http://rdf.ncbi.nlm.nih.gov/pubchem/author/MD5_e7ba9593857bc3aa24428889811a6076
Outgoing Links
Predicate | Object |
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family-name | Yang Yan Yang |
name | Yan Yang |
given-name | Yan |
organization-name | Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China. College of Basic Medicine, Nanjing University of Chinese Medicine, 138 Xianlin Road, Nanjing 210023, China Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Guangzhou, Guangdong Province, P. R. China; Guangdong Engineering Technology Center of Nutrition Transformation, Guangzhou, Guangdong Province, P. R. China; Department of Nutrition, School of Public Health (Shenzhen), Sun Yat-sen University, Shenzhen, Guangdong Province, P. R. China Department of Respiratory and Critical Care Medicine, Sichuan Academy of Medical Sciences and Sichuan Provincial People’s Hospital, Sichuan, P.R. China Institute of Genomic Medicine Research, College of Pharmacy, Jinan University, Guangzhou, 510632, PR China The Institute of Hypertension and Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, China Division of Endocrinology and Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Hubei, Wuhan 430079, P. R. China, and Hubei Key Laboratory of Pollutant Analysis & Reuse Technology, Hubei Normal University, Huangshi 435002, P. R. China Institute of Dermatology, Guangzhou Medical University , Guangzhou, China; Department of Dermatology, Guangzhou Institute of Dermatology , Guangzhou, China Institute of Biomedicine and Guangdong Provincial Key Laboratory of Bioengineering Medicine Jinan University Guangzhou P.R. China State Key Laboratory of Powder Metallurgy Central South University Changsha Hunan China; State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Preventive Dentistry, West China Hospital of Stomatology Sichuan University Chengdu China; Xiangya Stomatological Hospital, Xiangya School of Stomatology Central South University Changsha Hunan China Food safety and Quality Control Innovation team, Department of Food Science and Engineering School of Food and Biological Engineering, Shaanxi University of Science and Technology Xi'an 710021 China Laboratory Medicine, The Huikang Hospital of Qingdao University Medical Group, Qingdao, 266520 Shandong, China School of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, China. Fujian Provincial Key Laboratory of Zoonosis Research (Fujian Center for Disease Control & Prevention) Fuzhou P. R. China Department of Endocrinology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei,China Maternal and Child Health Hospital of Zhuang Lang Pingliang China Department of Pathology, Wayne State University School of Medicine, Detroit; and Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan School of Materials Science and Engineering, Chongqing University of Technology, Chongqing 400054, China School of Chemistry, South China Normal University, Guangzhou 510006, P. R. China Center for Molecular and Human Genetics, Columbus Children's Research Institute, Department of Molecular Virology, Immunology and Medical Genetics, Ohio State University, Columbus, Ohio, USA. From the Key Laboratory of Medical Electrophysiology, Ministry of Education of China, and the Institute of Cardiovascular Research, Luzhou Medical College, Luzhou, Sichuan, China. Key Laboratory for Chinese Medicine of Prevention and Treatment in Neurological Diseases, Nanjing University of Chinese Medicine, 138 Xianlin Rd, Nanjing, 210023 Jiangsu, China; School of Medicine and Life Sciences, Nanjing University of Chinese Medicine, 138 Xianlin Rd, Nanjing, 210023 Jiangsu, China Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China 1Dalton Cardiovascular Research Center Department of Endocrinology, Third Xiangya Hospital, Central South University, Changsha 410013, China. Sichuan Jinxin Xinan Women & Children Hospital (Jingxiu District), Chengdu, Sichuan, China National Engineering Research Center of Edible Fungi, Key Laboratory of Applied Mycological Resources and Utilization, Ministry of Agriculture, Shanghai Key Laboratory of Agricultural Genetics and Breeding, Institute of Edible Fungi, Shanghai Academy of Agricultural Sciences, Shanghai 201403, China Department of Pharmacology and Institute of Natural Medicine Anhui Medical University Hefei China Department of Medical Microbiology and Immunology, School of Basic Medical Science, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis (Ministry of Education), Key Laboratory of Chemical Biology of Hebei Province, Medical Comprehensive Experimental Center, Hebei University, Baoding 071002, China Department of Chemistry, Beijing Key Laboratory of Microanalytical Methods and Instrumentation, Tsinghua University, Beijing, 100084, P.R. China Zhejiang University School of Medicine; Hangzhou Binjiang Hospital, Hangzhou, Zhejiang, China. Institute for Human Infections and Immunity and Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas 77555-1073 School of Computing and Artificial Intelligence, Southwest Jiaotong University, Chengdu 611756, Sichuan, China; Artificial Intelligence Research Institute, Southwest Jiaotong University, Chengdu 611756, Sichuan, China The Comprehensive Cancer Centre of Drum Tower Hospital, Medical School of Nanjing University & Clinical Cancer Institute of Nanjing University, Nanjing, China Beijing Weather Modification Office, Beijing 100089, China Department of Thoracic Surgery Shanghai Key Lab of Tuberculosis Shanghai Pulmonary Hospital School of Life Science and Technology Tongji University Shanghai 200433 P. R. China Department of Surgery, Fuwai Hospital, CAMS&PUMC (Y.Y.) Department of Endocrinology, The Fifth Medical Center of Chinese PLA Hospital, Beijing, China School of Chemical Engineering; Nanjing University of Science and Technology; Nanjing 210094; China Department of Neurology, Affiliated Hospital of Jining Medical University, Jining, China Department of Pediatrics (Children Hematological Oncology), Birth Defects and Childhood Hematological Oncology Laboratory, The Affiliated Hospital of Southwest Medical University, Sichuan Clinical Research Center for Birth Defects, Luzhou, Sichuan, China Biology Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250103, China; Shandong Provincial Key Laboratory of Biosensors, Jinan 250103, China SP Group–NTU Joint Laboratory, School of Electrical and Electronic Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798, Singapore Kidney Research Institute, Division of Nephrology, West China Hospital, Sichuan University, Chengdu, Sichuan, China Palo Alto Medical Foundation Research Institute, Palo Alto, California Gastroenterology Department of People’s Hospital of Baoshan City, Baoshan City, Baoshan, China Key Laboratory of Theoretical Organic Chemistry and Functional Molecules, Ministry of Education, and School of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan 411201, China Prenatal Diagnosis Center of Jiangxi Women and Children's Hospital, Nanchang, Jiangxi 330006, China. lyq0914@126.com. Division of Nephrology, Peking University Shenzhen Hospital, China; Shenzhen Luohu District Traditional Chinese Medicine Hospital, China State Key Laboratory of Transducer Technology, Aerospace Information Research Institute, Chinese Academy of Sciences, Beijing 100190, China; School of Electronic, Electrical and Communication Engineering, University of Chinese Academy of Sciences, Beijing 100049, PR China Department of Surgery (M.T., X.W., H.S., W.F., Y.S., F.L., L.W., Y.Y., S.G., Z.S., K.L., C.Z., Yue Wu, H.X., W.Z., C.H., X.Z., E.W., X.H., S.H.), Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. Department of Geriatric Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, China Department of Pharmacology and Institute of Natural Medicine, Anhui Medical University, Hefei, Anhui 230032, P.R. China Department of Cell Biology Jinan University Guangzhou 510632 China; Guangdong Province Key Laboratory of Bioengineering Medicine Jinan University Guangzhou 510632 China for the OPTIMAL Study Group School of Pharmacy, Inner Mongolia Medical University, Huhhot, China College of Basic Medicine, Nanjing University of Chinese Medicine, 138 Xianlin Rd, Nanjing 210023, Jiangsu, China School of Science, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, Jiangsu 211198, China Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia; Alfred Heart Centre, The Alfred Hospital, Melbourne, Victoria, Australia Department of Hepatobiliary Pancreatic Surgery First Affiliated Hospital of Hainan Medical University Haikou Hainan China Department of Obstetrics and Gynaecology West China Second University Hospital, Sichuan University Chengdu China; Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education Sichuan University Chengdu China School of Economics and Management Tongji University Shanghai China Institude of Advanced Studies; Wuhan University; Wuhan 430072; China Department of Nephrology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China; Department of Pharmaceutics, School of Pharmacy Center for Nano Drug/Gene Delivery and Tissue Engineering, Jiangsu University Zhenjiang People's Republic of China Department of Nephrology Southwest Hospital Army Medical University Chongqing China College of Medicine, Jiaxing University, 118 Jiahang Road, Jiaxing, Zhejiang 314001, People’s Republic of China Department of Aesthetic and Reconstructive Breast Surgery Department of Pain Management, Anesthesiology Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA Department of Pharmacology; Anhui Medical University; Hefei, China Experimental Medical Research Center, Division of Clinical Immunology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian 116023, P. R. China State Key Laboratory of Structure Chemistry; Fujian Institute of Research on the Structure of Matter; Chinese Academy of Sciences; Fuzhou; China Department of Pathology, Cancer Hospital (Institute), Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China. Department of Geriatrics, First Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu 210029, China; Department of Tuberculosis, The Second Hospital of Nanjing, Nanjing, Jiangsu 210003, China Transformation Engineering Research Center of Chronic Disease Diagnosis and Treatment, Guizhou Medical University, Guiyang, Guizhou, China; Department of Physiology, School of Basic Medicine, Guizhou Medical University, Guiyang, Guizhou, China; Internal medicine, The Third Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China Department of Chemistry, Southern Methodist University, Dallas, Texas 75275, and W. M. Keck Foundation Center for Molecular Structure and Department of Chemistry and Biochemistry, California State UniversityFullerton, Fullerton, California 92834 The First Clinical Medical College of Lanzhou University, Gansu Provincial Cancer Hospital, Lanzhou, Gansu 730050, P.R. China Department of Echocardiography Beijing Anzhen Hospital Capital Medical University and Beijing Institute of Heart Lung and Blood Vessel Diseases Hao Beijing People's Republic of China State Key Laboratory of Transducer Technology, Aerospace Information Research Institute, Chinese Academy of Sciences, Beijing 100190, China; University of Chinese Academy of Sciences, Beijing 100049, China State Key Laboratory of Virology, Institute of Medical Virology, Wuhan University School of Basic Medical Sciences, Wuhan, Hubei 430071, China; Shenzhen R and D Center of State Key Laboratory of Virology, Wuhan University Shenzhen Institute, Shenzhen, Guangdong 518057, China Department of Nuclear Medicine, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China College of Materials Science and Engineering, Central South University of Forestry and Technology, Changsha 410004, China Institute of Edible Fungi, Shanghai Academy of Agricultural Sciences, Key Laboratory of Edible Fungi Resources and Utilization (South), Ministry of Agriculture, Shanghai 201403, P.R. China; National Engineering Research Center of Edible Fungi, No. 1000 Jinqi Road, Shanghai 201403, P.R. China Department of Pharmacology, Institute of Natural Medicine, Anhui Medical University, Hefei, Anhui 230032, P.R. China Institute of Edible Fungi, Shanghai Academy of Agricultural Sciences, National Engineering Research Center of Edible Fungi, Key Laboratory of Edible Fungi Resources and Utilization (South), Ministry of Agriculture, People's Republic of China, Shanghai Guosen Bio‐tech Co. Ltd 1000 Jinqi Road Shanghai China Dalton Cardiovascular Research Center, University of Missouri, Columbia, Missouri Department of Cardiology, The Second Affiliated Hospital of North Sichuan Medical College (Mianyang 404 Hospital), Mianyang, SiChuan, China Department of Laboratory, First Affiliated Hospital, School of Medicine Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724 (A.G., Y.Y., D.J.); University of California San Diego, La Jolla, California 92093–0116 (A.G., R.J.S.); and University of Amsterdam, Amsterdam 1098SM, The Netherlands (Y.Y.) Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA. gtg929i@mail.gatech.edu Department of Nephrology The First People's Hospital of Changzhou The Third Hospital Affiliated to Soochow University Changzhou China Department of Pharmacology, Anhui Medical University, Hefei, China. yangyan@ahmu.edu.cn. Department of Hematology in Caner Center, The First Hospital of Jilin University, Changchun, Jilin, China Tobacco Control Office, Chinese Center for Disease Control and Prevention, Beijing 100050, China; Email: yangyan8288@hotmail.com. Department of Medical Oncology, First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui, China Centre for Neuroscience, Zhejiang University School of Medicine, Hangzhou 310016, P.R. China Heilongjiang University of Chinese Medicine Harbin China Meteorological Medical Research Center, Panzhihua Central Hospital, Panzhihua, China; Department of Respiratory and Critical Care Medicine, Panzhihua Central Hospital, Panzhihua, China Center for Hepatitis Research, Institute for Human Infections and Immunity, and the Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas 77555-1073 School of Environmental Science and Engineering, Huazhong University of Science and Technology, Wuhan, China School of Engineering and Materials Science Queen Mary University of London London E1 4NS UK Institute of Advanced Studies; Wuhan University; Wuhan 430072; China Department of Endocrinology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China Department of Emergency Medicine, The First People’s Hospital of Yunnan Province, Kunming, China Tobacco Control Office, Chinese Center for Disease Control and Prevention China Department of Dermatology; Shanghai Ninth People's Hospital; Shanghai Jiaotong University School of Medicine; Shanghai 200011; China Department of Rehabilitation Medicine Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China Chengdu China Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education School of Life Sciences Changchun 130012 China Department of Nutrition and Food Safety, School of Public Health (Shenzhen), Sun Yat-sen University, Guangzhou, Guangdong Province, China; Guangdong Provincial Key Laboratory for Food, Nutrition and Health, Guangzhou, Guangdong Province, China; Guangdong Engineering Technology Research Center of Nutrition Translation, Guangzhou, Guangdong Province, China Jiangsu Key Laboratory of Materials and Technology for Energy Conversion, College of Materials Science & Technology, Nanjing University of Aeronautics & Astronautics, Nanjing 210016, China Department of Pathology, Wayne State University, School of Medicine, Detroit, Michigan Shanghai Jiao Tong University School of Medicine Affiliated Renji Hospital Shanghai China Department of General Surgery, Jiangdu People's Hospital Affiliated to Yangzhou University, Yangzhou, China Department of Stomatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei430030, P.R. China Center for Hepatitis Research, Institute for Human Infections and Immunity, Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555-1019 Department of Chemistry, Tsinghua University, Beijing, 100084, People's Republic of China College of Horticulture, Gansu Agricultural University, Lanzhou 730070, China Division of Endocrinology Tongji Hospital Huazhong University of Science & Technology Wuhan 430030 P.R. China Foshan University, Foshan 528225, China Guangdong-Hong Kong-Macao Joint Laboratory for Contaminants Exposure and Health, Guangdong Key Laboratory of Environmental Catalysis and Health Risk Control, Institute of Environmental Health and Pollution Control, Guangdong University of Technology, Guangzhou 510006, P. R. China; Guangzhou Key Laboratory of Environmental Catalysis and Pollution Control, Guangdong Technology Research Center for Photocatalytic Technology Integration and Equipment Engineering, School of Environmental Science and Engineering, Guangdong University of Technology, Guangzhou 510006, P. R. China; Synergy Innovation Institute of GDUT, Shantou 515041, P. R. China Dalton Cardiovascular Research Centre University of Missouri Columbia MO 65211 USA Department of Molecular Microbiology, Washington University in St. Louis, St. Louis, MO, USA Jin Li, Weijian Guo, Xiaodong Zhu, Dongmei Ji, and Xin Liu, Shanghai Cancer Center and Shanghai Medical College, Fudan University; Liwei Wang, Shanghai First People's Hospital; Leizhen Zheng, XinHua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai; Shukui Qin, The 81 Hospital of PLA, Nanjing; Hao Yu, School of Public Health, Nanjing Medical University, Nanjing; Jianming Xu, The 307 Hospital of the Academy of Military Medical Sciences, Beijing; Jianping Xiong, The First... National Clinical Research Center for Metabolic Diseases, Metabolic Syndrome Research Center, Key Laboratory of Diabetes Immunology, Ministry of Education, and Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University, Changsha 410011, Hunan, China Institute of Genomic Medicine Research, College of Pharmacy, Jinan University, Guangzhou, 510632, People's Republic of China. Emergency Department, The Second Clinical Medical College, Shanxi Medical University, Taiyuan, Shanxi Province, China. Department of Chemistry; Tsinghua University; Beijing; China Department of Nutrition; School of Public Health; Sun Yat-Sen University; Guangzhou; P. R. China Department of Cardiovasology, Shijiazhuang People’s Hospital, Shijiazhaung, HB, China Department of Spine Surgery, Xiangya Hospital, Central South University, Changsha 410008. 1984575043@qq.com. Key Laboratory of Organ Injury, Aging and Regenerative Medicine of Hunan Province, Changsha 410008. 1984575043@qq.com. National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha 410008, China. 1984575043@qq.com. Institute of Edible Fungi Shanghai Academy of Agricultural Sciences National Engineering Research Center of Edible Fungi Key Laboratory of Edible Fungi Resources and Utilization (South) Ministry of Agriculture Shanghai China; Shanghai Guosen Bio‐tech Co. Ltd. Shanghai China Department of Hematology and Hematology Research Institute West China Hospital, Sichuan University Chengdu People's Republic of China Y Yang, Veterinary Medicine, South China Agricultural University, Guangzhou, China Department of Pathology and Wayne State University School of Medicine 1 , Detroit, MI 48201, USA Department of Orthopaedics, the First Affiliated Hospital of China Medical University, Shenyang Liaoning, 110001, P.R.China. The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Ophthalmology and Chongqing Eye Institute, Chongqing, People's Republic of China 2Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, People's Republic Department of Spine Surgery, Xiangya Hospital, Central South University, Changsha 410008, Hunan, People’s Republic of China; Hunan Engineering Laboratory of Advanced Artificial Osteo-Materials, Xiangya Hospital, Central South University, Changsha 410008, Hunan, People’s Republic of China Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi 214122, China School of Environmental Science & Engineering, Huazhong University of Science and Technology, Wuhan, People’s Republic of China Key Laboratory of Medical Electrophysiology of Ministry of Education and Medical Electrophysiological Key Laboratory of Sichuan Province, Collaborative Innovation Center for Prevention and Treatment of Cardiovascular Disease, Institute of Cardiovascular Research, Southwest Medical University, 319 Zhongshan Road, Luzhou 646000, China Department of Radiation Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China. Department of General Surgery, The Second Affiliated Hospital of Guangxi Medical University, Nanning 530007, China Department of Diagnosis, The First Clinical Medical College of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China LPCNO, Université de Toulouse, INSA, UPS, LPCNO, 135 avenue de Rangueil, F-31077 Toulouse, France, and CNRS, LPCNO, F-31077 Toulouse, France LPCNO, Université de Toulouse, INSA, UPS, Toulouse, France Department of Schistosomiasis and Endemic Diseases, Wuhan City Center for Disease Prevention and Control, Wuhan, China Atom Bioscience and Pharmaceutical Co., Ltd. Zhenjiang China College of Life Sciences, Shaanxi Normal University, Xi’an, China; Department of Neurobiology, Duke University School of Medicine, Durham, United States Department of Preventive Medicine, School of Public Health, Fujian Medical University , Fuzhou, Fujian Province, China Department of Surgical Oncology The First Affiliated Hospital Zhejiang University School of Medicine Hangzhou Zhejiang 310003 China State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China. Department of Chemistry, East China Normal University, 500 Dongchuan Road, Shanghai, 200241, P.R. China Guangdong Provincial Key Laboratory of Advanced Energy Storage Materials School of Materials Science and Engineering South China University of Technology Guangzhou 510641 China Department of Medical Oncology, First Affiliated Hospital of Bengbu Medical College, Bengbu 233004, Anhui, China Integrated Circuit Advanced Process Center, Institute of Microelectronics, Chinese Academy of Sciences, Beijing 100029, China Laboratory of Molecular Immunoregulation, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland; College of Marine Life Sciences, Ocean University of China, Qingdao, China. University of Alberta, Department of Agricultural, Food and Nutritional Science, Edmonton, Alberta, Canada School of Chemistry and Chemical Engineering and School of Materials Science and Engineering Nanjing University of Science and Technology Nanjing 210094 China Department of School of Computer Science and Technology, East China Normal University; Shanghai Key Laboratory of Multidimensional Information Processing, Shanghai, People’s Republic of China Department of Horticulture, Zhejiang University, Hangzhou, People’s Republic of China 310029 (Y.C., Y.Z., Y.Y., Y.-J.C., J.Z., K.S., Y.-H.Z., J.-Q.Y., Z.C.); and Department of Botany and Plant Pathology, Purdue University, West Lafayette, Indiana 47907–2054 (Y.C., J.Z., J.-Y.C., F.W., B.F., Z.C.) Department of Anesthesiology, The First People's Hospital, Wuhan, Hubei 430200, P.R. China Department of Radiation Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu 610041, China. Department of Ophthalmology, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, China Health Management Center, QiLu Hospital of Shandong University, Jinan, Shandong Province Division of Endocrinology, Tongji Hospital, Tongji Medical College of Huazhong University of Science & Technology, Wuhan, People's Republic of China. Department of Oral and Maxillofacial Surgery Nanjing Stomatological Hospital Medical School of Nanjing University Nanjing China School of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou 510006, China; Jieyang Branch of Chemistry and Chemical Engineering Guangdong Laboratory, Jieyang 515200, Guangdong, China; Synergy Innovation Institute of GDUT, Shantou 515041, China. Electronic address: yangyan1209@gdut.edu.cn. Laboratory Department, Jingmen No. 1 People's Hospital, Jingmen, Hubei 448000, P.R. China College of Life Science and Technology, Beijing University of Chemical Technology, No.15 North Third Ring East Road, Beijing 100029, China State Key Laboratory of Oral Diseases, West China College of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China Department of Cell Biology; Guangdong Province Key Laboratory of Bioengineering Medicine; Jinan University; Guangzhou 510632; China State Key Laboratory of Transducer Technology, Aerospace Information Research Institute, Chinese Academy of Sciences, Beijing 100190, China; School of Electronic, Electrical and Communication Engineering, University of Chinese Academy of Sciences, Beijing 100049, China Department of Environmental Science and Engineering, Nankai University, Tianjin, 300071, P.R. China, and School of Sustainable Engineering and the Built Environment and the School of Sustainability, Arizona State University, Tempe, Arizona 85287 Department of Gastroenterology, Sir Run Run Hospital, Nanjing Medical University, Nanjing, Jiangsu, China Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration, Ministry of Education, Tongji Hospital, the Institute for Biomedical Engineering & Nano Science, School of Medicine, Tongji University, Shanghai 200092, China State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Key Laboratory of Polymorphic Drugs of Beijing, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China Department of Geriatric Medicine Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China Prenatal Diagnosis Center West China Second University Hospital, Sichuan University Chengdu China College of Life Sciences, Wuhan University, Wuhan 430072, China;; Wuhan Institute of Virology, State Key Laboratory of Virology, Chinese Academy of Sciences, Wuhan 430071, China; and Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China State Key Laboratory of Protein and Plant Gene Research Peking‐Tsinghua Center for Life Sciences College of Life Sciences Peking University Beijing 100871 China Columbus Children's Research Institute and The Ohio State University Columbus Ohio Drug Discovery Department, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612 Department of Physical and Chemical Analysis, Fujian Center for Disease Control and Prevention, Fuzhou, China MOE Key Laboratory of Marine Genetics and Breeding, College of Marine Life Sciences, Ocean University of China, Qingdao 266003, China 3Dalton Cardiovascular Research Center, University of Missouri-Columbia, Columbia, MO 65211 Department of Head and Neck Surgery Sichuan Cancer Hospital & Institute Sichuan Cancer Center School of Medicine University of Electronic Science and Technology of China Chengdu China Department of Oral and Maxillofacial Surgery, Nanjing Stomatological Hospital Medical School of Nanjing University Nanjing China Department of Pathology and Pathophysiology, School of Basic Medicine and Biological Sciences Soochow University Suzhou China College of Communication Engineering (College of Microelectronics), Chengdu University of Information Technology, Chengdu 610225, China Guangdong Provincial Key Laboratory of Food, Nutrition, and Health; Department of Nutrition, and State Key Laboratory of Biotherapy and Cancer Center/National Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China Shanghai Tenth People’s Hospital, The Institute for Biomedical Engineering & Nano Science Tongji University School of Medicine Shanghai 200092 P. R. China; Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education, Orthopaedic Department of Tongji Hospital Tongji University School of Medicine 389 Xincun Road Shanghai 200065 P. R. China Nursing Department, Renji Hospital School of Medicine, Shanghai Jiao Tong University Shanghai China First Affiliated Hospital of Jilin University, Changchun, Jilin Province, China. Collaborative Innovation Center for Vessel Pollution Monitoring and Control, Dalian Maritime University, Dalian 116026, China State Key Laboratory of Precision Spectroscopy; East China Normal University; Shanghai 200062; China Department of Anesthesiology, Ruijin Maternal and Child Health Hospital, Ruijin, Jiangxi, 342500, China Department of Nephrology, The First People's Hospital of Changzhou The Third Affiliated Hospital of Soochow University Changzhou China College of Fisheries and Life Science Shanghai Ocean University Shanghai China; Quality and Standards Research Center Chinese Academy of Fishery Sciences Beijing China; Key Laboratory of Aquatic Product Quality and Safety Control Ministry of Agriculture Beijing China Department of Hematology Department of Respiratory and Critical Care Medicine, Sichuan Academy of Medical Sciences& Sichuan Provincial People's Hospital, Chengdu 610072, China. Institute of natural resources and conservation lands, Hunan Academy of Forestry Experimental Medicine Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1095 Jiefang Avenue, Wuhan 430030, China Graduate School of the Chinese Academy of Sciences, Beijing 100049, China Ningbo Academy of Inspection and Quarantine, Ningbo, China School of Chemistry and Chemical Engineering, Nanjing University of Science and Technology, Nanjing, Jiangsu 210094, PR China Department of Cell Biology, College of Life Science and Technology, Jinan University, Guangzhou, People's Republic of China. School of Life Sciences; Jilin University; Changchun P. R. China State Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences , Harbin, China College of Life and Environmental Sciences, Shanghai Normal University, Shanghai 200234, China Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi, China Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China Department of Chemistry, Brown University, Providence, Rhode Island 02912, United States The Research Institute at Nationwide Children's Hospital and The Ohio State University Columbus Southeast University School of Instrument Science and Engineering, , Nanjing 210096, China and Key Laboratory of Micro-inertial Instrument and Advanced Navigation Technology, , Nanjing 210096, China; Ministry of Education School of Instrument Science and Engineering, , Nanjing 210096, China and Key Laboratory of Micro-inertial Instrument and Advanced Navigation Technology, , Nanjing 210096, China Institute of Nephrology, Zhong Da Hospital, Southeast University School of Medicine, Nanjing, China School of Medicine and Life Sciences, Nanjing University of Chinese Medicine, 138 Xianlin Rd, Nanjing, Jiangsu 210023, China; Key Laboratory of Chinese Medicine for Prevention and Treatment of Neurological Diseases, Nanjing University of Chinese Medicine, 138 Xianlin Rd, Nanjing, Jiangsu 210023, China; State Key Laboratory Cultivation Base for TCM Quality and Efficacy, Nanjing University of Chinese Medicine, Nanjing 210023, China; Key Laboratory of Drug Target and Drug for Degenerative Disease of Jiangsu Province, Nanjing University of Chinese Medicine, Nanjing 210023, China; Jiangsu Key Laboratory for Functional Substance of Chinese Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China Department of Stomatology, People’s Hospital of Bayinguleng Mongolian Autonomous Prefecture, Kuerla, Xinjiang 841000, China Department of Endocrinology, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan China School of Life Science Jilin University Changchun PR China Key Laboratory of Nonferrous Metal Chemistry, and Resources Utilization Gansu Province School of Chemistry, and Chemical Engineering Lanzhou University Lanzhou 730000 P.R. China Shaanxi Key Laboratory of CSCIIP, Xi'an University of Technology, Xi'an 710048, People's Republic of China Institute of Edible Fungi, Shanghai Academy of Agricultural Sciences, Shanghai, P.R. China Department of Clinical Laboratory, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou 563003, P.R. China Department of Neurology The Third Xiangya Hospital of Central South University Changsha Hunan China National Engineering Research Center of Solid-State Manufacturing, Luzhou 646000, China. School of Life Sciences, Ningxia University, Yinchuan 750021, China Yangzhou University School of Horticulture and Plant Protection, , Yangzhou, 225009, Jiangsu Province, China Department of Radiotherapy, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province - China College of Horticulture, Gansu Agricultural University, Yingmen Village, Anning District, Lanzhou 730070, China Department of Pathophysiology, School of Basic Medical Sciences Harbin Medical University Harbin China Department of Geriatric MedicineHuazhong University of Science and Technology Wuhan China East China Normal University State Key Laboratory of Precision Spectroscopy, Department of Physics, , Shanghai 200062, People's Republic of China The Fourth Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu, People's Republic of China Department of Nephrology, The First Affiliated Hospital, Sun Yat-Sen University, Key Laboratory of Nephrology, Ministry of Health of China, Guangdong Provincial Key Laboratory of Nephrology, Guangzhou, China Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520 *Center for Molecular and Human Genetics, Columbus Children’s Research Institute, Columbus, OH 43205; and Affiliated Hospital Jiangnan University, No.1000, He Feng Road, Wuxi, Jiangsu Province, 214122, China Department of Endocrinology Chinese PLA General Hospital Beijing China Department of Dermatology, Third Xiangya Hospital, Central South University, Changsha 410013, Hunan, China Institute of Edible Fungi, Shanghai Academy of Agricultural Sciences, Shanghai 201403, China 2State Key Laboratory of Brain and Cognitive Sciences, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China; 4University of Chinese Academy of Sciences, Beijing, China Linyi Academy of Agricultural Sciences Linyi China Key Laboratory of Medical Electrophysiology of Ministry of Education, Collaborative Innovation Center for Prevention and Treatment of Cardiovascular Disease, Institute of Cardiovascular Research, Southwest Medical University, Luzhou 646000, China. wyangyan@wsmu.edu.cn. Department of Integrated Chinese and Western Medicine, Jilin Tumor Hospital, Changchun 130012, China. yangyanjl@126.com Department of Radiology, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, China Department of Medical Oncology, The First Affiliated Hospital of Bengbu Medical College, Bengbu, China. College of Life Science Jilin University Qianjin Street Changchun 130012 People's Republic of China; National Engineering Laboratory for AIDS Vaccine Jilin University Changchun Jilin Province P.R. China; Key Laboratory for Molecular Enzymology and Engineering, the Ministry of Education Jilin University Changchun Jilin Province P.R. China United Faculty of Agriculture, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan College of Chemistry and Chemical Engineering; Liaocheng University; Liaocheng 252059; China Department of General Practice, Gongyi People’s Hospital, No. 117 Renmin Road, Gongyi 451200, China Department of Hypertension, Ruijin Hospital and Shanghai Institute of Hypertension, Shanghai JiaoTong University School of Medicine, Shanghai 200025, China Beijing Children's Hospital Affiliated to Capital University of Medical Sciences, Beijing. yy2303@sina.com Department of Psychological Sciences Swinburne University of Technology Hawthorn Victoria Australia Department of Haematology and OncologyThe First Hospital, Jilin University, Changchun, China Department of Kinesiology and Community Health, College of Applied Health Sciences, University of Illinois at Urbana-Champaign, Champaign, Illinois School of Public Health (Shenzhen), Sun Yat-Sen University, Guangzhou, China; Guangdong Engineering Technology Center of Nutrition Transformation, Guangzhou, China Department of Oncology, The Affiliated Jiangning Hospital with Nanjing Medical School, Nanjing 211100, China School of Medicine & Holistic Integrative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China Department of Physiology, Zhejiang Chinese Medical University Hebei Key Laboratory of Chinese Medicine Research on Cardio‐Cerebrovascular Disease Pharmaceutical College, Hebei University of Chinese Medicine Shijiazhuang City Hebei Province China School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China National Laboratory for Infrared Physics, Shanghai Institute of Technical Physics, Chinese Academy of Sciences, Shanghai 200083, China; University of Chinese Academy of Science, Beijing 100049, China; College of Materials and Environmental Engineering, Hangzhou Dianzi University, Hangzhou, Zhejiang 310018, China Nanjing Hydraulic Research Institute, Nanjing 211100, China; Desalination and Alternative Water Development & Utilization Research Center, Hohai University, Nanjing 211100, China Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University Hubei, Wuhan 430079, P. R. China School of Chinese-Western Medicine Integration, Southwest Medical University Luzhou 646000, China Department of Hepatology,the Fifth Medical Center of Chinese PLA General Hospital Beijing 100039, China. East China Normal University Department of Physics and State Key Laboratory of Precision Spectroscopy, , 200062 Shanghai, People’s Republic of China Institute of Dermatology Guangzhou Medical University Guangzhou China; Department of Dermatology Guangzhou Institute of Dermatology Guangzhou China Department of Cell Biology & Guangdong Provincial Key Laboratory of Bioengineering Medicine Jinan University Guangzhou China; Guangdong Provincial Biotechnology Drug & Engineering Technology Research Center Guangzhou China Institute of Nephrology, Zhongda Hospital, Southeast University School of Medicine, Nanjing, Jiangsu, China. Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration Ministry of Education Tongji Hospital School of Medicine Tongji University 389 Xincun Road Shanghai 200065 China Department of Radiology, Xinqiao Hospital, Third Military Medical University Department of Prosthodontics, West China School of Stomatology, Sichuan University, Chengdu 610041, China. Henan Institute of Occupational Health, Zhengzhou 450052, China. Department of Biological Chemistry, College of Basic Medical Sciences, Dalian Medical University, Dalian, Liaoning 116044, P.R. China Key Laboratory of Medical Electrophysiology of Ministry of Education and Medical Electrophysiological Key Lab of Sichuan Province, Collaborative Innovation Center for Prevention and Treatment of Cardiovascular Disease, Institute of Cardiovascular Research, Southwest Medical University, Luzhou, China Shanghai Skin Disease Hospital School of Medicine Tongji University Shanghai 200092 P. R. China Department of Stomatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430074, P. R. China *College of Basic Medical Sciences, Dalian Medical University, Liaoning 116044, China; State Key Laboratory of Inorganic Synthesis and Preparative Chemistry Jilin University 2699 Qianjin Street Changchun 130012 China Department of General Surgery, Hebei Key Laboratory of Colorectal Cancer Precision Diagnosis and Treatment, the First Hospital of Hebei Medical University, Shijiazhuang, China State Key Laboratory of Crop Gene Exploration and Utilization in Southwest China, Key Laboratory of Biology and Genetic Improvement of Maize in Southwest Region of Ministry of Agriculture, Maize Research Institute, Sichuan Agricultural University, Chengdu 611130, China Institute of Nephrology, Zhongda Hospital Southeast University School of Medicine Nanjing Jiangsu China School of Chemistry and Chemical Engineering, Guangxi University, Nanning, Guangxi, China Guangdong Provincial Key Laboratory of Advanced Energy Storage Mater. School of Materials Science and Engineering South China University of Technology Guangzhou 510641 China Jiangsu Key Laboratory of Advanced Laser Materials and Devices, School of Physics and Electronic Engineering, Jiangsu Normal University, Xuzhou, Jiangsu 221116, China Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education & Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College College of Energy, Chengdu University of Technology, Chengdu 610059, Sichuan, People's Republic of China Yan Yang is a research economist in the Research Institute, Palo Alto Medical Foundation. Department of Pathology Beijing Friendship Hospital Capital Medical University Beijing China Division of Endocrinology Tongji Hospital Huazhong University of Science & Technology Wuhan China Department of Endocrinology and Inherited Metabolic Diseases, Children’s Hospital of Fudan University, Shanghai 201102, China Clinical Laboratory, South Region of Jingmen No. 1 People's Hospital, Jingmen, Hubei 448000, P.R. China School of Food and Biological Engineering, Shaanxi University of Science and Technology, Xi’an 710021, China aDepartment of Pathology, Wayne State University School of Medicine, Detroit, Michigan 48201 From the Molecular Cardiology Research Institute, Tufts Medical Center, and Sackler School of Biomedical Graduate Studies, Tufts University School of Medicine, Boston, MA (K.B.M., M.A., I.Z.J.); Research Service, Harry S. Truman Memorial Veterans’ Hospital, Columbia, MO (S.B.B.); Department of Biomedical Sciences (S.B.B.), Dalton Cardiovascular Research Center (S.B.B., K.H., Y.Y., M.A.H.), and Department of Medical Pharmacology and Physiology, School of Medicine (K.H., M.A.H.), University of... Heilongjiang University of Chinese Medicine, Harbin, China Department of Oncology, Nanjing Jiangning Hospital, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing, China Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals, Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, Henan, 453007, P. R. China College of Marine Life Sciences Ocean University of China Yushan Road 5 Qingdao 266003 People's Republic of China School of Pharmacy Lanzhou University Lanzhou 730000 People's Republic of China School of Chemistry and Chemical Engineering, Guangxi University, Nanning 530004, P. R. China State Key Laboratory of Polymer Materials Engineering, College of Polymer Science and Engineering, Sichuan University, Chengdu 610065, China School of Public Health, Guangxi Medical University, Nanning, China.; Yulin Center for Disease Control and Prevention, Yulin, China. Department of Pathology, Beijing Friendship Hospital Capital Medical University Beijing People's Republic of China Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education of PRC, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China. State Key Laboratory of Crop Stress Biology for Arid Areas, College of Agronomy, Northwest A&F University, Xianyang 712100, China College of Life Science Jiangxi Normal University Nanchang 330022 P. R. China Kunming Institute of Environmental Science Kunming Yunnan China Shanghai Health Development Research Center, Shanghai, China. Key Laboratory of Edible Fungi Resources and Utilization (South) of Ministry of Agriculture Shanghai China; National Engineering Research Center of Edible Fungi Key Laboratory of Agricultural Genetics and Breeding of Shanghai Shanghai China; Institute of Edible Fungi Shanghai Academy of Agricultural Sciences Shanghai China Jiangsu Key Laboratory of Oral Diseases Nanjing Medical University 140 Hanzhong Road Nanjing Jiangsu 210029 China; Department of Orthodontics The Affiliated Stomatological Hospital of Nanjing Medical University 136 Hanzhong Road Nanjing Jiangsu 210029 China A.A. Martinos Center for Biomedical Imaging Massachusetts General Hospital, Harvard Medical School 149 13th Street, Suite 2301 Charlestown MA 02129 USA; Zhongnan Hospital of Wuhan University Donghu Road 169 Wuhan Hubei Province China State Key Laboratory of Catalysis and Molecular Reaction Dynamics, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian 116023, P. R. China Department of Clinical Laboratory, Shanghai Putuo People's Hospital, Tongji University, Shanghai, China Department of Endocrinology, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu, Sichuan, China. Department of Ophthalmology, The Second Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210017, China Department of Health Policy Research, Shanghai Health Development Research Center, Shanghai Medical Information Center Laboratorie de Physique et Chimie des Nano-objects; Institute National Des Sciences Appliquees; Toulouse 31077; France Department of General Medicine, Bingma Township Central Health Center, Baoshan, China. Key Laboratory of the Three Gorges Reservoir Region’s Eco-Environment, Ministry of Education, College of Environment and Ecology, Chongqing University, Chongqing 400045, PR China; Department of Civil and Environmental Engineering and Earth Sciences, University of Notre Dame, Notre Dame, Indiana 46556, United States Department of Hematology, Chinese PLA General Hospital , Beijing 100853, China. Institute of Microelectronics Chinese Academy of Sciences Beijing 100029 China Department of Medical Oncology, First Affiliated Hospital of Bengbu Medical College, Bengbu 233004, China. National Center for Chronic and Noncommunicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 100050, China. Department of General Surgery , 920th Hospital of Joint Logistics Support Force, PLA , Kunming , China Department of Hepatobiliary Pancreatic Surgery,Affiliated Hospital of Hainan Medical University,Haikou,Hainan,China Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX;; Immunology Program, Graduate School of Biomedical Science, University of Texas Health Science Center at Houston, Houston, TX; and State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China; University of Chinese Academy of Sciences, Beijing, China School of Materials Science and Engineering Guangdong Provincial Key Laboratory of Advanced Energy Storage Materials South China University of Technology Guangzhou 510641 P. R. China School of Pharmacy, Anhui Medical University, Meishan Road, Hefei, Anhui Province 230032, China.; Institute for Liver Disease of Anhui Medical University, Meishan Road, Hefei, Anhui Province 230032, China. State Key Laboratory of Precision Spectroscopy and Department of Physics, East China Normal University, Shanghai 200062, P. R. China Institute for Computational and Mathematical Engineering, Stanford University, Stanford, California 94305 State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China; Key Laboratory of Biosynthesis of Natural Products of National Health Commission of the Peoplés Republic of China, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals, Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, Henan 453007, P.R. China Department of Dermatology, Guangzhou Institute of Dermatology, Guangzhou, Guangdong, China Shaanxi Key Laboratory of Chemical Additives for Industry College of Chemistry and Chemical Engineering Shaanxi University of Science and Technology Xi'an 710021 P. R. China Key Laboratory of CNS Regeneration (Ministry of Education), Guangdong-Hong Kong-Macau Institute of CNS Regeneration, Jinan University, Guangzhou, China. State Key Laboratory of Crop Stress Biology for Arid Areas, College of Agronomy, Northwest A&F University, Yangling 712100, China National Clinical Research Center for Infectious Diseases, The Second Affiliated Hospital School of Medicine, Southern University of Science and Technology; Shenzhen Third People’s Hospital, Shenzhen, People’s Republic of China State Key Laboratory of Water Environment Simulation, School of Environment, Beijing Normal University, Beijing 100875, China From the Key Lab of Medical Electrophysiology of Ministry of Education and Medical Electrophysiological Key Lab of Sichuan Province, Institute of Cardiovascular Research, Southwest Medical University, Luzhou, China (J.C., J.W., N.W., Q.X., Y.Y.) College of Chemistry and Chemical Engineering, Liaocheng University, Liaocheng 252059, China Department of Kinesiology and Community Health, University of Illinois, Champaign, IL, USA Jin Li, Fudan University Shanghai Cancer Center; Liwei Wang, Shanghai First People’s Hospital; Leizhen Zheng, XinHua Hospital Affiliated to Shanghai Jiaotong University, Shanghai; Shukui Qin, People’s Liberation Army (PLA) Cancer Center, 81st Hospital of PLA; Zhining Fan, Second Affiliated Hospital of Nanjing Medical University; Hao Yu, Nanjing Medical University, Nanjing; Jianming Xu, 307th Hospital of PLA, Academy of Military Medical Sciences; Honggang Zhang, Chinese Academy of Medical Sciences Cancer... College of Life Sciences, Modern Virology Center, Wuhan University, Wuhan 430072, China Department of Neurology, Affiliated Hospital of Jining Medical University, Jining, People's Republic of China Institute for Computational and Mathematical Engineering Stanford University Stanford CA 94305 Department of Ophthalmology, The Second Xiangya Hospital of Central South University, Changsha 410011, China; Hunan Clinical Research Center of Ophthalmic Disease, The Second Xiangya Hospital of Central South University, Changsha 410011, China; National Clinical Research Center for Metabolic Diseases, The Second Xiangya Hospital of Central South University, Changsha 410011, China Center for Neuroscience, Key Laboratory of Medical Neurobiology of the Ministry of Health of China, School of Medicine, Interdisciplinary Institute of Neuroscience and Technology, Qiushi Academy for Advanced Studies; Mental Health Center, School of Medicine, Zhejiang University, Hangzhou, China School of Materials Science and Engineering Chongqing University of Technology Chongqing 400054 China Shaanxi Key Laboratory of Chemical Additives for Industry, College of Chemistry and Chemical Engineering, Shaanxi University of Science and Technology, Xi’an 710021, China Center for Tissue Engineering and Stem Cell Research, Guizhou Medical University, Guiyang, China. National Key Laboratory of Helicopter Aeromechanics, College of Aerospace Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing 210016, China College of Mechanical Engineering, Chongqing University of Technology, Chongqing 400054, China Heilongjiang Provincial Key Laboratory of CO2 Resource Utilization and Energy Catalytic Materials, School of Material Science and Chemical Engineering, Harbin University of Science and Technology, Harbin, Heilongjiang 150080, China Department of Diabetes The Second Hospital of Lanzhou University Lanzhou Gansu 730030 China; Department of Endocrinology West China Hospital of Sichuan University Chengdu Sichuan 610041 China Department of Ultrasound, The Second Affiliated Hospital and Yuying Children’ s Hospital of Wenzhou Medical University, Wenzhou 325027, China Laboratory of Pharmacology and Toxicology, School of Pharmaceutical Sciences Sun Yat‐sen University Guangzhou China †Wuhan Institute of Virology, State Key Laboratory of Virology, Chinese Academy of Sciences, Wuhan 430071, China Department of Medical Record, Gansu Provincial Hospital, Lanzhou, People's Republic of China. College of Life Science Jilin University Changchun PR China Central Laboratory of Stomatology, Nanjing Stomatological Hospital Medical School of Nanjing University Nanjing China The Second Military Medical University Shanghai China School of Pharmaceutical Science and Technology, Tianjin University, Tianjin, P. R. China. Division of Epidemiology and Biostatistics, School of Public Health and Management, Wenzhou Medical University, Wenzhou, Zhejiang, China College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China. Wuhan Huake Reproductive Hospital Wuhan China Department of Cell Biology & Guangdong Provincial Key Laboratory of Bioengineering Medicine Jinan University Guangzhou China; Department of Cell Biology National Engineering Research Center of Genetic Medicine, Jinan University Guangzhou China; Biopharmaceutical Research & Development Center Jinan University Guangzhou China Department of Chemistry and Chemical Biology; Cornell University; Ithaca; USA Key Laboratory of Chemical Additives for China National Light Industry, College of Chemistry and Chemical Engineering, Shaanxi University of Science and Technology, Xi’an 710021, China Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Department of Nutrition, School of Public Health, Sun Yat-sen University, Guangzhou, Guangdong, China State Key Laboratory of Catalysis; Dalian Institute of Chemical Physics; Chinese Academy of Sciences; Dalian 116023; China Université de Toulouse et CNRS INSA; UPS; CNRS; UMR 5215; LPCNO Health Management Center, QiLu Hospital of Shandong University Authors' Affiliations: Departments of 1Melanoma Medical Oncology and 2Experimental Diagnostic Imaging, The Center for Cancer Immunology Research, The University of Texas M. D. Anderson Cancer Center, Houston, Texas Department of Chemistry and Biochemistry, New Mexico State University, New Mexico 88003 College of Life Sciences, Shaanxi Normal University, Xi’an, China and Department of Chemistry, Southern Methodist University, Dallas, Texas 75275, State Engineering Laboratory for Industrial Enzymes, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, China, and China Research Center, Genencor, A Danisco Division, Shanghai 200335, China Medical School, Kunming University of Science and Technology, Kunming, China; Department of Gastroenterology, The Third Xiangya Hospital, Central South University, Changsha 410013, China; Hunan Key Laboratory of Non Resolving Inflammation and Cancer, Changsha 410008, China State Key Laboratory of Elemento-Organic Chemistry, College of Chemistry, Frontiers Science Center for New Organic Matter, Nankai University, Tianjin 300071, People’s Republic of China; College of Biomedical Engineering, Taiyuan University of Technology, Taiyuan 030024, People’s Republic of China Institute of Natural Resources and Conservation Lands, Hunan Academy of Forestry, Changsha, Hunan, China. , , , Shanghai Jiao Tong University, , China Guangzhou Women and Children’s Medical Center, Guangzhou, China State Key Laboratory of Water Environment Simulation, School of Environment Beijing Normal University Beijing China School of Science, China Pharmaceutical University, Nanjing, Jiangsu, China; National Center for Chronic and Noncommunicable Disease Control and Prevention, Beijing 100050, China. Departments of Biochemistry and Biophysics and Pathology, University of Rochester, Rochester, NY 14642 Department of Nutrition School of Public Health Sun Yat‐sen University Guangzhou PR China; Guangdong Provincial Key Laboratory of Food Nutrition and Health Guangzhou PR China; School of Public Health (Shenzhen) Sun Yat‐sen University Guangzhou PR China College of Life Sciences, Beijing Normal University, Beijing, People's Republic of China; Wuhu TianJiaBing Experimental High School, Wuhu, People's Republic of China National Laboratory for Infrared Physics, Shanghai Institute of Technical Physics, Chinese Academy of Sciences, Shanghai 200083, China Department of Medical Oncology, The First Affiliated Hospital of Bengbu Medical College Bengbu, Anhui, China. Department of Radiation Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, P.R. China The Jackson Laboratory, Bar Harbor, Maine, USA. Shanghai, China. Division of Endocrinology, Tongji Hospital, Huazhong University of Science & Technology, Wuhan, PR China; Branch of national clinical research center for metabolic diseases, Hubei, PR China Beijing Laboratory of Biomedical Materials The State Key Laboratory of Organic–Inorganic Composites Beijing Advanced Innovation Center for Soft Matter Science and Engineering College of Life Science and Technology Beijing University of Chemical Technology Beijing 100029 P. R. China College of Marine Life Sciences, Ocean University of China, Qingdao 266003, P. R. China Department of Stomatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P. R. China State Key Laboratory of Precision Spectroscopy, East China Normal University, 3663 North Zhongshan Road, Shanghai 200062, China Drug Discovery Department H. Lee Moffitt Cancer Center & Research Institute Tampa FL USA State Key Laboratory of Microbial Metabolism, School of Life Science and Biotechnology, Shanghai Jiao Tong University, Shanghai, People’s Republic of China Department of Ophthalmology, the Second Xiangya Hospital of Central South University, Changsha, People’s Republic of China Department of Physics, National Laboratory of Solid State Microstructure, Nanjing University, Nanjing 210093, China School of the Information Engineering; Nanchang Hangkong University; Nanchang 330063; P. R. China Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Department of Nutrition, School of Public Health, Sun Yat-sen University, No. 74 Zhongshan Road 2, Guangzhou, Guangdong 510080, China Department of Clinical Laboratory, The Affiliated Lianyungang Hospital of Xuzhou Medical University, The First People’s Hospital of Lianyungang, Haizhou District, Lianyungang, China Department of Emergency Medicine, Sun Yat-sen University/The First Affiliated Hospital, Guangzhou 510080, China; NHC Key Laboratory of Assisted Circulation (Sun Yat-sen University), Guangzhou 510080, China Key Laboratory of Biology and Genetic Improvement of Maize in Southwest Region Maize Research Institute Sichuan Agricultural University Chengdu China Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiaotong University Reproductive Center, Shanghai, China Urumqi Fourth People's Hospital, Urumqi, China. The Laboratory for Biomechanics of Animal Locomotion, Graduate University of Chinese Academy of Sciences, Beijing 100049, China; Department of Modern Mechanics, University of Science and Technology of China, Hefei 230026, China Department of Laboratory Medicine, Affiliated Hospital of Zunyi Medical University, Guizhou, China The Shaanxi Key Laboratory of Clothing Intelligence, School of Computer Science, Xi’an Polytechnic University , Xi’an 710048, China Process Development Downstream, Shanghai Engineering Research Center of Anti‐tumor Biological Drugs Shanghai Henlius Biotech, Inc. Shanghai China Department of Breast and Thyroid Surgery, Suining Central Hospital, Suining, Sichuan Province, China. Faculty of Food Science and Technology, Yunnan Agricultural University, Kunming 650201, China. chrisyy1016@yahoo.com.cn College of Materials and Environmental Engineering; Hangzhou Dianzi University; Hangzhou; P.R. China Tropical Crops Genetic Resources Institute, Chinese Academy of Tropical Agricultural Sciences, Key Laboratory of Crop Gene Resources and Germplasm Enhancement in Southern China, Ministry of Agriculture and Rual Affairs, Key Laboratory of Tropical Crops Germplasm Resources Genetic Improvement and Innovation of Hainan Province, No. 4 Xueyuan Road, Longhua, Haikou 571101, China State Key Laboratory of Biogeology and Environmental Geology, China University of Geosciences, Wuhan, 430074, P. R. China; Civil Engineering College, Guizhou University, Guiyang, 550025, P. R. China Department of Nephrology, The First People's Hospital of Changzhou, Changzhou, Jiangsu 213003, China Key Laboratory of Chemical Additives for China National Light Industry College of Chemistry and Chemical Engineering Shaanxi University of Science and Technology Xi'an 710021 P. R. China Guangxi Key Lab of Agricultural Resources Chemistry and Biotechnology, College of Chemistry and Food Science, Yulin Normal University, 1303 Jiaoyudong Road, Yulin 537000, P. R. China; School of Chemistry and Chemical Engineering, Guangxi University, 100 Daxuedong Road, Nanning 530004, P. R. China Guangdong Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, P. R. China Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Hubei, Wuhan 430079, P. R. China Department of Pharmacology School of Basic Medical Sciences Anhui Medical University Key Laboratory of Anti‐Inflammatory and Immunopharmacology, Ministry of Education Hefei China Institute of Edible Fungi, Shanghai Academy of Agricultural Sciences, Shanghai 201106, P.R. China State Key Laboratory for Plant Diseases and Insect Pests Institute of Plant Protection Chinese Academy of Agricultural Sciences Beijing China College of Biotechnology, Tianjin University of Science and Technology, Tianjin 300457, China; Key Laboratory of Industrial Fermentation Microbiology, Ministry of Education, Tianjin University of Science and Technology, Tianjin 300457, China Beijing Laboratory of Biomedical Materials, The State Key Laboratory of Organic−Inorganic Composites, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China Department of Ophthalmology, the First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Ophthalmology, Chongqing Eye Institute, Chongqing, China Engineering Research Center for Nanomaterials, Henan University, Kaifeng 475004, China Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization Gansu Province School of Chemistry and Chemical Engineering Lanzhou University Lanzhou 730000 P.R. China Department of Otolaryngology, Shanghai Punan Hospital, Shanghai, 200125. Institute of Biochemistry and Molecular Biology; School of Life Sciences; Lanzhou University; Lanzhou 730000; China The Fourth People’s Hospital of Zhenjiang, Prenatal diagnosis center, Zhenjiang, Jiangsu 212000, China Department of General Surgery, Hebei Key Laboratory of Colorectal Cancer Precision Diagnosis and Treatment; Department of Vascular Surgery; Department of General Surgery, the First Hospital of Hebei Medical University, Hebei, Shijiazhuang, China. Department of Kidney Diseases, Southwest Hospital, Army medical university, Chongqing 400038, China. Liaoning Medical Instrument Inspection and Testing Institute. Institute of Edible Fungi Shanghai Academy of Agricultural Sciences Shanghai People's Republic of China; Key Laboratory of Edible Fungi Resources and Utilization (South) Ministry of Agriculture Shanghai People's Republic of China School of Mathematics and Statistics, Institute for Information and System Sciences, Xi’an Jiaotong University, Xi’an, China National Laboratory for Infrared Physics, Shanghai Institute of Technical Physics, Chinese Academy of Sciences, Shanghai 200083, China; University of Chinese Academy of Sciences, Beijing 100049, China From The First Affiliated Hospital of Chongqing Medical University, Youyi Road 1, Chongqing Key Laboratory of Ophthalmology, and Chongqing Eye Institute, Chongqing, People's Republic of China; and the From the State Key Laboratory of Cancer Biology, Xijing Hospital of Digestive Diseases (Drs Shang, Chai, Zhou, Ren, Fan, Wu, and Nie and Mr Gu, Mss Ding and Yang), and the Department of Medical Laboratory, Xijing Hospital (Dr Hao and Ms Ding), Fourth Military Medical University, and the Department of Digestive Diseases, Shaanxi Provincial Corps Hospital of Chinese People's Armed Police Force (Mr Gu), Xi'an, China. Drs Shang, Chai, and Mr Gu contributed equally to this article. Department of Internal Medicine, Tianjin Hospital, Tianjin, China Department of Clinical Laboratory, Jingmen No. 1 People’s Hospital, Jingmen, Hubei, China (mainland) Sichuan University, China Renji Hospital affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China; Second Military Medical University, Shanghai, China Institute of Nephrology, Zhong Da Hospital, Southeast University School of Medicine, Nanjing UNC Center for AIDS Research, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA; Division of Infectious Diseases, Department of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA Key Laboratory of Theoretical Organic Chemistry and Functional Molecules; Ministry of Education; and School of Chemistry and Chemical Engineering; Hunan University of Science and Technology; Xiangtan 411201; China Department of Otorhinolaryngology the First People’s Hospital of Yunnan Province Kunming China Center for Biophysics and Computational Biology, University of Illinois at Urbana−Champaign, 607 South Mathews Avenue, Urbana, Illinois 61801, W. M. Keck Center for Comparative and Functional Genomics, University of Illinois at Urbana−Champaign, 1201 West Gregory Drive, Urbana, Illinois 61801, Department of Statistics, University of Illinois at Urbana−Champaign, 725 South Wright Street, Champaign, Illinois 61820, School of Molecular and Cellular Biology, University of Illinois at Urbana−Champaign, 505... Department of Oncology, Hospital Affiliated 5 to Nantong University (Taizhou People’s Hospital), Taizhou, China Business School of Hunan University, Changsha 410082, China Department of Endocrinology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China Department of Hematology, The First Hospital of Jilin University, Changchun, China Center of Reproductive Medicine, Peking University Third Hospital, Beijing 100191, China. Department of Bioengineering; Zhuhai Campus of Zunyi Medical University; Zhuhai; P. R. China Stanford Center for Genomics & Personalized Medicine, Stanford University School of Medicine MOE Key Laboratory of Geriatric Diseases and Immunology School of Biology and Basic Medical Sciences, Suzhou Medical College of Soochow University Suzhou China College of Materials and Environmental Engineering; Hangzhou Dianzi University; Hangzhou 310018; People's Republic of China Department of Reproductive Medicine Center; Shanghai Jiao Tong University Affiliated Sixth People's Hospital; Shanghai China Department of Endocrinology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430000, China National Clinical Research Center for Metabolic Diseases, Metabolic Syndrome Research Center, Key Laboratory of Diabetes Immunology, Ministry of Education and Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University, Changsha 410011, Hunan, China State Key Laboratory of Oral Disease, West China Hospital of Stomatology Sichuan University Chengdu China; National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology Sichuan University Chengdu China; National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology Sichuan University Chengdu China; Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology Sichuan University Chengdu China Department of Nutrition, School of Public Health, Sun Yat-sen University (Northern Campus), Guangzhou, China (H.X., Y.Y., W.L.).; Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Guangzhou, China (H.X., X.C., S.C., Y.Y., W.L.).; School of Public Health (Shenzhen), Sun Yat-sen University, Shenzhen, China (Y.Y.). Authors' Affiliations: Departments of 1Melanoma Medical Oncology and 2Immunology, Center for Cancer Immunology Research; 3Department of Systems Biology, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas; Divisions of 4Surgical Oncology and 5Medical Oncology, Massachusetts General Hospital, Boston, Massachusetts State Key Laboratory of Estuarine and Coastal Research, East China Normal University, Shanghai 200241, China Wallace H. Coulter Department of Biomedical Engineering, Georgia Tech and Emory University, Atlanta, GA 30332, USA. Guangxi Key Lab of Agricultural Resources Chemistry and Biotechnology, College of Chemistry and Food Science, Yulin Normal University, 1303 Jiaoyudong Road, Yulin 537000, PR China; Guangxi Zhuang Yao Medicine Center of Engineering and Technology, Guangxi University of Chinese Medicine, Nanning, Guangxi 530200, P. R. China Kolltan Pharmaceuticals, New Haven, Connecticut. The Key Laboratory of Resource Chemistry of Ministry of Education, Shanghai Key Laboratory of Rare Earth Functional Materials, and Shanghai Municipal Education Committee Key Laboratory of Molecular Imaging Probes and Sensors, Shanghai Normal University, Shanghai, China Department of Polymer Science & Engineering and Key Laboratory of Mesoscopic Chemistry of MOE, School of Chemistry & Chemical Engineering, Nanjing University, Nanjing 210093, China Baoshan Hospital affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201999, China; Baoshan District Hospital of Integrated Traditional Chinese and Western Medicine of Shanghai, Shanghai 201999, China Department of Chinese Medicine, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, China Department of Geriatric Endocrinology, Chinese PLA General Hospital, Beijing 100853, China. Howard Hughes Medical Institute, W. M. Keck Foundation Center for Integrative Neuroscience and Department of Physiology, University of California, San Francisco, San Francisco, California Department of EICU, The First Hospital of Jilin University, Changchun City, Jilin 130021, China Institute of Vegetable Crops, Jiangsu Academy of Agricultural Sciences, Nanjing 210014, China; Laboratory for Horticultural Crop Genetic Improvement, Nanjing 210014, China College of Life Science Jilin University Changchun P. R. China School of Materials Science and Engineering Chongqing University of Technology Chongqing 400054 P. R. China Department of Respiratory Medicine Shan Dong Chest Hospital Jinan China College of Marine Life Sciences, Ocean University of China, Qingdao 266100, China Department of Earth and Environment, Boston University, Boston, MA 02215; Kunming Institute of Zoology Chinese Academy of Science Kunming Yunnan 650223 China Linyi Agriculture Science Institute Linyi Shandong China Department of Neurology, The Affiliated Hospital of Jining Medical University, Jining, 272000, China Department of Huiqiao Nanfang Hospital Southern Medical University Guangzhou China Key Laboratory of Soft Chemistry and Functional Materials of Education Ministry, Nanjing University of Science and Technology, Nanjing 210094, China Beijing Key Lab of TCM Collateral Disease Theory Research, School of Traditional Chinese Medicine, Capital Medical University, No. 10 Xitoutiao, Youanmenwai, Fengtai District, Beijing 100069, China The 2nd affiliated Hospital of Chongqing Medical University, Chongqing, China Shanghai Jiao Tong University School of Nursing Shanghai China Department of Rehabilitation Medicine, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Sichuan, China Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06510 State Key Laboratory of Water Environment Simulation, School of Environment, Beijing Normal University, Beijing 100875, P. R. China Shanghai Skin Disease Hospital The Institute for Biomedical Engineering & Nano Science School of Medicine Tongji University Shanghai 200092 China College of Basic Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China Department of Chemical Engineering, Anhui University of Science and Technology Key Laboratory of Medical Electrophysiology of Ministry of Education and Medical Electrophysiological Key Lab of Sichuan Province, Collaborative Innovation Center for Prevention and Treatment of Cardiovascular Disease, Institute of Cardiovascular Research, Southwest Medical University, Luzhou, Sichuan, China; Department of Cardiology, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China College of Marine Life Sciences Ocean University of China, Yushan Road 5 266003 Qingdao P. R. China Department of Radiology; Hubei Province Key Laboratory of Molecular Imaging, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan; Department of Radiology, The Affiliated Hospital of Guizhou Medical University, Guiyang, China Department of Nutrition, School of Public Health, Sun Yat-Sen University, Guangzhou, China; Department of Health Policy Research, Shanghai Health and Development Research Center CNRS, INSA, UPS, UMR 5215, LPCNO, Université de Toulouse, 135 avenue de Rangueil, 31077 Toulouse, France Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China Graduate College Heilongjiang University of Chinese Medicine Harbin China Department of Ultrasonic Diagnosis, The Second Affiliated Hospital and Yuying Children's Hospital Wenzhou Medical University Wenzhou Zhejiang 325000 China Jinan University & TYRAN Cosmetics Innovation Research Institute, Guangzhou 511447, Guangdong, China. Shanghai Pulmonary Hospital Affiliated to Tongji University, Shanghai 200433, China. Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724 (A.M., S.D., Y.Y., T.Z., D.J.); Department of Molecular Biology, University of Wyoming, Laramie, Wyoming 82071 (A.L., X.L., D.E.T., K.E.W., D.H., A.W.S.); and J. Craig Venter Institute, Rockville, Maryland 20850 (A.C.) Gannan Medical University Ganzhou Jiangxi PR China Central Laboratory, Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, Jiangsu 210008, P.R. China College of Life Science, Jilin University, Changchun, 130012, P. R. China; Research Center for Drug Metabolism, Jilin University, Changchun, 130012, P. R. China Department of Geriatric Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, P.R. China Heilongjiang Provincial Key Laboratory of CO2 Resource Utilization and Energy Catalytic Materials School of Material Science and Chemical Engineering Harbin University of Science and Technology No. 52, Xuefu Road Harbin 150040 P. R. China; School of Chemistry and Chemical Engineering Harbin Institute of Technology Harbin 150001 P. R. China State Key Laboratory of Structural Chemistry; Fujian Institute of Research on the Structure of Mater; Chinese Academy of Science; Fuzhou 350002; P. R. China Department of Ultrasound, the Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA. Department of Endocrinology, Tongji Hospital, Tongji Medical College of the Huazhong University of Science and Technology, Wuhan, PR. China School of Mathematical and Statistical Sciences, Arizona State University, Tempe, AZ 85287, USA Laboratory of Molecular Design and Drug Discovery, School of Science China Pharmaceutical University Nanjing China Department of Critical Care Medicine The First People's Hospital of Kunshan Kunshan China School of Ophthalmology & Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China Laboratory of Molecular Design and Drug Discovery, School of Science, China Pharmaceutical University, Nanjing, China; Department of Medical Oncology, the First Affiliated Hospital of Bengbu Medical College, Bengbu 233004, China. College of Life Sciences; Inner Mongolia Agricultural University; 306 Zhaowuda Road Hohhot 010018 Inner Mongolia China Department of Sports Medicine and Joint Surgery/Orthopaedics; First Affiliated Hospital of China Medical University; Shenyang Liaoning 110001 China School of Chemistry and Chemical Engineering, University of South China, No. 28, Changsheng West Road, Hengyang, Hunan 421001, P. R. China College of Control Science and Engineering, China University of Petroleum (East China), Qingdao 266580, China Research Unit for Complementary and Integrative Laser Medicine, Research Unit of Biomedical Engineering in Anesthesia and Intensive Care Medicine, and TCM Research Center Graz, Medical University of Graz, Auenbruggerplatz 39, Graz 8036, Austria; Heilongjiang University of Chinese Medicine, Harbin 150040, China Department of Bioproducts and Biosystems Engineering, University of Minnesota, Saint Paul, MN, USA. Department of Oncology and Hematology, Chongqing Emergency Medical Center, Chongqing University Central Hospital, Chongqing 400014, China Basic Medical College of Heilongjiang University of CM, Harbin 150040, China. School of Materials Science and Engineering, Chongqing University of Technology, Chongqing, 400054 China Department of Respiratory Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang Division of Viral Pathology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China Authors' Affiliations: 1Department of Occupational and Environmental Health and the Ministry of Education Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, and 2Institute of Safety and Environmental Protection, Wuhan Steel & Iron Ltd Co, Wuhan, Hubei, China Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China. Department of Cardiac Surgery, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724 (B.-h.L., R.J., Y.Y., A.G., D.J.); Department of Life Science, Sogang University, Seoul 121–742, Korea (B.-h.L.); University of Amsterdam, Amsterdam, 1098SM, The Netherlands (Y.Y.); Section of Cell and Development Biology, University of California, San Diego, La Jolla, California 92093–0116 (A.G.); Plant Science Center, RIKEN, Tsur Prenatal Diagnosis Center, Jiangxi Women and Children's Health Care Hospital, Nanchang, Jiangxi 330006, China. lyq0914@126.com. Beijing Children's Hospital Affiliated to Capital Medical University, Beijing. Department of Medical Oncology, The First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233004, China School of Life Sciences, Huaibei Normal University, Huaibei, China *Center for Molecular and Human Genetics, Columbus Children’s Research Institute,; †Department of Molecular Virology, Immunology, and Medical Genetics, and; ‡Department of Pediatrics, Ohio State University, Columbus, OH 43205; Department of Medical Oncology, The First Affiliated Hospital of Bengbu Medical College Department of Endocrinology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China State Key Laboratory of Materials Processing and Die Mould Technology; Huazhong University of Science and Technology (HUST); Wuhan 430074; China Laboratory of Molecular Design and Drug Discovery, School of Science, China Pharmaceutical University, 639 Longmian Avenue, Nanjing 211198, China School of Environmental & Safety Engineering, Changzhou University, Changzhou 213164, China. yy129129@163.com Department of Endocrinology, Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, People's Republic of China Vasculocardiology Department, Fuzhou Hospital of Traditional Chinese Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, China Department of Endocrinology (Y.Y.), Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China; Department of Psychiatry and Behavioral Sciences (Y.Y., A.A.M., Z.A.C., T.H.M.), Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 Department of Oncology, The Affiliated Jiangning Hospital with Nanjing Medical University, Nanjing 211100, Jiangsu, China Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853, United States Institute of Cardiology, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Cardio-X Institute, Huazhong University of Science and Technology, Wuhan, China Medical Simulation Center, Nanjing Medical University, Nanjing, China Beijing Aier-Intech Eye Hospital, Beijing 100730, China. Department of Metabolism and Endocrinology, National Clinical Research Center for Metabolic Diseases, Metabolic Syndrome Research Center, Key Laboratory of Diabetes Immunology (Central South University), Ministry of Education The Second Xiangya Hospital of Central South University Changsha China Otorhinolaryngology Head and Neck Surgery The Second Affiliated Hospital of Qiqihar Medical University Qiqihar Heilongjiang China State Key Laboratory of Virology/Institute of Medical Virology, School of Basic Medical Sciences, Wuhan University, Wuhan, Hubei 430071, China Key Laboratory of Theoretical Organic Chemistry and Function Molecule; Ministry of Education; Hunan Provincial Key Laboratory of Controllable Preparation and Functional Application of Fine Polymers; School of Chemistry and Chemical Engineering; Hunan University of Science and Technology Department of Nephrology, The Third Affiliated Hospital of Soochow University, Changzhou, China Fudan University Affiliated Pudong Medical Center, Shanghai 201301, China Beijing National Laboratory for Molecular Sciences (BNLMS), CAS Key Laboratory of Molecular Nanostructure and Nanotechnology, Institute of Chemistry, Chinese Academy of Sciences , Beijing 100190 , China; Research Institute, Zhejiang , Hangzhou 310003 , China; Tiandi Environmental Protection Technology Co. Ltd , Hangzhou 310003 , China; University of Chinese Academy of Sciences , Beijing 100049 , China Department of Pharmacology and Institute of Natural Medicine, Anhui Medical University, Hefei 230032, China Department of Humanistic Nursing School of Nursing Second Military Medical University Shanghai China College of Veterinary Medicine South China Agricultural University Guangzhou China Postgraduate Student, Department of Orthodontics, State Key Laboratory of Oral Diseases, West China School and Hospital of Stomatology, Sichuan University, Chengdu, China. Experimental Medicine Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China Department of Gastroenterology, Xuzhou Central Hospital, Clinical College of Xuzhou Medical College Xuzhou, China. Sichuan Chidingshengtong Biotechnology Co., Ltd., Chengdu, Sichuan, P.R. China Co-Innovation Center for Qinba Regions’ Sustainable Development, College of Life Sciences, Shaanxi Normal University, Xi’an, P.R. China Department of Radiation Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China Department of Neuropathology, University of Heidelberg, Germany; Center for Molecular Biology, University of Heidelberg, Germany Department of Pathology, Wayne State University School of Medicine, Detroit, MI 48201, USA Department of Breast and Thyroid Surgery, Zhongnan Hospital, Hubei Key Laboratory of Tumor Biological Behaviors, Hubei Cancer Clinical Study Center, Wuhan University, Wuhan 430071, Hubei, China Institute of natural resources and conservation lands, Hunan Academy of Forestry, Changsha, Hunan, China. State Key Laboratory of Bioactive Substances and Functions of Natural Medicines Institute of Materia Medica Chinese Academy of Medical Sciences & Peking Union Medical College Beijing China; Department of Pharmacy The Third People's Hospital of Chengdu The Affiliated Hospital of Southwest Jiaotong University The Second Chengdu Hospital Affiliated to Chongqing Medical University Chengdu China Key Laboratory of Veterinary Public Health of Ministry of Agriculture, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China State Key Laboratory of Agricultural Microbiology, College of Life Science and Technology, Huazhong Agricultural University, Wuhan 430070, PR China Department of Child Healthcare, People's Hospital (Children's Hospital) North Hospital, Urumqi, Xinjiang 830011, P.R. China Department of Reproductive Medicine Center, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai 200233, China Jiangsu Collaborative Innovation Center of Photovoltaic Science and Engineering, Changzhou 213164, Jiangsu, China. Department of Chemistry, Southern Methodist University, Dallas, Texas 75275 Shanghai Health Development Research Center (Shanghai Medical Information Center), Shanghai, China. Institute of Agricultural Resources and Environment Shandong Academy of Agricultural Sciences Jinan China Institute of Genomic Medicine, College of Pharmacy, Jinan University Palo Alto Medical Foundation Research Institute Palo Alto California School of Clinical Medicine Department of Obstetrics and Gynecology; West China Second University Hospital; Sichuan University; Chengdu China Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Department of Anesthesiology Laboratory of Anesthesiology and Critical Care Medicine Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei PR China College of Business Administration, Zhejiang University of Technology, Hangzhou, 310023. Molecular Science and Biomedicine Laboratory, State Key Laboratory for Chemo/Bio-Sensing and Chemometrics, College of Material Science and Engineering, College of Chemistry and Chemical Engineering, College of Biology, Hunan University, Changsha, 410082, China State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Biomedical Materials and Engineering Research Center of Hubei Province, Wuhan University of Technology, Wuhan 430070, China Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, School of Life Sciences, Jilin University, Changchun 130012, China Department of International Applied Technology, Yibin University, Yibin 644000, China Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials, School of Chemistry and Materials Science, Jiangsu Normal University, Xuzhou, Jiangsu 221116, P. R. China Department of Neurosurgery The second Affiliated Hospital of XinJiang Medical University Wulumuqi City China Department of Pathophysiology, School of Basic Medical Science Anhui Medical University Hefei Anhui China Clinical Translational Research Center, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai 200433, China; School of Life Science and Technology, Tongji University, Shanghai 200092, China Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration, Ministry of Education, Tongji Hospital, The Institute for Biomedical Engineering & Nano Science, School of Medicine, Tongji University, 200092 Shanghai, P. R. China Sun Yat-sen University, Shenzhen, China Department of Pharmacology, Anhui Medical University, Key Laboratory of Anti‑inflammatory and Immunopharmacology, Chinese Ministry of Education, Hefei, Anhui 230032, P.R. China School of Public Health (Shenzhen) Sun Yat‐sen University Shenzhen Guangdong Province China; Guangdong Provincial Key Laboratory of Food Nutrition and Health Guangzhou Guangdong Province PR China; Guangdong Provincial Engineering Laboratory for Nutrition Translation Guangzhou Guangdong Province PR China CNRS, INSA, UPS, UMR 5215, LPCNO Université de Toulouse 135 avenue de Rangueil 31077 Toulouse France Key Laboratory of Advanced Display Materials and Devices; Ministry of Industry and Information Technology; Institute of Optoelectronics & Nanomaterials; School of Material Science and Engineering; Nanjing University of Science and Technology Department of Pharmacology of Chinese Materia Medica, China Pharmaceutical University, Tong Jia Xiang, Nanjing, China College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, PR China; A.A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, 149 Thirteenth Street, Suite 2301, Charlestown, Massachusetts 02129, United States Key Laboratory of Medical Electrophysiology of Ministry of Education, Collaborative Innovation Center for Prevention and Treatment of Cardiovascular Disease, Institute of Cardiovascular Research, Southwest Medical University, Luzhou, China Department of Microbiology and Immunology, The University of Texas Medical Branch, Galveston, Texas 77555-1019 Department of Obstetric, Jiangjin Maternal and Child Health Hospital , Jiangjin District , Chongqing , 402260 , China Department of Endocrinology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China. College of Marine Sciences, South China Agricultural University, Guangzhou 510642, China Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, Kunming 650031, China; School of Ethnic Medicine, Yunnan Minzu University, Kunming 650031, China School of Medicine and Holistic Integrative Medicine Nanjing University of Chinese Medicine Nanjing China; Key Laboratory for Chinese Medicine of Prevention and Treatment in Neurological Diseases Nanjing University of Chinese Medicine Nanjing China Key Laboratory for Applied Surface and Colloid Chemistry National Ministry of Education Shaanxi Engineering Lab for Advanced Energy Technology School of Materials Science and Engineering Shaanxi Normal University Xi'an 710062 China Department of Stomatology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei Province 430030 China Shanghai Health Development Research Center, Shanghai Medical Information Center, Shanghai, China. Department of Pharmacy Guangzhou General Hospital of Guangzhou Military Command Guangzhou 510010 P. R. China Department of Food Science and Engineering Ocean University of China Qingdao PR China Physical Sciences Division, Pacific Northwest National Laboratory, 902 Battelle Boulevard, P.O. Box 999, MS K8-88, Richland, Washington 99352, United States; State Key Laboratory of Precision Spectroscopy, East China Normal University, Shanghai 200062, China; State Key Laboratory of High Field Laser Physics, Shanghai Institute of Optics and Fine Mechanics, Chinese Academy of Sciences, Shanghai 201800, China Department of Chinese Medicine Beijing Children's Hospital Affiliated to Capital Medical University Beijing China State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China Department of Respiratory and Critical Care Medicine, Sichuan Provincial People’s Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas 77555 Dalton Cardiovascular Research Center Columbia Missouri USA Department of Endocrinology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. Department of Pharmacology, Zhongshan School of Medicine, Sun Yat-Sen University Beijing National Laboratory for Molecular Sciences (BNLMS), CAS Key Laboratory of Molecular Nanostructure and Nanotechnology, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China; Zhejiang Tiandi Environmental Protection Technology Co., Ltd, Hangzhou 310003, China; University of Chinese Academy of Sciences, Beijing 100049, China Department of Chemistry, Tsinghua University, Beijing 100084, P.R. China School of Medicine & Holistic Integrative Medicine Nanjing University of Chinese Medicine Nanjing Jiangsu China Department of Rehabilitation, Hangzhou Sanatorium of PLA, Hangzhou 310007, Zhejiang, China. National Key Laboratory of Crop Genetic Improvement and National Centre of Plant Gene Research, Huazhong Agricultural University, Wuhan 430070, China Division of Endocrinology, Tongji Hospital, Huazhong University of Science and Technology *Children’s Research Institute, Departments of; †Pediatrics and; ‡Molecular Virology, Immunology and Medical Genetics, and Beijing Key Laboratory of Energy Conversion and Storage Materials and College of Chemistry, Beijing Normal University, Beijing 100875, China Center for Translational Neuroscience, Department of Neurology, Case Western Reserve University School of Medicine, SOM E504, 10900 Euclid Avenue, Cleveland, OH 44120 Department of Colloid Chemistry, Max Planck Institute of Colloids and Interfaces, D-14424 Potsdam, Germany School of Chemistry and Environment, Guangzhou Key Laboratory of Materials for Energy Conversion and Storage, Guangdong Provincial Engineering Technology Research Center for Materials for Energy Conversion and Storage, South China Normal University, Guangzhou 510006, P. R. China Shenzhen Key Laboratory of Pathogen and Immunity, National Clinical Research Center for Infectious Disease, State Key Discipline of Infectious Disease, Shenzhen Third People's Hospital, Second Hospital Affiliated to Southern University of Science and Technology, Shenzhen, China Department of Physiology Zhejiang Chinese Medical University Hangzhou China Institute for Computational and Mathematical Engineering, Stanford University, Stanford, CA 94305; Department of Rehabilitation Medicine, Wuxi Rehabilitation Hospital, Wuxi, Jiangsu, China Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, School of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, P.R. China Department of Hematology and Hematology Research Laboratory West China Hospital Sichuan University Chengdu China Department of Public Health, Southwest Medical University, Luzhou, China. Department of Dermatology, Third Xiangya Hospital of Central South University, Changsha, Hunan 410013, P.R. China Neurology Department Affiliated Hospital of Jining Medical University Jining Shandong China; Geriatric Department the Second Clinical Medicine College of Jining Medical University Jining Shandong China Department of Chinese Medicine Beijing Children's Hospital Beijing China Department of Gastroenterology, The Fourth Affiliated Hospital of China Medical University, Shenyang 110000, Liaoning Province, China Division of Anti-Tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, P. R. China From the Dalton Cardiovascular Research Center (P.S.C., S.R.E., A.J.S., Z.N., M.L., L.A.M.-L., Y.Y., M.J.D., G.A.M., M.A.H.) and Departments of Biological Engineering (S.R.E., A.J.S., M.J.D., G.A.M., M.A.H.) and Medical Pharmacology and Physiology (L.A.M.-L., M.J.D., G.A.M., M.A.H.), University of Missouri, Columbia, MO; Department of Anesthesiology, Medical College of Wisconsin and Veterans Affairs Medical Center, Milwaukee, WI (P.S.C.); Department of Pharmacology, University of Oxford, Oxford,... State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu, Sichuan, People’s Republic of China Fujian Provincial Key Laboratory of Zoonosis Research (Fujian Center for Disease Control & Prevention), No. 386 Chong’an Road, Jin’an District, Fuzhou, 350012, China Department of Endocrinology and Metabolism, Lanzhou University Second Hospital, Lanzhou, China. Division of Endocrinology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, Central China Normal University, Wuhan 430079, P. R. China Prenatal Diagnosis Center of Jiangxi Women and Children's Hospital, Nanchang, Jiangxi 330006 P.R. China. lyq0914@126.com. Jining Medical University, Jining, Shandong 272067, China College of Animal Science and Technology, Yunnan Agricultural University, Kunming, Yunnan Province, 650201, PR China; State Key Laboratory of Veterinary Etiological Biology, Key Laboratory of Veterinary Parasitology of Gansu Province, Lanzhou Veterinary Research Institute, CAAS, Lanzhou, Gansu Province, 730046, PR China. Department of Neurosurgery Jining No.1 People's Hospital Jining China Department of Nephrology, Renji Hospital, School of Medicine Shanghai Jiao Tong University Shanghai China Department of Pharmacology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520 Department of Pathology Nangjing Stomatological Hospital, Medical School of Nanjing University Nanjing China Department of Antibody and Protein Engineering, 3sBio Inc, Pudong, Shanghai, China Division of Endocrinology, Department of Internal Medicine, Tongji Hospital Tongji Medical College, Huazhong University of Science and Technology Wuhan China; Branch of National Clinical Research Center for Metabolic Diseases Wuhan China School of Environmental & Safety Engineering, Changzhou University, Changzhou 213164, Jiangsu, China. School of Public Health (Shenzhen) Sun Yat‐Sen University Guangzhou China; Guangdong Engineering Technology Center of Nutrition Transformation Guangzhou China Department of Nephrology, The Third Affiliated Hospital of Soochow University, Changzhou, P.R. China College of Life Sciences, Jilin University, Changchun 130012, PR China Department of Cardiovascular Medicine, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China Key Laboratory for Biomedical Effects of Nanomaterials & Nanosafety; Institute of High Energy Physics; Chinese Academy of Sciences; Beijing 100049; China Key Laboratory of Digital Quality Evaluation of Chinese Materia Medical of State Administration of TCM, China; Engineering & Technology Research Center for Chinese Materia Medical Quality of Guangdong Province, Guangdong Pharmaceutical University, Guangzhou, China Department of Laboratory Medicine, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou 563003, P.R. China Department of Neurology, Maoming People’s Hospital, Maoming, Guangdong, China Department of Nutrition, School of Public Health, Sun Yat-Sen University, Guangzhou 510080, People’s Republic of China Guangdong-Hong Kong-Macao Joint Laboratory for Contaminants Exposure and Health, Guangdong Key Laboratory of Environmental Catalysis and Health Risk Control, Institute of Environmental Health and Pollution Control, Guangdong University of Technology, Guangzhou 510006, P. R. China Key Laboratory for Applied Surface and Colloid Chemistry National Ministry of Education; Shaanxi Engineering Lab for Advanced Energy Technology School of Materials Science and Engineering Shaanxi Normal University Xi'an 710062 P. R. China Departments of 1Medical Pharmacology and Physiology and Hospital of Chengdu University of Traditional Chinese Medicine; Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, China. School of Public Health (Shenzhen) Sun Yat‐sen University Guangzhou China; Guangdong Provincial Key Laboratory of Food, Nutrition and Health School of Public Health Sun Yat‐sen University (Guangzhou Campus) Guangzhou China Department of Hematology, West China Hospital/State Key Laboratory of Biotherapy and Cancer Center Sichuan University Chengdu China Department of Cardiology, The Third Xiangya Hospital of Central South University, Changsha, Hunan, China (mainland) Department of Pediatric Endocrinology and Inherited Metabolic Diseases, Children's Hospital of Fudan University, Shanghai, China. Department of Vascular Surgery, The First Hospital of Hebei Medical University, Shijiazhuang, China; Hebei Key Laboratory of Colorectal Cancer Precision Diagnosis and Treatment, The First Hospital of Hebei Medical University, Shijiazhuang, China Affiliated Hospital of Zunyi Medical College, China Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, People's Republic of China. Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University Department of Nutrition, School of Public Health, Sun Yat-sen University (Northern Campus), Guangzhou, Guangdong Province, China; Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-sen University (Northern Campus), Guangzhou, Guangdong Province, China; School of Public Health (Shenzhen), Sun Yat-sen University, Guangzhou, Guangdong Province, China Department of Endocrinology, Affiliated Hospital of Zunyi Medical University; Zunyi; China Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province; School of Chemistry and Chemical Engineering; Lanzhou University; Lanzhou 730000; PR China Institute of Materia Medica, Chinese Academy of Medical Sciences, Peking Union Medical College (State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Ministry of Health Key Laboratory of Biosynthesis of Natural Products), Beijing 100050, China Division of Endocrinology Department of Internal Medicine Tongji Medical College Tongji Hospital Huazhong University of Science and Technology Wuhan China Key Laboratory of Medicinal Chemistry and Molecular Diagnosis (Hebei University), Ministry of Education; Key Laboratory of Chemical Biology of Hebei Province, Hebei University, Baoding, 071002, P. R. China; Department of Immunology, School of Basic Medical Science, Hebei University, Baoding 071002, P. R. China Liaoning Key Laboratory of Molecular Recognition and Imaging, School of Life Science and Biotechnology, Dalian University of Technology, No. 2 Linggong Road, Dalian, Liaoning 116023, P. R. China Southwest Jiaotong University School of Computing and Artificial Intelligence, , Chengdu, China; Ministry of Education Engineering Research Center of Sustainable Urban Intelligent Transportation, , China; Southwest Jiaotong University Artificial Intelligence Research Institute, , Chengdu, China A. A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts Institute of Microelectronics College of Food and Biological Engineering Jimei University Xiamen China College of Veterinary Medicine, South China Agricultural University, Guangzhou, China UCLA School of Dentistry, Los Angeles, CA 90095, USA; Department of Stomatology, Zhongnan Hospital, Wuhan University, Wuhan 430071, China Center for Stem Cell Research and Application, Tongji Medical College Union Hospital, Huazhong University of Science and Technology, Wuhan 430022, Hubei Province, China. Department of Biliary and Pancreatic Surgery/Cancer Research Center Affiliated Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China Jiangsu Key Laboratory for Horticultural Crop Genetic Improvement, Institute of Vegetable Crops, Jiangsu Academy of Agricultural Sciences, Nanjing, China Heilongjiang Key Laboratory for Animal Disease Control & Pharmaceutical Development, College of Veterinary Medicine, Northeast Agricultural University, Harbin, Heilongjiang 150030, PR China College of Rehabilitation Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, China Department of Pharmacology, Anhui Medical University, Key Laboratory of Anti-inflammatory and Immunopharmacology, Ministry of Education, Hefei, Anhui 230032, P.R. China Department of General Surgery, the First Medical Centre, Chinese PLA General Hospital, Beijing, China Laboratoire de Physique et Chimie des Nano-objets Institut National des Sciences Appliquées 31077 Toulouse, Cedex 4 France Department of Neurology The Third Xiangya Hospital of Central South University No. 38 Tongzipo Road Yuelu District Changsha Hunan 410006 P.R. China Department of Endocrinology Cardiac Care Unit, The Traditional Hospital Affiliated to Xinjiang Medical University, �r�mqi, Xinjiang 830001, P.R. China State Key Laboratory of Precision Spectroscopy, and Department of Physics; East China Normal University; Shanghai 200062; China a The Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education & Institute of Materia Medica , Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing, 100050, China Institute of Biomedical Engineering, School of Control Science and Engineering, Shandong University Jinan Shandong 250061 China Department of Metabolism and Endocrinology Metabolic Syndrome Research Center Key Laboratory of Diabetes Immunology Ministry of Education National Clinical Research Center for Metabolic Diseases The Second Xiangya Hospital of Central South University Changsha China Department of Obstetrics and Gynaecology, the First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi China Institute of Microelectronics, Chinese Academy of Sciences Department of Gastroenterology, People’s Hospital of Ningguo, Ningguo Collaborative Innovation Center for Vessel Pollution Monitoring and Control, Dalian Maritime University, 116026 Dalian, China Department of Neurology The Third Xiangya Hospital Central South University Changsha China Department of Pediatric Hematology, Maternal and Child Health Hospital of Hubei Province, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430031, P.R. China Department of Radiology, Lanzhou General Hospital of PLA, Lanzhou 730050, China. yangyan-yy.2008@yahoo.com.cn Collaborative Innovation Center of Chemistry for Energy Materials; State Key Laboratory of Physical Chemistry of Solid Surface and Department of Chemistry; College of Chemistry and Chemical Engineering; Xiamen University; Xiamen 361005 School of Mechanical Engineering, Sichuan University, Chengdu 610065, China Xiangya School of Stomatology, Central South University; Hunan Key Laboratory of Oral Health Research, Changsha 410078. yy.0225@163.com. Department of Restoration, Xiangya Stomatological Hospital, Central South University, Changsha 410078. yy.0225@163.com. National Clinical Research Center for Metabolic Diseases, Metabolic Syndrome Research Center, Key Laboratory of Diabetes Immunology, Ministry of Education, and Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China School of Dentistry University of California–Los Angeles Los Angeles California Department of Hematology, Dalian Medical University Second Hospital, Dalian 116027, Liaoning Province, China. State Key Laboratory of Material Processing and Die & Mold Technology School of Materials Science and Engineering Huazhong University of Science and Technology Wuhan 430074 China State Key Laboratory of Protein and Plant Gene Research Peking‐Tsinghua Center for Life Sciences, College of Life Sciences, Peking University Beijing 100871 China Department of General Surgery, Taihe Hospital, Hubei University of Medicine, Shiyan City, China; * Both the authors contributed equally to this article Experimental Medicine Center, Tongji Hospital, Tongji Medical College,Huazhong University of Science and Technology,Wuhan,China Experimental Medicine Center, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan China Department of Oral and Maxillofacial Surgery, Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, China School of Materials Science and Engineering, Guangdong Provincial Key Laboratory of Advanced Energy Storage Materials, South China University of Technology, Guangzhou 510641, China State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College , Beijing 100050 , China; Key Laboratory of Biosynthesis of Natural Products of National Health Commission of the People's Republic of China, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College , Beijing 100050 , China School of Life Sciences Jilin University Changchun PR China College of Horticulture, Shanxi Agricultural University, Jinzhong 030801, China Department of Radiation Oncology, General Hospital of Ningxia Medical University, Yinchuan, Ningxia 750004, China; Cancer Institute, Ningxia Medical University, Yinchuan, Ningxia 750004, China Department of Chemistry, Southern Methodist University, Dallas, Texas 75275, United States Ophthalmology Department, First Affiliated Hospital of Jinan University, Guangzhou, China 3Institute of Ophthalmology, Medical College, Jinan University, Guangzhou, China Department of Gastroenterology, Qingdao Municipal Hospital the Affiliated Municipal Hospital of Qingdao University Qingdao China Beijing Key Laboratory of Pediatric Respiratory Infection Diseases Key Laboratory of Major Diseases in Children Ministry of Education National Clinical Research Center for Respiratory Diseases National Key Discipline of Pediatrics (Capital Medical University) Beijing Pediatric Research Institute Beijing Children’s Hospital Capital Medical University National Center for Children’s Health Beijing China Dalton Cardiovascular Research Center University of Missouri‐Columbia Columbia Missouri USA State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China School of Medicine & Holistic Integrative Medicine Nanjing University of Chinese Medicine Nanjing Jiangsu China; Key Laboratory of Chinese Medicine for Prevention and Treatment of Neurological Diseases Nanjing University of Chinese Medicine Nanjing Jiangsu China Natural Product Laboratory, Department of Food Science and Technology, Huazhong Agricultural University, Wuhan, Hubei 430070, People’s Republic of China Inner Mongolia Agricultural University, Key Lab of Germplasm Innovation and Utlization of Triticeae Crop at Universities of Inner Mongolia Autonomous Region, Inner Mongolia Agricultural University, Hohhot, Inner Mongolia, China School of Chemistry Beijing Advanced Innovation Center for Biomedical Engineering Beihang University Beijing 100191 China LPCNO; UMR 5215; Université de Toulouse-CNRS; INSA; UPS Department of Health Policy Research, Shanghai Health Development Research center, Shanghai Medical Information Center Beijing Institute of Technology Departments of Biological Engineering, Electrical Engineering, and Physiology, and Dalton Cardiovascular Research Center, University of Missouri, Research Park Drive, Columbia, MO 65211 United Graduate School of Agricultural Science, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan Department of Ophthalmology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Province, 510504, China Department of Pediatric Hematology, Maternal and Child Health Hospital of Hubei Province, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430070, Hubei Province, China. College of Mining, Guizhou University, Guiyang 550025, China State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100050, China From the Department of Nutrition, School of Public Health, Sun Yat-Sen University (Northern Campus), Guangzhou, Guangdong Province, People’s Republic of China (D.W., X.Y., M.X., Y.Y., D.L., X.L., F.S., W.L.); and Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Department of Nutrition, School of Public Health, Sun Yat-Sen University (Northern Campus), Guangzhou, Guangdong Province, People’s Republic of China (D.W., M.X., Y.Y., D.L., W.L.). Department of Endocrinology, Affiliated Hospital of Zunyi Medical University, Zunyi, 563000 Guizhou, China Department of Internal Medicine, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, Hubei 430030, P.R. China Department of Gastroenterology, First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China The Jackson Laboratory, 1650 Santa Ana Avenue, Sacramento, CA 95838, USA; Leo Universal, Inc., Torrance, CA 90505, USA Department of Gynecology, Dongfang Hospital of Beijing University of Chinese Medicine, Beijing 100078, China. Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, 430071 Wuhan, China; Department of Pathology and Cancer Institute, Smilow Research Center, New York University School of Medicine, New York, New York, USA Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Department of Nutrition, School of Public Health, Sun Yat-Sen University [Northern Campus]; Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Department of Nutrition, School of Public Health, Sun Yat-Sen University [Northern Campus] Key Laboratory of the Three Gorges Reservoir Region’s Eco-Environment, Ministry of Education, School of Urban Construction and Environmental Engineering, Chongqing University, Chongqing 400045, China; National Centre for International Research of Low-Carbon and Green Buildings, Chongqing University, Chongqing, China 1Department of Molecular and Cellular Oncology, Department of Obstetrics and Gynecology West China Second University Hospital Sichuan University Chengdu China College of Environmental Sciences, Sichuan Agricultural University, Chengdu 611130, China Department of Orthodontics, Ninth People's Hospital Affiliated to Shanghai Jiao Tong University, School of Medicine, Shanghai Key Laboratory of Stomatology, Shanghai, China. Agricultural Product Processing and Storage Laboratory, School of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, China; China Light Industry Key Laboratory of Food Intelligent Detection & Processing, School of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, China Department of Pharmacy, Guangdong Second Provincial General Hospital, Guangzhou 510317, China Department of Obstetrics and Gynecology, The Affiliated Baiyun Hospital of Guizhou Medical University Qilu University of Technology (Shandong Academy of Sciences) LPCNO Université de Toulouse, UPS, INSA, CNRS 135 avenue de Rangueil 31077 Toulouse France State Key Laboratory of Precision Spectroscopy, School of Physics and Electronic Science, East China Normal University, Shanghai 200241, China Department of Stomatology, Zhongnan Hospital of Wuhan University, Wuhan 430071, Hubei, China Jining Medical University, Jining, Shandong 272067, China; Affiliated Hospital of Jining Medical University, Jining, Shandong 272067, China Department of Endocrinology Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital Chengdu Sichuan China Shunde Heping Surgery Hospital Affiliated to Guangzhou University of Chinese Medicine, Shunde 528308, China.E-mail: peteryang@globaldoctor.com.au. Key Laboratory of Medicinal Chemistry and Molecular Diagnosis (Hebei University), Ministry of Education, Key Laboratory of Chemical Biology of Hebei Province, Hebei University, Baoding, 071002, P. R. China; Department of Immunology, School of Basic Medical Science, Hebei University, Baoding 071002, P. R. China Rutgers New Jersey Medical School, Newark, USA Graduate School, Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region 530021, P.R. China Department of Organic Chemistry School of Pharmacy Second Military Medical University Shanghai 200433 China Department of Clinical Laboratory Science , The 117th Hospital of PLA , Hangzhou 310013 , China Department of Cardiovascular Surgery Fuwai Hospital Beijing China Department of Rehabilitation Medicine, Wuxi Rehabilitation Hospital, Wuxi, Jiangsu Province, China Key Laboratory of Medical Electrophysiology, Ministry of Education, Collaborative Innovation Center for Prevention and Treatment of Cardiovascular Disease/Institute of Cardiovascular Research, Southwest Medical University, Luzhou, Sichuan, China (mainland) Key Laboratory of Veterinary Public Health of Ministry of Agriculture, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences , Harbin, China School of Pharmacy, Zhejiang University of Technology, Hangzhou, China Jiangsu Normal University State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China;; Key Laboratory of Biosynthesis of Natural Products of National Health commission of the People's Republic of China, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China; Department of Intelligent Science and Technology, Northwestern Polytechnical University School of Automation , 127 Youyi Road, 710072 Shaanxi , China Department of Nutrition, School of Public Health, Sun Yat-sen University (Northern Campus), Guangzhou 510080, People’s Republic of China; Canadian Blood Services, Toronto, Ontario M5G 2M1, Canada Department of Nutrition; School of Public Health; Sun Yat-Sen University; Guangzhou P. R. China; Guangdong Provincial Key Laboratory of Food; Nutrition and Health; Guangzhou P. R. China National Engineering Research Center of Edible Fungi, Shanghai Academy of Agricultural Sciences, Shanghai 201403, P. R. China Texas A&M AgriLife Research and Extension Center, Texas A&M AgriLife Research, Amarillo, TX, United States of America Ophthalmology Department, First Affiliated Hospital of Jinan University, Guangzhou, 510632, China.; Institute of Ophthalmology, Medical College, Jinan University, Guangzhou, 510632, China. Department of Integrated Chinese and Western Medicine, Jilin Cancer Hospital, Changchun, Jilin 130000, China Institute for Advanced Studies Wuhan University Wuhan 430072 China Department of Oncology, The First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui, China (mainland) Linyi Academy of Agricultural Science, Linyi, China Sichuan Chidingshengtong Biotechnology Co., Ltd., Chengdu, Sichuan, P.R. China; E’mei Mountainside Health Management Co.Ltd., Chengdu, Sichuan, P.R. China State Key Laboratory of Transducer Technology Aerospace Information Research Institute Chinese Academy of Sciences Beijing 100190 China; University of Chinese Academy of Sciences Beijing 100049 China Cabot Microelectronics Aurora Illinois USA Department of Liver Disease, Qilu Hospital, Shandong University, Jinan 250012, China. Division of Endocrinology and Department of Internal Medicine, Tongji Hospital Tongji Medical College, Huazhong University of Science and Technology Wuhan China Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, Kunming 650031, China Department of Hematology, The Affiliated Hospital of Jilin University, Changchun, People’s Republic of China Department of Nephropathy, Lanzhou University Second Hospital, Lanzhou, China Guangdong University of Technology Synergy Innovation Institute of GDUT Shantou China; School of Environmental Science and Engineering, Institute of Environmental Health and Pollution Control Guangdong University of Technology Guangzhou China School of Computer Science, Xi’an Polytechnic University , Xi’an, 710048, China Key Laboratory of Veterinary Public Health of Yunnan Province, College of Veterinary Medicine, Yunnan Agricultural University, Kunming, Yunnan Province 650201, China State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People’s Republic of China State Key Laboratory of Silkworm Genome Biology, Southwest University, 400715 Chongqing, China; Department of Oncology, The First Affiliated Hospital of Bengbu Medical College Bengbu 233004, Anhui Province, China. Institute for Biomedical Sciences of Pain, Tangdu Hospital The Fourth Military Medical University Xi'an 710038 China; Institute for Functional Brain Disorders, Tangdu Hospital The Fourth Military Medical University Xi'an 710038 China; Key Laboratory of Brain Stress and Behavior, PLA Xi'an 710038 China From the The First Affiliated Hospital of Chongqing Medical University, 2Chongqing Key Laboratory of Ophthalmology and 3Chongqing Eye Institute, Chongqing, People's Republic of China; the 4Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, Pe Nursing Department, Ren Ji Hospital, School of Medicine Shanghai Jiao Tong University Shanghai China Department of Endocrinology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; Branch of National Clinical Research Center for Metabolic Disease, Hubei, China Department of Orthodontics, State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China e-mail: yuli@scu.edu.cn School of Environmental Science and Engineering, Institute of Environmental Health and Pollution Control, Guangdong University of Technology, Guangzhou 510006, Guangdong, China. Department of Spine Surgery, Xiangya Hospital, Central South University, 87#Xiangya Road, Changsha 410008, Hunan, China; Hunan Engineering Laboratory of Advanced Artificial Osteo-materials, Xiangya Hospital, Central South University, 87#Xiangya Road, Changsha 410008, Hunan, China School of Chemistry, Beijing Advanced Innovation Center for Biomedical Engineering, Beihang University, Beijing 100191, China Oxford Nanopore Technologies, Inc., NY 10013, USA. Authors' Affiliations: 1Department of Melanoma Medical Oncology, The Center for Cancer Immunology Research, The University of Texas MD Anderson Cancer Center, Houston, Texas; and 2Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan Department of General Practice, First Affiliated Hospital of Air Force Military University (Xijing Hospital), Xi’an 710032, Shaanxi, China Collaborative Innovation Center for Vessel Pollution Monitoring and Control, Dalian Maritime University, Dalian116026, China Department of Hematology & Cancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, P.R. China School of Food and Biological Engineering; Shaanxi University of Science and Technology; Xi’an 710021; China Drug Discovery Department, Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, Florida 33612, United States Department of Anesthesiology, The First Affiliated Hospital, University of South China, Hengyang, Hunan 421001, P.R. China Department of Pharmacy, Second Xiangya Hospital Central South University Changsha Hunan China China Resources Saike Pharmaceutical Co., Ltd Beijing China Department of Hematology, The First Hospital, Jilin University, Changchun, China Department of Orthopaedic Surgery The First Affiliated Hospital of Soochow University Suzhou Jiangsu China School of Medicine and Life SciencesNanjing University of Chinese Medicine Nanjing China; Key Laboratory of Chinese Medicine for Prevention and Treatment of Neurological DiseasesNanjing University of Chinese Medicine Nanjing China; State Key Laboratory Cultivation Base for Traditional Chinese Medicine Quality and EfficacyNanjing University of Chinese Medicine Nanjing China; Key Laboratory of Drug Target and Drug for Degenerative Disease of Jiangsu ProvinceNanjing University of Chinese Medicine Nanjing China Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases, Department of Pharmacology of Chinese Materia Medica China Pharmaceutical University 24 Tong Jia Xiang Nanjing 210009 China Institute of Edible Fungi, Shanghai Academy of Agricultural Sciences, Shanghai, People’s Republic of China Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital College of Health Science and Nursing Wuhan Polytechnic University Wuhan China Department of Emergency Medicine, Northern Jiangsu People’s Hospital, Yangzhou University College of Clinical Medicine, China State Key Laboratory of Oral Disease, West China Hospital of Stomatology, Center of Growth Metabolism and Aging, Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, China.; National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, China.; National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.; Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, China. Experimental Medicine Center Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China Hebei Key Laboratory of Chinese Medicine Research on Cardio-Cerebrovascular Disease, Pharmaceutical College, Hebei University of Chinese Medicine, Shijiazhuang, Hebei 050200, China Laboratory of Pharmacology and Toxicology, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China Nursing Department, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China LPCNO, Université de Toulouse, 135 Avenue de Rangueil, 31077 Toulouse, France Authors' Affiliations: 1Laboratory of Endocrinology and Metabolism, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Sichuan, People's Republic of China; and 2Maine Institute for Human Genetics & Health, Brewer, Maine Department of Endocrinology, Affiliated Hospital of Zunyi Medical College, Zunyi, China. Hypertension Specialist Ward, Third Xiangya Hospital, Central South University, Changsha 410013, China. University of California at Los Angeles, School of Dentistry, Los Angeles, CA 90095, USA; Department of Stomatology, Zhongnan Hospital, Wuhan University, Wuhan 430071, China Prenatal Diagnosis Center of Jiangxi Women and Children's Health Care Hospital, Nanchang, Jiangxi 330006, China. lyq0914@126.com. Department of Orthopaedic Surgery, First Affiliated Hospital, China Medical University, Shenyang, Liaoning, China (mainland) The Laboratory for Biomechanics of Animal Locomotion, Graduate University of Chinese Academy of Sciences, Beijing 100049, China/Department of Mechanics and Mechanical Engineering, University of Science and Technology of China,Hefei 230026, China School of Life Sciences Jilin University Changchun P.R. China Department of Infectious Diseases, General Hospital of Ningxia Medical University, Yinchuan, China Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education; School of Life Sciences; Jilin University; Changchun 130012; China School of Environmental and Civil Engineering, Jiangsu Key Laboratory of Anaerobic Biotechnology, Jiangnan University, Wuxi 214122, China Department of Immunology Tongji Medical College Huazhong University of Science and Technology Wuhan China; Laboratory of Infection and Immunity Wuhan Institute of Virology Chinese Academy of Sciences Wuhan China Key Laboratory of Medicinal Chemistry and Molecular Diagnosis (Hebei University), Ministry of Education, Key Laboratory of Chemical Biology of Hebei Province, Hebei University, Baoding, P. R. China; Department of Immunology, School of Basic Medical Science, Hebei University, Baoding 071002, P. R. China State Key Laboratory of Urban Water Resource and Environment School of Chemistry and Chemical Engineering Harbin Institute of Technology Harbin 150001 China Guangxi Key Lab of Agricultural Resources Chemistry and Biotechnology; College of Chemistry and Food Science; Yulin Normal University; Yulin 537000; PR China *Center for Molecular and Human Genetics, Columbus Children’s Research Institute; and Departments of; †Molecular Virology, Immunology, and Medical Genetics and Department of Medicinal Chemistry, University of Kansas, 1251 Wescoe Hall Drive, University of Kansas, Lawrence, Kansas 66045-7582, and Department of Physical Sciences, University of New Brunswick, Saint John, NB, Canada E2L 4L5 Tropical Crops Genetic Resources Research Institute, Chinese Academy of Tropical Agricultural Sciences, Danzhou 571737, China Institute of Edible Fungi, Shanghai Academy of Agriculture Sciences, National Engineering Research Center of Edible Fungi, Key Laboratory of Edible Fungi Resources and Utilization (South), Ministry of Agriculture, Shanghai 201403, China Dalton Cardiovascular Research Center, University of Missouri, Columbia (M.A.H., Y.Y., J.R.S.) Department of Endocrinology, 302 Military Hospital of China, Beijing, China. Meteorological Medical Research Center, Panzhihua Central Hospital, Panzhihua, Sichuan Province, China; Dali University, Dali, Yunnan Province, China; Department of Respiratory and Critical Care Medicine, Panzhihua Central Hospital, Panzhihua, Sichuan Province, China College of Materials Science and Engineering, Central South University of Forestry and Technology, Changsha 410004, China; College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China |
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