http://rdf.ncbi.nlm.nih.gov/pubchem/conserveddomain/PSSMID133330
Outgoing Links
| Predicate | Object |
|---|---|
| abstract | Wnt-1 responsive Cdc42 homolog (Wrch-1) is a Rho family GTPase similar to Cdc42. Wrch-1 (Wnt-1 responsive Cdc42 homolog) is a Rho family GTPase that shares significant sequence and functional similarity with Cdc42. Wrch-1 was first identified in mouse mammary epithelial cells, where its transcription is upregulated in Wnt-1 transformation. Wrch-1 contains N- and C-terminal extensions relative to cdc42, suggesting potential differences in cellular localization and function. The Wrch-1 N-terminal extension contains putative SH3 domain-binding motifs and has been shown to bind the SH3 domain-containing protein Grb2, which increases the level of active Wrch-1 in cells. Unlike Cdc42, which localizes to the cytosol and perinuclear membranes, Wrch-1 localizes extensively with the plasma membrane and endosomes. The membrane association, localization, and biological activity of Wrch-1 indicate an atypical model of regulation distinct from other Rho family GTPases. Most Rho proteins contain a lipid modification site at the C-terminus, with a typical sequence motif CaaX, where a = an aliphatic amino acid and X = any amino acid. Lipid binding is essential for membrane attachment, a key feature of most Rho proteins. Due to the presence of truncated sequences in this CD, the lipid modification site is not available for annotation. |
| title | Wrch_1 |
| isDiscussedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/reference/22696494 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/8404913 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/230139 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/21966527 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/24665199 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/26718858 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/32751999 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/23958929 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/16515082 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/17970667 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/196917 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/20582584 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/27395124 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/30065918 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/21912856 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/24014779 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/25391643 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/19227424 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/9753752 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/32767166 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/24079327 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/5665470 |
| type | http://purl.obolibrary.org/obo/SO_0000417 |
Incoming Links
Total number of triples: 32.