conserveddomain/PSSMID197357

Predicate	Object
abstract	C-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins. Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).
title	Reelin_repeat_5_subrepeat_2
isDiscussedBy	http://rdf.ncbi.nlm.nih.gov/pubchem/reference/2986799 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/24688243 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/24804873 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/21381981 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/27406354 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/12002366
type	http://purl.obolibrary.org/obo/SO_0000417

Predicate	Subject
has component	http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ60841 http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP78509 http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP58751

Total number of triples: 12.