogen-activated protein morphogenesis. In the budding yeast Saccharomyces cerevisiae, Cdc42 plays an important role in multiple actin-dependent morphogenetic events such as bud emergence, mating-projection formation, and pseudohyphal growth. In mammalian cells, Cdc42 regulates a variety of actin-dependent events and induces the JNK/SAPK protein kinase cascade, which leads to the activation of transcription factors within the nucleus. Cdc42 mediates these processes through interactions with a myriad of downstream effectors, whose number and regulation we are just starting to understand. In addition, Cdc42 has been implicated in a number of human diseases through interactions with its regulators and downstream effectors. Most Rho proteins contain a lipid modification site at the C-terminus, with a typical sequence motif CaaX, where a = an aliphatic amino acid and X = any amino acid. Lipid binding is essential for membrane attachment, a key feature of most Rho proteins. Due to the presence of truncated sequences in this CD, the lipid modification site is not available for annotation. |
| title | Cdc42 |
| isDiscussedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/reference/230139 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/20582584 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/26794279 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/5665470 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/24760715 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/25391643 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/196917 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/26134741 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/23958929 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/24014779 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/24665199 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/30065918 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/16515082 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/9753752 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/32751999 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/27483335 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/26801953 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/19227424 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/27395124 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/11227381 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/32767166 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/21912856 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/17970667 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/2331212 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/18007632 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/8404913 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/21966527 |
| type | http://purl.obolibrary.org/obo/SO_0000417 |
Incoming Links
Total number of triples: 45.