http://rdf.ncbi.nlm.nih.gov/pubchem/conserveddomain/PSSMID119368
Outgoing Links
| Predicate | Object |
|---|---|
| abstract | CIDE_N domain of CAD nuclease. The CIDE_N (cell death-inducing DFF45-like effector, N-terminal) domain is found at the N-terminus of CAD nuclease (caspase-activated DNase/DNA fragmentation factor, DFF40) and its inhibitor, ICAD(DFF45). These proteins are associated with the chromatin condensation and DNA fragmentation events of apoptosis; the CIDE_N domain is thought to regulate the activity of CAD/DFF40 and ICAD/DFF45 during apoptosis. In normal cells, DFF exists in the nucleus as a heterodimer composed of CAD/DFF40 as a latent nuclease and its chaperone and inhibitor subunit ICAD/DFF45. Apoptotic activation of caspase-3 results in the cleavage of DFF45/ICAD and the release of active DFF40/CAD nuclease. |
| title | CIDE_N_CAD |
| isDiscussedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/reference/9200476 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/20566684 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/8477423 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/20566691 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/17363936 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/11116263 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/22000597 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/33440491 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/11809036 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/16549961 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/32158587 |
| type | http://purl.obolibrary.org/obo/SO_0000417 |
Incoming Links
| Predicate | Subject |
|---|---|
| has component | http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCO54788 http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ99N34 http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCO76075 |
Total number of triples: 17.