http://rdf.ncbi.nlm.nih.gov/pubchem/conserveddomain/PSSMID188973
Outgoing Links
Predicate | Object |
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abstract | SAM domain of STIM2 subfamily proteins. SAM (sterile alpha motif) domain of STIM2 (Stromal interaction molecule) subfamily proteins is a putative protein-protein interaction domain. STIM1 and STIM2 human proteins are type I transmembrane proteins. The N-terminal part of them includes "hidden" EF-hand and SAM domains. This region is responsible for sensing changes in store-operated and basal cytoplasmic Ca2+ levels and initiates oligomerization. "Hidden" EF hand and SAM domains have a stable intramolecular association, and the SAM domain is a component that regulates stability within STIM proteins. Destabilization of the EF-SAM association during Ca2+ depletion leads to partial unfolding and aggregation (homooligomerization), thus activating the store-operated Ca2+ entry. Immunoprecipitation analysis indicates that STIM1 and STIM2 can form co-precipitable oligomeric associations in vivo. It was suggested that STIM2 protein is an inhibitor of store operated channels in plasma membrane. |
title | SAM_STIM2 |
isDiscussedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/reference/28831100 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/24776229 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/21384165 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/28836831 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/5157046 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/1723260 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/26722203 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/16717610 |
type | http://purl.obolibrary.org/obo/SO_0000417 |
Incoming Links
Predicate | Subject |
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has component | http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ9P246 http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP83093 |
Total number of triples: 13.