http://rdf.ncbi.nlm.nih.gov/pubchem/conserveddomain/PSSMID176880

Outgoing Links

Predicate Object
abstract Lipid-binding START domain of mammalian STARD10 and related proteins. This subfamily includes the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domains of mammalian STARD10 (also known as CGI-52, PTCP-like, and SDCCAG28). The START domain family belongs to the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket. STARD10 binds phophatidylcholine and phosphatidylethanolamine. This protein is widely expressed and is synthesized constitutively in many organs. It may function in the liver in the export of phospholipids into bile. It is concentrated in the sperm flagellum, and may play a role in energy metabolism. In the mammary gland it may participate in the enrichment of lipids in milk, and be a potential marker of differentiation. Its expression is induced in this gland during gestation and lactation. It is overexpressed in mammary tumors from Neu/ErbB2 transgenic mice, in several breast carcinoma cell lines, and in 35% of primary human breast cancers, and may cooperate with c-erbB receptor signaling in breast oncogenesis. It is a potential marker of disease outcome in breast cancer; loss of STARD10 expression in breast cancer strongly predicts an aggressive disease course. The lipid transfer activity of STRAD10 is downregulated by phosphorylation of its Ser284 by CK2 (casein kinase 2).
title START_STARD10-like
isDiscussedBy http://rdf.ncbi.nlm.nih.gov/pubchem/reference/3604784
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/9202525
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/11993530
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/4982358
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/25537531
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/33418980
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/24168570
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/21271545
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/27412698
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/15344055
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/2326503
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/24760481
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/15278924
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/15975541
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/26188205
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/22618670
type http://purl.obolibrary.org/obo/SO_0000417

Incoming Links

Predicate Subject
has component http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ9JMD3
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ9Y365

Total number of triples: 21.