http://rdf.ncbi.nlm.nih.gov/pubchem/author/MD5_ee782b70a0d45ca3cbe6691153be9285
Outgoing Links
Predicate | Object |
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family-name | Jian Huang Huang |
name | Jian Huang |
given-name | Jian |
organization-name | Department of Stomatology, Longhu People's Hospital of Shantou, Shantou 515041, China. Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education), Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310012, China. Department of Oral and Maxillofacial Surgery, Fujian Provincial Hospital, 134 Dongjie, Fuzhou, China Departments of Statistics and Actuarial Science, University of Iowa, Iowa City, IA, U.S.A. Department of Chemistry, Fudan University, Shanghai, 200433, Peoples Republic of China Department of Clinical Medicine, Grade 2001, Guangxi Medical University, Nanning, China Department of Cardiology, The Second Affiliated Hospital of Soochow University, Suzhou, China Department of Urology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangdong Provincial Clinical Research Center for Urological Diseases, Guangzhou, Guangdong 510120, China Department of Statistics and Actuarial Science, University of Iowa, USA Chinese Academy of Sciences; Advanced Laser Technology Laboratory of Anhui Province Liver Unit, Division of Digestive Diseases, Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, London W21NY, UK Department of Urology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, PR China; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, PR China College of Physics Science and Technology; Kunming University; Kunming; China From the Lester and Sue Smith Breast Center, Dan L. Duncan Cancer Center, Baylor College of Medicine; Methodist Hospital, Houston, TX; and Vanderbilt University, Nashville, TN. Department of Dermatology Third Xiangya Hospital Central South University Changsha China Institute of Desert and Meteorology China Meteorological Administration Urumqi China; Central Asian Research Center of Atmospheric Sciences Urumqi China State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, China Department of Urology, Second Affiliated Hospital, Sun Yat-sen University, Guangzhou 510120, China. yehjn@yahoo.com.cn T3 Bioscience, Lapham Hall 181, Milwaukee, WI 53211 Department of Obstetrics, The second Xiangya Hospital, Central South University , Changsha 410011 , People’s Republic of China Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Guangdong Medical University, 523808 Dongguan, China; Department of Pediatrics, University of Miami Miller School of Medicine, Miami, Florida; Batchelor Children’s Research Institute, University of Miami Miller School of Medicine, Miami, Florida Beijing University of Chinese Medicine, Beijing, China Department of Orthopaedics and Rehabilitation and Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, New York, USA Department of Oncology, The Second Hospital Affiliated to Medical College of Zhejiang University, Hangzhou. hjys@zju.edu.cn State Key Laboratory of Inorganic Synthesis & Preparative Chemistry, Jilin University, 2699 Qianjin Street, 130012 Changchun, P. R. China Jiangsu Provincial Key Lab of Solid Organic Waste Utilization, Jiangsu Collaborative Innovation Center of Solid Organic Wastes, Educational Ministry Engineering Center of Resource‐Saving Fertilizers Nanjing Agricultural University Nanjing China Department of Neurology, the First Affiliated Hospital of Gannan Medical University, Ganzhou, China Coriell Institue for Medical Research Department of Cardiac Surgery, Shandong Provincial Key Laboratory of Cardiac Disease Diagnosis and Treatment, Affiliated Hospital of Jining Medical University, Jining, Shandong, China Department of Anatomy and Neurobiology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, Guangdong, China (mainland) The Third Department of Hepatic Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Naval Medical University, Shanghai, China Department of Chemistry School of Pharmaceutical Sciences Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education) Beijing Advanced Innovation Center for Structural Biology Tsinghua-Peking Joint Center for Life Sciences Tsinghua University Beijing 100084 P. R. China Chinese Center for Disease Control and Prevention National Institute for Nutrition and Health , Beijing , China Department of Medicinal Chemistry and Natural Medicine Chemistry (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China), Harbin Medical University, Harbin 150081, China School of Forensic Medicine, Kunming Medical University, 1168 West Chunrong Road, Yuhua Avenue Chenggong District, Kunming, Yunnan 650500, China Department of Orthopaedics and Rehabilitation, Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, New York 14642, USA Department of Urology Sun Yat‐sen Memorial Hospital Guangzhou Guangdong P. R. China; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Sun Yat‐sen Memorial Hospital State Key Laboratory of Oncology in South China Guangzhou Guangdong P. R. China Department of Biochemistry and Molecular Biology, School of Medicine, Shanghai Jiaotong University, Shanghai 200025. hj1970@hotmail.com 1Laboratory of Molecular Immunoregulation, Cancer and Inflammation Program, Center for Cancer Research and School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, China;; Department of Medicinal Chemistry and Natural Medicine Chemistry (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China), Harbin Medical University, Harbin, P. R. China School of Traditional Chinese Medicines, Shenyang Pharmaceutical University, Shenyang 110016, China Department of Biochemistry and Molecular Biology, Shanghai Jiaotong University, School of Medicine, Shanghai 200025. hj1970@hotmail.com Department of Urology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, People's Republic of China Department of Oncology, the Second Affiliated Hospital, School of Medicine, Zhejiang University Beijing Institute of Radiation Medicine, Beijing 100850, China.; Shenzhen YiShengTang Biology Medicine Ltd, Shenzhen 518026, China; Hangzhou Sixth Hospital, Hangzhou 310000, China; Hangzhou Zhiyuan Laboratory Medicine Research Institute, Hangzhou 310009, China Laboratory of Molecular Immunoregulation, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, MD 21702, USA. Statistics and Actuarial Science and the Cancer Institute (Key Laboratory of Cancer Prevention & Intervention, National Ministry of Education, Provincial Key Laboratory of Molecular Biology in Medical Sciences), The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China; Department of Oncology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China. Electronic address: drhuangjian@zju.edu.cn. Department of Statistics Medtronic, plc Minneapolis MN Department of Obstetrics and Gynecology, Second Xiangya Hospital, Central South University, Changsha 410011, China. Key Laboratory for Liquid−Solid Structural Evolution and Processing of Materials, Ministry of Education, Shandong University, Jinan 250061, China Experimental Centre, Beijing Friendship Hospital, Capital Medical University, Beijing, PR China. huangj1966@hotmail.com. The Fourth Department of Medical Oncology Harbin Medical University Cancer Hospital Harbin Heilongjiang China Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY, USA Department of Pathology Affiliated Hospital of Guangdong Medical University Zhanjiang China Department of Statistics and Actuarial Science, Iowa University, Iowa City, IA Department of Orthopedic Surgery Rush University Medical Center Chicago Illinois USA College of Environment & Safety Engineering, Fuzhou University, Fuzhou 350108, China Biodemography of Aging Research Unit Social Science Research Institute Duke University Durham North Carolina Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Department of Natural Products Chemistry, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, People’s Republic of China Department of Hematology, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China Key Laboratory for Green Chemistry of Jiangxi Province, Key Laboratory of Functional Small Molecules for Ministry of Education, Jiangxi Normal University Key Laboratory of Tumor Microenvironment and Immune Therapy of Zhejiang Province, Hangzhou, Zhejiang 310009, China; Department of Breast Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, China. Institute of Hepatology, Shenzhen Third People’s Hospital, Guangdong Medical College, Shenzhen, China Shanghai-MOST Key Laboratory for Disease and Health Genomics, Chinese National Human Genome Center and National Engineering Center for Biochip at Shanghai, Shanghai, China; Key Laboratory of Systems Biomedicine (Ministry of Education) and Collaborative Innovation Center of Systems Biomedicine, Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, China Department of Breast Surgery, Key Laboratory of Tumor Microenvironment and Immune Therapy of Zhejiang Province, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, China. From the Coronary Artery Disease Research Group, Department of Cardiological Sciences, St George’s Hospital Medical School, London, England. Department of Urology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China Bioinformatics Center; School of Life Science; University of Electronic Science and Technology of China; Chengdu, China Department of Materials Science and Engineering Collaborative Innovation Center of Chemistry for Energy Materials College of Materials Xiamen University Xiamen 361005 China Department of Gastroenterology, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, Guangdong 518033, China Department of Breast Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, China; Key Laboratory of Tumor Microenvironment and Immune Therapy of Zhejiang Province, Hangzhou, Zhejiang 310009, China MRC Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health Imperial College London London UK Department of Urology Sun Yat‐sen Memorial Hospital Sun Yat‐sen University Guangzhou Guangdong 510120 P. R. China; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Sun Yat‐Sen Memorial Hospital Sun Yat‐Sen University Guangzhou Guangdong 510120 P. R. China; State Key Laboratory of Oncology in South China Guangzhou Guangdong 510120 P. R. China MRC Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK Public Center of Experimental Technology, School of Basic Medical Sciences, Southwest Medical University, Luzhou 646000, China National Engineering Center for Biochip at Shanghai, Shanghai, China; Shanghai-MOST Key Laboratory for Disease and Health Genomics, Chinese National Human Genome Center at Shanghai, Shanghai, China; Key Laboratory of Systems Biomedicine (Ministry of Education) and Collaborative Innovation Center of Systems Biomedicine, Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, China Department of Pulmonary Oncology Affiliated Hospital of Guangdong Medical University Zhanjiang China Singapore Institute for Clinical Sciences (SICS), Agency for Science, Technology and Research (A*STAR) Department of Urology, Second Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510120, China. yehjn@yahoo.com.cn The Platform of Molecular Biotechnology, Public Center of Experimental Technology, School of Basic Medical Sciences, Southwest Medical University, Luzhou, People’s Republic of China Department of Biochemistry and Molecular Cell Biology & Shanghai Key Laboratory of Tumor Microenvironment and Inflammation, Shanghai Jiao Tong University School of Medicine, Shanghai, China Department of Critical Care Medicine, Hangzhou Ninth People’s Hospital, Hangzhou, China Laboratory of Extracorporeal Life Support Lanzhou University Second Hospital, Lanzhou University Lanzhou China; Department of Cardiac Surgery Lanzhou University Second Hospital, Lanzhou University Lanzhou China Viral Oncology Program, Sidney Kimmel Cancer Center; Department of Pharmacology and Molecular Sciences, Johns Hopkins School of Medicine, Baltimore, Maryland 21231 Key Laboratory of High Altitude Medicine, Ministry of Education, Chongqing, People's Republic of China.; Department of Pathophysiology and High Altitude Physiology, College of High Altitude Military Medicine, Third Military Medical University, Chongqing, People's Republic of China. College of Forestry, Northwest A&F University, Yangling, China Department of Breast Surgery Second Affiliated Hospital of Zhejiang University Hangzhou China; Key Laboratory of Tumor Microenvironment and Immune Therapy of Zhejiang Province Hangzhou China Department of Laboratory Medicine, Affiliated Hospital of Zunyi Medical University, Guizhou, China Department of Pathology, 1 Baylor Plaza, Baylor College of Medicine, Houston, Texas 77030 State Key Laboratory of High Performance Ceramics and Superfine Microstructures Shanghai Institute of Ceramics Chinese Academy of Sciences Shanghai 200050 P. R. China Authors' Affiliations: 1National Human Genome Center, Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine; 2Shanghai-MOST Key Laboratory for Disease and Health Genomics, Chinese National Human Genome Center at Shanghai, Shanghai, China Trauma Center & ICU, Daping Hospital & Research Institute of Surgery, Third Military Medical University, Chongqing 400042, China Key Laboratory of Diagnostic Medicine (Ministry of Education), College of Laboratory Medicine, Chongqing Medical University, Chongqing, China; Department of Laboratory Medicine, The First Affiliated Hospital, Zunyi Medical College, Zunyi, China Department of Biochemistry and Molecular Cell Biology; Shanghai Key Laboratory of Tumor Microenvironment and Inflammation; Shanghai Jiao Tong University School of Medicine; Shanghai China From the Key Laboratory of Arrhythmias of the Ministry of Education of China, East Hospital, Tongji University School of Medicine (J.L., D.X., J.H., F.L., D.S., Y.L., L.L., L.G., Y.W., D.L., Y.-H.C.); Institute of Medical Genetics, Tongji University (J.L., D.S., Y.L., L.L., D.L., Y.-H.C.); Research Center for Translational Medicine, East Hospital, Tongji University School of Medicine (J.L., D.S., Y.L., L.L., D.L., Y.-H.C.); Department of Cardiology, East Hospital, Tongji University School of... Department of Pathology and Laboratory Medicine Temple University School of Medicine, Philadelphia, Pennsylvania, USA State Key Laboratory of Rare Earth Materials Chemistry and Applications, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China Department of Andrology, Jiangsu Provincial Hospital of Traditional Chinese Medicine, Nanjing, Jiangsu 210029, China. a Jiangsu Provincial Environmental Engineering Technology Co., Ltd, Engineering Research Center of Standardized Construction and Intelligent Management of Industrial Parks, Jiangsu Province Engineering Research Center of Standardized Construction and Intelligent Management of Industrial Parks, Nanjing 210036, China Beijing Key Laboratory of Translational Medicine in Liver Cirrhosis & National Clinical Research Center of Digestive Diseases Beijing China Department of Pediatrics, University of Miami Miller School of Medicine , Miami, FL , USA; Batchelor Children’s Research Institute, University of Miami Miller School of Medicine , Miami, FL , USA Department of Applied Mathematics The Hong Kong Polytechnic University Hung Hom Kowloon Hong Kong The Fourth Affiliated Hospital of Zhejiang University School of Medicine, Zhejiang, China Center for Informational Biology, University of Electronic Science and Technology of China, No. 2006, Xiyuan Ave, West Hi-Tech Zone, Chengdu 611731, China Institute of Respiratory Diseases, First Affiliated Hospital, Guangxi Medical University, Nanning, China. Department of Obstetrics and Gynecology, The First People's Hospital of Hangzhou Hangzhou, China. The Univ. of Alabama at Birmingham College of Life Sciences; Fujian Normal University; Fuzhou 350117; China; Engineering Research Center of Industrial Microbiology Department of Clinical Laboratory The First Affiliated Hospital of Guangxi Medical University Nanning China Department of Statistics and Actuarial Science, University of Iowa, Iowa City, Ia., U.S.A. College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China, and Beijing Institute of Radiation Medicine, Beijing 100850, China Department of Emergency Medicine, The First affiliated Hospital of Soochow University, Suzhou, China Department of Physiology University of Texas Southwestern Medical Center Dallas TX 75390 USA Department of Physiology Reproduction, Medical College of Nanchang University, USA. School of Mechanical and Automotive Engineering, South China University of Technology, Guangzhou, China State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, People's, China 6Coriell Institute for Medical Research, Camden, New Jersey. Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan Key Laboratory for Liquid-Solid Structural Evolution and Processing of Materials Ministry of Education Shandong University Jinan 250061 P. R. China From the Departments of Medicine (J.H., J.M.R., C.R.K., G.P.W., W.M.S., R.E.I.), Biomedical Engineering (J.M.R., W.M.S., R.E.I.), and Physiology (R.E.I.), University of Alabama at Birmingham, and Guidant Corp (B.H.K.), St. Paul, Minn. Department of Cardiac Surgery, Lanzhou University Second Hospital, Lanzhou, China a School of Traditional Chinese Medicines, Shenyang Pharmaceutical University , Shenyang, 110016, China Department of Hepatic Surgery (III), The Third Affiliated Hospital of Naval Medical University, Shanghai, China Department of Gastroenterology Yuyao People’s Hospital of Zhejiang Province Ningbo China Cardiac Rhythm Management Laboratory, Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, AL Department of BiochemistryRush University Medical CenterChicagoILUSA School of Forensic Medicine, Kunming Medical University, 1168 West Chunrong Road, Yuhua Avenue Chenggong, Kunming, Yunnan 650500, China; School of Forensic Medicine, Southern Medical University, 1838 Guangzhou Dadao Bei, Baiyun District, Guangzhou 510515, Guangdong, China School of Modern Industry for Selenium Science and Engineering, Wuhan Polytechnic University, Wuhan 430023, China; College of Food Science and Engineering, Wuhan Polytechnic University, Wuhan 430023, China Departments of Statistics and Actuarial Science, and Biostatistics University of Iowa Iowa City Iowa United States of America State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China Guangdong Provincial Key Laboratory of Malignant Tumour Epigenetics and Gene Regulation Sun Yat‐Sen Memorial Hospital, Sun Yat‐Sen University; Department of Urology Sun Yat‐sen Memorial Hospital, Sun Yat‐Sen University ShanghaiTech University Clarendon Laboratory University of Oxford Parks Road Oxford OX1 3PU UK Department of Orthopaedics, Center for Musculoskeletal Research, University of Rochester School of Medicine, Rochester, NY 14642, USA Department of Pharmacology and Molecular Sciences, Johns Hopkins School of Medicine, Baltimore, Maryland School of Psychology, South China Normal University, Guangzhou, China Division of Cardiovascular Disease, Department of Medicine, and Department of Biomedical Engineering and Department of Physiology, University of Alabama, Birmingham, Alabama 35294 Department of Urology Sun Yat‐sen Memorial Hospital Sun Yat‐sen (Zhongshan) University Guangzhou China; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Sun Yat‐Sen Memorial Hospital Sun Yat‐Sen University Guangzhou China University of Electronic Science and Technology of China School of Life Science and Technology, , Chengdu, Sichuan 611731 , China Medical Experimental Teaching Department, Nanchang University, Nanchang, China. Department of Microbiology and Immunology, Morse Institute of Molecular Biology and Genetics, and Program in Molecular and Cellular Biology, State University of New York, Brooklyn, New York 11203 National Clinical Research Center for Digestive Disease, Beijing Friendship Hospital, Capital Medical University, Beijing, China; Experimental Center, Beijing Friendship Hospital, Capital Medical University, Beijing, China Department of Biochemistry Rush University Medical Center Chicago Illionois Department of Thoracic Surgery, Wuxi Lung Transplant Center Wuxi People's Hospital Affiliated to Nanjing Medical University Wuxi China Departments of Statistics and Actuarial Science, University of Iowa 2 2 Iowa City, IA, USA Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, China; Collaborative Innovation Center of Systems Biomedicine, Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, China School of Life Science and Technology University of Electronic Science and Technology of China Chengdu China; Centre for Informational Biology University of Electronic Science and Technology of China Chengdu China; Key Laboratory for Neuroinformation of the Ministry of Education University of Electronic Science and Technology of China Chengdu China College of Chinese Medicine, Chongqing Medical University, Chongqing 400050, China. hjian120899@sina.com Department of Urology Sun Yat‐sen Memorial Hospital, Sun Yat‐sen University Guangzhou China Department of Statistics and Actuarial Sciences, University of Iowa, Iowa City, Iowa. From the Departments of Biomedical Engineering (J.M.R., W.M.S., R.E.I.) and Medicine (J.M.R., J.H., W.M.S., R.E.I.), University of Alabama at Birmingham, Birmingham, Ala. Department of Statistics, Medtronic, Minneapolis, Minnesota Division of Neonatology, Department of Pediatrics; Neonatal Developmental Biology Laboratory, Batchelor Children’s Research Institute, and Key Laboratory of Laboratory Medical Diagnostics of Ministry of Education, University of Medical sciences, Chongqing 400016, China. zmchj2001@163.com School of Biology & Basic Medical Science, Soochow University, Suzhou, Jiangsu 215123, P.R. China Department of Urology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen (Zhosngshan) University, Guangzhou, PR China College of Mechanical Engineering, Nanjing Tech University, Nanjing, 211816, China CCNU-uOttawa Joint Research Centre; Key Laboratory of Pesticides & Chemical Biology Ministry of Education, Interna-tional Joint Research Center for Intelligent Biosensing Technology and Health, College of Chemistry; Central China Normal University; Wuhan; China Department of Statistics and Actuarial Science,University of Iowa,221 Schaeffer Hall, Iowa City, Iowa 52242,U.S.A.jian-huang@uiowa.edu Department of Statistics and Actuarial Science, University of Iowa , Iowa City, IA 52242, USA Yunnan General Administration of Forestry Seeds and Seedlings, Kunming, China Department of Obstetrics and Gynecology First Maternal and Infant Hospital of Tongji University Shanghai China Department of Pathology, Guangdong Medical University, Dongguan, Guangdong 523808, P.R. China Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, PR China; The Key Laboratory of Reproductive Physiology and Pathology of Jiangxi Province, Nanchang, Jiangxi, PR China Department of Dermatology The Third Xiangya Hospital of Central South University Changsha China Department of Oncology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China. Liaohe Oil Field Construction Company of China National Petroleum Company, Panjin 124000, China Department of Physics, Clarendon Laboratory, University of Oxford, Parks Road, Oxford OX1 3PU, United Kingdom Department of Medicinal Chemistry and Natural Medicine Chemistry (State‐Province Key Laboratories of Biomedicine‐Pharmaceutics of China) Harbin Medical University Harbin China State Key Laboratory of Luminescent Materials and Devices South China University of Technology Guangzhou 510640 China China–Japan Research Institute of Medical and Pharmaceutical Sciences, Shenyang Pharmaceutical University; Department of Phytochemistry, Shenyang Pharmaceutical University Medtronic, Minneapolis, MN (J.H.). Department of Urology, the Second Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.; Endourological Training Center of Southern China, Guangzhou, China. Department of Oncological Surgery The First Affiliated Hospital of Kunming Medical College Kunming China Authors' Affiliations: 1Cancer Center, Departments of 2Pharmacology and Toxicology, and 3Pathology, Medical College of Wisconsin, Milwaukee, Wisconsin; Authors' Affiliations: 1Cancer Center, Departments of 2Pharmacology and Toxicology, and 3Pathology, Medical College of Wisconsin, Milwaukee, Wisconsin Department of Urology, Minimally Invasive Surgery Center, The First Affiliated Hospital of Guangzhou Medical University, China. huangjianmnwk@163.com. School of Acupuncture and Moxibustion and Tuina, Beijing University of Chinese Medicine, Beijing 100029, China From the Division of Cardiovascular Disease (L.L., J.H., R.E.I.), Department of Medicine; Departments of Biomedical Engineering (R.E.I.) and Physiology (R.E.I.), University of Alabama at Birmingham; Shanghai Ruijin Hospital (Q.J.), Jiaotong University School of Medicine, China; and Peking Union Medical College Hospital (K.-A.C.), Beijing, China. School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, China College of Chemistry and Chemical Engineering, Central South University, Changsha, Hunan, 410083, China Department of Medicine, Veterans Administration Central California Health Care System, 2615 E Clinton Avenue, Fresno, CA 93703, USA; Department of Medicine, University of California, San Francisco, Fresno Medical Education Program, 155 N Fresno Avenue, Fresno, CA 93701, USA Department of Urology, Sun Yat‐Sen Memorial Hospital Sun Yat‐Sen University, Guangzhou, PR, China; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat‐Sen Memorial Hospital Sun Yat‐Sen University, Guangzhou, PR, China Department of Oncology, The Liuzhou Worker’s Hospital, Liuzhou 545000, Guangxi, China Harbin Medical University College of pharmacy Baojian Road 157 Harbin CHINA Department of Urology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangzhou, China Department of Urology, Sun Yat-sen Memorial Hospital; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation; Guangdong Provincial Clinical Research Center for Urological Diseases, Sun Yat-sen (Zhongshan) University, Guangzhou, PR China Cancer Center, The First Affiliated Hospital of Kunming Medical University, Kunming, P.R. China School of Pharmacy, Harbin Medical University, Harbin 150081, China Key Laboratory of Small Functional Organic Molecule, Ministry of Education and Key Laboratory of Green Chemistry, Jiangxi Province, Jiangxi Normal University Jinhua Municipal Central Hospital (Affiliated Jinhua Hospital, School of Medicine, Zhejiang University), Jinhua 321000, Zhejiang, China Department of Physiology Jiangxi Medical College, Nanchang University Nanchang China; Department of Reproductive Physiology Jiangxi Key Laboratory of Reproductive Physiology and Pathology Nanchang China Department of Medicine, University of Alabama at Birmingham, Alabama; and Department of Statistics and Actuarial Science, University of Iowa , Iowa City, Iowa , U.S.A.; School of Statistics and Management, Shanghai University of Finance and Economics , Shanghai , China Ningbo Institute of Marine Medicine, Peking University, Ningbo 315832, Zhejiang, China HTS Center and Global Support Department, AstraZeneca Pharmaceuticals, Wilmington, DE. Department of Oncology, Second Affiliated Hospital, College of Medicine, Zhejiang University Statistics, and Coronary and Structural Heart Clinical Department Mounds View Minnesota From the University of Alabama at Birmingham, Birmingham, Ala. Department of Dermatology; Third Xiangya Hospital, Central South University; Changsha Hunan China Department of Gastroenterology, Nanjing Medical University, Changzhou, Jiangsu, China School of Forensic Medicine, Southern Medical University, Guangzhou 510515, China Department of Haematology The Fourth Affiliated Hospital of Zhejiang University School of Medicine Yiwu China; Department of Haematology The First Affiliated Hospital of Zhejiang University School of Medicine Hangzhou China Department of Neurology, Xijing Hospital, Airforce Military Medical University, Xi'an, Shaanxi 710032, China Key Laboratory of Biomedical Information Engineering of Education Ministry, School of Life Science and Technology, Xi’an Jiaotong University, Xi’an, Shaanxi 710049, People’s Republic of China; College of Chemistry and Chemical Engineering, Xi’an Shiyou University, Xi’an, Shaanxi 710065, People’s Republic of China Center for Clinical Laboratories, The Affiliated Hospital of Guizhou Medical University, Guiyang, 550004, Guizhou, China; School of Clinical Laboratory Science, Guizhou Medical University, University Town, Guian New District, 550025, Guizhou, China Department of Statistics & Actuarial Science, Department of Biostatistics University of Iowa Iowa City IA 52242 U.S.A. School of Life Science and Technology, Authors' Affiliations: 1Lester and Sue Smith Breast Center, Departments of 2Molecular and Cellular Biology, 3Pathology, and 4Molecular and Human Genetics, Baylor College of Medicine; 5Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, TX; and 6Lineberger Comprehensive Cancer Center, Departments of Genetics and Pathology & Laboratory Medicine, and the Carolina Center for Genome Sciences, University of North Carolina, Chapel Hill, North Carolina. Liver Research Center Beijing Friendship Hospital, Capital Medical University, Beijing Key Laboratory of Translational Medicine on Liver Cirrhosis Beijing China; Clinical Research Center for Rare Liver Disease Capital Medical University Beijing China; National Clinical Research Center for Digestive Diseases Beijing China; Experimental Center, Beijing Friendship Hospital Capital Medical University Beijing China From the Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan, China (R. Liu, H.L., M.R., H.W., L.L., R. Lai); Key Laboratory of Molecular Biophysics of the Ministry of Education (Z.Z., P.H., S.W., Z.H., J.D.) and Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, (J.L., P.L.), Huazhong University of Science and Technology, Wuhan, Hubei, China; Life... School of Chemistry and Chemical Engineering, Xi’an Shiyou University, Xi’an 710065, P. R. China Institute of Biochemistry and Cell Biology, Shanghai Institute for Biological Sciences,the Chinese Academy of Sciences, Shanghai 200031, China. qianlab@sumn.shcnc.ac.cn Key Laboratory of Trace Element Nutrition of National Health Commission of the People’s Republic of China, National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, Beijing 100050, China Department of Stomatology, Changzheng Hospital, Second Military Medical University, Shanghai 200003, P.R. China Department of Biostatistics, University of Iowa, Iowa City, Ia., U.S.A. Beijing Dongfang Hospital, Beijing University of Chinese Medicine, Beijing 100029, China College of Agricultural and Food Engineering, Baise University, Baise 533000, China. Department of Natural Products Chemistry; School of Traditional Chinese Materia Medica; Key Laboratory of Structure-Based Drug Design & Discovery; Ministry of Education; Shenyang Pharmaceutical University Department of Acupunture, Beijing Dong Fang Hospital, Beijing 100078, China. Department of Hepatobiliary Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China. Department of General surgery Jiujiang First People's Hospital Jiujiang China Protein Science Laboratory of the Ministry of Education, Department of Biological Sciences and Biotechnologies, Tsinghua University, Beijing 100084, China (J.H., F.C., M.S., S.Y., J.P., Y.L.); Dipartimento di Scienze Ambientali, Università di Siena, via Mattioli 4, 53100 Siena, Italy (C.D.C., A.A., M.C.); and Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences State Key Laboratory of Natural and Biomimetic Drugs, Institute of Ocean Research, Peking University, Beijing 100191, P. R. China Department of Dermatology The Third Xiangya Hospital Central South University Changsha China Department of Dermatology, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, P.R. China Department of Blood Chemotherapy, Wenzhou Central Hospital, Zhejiang P.R. China Department of Hepatic Surgery (III), Third Affiliated Hospital of Naval Medical University, Shanghai, China From the Cardiac Rhythm Management Laboratory, Division of Cardiovascular Disease, Department of Medicine (J.H., R.E.I.), Department of Physiology (R.E.I.), and Department of Biomedical Engineering (W.M.S., R.E.I.), University of Alabama at Birmingham, and Tachyarrhythmia Research, Medtronic Inc, Minneapolis, Minn (X.Z.). Department of Urology, the Second Affiliated Hospital, Sun Yat-sen University, Guangzhou, China. Center for Informational Biology, University of Electronic Science and Technology of China , Chengdu, China Guangxi Zhuang Autonomous Region Center for Disease Prevention and Control, Jin Zhou Road, Nanning, Guangxi 530028, PR China Hunan Key Laboratory of Micro & Nano Materials Interface Science; College of Chemistry and Chemical Engineering, Central South University, Changsha, Hunan 410083, China Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, Norfolk Place, London SW7 2AZ, United Kingdom; UK Dementia Research Institute at Imperial College London, Hammersmith Hospital, London W12 0NN, United Kingdom; Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research, 138632 Singapore Department of Urology, Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China. yehjn@yahoo.com.cn Department of Statistics and Actuarial Science University of Iowa Iowa City IA USA 1Department of Urology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China. Experimental Center, Beijing Friendship Hospital, Capital Medical University, Beijing, China; National Clinical Research Center for Digestive Disease, Beijing Friendship Hospital, Capital Medical University, Beijing, China Department of Statistics & Actuarial Science University of Iowa Iowa City Iowa United States of America State Key Laboratory of Advanced Design and Manufacturing for Vehicle Body, College of Mechanical and Vehicle Engineering, Hunan University, Changsha 410082, China Experimental Center, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, P.R. China Wuxi Lung Transplant Center Department of Thoracic Surgery Wuxi People's Hospital affiliated to Nanjing Medical University Wuxi China Department of Urology and Lin Bai-xin Research Center (QP, XF), Second Affiliated Hospital, Sun Yat-sen University, Guangzhou, People's Republic of China 1Department of Urology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.; 2Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Medical Research Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.; 3State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, China. Key Laboratory for Green Chemistry of Jiangxi Province, Key Laboratory of Functional Small Molecules for Ministry of Education, Jiangxi Normal University, 99 Ziyang Avenue, Nanchang 330022, China Department of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory of Tumor Microenvironment and Inflammation, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China Key Laboratory of Structure-Based Drug Design & Discovery, Department of Natural Products Chemistry, School of Traditional Chinese Materia Medica, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China Department of Lung Transplant Center, Wuxi People's Hospital Affiliated to Nanjing Medical University, Wuxi, Jiangsu 214023, China Department of Statistics & Actuarial Science University of Iowa Iowa City, Iowa U.S.A. Department of Intensive Care Unit, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, P.R. China Division of Cardiovascular Disease Department of Medicine University of Alabama at Birmingham Birmingham AL USA Department of Thoracic Surgery, Jiangxi Cancer Hospital, Nanchang, Jiangxi, China Experimental Center, Beijing Friendship Hospital Capital Medical University Beijing China; Clinical Research Center for Rare Liver Diseases Capital Medical University Beijing China; Liver Research Center National Clinical Research Center for Digestive Diseases Beijing China; Beijing Key Laboratory of Translational Medicine on Liver Cirrhosis, Liver Research Center, Beijing Friendship Hospital Capital Medical University Beijing China Department of Statistics and Actuarial Science, University of Iowa, Iowa City, IA 52242, USA. Laboratory of RNA Biology, Institute of Biophysics, Chinese Academy of Science, 15 Datun Road, Beijing 100020, P.R. China Department of Medicinal Chemistry and Natural Medicine Chemistry, College of Pharmacy, Harbin Medical University, Harbin 150000, China Department of Statistics, Medtronic, Minneapolis, Minnesota. Department of Gynecology and Obstetrics, Second Xiangya Hospital, Central South University, Changsha 410011. huangjian2566@csu.edu.cn. From the Cardiac Rhythm Management Laboratory, Division of Cardiovascular Diseases, Department of Medicine, Department of Physiology, and Department of Biomedical Engineering, University of Alabama at Birmingham (J.H., D.L.R., W.M.S., R.E.I.), Birmingham, Ala, and Guidant Corporation (B.H.K.), Cardiac Rhythm Management Group, St Paul, Minn. School of Chemistry Environmental Engineering, Wuhan Institute of Technology, Wuhan 430073, China Division of Nephrology and Rheumatology Shanghai Tenth People's Hospital Shanghai China; Center for Nephrology and Metabolomics Tongji University School of Medicine Shanghai China Department of Cardiology, Fuwai Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing 100037, P.R. China State Key Laboratory for Mechanical Behavior of Materials, School of Materials Science and Engineering, Xi’an Jiaotong University, Xi’an, Shaanxi 710049, P. R. China; Key Laboratory of Biomedical Information Engineering of Education Ministry, School of Life Science and Technology, Xi’an Jiaotong University, Xi’an, Shaanxi 710049, P. R. China School of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou 510006, Guangdong, China University of Science and Technology of China; Anhui Institute of Optics and Fine Mechanics; State Key Laboratory of Pulsed Power Laser Technology Cancer Institute, Key Laboratory of Cancer Prevention & Intervention, National Ministry of Education, Provincial Key Laboratory of Molecular Biology in Medical Sciences, The Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang University, Hangzhou, China; Department of Surgical Oncology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang University, Hangzhou, China Department of Vascular surgery, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, China Chinese National Human Genome Center at Shanghai, 351 Guo Shou-Jing Road, Shanghai 201203, China; Shanghai Institute of Hematology, Rui Jin Hospital, 197 Rui Jin Road II, Shanghai 200025, China; National Laboratory for Oncogenes and Related Genes, Shanghai Cancer Institute, 25 Lane 2200, Xietu Road, Shanghai 200032, China; Shanghai Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 200031, China;... Department of Urology, Sun Yat‐Sen Memorial Hospital Sun Yat‐Sen University Guangzhou People's Republic of China; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Sun Yat‐Sen Memorial Hospital, Sun Yat‐Sen University Guangzhou People's Republic of China Department of Sports Medicine, Limin Hospital, Weihai City Central Hospital, Weihai, China Department of Endocrine and Metabolic Diseases (Y.D., H.W., Y.L., S.L., Q.Z., J.H., R.Z., J.Y., R.Z., D.Z., G.N., Y.Y.), Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, 197 Ruijin Rd II, Shanghai 200025, China College of Physics Science and Technology, Kunming University, Kunming, Yunnan, 650214, China Department of Materials Science & Engineering CAS Key Lab of Materials for Energy Conversion University of Science and Technology of China Hefei Anhui 230026 China Department of Biochemistry and Molecular Cell Biology Shanghai Key Laboratory of Tumor Microenvironment and Inflammation Shanghai Jiao Tong University School of Medicine China Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, China; Pharmacology and Toxicology Division, Shanghai Institute of Food and Drug Control, Shanghai, China Primary Care Service Veterans Administration Central California Health Care System Fresno California; Department of Medicine University of California San Francisco, Fresno Medical Education Program Fresno California College of Science, National University of Defense Technology, Changsha, 410073, P. R. China Pharmaceutical Sciences Research Center Department of Pharmacy Children's Hospital of Nanjing Medical University Nanjing China Department of Pathology, Guangdong Medical University, Zhanjiang, Guangdong 524023, P.R. China Department of Orthopaedics, the Second Affiliated Hospital of Inner Mongolia Medical University, China Shanghai Frontiers Science Center of TCM Chemical Biology, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China; Pharmacology and Toxicology Division, Shanghai Institute of Food and Drug Control, Shanghai 201203, China Department of Orthopedic Surgery Spine Center Changzheng Hospital Naval Medical University (Second Military Medical University) Shanghai 200003 P. R. China Department of Emergency Medicine, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, P.R. China School of Mechanical and Precision Instrument Engineering, Xi’an University of Technology, Xi’an 710048, China; School of Computer Science, Xijing University, Xi’an 710123, China School of Environmental and Safety Engineering, Changzhou University, Changzhou 213164, China. Pharmacology and Toxicology Division, Shanghai Institute of Food and Drug Control, Shanghai 201203, China Guangzhou Institute of Traumatic Surgery, Guangzhou Red Cross Hospital of Jinan University, Guangzhou 510220, China. Department of Traumatic Orthopedics, The Central Hospital of Xiaogan, Hubei 432100, China. Department of Gastroenterology Yuyao People's Hospital, Medical School of Ningbo University Ningbo China School of Biology & Basic Medical Sciences; Soochow University; Suzhou; P. R. China Department of Oncology Second Affiliated Hospital, Zhejiang University School of Medicine Hangzhou China; Key Laboratory of Tumor Microenvironment and Immune Therapy of Zhejiang Province Hangzhou China; Cancer Center Zhejiang University Hangzhou China Acupuncture Department, Dongfang Hospital, Second Affiliated Hospital of Beijing University of Chinese Medicine , Gusu School of Nanjing Medical University, , , , China Program in Molecular and Cellular Biology, Department of Microbiology and Immunology, SUNY Downstate Medical Center, Brooklyn, New York 11203, USA. Division of Pharmaceutical Sciences and Department of Chemistry, University of Wisconsin, Madison, Rennebohm Hall, 777 Highland Avenue, Madison, Wisconsin 53705 Department of Breast Surgery, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China Department of Statistics and Actuarial Science University of Iowa Iowa City Iowa Department of Craniofacial Biology and Department of Cell and Developmental Biology, University of Colorado Denver, Aurora, Colorado. Center for Nephrology and Metabolomics, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, 200072 Shanghai, People’s Republic of China;; Division of Nephrology and Rheumatology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, 200072 Shanghai, People’s Republic of China; *Laboratory of Molecular Immunoregulation, Cancer and Inflammation Program and Electrical and Computer Engineering, National University of Singapore, Singapore 117576 The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China. Department of Cell Biology and Genetics, Guilin Medical University, Guilin, Guangxi 541005, P.R. China *Department of Immunology, Department of Trauma, Third Affiliated Hospital, Third Military Medical University, Chongqing, P. R. China 400042. School of Life Science and Technology University of Electronic Science and Technology of China Chengdu, 610054 China; Center for Informational Biology University of Electronic Science and Technology of China Chengdu, 610054 China Department of Orthopaedics, Liaocheng People's Hospital and Liaocheng Clinical School of Taishan Medical University, Liaocheng, Shandong, People's Republic of China Division of Pharmaceutical Sciences and Department of Chemistry, University of Wisconsin at Madison, Madison, Wisconsin 53705, United States Shenzhen YiShengTang Biology Medicine Ltd, Shenzhen 518026, China. Medtronic, Minneapolis, Minneapolis. Department of Urology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, 107 Yanjiangxi Road, Yuexiu District, Guangzhou 510120, Guangdong, China Department of Nutrition and Food Hygiene Guangdong Provincial Key Laboratory of Tropical Disease Research School of Public Health and Tropical Medicine Southern Medical University Guangzhou Guangdong P. R. China Key Laboratory of Tumor Microenvironment and Immune Therapy of Zhejiang Province Hangzhou, Zhejiang, China. Cancer Center, Zhejiang University Hangzhou, Zhejiang, China. Department of Molecular Biology Princeton University Princeton 08544 USA Key Laboratory of Systems Biomedicine (Ministry of Education) and Collaborative Innovation Center of Systems Biomedicine, Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, People’s Republic of China Central Laboratory, Affiliated Hospital of Jining Medical University, Jining, Shandong, China Department of Physiology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9040; and Division of Molecular Biology and Biochemistry, Room B412, University of Missouri, 5007 Rockhill Road, Kansas City, MO 64110-2499 Departments of Medicine,1 Department of Statistics and Actuarial Science, and Department of Biostatistics, University of Iowa, Iowa City, IA 52242, USA 2Department of Pathology and Laboratory Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania. Department of Oncology, 2nd Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310009 PR China. hjys@zju.edu.cn Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510123, China University of Texas Southwestern Medical Center at Dallas, Department of Physiology, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA National Institute for Nutrition and Health Chinese Centre for Disease Control and Prevention Beijing China Key Laboratory of Structure‐Based Drug Design & Discovery of Ministry of Education School of Traditional Chinese Materia Medica Shenyang Pharmaceutical University Shenyang 110016 China Third Department of Hepatic Surgery Eastern Hepatobiliary Surgery Hospital Second Military Medical University Shanghai China Department of Clinical Laboratory, 2Department of Blood Transfusion, Affiliated Hospital of Zunyi Medical College, Zunyi 563003, China. E-mail: 81537648@qq.com. 1 Statistical Laboratory, Department of Statistics, University College Cork, Ireland, 2MRC Biostatistics Unit, Institute of Public Health, Cambridge CB2 2SR, UK, 3Department of Oncology, University Hospital, SE-221 85 Lund and 4Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden State Key Laboratory of Coordination Chemistry; School of Chemistry and Chemical Engineering; Collaborative Innovation Center of Advanced Microstructures; Nanjing University; Nanjing 210093 School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, P.R. China, College of Pharmacy, Nihon University, Chiba 274-8555, Japan, and College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao 266042, P.R. China Liver Research Center, Experimental Center, Beijing Friendship Hospital, Capital Medical University, Beijing Key Laboratory of Translational Medicine in Liver Cirrhosis, Beijing, 100050, P.R. China Department of General Practice, Jiangping Health Station of Dongxing City, Dongxing, China College of Life Sciences, Wuhan University, Wuhan 430072, China Department of Internal Medicine,Luoding People's Hospital, Luoding 527200, China. Beijing Agro‐product Safety and Quality Center Beijing China CCNU-uOttawa Joint Research Centre; Key Laboratory of Pesticides & Chemical Biology Ministry of Education; International Joint Research Center for Intelligent Biosensing Technology and Health; College of Chemistry; Central China Normal University Coriell Institute for Medical Research, Camden, NJ, USA; Center for Metabolic Disease Research, Temple University Lewis Katz School of Medicine, Philadelphia, PA, USA; Cooper Medical School of Rowan University, Camden, NJ, USA Department of Tuberculosis, The First Affliated Hospital of Xinxiang Medical University, Weihui, China 6Physical Examination Center of East Ward, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou City, Guangdong Province, China. 3Statistics and Actuarial Science, University of Iowa, Iowa City, Iowa; Central Laboratory, Affiliated Hospital of Jining Medical University, Jining, Shandong 272029, P.R. China Bone-Muscle Research Center, College of Nursing & Health Innovation, University of Texas at Arlington-UTA, Arlington, Texas Department of Statistics and Actuarial Science University of Iowa Iowa City Iowa United States of America Key Laboratory for Neuroinformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 610054, China School of Materials Science and Chemical Engineering; Ningbo University; Ningbo 315211; People's Republic of China Department of Pathology National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Shenzhen P. R. China College of Life Sciences Wuhan University No. 299 Bayi Road Wuhan 430072 P.R. China Department of Urology Sun Yat‐sen Memorial Hospital, Sun Yat‐sen University; Key Laboratory of Malignant Tumour Gene Regulation and Target Therapy of Guangdong Higher Education Institutes Sun Yat‐sen University Guangzhou China Xiangya Boai Rehabilitation Hospital , No. 61 Wanjiali North Road, Changsha, 410000, Hunan Province , China Pharmacology and Toxicology Division, Shanghai Institute of Food and Drug Control, 1111 Halei Road, Shanghai, 201203, China Department of Urology; Minimally Invasive Surgery Center; The First Affiliated Hospital of Guangzhou Medical University; Guangdong Key Laboratory of Urology; Guangzhou China School of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou Guangdong 510006, China Authors' Affiliations: 1Department of Pharmacology and Therapeutics; McGill University; 2Sackler program for Psychobiology and Epigenetics at McGill University; 3McGill Centre for Bioinformatics, Montreal, Canada; and 4Shanghai-MOST Key Laboratory for Disease and Health Genomics, Chinese National Human Genome Center at Shanghai, Shanghai, China Department of Life Science and Biochemistry, Shenyang Pharmaceutical University, Shenyang, China Department of Breast Surgery; Key Laboratory of Tumor Microenvironment and Immune Therapy of Zhejiang Province; Cancer Institute, The Second Affiliated Hospital, Zhejiang University School of Medicine; Cancer Center, Zhejiang University, Hangzhou, Zhejiang, China State Key Laboratory of Membrane Biology, Beijing Advanced Innovation Center for Structural Biology, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China Department of Statistics and Actuarial Science University of Iowa Iowa IA USA School of Information Engineering, Qujing Normal University, Qujing 655000, China Hepatic Surgery Department III, Eastern Hepatobiliary Surgery Hospital, The Second Military Medical University, National Innovation Alliance for Hepatitis & Liver Cancer, Shanghai, P. R. China Department of Urology Sun Yat‐sen Memorial Hospital Sun Yat‐sen University Guangzhou Guangdong 510120 P. R. China; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Sun Yat‐sen Memorial Hospital Sun Yat‐sen University Guangzhou Guangdong 510120 P. R. China; Guangdong Provincial Clinical Research Center for Urological Diseases Guangzhou Guangdong 510120 P. R. China Department of Nephrology Central Hospital of Jinhua Jinhua China; Hemodialysis Quality Control Center of Jinhua Jinhua China Medtronic Minneapolis MN School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China People's Hospital of Maqin County, Guoluo 814099, Qinghai, China. Corresponding author: Bao Jimin, Email: nose_bao@sohu.com. Center for Nephrology and Metabolomics and Division of Nephrology and Rheumatology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai 210072, People’s Republic of China; Department of Urology Guangdong Key Laboratory of Urology Minimally Invasive Surgery Center The First Affiliated Hospital of Guangzhou Medical University Guangzhou China From the Departments of Biomedical Engineering (J.M.R., R.E.I.) and Medicine (J.H., S.B.M., R.E.I.), University of Alabama at Birmingham, Birmingham, Ala. *Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute-Frederick, Frederick, MD 21702; College of Animal & Veterinary Sciences Southwest Minzu University Chengdu China; Key Laboratory of Ministry of Education and Sichuan Province for Qinghai‐Tibetan Plateau Animal Genetic Resource Reservation and Utilization Chengdu China Center for Informational Biology, University of Electronic Science and Technology of China, Chengdu, Sichuan Province, China School of Materials Science and Engineering Shanghai University Nanchen Road Shanghai 200444 China Department of Dermatology, Third Xiangya Hospital, Central South University, Changsha 410013, China. Department of Joint Surgery, Meizhou Hospital Affiliated to Sun Yat-sen University, Meizhou 514031, Guangdong, China. Department of Anesthesia, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, PR China Cancer Research Institution, Central South University, Changsha 410078, China. Institute of Soil Fertilizer, Agricultural Water Saving, Xinjiang Academy of Agricultural Sciences, Urumqi 830091, China; Key Laboratory of Saline-Alkali Soil Improvement and Utilization (Saline-Alkali Land in Arid and Semi-Arid Regions), Ministry of Agriculture and Rural Affairs, Urumqi 830091, China Department of Medicinal Chemistry, Center for Pharmaceutical Research and Development School of Pharmacy Southwest Medical University Luzhou Sichuan 646000 PRC Department of Nephrology, 455th hospital of PLA, Shanghai 200052, China Shandong Provincial Key Laboratory of Cardiac Disease Diagnosis and Treatment, Affiliated Hospital of Jining Medical University, Jining Medical University, Jining, China. Drug Development Department, Shenzhen Honghui Bio-Pharmaceutical Co. Ltd., Shenzhen, China Department of Statistics and Actuarial Science University of Iowa Iowa Iowa USA Department of Biochemistry and Molecular Cell Biology State Key Laboratory of Oncogenes and Related Genes Shanghai Key Laboratory of Tumor Microenvironment and Inflammation Shanghai Jiao Tong University School of Medicine Shanghai China Department of Orthopaedics, Yangjiang People’s Hospital, Yangjiang, China; Key Laboratory of Arrhythmias of the Ministry of Education of East Hospital (L.G., S.W., F.Z., K.X., J.H., T.Z., D.S., F.L., D.L., Y.C., Y.L., D.X., Y.-H.C.), Tongji University, Shanghai, China.; Institute of Medical Genetics (L.G., S.W., F.Z., K.X., J.H., T.Z., D.S., F.L., L.L., D.L., Y.C., Y.L., D.X., Y.-H.C.), Tongji University, Shanghai, China. Department of Reproductive Medicine Center, Hangzhou Women's Hospital (Hangzhou Maternity and Child Health Care Hospital), Hangzhou, Zhejiang, China Department of Aquatic Animal Medicine, College of Fisheries, Huazhong Agricultural University, Wuhan 430070, People’s Republic of China. Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Medical Research Center, Sun Yat‐Sen Memorial Hospital Sun Yat‐Sen (Zhongshan) University Guangzhou China; Department of Urology, Sun Yat‐sen Memorial Hospital Sun Yat‐sen (Zhongshan) University Guangzhou China; Guangdong Provincial Clinical Research Center for Urological Diseases Guangzhou China Department of Medicinal Chemistry and Natural Medicine Chemistry, State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Harbin Medical University, Harbin 150081, China; Shenzhen Honghui Biopharmaceutical Co., Ltd. Shenzhen 518000, China Hunan Province Key Laboratory of Plant Functional Genomics and Developmental Regulation, State Key Laboratory of Chemo/Biosensing and Chemometrics National Center of Technology Innovation for Saline‐Alkali Tolerant Rice, College of Biology, Hunan University Changsha 410082 Hunan China State Key Laboratory of Coordination Chemistry, Cordination Chemistry Institute, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, P. R. China Department of Hematology, the First Affiliated Hospital of the Medical College of Zhejiang University, Hangzhou 310003, China. Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Centre for Systems Biomedicine, Shanghai Jiao Tong University , Shanghai , China Department of Urology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, People’s Republic of China; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, People’s Republic of China Medtronic, Minneapolis, Minnesota. From the Department of Internal Medicine, The Holden Comprehensive Cancer Center; and Department of Statistics, University of Iowa, Iowa City. Key Laboratory of Arrhythmias of the Ministry of Education of China, East Hospital, Tongji University School of Medicine, Shanghai, China; Department of Cardiology, East Hospital, Tongji University School of Medicine, Shanghai, China Department of Biostatistics, University of Iowa, Iowa City, IA, USA; Department of Statistics and Actuarial Science, University of Iowa, Iowa City, IA, USA Department of Urology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University , Guangzhou 510120, China; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangdong-Hong Kong Joint Laboratory for RNA Medicine, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University , Guangzhou 510120, China AstraZeneca R&D Boston, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States Research Institute of Materials Science, South China University of Technology, Guangzhou 510640, People’s Republic of China XtalPi AI Research Center; Beijing 100083; P. R. China Department of Anesthesiology, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, 710061, China Guangdong Key Laboratory of Diagnosis and Treatment for Emerging Infectious Diseases, Shenzhen Key Laboratory of Infection and Immunity, Shenzhen Third People’s Hospital, Shenzhen, Guangdong, China; Shenzhen People's Hospital, Second Clinical Medical College of Jinan University, Shenzhen, Guangdong, China; Key Laboratory of Systems Biomedicine, Ministry of Education and Collaborative Innovation Center of Systems Biomedicine, Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, China Coriell Institute for Medical Research Camden NJ USA Department of Pathological Diagnosis and Research Center, The Affiliated Hospital of Guangdong Medical University, Zhanjiang 524001, China. Experimental Center, Beijing Friendship Hospital, Capital Medical University; Beijing China; Beijing Key Laboratory of Translational Medicine on Liver Cirrhosis; Liver Research Center, Beijing Friendship Hospital, Capital Medical University; Beijing China; Clinical Research Center for Rare Liver Diseases, Capital Medical University; Beijing China; Liver Research Center, National Clinical Research Center for Digestive Diseases; Beijing China Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100080, China Biostatistics,; Statistics, and Center of Bioinformatics (COBI); School of Life Science and Technology; University of Electronic Science and Technology of China (UESTC); Chengdu 610054; China Viral Oncology Program, Sidney Kimmel Cancer Center; Department of Pharmacology and Molecular Sciences, Johns Hopkins School of Medicine, Baltimore, Maryland Department of Breast Surgery Second Affiliated Hospital, Zhejiang University Hangzhou China; Key Laboratory of Tumor Microenvironment and Immune Therapy of Zhejiang Province Second Affiliated Hospital, Zhejiang University Hangzhou China; Cancer Center Zhejiang University Hangzhou China Department of Respiratory Medicine The Fourth Hospital of Changsha Changsha Hunan China Cancer Institute (Key Laboratory of Cancer Prevention & Intervention, National Ministry of Education, Provincial Key Laboratory of Molecular Biology in Medical Sciences), The Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou 310009 China; Department of Oncology, Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou 310009 China State Key Laboratory of High Performance Ceramics and Superfine Microstructure; Shanghai Institute of Ceramics; Chinese Academy of Sciences; Shanghai 200050; P. R. China The Department of Urology, AnHui NO.2 Provincial People Hospital Hefei China Department of Wood Science and Engineering Oregon State University Corvallis OR 97331 USA From the Houston Methodist DeBakey Heart and Vascular Institute, TX (N.S.K., M.J.R.); Tenet Healthcare Corporation, Delray Beach, FL (B.J.M.); Johns Hopkins University, Baltimore, MD (J.C.); Hofstra North Shore University Hospital, New Hyde Park, NY (S.K., A.H.); Hartford Hospital, CT (R.M., R. H.); Piedmont Heart Institute, Atlanta, GA (V.R., J.K.); Medtronic, Minneapolis, MN (J.H.); and Beth Israel Deaconess Medical Center, Boston, MA (J.J.P.). Department of Physiology, University of Texas Southwestern Medical Center, Dallas, TX 75390 3 Department of Statistics and Actuarial Science Department of Statistics and Actuarial Science and Department of Biostatistics University of Iowa Iowa City, Iowa Experimental Centre Beijing Friendship Hospital Capital Medical University Beijing China; Clinical Research Centre for Rare Liver Diseases Capital Medical University Beijing China; National Clinical Research Centre for Digestive Diseases Beijing China; Liver Research Centre Beijing Friendship Hospital, Capital Medical University; Beijing Key Laboratory of Translational Medicine on Liver Cirrhosis Beijing China Laboratory of Hepatobiliary and Pancreatic Surgery, Affiliated Hospital of Guilin Medical University, Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, China; Key Laboratory of Systems Biomedicine (Ministry of Education), Collaborative Innovation Center of Systems Biomedicine, Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, China; Shenzhen Key Laboratory of Infection and Immunity, Shenzhen Third People's Hospital, Guangdong Medical College, Shenzhen, China; Shanghai-MOST Key Laboratory for Disease and Health Genomics, Chinese National Human Genome Center, Shanghai, China Department of Urology, Sun Yat-Sen Memorial Hospital Sun Yat-Sen University, Guangzhou, PR China; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital Sun Yat-Sen University, Guangzhou, PR China Department of Urology, Sun Yat-Sen Memorial Hospital Sun Yat-Sen University, Guangzhou, China. Department of Gynecology, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, China. Department of Pediatrics, University of Miami Miller School of Medicine, Miami, FL, USA; Batchelor Children’s Research Institute, University of Miami Miller School of Medicine, Miami, FL, USA Department of Thoracic Surgery Maoming People's Hospital Maoming China Key Laboratory of Biomedical Information Engineering of Education Ministry, School of Life Science and Technology, Xi’an Jiaotong University, Xi’an, Shaanxi 710049, P. R. China Department of Urology, The Sun Yat‐sen Memorial Hospital Sun Yat‐sen University Guangzhou China Experimental Center; Beijing Friendship Hospital; Capital Medical University; Beijing China; National Clinical Research Center for Digestive Disease; Beijing Friendship Hospital; Capital Medical University; Beijing China Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Bayi Road, Wuhan 430072, China School of Traditional Chinese Materia Medica Shenyang Pharmaceutical University Shenyang 110016 China State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering, Key Laboratory of Green Pesticide and Agriculture Bioengineering, Ministry of Education, Center for Research and Development of Fine Chemicals, Guizhou University Department of Clinical Laboratory, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou Province, China Information Center, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, China.; Sino-Finland Joint AI Laboratory for Child Health of Zhejiang Province, Hangzhou, China.; National Clinical Research Center for Child Health, Hangzhou, China. From the Nora Eccles Harrison Cardiovascular Research and Training Institute (N.P., R.R., D.J.D.), Division of Cardiothoracic Surgery, Department of Surgery (D.J.D.), and Division of Cardiovascular Medicine, Department of Medicine (L.L., R.R., D.J.D.), University of Utah, Salt Lake City; and Division of Cardiovascular Disease, School of Medicine, University of Alabama at Birmingham (J.H., R.E.I.). Department of Urology Sun Yat‐sen Memorial Hospital Guangzhou China; Key Laboratory of Malignant Tumor Gene Regulation and Target Therapy of Guangdong Higher Education Institutes Guangzhou China Department of Statistics and Actuarial Science; University of Iowa; Iowa City Iowa United States of America ERA Co., Ltd, Taizhou 318000, China Department of Forensic Genetics West China School of Basic Science and Forensic Medicine Sichuan University (West China University of Medical Sciences) Chengdu Sichuan P. R. China Department of Vascular surgery, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, Jiangsu, China Medtronic, Mounds View, Minnesota, USA. 6Department of Medical Oncology, Zhejiang Cancer Hospital, Shanghai, P.R. China. Molecular Virology Laboratories, Department of Pharmacology and Molecular Sciences School of Life Science and Technology University of Electronic Science and Technology of China (UESTC) Chengdu China BGI-Shenzhen, Shenzhen, China Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; Shanghai Institute of Food and Drug Control, Shanghai 201203, China College of Life Sciences; Wuhan University; Wuhan; China Division of Cardiovascular Disease, Department of Medicine, Dongzhimen Hospital, Beijing University of Chinese Medicine Beijing 100700, China. 4 Department of Statistics and Actuarial Science, University of Iowa, Iowa, IA, USA, State Key Laboratory of Translational Cardiovascular Medicine, Fuwai Hospital & Cardiovascular Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, 167 Bei-Li-Shi Road, Xi-Cheng, Beijing 100037, China Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai 200240, China Department of Urology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China. College of Science National University of Defense Technology Changsha 410073 China Institute for Nutrition and Health, China Center for Disease Control and Prevention, Beijing, China Department of Chemistry, Fudan University, Shanghai 200433, China School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China Department of Anatomy and Cell Biology and of University of Kansas Medical Center , Kansas City Center for Informational Biology, University of Electronic Science and Technology of China Sun Yat-Sen University, Guangzhou, People’s Republic of China Division of Engineering and Applied Sciences, Department of Physics, and Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, Materials Department, University of California, Santa Barbara, California 93106 Department of Physics, Clarendon Laboratory, Parks Road, Oxford OX1 3PU, United Kingdom School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine, Beijing, China Department of Orthopedic Surgery Rush University Medical Center Chicago Illinois Department of Urology, Minimally Invasive Surgery Center, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China; Guangzhou Institute of Urology, Guangzhou, Guangdong, China; Guangdong Key Laboratory of Urology, Guangzhou, Guangdong, China Department of Pathology and Laboratory Medicine, Temple University Lewis Katz School of Medicine, Philadelphia, PA; Department of Vascular/Interventional Radiology, Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Suzhou, P.R. China. Center for Informational Biology, University of Electronic Science and Technology of China, Chengdu 611731, China Department of Pathophysiology and High Altitude Medicine, Third Military Medical University of Chinese People's Liberation Army, Chongqing 400038, China. Department of Forensic genetics Brains hospital of Hunan province Changsha 410007 China Department of Surgical Oncology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310009, P.R.China Florida International University. Department of Urology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, China Department of Surgical Oncology, Second Affiliated Hospital and Cancer Institute (Key Laboratory of Cancer Prevention & Intervention, National Ministry of Education, Provincial Key Laboratory of Molecular Biology in Medical Sciences), Zhejiang University School of Medicine, Hangzhou, China; Gastroenterology Institute, Zhejiang University School of Medicine, Hangzhou, China Department of Medical Oncology, Zhejiang Cancer Hospital, Hangzhou, Zhejiang 310022, P.R. China Department of Chemistry, University of Minnesota, Minneapolis, Minnesota 55455 Institute of Pathology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University, Chongqing 400038, China Department of Surgical Oncology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China; Gastroenterology Institute, Zhejiang University School of Medicine, Hangzhou, China Department of Materials Science & Engineering; CAS Key Lab of Materials for Energy Conversion; University of Science and Technology of China; Hefei, China Department of Gynecology, Nanjing Medical University, Affiliated Hangzhou Hospital (Hangzhou First People's Hospital, Hangzhou Obstetrics & Gynecology Hospital), Hangzhou, Zhejiang Province, China Bone-Muscle Research Center, College of Nursing & Health Innovation, the University of Texas at Arlington, Arlington, TX, USA Department of Cancer Center, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, P.R. China Department of Pediatrics/Division of Neonatology, University of Miami Miller School of Medicine, Miami, FL, USA; Batchelor Children's Research Institute, University of Miami Miller School of Medicine, Miami, FL, USA State Key Laboratory of High‐Performance Precision Manufacturing Dalian University of Technology Dalian 116024 China; Key Laboratory for Micro/Nano Technology and System of Liaoning Province Dalian University of Technology Dalian 116024 China Experimental Center, Beijing Friendship Hospital, Capital Medical University, Beijing, China. Department of Urology Minimally Invasive Surgery Center, The First Affiliated Hospital of Guangzhou Medical University Guangzhou China; Guangdong Key Laboratory of Urology Guangzhou Urology Research Institute Guangzhou China Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing Key Laboratory of Translational Medicine in Liver Cirrhosis & National Clinical Research Center of Digestive Diseases, Beijing 100050, China Center for Informational Biology, University of Electronic Science and Technology of China, No. 2006, Xiyuan Ave, West Hi-Tech Zone, Chengdu 611731, P. R. China Department of Dermatology, Third Xiangya Hospital Central South University Changsha Hunan 410013 China Division of Neonatology, Department of Pediatrics, and College of Life Sciences; Wuhan University; Wuhan 430072; China State Key Laboratory for Mechanical Behavior of Materials, School of Materials Science and Engineering, Xi’an Jiaotong University, Xi’an, Shaanxi 710049, People’s Republic of China; Key Laboratory of Biomedical Information Engineering of Education Ministry, School of Life Science and Technology, Xi’an Jiaotong University, Xi’an, Shaanxi 710049, People’s Republic of China Department of Statistics and Actuarial Science , University of Iowa , Iowa City , USA Department of Experimental Centre, Beijing Friendship Hospital, Capital Medical University, Beijing, P.R. China Primary Care Service VA Central California Health Care System Fresno CA; Department of Medicine University of California San Francisco‐Fresno Medical Education Program Fresno CA Department of Urology Sun Yat‐sen Memorial Hospital Sun Yat‐sen University Guangzhou China Department of Biotechnology, College of Life Sciences, Fujian Normal University, Fuzhou 350108, China Department of Urology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, People's Republic of China; Endourological Training Center of Southern China, Guangzhou, Guangdong, People's Republic of China Department of Urology, the Second Affiliated Hospital of Sun Yat-sen University, Guangzhou 510120, China. yehjn@yahoo.com.cn School of Chemical Engineering and Light Industry Guangdong University of Technology, Guangzhou 510006 Guangdong P.R. China Key Laboratory of Functional Small Organic Molecule; Ministry of Education; Jiangxi Province's Key Laboratory of Green Chemistry; Jiangxi Normal University; Nanchang From the Cardiac Rhythm Management Laboratory, Department of Medicine, Division of Cardiovascular Diseases, University of Alabama at Birmingham, and Cardiac Pacemakers, Inc, a Division of Guidant Corp, St Paul, Minn (B.H.K.). Department of Urology Sun Yat‐sen Memorial Hospital Sun Yat‐sen University Guangzhou P. R. China; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Sun Yat‐sen Memorial Hospital Sun Yat‐sen University Guangzhou P. R. China Department of Urology Sun Yat‐sen Memorial Hospital Sun Yat‐sen (Zhongshan) University Guangzhou China; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Sun Yat‐Sen Memorial Hospital Sun Yat‐Sen University Guangzhou China; Guangdong Provincial Clinical Research Center for Urological Diseases Guangzhou China Department of Statistics and Actuarial Science University of Iowa Iowa City Iowa USA Biodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, NC 27708, USA Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, China Center of Bioinformatics (COBI), Key Laboratory for NeuroInformation of Ministry of Education, University of Electronic Science and Technology of China, Chengdu 610054, China Department of Molecular Biology, Princeton University, Princeton, NJ 08544 Department of Biochemistry, Faculty of Medicine, Fukuoka University, Fukuoka, Japan. Department of Biological Sciences, University of Wisconsin, Milwaukee, Wisconsin 53211 (X.L., J.H., B.S., M.A., A.R., G.J., H.A.O., D.Z.); and Temasek Life Sciences Laboratory, National University of Singapore, Singapore 117604 (S.P., T.I.) Department of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region 530021, P.R. China Third Department of Hepatic Surgery China-Japan Research Institute of Medical and Pharmaceutical Sciences, Shenyang Pharmaceutical University, PR China. 1Department of Urology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, P.R. China.; 2Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, P.R. China. Shenzhen YiShengTang Biological Products Co. Ltd, Shenzhen 518026, China. China-Japan Research Institute of Medical and Pharmaceutical Sciences, Shenyang Pharmaceutical University, Shenyang, PR China. Department of Emergency, The First Affiliated Hospital of Soochow University, Suzhou, 215007, China Department of Orthopedic Surgery, Rush University Medical Center, Chicago, IL, USA Department of Molecular & Medical Pharmacology,University of California at Los Angeles, Los Angeles, California, USA Department of Obstetrics, Women’s Hospital, Zhejiang University, School of Medicine, Hangzhou, Zhejiang, China Center for Clinical Laboratories, the Affiliated Hospital of Guizhou Medical University, Guiyang, China Department of High Altitude Physiology and Pathology (Y.Y., J. Huang), College of High Altitude Military Medicine, Army Medical University (Third Military Medical University), Chongqing, China.; Key Laboratory of Extreme Environmental Medicine, Ministry of Education of China, Chongqing (S.W., Y.W., C.L., W.G., J. Hao, M.Z., G.W., Y.Y., J. Huang, B.N., D.C., Y.G.).; Key Laboratory of High Altitude Medicine, PLA, Chongqing, China (S.W., Y.W., C.L., G.X., W.G., J. Hao, M.Z., G.W., Y.Y., J. Huang, B.N., D.C., Y.G.). The Third Department of Hepatic Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China; Department of Anesthesia Southwest Hospital, Third Military Medical University Chongqing China Key Laboratory of Systems Biomedicine (Ministry of Education) Shanghai Centre for Systems Biomedicine Shanghai Jiao Tong University Shanghai China Key Laboratory of Microsystems and Microstructures Manufacturing; Ministry of Education; Harbin Institute of Technology; Harbin 150001; P. R. China Department of Materials Science & Engineering; CAS Key Lab of Materials for Energy Conversion; University of Science and Technology of China; Hefei, P. R. China Department of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory of Tumor Microenvironment and Inflammation Shanghai Jiao Tong University School of Medicine Shanghai 200025 China State Key Laboratory of Natural and Biomimetic Drugs, Institute of Ocean Research, Peking University, Beijing, 100191, People’s Republic of China Key Laboratory of Trace Element Nutrition of National Health Commission of the People’s Republic of China, Department of Food Science and Technology, National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, Beijing 100050, China Department of Biochemistry and Molecular Cell Biology Shanghai Key Laboratory of Tumor Microenvironment and Inflammation Shanghai Jiao Tong University School of Medicine Shanghai China Department of Oncology, Cancer Institute, The Second Affiliated Hospital Zhejiang University School of Medicine, 88 Jiefang Road, Hangzhou, Zhejiang 310009, China Department of Electrical and Computer Engineering, National University of Singapore, Singapore 117576, Singapore Department of Cardiac Surgery, Lanzhou University Second Hospital, Lanzhou University, Lanzhou, China; Laboratory of Extracorporeal Life Support, Lanzhou University Second Hospital, Lanzhou University, Lanzhou, China Department of Craniofacial Biology and Department of Cell and Developmental Biology, UCHSC at Fitzsimons, Mailstop 8120, P.O. Box 6511, Aurora, Colorado 80045; Department of Molecular, Cellular, and Developmental Biology, Yale University, 266 Whitney Ave., New Haven, Connecticut 06511 Department of Dermatology, Third Xiangya Hospital Central South University Changsha Hunan China Medtronic, Minneapolis, Minnesota Department of Medicinal Chemistry and Natural Medicine Chemistry, College of Pharmacy, Harbin Medical University, Harbin, PR China 1IARC, Lyon, France; Department of Clinical and Military Laboratory Medicine, College of Medical Laboratory Science, Army Medical University, 30 Gaotanyan Street, Shapingba District, Chongqing 400038, China Center of Bioinformatics (COBI), Key Laboratory for Neuroinformation of the Ministry of Education, Center for Information in BioMedicine, School of Life Science and Technology, University of Electronic Science and Technology of China (UESTC), Chengdu 610054, China AstraZeneca R&D Boston, Discovery Sciences, Waltham, Massachusetts, USA The Third Department of Hepatic Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438, China Department of Anesthesiology, Third People's Hospital of Guizhou Province, Guiyang 550008, China. Department of Urology Sun Yat‐Sen Memorial Hospital Sun Yat‐sen University Guangzhou China Shanghai Centre for Systems Biomedicine, Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Centre for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, China 1 School of Public Health, Yale University, New Haven, CT 06510, 2 Department of Statistics and Actuarial Science, University of Iowa, Iowa City, IA 52242, 3 Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA and 4 International Prevention Research Institute, Lyon, France Soochow University, Suzhou 215123, Jiangsu, China; First Department of Orthopedics, Affiliated Xiaolan Hospital Southern Medical University Zhongshan China Bioinfo Tech Incorporated Company, 10F Zhuangsen No.8 Dongsheng Street, Chengdu 610015, Sichuan Province,China. huangjian@bioinfochina.com Department of Statistics and Actuarial Science, Program in Public Health Genetics, University of Iowa 2 2 Iowa City, IA, USA Biochemistry Department, Affiliated Hospital of Guizhou Medical University, Guizhou, China; Center for Informational Biology, University of Electronic Science and Technology of China, Chengdu, Sichuan, China Key Laboratory for Liquid-Solid Structural Evolution and Processing of Materials, Ministry of Education, Shandong University, Jinan 250061, China Experimental Center, Beijing Friendship Hospital, Capital Medical University, Beijing, People’s Republic of China; National Clinical Research Center for Digestive Disease, Beijing Friendship Hospital, Capital Medical University, Beijing, People’s Republic of China Muscle Biology Research Group (MUBIG) School of Nursing & Health Studies University of Missouri–Kansas City Kansas City MO USA Department of Medicinal Chemistry and Natural Medicine Chemistry, College of Pharmacy HarBin Medical University HarBin People's Republic of China Department of Orthopedic Surgery, Rush University Medical Center, Chicago, Illinois Department of Organic and Polymer Chemistry; College of Chemistry and Chemical Engineering; Central South University; Changsha; China College of Life Sciences, Wuhan University, Bayi Road, Wuhan 430072, China College of Chemistry and Chemical Engineering Central South University Changsha 410083 China Department of Biochemistry and Molecular Cell Biology Shanghai Key Laboratory of Tumour Microenvironment and Inflammation Shanghai Jiao Tong University Shanghai China Department of Orthopedic Surgery Liaocheng People's Hospital Liaocheng China Department of Medicinal Chemistry and Natural Medicine Chemistry (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China), Harbin Medical University , Harbin 832001 , China;; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University , Shenyang 150081 , China; College of Chemistry and Chemical Engineering, Xi'an Shiyou University, Xi'an, Shaanxi 710065, China Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA. CAS Key Laboratory of Tropical Forest Ecology, Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences, Mengla 666303, China;; Center of Plant Ecology, Core Botanical Gardens, Chinese Academy of Sciences, Mengla 666303, China; Key Laboratory of Trace Element Nutrition of National Health Commission, National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, Beijing 100050, China Changsha Ruiyi Medical Technology Co., Ltd. Changsha People's Republic of China Department of Chemistry, Fudan University, 220 Handan Road, Shanghai 200433, China Department of Urology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China Department of Hematology, Wenzhou Central Hospital, Theorem Clinical College, Wenzhou Medical University, Wenzhou Experimental Center, Beijing Friendship Hospital, Capital Medical University , Beijing 100050, China; Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing Key Laboratory of Translational Medicine on Liver Cirrhosis , Beijing, China; Clinical Research Center for Rare Liver Diseases, Capital Medical University , Beijing, China; National Clinical Research Center for Digestive Diseases, On behalf of China Registry of Genetic/Metabolic Liver Diseases (CR-GMLD) Group , Beijing, China 2Department of Oncology, The 1st. Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province, China. From the Department of Internal Medicine (S.K., C.S.K., K.L.B., J.P., L.G., S.K.P., D.M.M.), University of Texas Health Science Center at Houston, Houston, TX; Department of Physiology (J.H., K.E.K., J.T.S.), University of Texas Southwestern Medical Center at Dallas, Dallas, TX; Department of Physiology (H.L.S.), University of Pennsylvania Perelman School of Medicine, Philadelphia, PA. State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, P.R. China Department of Internal Medicine, LSU Health Sciences Center, Shreveport, LA; Department of Organic and Polymer Chemistry, Hunan Key Laboratory of Micro & Nano Materials Interface Science, College of Chemistry and Chemical Engineering, Central South University, Changsha, Hunan 410083, China Division of Pharmaceutical Sciences and Department of Chemistry, 777 Highland Avenue, University of Wisconsin, Madison, Wisconsin 53705 State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116024, P.R. China Department of Urology; Sun Yat-Sen Memorial Hospital; Guangzhou China Chinese Center for Disease Control and Prevention National Institute for Nutrition and Health Beijing China Cancer Center Renmin Hospital of Wuhan University Wuhan Hubei P. R. China; Department of Urology Sun Yat‐sen Memorial Hospital Sun Yat‐sen University Guangzhou Guangdong P. R. China Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138 Department of Anesthesiology School of Materials Science and Chemical Engineering; Ningbo University; Ningbo; P. R. China Anhui Institute of Ecological Civilization, Anhui Jianzhu University, Hefei 230601, Anhui, P. R. China; Anhui Provincial Key Laboratory of Environmental Pollution Control and Resource Reuse, Anhui Jianzhu University, Hefei 230601, Anhui, P. R. China; School of Environment and Energy Engineering, Anhui Jianzhu University, Hefei 230601, Anhui, P. R. China Department of Laboratory Medicine, Affiliated Hospital of Zunyi Medical University, Zunyi, China Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China Department of Biological Sciences University of Illinois at Chicago Chicago Illinois USA Department of Urology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China; Key Laboratory of Malignant Tumor Gene Regulation and Target Therapy of Guangdong Higher Education Institutes, Sun Yat-sen University, Guangzhou, China Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan 430072, China Center of Bioinformatics (COBI), Key Laboratory for NeuroInformation of Ministry of Education, University of Electronic Science and Technology of China, Room 341, Yifu Building, Shahe Campus, No. 4, Section 2, North Jianshe Road, Chengdu, 610054, China, hj@uestc.edu.cn. 2Cancer Institute (Key Laboratory of Cancer Prevention & Intervention, National Ministry of Education; Provincial Key Laboratory of Molecular Biology in Medical Sciences), Zhejiang University, Hangzhou, China.; 7Department of Breast Surgery, Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang University, Hangzhou, China.; 8Key Laboratory of Tumor Microenvironment and Immune Therapy of Zhejiang Province, Zhejiang, China. Department of Urology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China State Key Laboratory of Translational Cardiovascular Medicine, Fuwai Hospital & Cardiovascular Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, 167 Bei-Li-Shi Road, Xi-Cheng District, Beijing 100037, China Department of Urology Sun Yat‐sen Memorial Hospital, Sun Yat‐sen University Guangzhou People's Republic of China; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Sun Yat‐sen Memorial Hospital, Sun Yat‐sen University Guangzhou People's Republic of China State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, P. R. China School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, People’s Republic of China Department of Medicinal Chemistry and Natural Medicinal Chemistry College of Pharmacy Harbin Medical University Harbin 150081 P. R. China College of Life Science, Wuhan University, Wuhan, Hubei, P.R. China School of Forensic Medicine, Kunming Medical University, Kunming, Yunnan, China The Third Department of Hepatic Surgery Eastern Hepatobiliary Surgery Hospital Shanghai China State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences Fuzhou 350002 P. R. China; College of Chemistry and Materials Science Fujian Normal University Fuzhou 350007 P. R. China Department of Urology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510120, China. Department of Oncology, Liuzhou City Workers Hospital, The Fourth Affiliated Hospital of Guangxi Medical University, Liuzhou 545000, China School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, 110016, China Department of Civil Engineering, School of Environment and Architecture, University of Shanghai for Science and Technology, Shanghai 200093, China Muscle Biology Research Group, Schools of Nursing & Health StudiesUniversity of Missouri Kansas CityKansas CityMOUSA Fuwai Heart Disease Hospital, CAMS and PUMC, Beijing, China Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Department of Radiation Oncology Liuzhou Worker Hospital Liuzhou Guangxi Province People's Republic of China Department of Cardiology, The Second Affiliated Hospital of Soochow University, Jiangsu, China. Department of Medicinal Chemistry and Natural Medicine Chemistry (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China), Harbin Medical University, Harbin 150081, China. National Key Laboratory of Green Pesticide, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education Center for R&D of Fine Chemicals of Guizhou University Guiyang China Department of Emergency Medicine, Academy of Medical Sciences and Sichuan Provincial People’s Hospital, Chengdu, Sichuan, China (mainland) Department of Orthopedics, The First Affiliated Hospital, Anhui Medical University, Hefei, China. Laboratory of Molecular Immunoregulation, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute-Frederick , Frederick, Maryland , USA Department of Andrology, Jiangsu Provincial Hospital of Traditional Chinese Medicine, Nanjing, Jiangsu 210029, China. njnjhj@yahoo.com.cn Division of Pharmaceutical Sciences and Department of Chemistry, University of Wisconsin, Madison, Wisconsin 53705 School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 610054. Department of Obstetrics and Gynecology, Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China. huangjian2566@hotmail.com Key Laboratory of the Ministry of Education for Image Processing and Intelligent Control, School of Artificial Intelligence and Automation, Huazhong University of Science and Technology, Wuhan, China Department of National Drug Clinical Trial Research Center Xiangya Boai Rehabilitation Hospital Changsha People's Republic of China Zhejiang Kaishan Compressor Co., Ltd. The State Key Laboratory of Polymer Materials Engineering, Polymer Research Institute of Sichuan University, Chengdu 610065, China Department of Urology, Minimally Invasive Surgery Center, The First Affiliated Hospital of Guangzhou Medical University, Guangdong Key Laboratory of Urology, Guangzhou Institute of Urology, Guangzhou, China. huangjianmnwk@163.com. School of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, Jiangsu, China Center for Informational Biology, University of Electronic Science and Technology of China, Chengdu, China Key Laboratory of Tumor Microenvironment and Immune Therapy of Zhejiang Province, Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang University , Hangzhou, China; Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, National Ministry of Education), Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang University , Hangzhou, China; Department of Breast Surgery, Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang University , Hangzhou, China Key Laboratory for Neuro-Information of Ministry of Education , School of Life Science and Technology, Center for Informational Biology, University of Electronic Science and Technology of China, Chengdu 610054, China University College Cork, School of Mathematical Sciences, Cork University of Pennsylvania, Philadelphia, PA, USA Departments of Physiology and Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390 School of Materials Science and Engineering Shanghai University 200436 Shanghai PR China; Shaoxing Institute of Technology Shanghai University 312000 Shaoxing PR China; Zhejiang Institute of Advanced Materials Shanghai University 314113 Jiashan PR China Department of Nephrology, Jinhua Municipal Central Hospital, Jinhua, China Biodemography of Aging Research Unit, Social Science Research Institute Duke University Durham North California Authors' Affiliations: Departments of 1Pharmacology and Therapeutics and 2Medicine, McGill University Health Centre, Montreal; 3McGill Centre for Bioinformatics; and 4Sackler program for Psychobiology and Epigenetics at McGill University, Montreal, Quebec, Canada; 5Department of Nutrition Science, Purdue University, West Lafayette, Indiana; 6Shanghai-MOST Key Laboratory for Disease and Health Genomics, Chinese National Human Genome Center at Shanghai, Shanghai, China; 7Department of Hepatology, Bangabandhu Sheikh Mujib Medical University; 8International Centre for Diarrhoeal Diseases Research, Bangladesh (icddr,b), Dhaka, Dhaka District, Bangladesh; 9Department of Medical Sciences, Toshiba General Hospital, Tokyo, Kanto, Japan; and 10Department of Pathology, Fatima Memorial Hospital College of Medicine and Dentistry Lahore, Pakistan Department of Urology, Sun Yat-sen Memorial Hospital; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Guangzhou, China Key Laboratory of Basic Research in Cardiology of the Ministry of Education of China Tongji University Shanghai China; Institute of Medical Genetics Tongji University Shanghai China; Department of Cardiology East Hospital Tongji University Shanghai China Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education) Department of Chemistry Tsinghua University Beijing 100082 China; School of Pharmaceutical Sciences Tsinghua University Beijing 100082 China; Tsinghua University‐Peking University Joint Center for Life Sciences and Beijing Advanced Innovation Center for Structural Biology Tsinghua University Beijing 100082 China College of Life Science, Qingdao Ocean University, Qingdao 266003. Jianh@qingdao.cngb.com Department of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory of Tumor Microenvironment and Inflammation Shanghai Jiao Tong University School of Medicine China Experimental Center, Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, P.R. China Department of Thoracic Surgery, Jiangxi Cancer Hospital, Nanchang, Jiangxi 330029, China Department of Oncology Liuzhou Worker's Hospital Liuzhou Guangxi China Bone Muscle Research Center, College of Nursing and Health Innovations, Department of Graduate Nursing, University of Texas at Arlington, Arlington, Texas, USA. College of Forestry, Northwest A & F University, Yangling, China Key laboratory of Ministry of Education and Sichuan Province for Qinghai-Tibetan Plateau Animal Genetic Resource Reservation and Utilization, Chengdu 610041, PR China; College of Animal and Veterinary Sciences, Southwest Minzu University, Chengdu 610041, PR China 1Takeda Development Center Americas, Inc. (TDCA), Lexington, Massachusetts. Department of Biostatistics Department of Statistics and Actuarial Science, and Department of Psychiatry The University of Iowa Iowa City, Iowa Kunshan Mental Health Center Suzhou China Department of Biochemistry, Guilin Medical College, Guilin 541004, China. huangjian730@yahoo.com.cn Department of Medicine, Louisiana State University Health Sciences Center, Shreveport College of Forestry, Northwest A&F University, Yangling 712100, China Department of PathologyTemple University School of MedicinePhiladelphiaPennsylvaniaUSA University of Science and Technology of China; Chinese Academy of Sciences; Advanced Laser Technology Laboratory of Anhui Province College of Forestry, Northwest A&F University, Yangling, China; State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, People’s Republic of China Key Laboratory of Trace Element Nutrition of National Health and Family Planning Commission of the People's Republic of ChinaNational Institute for Nutrition and HealthChinese Center for Disease Control and Prevention Beijing China Soochow University, Institutes of Biology and Medical Sciences, Suzhou, China School of Mathematical Sciences, University College Cork, T12 YN60 Cork, Ireland Cancer Research Institute, Xiang-Ya School of Medicine, Central South University, Changsha, Hunan Province, China. From the Departments of Medicine, Division of Cardiovascular Diseases (J.H., G.P.W., R.E.I.), Biomedical Engineering (R.E.I.), and Physiology (R.E.I.), University of Alabama at Birmingham, and Ruse Technologies, LLC, Atlanta, GA (R.B.R., S.J.B.). Department of Breast Medical Oncology Zhejiang Cancer Hospital Hangzhou China Department of Urology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China. Department of Biochemistry and Molecular Cell Biology & Shanghai Key Laboratory of Tumor Microenvironment and Inflammation Shanghai Jiao Tong University School of Medicine (SJTU‐SM) Shanghai China Chengdu Anticancer Bioscience, J. Michael Bishop Institute of Cancer Research, Chengdu, Sichuan 610000, China Medical Laboratory Education Center, College of Medicine, Nanchang University, Nanchang 330006, China. Department of Anesthesiology, Zhongshan Hospital Fudan University, Shanghai, China 1Dermatology and Immunology and Departments of Clinical Laboratory Center, Guangxi Medical University First Affiliated Hospital, Nanning, China. School of Biology & Basic Medical Science, Soochow University, 199 Ren'ai Road, Suzhou, 215123, Jiangsu, China School of Forensic Medicine, Southern Medical University, Guangzhou 510515, Guangdong, China School of Materials Science and Engineering, Shanghai University, Shanghai 200444, People’s Republic of China Department of Veterinary Clinical Science, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China.; Department of Veterinary Science, College of Life Science and Technology, Southwest University for Nationalities, Chengdu 610041, China. Department of Urology, Sun Yat‑Sen Memorial Hospital, Sun Yat‑Sen University, Guangzhou, Guangdong 510120, P.R. China Intensive Care Unit, Daping Hospital Third Military Medical University, Chongqing 400042, PR China. State Key Laboratory of Translational Cardiovascular Medicine, Fuwai Hospital and Cardiovascular Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China. Key Laboratory for Green Chemistry of Jiangxi Province, College of Chemistry and Chemical Engineering, Jiangxi Normal University, Nanchang, 330022, China From the Institut Cardiovasculaire Paris Sud, Hopital Privé Jacques Cartier, Générale de santé, Massy, France (M.-C.M.); Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands (P.W.S., A.P.K.); Evanston Hospital, Evanston, IL (T.E.F.); University Hospital Uppsala, Uppsala, Sweden (E.S.); San Raffaele Scientific Institute, Milan, Italy (A.C.); Medical City Hospital, Dallas, TX (M.J.M.); Mayo Clinic, Rochester, MN (D.R.H.); Baylor Heart and Vascular Hospital, Dallas, TX (J.W.C.);... Department of Emergency The First Affiliated Hospital of Soochow University Suzhou China Departments of Chemistry, ‡Biosciences and §Discovery Sciences, Infection Innovative Medicines Unit, AstraZeneca R&D Boston, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States Departments of Statistics and Actuarial Science, and Biostatistics, University of Iowa, Iowa City, IA 52242-1409, USA. Department of Hematology, Wenzhou Central Hospital, Dingli Clinical Medical School of Wenzhou Medical University , No. 252, Baili East Road, Lucheng District , Wenzhou 32500 , Zhejiang Province , China Department of Urology, Sun Yat-sen Memorial Hospital of Sun Yat-sen University; and Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangzhou, China. College of Plant Protection Fujian Agricultural and Forestry University Fuzhou Fujian China Department of Urology, Sun Yat‐sen Memorial Hospital Sun Yat‐sen University Guangzhou China Division of Pharmaceutical Sciences and Department of Chemistry, University of Wisconsin, Madison, Wisconsin 53705, and Department of Chemistry, Roy and Diana Vagelos Laboratories, University of Pennsylvania, Philadelphia, Pennsylvania 19104 Discovery Sciences, AstraZeneca R&D Boston, Waltham, MA 02451; Department of Stomatology, The Fourth Affiliated Hospital of Harbin Medical University, Harbin 150001, China. huangjian1995@yahoo.cn State Key Laboratory of Inorganic Synthesis & Preparative Chemistry, Jilin University, 2699 Qianjin Street, 130012 Changchun, China Department of Surgical Oncology, Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang University, Hangzhou, 310009, China; Cancer Institute, Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang University, Hangzhou, 310009, China Department of Breast Medical Oncology, Zhejiang Cancer Hospital, Hangzhou, Zhejiang 310022, P.R. China Center for Informational Biology, University of Electronic Science and Technology of China , Chengdu, Sichuan 611731, China Department of Statistics, University of Iowa, U.S.A. Departments of Statistics & Actuarial Science, and Biostatistics University of Iowa Iowa City Iowa Department of Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, P.R. China Department of Pathology and Pathophysiology and Department of Surgical Oncology (Breast Center), The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China 1 Key Laboratory for Neuro-Information of Ministry of Education, School of Life Science and Technology, Center for Informational Biology, University of Electronic Science and Technology of China, Chengdu, China 1Immunology, Departments of Department of Hematology, The Fourth Affiliated Hospital, College of Medicine, Zhejiang University, Yiwu 322000, P.R. China Shanghai-MOST Key Laboratory for Disease and Health Genomics; Chinese National Human Genome Center at Shanghai; Shanghai China Department of Hygiene, Nagoya University School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466 Wuxi Lung Transplant Center, Wuxi People's Hospital Affiliated to Nanjing Medical University, Wuxi, Jiangsu 214023, China Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China. Department of Organic and Polymer Chemistry, College of Chemistry and Chemical Engineering, Central South University, Changsha, Hunan 410083, China Jiangxi Key Laboratory for Mass Spectrometry and Instrumentation, Jiangxi Province Key Laboratory of Synthetic Chemistry, East China University of Technology, Nanchang 330013, China College of Life Sciences, Fujian Normal University, Fujian Key Laboratory of Developmental and Neurological Biology, Fuzhou 350117, China. Key Laboratory of Tropical Forest Ecology, Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences, Mengla 666303, China The State Key Lab of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Science, 585 Heshuo Road, Shanghai201800, PR China College of Life Sciences, Wuhan University, Wuhan, 430072, China Department of Pathology, Huai'an First People's Hospital, Nanjing Medical University, Huai'an, Jiangsu Province, China Liver Research Center, Experimental Center, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, P.R. China Department of Emergency Medicine, The First Affiliated Hospital of Suzhou University, Suzhou, China. Department of Urology, Sun Yat-sen Memorial Hospital, Sun Yat-sen (Zhongshan) University, Guangzhou, People's Republic of China Departments of3 Medicine, From the Departments of Medicine (X.Z., J.H., S.M.P., R.E.I.), Biomedical Engineering (S.M.P.), and Physiology (S.M.P.), University of Alabama at Birmingham; and Department of Internal Medicine, CARMA Center, University of Utah, Salt Lake City (L.L., D.J.D.). School of Traditional Chinese Medicines, Shenyang Pharmaceutical University, No.103, Wenhua Road, Shenhe District, Shenyang City, People's Republic of China, 110016 College of Material Science and Engineering, Nanjing Tech University, Nanjing 210009, China Department of General Practice, Jiangping Health Station of Dongxing City Dongxing, China. Statistical Services, Medtronic, Minneapolis, Minnesota. School of Forensic Medicine Kunming Medical University Kunming China Department of Electrical and Computer Engineering, National University of Singapore, Singapore, 117576 Department of Pharmacy, People’s Hospital of Deyang City, Deyang, P.R. China State Key Laboratory of Silicate Materials for Architectures, Wuhan University of Technology, Wuhan 430070, P. R. China Department of Hematology, Institute of Hematology; The First Affiliated Hospital of Zhejiang University, School of Medicine; Hangzhou Zhejiang Province China College of Liberal Arts and Science, National University of Defense Technology, Changsha 410073, China Reagents and Assay Development, Discovery Sciences, AstraZeneca Pharmaceuticals, Waltham, MA 02451; Laboratory of Tumor Immunobiology, Cancer Research Institute, Xiang-Ya School of Medicine, Central South University, Changsha 410078, China. xyhuangjian@163.com Wuxi Lung Transplant Center, Wuxi People’s Hospital Affiliated with Nanjing Medical University, Wuxi, Jiangsu, China (mainland) PPD Wilmington North Carolina State Key Laboratory of Inorganic Synthesis & Preparative Chemistry, Jilin University, 2699 Qianjin Street, Changchun 130012, P. R. China |
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