http://rdf.ncbi.nlm.nih.gov/pubchem/conserveddomain/PSSMID188921
Outgoing Links
| Predicate | Object |
|---|---|
| abstract | SAM domain of SLP76 subfamily. SAM (sterile alpha motif) domain of SLP76 (SH2 domain-containing leukocyte protein 76), also known as LCP2 (Lymphocyte cytosolic protein), subfamily is a protein-protein interaction domain. Proteins of this group have an N-terminal SAM domain, 3 phosphotyrosine motifs, a proline-rich region and a C-terminal SH2 domain. They are scaffold proteins involved in protein complex formation. The complexes play a role in T-cell receptor mediated signaling pathways such as integrin activation, cytoskeletal organization, MARK activation, and calcium flux. SAM domain deleted SLP76 knockin mice show a number of defects, including partially blocked thymocyte development, impaired positive and negative thymic selection and changes in T-cell receptor mediated signaling. |
| title | SAM_SLP76 |
| isDiscussedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/reference/11296695 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/17228735 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/26151209 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/8573160 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/5157046 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/24776229 |
| type | http://purl.obolibrary.org/obo/SO_0000417 |
Incoming Links
| Predicate | Subject |
|---|---|
| has component | http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ13094 http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ60787 |
Total number of triples: 11.