http://rdf.ncbi.nlm.nih.gov/pubchem/conserveddomain/PSSMID132980
Outgoing Links
| Predicate | Object |
|---|---|
| abstract | Catalytic domain of the dual-specificity Protein Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase 2. PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (ST) or tyrosine residues on protein substrates. MEK2 is a dual-specificity PK and a MAPK kinase (MAPKK or MKK) that phosphorylates and activates the downstream targets, ERK1 and ERK2, on specific threonine and tyrosine residues. The ERK cascade starts with extracellular signals including growth factors, hormones, and neurotransmitters, which act through receptors and ion channels to initiate intracellular signaling that leads to the activation at the MAPKKK (Raf-1 or MOS) level, which leads to the transmission of signals to MEK2, and finally to ERK1/2. The ERK cascade plays an important role in cell proliferation, differentiation, oncogenic transformation, and cell cycle control, as well as in apoptosis and cell survival under certain conditions. Gain-of-function mutations in genes encoding ERK cascade proteins, including MEK2, cause cardiofaciocutaneous (CFC) syndrome, a condition leading to multiple congenital anomalies and mental retardation in patients. The MEK subfamily is part of a larger superfamily that includes the catalytic domains of other protein serine/threonine kinases, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase. |
| title | PKc_MEK2 |
| isDiscussedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/reference/29509028 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/17295342 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/1033537 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/2329714 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/16682471 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/19353944 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/17964166 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/23418494 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/25135326 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/32174543 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/15901001 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/3749075 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/28107692 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/30174902 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/19994299 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/8525039 |
| type | http://purl.obolibrary.org/obo/SO_0000417 |
Incoming Links
Total number of triples: 24.