http://rdf.ncbi.nlm.nih.gov/pubchem/author/MD5_defa3b2a870594c31ba359e8b2db6f0f
Outgoing Links
| Predicate | Object |
|---|---|
| family-name | Yong Chen Chen |
| name | Yong Chen |
| given-name | Yong |
| organization-name | Shanghai Key Laboratory of Trustworthy Computing, East China Normal University 1 , Shanghai 200062, People's Republic of China; Department of Physics, Zhejiang Normal University 2 , Jinhua 321004, People's Republic of China Lanzhou University 2 Institute of Theoretical Physics, , Lanzhou 730000, China Shenzhen Institute of Respiratory Diseases, Second Clinical Medical College (Shenzhen People’s Hospital), Jinan University, Guangzhou, China; The First Affiliated Hospital (Shenzhen People's Hospital), Southern University of Science and Technology, Shenzhen, China Proteomics Core Facility, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA Department of Hepatobiliary Surgery First Affiliated Hospital, Chongqing Medical University Chongqing China Department of Chemistry; State Key Laboratory of Elemento-Organic Chemistry; Collaborative Innovation Center of Chemical Science and Engineering (Tianjin); Nankai University; Tianjin 300071 Department of Gastroenterological Surgery, Transplant, and Surgical Oncology, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan Xuzhou Center for Disease Prevention and Control Xuzhou Jiangsu Province China Division of Biostatistics School of Public Health, the University of Texas Health Science Center at Houston Houston TX USA Department of Pathophysiology, School of Basic Medicine, Tongji Medical College, Institute of Brain Research, Key Laboratory of Neurological Diseases, Ministry of Education, Hubei Provincial Key Laboratory of Neurological Diseases, Huazhong University of Science and Technology, Wuhan, China Department of Cardiology, Yinchuan Second People's Hospital, Yinchuan, Ningxia Hui Autonomous Region, China; Guangdong Key Laboratory of Animal Conservation and Resource Utilization Guangdong Public Laboratory of Wild Animal Conservation and Utilization Institute of Zoology Guangdong Academy of Sciences Guangzhou China Departments of †Medicinal Chemistry, ‡Internal Medicine, §Pathology, ⊥Biological Chemistry, and ∥Pharmacology, ∇Comprehensive Cancer Center, and ⊗Howard Hughes Medical Institute, University of Michigan, Ann Arbor, Michigan 48109, United States Division of Gastroenterology and Hepatology, NHC Key Laboratory of Digestive Diseases, State Key Laboratory for Oncogenes and Related Genes, Renji Hospital, School of Medicine, Shanghai JiaoTong University, Shanghai Institute of Digestive Disease, Middle Shandong Road, Shanghai 200001, China Department of Chemistry; State Key Laboratory of Elemento-Organic Chemistry; Nankai University; Tianjin 300071; P. R. China Department of Chemistry, City University of New York College of Staten Island, Staten Island, New York 10314 Department of Hepatobiliary Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China. gdwk@fmmu.edu.cn Department of Interventional Radiology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, P.R.China. Sichuan Key Laboratory of Medical Imaging and Department of Radiology Affiliated Hospital of North Sichuan Medical College Nanchong Sichuan China Guangzhou Institute of Energy Conversion, Chinese Academy of Sciences, Guangzhou 510640, China, and National Institute of Advanced Industrial Science and Technology, Nagoya 463-8560, Japan Stroke Branch, NINDS, NIH, Bethesda, Maryland, USA Department of Food Science and Nutrition, Fuli Institute of Food Science, Zhejiang Key Laboratory for Agro-Food Processing, Zhejiang University, Hangzhou, 310058, China Chinese PLA Institute for Disease Control and Prevention, Beijing, China Department of Gastroenterology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, P.R. China Department of Pediatric Surgery, KK Women's and Children's Hospital, Singapore, Singapore Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, TX 77555-1069 Lab of Natural Product Drugs, Cancer Center, West China Medical School, West China Hospital, Sichuan University, Chengdu, China Department of Biomedical Engineering, Purdue School of Engineering and Technology, Indiana University-Purdue University at Indianapolis, Indianapolis, Indiana, USA; Jinchu University, Hubei, P.R. China Science and Technology Department, State Tobacco Monopoly Administration, Beijing, China College of Chemistry State Key Laboratory of Elemento-Organic Chemistry Nankai University Tianjin 300071 P. R. China; Collaborative Innovation Center of Chemical Science and Engineering (Tianjin) Tianjin 300072 P. R. China Perelman School of Medicine, Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania Department of Hepatobiliary Surgery The First Affiliated Hospital of Chongqing Medical University Chongqing China Department of Neurology, Center for Translational Neuroscience, Duke University Medical Center, Durham, NC 27710, USA Bio-Technology of Traditional Chinese Medicine Key Lab of Hubei Province, Hubei University, Wuhan, China. cy101610@npc.gov.cn *Department of Biological Chemistry, University of Michigan Medical School, 5413 Medical Science I, 1301 Catherine Road, Ann Arbor, MI 48109-0606; and Department of Hepatobiliary Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China Department of Neurology Jiangxi Provincial Children's Hospital Nanchang Jiangxi China Guangzhou Institute of Forestry and Landscape Architecture, Guangzhou Collaborative Innovation Center on Science-Tech of Ecology and Landscape, Guangzhou, China Department of Urology the Affiliated Hospital of Southwest Medical University Luzhou China Department of Chemistry, University of Waterloo, Waterloo, Ontario N2L 3G1, Canada Section of Neonatology, Department of Pediatrics, Rush Children's Hospital, Rush Presbyterian St. Luke's Medical Center, Chicago, Illinois 60612 Department of Cardiology Fourth Affiliated Hospital of China Medical University Shenyang China College of Pharmacy Nanjing University of Chinese Medicine Nanjing 210046 People's Republic of China Department of Mechanical and Aerospace Engineering California Nano Systems Institute University of California Los Angeles California 90095 USA College of Mechanical and Electronic Engineering, Nanjing Forestry University Nanjing China Beihang University 1 Center of Soft Matter Physics and its Application, , Beijing 100191, China; Beihang University 2 School of Physics and Nuclear Energy Engineering, , Beijing 100191, China Department of Chemistry, Institute for Proteomics Technology and Applications, The George Washington University, Washington, DC 20052 Proteomics Core Facility, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland; and Institute of Genetics and Regenerative Biology, College of Life Sciences, Zhejiang University, Hangzhou, China College of Chemistry and Life Science Sichuan Provincial Key Laboratory for Structural Optimization and Application of Functional Molecules Chengdu Normal University Chengdu 611130 P. R. China Proteomics Core,National Heart, Lung and Blood Institute, NIH,Bethesda,MD Department of Neurosurgery The First Hospital of Jilin University Changchun P.R. China Fujian Key Laboratory for Monitoring and Integrated Management of Crop Pests, East China Branch of the National Center For Agricultural Biosafety Sciences, Fujian Engineering Research Center for Green Pest Management, Fuzhou Scientific Observing and Experimental Station of Crop Pests of Ministry of Agriculture and Rural Affairs, Institute of Plant Protection, Fujian Academy of Agricultural Sciences , Fuzhou 350013 , China Proteomics Core Facility, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA Nanoscale Science and Technology Laboratory, Institute for Advanced Study Nanchang University Nanchang Jiangxi China Laboratory of Radiation BiologyDepartment of Environmental Veterinary SciencesGraduate School of Veterinary MedicineHokkaido University Sapporo Japan Tianjin Enterprise Key Laboratory for Application Research of Hyaluronic Acid, Tianjin 300038, China; College of Chemistry, Nankai University, Tianjin 300071, China Guangzhou Institute of Energy Conversion; Chinese Academy of Sciences; Guangzhou 510640; China; Key Laboratory of Renewable Energy State Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai 200031, China Department of Radiology University of North Carolina Chapel Hill North Carolina USA; Biomedical Research Imaging Center (BRIC) University of North Carolina at Chapel Hill North Carolina USA Department of Biology, Ningde Teachers College, Ningde 352100, Fujian, China. chenyongxun1954@yahoo.com.cn State Key Laboratory of Marine Resource Utilization in South China Sea, Hainan Provincial Key Laboratory of Research on Utilization of Si-Zr-Ti Resources, Hainan University, Haikou 570228, China; Guangdong Key Laboratory for Hydrogen Energy Technologies, School of Materials Science and Hydrogen Energy, Foshan University, Foshan 528000, China Department of Biological Sciences, Center for Systems Biology, the University of Texas at Dallas, Richardson, TX, USA Department of Biostatistics, Epidemiology and Informatics , Perelman School of Medicine at The University of Pennsylvania , Philadelphia , PA , USA College of Chemistry, State Key Laboratory of Elemento–Organic Chemistry, Nankai University, People’s Republic of China Key Laboratory of Plant Resources, Institute of Botany, Chinese Academy of Sciences, Beijing 100093, China; China National Botanical Garden, Beijing 100093, China Key Laboratory of Photovoltaic and Energy Conservation Materials, Institute of Solid State Physics, HFIPS, Chinese Academy of Sciences, Hefei230031, China Department of Crop Cultivation and Farming System South China Agricultural University Guangzhou China Department of Rheumatology and Immunology, Hospital of Integrated Traditional Chinese and Western Medicine, Southern Medical University, Guangzhou 510330, China. PASTEUR, Department of Chemistry, École Normale Supérieure, PSL University, Sorbonne Université, CNRS, 75005 Paris, France Department of Orthopaedic Surgery No. 2 People's Hospital of Fu Yang Fuyang China Department of Neurology, Duke University Medical Center China Mobile Laboratory Response Team for Ebola in Sierra Leone, Freetown 999127, Sierra Leone. Institute of Plant Protection Fujian Academy of Agricultural Sciences Fuzhou Fujian Province China; Fujian Key Laboratory for Monitoring and Integrated Management of Crop Pests Fujian Academy of Agricultural Sciences Fuzhou Fujian Province China State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University , Guangzhou, China Key Laboratory for Thermal Science and Power Engineering of Ministry of Education, Thermal Engineering Department, Tsinghua University, Beijing 100084, China. yong-chen03@mails.tsinghua.edu.cn Key Laboratory of Molecule Synthesis and Function Discovery, College of Chemistry, Fuzhou University, Fuzhou 350108, China All authors: Department of Interventional Radiology, Nanfang Hospital, 1838 N Guangzhou Ave., Guangzhou, Guandong 510515, China. Department of Radiation Oncology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China Department of Hepatobiliary Surgery,First Affiliated Hospital, Chongqing Medical University,Chongqing,China Department of Chemistry and Biochemistry, Department of Mechanical and Aerospace Engineering, and California NanoSystems Institute, University of California, Los Angeles, 607 Charles E. Young Drive East, Los Angeles, California 90095-1569 Leibo County Center for Disease Control and Prevention, Liangshan, China Department of Tuberculosis Laboratory, Public Health Medical Center, Chongqing 400036, P.R. China Department of Radiology, the Affiliated Hospital of Hangzhou Normal University, Hangzhou 310015, China. Veterinary Department, Yangzhou University, Yangzhou, China Hewlett-Packard Laboratories, 1501 Page Mill Road, Palo Alto, California 94304, Department of Mechanical and Aerospace Engineering, University of California, Los Angeles (UCLA), Los Angeles, California 90024, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, MS 02-400, Berkeley, California 94720, and Technology Development Operations, Inkjet Technology Platform, Hewlett-Packard Company, 1000 Circle Boulevard, Corvallis, Oregon 97330 Department of General Surgery, Tianjin Medical University General Hospital, Tianjin, China; Huai’an Second People’s Hospital Huai’an Jiangsu China Hangzhou Arcvideo Technology Co., Ltd., No. 3 Xidoumen Road, Xihu, Hangzhou 310012, China Division of Biostatistics, School of Public Health, The University of Texas, Houston, USA Department of Laboratory The Affiliated Brain Hospital of Nanjing Medical University Nanjing China Research Center of Laser Fusion, CAEP 2 , Mianyang 21900, China National Heart, Lung and Blood Institute National Institutes of Health Bethesda MD USA School of Mechanical and Power Engineering, Nanjing Technology University, Nanjing 211816, China; Guangzhou Institute of Energy Conversion, Chinese Academy of Sciences, CAS Key Laboratory of Renewable Energy, Guangdong Provincial Key Laboratory of New and Renewable Energy Research and Development, No.2 Nengyuan Road, Wushan, Tianhe District, Guangzhou, Guangdong 510640, China; Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), Guangzhou 511458, China; School of Materials and Energy, Guangdong University of Technology, Guangzhou 510006, China; Institute of Urban & Rural Mining, School of Petrochemical Engineering, Changzhou University, Changzhou 213164, China Department of Plastic Surgery of Third Xiangya Hospital Changsha China; Surgical Department Emergency Department The First Hospital of Changsha Changsha China Institute of Intelligent Machines; University of Science and Technology of China Diabetes Center University of California San Francisco CA USA; Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research San Francisco CA USA; Department of Cell and Tissue Biology University of California San Francisco CA USA Key Laboratory of Molecule Synthesis and Function Discovery and Fujian Provincial Key Laboratory of Advanced Inorganic Oxygenated Materials College of Chemistry Fuzhou University Fuzhou 350116 P. R. China Department of Cardiology, West China Hospital Sichuan University Chengdu China Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, The University of Pennsylvania, Philadelphia, Pennsylvania, USA Stroke Branch, National Institutes of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA *Department of Biological Sciences and Biotechnology, State-Key Laboratory of Biomembrane and Membrane Biotechnology, Tsinghua University, Beijing 100084, China; College of Science & Ministry-Province Jointly-Constructed Cultivation Base for State Key Laboratory of Processing for Mom-Ferrous Metal and Featured Materials & Key Lab. of Nonferrous Materials and New Processing Technology & Network and Information Center, Guilin University of Technology, Guilin 541004, China School of Computer Science and Technology, Anhui Provincial Key Laboratory of Multimodal Cognitive Computation, Anhui University, Hefei, China Nanoscale Science and Technology Laboratory, Institute for Advanced Study, Nanchang University, Nanchang, Jiangxi 330031, China; College of Life Sciences, Nanchang University, Nanchang, Jiangxi 330031, China Department of Rheumatology, Huadong Hospital Affiliated to Fudan University, Shanghai 200040, China. E-mail: 417033196@qq.com. Laboratoire de Photonique et Nanostructures, CNRS, 91460 Marcoussis, France College of Biomedical Engineering, School of Chemical Engineering, Sichuan University, Chengdu 610065, China Department of Rehabilitation Medicine; Huaihe Hospital of Henan University; Kaifeng; China Department of Epidemiology & Biostatistics, School of Public Health, Peking University, Beijing 100191, China. School of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, China Department of Gastric Cancer and Soft Tissue Sarcomas; Fudan University Shanghai Cancer Center; Shanghai China; Department of Oncology; Shanghai Medical College; Fudan University; Shanghai China Department of Hepatobiliary Surgery, Xijing Hospital, Xian 710032, China; Pharmaceutical Institute, Nanjing University of Chinese Medicine, Nanjing, China Department of Biostatistics, The University of Texas School of Public Health, Houston Department of Radiology Case Western Reserve University & University Hospitals Cleveland Ohio USA Department of Clinical Laboratory, Affiliated Brain Hospital of Nanjing Medical University, Nanjing, Jiangsu 210000, P.R. China Key Laboratory of Plant Resources, The Innovative Academy of Seed Design, Institute of Botany, Chinese Academy of Sciences, Beijing, China Proteomic Core Facility, NHLBI, NIH, 10 Center Drive, Building 10 Room 8C103C Bethesda Maryland 20892 USA Department of Anesthesiology State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China, and College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China Hubei Province Key Laboratory of Biotechnology of Chinese Traditional Medicine, Hubei Collaborative Innovation Center for Green Transformation of Bio‐resources Hubei University Wuhan 430062 China Department of Radiology, Case Western Reserve University, Cleveland, OH, USA Guangxi College of Traditional Chinese Medicine, Nanning 530001. Lanzhou University 1 Institute of Theoretical Physics, , Lanzhou 730000, China; Lanzhou University 3 Key Laboratory for Magnetism and Magnetic Materials of the Ministry of Education, , Lanzhou 730000, China College of Pharmacy, Nanjing University of Chinese Medicine, 138 Xianlin Road, Nanjing, 210046, People’s Republic of China Department of Acupuncture and Physiotherapy The First Affiliated Hospital of Wenzhou Medical University Wenzhou China Lanzhou Institute of Biological Products Co., Ltd., Lanzhou, China, lzcy1@163.com. Stroke Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, U.S.A. Department of Neurology Duke University School of Medicine Durham North Carolina University of Macau,State-Key Laboratory of Analog and Mixed-Signal VLSI and IME/ECE-FST,Macao,China Department of Medicinal Chemistry, ‡Department of Internal Medicine, §Department of Pharmacology, ∥Comprehensive Cancer Center, ⊥Department of Biological Chemistry, and #Howard Hughes Medical Institute, University of Michigan, Ann Arbor, Michigan 48109, United States Departments of aNeurology, State Key Laboratory of Agricultural Microbiology, College of Plant Science and Technology, Huazhong Agricultural University , No. 1 Shizishan Road, Hongshan District, Wuhan 430070 Hubei, China Institute of Plant Protection, Fujian Academy of Agricultural Sciences, Fuzhou, China; Fujian Key Laboratory for Monitoring and Integrated Management of Crop Pests, Fuzhou, China School of Public Health, Nanjing Medical University, Nanjing 210029, China. Department of Radiation Oncology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China School of Mechanical Engineering, Nanjing Vocational University of Industry Technology, Nanjing 210023, China Department of Nephrology Wuxi People's Hospital Affiliated to Nanjing Medical University Wuxi China State Key Laboratory of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, China Center for Hospital Infection Control, Institute of Disease Control & Prevention, Academy of Military Medical Sciences, Beijing 100071, China Department of Rheumatology, Hospital of Integrated Traditional Chinese and Western Medicine, Southern Medical University, Guangzhou 510330, China. Hubei Province Key Laboratory of Biotechnology of Chinese Traditional Medicine, Hubei University, Wuhan, China; and College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China Ecole Normale Supérieure, CNRS-ENS-UPMC UMR 8640, 24 rue Lhomond, 75231 Paris, France; Institute for Integrated Cell-Material Science, Kyoto University, Kyoto 606-8507, Japan Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA Department of Biostatistics and Epidemiology University of Pennsylvania Philadelphia 19104 Pennsylvania U.S.A. Department of Statistics, Operations, and Data Science Temple University Philadelphia Pennsylvania USA Department of Physics and Center for Quantum Materials, The Hong Kong University of Science and Technology, Hong Kong, China; Department of Materials Science and Engineering, The Southern University of Science and Technology, Shenzhen 518055, China College of Geo-resources and Information, China University of Petroleum, Qingdao 266555, China. yongchenzy@upc.edu.cn Sichuan Key Laboratory of Medical Imaging and Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong; Institute for Integrated Cell-Material Sciences (WPI-iCeMS), Kyoto University, Yoshida-Ushinomiya-cho, Sakyo-ku, Kyoto 606-8501, Japan; Ecole Normale Supérieure, CNRS-ENS-UPMC UMR 8640, 24 Rue Lhomond, 75005 Paris, France College of Biological and Environmental Sciences, Zhejiang Wanli University, Ningbo, China Department of Cardiothoracic Surgery, the First Affiliated Hospital of Guangxi Medical University, Nanning, China Departments of Mechanical and Aerospace Engineering, Materials Science and Engineering, Electrical and Computer Engineering, California NanoSystems Institute, University of California , Los Angeles, California , USA School of Computer Engineering, Jimei University, Xiamen 361021, China Department of Orthopaedics ,the General Hospital of NanJing Military Command of PLA, Nanjing 210002, Jiangsu, China. chenyoong@sina.com Department of Pharmaceutics, Ghent University, Ghent, Belgium; Cancer Research Institute Ghent (CRIG), Ghent University, Ottergemsesteenweg 460, B-9000 Ghent, Belgium Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials, College of Chemistry and Chemical Engineering, Ministry of Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules, Hubei University, Wuhan 430062, P.R. China Department of Food Science, Cook College, Rutgers University, New Brunswick, NJ 08901-8520, USA. Department of Neurosurgery, The First Hospital of Jilin University, Changchun, China Key Laboratory of Photochemical Conversion and Optoelectronic Materials; Technical Institute of Physics and Chemistry & University of Chinese Academy of Sciences; Chinese Academy of Sciences; Beijing 100190; P. R. China Department of Surgery, The Eighth Affiliated Hospital, Sun Yat-Sen University, Shenzhen, China School of Chemistry and Environmental Engineering, Wuhan Institute of Technology, Key Laboratory of Novel Reactor and Green Chemical Technology of Hubei Province, Key Laboratory for Green Chemical Process of Ministry of Education, Wuhan 430074, People’s Republic of China Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, Pennsylvania; Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania Division of General and Thoracic Surgery, Translational Medicine Program, SickKids – The Hospital for Sick Children, Toronto, Ontario, Canada; Department of Pediatric Surgery, KK Women's and Children's Hospital, Singapore State Key Laboratory of Oncology in South China Department of Radiation Oncology Sun Yat‐sen University Cancer Center Guangzhou People's Republic of China Collaborative Innovation Center of Advanced Microstructures, National Laboratory of Solid State Microstructures, College of Engineering and Applied Sciences, Nanjing University, Nanjing 210093, China; Jiangsu Key Laboratory of Nano Technology, Nanjing University, Nanjing 210093, China Department of Human Anatomy and Histology and Embryology, School of BasicMedical Sciences, FujianMedical University, Fuzhou, Fujian Province, PR China California NanoSystem Institute, University of California, Los Angeles 90095, United States; Department of Biomedical Engineering, University of California, Los Angeles 90095, United States School of Materials Science and Chemical Engineering Ningbo University Ningbo 315211 China Department of Radiology The University of North Carolina at Chapel Hill Chapel Hill NC USA; Biomedical Research Imaging Center The University of North Carolina at Chapel Hill Chapel Hill NC USA The National Engineering Research Center for Bioengineering Drugs and the Technologies Institute of Translational Medicine Nanchang University Nanchang China Departments of Oncology, Northern Jiangsu People's Hospital and Clinical Medical College of Yangzhou University, Yangzhou, China Guangdong Key Laboratory for Hydrogen Energy Technologies, School of Materials Science and Hydrogen Energy, Foshan University, Foshan 528000, China Emergency Department, Taikang Tongji (Wuhan) Hospital, Wuhan, China PhD Student, Faculty of Dentistry, The University of Hong Kong, Hong Kong, China Department of Pharmacology and Center for Substance Abuse Research, Temple University School of Medicine, 3420 North Broad Street, Philadelphia, PA 19140, USA. College of Resources and Environment, Henan Institute of Engineering, Zhengzhou 451191, China Department of Biological and Environmental Sciences, Wenzhou Normal College, Wenzhou 325003, China. Department of Biomedical Engineering, Duke University, Durham, NC, USA Bio-Technology of Traditional Chinese Medicine Key Lab of Hubei Province, Hubei University, Wuhan 430062, China. cy101610@npc.gov.cn Department of Microbiology and Immunology, University of Illinois Department of Cell Biology, SUNY Downstate Health Sciences University, Brooklyn, New York Department of Neurosurgery The First Hospital of Jilin University Changchun Jilin Province 130021 China Institute of Organic Chemistry University of Vienna Währinger Strasse 38 1090 Vienna Austria Department of Biomedical Engineering, Southern University of Science and Technology, No. 1088, Xueyuan Rd., Xili, Nanshan District, Shenzhen, Guangdong 518055, P. R. China College of Plant Protection, Key Laboratory of Integrated Pest Management in Crops in Eastern China, Ministry of Agriculture Nanjing Agricultural University Nanjing 210095 China Department of Radiation Oncology Stephenson Oklahoma Cancer Center University of Oklahoma Health Sciences Center Oklahoma City OK USA Anhui Key Laboratory of Bioactivity of Natural Products, School of Pharmacy Anhui Medical University Hefei China; The Key Laboratory of Anti‐inflammatory and Immune Medicine, Ministry of Education Anhui Medical University Hefei China Pharmaron Beijing Co., Ltd., 6 Taihe Road, BDA, Beijing 100176, China Department of Cardiology, The Second People's Hospital of Yueqing, Yueqing, Zhejiang 325600, P.R. China College of Chemistry State Key Laboratory of Elemento‐Organic Chemistry Nankai University Tianjin 300071 P. R. China Division of Biostatistics, The University of Texas Health Science Center at Houston, Houston, USA Epstein Department of Industrial and Systems Engineering Viterbi School of Engineering University of Southern California 3715 McClintock Ave Los Angeles CA 90089‐0192 USA Department of Neurosurgery Pfizer Inc., Collegeville, PA, USA Jinling Hospital, Department of Orthopedics, Nanjing University, School of Medicine, Nanjing 210002, Jiangsu Province, P.R.China Chinese PLA Institute for Disease Control & Prevention, Academy of Military Medical Sciences, Beijing, China. 2Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, Philadelphia, Pennsylvania. Institute of Organic Chemistry; University of Vienna; 1090 Vienna; Austria Technical Institute of Physics and Chemistry Key Laboratory of Photochemical Conversion and Optoelectronic Materials 29 Zhongguancun East Road, Haidian District 100190 Beijing CHINA UTS School of Mathematical and Physical Sciences, University of Technology Sydney, Sydney, NSW, 2007, Australia. Department of Anesthesiology, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, 109 Xueyuan West Road, Wenzhou, Zhejiang 325027, China School of Environmental Science and Engineering, Huazhong University of Science and Technology, Wuhan, People’s Republic of China Department of Hepatobiliary Surgery, Xijing Hospital, Xi'an 710032, China Department of Neuroscience and Cell Biology; University of Texas Medical Branch; Galveston; Texas Ecole Normal Supérieure, CNRS-ENS-UPMC UMR 8640, 24 rue Lhomond, 75231 Paris, France; Centre for Microfluidics and Nanotechnology, Peking University, 100871 Beijing, China; Institute for Integrated Cell-Material Science, Kyoto University, Kyoto 606-8507, Japan Shenzhen Key Laboratory of Smart Healthcare Engineering, Department of Biomedical Engineering, Southern University of Science and Technology, No. 1088, Xueyuan Rd., Xili, Nanshan District, Shenzhen, Guangdong 518055, P. R. China Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States Department of Biostatistics and Epidemiology Perelman School of Medicine University of Pennsylvania Philadelphia PA MOE Key Laboratory of Cell Activities and Stress Adaptations, School of Life Sciences, Lanzhou University, Lanzhou, China University of Pennsylvania, Institute for Biomedical Informatics, Perelman School of Medicine b Division of Biostatistics , the University of Texas Health Science Centre at Houston , Houston , Texas , USA The Fourth People’s Hospital of Chengdu, Chengdu, Sichuan, China Department of Pharmaceutics, Ghent University, Ottergemsesteenweg 460, 9000 Ghemt, Belgium Department of Biostatistics, Epidemiology and Informatics University of Pennsylvania Philadelphia Pennsylvania United States of America Department of Otolaryngology–Head and Neck Surgery Fujian Provincial Hospital Provincial Clinical College of Fujian Medical University Fuzhou China Department of Paediatric Surgery, KK Women's and Children's Hospital, Singapore, Singapore Department of Musculoskeletal Oncology Fudan University Shanghai Cancer Center Shanghai China; Department of Oncology Shanghai Medical College, Fudan University Shanghai China Department of Rehabilitation Medicine, Huaihe Hospital of Henan University, Kaifeng 475000, China Department of Biological Chemistry, University of Michigan, Ann Arbor, United States; Howard Hughes Medical Institute, University of Michigan, Ann Arbor, United States Department of Orthopaedics, Jinling Hospital, Nanjing 210002, China State Key Laboratory Cultivation Base for TCM Quality and Efficacy, Nanjing University of Chinese Medicine, Nanjing 210023, China; State Key Laboratory of Pharmaceutical Biotechnology, Institute of Functional Biomolecules, Nanjing University, Nanjing 210023, China Department of Laboratory Medicine The First Affiliated Hospital of Fujian Medical University China; The Genetic Diagnostic Laboratory The First Affiliated Hospital of Fujian Medical University China; Department of Laboratory Medicine Fujian Medical University China Department of Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania. Key Laboratory of Crop Eco-Physiology and Farming System in Southwest China, Ministry of P.R. China, Wenjiang, Sichuan 611130, China; College of Agronomy, Sichuan Agricultural University, Wenjiang, Sichuan 611130, China Affiliations of authors: Service de Biostatistique et d’Epidémiologie, Gustave Roussy Cancer Campus, Villejuif, France (FR, JPP, SM, JL, PB, SM); INSERM U1018, CESP, Université Paris-Sud, Université Paris-Saclay, Villejuif, France (FR, JPP, SM, PB, SM); Ligue Nationale Contre le Cancer Meta-Analysis Platform, Gustave Roussy Cancer Campus, Villejuif, France (FR, JPP, JL, SM); Centre Hospitalier Universitaire Vaudois, Lau NHC Key Laboratory of Birth Defects for Research and Prevention, Hunan Provincial Maternal and Child Health Care Hospital, Changsha, Hunan, China; Key Laboratory of Genetics and Birth Health, Family Planning Research Institute of Hunan Province, Changsha, Hunan, China State Key Laboratory of Biotherapy, Collaborative Innovation Center of Biotherapy and Cancer Center, West China Hospital of Sichuan University, Chengdu, 610041, China; School of Chemical Engineering, Sichuan University, Chengdu, 610065, China College of Architecture and Urban Planning, Tong Ji University, Shanghai, China College of Chemistry; State Key Laboratory of Elemento-Organic Chemistry; Nankai University; P. R. China; Collaborative Innovation Center of Chemical Science and Engineering (Tianjin) Department of Pharmacy, National University of Singapore, 10 Kent Ridge Crescent, 119260, Singapore Department of Paediatric Surgery KK Women’s and Children’s Hospital Singapore Singapore State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, No. 5, Xinmofan Road, Nanjing 210009, P. R. China; College of Biotechnology and Pharmaceutical Engineering, National Engineering Technique Research Center for Biotechnology, Nanjing Tech University, No. 30, Puzhu South Road, Nanjing 211816, P. R. China Department of Oral and Maxillofacial Surgery, Institude of Stomatology, Nanjing University, Nanjing 210008, China. State Key Laboratory of Marine Resource Utilization in South China Sea; Hainan University; Haikou 570228; P. R. China; Hainan Provincial Key Laboratory of Research on Utilization of Si-Zr-Ti Resources Key Laboratory of Plant Resources Institute of Botany, Chinese Academy of Sciences Beijing 100093 China; University of Chinese Academy of Sciences Beijing 100049 China Hubei Collaborative Innovation Centre for Green Transformation of Bio-Resources School of Life Sciences Hubei University 430062 Wuhan China Emergency Department, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, P. R. China. School of Pharmacy Nantong University Nantong China Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania , Philadelphia, PA 19104, USA Department of General Surgery, Baoshan District Integrated Traditional Chinese and Western Medicine Hospital, Shanghai 201999, P.R. China Department of Chinese Medicine Sciences and Engineering Zhejiang University Hangzhou 310058 China School of Life Science and Technology University of Electronic Science and Technology of China Chengdu People's Republic of China Department of Gastroenterology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China Chemistry Department, Ecole Normale Supérieure-PSL Research University CNRS-UMR 8640, 24 Rue Lhomond, F-75005 Paris, France Department of Acupuncture, Tuina and Physical Therapy, First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325100, Zhejiang Province, China. National & Local Joint Engineering Research Center of High-throughput Drug Screening Technology; Hubei Province Key Laboratory of Biotechnology of Chinese Traditional Medicine; Hubei University; Wuhan 430062; P.R. China Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, China Wuhu Municipal Station of Endemic Diseases Control, Wuhu 241001, China. Textile Institute Sichuan University 610065 Chengdu Sichuan Province China College of Biosystems Engineering and Food Science, Zhejiang University, Beijing, China; College of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou, China Technical Institute of Physics and Chemistry & University of Chinese Academy of Sciences Beijing 100190 China Nankai University Department of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, , Tianjin 300071, People’s Republic of China Guangxi University of Chinese Medicine, Department of Pharmaceutical Analysis , Nanning 530000 , China Department of Chemical Engineering, Columbia University, 500 West 120th Street, MC4721, New York, New York 10027 Wuhan Metware Biotechnology Co., Ltd. Wuhan China grid.412022.7 0000000093895210 College of Biotechnology and Pharmaceutical Engineering Nanjing University of Technology Xin mofan Road 5 210009 Nanjing People’s Republic of China; National Engineering Technique Research Center for Biotechnology Nanjing People’s Republic of China; grid.454889.c State Key Laboratory of Motor Vehicle Biofuel Technology Nanyang People’s Republic of China Department of Radiology University of North Carolina at Chapel Hill Chapel Hill, North Carolina; Biomedical Research Imaging Center University of North Carolina at Chapel Hill Chapel Hill, North Carolina Institute of Medical Innovation and Research, Peking University Third Hospital, Beijing 100191, China; Department of Neurology, Peking University Third Hospital, Beijing 100191, China Department of Anesthesiology the Second Affiliated Hospital of Nanchang University Nanchang 330006 China Department of Urology, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China. tankcy@163.com Department of Pharmaceutics Ghent University Ghent 9000 Belgium From the Systems Biology Center (T.T.M.N., S.M., J.S., E.M.), Division of Cardiovascular Sciences (R.W.), Proteomics Core Facility (Y.C., G.W., M.G.), and Center for Molecular Medicine (M.N.S.), National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD; and Department of Pathology, Johns Hopkins Medical Center, Baltimore, MD (C.S.). Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu Department of Epidemiology Merck & Co., Inc. Kenilworth NJ USA College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China Email: chenyong6981@sina.com. Science and Technology on Reactor Fuel and Materials Laboratory, Chengdu 610041, China; Nuclear Power Institute of China, Chengdu 610041, China Institute for Pharmacology and Toxicology and Biomedical Center, University of Bonn, 53105 Bonn, Germany. College of Materials Science and Engineering, Shenzhen University, Shenzhen 518060, P. R. China École Normale Supérieure-PSL Research University; Paris; France Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA, USA School of Life Science, Lanzhou University, Lanzhou, Gansu 730000, China School of Pharmacy, Nantong University, 19 Qixiu Road, Nantong 226001, China Key Laboratory of Entomology and Pest Control Engineering, College of Plant Protection, Southwest University, Chongqing 400716, China Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania USA The First Hospital of Lanzhou University National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China; Department of Musculoskeletal Surgery Fudan University Shanghai Cancer Center Shanghai China; Department of Oncology Shanghai Medical College, Fudan University Shanghai China Key Laboratory of Plant Resources, Institute of Botany, The Innovative Academy of Seed Design, Chinese Academy of Sciences, Beijing 100093, China School of Marine Sciences University of Maine Orono Maine USA Institute for Advanced Study Nanchang University Nanchang 330031 P. R. China Pingyin Animal Husbandry and Veterinary bureau Jinan China Department of Food Science, Rutgers University, 65 Dudley Road, New Brunswick, New Jersey 08901-8520 Groupe Nanotechnologie et Dispositifs Microfluidiques, Unité Propre de Recherche 20, Laboratoire Photonique et Nanostructures, Centre National de la Recherche Scientifique, Route de Nozay, 91460 Marcoussis, France Outpatient Department of Massage, Beijing Massage Hospital, Beijing. Department of Respiratory and Critical Care Medicine, The Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan 637000, China Department of Nephrology and Hematopathology, Second Affiliated Hospital at Fengjie, Chongqing Medical University, Chongqing 404600, China Nanoscale Science and Technology Laboratory Institute for Advanced Study Nanchang University Nanchang Jiangxi People's Republic of China; College of Life Sciences Nanchang University Nanchang Jiangxi People's Republic of China Department of General Surgery, Tianjin Medical University General Hospital, Tianjin, China; Department of General Surgery, Huai’an Second People’s Hospital, Huai’an, Jiangsu, China Division of Biostatistics, The University of Texas Health Science Centre at Houston, Houston, TX, USA. University of Pennsylvania Perelman School of Medicine Philadelphia Pennsylvania; Center for Clinical Epidemiology and Biostatistics University of Pennsylvania Perelman School of Medicine Philadelphia Pennsylvania Department of Plastic Surgery, Affiliated Jinling Hospital, Medical School of Nanjing University Department of Materials Science and Engineering, State University of New York at Stony Brook, New York 11794, Harvard University, Cambridge, Massachusetts 02138, and Department of Chemistry, College of Staten Island, City University of New York, Staten Island, New York 10314 Key Laboratory of Smart Biomaterials of Zhejiang Province College of Chemical and Biological Engineering of Zhejiang University Hangzhou Zhejiang 310027 China; ZJU‐Hangzhou Global Scientific and Technological Innovation Center Hangzhou Zhejiang 311215 China Pharmaron Beijing Ltd. Co., No. 6 TaiHe Road BDA, 100176 Beijing, P. R. China Kunming National High-level Biosafety Research Center, Institute of Medical Biology, Chinese Academy of Medical Science, China CAS Key Laboratory of Bio-inspired Materials and Interfacial Science CAS Center for Excellence in Nanoscience Key Laboratory of Photochemical Conversion and Optoelectronic Materials & CAS-HKU Joint Laboratory on New Materials Technical Institute of Physics and Chemistry Chinese Academy of Sciences Beijing 100190 P. R. China; University of Chinese Academy of Sciences Beijing 100049 P. R. China Proteomics Core, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA Ecole Normale Supérieure, CNRS-ENS-UPMC UMR 8640, 24 rue Lhomond, 75005 Paris, France Department of Chemistry, École Normale Supérieure, Paris Sciences et Lettres (PSL) Research University, F-75005 Paris, France;; Sorbonne Universités, Université Pierre et Marie Curie, UMR 8640 PASTEUR, F-75005 Paris, France;; CNRS, UMR 8640 PASTEUR, F-75005 Paris, France; School of Life Sciences, Lanzhou University, Lanzhou, China School of Pharmacy; Nantong University; Nantong; China Department of Cardiology, West China Hospital, Sichuan University , Chengdu , PR China College of Chemistry, State Key Laboratory of Elemento‐Organic Chemistry Nankai University Tianjin 300071 P. R. China College of Life Science, Jilin University, Changchun, Jilin 130012, China State Key Laboratory of Marine Resource Utilization in South China Sea, Hainan Provincial Key Laboratory of Research on Utilization of Si-Zr-Ti Resources, Hainan University, Haikou, P.R. China National University of Defense Technology Institute of Space Technology, College of Aerospace Science and Engineering, , 410073 Changsha, China Department of Oral and Maxillofacial Surgery, Cangzhou Central Hospital, Cangzhou, Hebei Province, China Department of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, Peopleʼs Republic of China Institute of Space Technology, College of Aerospace Science and Engineering, National University of Defense Technology , 410073, Changsha, China Department of Chemistry, Graduate School of Science, Tohoku University, Aoba-ku, Sendai 980-8578, Japan, and PRESTO, Japan Science and Technology Agency, Sanbancho-bldg., 5-Sanbancho, Chiyodaku, Tokyo, Japan Guangzhou Institute of Energy Conversion, Chinese Academy of Sciences, Guangzhou 510640, China; School of Mechanical and Power Engineering, Nanjing Technology University, Nanjing 211816, China; Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), Guangzhou 511458, China; School of Energy Science and Engineering, University of Science and Technology of China, Hefei 230026, China Department of Sports Medicine, Research Center of Sports Medicine, Xiangya Hospital, Central South University, Changsha, China; Department of Pediatric Orthopaedics, Yongchuan Hospital, Chongqing Medical University, Chongqing, China School of Biotechnology, Jiangsu University of Science and Technology, Zhenjiang, Jiangsu, China Department of Radiology, Case Western Reserve University, Cleveland, U.S.A. Department of Psychiatry, Center for Neurobiology and Behavior, and College of Chemistry; State Key Laboratory of Elemento-Organic Chemistry; Nankai University; Tianjin 300071; P. R. China Department of Hepatobiliary Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi 710032, P.R. China Department of Molecular and Cellular Biosciences Rowan University Glassboro New Jersey USA State Key Laboratory of Food Science and Technology Nanchang University Nanchang China; Institute for Advanced Study Nanchang University Nanchang China École Normale Supérieure - PSL Research University, Département de Chimie, 24 rue Lhomond, F-75005 Paris, France; Sorbonne Universités, UPMC Univ. Paris 06, PASTEUR, F-75005 Paris, France; CNRS, UMR 8640 PASTEUR, F-75005 Paris, France Department of Acupuncture and Physiotherapy, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang Province, China. The Nanjing Han & Zaenker Cancer Institute (NHZCI), OG Pharmaceuticals, 88 Jiangdong Road, Nanjing 210036, China College of Chemistry and Chemical Engineering, Xi’an University of Science and Technology, Xi’an 710054, China College of Chemistry and Life Science, Zhejiang Normal University, Jinhua, China 321004 College of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, P. R. China Department of Laboratory Medicine Mindong Hospital of Ningde City Fuan China; Department of Laboratory Medicine Mindong Hospital Affiliated with Fujian Medical University Fuan China Department of Immunology, Bengbu Medical College, Bengbu 233003, China. College of Chemistry; State Key Laboratory of Elemento-Organic Chemistry; Nankai University; Tianjin; P. R. China Department of Musculoskeletal Oncology Fudan University Shanghai Cancer Center Shanghai 200032 P. R. China; Department of Oncology Fudan University Shanghai Medical College Shanghai 200032 P. R. China Department of Chemistry State Key Laboratory of Elemento‐Organic Chemistry Nankai University Tianjin 300071 PR China; Collaborative Innovation Center of Chemical Science and Engineering (Tianjin) Nankai University Tianjin 300071 PR China Department of Biostatistics and Epidemiology; University of Pennsylvania; PA 19104 Philadelphia U.S.A. Department of Medicine, Albert Einstein College of Medicine, Bronx, New York, USA; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA Department of Hepatobiliary Surgery, Xijing Hospital, Fourth Military Medical University, Xi’an, China Department of Biostatistics, Epidemiology and Informatics Perelman School of Medicine, University of Pennsylvania Philadelphia, PA USA Department of Surgery, Okayama University Graduate School of Medicine and Dentistry, 2-5-1 Shikata-cho, Okayama 700-8558, Japan Department of Biostatistics, Epidemiology and Informatics University of Pennsylvania Philadelphia Pennsylvania School of Pharmacy, Nantong University, Nantong, Jiangsu Province 226001, China Howard Hughes Medical Institute 1150 West, Medical Center Drive Ann Arbor Michigan 48109 USA; Department of Biological Chemistry, University of Michigan Medical School 1150 West, Medical Center Drive Ann Arbor Michigan 48109 USA Department of Medicinal Chemistry, ‡Department of Internal Medicine, §Comprehensive Cancer Center, ∥Department of Pathology, ⊥Howard Hughes Medical Institute, #Department of Biological Chemistry, ∇Department of Pharmaceutical Sciences, ○Department of Pharmacology, and ¶Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109, United States Department of Clinical Laboratory, Affiliated Changsha Hospital of University of South China, The First Hospital of Changsha City, Changsha, Hunan, China, Department of Neurosurgery, The First Hospital of Jilin University, Changchun, Jilin 130012, P.R. China Department of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, P. R. China College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China; Guangxi Key Laboratory of Natural Polymer Chemistry and Physics, Nanning Normal University, Nanning 530001, PR China Department of General Surgery, Shanghai General Hospital of Nanjing Medical University 100 Haining Road, Shanghai 200080, P. R. China. Department of General Surgery, Jiuting Hospital of Songjiang District 155 Jiuxin Road, Shanghai 201615, P. R. China. Department of Musculoskeletal Surgery of Shanghai Cancer Center, Fudan University, Dong’an Road, Shanghai 200032, China PR Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania , Philadelphia, Pennsylvania , USA Department of Musculoskeletal Oncology Fudan University Shanghai Cancer Center Shanghai People's Republic of China; Department of Oncology Shanghai Medical College of Fudan University Shanghai People's Republic of China Department of Anesthesiology The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University Wenzhou Zhejiang China Department of Surgery, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan Department of Radiation Oncology University of Oklahoma Health Sciences Center Oklahoma city OK 73104 USA Jiangsu Key Laboratory for TCM Formulae Research Nanjing 210023 P. R. China School of Civil Engineering and Architecture, Zhejiang University of Science and Technology, 318 Liuhe Road, Hangzhou 310023, China; Center of Urban and Rural Development, Zhejiang University of Science and Technology, 318 Liuhe Road, Hangzhou 310023, China College of Agronomy, South China Agricultural University, Guangzhou. chenyongcwc@tom.com The Spinal Surgery Department of The First Affiliated Hospital Of University Of South China Department of Orthopaedics, No.2 people’s hospital of Fuyang city,Yingzhou district, Fuyang city, Anhui province, 23600,China Department of Biomedical Engineering, Indiana University Purdue University at Indianapolis, Indianapolis, IN, United States Department of Bacteriology, School of Medicine The University of Tokushima Tokushima Tokushima 770 Japan Shanghai Key Lab of Intelligent Information Processing, School of Computer Science and Technology, Fudan University, Shanghai, China; Department of Neuroscience, Cell Biology and Anatomy, University of Texas Medical Branch, Galveston, TX, USA Center for Advanced Manufacturing University of Southern California Los Angeles CA 90007 USA; Daniel J. Epstein Department of Industrial and Systems Engineering University of Southern California Los Angeles CA 90089 USA; Department of Aerospace and Mechanical Engineering University of Southern California Los Angeles CA 90089 USA Institute of Basic Medical Sciences, Beijing, People's Republic of China State Key Laboratory of Chemical Resource Engineering Beijing Key Laboratory of Electrochemical Process and Technology of Materials Beijing University of Chemical Technology Beijing 10029 P. R. China Lanzhou Institute of Biological Products Company Limited Lanzhou China Department of Pathophysiology, School of Basic Medicine, Key Laboratory of Neurological Diseases, Ministry of Education and Hubei Provincial Key Laboratory of Neurological Diseases, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China Sun Yat-Sen University Cancer Center, Guangzhou, China; State Key Laboratory of Oncology in Southern China, Guangzhou, China; Collaborative Innovation Center for Cancer Medicine, Guangzhou, China College of Automation, Chongqing University of Posts and Telecommunications, Chongqing 400065, People’s Republic of China Division of Biostatistics, School of Public Health, The University of Texas Health Science Center, Houston, USA Henan University Of Engineering, Zhengzhou, Henan, 450000, P.R. China Guangzhou Institute of Energy Conversion, Chinese Academy of Sciences, Guangzhou 510640, P. R. China; Phases to Flow Laboratory, Chemical & Biological Engineering Department, Colorado School of Mines, Golden, Colorado 80401, United States Guangzhou Institute of Energy Conversion, Chinese Academy of Sciences, No. 2, Nengyuan Road, Guangzhou 510640, China; Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), Guangzhou 511458, China; CAS Key Laboratory of Renewable Energy, Guangdong Provincial Key Laboratory of New and Renewable Energy Research and Development, Guangzhou 510640, China Key Laboratory of Photochemical Conversion and Optoelectronic Materials; Technical Institute of Physics and Chemistry; Chinese Academy of Sciences; Beijing 100190; China Center of Scientific Research The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University Wenzhou PR China Department of Surgery, Okayama University Graduate School of Medicine and Dentistry, Okayama 700-8558, Japan. Key Laboratory of Analytical Chemistry for Biology and Medicine, Ministry of Education, College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, P. R. China Department of Mechanical and Aerospace Engineering and California NanoSystems Institute, University of California, Los Angeles, California 90095, Quantum Science Research, Hewlett-Packard Laboratories, 1501 Page Mill Road, Palo Alto, California 94304, and Advanced Materials Process Lab and Advanced Diagnostic Lab, Hewlett-Packard Company, Corvallis, Oregon 97330 Department of Radiation Oncology University of Oklahoma Health Sciences Center Oklahoma City OK 73104 USA Department of Neurosurgery, First Hospital of Jilin University, Changchun, China Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA; Case Center for Imaging Research, Case Western Reserve University, Cleveland, OH, USA †CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China; Flexible Display Mater. & Tech. Co-Innovation Center of Hubei; Institute for Interdisciplinary Research; Jianghan University; Wuhan 430056, PR China; Key Laboratory of Optoelectronic Chemical Materials and Devices of Ministry of Education Department of Medical Oncology, Northern Jiangsu People's Hospital, Clinical Medical College of Yangzhou University, Yangzhou, Jiangsu, China Key Laboratory of Photochemical Conversion and Optoelectronic Materials Technical Institute of Physics and Chemistry Chinese Academy of Sciences Beijing 100190 P. R. China Central Hospital Affiliated to Shenyang Medical College, 5 South 7th West Rd, Shenyang, Liaoning 110024, China Pfizer, New York City, NY. School of Chemistry and Environmental Engineering; Key Laboratory of Green Chemical Process of Ministry of Education; Wuhan Institute of Technology; Wuhan 430074; P. R. China Key Laboratory of Photochemical Conversion and Optoelectronic Materials and HKU-CAS Joint Laboratory on New Materials; Technical Institute of Physics and Chemistry and University of Chinese Academy of Sciences; CAS; Beijing; People's Republic of China College of Life Sciences, Key Laboratory of Agricultural Environmental Microbiology of Ministry of Agriculture, Nanjing Agricultural University, Nanjing 210095, China Division of Gastroenterology and Hepatology Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, State Key Laboratory for Oncogenes and Related Genes; Shanghai Institute of Digestive Disease; Renji Hospital, School of Medicine, Shanghai Jiao Tong University Shanghai China Department of Pathology, Anhui Province Maternity and Child Health Hospital Anhui Medical University Hefei China University of Vienna, Faculty of Chemistry, Institute of Organic Chemistry, Währinger Straße 38, 1090 Vienna, Austria Department of Obstetrics and Gynecology, Southwest Hospital, Third Military Medical University, Chongqing 400038, China. Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA Department of Urology Institute of Medical Laboratory Sciences, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, China Tianjin Medical University Cancer Institute and Hospital Huanhu Xi road, Hexi district 300060 Tianjin China State Key Laboratory of Molecular Biology, National Center for Protein Science Shanghai, Shanghai Science Research Center, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences; University of Chinese Academy of Sciences, 333 Haike Road, Shanghai 201210, China; School of Life Science and Technology, Shanghai Tech University, 100 Haike Road, Shanghai 201210, P.R. China Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania 210 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104-6021, USA Division of Biostatistics; University of Texas School of Public Health; 1200 Pressler St, Houston, Texas 77030 U.S.A. Proteomics Core Facility, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892; State Key Laboratory of Biotherapy and Cancer Center, National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University, Chengdu 610041, Sichuan, China Department of Food Science and Department of Plant Sciences, Cook College, Rutgers University, 65 Dudley Road, New Brunswick, New Jersey 08901-8520 School of Life Sciences, Hubei Province Key Laboratory of Biotechnology of Chinese Traditional Medicine, National & Local Joint Engineering Research Center of High-throughput Drug Screening Technology, Hubei University, Wuhan 430062, China College of Chemistry; Fuzhou University; China Department of Biostatistics, Epidemiology and Informatics, the Perelman School of Medicine, University of Pennsylvania Institute of High Energy Physics, Chinese Academy of Sciences , 100049 Beijing, China College of Life Sciences, Key Laboratory for Microbiological Engineering of Agricultural Environment of Ministry of Agriculture, Nanjing Agricultural University, Nanjing 210095, People’s Republic of China Department of Neurosurgery, The First Hospital of Jilin University, Changchun, China; Clinical College, Jilin University, Changchun, China Department of Psychiatry and Pharmacology, Center for Neurobiology and Behavior (S.B., Y.C., S.F.K.); and Department of Medicine, Division of Endocrinology, Diabetes, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania 19104 Key Laboratory of Photochemical Conversion and Optoelectronic Materials and HKU-CAS Joint Laboratory on New Materials; Technical Institute of Physics and Chemistry; Chinese Academy of Sciences; Beijing 100190; P. R. China Laboratory of Animal Nutrition College of Animal Science Xinjiang Agricultural University Urumqi China Department of Anesthesiology Shanghai Pulmonary Hospital Tongji University School of Medicine Shanghai China School of Chemical and Environmental Engineering; Shanghai Institute of Technology; Shanghai 201418; China Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, Philadelphia, Pennsylvania, USA Institute of Organic Chemistry, University of Vienna, Währinger Strasse 38, 1090 Vienna, Austria Division of Rheumatology, Department of Internal Medicine, Jianyang People's Hospital, Sichuan, China. Key Laboratory of Photochemical Conversion and Optoelectronic Materials and HKU-CAS Joint Laboratory on New Materials, Technical Institute of Physics and Chemistry and University of Chinese Academy of Sciences (CAS), Beijing 100190, People’s Republic of China Key Laboratory of Smart Biomaterials of Zhejiang Province, College of Chemical and Biological Engineering, ZJU-Hangzhou Global Scientific and Technological Innovation Center, Zhejiang University, Hangzhou, Zhejiang 310027, China Medical Center of Burn Plastic and Wound Repair, The First Affiliated Hospital of Nanchang University , Nanchang 330006 , China Department of Agronomy, Quartermaster University of PLA, Changchun 130062, China. chygg@yahoo.com Department of Chemistry, Institute for Proteomics Technology and Applications, The George Washington University, Washington, D.C. 20052, and Center for Mass Spectrometry, The Department of Molecular Biology, The Scripps Research Institute, La Jolla, California 92037 1 MOE Key Laboratory of Bioinformatics and Bioinformatics Division, TNLIST/Department of Automation, Tsinghua University, Beijing 1000084, 2Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China, 3School of Sciences, University of Jinan, Jinan 250022, China and 4Department of Computer Science and Engineering, University of California, Riverside, CA 92521, USA; 1 MOE Key Laboratory of Bioinformatics and Bioinformatics Division, TNLIST/Department of Automation, Tsinghua University, Beijing 1000084, 2Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China, 3School of Sciences, University of Jinan, Jinan 250022, China and 4Department of Computer Science and Engineering, University of California, Riverside, CA 92521, USA; 1 MOE Key Laboratory of Bioinformatics and Bioinformatics Division, TNLIST/Department of Automation, Tsinghua University, Beijing 1000084, 2Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China, 3School of Sciences, University of Jinan, Jinan 250022, China and 4Department of Computer Science and Engineering, University of California, Riverside, CA 92521, USA Department of Chemistry and Biochemistry, The Ohio State University, Columbus, Ohio 43210, United States Department of Chemistry, University of Waterloo, Ontario N2L 3G1, Canada Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, Philadelphia, Pennsylvania 19104, U.S.A College of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Nankai 300071, China Key Laboratory of Photochemical Conversion and Optoelectronic Materials; Technical Institute of Physics and Chemistry; Chinese Academy of Sciences; Beijing 100190; P. R. China College of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Nankai University, 94 Weijin Road, Nankai District, Tianjin 300071, P. R. China Department of Chemistry, University of Waterloo, Waterloo, Ontario, Canada N2L 3G1 Wuhan Huoshenshan Hospital Wuhan China; Chinese PLA Center for Disease Control and Prevention Beijing China Pharmacoepidemiology Department, Merck & Co., Inc., Kenilworth, New Jersey School of Metallurgy and Materials Engineering; Chongqing University of Science and Technology; Chongqing 400050; P. R. China Institute for Applied and Environmental Microbiology, College of Life Science, Inner Mongolia Agricultural University, Huhhot 010018, PR China National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100005, China, Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota 55905, Lanzhou Institute of Biological Products (LIBP), The China National Biotech Group (CNBG), Lanzhou University, Lanzhou, 730046, China, and Department of Molecular Parasitology, Humboldt University, Philippstrasse 13, House 14, Berlin,... Department of Pharmaceutics, Ghent University, Ghent 9000, Belgium Department of Anesthesia, The Third People’s Hospital of Chengdu, Chengdu, Sichuan, China (mainland) Guangzhou Institute of Forestry and Landscape Architecture, Guangzhou 510405, China Center for Microfluidics and Nanotechnology, Peking University, 100871 Beijing, PR China, School of Physics, Peking University, 100871 Beijing, PR China, and Ecole Normale Suéprieure, 24 rue Lhomond, 75231 Paris, France Department of Radiology, General Hospital of Ningxia Medical University, Yinchuan, China. Diabetes Center, University of California, San Francisco, San Francisco, CA 94143, USA.; Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, San Francisco, CA 94143, USA.; Department of Cell and Tissue Biology, University of California, San Francisco, San Francisco, CA 94143, USA. California NanoSystems Institute, ‡Department of Microbiology, Immunology & Molecular Genetics, and §Department of Biomedical Engineering, University of California, Los Angeles, Los Angeles, California 90095, United States Department of Neurosurgery, First Hospital of Jilin University, Changchun, P. R. China Laboratory of Natural and Targeted Small Molecule Drugs, State Key Laboratory of Biotherapy and Cancer Center, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu 610041, China Kunshan Hospital of Traditional Chinese Medicine, Kunshan 215300, China Key laboratory for Thermal Science and Power Engineering of Ministry of Education, Thermal Engineering Department, Tsinghua University, Beijing 100084, China. yong-chen03@mails.tsinghua.edu.cn Division of Biostatistics, The University of Texas Health Science Center at Houston, 1200 Pressler St, Houston, TX 77030, USA, yong.chen@uth.tmc.edu , URL: https://sph.uth.tmc.edu/cv/Yong2011.pdf. Department Department of Minimally Invasive Gastrointestinal Surgery,Second Xiangya Hospital,Central South University, Changsha 410011,China. zndxxyeyy@126.com. Department of Musculoskeletal Surgery, Shanghai Medical College Fudan University Shanghai Cancer Shanghai China Fujian Key Laboratory for Monitoring and Integrated Management of Crop Pests, Institute of Plant Protection, Fujian Academy of Agricultural Sciences, Fuzhou, China; State Key Laboratory of Ecological Pest Control for Fujian and Taiwan Crops, Fujian-Taiwan Joint Centre for Ecological Control of Crop Pests, Fujian Agriculture and Forestry University, Fuzhou, China; Fuzhou Scientific Observing and Experimental Station of Crop Pests of Ministry of Agriculture, Fuzhou, China CNRS UMR Pasteur 8640, Ecole Normale Supérieure, 24 rue Lhomond, 75231 Paris Cedex 05, France Clinical Medical School of Yangzhou University, Subei People's Hospital of Jiangsu Province, Yangzhou, Jiangsu 225001, P.R. China Department of Clinical Laboratory, Affiliated Nanjing Brain Hospital, Nanjing Medical University, Nanjing, Jiangsu Province, China University of Southern California Radiology, University Hospitals Case Medical Center; Cleveland Ohio USA Signal Transduction Laboratory, Institute of Molecular and Cell Biology College of Life Science and Technology, Jinan University, Guangzhou 510632, China. Department of Mechanical and Aerospace Engineering, California NanoSystems Institute, University of California, Los Angeles, California 90095 China Institute of Veterinary Drug Control, Beijing 100081, China Department of Biochemistry, Biophysics, and Molecular Biology, Iowa State University, Ames, Iowa 50011 Department of Biomedical Engineering, School of Engineering, and Department of Stomatology, School of Medicine, Xiamen University, Xiamen, China Department of Clinical Pharmacology The Second Hospital of Anhui Medical University Hefei China College of Agriculture and Biotechnology, Hunan University of Humanities, Science and Technology, Loudi 417000, China School of Marine Science, University of Maine, Orono, ME 04469; From the Departments of Medicine (W.L., A.L., H.M.L., B.J.B.), Pathology (Y.C., W.B. III, R.H.H., P.M., B.J.B.), and Surgery (J.H.B., A.D.), Johns Hopkins University School of Medicine, Baltimore, Md.; Department of Medicine (B.J.B.), Albert Einstein College of Medicine, Bronx, NY; and Genetic Therapy Inc. (A Novartis Company) (J.M.-N., S.C.S.), Gaithersburg, Md. State Key Laboratory of Marine Resource Utilization in South China Sea, College of Materials and Chemical Engineering, Hainan University, Haikou 570228, PR China Department of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Collaborative Innovation Center of Chemical Science and Engineering and ‡Department of Biochemistry and Molecular Biology, College of Life Sciences, Nankai University, Tianjin 300071, P. R. China Department of Biomedical Engineering; Southern University of Science and Technology; Shenzhen; China Department of Biostatistics and Epidemiology The University of Pennsylvania Philadelphia Pennsylvania; Institute for Biomedical Informatics The University of Pennsylvania Philadelphia Pennsylvania; Center for Evidence-based Practice The University of Pennsylvania Philadelphia Pennsylvania; Applied Mathematics and Computational Science The University of Pennsylvania Philadelphia Pennsylvania; School of Arts and Sciences The University of Pennsylvania Philadelphia Pennsylvania Perelman School of Medicine, The University of Pennsylvania, Philadelphia Epstein Department of Industrial and Systems Engineering, Viterbi School of Engineering, University of Southern California, Los Angeles, California 90089, United States; Department of Aerospace and Mechanical Engineering, Viterbi School of Engineering, University of Southern California, Los Angeles, California 90089, United States Jiangxi Key Laboratory for Microscale Interdisciplinary Study, Institute for Advanced Study, Nanchang University, Nanchang 330031, China Department of Biostatistics, Epidemiology, and Informatics University of Pennsylvania Philadelphia Pennsylvania USA Department of Chemistry, Nankai University, Tianjin, 300071, China, and ERATO (JST), Department of Molecular Chemistry, Osaka University, 2-1 Yamadaoka, Suita 565-0871, Japan yuliu@public.tpt.tj.cn Energy Technology Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Umezono, 1-1-1, Tsukuba, 305-8568, Japan University of Massachusetts Medical School, Division of Geriatric Medicine, Worcester, MA 01605, USA. yong.chen@umassmed.edu Department of Emergency, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong 250021, P.R. China Medical Oncology Department of Orthopedics, Jinling Hospital, Nanjing University School of Medicine, Nanjing 210002, China Department of Anesthesiology, Yale University School of Medicine, New Haven, Connecticut 06510 School of Chemical and Environmental Engineering, Shanghai Institute of Technology, Shanghai 201418, China *Division of Allergy and Immunology, Department of Pediatrics, Duke University Medical Center, Durham, NC 27710;; †School of Laboratory Medicine, Wenzhou Medical College, Wenzhou, Zhejiang 325035, China; Department of Acupuncture, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China Department of Mechanical and Aerospace Engineering, University of California, Los Angeles, California 90095, United States School of Information, Zhejiang University of Finance and Economics, Hangzhou 310018, China. Department of Life Sciences, Hunan University of Humanities, Science and Technology, Loudi, China; Collaborative Innovation Center for Farmland Weeds Control, Hunan University of Humanities, Science and Technology, Loudi, China Department of Surgery, Okayama University Graduate School of Medicine and Dentistry, Okayama 700-8558, Japan College of Mechanical and Electronic Engineering, Nanjing Forestry University Nanjing Jiangsu China School of Petroleum Engineering, China University of Petroleum (East China), Qingdao 266580, China Department of Gastroenterology, Yancheng Hospital of Traditional Chinese Medicine affiliated to Nanjing University of Chinese Medicine, Yancheng 224001, China Department of Laboratory Medicine, Mindong Hospital, Fujian Medical University, Fuan, China Institute of Plant Protection, Fujian Academy of Agricultural Sciences, Fuzhou, China; Fujian Key Laboratory for Monitoring and Integrated Management of Crop Pests, Fuzhou, China; Fuzhou Scientific Observing and Experimental Station of Crop Pests of Ministry of Agriculture, Fuzhou, China Research Center For Nanosensor Molecular Diagnostic & Treatment Technology, College of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen 518060, Guangdong, P. R. China; Graphene Composite Research Center, College of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen 518060, Guangdong, P. R. China College of Chemistry, State Key Laboratory of Elemento-Organic Chemistry Nankai University Tianjin 300071 P.R. China Department of Chemistry, Ecole Normale Supérieure, 24 rue Lhomond, 75005 Paris, France State Key Laboratory of Materials‐Oriented Chemical Engineering Nanjing Tech University No. 5, Xinmofan Road Nanjing 210009 China; College of Biotechnology and Pharmaceutical Engineering National Engineering Technique Research Center for Biotechnology Nanjing Tech University No. 30, Puzhu South Road Nanjing 211816 China Division of Gastroenterology and Hepatology,Key Laboratory of Gastroenterology and Hepatology,Ministry of Health,State Key Laboratory for Oncogenes and Related Genes,Renji Hospital,School of Medicine,Shanghai Jiao Tong University,Shanghai Institute of Digestive Disease,Shanghai,China School of Stomatology and MedicineFoshan University Foshan China Institute of Chemical Defence, Academy of Military Sciences, Zhijiang, Hubei 443200, China College of Petrochemical Engineering and Environment, Zhejiang Ocean University, No. 1, Haida South Road, Dinghai District, Zhoushan 316022, Zhejiang, P. R. China China Mobile Laboratory Response Team for Ebola in Sierra Leone, Freetown, Sierra Leone Department of Clinical Laboratory Changsha First Hospital Changsha Hunan China Department of Respiratory Medicine and Department of Chemistry, Paris Sciences et Lettres, Ecole Normale Supérieure de Paris CNRS UMR, Paris, France Orthopedic Center, Kunshan Hospital of Traditional Chinese Medicine, Suzhou, Jiangsu 215300, P.R. China Technical Institute of Physics and Chemistry & University of Chinese Academy of Sciences Beijing 100190 P. R. China Department of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, People’s Republic of China *SEQUENOM, Inc., 3595 John Hopkins Court, San Diego, CA 92121; and for the CASE Investigators Fujian Engineering Research Center for Green Pest Management, Fujian Key Laboratory for Monitoring and Integrated Management of Crop Pests, Institute of Plant Protection, Fujian Academy of Agricultural Sciences , Fuzhou , China; Fuzhou Scientific Observing and Experimental Station of Crop Pests of Ministry of Agriculture and Rural Affairs , Fujian , China School of Mechanical Engineering, Nanjing Institute of Industry Technology, Nanjing 210023, China Xishan Forest Farm, Dazu District , Chongqing 402360 , China Department of Oncology, Central Hospital of Shaoyang, Shaoyan, China Collaborative Innovation Center for Distant‐Water Fisheries Shanghai 201306 China; School of Marine Sciences University of Maine Orono ME 04469 U.S.A. Pharmaron Beijing Co. Ltd., No. 6 Tai He Road, BDA, 100176, Beijing, China College of Mechanical and Electronic Engineering Nanjing Forestry University Nanjing China School of Metallurgy and Materials Engineering, Chongqing University of Science and Technology, Chongqing 401331, China Department of Pediatric Surgery, KK Women's and Children's Hospital, Singapore College of Chemistry State Key Laboratory of Elemento-Organic Chemistry Nankai University Tianjin 300071 P. R. China Department of General Surgery, The Second Xiangya Hospital of Central South University, Changsha 410011, China Department of Neuroscience and Cell Biology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555-1069, USA Viterbi School of Engineering, University of Southern California, Los Angeles, California, USA College of Advanced Materials Engineering, Jiaxing Nanhu University, Jiaxing 314001, China *Division of Allergy and Immunology, Department of Pediatrics, Duke University Medical Center, Durham, NC 27710;; †School of Laboratory Medicine, Wenzhou Medical College, Wenzhou, Zhejiang 325035, China; and Department of Radiotherapy, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. poor9927@126.com Department of Biostatistics and Epidemiology The University of Pennsylvania Philadelphia Pennsylvania Pharmaceutical Institute, Nanjing University of Chinese Medicine, Nanjing 210023, P. R. China Hubei Provincial Key Laboratory of Traditional Chinese Medicine and Biotechnology, Faculty of Life Science, Hubei University, Wuhan 430062, China. cy101610@npc.gov.cn Department of Neurology, Ningbo Medical Center Lihuili Hospital, Ningbo, China Department of Biological Sciences, Center for Systems Biology, University of Texas at Dallas Richardson Texas Stroke Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892; Resuscitative Medicine Department, Naval Medical Research Center, Silver Spring, MD 20910; and Department of Neurology, University of Washington, Seattle, WA 98195 Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, No. 197, Ruijin Er Rd, Shanghai 200025, China. Research Center of Experimental Acupuncture Science, Tianjin University of Traditional Chinese Medicine, Tianjin, China Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA Department of Medical Oncology, Subei People's Hospital Yangzhou, Jiangsu 225000, China. Department of Pharmacy Fuzhou Children's Hospital of Fujian Medical University Fuzhou 350005 People's Republic of China Department of Function Examination, Clinical Medical College, Yangzhou University, Yangzhou, Jiangsu 225000, P.R. China Department of Biostatistics, Epidemiology and Informatics University of Pennsylvania Philadelphia Pennsylvania USA Key Laboratory of Epigenetic Regulation and Intervention, State Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China; Key Laboratory of Systems Health Science of Zhejiang Province, School of Life Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310024, China Key Laboratory of Photochemical Conversion and Optoelectronic Materials and HKU-CAS Joint Laboratory on New Materials, Technical Institute of Physics and Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Beijing 100190, P. R. China Key Laboratory of Molecule Synthesis and Function Discovery (Fujian Province University) State Key Laboratory of Photocatalysis on Energy and Environment College of Chemistry Fuzhou University Fuzhou 350108 China MilliporeSigma, 595 N. Harrison Road, Bellefonte, Pennsylvania 16823, United States Key Laboratory of Genetics and Birth Health of Hunan Province, Family Planning Institute of Hunan Province, Changsha, China Department of Chemistry, Nankai University, Tianjin, 300071, China, Inoue Photochirogenesis Project, ERATO, JST, 4-6-3 Kamishinden, Toyonaka 565-0085, Japan, and Department of Molecular Chemistry, Osaka University, 2-1 Yamadaoka, Suita 565-0871, Japan Division of Biostatistics School of Public Health, The University of Texas Health Science Center at Houston TX Department of Orthopedics, Center Hospital Affiliated to Shenyang Medical College, Shenyang, Liaoning 110024, P.R. China Department of Mechanical and Aerospace Engineering, and California NanoSystems Institute, University of California, Los Angeles, California 90095, United States 1State Key Laboratory of Oncology in Southern China;; 3Department of Radiation Oncology, Cancer Center, and Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania (YC,AEC) Department of Pathology, Anhui Province Maternal and Child Health Hospital Hefei, Anhui Province, China. Institute for Interdisciplinary Research; Jianghan University; Wuhan 430056; P. R. China; Département de Chimie Center for Pharmacoepidemiology Research and Training Perelman School of Medicine at the University of Pennsylvania Philadelphia Pennsylvania USA; Center for Clinical Epidemiology and Biostatistics Perelman School of Medicine at the University of Pennsylvania Philadelphia Pennsylvania USA; Department of Biostatistics, Epidemiology, and Informatics Perelman School of Medicine at the University of Pennsylvania Philadelphia Pennsylvania USA; Institute for Biomedical Informatics at the University of Pennsylvania Philadelphia Pennsylvania USA; Center for Evidence‐based Practice at the University of Pennsylvania Philadelphia Pennsylvania USA 3Department of Hepatobiliary Surgery, First Affiliated Hospital, Chongqing Medical University, Chongqing, China. Department of Neurosurgery, First Hospital, Jilin University, Changchun, Jilin 130021, China Department of Mechanical and Industrial Engineering, Northeastern University, Boston, Massachusetts 02115, United States Department of Cardiothoracic Surgery; Children's Hospital of Nanjing Medical University; Nanjing China State Key Laboratory of Marine Resource Utilization in South China Sea, Hainan Provincial Key Laboratory of Research on Utilization of Si-Zr-Ti Resources, Hainan University, 58 Renmin Road, Haikou 570228, China Department of Anesthesiology, Second Affiliated Hospital of Nanchang University Department of Pharmacoepidemiology, Merck & Co., Inc. Kenilworth New Jersey; Department of Patient & Health Impact, Pfizer Inc. Collegeville Pennsylvania College of Life Sciences Key Laboratory of Agricultural Environmental Microbiology of Ministry of Agriculture Nanjing Agricultural University Nanjing 210095 China Department of Chemistry State Key Laboratory of Elemento-Organic Chemistry Nankai University Tianjin 300071 P. R. China State Key Laboratory of Plant Diversity and Specialty Crops, Institute of Botany Chinese Academy of Sciences Beijing China; China National Botanical Garden Beijing China Department of Neurology Huaihe Hospital of Henan University Kaifeng China CAS Key Laboratory of Bio‐inspired Materials and Interfacial Science CAS Center for Excellence in Nanoscience Key Laboratory of Photochemical Conversion and Optoelectronic Materials & CAS‐HKU Joint Laboratory on New Materials Technical Institute of Physics and Chemistry Chinese Academy of Sciences Beijing 100190 P. R. China; University of Chinese Academy of Sciences Beijing 100049 P. R. China Nanchang Hongdu Hospital of Traditional Chinese Medicine Institute of Biomechanics, School of Bioscience & Bioengineering, South China University of Technology, Guangzhou 510006, P.R.China. Department of Clinical Medicine, Weifang Medical University Department of Immunology, Bengbu Medical College, and Anhui Key Laboratory of Infection and Immunity at Bengbu Medical College Shanghai Chest Hospital, China Division of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, State Key Laboratory for Oncogenes and Related Genes, Renji Hospital, School of Medicine Shanghai Jiao Tong University; Shanghai Institute of Digestive Disease Shanghai China National & Local Joint Engineering Research Center of High-throughput Drug Screening Technology, Hubei Key Laboratory of Biotechnology of Chinese Traditional Medicine, School of Life Sciences, Hubei University, Wuhan 430062, China Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA. Pfizer Inc, Collegeville, PA, USA Division of Biostatistics, School of Public Health The University of Texas Houston Texas United States of America Laboratory of Food Oral Processing, School of Food Science & Biotechnology, Zhejiang Gongshang University, Hangzhou, Zhejiang, China Proteomics Core Facility, and State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, No. 5 Xinmofan Road, Nanjing 210009, China Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania , Philadelphia, Pennsylvania, USA Department of Plastic Surgery, School of Medicine, Jinling Hospital, Nanjing University, Nanjing, Jiangsu, China Institute for Interdisciplinary Research & Key Laboratory of Optoelectronic Chemical Materials and Devices of Ministry of Education, Jianghan University, Wuhan 430056, China; Département de Chimie, Ecole Normale Supérieure, 24 Rue Lhomond, F-75231 Paris Cedex 05, France State Key Laboratory of Materials-Oriented Chemical Engineering, College of Life Science and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, China; National Engineering Technique Research Center for Biotechnology, Nanjing Tech University, Nanjing, China Key Laboratory of Photochemical Conversion and Optoelectronic Materials & CAS-HKU Joint Laboratory on New Materials Technical Institute of Physics and Chemistry Chinese Academy of Sciences Beijing 100190 P. R. China College of Chemistry and Materials Science, Sichuan Normal University, Chengdu 610066, P. R. China Orthopedic Center Kunshan Hospital of Traditional Chinese Medicine Kunshan China College of Chemistry State Key Laboratory of Elemento‐Organic Chemistry Nankai University Tianjin 300071 P. R. China; Collaborative Innovation Center of Chemical Science and Engineering (Tianjin) Tianjin 300071 P. R. China Department of Radiation Oncology, Peggy and Charles Stephenson Cancer Center, The University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA College of Life Sciences, Nanchang University; Nanoscale Science and Technology Laboratory, Institute for Advanced Study, Nanchang University School of Environmental Science and Engineering, Huazhong Univ. of Science and Technology Wuhan 430074 China National Institute of Neurological Disorders and Stroke, Stroke Branch, National Institutes of Health, Bethesda, Maryland, U.S.A. University of Texas School of Public Health , Houston, USA Biostatistics and Epidemiology, The University of Pennsylvania, Philadelphia, PA, USA Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, ETH Zürich, Zürich, Switzerland Translational Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada; Division of General and Thoracic Surgery, The Hospital for Sick Children, Toronto, Ontario, Canada; Department of Pediatric Surgery, KK Women's and Children's Hospital, Singapore Perelman School of Medicine, Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, Philadelphia Department of Basic Medicine, Key Lab for Immunology in Universities of Shandong Province, Immunology Lab, Weifang Medical University, Weifang, Shandong 261053, P.R. China Key Laboratory of Plant Resources, Institute of Botany, The Innovative Academy of Seed Design Chinese Academy of Sciences Beijing China Department of Radiation Oncology, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai School of Integrated Traditional Chinese and Western Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian 350122, P.R. China State Key Laboratory on Marine Resource Utilization in South China Sea, Hainan Provincial Key Laboratory of Research on Utilization of Si−Zr−Ti Resources, Materials and Chemical Engineering, Hainan University, 58 Renmin Road, Haikou 570228, China; Key Laboratory of Advanced Energy Materials Chemistry (Ministry of Education), Nankai University, Tianjin 300071, China College of Architecture and Urban Planning, Tongji University, Shanghai, China Ningbo Beilun Third People’s Hospital, Ningbo, China Department of Biomedical Engineering, Purdue School of Engineering and Technology Indiana University‐Purdue University at Indianapolis Indianapolis Indiana USA; Department of Materials Science Jinchu University Hubei China Department of Food Science, Cook College, Rutgers, The State University of New Jersey, 65 Dudley Road, New Brunswick, New Jersey 08901-8520 Xijing Hospital of Fourth Military Medical University, 15 West Changle Road, Xi’an 710032, China Department of Musculoskeletal Surgery Fudan University Shanghai Cancer Center Shanghai China; Department of Oncology, Shanghai Medical College Fudan University Shanghai China Stroke Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland School of Metallurgy and Materials Engineering Chongqing University of Science and Technology Chongqing 401331 P. R. China Division of Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA Thoracic Surgery Department, The Second Neijiang People's Hospital, Sichaun, P.R. China College of Pharmaceutical Sciences Zhejiang University 338 Yuhangtang Road Hangzhou 310058 China Department of Radiation Oncology, The First Affiliated Hospital, Sun Yat‐sen University, Guangzhou, China State Key Laboratory of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, P. R. China; Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin 300072, P. R. China Institute for Integrated Cell‐Material Sciences (WPI‐iCeMS) Kyoto University Kyoto 6068501 Japan; Ecole Normale Supérieure CNRS‐ENS‐UPMC UMR 8640 24 Rue L'homond Paris 75005 France Institute of Disease Control and Prevention, Academy of Military Medical Sciences, Beijing, China Chinese Academy of Sciences; University of Science and Technology of China The Second Hospital of Shanxi Medical University Taiyuan China Meyers Primary Care Institute, University of Massachusetts Medical School, Worcester, 01605, USA. Department of Industrial and Systems Engineering, The University of Iowa College of Engineering Iowa City Iowa USA State Key Laboratory of Fine Chemicals, School of Environmental Science and Technology Dalian University of Technology Dalian 116024 P. R. China Department of Plastic and Reconstructive Surgery of Baogang Hospital, Second Medical University, Shanghai 201900, China. Proteomics Core, National Heart, Lung and Blood Institute, NIH, Bethesda, MD 20892, USA Hubei Provincial Key Laboratory of Traditional Chinese Medicine and Biotechnology, School of Life Science, Hubei University, Wuhan 430062, Hubei Province, China. cy101610@npc.gov.cn University of Pennsylvania Department of Radiology Case Western Reserve Universityand University Hospitals Cleveland Medical Center Cleveland Ohio Department of Human Anatomy and Histology and Embryology, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, Fujian Province, PR China Key Laboratory of Photochemical Conversion and Optoelectronic Materials HKU-CAS Joint Laboratory on New Material Technical Institute of Physics and Chemistry Chinese Academy of Sciences Beijing 100190 P.R. China Department of Biostatistics and Epidemiology, The University of Pennsylvania, Philadelphia, PA 19104, USA State Key Laboratory of Photocatalysis on Energy and Environment; and Key Laboratory of Molecule Synthesis and Function Discovery; College of Chemistry; Fuzhou University; China Department of Oncology, Affiliated Hospital of Yangzhou University, Jiangsu, China. Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia College of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Nankai University; Tianjin 300071; P. R. China Department of Neurology, University of Würzburg, Josef-Schneider-Str 11, 97080 Würzburg, Germany Department of Radiation Oncology University of Oklahoma Health Sciences Center Oklahoma City Oklahoma USA Department of Hepatobiliary Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China. Department of Biostatistics and Epidemiology University of Pennsylvania Philadelphia PA 19104 U.S.A. Albert Einstein College of Medicine Bronx New York USA Oncology Department Northern Jiangsu People's Hospital and Clinical Medical College of Yangzhou University Yangzhou China Department of Chemistry, Ecole Normale Supérieure Paris France The People’s Hospital of the Tibet Autonomous Region, Lhasa 850000, China. State Key Laboratory of Marine Resource Utilization in South China Sea, Hainan University, 58 Renmin Road, Haikou 570228, China Department of Biomedical Engineering Washington University in St. Louis, St. Louis, MO 63130 Department of Radiology Case Western Reserve University Cleveland Ohio USA Hubei Provincial Key Laboratory of Biotechnology of Traditional Chinese Medicine, Hubei University, Wuhan. Division of Gastrointestinal Surgery, Department of General Surgery, The Affiliated Huai’an Hospital of Xuzhou Medical University, Huai’an, China Division of in vitro Diagnostics Shenzhen Mindray Bio‐Medical Electronics Corporation Shenzhen China Guangzhou Institute of Energy Conversion, Chinese Academy of Sciences, Guangzhou 510640, China; Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), Guangzhou 511458, China; CAS Key Laboratory of Renewable Energy, Guangdong Provincial Key Laboratory of New and Renewable Energy Research and Development, Guangzhou 510640, China Laboratory for Drug Delivery & Translational Medicine, School of Pharmacy, Nantong University, 19 Qixiu Road, Nantong 226001, China State Key Laboratory of Biotherapy and Cancer Center, National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University, Chengdu 610041, China Department of Anesthesiology The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University Wenzhou China Department of Hepatobiliary Surgery, Xijing Hospital, Fourth Military Medical University, Shaanxi, China Division of Vascular and Interventional Radiology, Department of General Surgery, Nanfang Hospital, Southern Medical University, 1838 North Guangzhou Avenue, Guangzhou, 510515, P.R. China Guangdong Key Laboratory of Animal Conservation and Resource Utilization, Guangdong Public Laboratory of Wild Animal Conservation and Utilization, Institute of Zoology Guangdong Academy of Sciences Guangzhou China University of Electronic Science and Technology of China 1 School of Energy Science and Engineering, , Chengdu 611731, China; University of Adelaide 2 School of Mechanical Engineering, , SA 5005, Australia Department Department of Chemistry State Key Laboratory of Elemento-Organic Chemistry Nankai University Tianjin 300071 P.R. China; Collaborative Innovation Center of Chemical Science and Engineering Nankai University Tianjin 300071 P.R. China Department of Anesthesiology The Second Affiliated Hospital of Nanchang University Nanchang China College of Chemistry; State Key Laboratory of Elemento-Organic Chemistry; Nankai University; Tianjin; China Department of Orthopaedics, Jinling Hospital, Nanjing, China College of Petrochemical Engineering and Environment, Zhejiang Ocean University, No. 1, Haida South Road, Dinghai District, Zhoushan, Zhejiang 316022, P. R. China University of Pennsylvania, Philadelphia, PA. Department of Microbiology and Immunology, Center for Primate Biomedical Research, University of Illinois College of Medicine, Chicago; Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, P. R. China State Key Laboratory of Chemical Resource Engineering Beijing Key Laboratory of Electrochemical Process and Technology of Materials Beijing University of Chemical Technology Beijing 10029 P. R. China; School of Chemical & Environmental Engineering China University of Mining & Technology Beijing 100083 P. R. China Department of Radiology UH Cleveland Medical Center Cleveland Ohio Guangdong Key Laboratory of Animal Conservation and Resource Utilization, Guangdong Public Laboratory of Wild Animal Conservation and Utilization Institute of Zoology, Guangdong Academy of Sciences Guangzhou China Department of Medical Oncology, Northern Jiangsu People’s Hospital, Yangzhou, China Hubei Province Key Laboratory of Biotechnology of Chinese Traditional Medicine, Hubei University, 430062, P. R. China Department of Cardiology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250021, P.R. China Department of Pharmaceutics Ghent University, Belgium Ottergemsesteenweg 460 Gent 9000 Belgium Department of Mechanical and Aerospace Engineering and the California NanoSystems Institute, University of California, Los Angeles, 420 Westwood Plaza, Los Angeles, California 90095, United States State Key Laboratory of Photocatalysis on Energy and Environment; College of Chemistry; Fuzhou University; China Department of Rheumatology, The Affiliated Changzhou No.2 People’s Hospital of Nanjing Medical University, Changzhou, China Mechanical & Aerospace Engineering Department, University of California, Los Angeles, California 90095 School of Chemical Engineering and Technology, Sun Yat-Sen University; Guangdong Provincial Key Laboratory of Emergency Test for Dangerous Chemicals, Guangdong Institute of Analysis Institute of Plant Protection Fujian Academy of Agriculture Sciences Fuzhou China; Fujian Key Laboratory for Monitoring and Integrated Management of Crop Pests Fuzhou China Department of General Surgery, Second Xiangya Hospital, Central South University, Changsha 410011, China. Department of Biological Chemistry, University of Michigan Medical School, 1150 West Medical Center Drive, Ann Arbor, MI 48109, USA.; Laboratory for Cell Biology and Genetics, Rockefeller University, 1230 York Avenue, New York, NY 10065, USA. Key Laboratory of Genetics and Birth Health of Hunan Province, the Family Planning Institute of Hunan Province, Changsha, Hunan 410126, P.R. China. chenyong0008@sina.com. Department of General Surgery, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China School of Pharmacy, East China University of Science and Technology, Shanghai, P.R. China Department of Cardiothoracic Surgery, the First Affiliated Hospital of GuangXi Medical University, Nanning, China Department of Hepatobiliary Surgery, Xijing Hospital, Fourth Military Medical University, Xi’an, Shaanxi, P.R. China Departments of Chemistry and Biochemistry and Mechanical and Aerospace Engineering, and California NanoSystems Institute, University of California, Los Angeles, 607 Charles E. Young Drive East, Los Angeles, California 90095-1569 Departments of Plastic and Reconstructive Surgery The Third Xiangya Hospital, Central South University Changsha; Emergency Department The First Hospital of Changsha Changsha Department of Orthodontics, Saveetha Dental College and Hospital, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai 600077, India; Department of Stomatology, School of Medicine, Xiamen University, 361005, China Department of Chemistry, City College of New York/CUNY, 138th Street and Convent Avenue, New York, New York 10031 Hubei Province Key Laboratory of Biotechnology of Chinese Traditional Medicine, Hubei University, Wuhan, China Department of Radiation Oncology, The First Affiliated Hospital Department of Medical Oncology, Subei People's Hospital, Clinical Medical College of Yangzhou University, Yangzhou, Jiangsu 225001, P.R. China Department of Musculoskeletal Surgery Fudan University Shanghai Cancer Center China Computational Systems Biology Laboratory , Department of Biochemistry and Molecular Biology and Institute of Bioinformatics, University of Georgia, Athens, Georgia 30602; School of Mathematics and System Sciences, Shandong University , Jinan 250100, Shandong, People's Republic of China and; School of Sciences, Jinan University, Jinan 250022, Shandong , People's Republic of China Department of Gastroenterology National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University Fuzhou China College of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, (Tianjin), Nankai University, Tianjin 300071, P. R. China Cancer Research Institute, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China. Department of Plastic Surgery, The Third Xiangya Hospital of Central South University, Changsha, Hunan 410013, P.R. China Department of Gynecology, The Fifth Affiliated Hospital of Sun Yat‑sen University, Zhuhai, Guangdong 519000, P.R. China College of Biotechnology and Pharmaceutical Engineering; Nanjing Tech University; Nanjing; China; National Engineering Technique Research Center for Biotechnology College of Chemistry State Key Laboratory of Elemento-Organic Chemistry Nankai University Tianjin 300071 China College of Pharmaceutical Sciences, Zhejiang University, 866 Yuhangtang Road, Hangzhou 310058, People's Republic of China Institutes for Integrated Cell‐Material Sciences (WPI‐iCeMS) Kyoto University Kyoto 606‐8501 Japan; PASTEUR Département de chimie école normale supérieure PSL Research University Sorbonne Universités UPMC Université Paris 06 CNRS Paris 75005 France Ecole Normale Supérieure, CNRS-ENS-UPMC UMR 8640, 24 rue Lhomond 2 , 75005 Paris, France; Institute for Integrated Cell-Material Sciences (iCeMS), Kyoto University 3 , Kyoto 606-8501, Japan Department of Hepatobiliary Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, P.R. China Department of Biostatistics, Epidemiology and Informatics,University of Pennsylvania, Philadelphia, PA, USA School of Civil Engineering & Architecture, Zhejiang University of Science & Technology, Hangzhou 310023, China Institute for Integrated Cell‐Material Sciences (WPI‐iCeMS) Kyoto University Yoshida‐Ushinomiya‐cho Sakyo‐ku Kyoto 606‐8501 Japan; Ecole Normale Supérieure CNRS‐ENS‐UPMC UMR 8640 24 Rue Lhomond Paris 75005 France National Engineering Technique Research Center for Biotechnology, State Key Laboratory of Materials-Oriented Chemical Engineering, College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, No. 30, Puzhu South Road, Nanjing 211816, China Department of Psychiatry, Center for Neurobiology and Behavior, The Perlman School of Medicine at University of Pennsylvania, Philadelphia, PA 19104, U.S.A. Innovation Center of Nursing Research and Nursing Key Laboratory of Sichuan Province, West China Hospital, Sichuan University/West China School of Nursing, Sichuan University, Chengdu 610041, China Department of Urology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, P.R. China Center for Advanced Food Technology and Department of Food Science, Cook College, Rutgers, The State University of New Jersey, 63 Dudley Road, New Brunswick, New Jersey 08901-8520 State Key Laboratory of Environmental Aquatic Chemistry, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, 100085, China Fourth Research Laboratory, Lanzhou Institute of Biological Products Co., Ltd., Lanzhou, China Guangzhou Institute of Energy Conversion, Chinese Academy of Sciences, Guangzhou 510640, China; School of Energy Science and Engineering, University of Science and Technology of China, Guangzhou 510640, China; Xiamen Key Laboratory of Clean and High-Valued Utilization for Biomass, Fujian Engineering and Research Center of Clean and High-Valued Technologies for Biomass, College of Energy, Xiamen University, Xiamen 361102, China; CAS Key Laboratory of Renewable Energy, Guangdong Provincial Key Laboratory of New and Renewable Energy Research and Development, Guangzhou 510640, China Department of Thoracic and Cardiovascular Surgery, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. cy19811125@126.com From the Department of Biostatistics, Epidemiology & Informatics, University of Pennsylvania, Philadelphia, Pennsylvania. Supelco Inc., 595 North Harrison Road, Bellefonte, Pennsylvania 16823, United States Department of Immunology, Bengbu Medical College, Bengbu 233003,China. Department of Chemistry & Biochemistry, The Ohio State University, Columbus, Ohio 43210, United States Department of Spinal Surgery, Xiangya Hospital of Central South University, Changsha, Hunan 410008, P.R. China Department of Medical Oncology, Guangxi Medical University Cancer Hospital National University of Defense Technology; Chengdu Fluid Dynamic Innovation Center Department of Interventional Radiology, General Hospital of Ningxia Medical University, Yinchuan, 750004, China Key Laboratory of Photochemical Conversion and Optoelectronic Materials and HKU-CAS Joint Laboratory on New Materials; Technical Institute of Physics and Chemistry; Beijing 100190, P.R. China Department of Neurology, Peking University Third Hospital, Beijing, China; Beijing Municipal Key Laboratory of Biomarker and Translational Research in Neurodegenerative Diseases, Beijing, China, and Department of Paediatric Surgery, KK Women's and Children's Hospital, Singapore College of Biotechnology and Pharmaceutical Engineering, Nanjing University of Technology, Nanjing, China. Department of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, People's Republic of China Key Laboratory of Photochemical Conversion and Optoelectronic Materials and HKU-CAS Joint Laboratory on New Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, People’s Republic of China State Key Laboratory Cultivation Base for TCM Quality and Efficacy, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China Key Laboratory of Plant Resources Institute of Botany The Innovative Academy of Seed Design Chinese Academy of Sciences Beijing China Department of General Surgery Xiangya Hospital Central South University Changsha China Department of Orthopedics, Jinling Hospital, Nanjing, Jiangsu 210002, P.R. China Department of Biostatistics, Epidemiology, and Informatics University of Pennsylvania Philadelphia Pennsylvania Hubei Province Key Laboratory of Biotechnology of Chinese Traditional Medicine; Collaborative Innovation Center for Green Transformation of Bio-Resources, Hubei University; Wuhan 430062 China Institute for Advanced Study; Nanchang University; Nanchang 330031; P. R. China Jinling Hospital, Department of Orthopedics, Nanjing University, School of Medicine, Nanjing 210002, Jiangsu Province, P.R. China Epstein Department of Industrial and Systems Engineering Department of Aerospace and Mechanical Engineering Viterbi School of Engineering University of Southern California 3715 McClintock Ave Los Angeles CA 90089‐01932 USA Department of Hepatobliliary Surgery, First Affiliated Hospital, Chongqing Medical University, Chongqing, China Department of Rheumatology, Ningbo no. 2 Hospital, Zhejiang, China. nbdeyycy@163.com. Division of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, State Key Laboratory for Oncogenes and Related Genes, Renji Hospital, School of Medicine, Shanghai JiaoTong University; Shanghai Institute of Digestive Disease;145 Middle Shandong Road, Shanghai, China Department of Otorhinolaryngology Head and Neck Surgery，thePeople'sHospital of Binhai County. Department of Hepatobiliary Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China Nanoscale Science and Technology Laboratory, Institute for Advanced Study, Nanchang University; College of Life Sciences, Nanchang University Department of Urology Surgery, Xi’an International Medical Center Hospital, Xi’an, China Department of Physics, Purdue University, West Lafayette, Indiana 47907, United States Department of Urology, The First People's Hospital of Longquanyi District Chengdu, Chengdu Shenzhen Key Laboratory of Musculoskeletal Tissue Reconstruction and Function Restoration, Division of Hand and Microvascular Surgery, Department of Orthopedic Surgery Shenzhen People's Hospital (the First Affiliated Hospital, Southern University of Science and Technology the Second Clinical Medical College, Jinan University) Shenzhen China College of Biological and Environmental Sciences, Zhejiang Wanli University, Ningbo 315100, PR China College of Life Sciences, Key Laboratory of Agricultural Environmental Microbiology of Ministry of Agriculture Nanjing Agricultural University Nanjing 210095 China Department of Radiation Oncology University of Oklahoma Health Sciences Center Oklahoma City OK 1State Key Laboratory of Biotherapy and Cancer Center, National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University, Chengdu, China. Department of Cardiology, Sichuan Provincal Pepole’s hospital, Chengdu Sichuan Province, China Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania USA Department of Radiation Oncology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA College of Chemistry and Chemical Engineering, Yunnan Normal University, Kunming 650092, P.R. China, and Key Laboratory of Photochemical Conversion and Optoelectronic Materials, CAS-HKU Joint Laboratory on New Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, P.R. China School of Laboratory Medicine, Chengdu Medical College, Chengdu, People’s Republic of China Research Center for Nanosensor Molecular Diagnostic & Treatment Technology, College of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen 518060, Guangdong, P. R. China; Graphene Composite Research Center, College of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen 518060, Guangdong, P. R. China Institute for Disease Control and Prevention of PLA, Beijing, China Department of Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan State Key Laboratory of Organic Geochemistry, Guangzhou Research Center of Mass Spectrometry, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou 510640, China; Graduate School of the Chinese Academy of Science, Beijing, China National University of Defence Technology College of Aerospace Science and Engineering, , 410073, Changsha, People's Republic of China Department of Thoracic Surgery, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China Center for Hospital Infection Control, Chinese PLA Institute for Disease Control & Prevention, Academy of Military Medical Sciences, Beijing 100071, China Pharmaron-Beijing Co. Ltd., 6 Taihe Road, BDA, Beijing 100176, PR China Center for Health Analytics and Synthesis of Evidence (CHASE), Department of Biostatistics, Epide-miology and Informatics, University of Pennsylvania , 423 Guardian Dr , Philadelphia, PA 19104, United States; Penn Medicine Center for Evidence-based Practice (CEP), University of Pennsylvania , 3600 Civic Center Blvd , Philadelphia, PA 19104, United States Hubei Collaborative Innovation Centre for Advanced Organic Chemical Materials; College of Chemistry and Chemical Engineering; Ministry of Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules; Hubei University; Wuhan Biomedical Engineering Inter-departmental Program and Department of Mechanical and Aerospace Engineering, University of California−Los Angeles, Los Angeles, California 90095 Guangxi Key Laboratory of Natural Polymer Chemistry and Physics, Nanning Normal University, Nanning, PR China California NanoSystems Institute and Department of Chemistry and Biochemistry, Department of Mechanical and Aerospace Engineering, and Department of Materials Science and Engineering, University of California, Los Angeles, 405 Hilgard Avenue, Los Angeles, CA 90095-1569 and Department of Chemical Engineering, and School of Chemistry, The University of Birmingham, Edgbaston, Birmingham, B15 2TT, U.K Department of Biostatistics and Epidemiology University of Pennsylvania Philadelphia PA 19104 USA Department of Nephrology, Xianning Central Hospital of Hubei Province Xianning 437100, China. College of Chemistry; State Key Laboratory of Elemento-Organic Chemistry; Nankai University; Tianjin 300071; China College of Materials and Chemistry Engineering; Hainan University; Haikou 570228; China State Key Laboratory of Electroanalytical Chemistry Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 130022, Changchun, China University of Pennsylvania. State Key Laboratory on Marine Resource Utilization in South China Sea; Hainan Provincial Key Laboratory of Research on Utilization of Si−Zr−Ti Resources; College of Materials and Chemical Engineering, Hainan University, 58 Renmin Road, Haikou 570228, China; Key Laboratory of Advanced Energy Materials Chemistry (Ministry of Education), Nankai University, Tianjin 300071, China Department of Musculoskeletal Surgery Fudan University Shanghai Cancer Center Department of Oncology Shanghai Medical College Fudan University Shanghai 200032 P. R. China Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia, PA Department of Biostatistics and Epidemiology, University of Pennsylvania , Philadelphia, Philadelphia 19104 , U.S.A. 1 Laboratory of Chemical Biology, Division of Biological Inorganic Chemistry, State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Changchun, Jilin 130022, China, 2Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, Changchun, Jilin 130022, China and 3Department of Neurosurgery, First Hospital of Jilin University, Changchun, Jilin 130021, China; 1 Laboratory of Chemical Biology, Division of Biological Inorganic Chemistry, State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Changchun, Jilin 130022, China, 2Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, Changchun, Jilin 130022, China and 3Department of Neurosurgery, First Hospital of Jilin University, Changchun, Jilin 130021, China; 1 Laboratory of Chemical Biology, Division of Biological Inorganic Chemistry, State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Changchun, Jilin 130022, China, 2Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, Changchun, Jilin 130022, China and 3Department of Neurosurgery, First Hospital of Jilin University, Changchun, Jilin 130021, China Department of Thoracic Surgery, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China. Department of Emergency, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, P.R. China Department of Chemistry, Ecole Normale Supérieure, Paris F-75005, France, and Department of Physics, Graduate School of Science, Kyoto University, Kyoto 606-8502, Japan State Key Laboratory of Synthetic Chemistry; HKU-CAS Joint Laboratory on New Materials; and Department of Chemistry; The University of Hong Kong; Hong Kong University of Pennsylvania , Philadelphia , USA College of Horticulture Northwest A&F University Yangling China Department of Radiology, Case Western Reserve University, Cleveland, USA. Department of Radiology and Intervention, The General Hospital of Ningxia Medical University, Yinchuan, China Pharmaron-Beijing Co. Ltd., 6 Taihe Road, BDA, Beijing 100176, P. R. China Department of Expanded Program on Immunization, Jiangsu Provincial Center for Disease Control and Prevention, China Key Laboratory of Genetics and Birth Health of Hunan Province Changsha China Department of Rehabilitation Medicine, Huaihe Hospital of Henan University, Kaifeng, China. Laboratory of Natural and Targeted Small Molecule Drugs, State Key Laboratory of Biotherapy and Cancer Center, Collaborative Innovation Center of Biotherapy, West China Hospital of Sichuan University, Chengdu 610041, China Department of Radiation Oncology University of Oklahoma College of Medicine Oklahoma City Oklahoma USA Department of Infection, the Affiliated Hospital of Shanxi Datong University, Datong 037005, Shanxi, China. State Key Laboratory of Molecular Biology, National Center for Protein Science, Shanghai Science Research Center, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, 333 Haike Road, Shanghai 201210, China Orthopedic Center, The Second Affiliated Hospital of Soochow University, Suzhou, China; Kunshan Hospital of Traditional Chinese Medicine, Kunshan 215300, China; Institute of Translational Medicine, Medical College, Yangzhou University, Yangzhou 225001, China Animal Zoology Department, Institute of Neuroscience Kunming Medical University Kunming China Department of Biomedical Engineering, Purdue School of Engineering and Technology, Indiana University-Purdue University at Indianapolis, Indianapolis, IN, USA Department of Hepatobiliary Surgery, First Affiliated Hospital of Chongqing Medical University, Chongqing 400042, P.R. China Chengdu Environmental Monitoring Center Chengdu China Epstein Department of Industrial and Systems Engineering University of Southern California 3715 McClintock Ave Los Angeles CA 90089‐01932 USA; Department of Aerospace and Mechanical Engineering Viterbi School of Engineering University of Southern California 3650 McClintock Ave Los Angeles CA 90089 USA State Key Laboratory of Atmospheric Boundary Layer Physics and Atmospheric Chemistry, Institute of Atmospheric Physics, Chinese Academy of Sciences, Beijing 100029, China Department of Anesthesiology, Jiangxi Key Laboratory of Anesthesiology, Second Affiliated Hospital of Nanchang University, Nanchang 330000, Jiangxi, China. Corresponding author: Xu Wenhao, Email: xwhpf2009@sohu.com. School of Marine Sciences, University of Maine, Orono, ME 04469; School of Basic Medical Science, Weifang Medical University, Weifang 261053, China Department of Hepatobiliary Surgery Xijing Hospital, Fourth Military Medical University Xi'an Shaanxi People's Republic of China Institute for Biomedical Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA; Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA; Center for Evidence-based Practice, The University of Pennsylvania, Philadelphia, Pennsylvania, USA; Applied Mathematics & Computational Science, Penn Arts & Sciences, University of Pennsylvania, Philadelphia, Pennsylvania, USA Stroke Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA From the Department of Physiology and Biophysics (C.L.D., A.T.C., B.D.H., X.Y., J.E.S.), the Department of Biomedical Engineering (Y.C., X.Y.), and the Department of Medicine (B.D.H.), Case Western Reserve University, Cleveland, OH. Anhui Provincial Key Laboratory of Infection and Immunity, Bengbu 230030, China. Department of Oral and Maxillofacial Surgery, Institute and Hospital of Stomatology, Nanjing University Medical School, Nanjing Jiangsu, 210008, P.R.China. chenyongsurgeon@hotmail.com Department of Radiation Oncology University of Oklahoma Health Sciences Center Oklahoma City OK USA Division of Biostatistics, Center for Clinical Epidemiology and Biostatistics State Key Laboratory of Molecular Biology, National Center for Protein Science Shanghai, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences; University of Chinese Academy of Sciences, 333 Haike Road, Shanghai 201210, China; School of Life Science and Technology, Shanghai Tech University, 100 Haike Road, Shanghai 201210, China; Shanghai Science Research Center, Chinese Academy of Sciences, Shanghai 201204, China Department of Musculoskeletal Oncology Cancer Hospital of Fudan University Shanghai China Institute for Biomedical Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA; Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, Philadelphia, Pennsylvania, USA State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry of the Chinese Academy of Sciences, Changchun 130022, China, and College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China Department of Chemistry, Institute for Proteomics Technology and Applications, The George Washington University, Washington, DC 20052, and Nanosys, Inc., 2625 Hanover Street, Palo Alto, California 94304 Nanjing University of Traditional Chinese Medicine, Nanjing, China School of Chemical & Environmental Engineering; China University of Mining & Technology; Beijing 100083; China Department of Radiology, Liyang People’s Hospital Affiliated to Nantong University, Changzhou, Jiangsu Province, China Department of Radiation Oncology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China College of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Nankai University, China Ecole Normale Superieure 2 , 24 rue Lhomond, Paris, France Contribution from the Department of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, P. R. China Hubei Province Key Laboratory of Biotechnology of Chinese Traditional Medicine, National and Local Joint Engineering Research Center of High‑throughput Drug Screening Technology, Hubei University, Wuhan, Hubei 430062, P.R. China School of Life Sciences Lanzhou University Lanzhou China Department of Biostatistics, Epidemiology and Informatics, The Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania USA Institute for Interdisciplinary Research & Key Laboratory of Optoelectronic Chemical Materials and Devices of Ministry of Education; Jianghan University; Wuhan 430056, China; Département de Chimie; Ecole Normale Supérieure Division of Biostatistics, The University of Texas School of Public Health , Houston, Texas 77030 , U.S.A. Beijing An-zhen Hospital, Beijing 100029, China. University of Pennsylvania, USA College of Pharmacy Nanjing University of Chinese Medicine Nanjing People’s Republic of China Pharmaron-Beijing Company Limited, 6 Taihe Road BDA, Beijing 100176, PR China Key Laboratory of Photochemical Conversion and Optoelectronic Materials and HKU-CAS Joint Laboratory on New Materials, Technical Institute of Physics and Chemistry and University of Chinese Academy of Sciences, CAS, Beijing 100190, People’s Republic of China State Key Laboratory Cultivation Base for TCM Quality and Efficacy, Nanjing University of Chinese Medicine, Nanjing 210023, People’s Republic of China; State Key Laboratory of Pharmaceutical Biotechnology, Institute of Functional Biomolecules, Nanjing University, Nanjing 210023, People’s Republic of China Department of Vascular Surgery, The Clinical Medical College of Yangzhou University, Yangzhou, China Pfizer, Inc. Groton Connecticut USA Department of Stomach and Soft Tissue Tumors, Fudan University Cancer Center, Shanghai 200032, China. chenyong780417@gmail.com Laboratoire de Photonique et de Nanostructures, CNRS, Marcoussis, 91460, France Key laboratory of Genetics and Birth Health of Hunan Province Family Planning Research Institute of Hunan Province Changsha Hunan 410126 China Department of Chemistry, University of Waterloo, Waterloo, Ontario, N2L 3G1, Canada Hubei University of Science and Technology, 418442, Xianning, Hubei , China, ; Authors' Affiliations: 1Departments of Hepatobiliary Surgery and Pathology, Xijing Hospital, The Fourth Military Medical University, Xi'an, Shanxi, P.R. China; 2Anhui Key Laboratory for Cellular Dynamics, University of Science & Technology of China, Hefei, China; 3Department of Medicine, Beijing University of Chinese Medicine, Beijing, China; 4Cancer Biology Program, Department of Obstetrics and Gynecology, Morehouse School of Medicine, Atlanta, Georgia; and 5Department of Pathology, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania Department of Radiology Case Western Reserve University Cleveland OH USA Hubei Provincial Key Laboratory of Biotechnology of Traditional Chinese Medicine, Hubei University, Wuhan 430062, China. cy101610@npc.gov.cn College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, Hubei, China State Key Laboratory of Membrane Biology & Beijing Frontier Research Center for Biological Structure, School of Life Sciences, Tsinghua University, Beijing 100084, China; Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing 100084, China Viterbi School of Engineering University of Southern California Los Angeles California Department of Orthopaedics, Nanjing General Hospital of Nanjing Military Command of PLA, Nanjing 210002, Jiangsu, China. chenyoong@sina.com Departments of Radiology, University of North Carolina, Chapel Hill, NC, USA; Biomedical Research Imaging Center (BRIC), University of North Carolina at Chapel Hill, NC, USA. Department of Ophthalmology, Zhuji Central Hospital, Zhuji, Zhejiang 311800, China. Hubei Province Key Lab of Bio-Technology of Traditional Chinese Medicine, Hubei University, Wuhan 430062, China. cy101610@npc.gov.cn Department of Applied Mathematics and Statistics, Stony Brook University, Stony Brook, NY 11794–3600, USA. Key Laboratory of Bio‐Inspired Materials and Interfacial Science Technical Institute of Physics and Chemistry Chinese Academy of Sciences Beijing 100190 P. R. China Guangdong Provincial Engineering Research Center for Reverse Engineering of Industrial Additives , Guangdong Provincial Key Laboratory of Chemical Measurement and Emergency Test Technology, Institute of Analysis, Guangdong Academy of Sciences (China National Analytical Center,Guangzhou), Xianlie Middle Road 100, Guangzhou 510070, P. R. China University of Electronic Science and Technology of China 1 School of Energy Science and Engineering, , Chengdu 611731, China; The University of Adelaide 2 School of Mechanical Engineering, , SA 5005 Australia State Key Laboratory on Marine Resource Utilization in South China Sea; Hainan Provincial Key Laboratory of Research on Utilization of Si-Zr-Ti Resources; College of Materials Science and Chemical Engineering; Hainan University; Haikou Department of Rheumatology and Immunology Huadong Hospital affiliated with Fudan University Shanghai China Rheumatology Department, Integrated Traditional Chinese and Western Medicine Hospital, Southern Medical University, Guangzhou 510315, China Ecole Normale Supérieure-PSL Research University; Département de Chimie; Sorbonne Universités – UPMC Univ Paris 06; CNRS UMR 8640 PASTEUR; 75005 Paris Department of Infectious Diseases, The First Affiliated Hospital of Hebei North University, Zhangjiakou, 075000 Hebei, China School of Materials Science and Engineering, Zhengzhou University, Zhengzhou 450001, P. R. China Ecole Normale Supérieure, CNRS-ENS-UPMC UMR 8640, 24 rue Lhomond, 75005 Paris, France, and Institute for Integrated Cell-Material Science (iCeMS), Kyoto University, Kyoto 606-8507, Japan Department of Microbiology and Parasitology, Bengbu Medical College, Anhui Key Laboratory of Infection and Immunity, Bengbu 233030, China. *Corresponding author, E-mail: 787717617@qq.com. Construction Engineering College, Jilin University, Changchun, Jilin Province 130026, P. R. China; Phases to Flow Laboratory, Chemical & Biological Engineering Department, Colorado School of Mines, Golden, Colorado 80401, United States Department of Pathology, Anhui Province Maternity and Child Health Hospital, Anhui Medical University, Hefei, Anhui 230000, P.R. China Postdoctoral Innovation Practice Base, The First Affiliated Hospital of Nanchang University, Nanchang, 330006, People's Republic of China. Department of Biostatistics, Epidemiology and Informatics, the Perelman School of Medicine, University of Pennsylvania, Pennsylvania Department of Urology, Chongqing University Fuling Hospital, Chongqing, China cBiostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania Institute of Organic Chemistry, University of Vienna, Währinger Strasse 38, Wien, Vienna 1090, Austria National Heart, Lung, and Blood Institute, Bethesda, Maryland 20892, United States School of Chemistry and Chemical Engineering, Testing Center, Yangzhou University, Yangzhou 225009, P. R. China for the VICTORIA Study Group Zhejiang Institute for Drug Control, Hangzhou 310004, China. zhouzhou0311@126.com Key Laboratory of Photochemical Conversion and Optoelectronic Materials Technical Institute of Physics and Chemistry Chinese Academy of Sciences 29 Zhongguancun East Road Beijing 100190 P.R. China University of Electronic Science and Technology of China School of Energy Science and Engineering, , Chengdu 611731, China Department of Bone and Soft Tissue Sarcomas Fudan University Shanghai Cancer Center Shanghai China; Department of Oncology Shanghai Medical College Fudan University Shanghai China Department of Life Sciences, Hunan Institute of Humanities, Science and Technology, Loudi 417000, China Pharmaceutical Institute, Nanjing University of Chinese Medicine, Nanjing, P.R. China Department of Clinical Laboratory, The First Hospital of Changsha City, Hunan, People’s Republic of China College of Plant Protection, Key Laboratory of Integrated Pest Management in Crops in Eastern China, Ministry of Agriculture Nanjing Agricultural University Nanjing China Department of Cardiology, Sichuan Provincial People’s Hospital, Chengdu, Sichuan Province, China Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, TX 77555-1069, USA College of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Nankai University, 94 Weijin Road, Nankai District, Tianjin 300071, P.R. China Department of Critical Medicine, The People's Hospital of Dazu District, Chongqing, China Multidisciplinary Center for Pituitary Adenomas of Chongqing, Department of Neurosurgery, Xinqiao Hospital, Army Medical University, Chongqing, China Discipline of Orthodontics, Faculty of Dentistry The University of Hong Kong Hong Kong China Key Laboratory of Plant Resources Institute of Botany, Chinese Academy of Sciences Beijing 100093 China Department of Radiation Oncology, University of Oklahoma Health Sciences Center 2 , Oklahoma City, Oklahoma 73104, USA Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fujian Medical University, Fuzhou 350004, China Department of Biological Sciences and Biotechnology, State-Key Laboratory of Biomembranes, Tsinghua University, Beijing 100084, China; and Department of Biology, Georgia State University, Atlanta, GA 30303 Department of Neurology, Children’s Hospital of Jiangxi Province, Nanchang, China. Department College of Chemistry Nankai University Tianjin 300071 P. R. China Department of Interventional Radiology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China National & Local Joint Engineering Research Center of High-throughput Drug Screening Technology; Hubei Key Laboratory of Biotechnology of Chinese Traditional Medicine; School of Life Sciences; Hubei University; Wuhan 430062 for the RECOVER Consortium Department of Neurology, Jiangxi Provincial Children’s Hospital, Nanchang, China. National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.; Department of Biological Sciences, Center for Systems Biology, The University of Texas at Dallas, Richardson, TX, USA. Fujian Province Key Laboratory of Plant Virology, Institute of Plant Virology, Fujian Agriculture and Forestry University, Fuzhou, Fujian 350002, PR China Ecole Normale Supérieure, CNRS-ENS-UPMC 8640, 24 rue Lhomond, 75005 Paris, France; Institute for Integrated Cell-Material Sciences, Kyoto University, 606-8507 Kyoto, Japan College of Biotechnology, Jiangsu University of Science and Technology, Zhenjiang 212100, China Emergency Department, Hospital of Chengdu University of Traditional Chinese Medicine , Chengdu , China Merck & Co. Inc. Kenilworth New Jersey USA State Key Laboratory of Marine Resource Utilization in South China Sea Hainan Provincial Key Laboratory of Research on Utilization of Si-Zr-Ti Resources Hainan University 58 Renmin Road Haikou 570228 China College of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, P.R. China College of Field Engineering; Army Engineering University of PLA; Nanjing; China Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, Philadelphia, PA Chinese Academy of Sciences Key Laboratory of Plant Resources, Institute of Botany, The Innovative Academy of Seed Design, , Beijing 100093, China Institute of Plant Protection, Fujian Academy of Agricultural Sciences, Fuzhou, China; Fujian-Taiwan Joint Centre for Ecological Control of Crop Pests, Fujian Agriculture and Forestry University, Fuzhou, China; Fujian Key Laboratory for Monitoring and Integrated Management of Crop Pests, Fuzhou, China; Fuzhou Scientific Observing and Experimental Station of Crop Pests of Ministry of Agriculture, Fuzhou, China Shanghai Municipal Center for Diseases Control and Prevention, Shanghai, China Ecole Normal Supérieure 1 , CNRS-ENS-UPMC UMR 8640, 24 rue Lhomond, Paris 75231, France; Peking University 2 Centre for Microfluidics and Nanotechnology, , Beijing 100871, China; Kyoto University 3 Institute for Integrated Cell-Material Science, , Kyoto 606-8507, Japan Department of Physics, School of Physics, and Center of Nanoscience and Nanotechnology, Wuhan University, Wuhan 430072, China, and Ecole Normale Superieure, 24 rue Lhomond, 75231 Paris, France Data Analytics and Observational Methods Center for Observational & Real World Evidence, Merck & Co., Inc USA Chinese PLA Center for Disease Control & Prevention Beijing China; Huoshenshan Hospital Wuhan China Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA Department of Neurology, University of Würzburg, Josef-Schneider-Strasse 11, Würzburg 97080, Germany Department of Biostatistics and Epidemiology University of Pennsylvania Philadelphia Pennsylvania 19104 U.S.A. Department of Chemistry, Nankai University, Tianjin, 300071, China Department of Orthopaedics; Jinling Hospital; Nanjing 210002; China Institute of Cytology and Genetics, The Hengyang Key Laboratory of Cellular Stress Biology, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, P.R. China Department of Epidemiology, School of Public Health, Fudan University, Shanghai, China; Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA Technical Institute of Physics and Chemistry Chinese Academy of Sciences Beijing 100190 P. R. China Centre for Advanced Macromolecular Design, School of Chemistry The University of New South Wales Sydney NSW 2052 Australia Department of Radiology and BRIC, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. University of Oklahoma Health Science Center Stephenson Oklahoma Cancer Center Oklahoma City OK USA State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, No. 5 Xinmofan Road, Nanjing 210009, China; College of Biotechnology and Pharmaceutical Engineering, National Engineering Technique Research Center for Biotechnology, Nanjing Tech University, No. 30 Puzhu South Road, Nanjing 211816, China; Synergetic Innovation Center for Advanced Materials, Nanjing Tech University, No. 30 Puzhu South Road, Nanjing 211816, China Institute for Interdisciplinary Research & Key Laboratory of Optoelectronic Chemical Materials and Devices of Ministry of Education; Jianghan University; Wuhan 430056; China; Département de Chimie 1 Department of Bioinformatics and Computational Biology, The University of Texas M. D. Anderson Cancer Center, 2Biomathematics and Biostatistics, Graduate School of Biomedical Sciences, The University of Texas Health Science Center at Houston and 3Division of Biostatistics, The University of Texas Health Science Center at Houston, Houston, TX, USA Department of General Surgery, Baoshan Branch, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China. National Engineering Research Center for Biotechnology, College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing 211816, China; State Key Laboratory of Materials-Oriented Chemical Engineering, College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing 211816, China Jiangsu Provincial Academy of Environmental Science, Nanjing 210036, China; School of Environmental and Biological Engineering, Nanjing University of Science and Technology, Nanjing 210094, China State Key Laboratory of Materials-Oriented Chemical Engineering, College of Life Science and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, 210009, P.R. China; National Engineering Technique Research Center for Biotechnology, Nanjing Tech University, Nanjing, 211009, China State Key Laboratory of Biotherapy, Collaborative Innovation Center of Biotherapy and Cancer Center, West China Hospital of Sichuan University, Chengdu 610041, China Shenzhen Key Laboratory of Smart Healthcare Engineering, Department of Biomedical Engineering, Southern University of Science and Technology, No. 1088, Xueyuan Rd., Xili, Nanshan District, Shenzhen, Guangdong 518055, P. R. China; Guangdong Provincial Key Laboratory of Advanced Biomaterials, Southern University of Science and Technology, Shenzhen, Guangdong 518055, P. R. China College of Life Sciences, Nanchang University, Nanchang, Jiangxi, P.R. China;; Nanoscale Science and Technology Laboratory, Institute for Advanced Study, Nanchang University, Nanchang, Jiangxi, P.R. China; Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA State Key Laboratory of Ecological Pest Control for Fujian and Taiwan Crops, Institute of Plant Protection, Fujian Academy of Agricultural Sciences, Fuzhou 350013, China; Fujian Key Laboratory for Monitoring and Integrated Management of Crop Pests, Fuzhou Scientific Observing and Experimental Station of Crop Pests of the Ministry of Agriculture, Fuzhou 350013, China Beckman Coulter Life Sciences Miami Florida Proteomics Core National Heart, Lung and Blood Institute National Institutes of Health Bethesda MD USA Department of Hepatobiliary Surgery, Xijing Hospital, Fourth Military Medical University , Xi'an 710033 , China Guangzhou Institute of Energy Conversion, Chinese Academy of Sciences, Guangzhou510640, China; CAS Key Laboratory of Renewable Energy, Guangdong Provincial Key Laboratory of New and Renewable Energy Research and Development, Guangzhou510640, China Department of Oral and Maxillofacial Surgery, Cangzhou Central Hospital, Cangzhou, China; College of Pharmaceutical Sciences Zhejiang University Hangzhou China Department of Biomedical Engineering; Southern University of Science and Technology (SUSTech); Shenzhen 518055; China Department of Rheumatology and Immunology, Affiliated Hospital of Zunyi Medical University, Zunyi, China State Key Laboratory and Institute of Elemento-organic Chemistry, Nankai University, Tianjin 300071, China Laboratory of Natural and Targeted Small Molecule Drugs, State Key Laboratory of Biotherapy and Cancer Center and Collaborative Innovation Center of Biotherapy, West China Hospital of Sichuan University, Chengdu 610041, China National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China; College of Life Sciences, University of Chinese Academy of Sciences, Beijing, China Laboratory of Cellular Physiology and Immunology, The Rockefeller University, New York, New York 10021, and Celgene Corporation, Warren, New Jersey 07059 Department of Biomedical Engineering Case Western Reserve University Cleveland Ohio USA Department of Medical Laboratorial Examination, The First Affiliated Hospital, Fujian Medical University, Fuzhou 350005, Fujian Pro-vince, China. Merck & Co., Inc. Kenilworth New Jersey USA College of Chemistry Fuzhou University Fuzhou 350116 P. R. China Physics School, Peking University, 100871 Peking, China, Department of Chemistry, Ecole Normale Supérieure, Paris F-75005, France, INSERM, U571, Paris F-75015, France, and Université Paris Descartes, Faculté de Médecine Necker, Paris F-75730, France Laureen Ribassin-Majed, Sophie Marguet, Jean Pierre Pignon, and Pierre Blanchard, Ligue Nationale Contre le Cancer meta-analysis platform, Gustave-Roussy, Université Paris-Saclay; Centre for Research in Epidemiology and Population Health, INSERM U1018, Université Paris-Saclay, Villejuif, France; Anne W.M. Lee and Wai Tong Ng, Pamela Youde Nethersole Eastern Hospital; Anthony T.C. Chan, The Chinese University of Hong Kong; Daniel T.T. Chua, Hong Kong Sanatorium & Hospital; Dora L.W. Kwong, Queen Mary... Department of Cardiothoracic Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, China Department of Chemistry State Key Laboratory of Elemento‐Organic Chemistry Nankai University Tianjin 300071 P. R. China; Collaborative Innovation Center of Chemical Science and Engineering Nankai University Tianjin 300071 P. R. China Radiology Case Western Reserve University Cleveland Ohio USA Ecole Normale Supérieure 24 rue Lhomond Paris 75231 France Department of Radiation Oncology, Sun Yat-Sen University Cancer Center, Guangzhou 510060, China; State Key Laboratory of Oncology in Southern China, Guangzhou 510060, China; Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China Xuzhou City Centers for Disease Control and Prevention, Xuzhou 221006, China. Department of Occupational and Environmental Medicine, College of Public Health, Central South University, Changsha, Hunan, China Key Laboratory of Plant Resources, Institute of Botany, Chinese Academy of Sciences, Beijing, China; Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu610041, China |
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