http://rdf.ncbi.nlm.nih.gov/pubchem/conserveddomain/PSSMID188871
Outgoing Links
| Predicate | Object |
|---|---|
| abstract | The second LIM domain of Cysteine Rich Protein 2 (CRP2). The second LIM domain of Cysteine Rich Protein 2 (CRP2): Cysteine-rich proteins (CRPs) are characterized by the presence of two LIM domains linked to short glycine-rich repeats (GRRs). The CRP family members include CRP1, CRP2, CRP3/MLP and TLPCRP1, CRP2 and CRP3 share a conserved nuclear targeting signal (K/R-K/R-Y-G-P-K), which supports the fact that these proteins function not only in the cytoplasm but also in the nucleus. CRPs control regulatory pathways during cellular differentiation, and involve in complex transcription circuits, and the organization as well as the arrangement of the myofibrillar/cytoskeletal network.CRP3 also called Muscle LIM Protein (MLP), which is a striated muscle-specific factor that enhances myogenic differentiation. The second LIM domain of CRP3/MLP interacts with cytoskeletal protein beta-spectrin. CRP3/MLP also interacts with the basic helix-loop-helix myogenic transcription factors MyoD, myogenin, and MRF4 thereby increasing their affinity for specific DNA regulatory elements. LIM domains are 50-60 amino acids in size and share two characteristic zinc finger motifs. The two zinc fingers contain eight conserved residues, mostly cysteines and histidines, which coordinately bond to two zinc atoms. LIM domains function as adaptors or scaffolds to support the assembly of multimeric protein complexes. |
| title | LIM2_CRP2 |
| isDiscussedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/reference/4939642 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/21995544 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/26772543 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/5792562 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/18680030 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/1012306 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/25364402 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/27357395 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/16486584 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/17159383 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/2910897 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/32761684 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/3643880 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/4973514 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/16506366 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/28700720 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/6353164 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/23244266 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/23281369 |
| type | http://purl.obolibrary.org/obo/SO_0000417 |
Incoming Links
Total number of triples: 28.