http://rdf.ncbi.nlm.nih.gov/pubchem/conserveddomain/PSSMID188670

Outgoing Links

Predicate Object
abstract Regulator of G protein signaling (RGS) domain found in the RGS1 protein. The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS1 protein. RGS1 is a member of the R4/RGS subfamily of the RGS family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha subunits. The RGS domain controls G-protein signaling by accelerating the GTPase activity of the G-alpha subunit which leads to G protein deactivation and promotes desensitization. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS 1 is expressed predominantly in hematopoietic compartments, including T and B lymphocytes, and may play a major role in chemokine-mediated homing of lymphocytes to secondary lymphoid organs. In addition, RGS1 interacts with calmodulin and 14-3-3 protein outside of the GPCR pathway.
title RGS_RGS1
isDiscussedBy http://rdf.ncbi.nlm.nih.gov/pubchem/reference/10408104
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/32218536
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/33544704
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/1531690
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/15956963
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/6419792
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/16026630
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/33379455
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/6346559
type http://purl.obolibrary.org/obo/SO_0000417

Incoming Links

Predicate Subject
has component http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ6RG78
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ08116

Total number of triples: 14.