http://rdf.ncbi.nlm.nih.gov/pubchem/conserveddomain/PSSMID188866

Outgoing Links

Predicate Object
abstract The second LIM domain of Cysteine Rich Protein 3 (CRP3/MLP). The second LIM domain of Cysteine Rich Protein 3 (CRP3/MLP): Cysteine-rich proteins (CRPs) are characterized by the presence of two LIM domains linked to short glycine-rich repeats (GRRs). The CRP family members include CRP1, CRP2, CRP3/MLP and TLPCRP1, CRP2 and CRP3 share a conserved nuclear targeting signal (K/R-K/R-Y-G-P-K), which supports the fact that these proteins function not only in the cytoplasm but also in the nucleus. CRPs control regulatory pathways during cellular differentiation, and involve in complex transcription circuits, and the organization as well as the arrangement of the myofibrillar/cytoskeletal network.CRP3 also called Muscle LIM Protein (MLP), which is a striated muscle-specific factor that enhances myogenic differentiation. The second LIM domain of CRP3/MLP interacts with cytoskeletal protein beta-spectrin. CRP3/MLP also interacts with the basic helix-loop-helix myogenic transcription factors MyoD, myogenin, and MRF4 thereby increasing their affinity for specific DNA regulatory elements. LIM domains are 50-60 amino acids in size and share two characteristic zinc finger motifs. The two zinc fingers contain eight conserved residues, mostly cysteines and histidines, which coordinately bond to two zinc atoms. LIM domains function as adaptors or scaffolds to support the assembly of multimeric protein complexes.
title LIM2_CRP3
isDiscussedBy http://rdf.ncbi.nlm.nih.gov/pubchem/reference/4973514
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/30218649
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/6353164
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/21995544
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/25364402
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/23244266
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/26772543
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/27357395
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/4748338
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/18680030
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/16506366
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/17159383
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/4939642
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/2930258
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/1012306
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/3643880
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/23281369
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/16486584
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/28700720
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/5792562
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/32761684
type http://purl.obolibrary.org/obo/SO_0000417

Incoming Links

Predicate Subject
has component http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ4U0T9
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP50461
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP50462

Total number of triples: 27.