http://rdf.ncbi.nlm.nih.gov/pubchem/conserveddomain/PSSMID198276
Outgoing Links
| Predicate | Object |
|---|---|
| abstract | Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 7 (Grb7) proteins. The Grb family binds to the epidermal growth factor receptor (EGFR, erbB1) via their SH2 domains. Grb7 is part of the Grb7 family of proteins which also includes Grb10, and Grb14. They are composed of an N-terminal Proline-rich domain, a Ras Associating-like (RA) domain, a Pleckstrin Homology (PH) domain, a phosphotyrosine interaction region (PIR, BPS) and a C-terminal SH2 domain. The SH2 domains of Grb7, Grb10 and Grb14 preferentially bind to a different RTK. Grb7 binds strongly to the erbB2 receptor, unlike Grb10 and Grb14 which bind weakly to it. Grb7 family proteins are phosphorylated on serine/threonine as well as tyrosine residues. In general SH2 domains are involved in signal transduction. They typically bind pTyr-containing ligands via two surface pockets, a pTyr and hydrophobic binding pocket, allowing proteins with SH2 domains to localize to tyrosine phosphorylated sites. |
| title | SH2_Grb7 |
| isDiscussedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/reference/10471184 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/30245533 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/9111237 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/19225940 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/18604561 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/14024896 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/4057825 |
| type | http://purl.obolibrary.org/obo/SO_0000417 |
Incoming Links
Total number of triples: 15.