http://rdf.ncbi.nlm.nih.gov/pubchem/conserveddomain/PSSMID143540
Outgoing Links
| Predicate | Object |
|---|---|
| abstract | DNA-binding domain of REV-ERB receptor-like is composed of two C4-type zinc fingers. DNA-binding domain of REV-ERB receptor- like is composed of two C4-type zinc fingers. Each zinc finger contains a group of four Cys residues which coordinates a single zinc atom. This domain interacts with specific DNA sites upstream of the target gene and modulates the rate of transcriptional initiation. REV-ERB receptors are transcriptional regulators belonging to the nuclear receptor superfamily. They regulate a number of physiological functions including the circadian rhythm, lipid metabolism, and cellular differentiation. REV-ERB receptors bind as a monomer to a (A/G)GGTCA half-site with a 5' AT-rich extension or as a homodimer to a direct repeat 2 element (AGGTCA sequence with a 2-bp spacer), indicating functional diversity. When bound to the DNA, they recruit corepressors (NcoR/histone deacetylase 3) to the promoter, resulting in repression of the target genes. The porphyrin heme has been demonstrated to function as a ligand for REV-ERB receptor. Like other members of the nuclear receptor (NR) superfamily of ligand-activated transcription factors, REV-ERB receptors have a central well conserved DNA binding domain (DBD), a variable N-terminal domain, a non-conserved hinge and a C-terminal ligand binding domain (LBD). |
| title | NR_DBD_REV_ERB |
| isDiscussedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/reference/5792568 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/20702094 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/3615712 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/31528866 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/15904987 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/30888579 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/33572220 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/5821063 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/21349480 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/26847359 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/21349483 |
| type | http://purl.obolibrary.org/obo/SO_0000417 |
Incoming Links
Total number of triples: 20.