http://rdf.ncbi.nlm.nih.gov/pubchem/author/MD5_da3adc34c73ca2cc3438ca09b4e6e0c6
Outgoing Links
| Predicate | Object |
|---|---|
| family-name | Chen |
| name | Rui Chen |
| given-name | Rui |
| organization-name | Department of Obstetrics and Gynecology, Center for Reproductive Medicine, Key Laboratory for Major Obstetric Diseases of Guangdong Province, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, PR China; Key Laboratory for Reproductive Medicine of Guangdong Province, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, PR China Biomedical Research Center and Key Laboratory of Biotherapy of Zhejiang Province, Zhejiang University, Hangzhou, Zhejiang, China Department of Chemistry, University of Alberta, Edmonton, Alberta, Canada Center of Super-Diamond and Advanced Films (COSDAF); and Department of Physics and Materials Science; City University of Hong Kong; Kowloon; P. R. China School of Life Sciences, Southern University of Science and Technology, Shenzhen, China Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030 8 School of Journalism, Communication University of China, Beijing 100024, China Department of Plastic and Reconstructive Surgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200001, People’s Republic of China Department of Breast Disease, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, 210000, China Department of Biostatistics and Computational Biology; University of Rochester; Rochester New York 1 Department of Pediatrics, Baylor College of Medicine, USDA/ARS Children’s Nutrition Research Center, Houston, TX 77030, USA, 2Department of Molecular & Cell Biology, Baylor College of Medicine, Houston, TX 77030, USA, 3Department of Biology and Biochemistry, University of Houston, Houston, TX 77204, USA and 4Department of Molecular & Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA From the Department of Molecular and Cellular Biology (A.O., M.I., R.C., A.I., M.O., S.F., M.M., M.H.), Division of Medical Biochemistry and Cardiovascular Biology, and Second Department of Internal Medicine (A.O., T.Y., J.H.), Ehime University School of Medicine, Tohon, Ehime, Japan. Department of Neonatology, Shenzhen Bao'an Maternal and Child Health Hospital, Shenzhen, Guangdong 518133, China. maliya226@qq.com. Department of Colorectal Surgery, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou 310016, China Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment; Department of Pathology, Chongqing University Cancer Hospital & Chongqing Cancer Institute & Chongqing Cancer Hospital, Chongqing, P.R. China. Institute of Pathology, Case Western Reserve University, Cleveland, OH 44106; and The Dana Institute, Drew University, Madison, NJ 07940 Gregory L. Lyons, Department of Rehabilitation Psychology and Special Education, University of Wisconsin-Madison; Heartley B. Huber, Department of Special Education, Vanderbilt University; Erik W. Carter, Department of Special Education, Vanderbilt University; Rui Chen, Department of Special Education, Vanderbilt University; and Jennifer M. Asmus, Department of Educational Psychology and the Wais Stanford University, Palo Alto, California, United States Laboratory of Mesoscopic Chemistry and Department of Polymer Science and Engineering, College of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, China Department of Molecular and Human Genetics Baylor College of Medicine Houston Texas CAS Key Lab of Separation Sciences for Analytical Chemistry, National Chromatographic Research and Analysis Center, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China, and The Second Affiliated Hospital of Dalian Medical University, Dalian 116027, China Department of Gynecology, The First Affiliated Hospital of Xi'an Medical University, Xi'an 710077, China. College of Pharmacy Guangxi University of Chinese Medicine Nanning 530001 China Department of Hematology, Guangdong Second Provincial General Hospital, Guangzhou, Guangdong 510317, P.R. China 2Department of Cardiovascular & Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio. Data-Enabled Life Sciences Alliance (DELSA Global), Seattle, Washington.; Department of Genetics, Stanford University, Stanford, California. Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA. Division of Physics and Applied Physics Centre for Disruptive Photonic Technologies (CDPT) School of Physical and Mathematical Sciences Nanyang Technological University 21 Nanyang Link Singapore 637371 Singapore Department of Genetics, Stanford University, 1501 South California Avenue, Palo Alto, California 94304, United States From the Department of Medical Biochemistry, Ehime University School of Medicine, Ehime (L.W., M.I., H.N., Z.L., R.C., J.S., M.H.), and the Department of Geriatric Medicine, Kyorin University School of Medicine, Tokyo (M.A.), Japan; and Novartis Pharma AG, Basel, Switzerland (M.d.G.). Human Health Therapeutics, National Research Council of Canada , Ottawa, ON K1A 0R6 , Canada Human Genome Sequencing Center, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas Key Laboratory of Clinical Laboratory Diagnostics (Ministry of Education), College of Laboratory Medicine, Chongqing Medical University, Chongqing 400016, China Department of Gynecology, Qingpu Branch of Zhongshan Hospital, Fudan University, Shanghai 201799, P.R. China UK Centre for Tissue Engineering, UKBioTec Laboratories, University of Liverpool, Liverpool, United Kingdom. Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA. Louisiana State University, Department of Entomology, Baton Rouge, LA School of Chemistry and Chemical Engineering, Guangzhou University, Guangzhou 510006, China Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas, United States 2Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States 4Structural and Computational Biology and Molecular Biophysics Angecon Biotechnology Limited, Shanghai 201318, China Department of Orthopedics, Changzheng Hospital, Second Military Medical University, Shanghai, China Department of Urology, Shanghai Changhai Hospital, Second Military Medical University, Shanghai, China School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, China Department of Pathology, Chongqing University Cancer Hospital & Chongqing Cancer Institute & Chongqing Cancer Hospital, Chongqing 400030, P.R. China College of Chemistry; School of Materials Science and Engineering; Institute of New Catalytic Materials Science; Key Laboratory of Advanced Energy Materials Chemistry (MOE); Collaborative Innovation Center of Chemical Science and Engineering (Tianjin) Department of Orthopedics, Taihe Hospital Hubei University of Medicine Shiyan Hubei China School of Chemistry and Chemical Engineering, Hefei University of Technology, 193 Tunxi Road, Anhui 230000, China Department of Chemistry, Indiana University, 800 East Kirkwood Avenue, Bloomington, Indiana 47405 Department of Oncology, The Third Affiliated Hospital of Soochow University, The First People's Hospital of Changzhou, no 185 Juqian Road, Tianning District, Changzhou, 213003, China From the Department of Molecular and Human Genetics (K.M., L.C.B., M.J., R.A.L., M.X., J.A.R., R.C., C.M.E., Y.Y., B.H.L., P.M.M., S.U.D.), Department of Neurology (J.J., D.V., P.M.M), and Department of Ophthalmology (R.A.L.), Baylor College of Medicine; Department of Pathology (G.N.F.), Department of Neuro-Oncology (M.P.-P.), and Department of Diagnostic Imaging (M.K.G.-M.), The University of Texas MD Anderson Cancer Center; Michael E. DeBakey VA Medical Center (P.M.M.); Baylor Genetics (C.M.E., Y... Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University Clinical Pharmacology Research Center, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing 100730, PR China; Beijing Key Laboratory of Clinical PK & PD Investigation for Innovative Drugs, Beijing Municipal Science & Technology Commission, Beijing 100195, PR China Department of Chemistry, University of Alberta, W3-39 Chemistry Building, T6G 2G2, Edmonton, Alberta, Canada CAS Engineering Laboratory for Nanozymes Institute of Biophysics Chinese Academy of Sciences Beijing 100101 China School of Materials Science and Engineering Nankai University Tianjin 300350 China Jiangsu Key Laboratory of Drug Design and Optimization, Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, P. R. China Department of Cell Biology, Cleveland Clinic, Cleveland, OH 44195 Research Center for Swine Diseases, College of Veterinary Medicine, Sichuan Agricultural University , Chengdu, China State Key Laboratory of New Drug and Pharmaceutical Process, Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry, Shanghai 200437, China; Shanghai Professional and Technical Service Center for Biological Material Drug-ability Evaluation, Shanghai 200437, China Department of Toxicology and Sanitary Chemistry, School of Public Health, Capital Medical University, Beijing, PR China; Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing, PR China Hematology Section, Department of Laboratory Medicine, Clinical Center, National Institutes of Health (NIH), Bethesda, MD;; Department of Laboratory Medicine, Beijing TongRen Hospital, Capital Medical University, Beijing, China; Guangdong‐Hong Kong‐Macao Joint Laboratory for Photonic‐Thermal‐Electrical Energy Materials and Devices Shenzhen Key Laboratory for Advanced Quantum Dot Displays and Lighting Department of Electrical and Electronic Engineering Southern University of Science and Technology 1088 Xueyuan Blvd. Shenzhen 518055 China Key Laboratory of Zoological Systematics and Evolution Institute of Zoology Chinese Academy of Sciences No. 1 Beichen West Road Chaoyang District Beijing 100101 China; College of Life Sciences University of Chinese Academy of Sciences No. 19 Yuquan Road Shijingshan District Beijing 100049 China Department of Cardiology, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu Province, China Department of Integrated Traditional Chinese Medicine and Western Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China Department of Microbiology and Molecular Genetics, University of California, Davis, California, USA Ottawa Institute of Systems Biology, Department of Biochemistry, Microbiology and Immunology, University of Ottawa, 451 Smyth Rd., Ottawa, Ontario, Canada, K1H8M5 Tianjin Institute of Agricultural Quality Standard and Testing Technology, Tianjin Academy of Agricultural Sciences, Tianjin, China. Department of Cardiology, Affiliated Hospital of Jiangsu University, Zhenjiang, China Department of Nanomedicine, Houston Methodist Research Institute, Houston, Texas 77030, United States; Department of Cell and Developmental Biology, Weill Medical College of Cornell University, New York, New York 10065, United States; The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, Guangdong 510150, China Centre of Excellence for Biofilm Science (CEBS) 5D Health Protection Group Ltd. Liverpool UK Department of Thyroid and Breast Surgery, The Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou 563000, P.R. China Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States 2Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas, United States 4Structural and Computational Biology and Molecular Biophysics Ottawa Institute of Systems Biology, Department of Biochemistry, Microbiology and Immunology, University of Ottawa, 451 Smyth Road, Ottawa, ON, Canada K1H8M5 Institute of Zoology, Chinese Academy of Sciences, Chaoyang District, Beijing, P.R. China National Engineering Research Center for Miniaturized Detection Systems, School of Life Sciences, Northwest University, Xi'an, China Departments of Medical Biochemistry (L.-J.M., T.-X.C., T.S., H.-W.L., R.C., J.-M.L., M.O., T.J., L.W., M.I., M.H.), Ehime University Medical School, Ehime 791-0295, Japan Division of Computer, Electrical, and Mathematical Science and Engineering, 4700 King Abdullah University of Science and Technology 1 , Thuwal 23955-6900, Saudi Arabia College of Science, Jilin Provincial Key Laboratory of Human Health Status Identification and Function Enhancement, Changchun University, Changchun 130022, P.R. China Department of Pharmacology Ningxia Medical University Yinchuan China State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, Fourth Military Medical University, 710032 Xi'an, People's Republic of China Center for Pediatric Liver Diseases, Children's Hospital of Fudan University, Shanghai 201102, China. School of Polymer Science and Polymer Engineering, The University of Akron, Akron, Ohio 44325, United States Department of Materials Science and Engineering, University of California, Berkeley, California 94720, United States College of Engineering, Huazhong Agricultural University, Wuhan 430070, Hubei, China Department of General Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou 563003, P.R. China Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200071, China. Key Laboratory of Analytical Chemistry for Living Biosystems, Institute of Chemistry Chinese Academy of Sciences, Beijing National Laboratory for Molecular Sciences, Beijing, China Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States 2Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas, United States 4Department of Structural and Computational Biology & Molecular Biophysics, Baylor College of Medicine, Houston, Texas, United States 5Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas, United States 6Program of Developmental Biology, Baylor College of Medicine, Houston, Texas, United States. School of Basic Medical Science, Health Science Center, Ningbo University, Ningbo, Zhejiang, 315211, P. R. China School of Arts and Sciences, Shanghai Dianji University, Shanghai 201306, China Laboratory of Molecular Toxicology, State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, P. R. China Key Laboratory of Animal Genetics, Breeding and Reproduction in the Plateau Mountainous Region, Ministry of Education, College of Animal Science, Guizhou University, Guiyang 550025, China Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou City, Guangdong Province, China College of Pharmacy, Changchun University of Chinese Medicine, Changchun 130021, China Department of Toxicology and Sanitary Chemistry, School of Public Health, and Beijing Key Laboratory of Environment Toxicology, Capital Medical University, Beijing 100069, P. R. China Department of Gastroenterology, Taizhou Hospital of Zhejiang Province, Taizhou, Zhejiang, PR China. Research Center for Biomedical Optics and Molecular Imaging, Key Laboratory of Biomedical Imaging Science and Systems, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China; Department of Hepatobiliary Surgery I, General Surgery Center, Zhujiang Hospital, Southern Medical University, Guangzhou 510280, China; Guangdong Provincial Clinical and Engineering Center of Digital Medicine, Guangzhou 510280, China; Division of Biliary Surgery, Department of General Surgery, West China Hospital, Sichuan University, Chengdu 610064, China Department of Internal Medicine‐Oncology The First Hospital of Lanzhou University Lanzhou China Cancer Research Center School of Medicine Xiamen University Fujian China Department of Gastrointestinal Surgery, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Taizhou, Zhejiang 318000, P.R. China School of Earth Science and Resources, Chang’an University, Xi’an 710054, China Department of Pharmacy, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China. Department of Chemistry, University of Cincinnati, Cincinnati, Ohio 45221, United States Xiaogan Esun Industrial Co., LTD, Xiaogan 432100, Hubei, China. School of Grain Science and Technology, Jiangsu Provincial Engineering Research Center of Grain Bioprocessing Jiangsu University of Science and Technology Zhenjiang China Department of Obstetrics and Gynecology Key Laboratory for Major Obstetric Diseases of Guangdong Province The Third Affiliated Hospital of Guangzhou Medical University Guangzhou China; Key Laboratory of Reproduction and Genetics of Guangdong Higher Education Institutes The Third Affiliated Hospital of Guangzhou Medical University Guangzhou China Department of Orthopedics, First Naval Hospital of Southern Theater Command, Zhanjiang, 524000, China Stanford University, Palo Alto, California, USA Department of Breast Disease The First Affiliated Hospital of Nanjing Medical University Nanjing China Department of Respiratory Medicine, The Second Affiliated Hospital of Soochow University, Suzhou City, Jiangsu Province, PR China Department of Pathology, Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China 1Yan’an Hospital Affiliated to Kunming Medical University, 245 Renmin East Road, Kunming City, Yunnan Province, China Division of Physics and Applied Physics, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371 Key Laboratory of Molecular Biophysics of the Ministry of Education Center for Human Genome Research College of Life Science and Technology Huazhong University of Science and Technology Wuhan China Department of Radiology, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China College of Veterinary Medicine, Yangzhou University, 12 Wenhui East Road, Yangzhou, Jiangsu Province 225009, P.R.China Department of Cardiology, Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine Department of Geriatric Medicine, Shanghai Eighth People's Hospital, Shanghai, China; Institute of Translational Medicine, and Children's Hospital Affiliated and Key Laboratory of Diagnosis and Treatment of Neonatal Diseases of Zhejiang Province, the Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, People's Republic of China; Department of Neonatal Surgery Children's Hospital, Zhejiang University School of Medicine, Hangzhou, People's Republic of China CAS Key Lab for Biomedical Effects of Nanomaterials and Nanosafety and CAS Centre for Excellence in Nanoscience; National Centre for Nanoscience and Technology of China; Beijing 100190 China Department of Orthopedics and Traumatology (Trauma and Bone-Setting), The Affiliated Hospital of Traditional Chinese Medicine of Southwest Medical University, Luzhou, Sichuan Province, China Guangdong Traditional Medical and Sports Injury Rehabilitation Research Institute, Guangdong Second Provincial General Hospital, Guangzhou, Guangdong, P.R. China Department of Traditional Chinese Medicine, Daqing Longnan Hospital, Daqing, China; Department of Urology, Changhai Hospital Guangxi Key Laboratory of Electrochemical Energy Materials, Institute of Optical Materials and Chemical Biology, School of Chemistry and Chemical Engineering, Guangxi University, Nanning, Guangxi 530004, P. R. China College of Animal Science &Veterinary Medicine, Shenyang Agricultural University, Shenyang, China Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA; Program in Developmental Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA; Structural and Computational Biology and Molecular Biophysics Graduate Program, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA International Joint Cancer Institute The Second Military Medical University, Shanghai, People's Republic of China Epithelial Cell Biology Research Center, School of Biomedical Sciences, Faculty of Medicine, Chinese University of Hong Kong, Shatin, Hong Kong College of Chemistry and Environmental Technology; Wuhan Institute of Technology; Wuhan 430073; China College of Environment and Resources, Dalian Nationalities University, 18 Liaohe West Road, Dalian 116600, China Center for Stem Cell Biology and Tissue Engineering, Sun Yat-sen University, Guangzhou, Guangdong, P.R. China; The Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Guangzhou, P.R. China Department of Pathology Chongqing University Cancer Hospital Chongqing China State Key Laboratory of Mechanical Transmissions, Chongqing University, Chongqing, China. Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China Key Laboratory of Forest Disaster Warning and Control in Universities of Yunnan Province, Southwest Forestry University, Kunming 650224, P.R. China; College of Biodiversity Conservation, Southwest Forestry University, Kunming 650224, P.R. China Department of Medical Biochemistry, Ehime University School of Medicine, Shigenobu, Japan School of Environment, Harbin Institute of Technology, Harbin 150090, China Department of Pathology Chongqing Cancer Institute/Hospital Chongqing China Center of Super-Diamond and Advanced Films (COSDAF) & Department of Physics and Materials Science, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong SAR, P. R. China Key Laboratory of Molecular Biophysics of the Ministry of Education, Center for Human Genome Research, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, China. Department of Human Genetics Baylor College of Medicine Houston Texas Department of Urology, Shanghai Changhai Hospital, Second Military Medical University, Shanghai, China. Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas Department of Cardiology, Affiliated Hospital of Jiangsu University,Zhenjiang 212001, China. Key Laboratory of Analytical Chemistry for Living Biosystems, Institute of Chemistry, The Chinese Academy of Sciences, 100190, Beijing, China; Beijing National Laboratory for Molecular Sciences, 100190, Beijing, China Faculty of Psychology, Southwest University, Chongqing, China. Stanford-Surgery Policy Improvement, Research, and Education Center, Palo Alto, California Human Genome Sequencing Center,; Department of Molecular and Human Genetics, and State Key Lab of Respiratory Disease, First Affiliated Hospital of Guangzhou Medical College, Guangzhou 510120, China. Email: chenrc@vip.163.com. Department of Gastroenterology, Shanghai University of Medicine & Health Sciences Affiliated Sixth People's Hospital South Campus, Shanghai 201499, China Email: chenruigood@126.com. Department of Pathology, Zhujiang Hospital, Southern Medical University Guangzhou, China. Beijing National Laboratory for Molecular Sciences Institute of Chemistry Chinese Academy of Sciences Beijing 100190 China; University of Chinese Academy of Sciences Beijing 100049 China College of Life Science and Technology, Huazhong University of Science and Technology (HUST), Wuhan, China Department of Molecular and Human Genetics, Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas, United States Clinical Engineering (UKCTE), Institute of Ageing and Chronic Disease; University of Liverpool; Liverpool UK The First Clinical College, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China University of California, Berkeley, Department of Materials Science and Engineering , Berkeley, CA , United States; Lawrence Berkeley National Lab, Materials Sciences Division , Berkeley, CA , United States Orthopedics department the Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University Luzhou China Department of Electrical and Electronic Engineering Southern University of Science and Technology 518055 Shenzhen P. R. China Department of Thyroid & Breast Surgery, West China Hospital, Sichuan University, Chengdu 610041, China. Scientific Research Center, China‑Japan Union Hospital of Jilin University, Changchun, Jilin 130033, P.R. China The State Key Laboratory of Bioreactor Engineering, ‡Key Laboratory for Ultrafine Materials of Ministry of Education, §Engineering Research Center for Biomedical Materials of Ministry of Education, East China University of Science and Technology, Shanghai 200237, People’s Republic of China College of Traditional Chinese Medicine, Yunnan University of Chinese Medicine, Kunming, China Shaanxi Key Laboratory of Bioresources Qinling-Bashan Mountains Bioresources Comprehensive Development CIC, School of Biological Science and Engineering, Shaanxi University of Technology, Hanzhong 723000, China State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, China; and Department of Clinical Laboratory, Beijing Tongren Hospital Affiliated to Capital Medical University, Beijing 100760, China. Department of Pharmaceutics, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou City, China Guangdong Traditional Medical and Sports Injury Rehabilitation Research Institute, Guangdong Second Provincial General Hospital, Guangzhou, Guangdong 510317, P.R. China Wuhan National Laboratory for Optoelectronics Huazhong University of Science and Technology Wuhan Hubei 430074 China Yunnan Key Laboratory of Stomatology and Department of Dental Research The Affiliated Stomatology Hospital of Kunming Medical University Kunming People's Republic of China State Key Laboratory of VirologyCollege of Life SciencesWuhan University Wuhan Hubei China Shaanxi Innolever Biotechnology Co. Ltd., Yangling, Shaanxi, China; Yangling Research Center for Immunobiological Products, Yangling, Shaanxi, China State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Provincial Engineering Technology Research Center for Chemical Drug R&D, Guizhou Medical University, Guiyang, Guizhou, China Institute of New Catalytic Materials Science, Key Laboratory of Advanced Energy Materials Chemistry (MOE), College of Chemistry, Nankai University, Tianjin 300071, China Orthopedics (Orthopedic Trauma Group), The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Luzhou, Sichuan Province, China Department of Breast Disease, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China Department of Gastrointestinal Surgery, Chaohu Hospital of Anhui Medical University, Chaohu, China Department of Pathology, Chongqing Cancer Institute/Hospital, Chongqing 400030, China. Key Lab of Separation Science for Analytical Chemistry, National Chromatographic Research and Analysis Center, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian 116023, China Medical Faculty, Kunming University of Science and Technology, Kunming, Yunnan Province, China;; The First People's Hospital of Yunnan Province, Kunming, Yunnan Province, China;; Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan Province, China; Department of General Medicine, Himi City Hospital; Department of Traditional Chinese Medicine, Union Hospital Sleep Center, Department of Respiratory Medicine, Second Affiliated Hospital, Soochow University, Suzhou 215004, China. Email: chenruigood@126.com. Yantai City Research Centre for Rural Development of Chinese Academy of Social Sciences Yantai China Department of Hepatobiliary Surgery I, General Surgery Center, Zhujiang Hospital, Southern Medical University, Guangzhou, China; Guangdong Provincial Clinical and Engineering Center of Digital Medicine, Guangzhou, China Institute of New Catalytic Materials Science, School of Materials Science and Engineering, Key Laboratory of Advanced Energy Materials Chemistry (MOE), Nankai University, Tianjin 300350, PR China Center for Drug Clinical Research, Shanghai University of Traditional Chinese Medicine, Shanghai, China Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA Breast Disease Department, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210000, PR China Department of Cardiology, Affiliated Hospital of Jiangsu University, Zhenjiang Guangxi University of Chinese Medicine Nanning China Department of Anesthesiology and Perioperative Medicine The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University Wenzhou China; Zhejiang Province Key Laboratory of Anesthesiology Wenzhou Medical University Wenzhou China Department of Pharmacology and Moores Cancer Center, University of California, La Jolla, CA, USA. Yunnan Normal University Kunming China From the Department of Medical Biochemistry, Ehime University School of Medicine (R.C., M.I., L.W., J.S., L.-J.M., T.Shiuchi, H.-W.L., T.-X.C., M.H.), Shigenobu, Ehime, Japan; and Discovery Research Laboratory, Tanabe Seiyaku Co (T.Sugaya), Osaka, Japan. Department of Neurology, The Second People's Hospital of Huaian, The Affiliated Huai an Hospital of Xuzhou Medical University, Huaian, China; College of Science, Jilin Provincial Key Laboratory of Human Health Status Identification and Function Enhancement, Changchun University, Changchun, 130022, P.R. China Department of Materials Science and Engineering, University of California, Berkeley, California 94720, United States; Materials Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States Shenzhen Institute for Quantum Science and Engineering and Department of Physics, Southern University of Science and Technology (SUSTech), Shenzhen 518055, China. International Quantum Academy, Shenzhen 518048, China. Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030-3411;; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030-3411 Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut Center for Evidence-Based Medicine, Capital Institute of Pediatrics, Beijing 100020, China Department of Pathology, Chongqing University Cancer Hospital & Chongqing Cancer Institute & Chongqing Cancer Hospital, Chongqing, China School of Basic Medical Sciences and Forensic Medicine, Hangzhou Medical College, Hangzhou, Zhejiang 310053, P.R. China Key Laboratory of Separation Sciences for Analytical Chemistry National Chromatographic R&A Center Dalian Institute of Chemical Physics Chinese Academy of Sciences Dalian China Department of General Practice, The Third People's Hospital of Chengdu, Chengdu, China Department of Respiratory Medicine, Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China (mainland) Department of Gynecology, East Hospital Affiliated to Tongji University, Shanghai 200012, China Data-Enabled Life Sciences Alliance (DELSA Global), Seattle, Washington; Department of Genetics, Stanford University, Stanford, California Department of Integrated Traditional Chinese and Western Medicine, Union Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology. 1College of Animal Science and Technology, Northwest A& F University, Yangling, China Ottawa Institute of Systems Biology, Department of Biochemistry, Microbiology and Immunology and Department of Chemistry and Biomolecular Sciences, University of Ottawa, 451 Smyth Road, Ottawa, Ontario K1H 8M5, Canada CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology of China, Beijing 100090, China Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA Institute of Tibetan medicine, University of Tibetan Medicine, Lhasa, Tibet Autonomous Region 850007, P.R. China From the Departments of Molecular and Human Genetics,6Program in Developmental Biology, and the2Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas. 1Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina. Institute of Crop Germplasm and Biotechnology, Tianjin Academy of Agricultural Sciences, Tianjin, China CAS Key Laboratory of Standardization and Measurement for Nanotechnology, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, P. R. China Key Laboratory of Ministry of Education for Medicinal Resource and Natural Pharmaceutical Chemistry, College of Life Sciences, Shaanxi Normal University, Xi'an 710119, China Department of Electrical and Electronic Engineering, South University of Science and Technology of China, Shenzhen, Guangdong 518055, P. R. China Department of General Medicine, Kanazawa Medical University, 1-1 Daigaku, Uchinada-machi, Kahoku-gun, Ishikawa 920-0293, Japan Department of Electrical and Electronic Engineering Guangdong University Key Laboratory for Advanced Quantum Dot Displays and Lighting Guangdong‐Hong Kong‐Macao Joint Laboratory for Photonic‐Thermal‐Electrical Energy Materials and Devices Southern University of Science and Technology Shenzhen 518055 P. R. China College of Chemistry and Chemical Engineering, Yunnan Normal University, Kunming 650500, Yunnan, China Centre of Excellence for Biofilm Science (CEBS), 5D Health Protection Group Ltd. Liverpool Bio‐Innovation Hub Liverpool UK CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience & Technology of China, Beijing, 100190, China Center of Super-Diamond and Advanced Films (COSDAF); Department of Materials Science and Engineering; City University of Hong Kong; Hong Kong SAR; P. R. China Human Genome Sequencing Center; Department of Molecular and Human Genetics; Baylor College of Medicine; Houston; USA 5D Health Protection Group Ltd., Centre of Excellence in Biofilm Science (CEBS), Liverpool Bio-Innovation Hub, Liverpool, United Kingdom. CAS Key Lab for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology of China, Beijing 100190, P. R. China State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, China Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham Birmingham AL USA Human Health Therapeutics Research Centre, National Research Council Canada, Ottawa, ON, Canada. CAS Key Laboratory of Separation Sciences for Analytical Chemistry, National Chromatographic R&A Center, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China Department of Morphology Laboratory, Guizhou University of Traditional Chinese Medicine, Guiyang 550025, P.R. China. Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing, China; State Key Laboratory of Respiratory Disease, Institute for Chemical Carcinogenesis, Guangzhou Medical University, Guangzhou, China Beijing National Laboratory for Molecular Sciences, Key Laboratory of Analytical Chemistry for Living Biosystems, Institute of Chemistry, The Chinese Academy of Sciences, Beijing 100190, China Department of Oral and Maxillofacial Surgery The First Affiliated Hospital of Chongqing Medical University Chongqing China Department of Environmental Health & Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA Computer Science, Hong Kong Baptist University, Kowloon Tong, China. 1Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing, China.; 7Institute for Chemical Carcinogenesis, Guangzhou Medical University, Guangzhou, China. Biomedical Research Center, The First Hospital of Kunming, Kunming, People's Republic of China. Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas;; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas;; Structural and Computational Biology and Molecular Biophysics Program, Baylor College of Medicine, Houston, Texas; and; Program in Developmental Biology, Baylor College of Medicine, Houston, Texas. Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing 100730, China. Division of Physics and Applied Physics School of Physical and Mathematical Sciences Nanyang Technological University Singapore 637371 Singapore Department of Electrical and Electronic Engineering Southern University of Science and Technology Shenzhen Guangdong 518055 P. R. China Chinese Materia Medica College, Tianjin University of Traditional Chinese Medicine, Tianjin, China State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People’s Republic of China, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agriculture Sciences, Haikou 571101, People’s Republic of China, Department of Chemistry, Yunnan University, Kunming 650091, People’s Republic of China, and Graduate School of the Chinese Academy of Sciences, Beijing 100039, People’s Republic of China Department of Electrical and Electronic Engineering Southern University of Science and Technology Shenzhen Guangdong 518055 China College of Materials Science and Engineering; Beijing University of Chemical Technology; Beijing 100029; China Department of Molecular Physiology & Biophysics, Nashville, TN, USA; Vanderbilt Genetics Institute, Vanderbilt University, Nashville, TN, USA College of Animal Science & Veterinary Medicine, Shenyang Agricultural University, Shenyang, China Department of Biology, Indiana University, 1001 East Third Street, Bloomington, Indiana 47405 1International Joint Cancer Institute, The Second Military Medical University, Shanghai, China.; 2School of Pharmacy, Liaocheng University, Liaocheng, Shandong, China. 5D Health Protection Group Ltd., Centre of Excellence in Biofilm Science, Liverpool Bio-Innovation Hub, Liverpool, United Kingdom. College of Economics, Central South University of Forestry and Technology, Changsha 410004, China. Department of Urology, Changhai Hospital, Naval Medical University, Shanghai, China. The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China Ottawa Institute of Systems Biology, Department of Biochemistry, Microbiology and Immunology and Department of Chemistry and Biomolecular Sciences, University of Ottawa, 451 Smyth Road, Ottawa, ON K1H 8M5, Canada Division of Physics and Applied Physics, School of Physical and Mathematical Sciences, Nanyang Technological University, 637371 Singapore Department of Urology Changhai Hospital The Second Military Medical University Shanghai P.R.China Shaanxi Innolever Biotechnology Co. Ltd., Yangling, Shaanxi, China; Yangling Biological Research Center of Chinese Agricultural Valley, Yangling, Shaanxi, China College of Animal Science and Technology, Northwest A&F University, Shaanxi Key Laboratory of Molecular Biology for Agriculture, Yangling, Shaanxi 712100, China Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX.; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX. Waters Corporation New Castle DE USA State Key Laboratory of Advanced technology for Materials Synthesis and Processing Wuhan University of Technology 122 Luoshi Road Wuhan 430070 P. R. China Department of Pathology, Chongqing Cancer Institute Chongqing, China. International Joint Cancer Institute, the Second Military Medical University, Shanghai, P.R. China Department of pharmaceutics, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou City, Zhejiang Province 325035, China Department of Molecular and Human Genetics; Baylor College of Medicine; Houston TX USA Guizhou Provincial Engineering Technology Research Center for Chemical Drug R&D, Guizhou Medical University, Guiyang, China Key Laboratory of Microelectronics Devices & Integrated Technology, Institute of Microelectronics of Chinese Academy of Sciences (IMECAS), Beijing 100029, China; Microelectronics Institute, University of Chinese Academy of Sciences, Beijing 100049, China Nephrology Department Northern Jiangsu People's Hospitial Yangzhou China School of Preclinical Medicine, Changchun University of Chinese Medicine, Changchun, Jilin Province 130117, China Key Laboratory of Zoological Systematics and Evolution, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China. Department of Hepatobiliary Surgery, Fujian Institute of Hepatobiliary Surgery, Fujian Medical University Union Hospital , Fuzhou, China Department of Electrical and Electronic Engineering Southern University of Science and Technology Shenzhen 518055 China Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai Key Laboratory of Clinical Laboratory Diagnostics (Ministry of Education) Chongqing Medical University Chongqing 400016 P. R. China Human Genome Sequencing Center, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX, 77030 USA Department of Chemistry and Chemical Biology, Rensselaer Polytechnic Institute, 110 8th Street, Troy, New York 12180 Institute of Pathology, Southwest Hospital, Third Military Medical University, Chongqing 400038, China. Department of Respiratory Diseases, Second Affiliated Hospital, Sun Yat-sen University, Guangzhou 510120, China. Biliary Surgical Department of West China Hospital Sichuan University Chengdu Sichuan 610064 China School of Biomedical Sciences, Faculty of Medicine The Chinese University of Hong Kong 999077 Hong Kong SAR China Department of Optoelectronic Information Engineering, Zhejiang University, Hangzhou 310027, China State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, P. R. China; College of Life Science, Nanchang University, Nanchang 330031, P. R. China; Jiangxi-OAI Joint Research Institute, Nanchang University, Nanchang 330047, P. R. China State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China; Department of Thoracic Surgery, Sun Yat-sen University Cancer Center, Guangzhou, China; Guangdong Esophageal Cancer Institute, Guangzhou, China Baylor Human Genome Sequencing Center, Houston, TX 77030, USA. Institute of Pathology, Case Western Reserve University, 2085 Adelbert Road, Cleveland, OH, 44106, La Jolla Cancer Research Foundation, La Jolla, CA, 92037, Department of Biochemistry, Fukuoka University, Fukuoka, Japan, and Roche Institute of Molecular Biology, Roche Research Center, Nutley, NJ 07110 Department of Gastroenterology, Lianyungang Oriental Hospital, The Affiliated Lianyungang Oriental Hospital of Xuzhou Medical University, The Affiliated Lianyungang Oriental Hospital of Kangda College of Nanjing Medical University, Lianyungang 222000, Jiangsu, China Department of Respiratory Medicine, The Second Affiliated Hospital of Soochow University, Suzhou 215004, China Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, United States Embryonic Self-Organization Research Group, Max Planck Institute for Molecular Biomedicine, Röntgenstrasse 20, 48149 Münster, Germany. Stephanie Jarmul, Angela Aherrera, Ana M. Rule, Pablo Olmedo, Rui Chen, and Ana Navas-Acien are with the Department of Environmental Health Sciences and Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD. School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China Key Laboratory for Regenerative Medicine of the Ministry of Education of China, School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China Department of Obstetrics and Gynecology, Peking University First Hospital, Xi’anmen Street, Beijing 100034, PR China CAS Key Laboratory of Separation Sciences for Analytical Chemistry, National Chromatographic R&A Center, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China, and Graduate School of Chinese Academy of Science, Beijing 100049, China Department of Biomedical Engineering, Rensselaer Polytechnic Institute, Troy, NY, USA School of Physical and Mathematical Sciences, Nanyang Technological University, 637371, Singapore Department of Ultrasonography; the First Affiliated Hospital of Wenzhou Medical University; Wenzhou City; China Guangdong Provincial Clinical and Engineering Center of Digital Medicine Guangzhou China; Department of Hepatobiliary Surgery, Zhujiang Hospital Southern Medical University Guangzhou China Geo-Centers, Inc., Aberdeen Proving Ground, Maryland 21010-0068, Science and Technology Corporation, Edgewood, Maryland 21040, Department of Chemistry, University of Alberta, Edmonton, Alberta T6G 2G2, and U. S. Army Edgewood Chemical Biological Center, Aberdeen Proving Ground, Maryland 21010-5424 Primary Immunodeficiency Group, Immunity and Inflammation Theme, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK. CAS Key Lab of Separation Sciences for Analytical Chemistry National Chromatographic Research and Analysis Center Dalian Institute of Chemical Physics Chinese Academy of Sciences Dalian P. R. China Key Laboratory of Hormones and Development (Ministry of Health) Metabolic Diseases Hospital & Tianjin Institute of Endocrinology Tianjin Medical University Tianjin China Department of Chemistry; Seoul National University; Seoul 151-742; South Korea Basic Medical School, Guizhou University of Traditional Chinese Medicine, Guiyang, Guizhou, 550025, China 1Department of Toxicology and Sanitary Chemistry, School of Public Health, Capital Medical University, Beijing, P.R. China.; 2Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing, P.R. China.; 3Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing, China.; 8Institute for Chemical Carcinogenesis, Guangzhou Medical University, Guangzhou, China. Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Zhejiang University School of Medicine�(Changxing Branch), Changxing, Huzhou, Zhejiang�313100, P.R.�China Key Laboratory of Colloid and Interface Chemistry (Shandong University), Ministry of Education, Shanda nanlu No. 27, Jinan, 250100, P. R. China Tianjin University; Tianjin Key Laboratory of Imaging and Sensing Microelectronic Technology Department of Neurology, Huai’an Second People’s Hospital, Huaian, Jiangsu, 223002, PR China Department of Nuclear Medicine, The First Affiliated Hospital of Naval Medical University Department of Pathology Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment Chongqing University Cancer Hospital Chongqing China State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, P.R. China; Key Laboratory of Clinical Laboratory Diagnostics (Ministry of Education), College of Laboratory Medicine, Chongqing Medical University, Chongqing 400016, P.R. China Department of Immunity and Biochemistry; Institute of Parasitic Disease; Zhejiang Academy of Medical Sciences; Hangzhou; China School of Economics and Management, China University of Petroleum, Qingdao 266580, China Department of Neurosurgery, Xiangya Hospital of Central South University, Changsha, Hunan 410078, P.R. China National University of Singapore, Optical Bioimaging Laboratory, Department of Biomedical Engineerin Centre for Innovative Cancer Research, Ottawa Hospital Research Institute, Ottawa K1H 8L6, Canada; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa K1H 8M5, Canada Department of Obstetrics and Gynecology, Peking University First Hospital, Beijing 100034, China; Department of Obstetrics and Gynecology, Beijing Tsinghua Changgung Hospital,100044, China. Nanjing National Laboratory of Microstructure, Department of Material Science and Engineering, Nanjing University, Nanjing, 210093, People’s Republic of China, and Laboratory of Mesoscopic Chemistry and Department of Polymer Science and Engineering, College of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210093, People’s Republic of China Key Laboratory of Analytical Chemistry for Living Biosystems, Institute of Chemistry Chinese Academy of Sciences, Beijing, China; Beijing National Laboratory for Molecular Sciences, 100190, Beijing, China Immunogenetics Laboratory Shenzhen Blood Center Shenzhen Guangdong China Department of Chemistry, University of Alberta, T6G 2G2, Edmonton, Alberta, Canada Division of Physics and Applied Physics, School of Physical and Mathematical Sciences, Nanyang Technological University, 21 Nanyang Link, Singapore 637371 School of Pharmacy, Chengdu Medical College, Chengdu, P. R. China International Joint Cancer Research Institute The Second Military Medical University Shanghai People's Republic of China Human Genome Sequencing Center and Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA; Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX, USA Biomedical Research Center, The Affiliated Calmette Hospital of Kunming Medical University, Kunming, China Department of Neurology, Central Hospital of Heilongjiang Farms & Land Reclamation Beian Administration, Beian Zhumadian Central Hospital, Zhumadian, Henan 463000, China. Department of Entomology, Louisiana State University AgCenter, Baton Rouge, Louisiana 70803, United States Department of Cardiology, Chinese PLA General Hospital, Beijing, China (mainland) International Joint Cancer Institute, The Second Military Medical University, Shanghai, 200433, People's Republic of China School of Public Health Capital Medical University Beijing China; Beijing Key Laboratory of Environmental Toxicology Capital Medical University Beijing China School of Public Health; University of South China; Hengyang 421001; China; CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety & CAS Center for Excellence in Nanoscience Department of Biochemistry and Molecular Biology (R.C.), Baylor College of Medicine, Houston, TX.; Department of Molecular and Human Genetics (R.C.), Baylor College of Medicine, Houston, TX.; Human Genome Sequencing Center (Yumei Li, R.C.), Baylor College of Medicine, Houston, TX. Authors' Affiliation: Cancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China Department of Respiratory Diseases Sun Yat‐sen Memorial Hospital Sun Yat‐sen University Guangzhou China Department of Medicine, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, P.R. China; Centre for Immunology and Infection, Hong Kong Science Park, Hong Kong SAR, P.R. China. Department of Obstetrics and Gynecology Peking University First Hospital Beijing 100034 China Department of Physiology, Basic Medical College, Jiamusi University, Jiamusi, Heilongjiang 154007, P.R. China College of Life Science, Dalian Nationalities University, Dalian 116600, China Department of Molecular and Human Genetics, Baylor College of Medicine , Houston, TX 77030 , USA Department of Cardiology Affiliated Hospital of Jiangsu University Zhenjiang Jiangsu P. R. China From the Department of Medical Biochemistry, Ehime University School of Medicine, Ehime, Japan. First Affiliated Hospital of Xi'an Medical University, Xi'an 710077, China. Centre of Excellence for Biofilm Science (CEBS) 5D Health Protection Group Ltd., Liverpool Bio‐Innovation Hub Liverpool UK International Joint Cancer Institute of The Second Military Medical University Shanghai, China. University of Tibetan Medicine, Lasa 850000, China. *Corresponding author, E-mail: chenruijoy@163.com. School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou City, Zhejiang Province, China. Biogas Institute of Ministry of Agriculture, Section 4-13, Chengdu, Sichuan 610041, PR China; Key Laboratory of Development and Application of Rural Renewable Energy of Ministry of Agriculture, Section 4-13, Chengdu, Sichuan, 610041, PR China State Key Laboratory of Physical Chemistry for Solid Surfaces; Department of Chemistry; College of Chemistry and Chemical Engineering; Xiamen University; Xiamen 361005 Division of Endocrinology, Diabetes and Metabolism at Baylor College of Medicine, Houston, TX, USA; Michael E. DeBakey VA Medical Center, Houston, TX, USA Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China Department of Respiratory Medicine, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215004, China; Sleep Center, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215004, China. Molecular and Human Genetics and; Human Genome Sequencing Center , Baylor College of Medicine, Houston, TX 77030 Department of Liver Surgery and Organ Transplantation, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China School of Chemistry and Chemical Engineering, Hefei University of Technology, 193 Tunxi Road, Anhui 230009, China Department of Statistics, University of Wisconsin , Madison, WI, USA Baylor College of Medicine, Houston, TX. Key Laboratory of Materials Design and Quantum Simulation and College of Science, Changchun University, Changchun, 130022, P. R. China Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA Beijing Municipal Institute of Labour Protection, Beijing Academy of Science and Technology , Beijing, China Departments of Pathology 1 ,; Program in Developmental Biology 4 , Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA Interdisciplinary Biochemistry Graduate Program and Department of Chemistry, Indiana University, 800 East Kirkwood Avenue, Bloomington, Indiana 47405 State Key Laboratory of Solidification Processing Center of Advanced Lubrication and Seal Materials Northwestern Polytechnical University Xi'an Shaanxi 710072 P. R. China Department of Molecular and Human Genetics Baylor College of Medicine Houston Texas; Human Genome Sequencing Center Baylor College of Medicine Houston Texas Department of Clinical Laboratory, The Second People’s Hospital of Futian District, Shenzhen, China CAS Key Laboratory of Design and Assembly of Functional Nanostructures, Fujian Provincial Key Laboratory of Nanomaterials, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou 350002, China; Xiamen Key Laboratory of Rare Earth Photoelectric Functional Materials, Xiamen Institute of Rare-Earth Materials, Haixi Institutes, Chinese Academy of Sciences, Xiamen 361021, China State Key Laboratory of Chemical Oncogenomics, Provincial Key Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Shenzhen Graduate School, Peking University Xili University Town, PKU Campus, F-311, Shenzhen, 518055, China Department of Obstetrics and Gynecology, Beijing Tsinghua Chang Gung Hospital, Beijing 102218, China Human genome sequencing center, Baylor College of Medicine, Houston, TX, USA. ruichen@bcm.edu. Department of molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA. ruichen@bcm.edu. State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry, Jilin University, Changchun 130012, P. R. China Collaborative Innovation Center of Tianjin for Medical Epigenetics, Key Laboratory of Hormone and Development (Ministry of Health), Metabolic Disease Hospital & Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin 300070, China Department of Orthopedics and Traumatology (Trauma and Bone-setting), The Affiliated Hospital of Traditional Chinese Medicine of Southwest Medical University, Luzhou, China School of Public Health, Wuhan University, Wuhan, P. R. China Department of Molecular and Human Genetics (L.J., R.C.), Baylor College of Medicine, Houston, Texas 77030 CAS Key Laboratory of Separation Sciences for Analytical Chemistry, National Chromatographic R&A Center, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China, and Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, University of Science & Technology of China, Hefei 230027, China Changgeng Hospital, Institute for Precision Medicine, Tsinghua University, Beijing 100084, China Institute of Biotechnology, Fujian Academy of Agricultural Sciences/Fujian Provincial Key Laboratory of Genetic Engineering for Agriculture, Fuzhou, China Department of Plastic Surgery, Renji Hospital, Shanghai Jiaotong University, Shanghai, 200127, China. Guangdong Traditional Medical & Sports Injury Rehabilitation Research Institute, Guangdong Second Provincial General Hospital, 466 Xin Gang Zhong Road, Guangzhou 510317, PR China Department of Obstetrics and Gynecology, East Hospital, School of Medicine, Tongji University, Shanghai 200120, China Department of Breast surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China Division of Physics and Applied Physics, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371, Singapore Hospital of Soochow University, Suzhou, Jiangsu, China. Department of Endocrine Breast Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, P.R. China Department of Organ Transplantation, Shanghai Changhai Hospital, Second Military Medical University, Shanghai, People’s Republic of China Key Laboratory of Analytical Chemistry for Living Biosystems Institute of Chemistry Chinese Academy of Sciences Beijing 100190 China; Beijing National Laboratory for Molecular Sciences Beijing 100190 China Department of Traditional Chinese Medicine, Union Hospital Affiliated to Huazhong University of Science and Technology, Wuhan, China; Department of General Medicine, Kanazawa Medical University, 1-1 Daigaku, Uchinada-machi, Kahoku-gun, Ishikawa 920-0293, Japan Center of Super-Diamond and Advanced Films (COSDAF), City University of Hong Kong, Kowloon, Hong Kong & City University of Hong Kong Shenzhen Research Institute, Shenzhen, Guangdong, P. R. China School of Materials Science and Engineering, Nankai University, Tianjin 300350, PR China Department of Oral & Maxillofacial Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China; Department of General Dentistry, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China College of Pharmacy Nanjing University of Chinese Medicine Nanjing China Department of Pediatrics, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930-0194, Japan. Department of Pathology, Chongqing Cancer Institute/Hospital, Chongqing, China Department of Integrated Traditional Chinese and Western Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, China Department of Breast Disease, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210000, PR China Department of Orthodontics, School and Hospital of Stomatology, Lanzhou University, Lanzhou, PR China. 1Department of Medicine and Department of Pharmacology, Comprehensive Cancer Center, Case Western Reserve University and University Hospitals of Cleveland, Cleveland, OH 44106 College of Food Science and Technology, College of Science Yunnan Agricultural University Kunming China Department of Physics and Materials Science and Centre for Functional Photonics (CFP) City University of Hong Kong 83 Tat Chee Avenue Kowloon Hong Kong SAR Department of Mechanical, Materials and Aerospace Engineering, School of Engineering Harrison Hughes Building, University of Liverpool Liverpool L69 3GH United Kingdom College of Food Science and Technology, Huazhong Agricultural University, Wuhan, Hubei 430070, China Department of Molecular Cell Biology and Toxicology, Jiangsu Provincial Key Laboratories of Human Functional Genomics and Applied Toxicology, School of Public Health, Nanjing Medical University, Nanjing, People’s Republic of China College of Information Science and Engineering, Hebei University of Science and Technology, Shijiazhuang 050018, China School of Public Health; Beijing; China; Beijing Key Laboratory of Environmental Toxicology; Capital Medical University Department of Statistics, University of Wisconsin , Madison, WI, 53715, USA Chemistry Department School of Science Honghe University Mengzi China State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing 100875, China; IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing 100875, China Key Laboratory of Cognition and Personality (Ministry of Education) and Faculty of Psychology Southwest University Chongqing China Shanghai Jiaotong University School of Communications and Information Engineering, Xi’an University of Posts and Telecommunications, Xi’an, Shanxi, China Department of Urology, Shanghai Changhai Hospital, Second Military Medical University, Shanghai 200433, China Cardiovascular Institute,; Department of Genetics, and Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China College of Life Science, Nanchang University, Nanchang 330031, P. R. China; State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, P. R. China State Key Laboratory of Functions and Applications of Medicinal Plants, School of Basic Medical Sciences, Guizhou Provincial Engineering Technology Research Center for Chemical Drug R&D, Guizhou Medical University, Guiyang, China CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Beijing, China;; Laboratory of Molecular Toxicology, State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing, China; Department of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland Departments of Neurology Shandong Long Tai Biological Technology Co. Ltd., Jinan, Shandong, China (mainland) Department of Molecular and Human Genetics, Baylor College of Medicine Houston, Texas, United States of America. Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA. Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, United States Department of Clinical Laboratory, The Second People’s Hospital of Futian District, Shenzhen, PR China Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province Kunming Institute of Zoology Chinese Academy of Sciences Kunming Yunnan 650204 China; Kunming College of Life Science University of Chinese Academy of Sciences Kunming Yunnan 650204 China School of Pharmaceutical Science Wenzhou Medical University Wenzhou Zhejiang China Vanderbilt University Department of Molecular Physiology and Biophysics, , Nashville, TN, USA Stanford-Surgery Policy Improvement Research & Education Center, Stanford University School of Medicine, Stanford, California 6Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710000, China Hainan Institute of Real World Data, The Administration of Boao Lecheng International Medical Tourism Pilot Zone, Hainan, China; Department of Biology, School of Life Sciences, Hainan University, Haikou, China Clinical Pharmacology Research Center, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing Key Laboratory of Clinical PK & PD Investigation for Innovative Drugs, No. 41 Damucang Hutong, Xicheng District, Beijing 100032, PR China Division of Endocrinology, Diabetes and Metabolism at Baylor College of Medicine , Houston, TX 77030 , USA; Michael E. DeBakey VA Medical Center Department of Medicine, , Houston, TX 77030 , USA Department of Statistics, University of Wisconsin-Madison , Madison, Wisconsin , USA Department of Oral and Maxillofacial Surgery, Sun Yat-sen Memorial Hospital of Sun Yat-sen University Department of Pediatrics, The Third Hospital of Jilin University, Changchun, Jilin 130033, China Department of Radiation Oncology, Qinghai Red Cross Hospital Department of Electrical and Electronic Engineering South University of Science and Technology Shenzhen 518055 China School of Physical and Mathematical Sciences Nanyang Technological University 50 Nanyang Avenue 639798 Singapore Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, P.R. China Department of Pharmacy Nanjing University of Chinese Medicine Nanjing 210023 China; Jiangsu Key Laboratory for Functional Substance of Chinese Medicine Nanjing 210023 China; State Key Laboratory Cultivation Base for TCM Quality and Efficacy Nanjing University of Chinese Medicine Nanjing 210023 China State Key Laboratory of Bioelectronics Southeast University Nanjing China; Key Laboratory of Environmental Medicine Engineering Ministry of Education, School of Public Health, Southeast University Nanjing China School of Materials Science and Chemical Engineering; Anhui Jianzhu University; Hefei; People's Republic of China Section of Endocrinology, Diabetes, and Metabolism, Department of Internal Medicine, Baylor College of Medicine, Houston, TX Department of Integrated Traditional Chinese and Western Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China Department of Neuroscience and Physiology, State University of New York Upstate Medical University, Syracuse, NY 13210, USA MOE Key Laboratory of Low-grade Energy Utilization Technologies and Systems, CQU-NUS Renewable Energy Materials & Devices Joint Laboratory, School of Energy & Power Engineering, Chongqing University, Chongqing 400044, People’s Republic of China Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA Department of Integrated Traditional Chinese and Western Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, China Department of Modern Mechanics University of Science and Technology of China 230026 Hefei China Department of Neurology, The Affiliated Huai’an Hospital of Xuzhou Medical University, The Second People’s Hospital of Huai'an, Huai’an, Jiangsu Province, China Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, China;; Institute for Chemical Carcinogenesis, Guangzhou Medical University, Guangzhou 511436, China Landscape Planning Laboratory, Shenyang Agricultural University, No. 120 Dongling Road, Shenyang 110161, China Department of Chemistry, University of Oregon, Eugene, Oregon 97403 Department of Molecular and Human Genetics; Baylor College of Medicine; Houston Texas; Human Genome Sequencing Center; Baylor College of Medicine; Houston Texas; Structural and Computational Biology and Molecular Biophysics Graduate Program; Baylor College of Medicine; Houston Texas; The Verna and Marrs Mclean Department of Biochemistry and Molecular Biology; Baylor College of Medicine; Houston Texas; Program in Developmental Biology; Baylor College of Medicine; Houston Texas School of Mechanical and Electronic Engineering East China Institute of Technology Nanchang 330013 P. R. China Department of Cardiovascular and Metabolic Sciences, Cleveland Clinic Lerner Research Institute, Cleveland, OH, USA Department of Urology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China College of Animal Science and Technology, Northwest A&F University, Yangling, China State Key Laboratory of Cognitive Neuroscience and Learning Beijing Normal University Beijing China; IDG/McGovern Institute for Brain Research Beijing Normal University Beijing China Institute of Science and Technology for Optoelectronic Information, Yantai University, Yantai, China. chenruisky@126.com Guizhou Provincial Engineering Technology Research Center for Chemical Drug R&D, Guiyang, China Center of Super‐Diamond and Advanced Films (COSDAF) Department of Physics and Materials Science City University of Hong Kong 83 Tat Chee Avenue Kowloon Hong Kong S. A. R. 999077 P. R. China Department of Chemistry & State Key Laboratory of Molecular Engineering of Polymers Fudan University, Fudan University, 220 Handan Road, Shanghai 200433, China Department of Respiratory Diseases, the Second Hospital Affiliated to SUN Yat-sen University, Guangzhou 510120, China. gzchenrui@163.com Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, China; State Key Laboratory of Bioelectronics, Southeast University, Nanjing 210096, China CAS Key Lab for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience & Technology of China, Beijing 100090, P. R. China Human Genome Sequencing Center, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030; College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi 712100, China State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou, Fujian 350108, China a College of Textiles, Donghua University, Shanghai 201620, P. R. China Department of Respiratory Diseases Sun Yat‐sen Memorial Hospital Sun Yat‐sen University Guangzhou People's Republic of China Department of Pathology and Immunology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA; Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA; Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA; Program in Developmental Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA; Structural and Computational Biology and Molecular Biophysics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA School of Biology and Chemical Engineering; Jiangsu University of Science and Technology; Zhenjiang China Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan 430074, China College of Bioinformatics Science and Technology, Harbin Medical University , 157 Baojian Road, Nangang District, Harbin City, Heilongjiang Province, China Department of Molecular and Human Genetics, Baylor College of Medicine , Houston , TX , USA Department of Electrical and Electronic Engineering, South University of Science and Technology of China, Shenzhen, Guangdong 518055, People’s Republic of China Division of Physics and Applied Physics; School of Physical and Mathematical Sciences; Nanyang Technological University; , Singapore Department of Genetics, Stanford University School of Medicine Palo Alto California Department of Environmental Health and Engineering, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA Department of Neurosurgery, The First Xiangya Hospital of Central South University, Changsha, Hunan 410008, P.R. China College of Arts and Sciences; Shanghai DianJi University; Shanghai 201306; People's Republic of China Ningxia Medical University, Yinchuan 750004, Ningxia, China. Department of Plastic and Reconstructive Surgery, RenJi Hospital, School of Medicine Shanghai Jiao Tong University Shanghai China 200127 Department of Integrated Traditional Chinese and Western Medicine, the Union Hospital Affiliated to Tongji Medical College of Huazhong Science and Technology University, Wuhan 430022. College of pharmacy, Guangxi University of Chinese Medicine, Nanning 530222, China College of Animal Science and Technology, National Experimental Teaching Demonstration Center of Animal Science Nanjing Agricultural University Nanjing China Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Luoyu Road 1037, Wuhan 430074, China Baylor College of Medicine Department of Chemistry University of Cincinnati Cincinnati Ohio USA Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences , Kunming, Yunnan 650223 , China; Kunming College of Life Science, University of Chinese Academy of Sciences , Kunming, Yunnan 650204 , China Department of Gastrointestinal Surgery Taizhou Hospital of Zhejiang Province Taizhou China From the Department of Cell Biology, NE10, Lerner Research Institute, Cleveland Clinic Lerner College of Medicine, OH. Sleep Center, Department of Respiratory Medicine, Second Affiliated Hospital of Soochow University, Suzhou 215004, China. Email: chenruigood@126.com. Department of Biostatistics, 3550 Terrace Street University of Pittsburgh School of Medicine Pittsburgh PA 15261 USA College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China Department of Endocrinology and Metabolism, Huai’an Hospital Affiliated to Xuzhou Medical University and Huai’an Second People’s Hospital, Huai’an, Jiangsu, China Molecular and Human Genetics (L.J., R.C.), Baylor College of Medicine, Houston, Texas 77030 Human Health Therapeutics Research Centre National Research Council Canada 100 Sussex Drive Ottawa Ontario K1A 0R6 Canada Department of Breast Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China College of Resources and Environment, Southwest University, Chongqing 400715, China. Wuhan National Laboratory for Optoelectronics Huazhong University of Science and Technology Luoyu Road 1037 Wuhan 430074 China Institute of Geriatrics (Shanghai University) Affiliated Nantong Hospital of Shanghai University (The Sixth People's Hospital of Nantong) School of Medicine Shanghai University Nantong 226011 China; Cardiac Regeneration and Ageing Lab Institute of Cardiovascular Sciences Shanghai Engineering Research Center of Organ Repair School of Life Sciences Shanghai University Shanghai 200444 China School of Marine Sciences and Biotechnology Guangxi University for Nationalities Nanning P. R. China; Guangxi Key Laboratory Cultivation Base for Polysaccharide Materials and Modifications Guangxi University for Nationalities Nanning P. R. China Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas, United States; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States Shenzhen Bionavi Life Sciences Co., Ltd., Shenzhen, Guangdong 518118, China Department of Physics and Materials Science; City University of Hong Kong; Hong Kong SAR, China; Center of Super-Diamond and Advanced Films (COSDAF); City University of Hong Kong State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People’s Republic of China, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agriculture Sciences, Haikou 571101, People’s Republic of China, and Graduate School of the Chinese Academy of Sciences, Beijing 100039, People’s Republic of China CCDC Downhole Operation Company, Chengdu610052, China Guangxi Key Laboratory for Polysaccharide Materials and Modifications, School of Marine Sciences and Biotechnology Guangxi University for Nationalities Nanning China Department of Obstetrics and Gynecology, Shanghai East Hospital, Tongji University School of Medicine, Pudong New Area, Shanghai 200120, P.R. China Key Laboratory of Marine Genetics and Breeding (Ocean University of China), Ministry of Education Qingdao China College of Marine Life Sciences Ocean University of China Qingdao 266003 China School of Clinical Medicine Chengdu University of Traditional Chinese Medicine Chengdu P.R. China 3The Fourth Clinical College of Nanjing Medical University, Nanjing, China.; 4Department of Cardiothoracic Surgery, Taixing People's Hospital, The Affiliated Taixing Hospital of Yangzhou University, Taixing, China. Department of Neonatal surgery, The Children’s Hospital Zhejiang University School of Medicine, Hangzhou, China West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu 610041, China. School of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, PR China Southern Medical University, Guangzhou, Guangdong 510515, China; Shenzhen Blood Center, Shenzhen, Guangdong 518035, China. Email: zhihui_deng@aliyun.com. Department of Nanomedicine Houston Methodist Research Institute Houston TX 77030 USA; Department of Cell and Development Biology Weill Medical College of Cornell University New York NY 10065 USA; The Third Affiliated Hospital of Guangzhou Medical University Guangzhou Medical University Guangzhou Guangdong 540150 China From the Departments of Medical Biochemistry (M.I., H.-W.L., R.C., A.I., S.O., T.S., M.H.) and Anatomy (R.H., M.S.), Ehime University School of Medicine, Shigenobu, Onsen-gun, Ehime, Japan. Key Laboratory of Jiangxi Province for Persistent Pollutants, Control and Resources Recycle, Nanchang Hangkong University, 696 Fenghe South Avenue, Nanchang 330063, China CAS Key Lab of Separation Science for Analytical Chemistry, National Chromatographic Research and Analysis Center, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China College of Bioscience and Biotechnology, Hunan Agricultural University, Changsha, China Department of Integrated Traditional Chinese and Western Medicine, Union Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430022. Department of Hepatobiliary Surgery, Zhujiang Hospital Southern Medical University 510280 Guangzhou China; Guangdong Provincial Clinical and Engineering Center of Digital Medicine 510282 Guangzhou China Beijing Jiaotong University Beijing China; Beijing Key Laboratory of Aqueous Typical Pollutants Control and Water Quality Safeguard Beijing China Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences , Kunming, YN 650223 , China Consumer Behavior Amazon.com, Inc. 333 Boren Ave N Seattle 98109 WA U.S.A. State Key Laboratory of Surface Physics and Department of Physics, Fudan University, Shanghai 200433, China; Collaborative Innovation Center of Advanced Microstructures, Nanjing University, Nanjing 210093, China Department of Breast Disease, The First Affiliated Hospital of Nanjing Medical University State Key Laboratory of Biomembrane and Membrane Biotechnology, Tsinghua University-Peking University Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China 1 Department of Hepatobiliary Surgery I, Zhujiang Hospital, Southern Medical University, Guangzhou 510280, China; Biliary Surgical Department of West China Hospital, Sichuan University, Chengdu, Sichuan 610064, China College of Science Jilin Provincial Key Laboratory of Human Health Status Identification and Function Enhancement Changchun University Changchun Jilin 130022 China State Key Laboratory of New Drug and Pharmaceutical Process, Shanghai Institute of Pharmaceutical Industry, Jingan District, Shanghai, China; State Institute of Pharmaceutical Industry, Shanghai 200437, China *Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195; Tianjin Institute of Agricultural Quality Standard and Testing Technology, Tianjin Academy of Agricultural Sciences, Tianjin 300381, China Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine Indianapolis, IN, USA ; Computer Science, Dartmouth College Hanover, NH, USA. Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, People's Republic of China Institute of Infectious Disease, School of Medicine, Xiamen University, Xiamen, China Department of Orthopaedics, Peking University Third Hospital, Beijing, China; Engineering Research Center of Bone and Joint Precision Medicine, Peking University Third Hospital, Beijing, China; Beijing Key Laboratory of Spinal Disease Research, Peking University Third Hospital, Beijing, China Center of Super-Diamond and Advanced Films (COSDAF) & Department of Materials Science and Engineering, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong SAR, P. R. China Basic Medical College in Changchun University of Chinese Medicine, Changchun, China Key Laboratory of Analytical Chemistry for Living Biosystems, Institute of Chemistry Chinese Academy of Sciences, Beijing 100190, China; Beijing National Laboratory for Molecular Sciences, Beijing 100190, Beijing, China R&D Department, Centre of Excellence in Biofilm Science (CEBS), 5D Health Protection Group Ltd, Liverpool Bio-Innovation Hub, Liverpool, UK Jiangsu Key Laboratory of Drug Design and Optimization; Department of Medicinal Chemistry; China Pharmaceutical University; Nanjing 211198; China College of Polymer Science & Engineering, and the State Key Laboratory of Polymer Materials Engineering; Sichuan University; Chengdu 610065; P. R. China Center of Super-Diamond and Advanced Films (COSDAF) & Department of Physics and Materials Science; City University of Hong Kong; Hong Kong SAR, P. R. China Department of Pharmaceutics; School of Pharmaceutical Sciences; Wenzhou Medical University; Wenzhou City; China Department of Neurosurgery, Nanhua Hospital Affiliated to Nanhua University, Hengyang, Hunan 421001, China Institute of Pharmacy Guangxi University of Chinese Medicine Nanning 530222 P. R. China; Faculty of Chinese Medicine Science Guangxi University of Chinese Medicine Nanning 530222 P. R. China Department of Molecular Physiology & Biophysics, Vanderbilt University , Nashville, TN 37232, USA; Vanderbilt Genetics Institute, Vanderbilt University , Nashville, TN 37232, USA University of Alabama at Birmingham Epidemiology Birmingham AL, USA Key Laboratory of Environmental Medicine Engineering Ministry of Education School of Public Health Southeast University Nanjing China Department of Statistics University of Wisconsin Madison Wisconsin Department of Ophthalmology and Eye Hospital, University of Leipzig, Leipzig, Germany. Faculty of Pharmacy and Pharmaceutical Sciences University of Alberta Edmonton Alberta Canada Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022. chrui1975@sina.com From the Department of Cell Biology (R.C., T.M.M.), Lerner Research Institute, Cleveland Clinic College of Medicine of Case Western Reserve University; and the Department of Chemistry (X.C., R.G.S.), Case Western Reserve University, Cleveland, Ohio. 1 Department of Respiratory Diseases, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China ; 2 Laboratory of Rehabilitation, Guangdong Provincial Hospital, Guangzhou 510055, China ; 3 Department of Respiratory Diseases, Zhujiang Hospital, Southern Medical University, Guangzhou 510280, China ; 4 Department of Clinical Laboratory, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China. State Key Laboratory of Food Science and Technology Jiangnan University Wuxi China Department of Orthopedics NO. 422 Hospital of PLA Zhanjiang China Shanghai Applied Radiation Institute, School of Environmental and Chemical Engineering, Shanghai University, Shanghai, China. Agricultural and Resource Economics College of Agriculture, Environment and Nutrition Sciences, Tuskegee University, Tuskegee, Alabama, USA Department of Pharmacology and Moores Cancer Center University of California, San Diego La Jolla CA USA Department of Genetics, Stanford University School of Medicine, Stanford, California, USA. Key Laboratory of Development and Application of Rural Renewable Energy, Ministry of Agriculture and Rural Affairs, Chengdu 610041, PR China; Biogas Institute of Ministry of Agriculture and Rural Affairs, Chengdu 610041, PR China College of Information Science and Technology, Hainan University, Haikou, China School of Materials Science and Engineering, Nankai University, Tianjin 300350, China Southern University of Science and Technology 1 Department of Electrical and Electronic Engineering, , Shenzhen 518055, China Key Laboratory of Bio-Inspired Smart Interfacial Science and Technology of Ministry of Education, School of Chemistry, Beihang University, Beijing 100191, P. R. China IDG/McGovern Institute for Brain Research, Department of Psychology, Beijing Normal University State Key Laboratory of Cognitive Neuroscience and Learning & , Beijing 100875 , China Department of Endocrine and Breast Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China; Department of Thyroid and Breast Surgery, The Affiliated Hospital of Zunyi Medical University, Zunyi, 563000 Guizhou, China Graduate School Medical College of Nanchang University Nanchang China; Jiangxi Key Laboratory of Translational Research for Cancer Jiangxi Clinical Research Center for Cancer Jiangxi Cancer Hospital, The Second Affiliated Hospital of Nanchang Medical College Nanchang China Key Laboratory for Green Organic Synthesis and Application of Hunan Province, Key Laboratory of Environmentally Friendly Chemistry and Application of Ministry of Education, College of Chemistry, Xiangtan University, Xiangtan 411105, China Key Laboratory of Environmental Medicine Engineering School of Public Health Southeast University Nanjing China Department of Plastic and Reconstructive Surgery Ren Ji Hospital School of Medicine Shanghai Jiaotong University Shanghai China School of Public Health, Wuhan University, Wuhan, P.R. China Department of Pharmaceutics, School of Pharmaceutical Sciences Wenzhou Medical University Wenzhou Zhejiang Province 325035 China Department of Materials Science and Engineering, University of California, Berkeley, Berkeley, CA, USA.; Materials Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA. Department of Thoracic Surgery, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Nanjing Medical University Affiliated Cancer Hospital, Jiangsu Key Laboratory of Molecular and Translational Cancer Research, Nanjing, Jiangsu 210009, P.R. China From the Department of Medical Biochemistry (J.S., M.I., H.N., L.W., R.C., M.H.) and the Second Department of Internal Medicine (J.S., M.H., K.H.), Ehime University School of Medicine, Ehime, Japan; and Discovery Research Laboratory (T.S.), Tanabe Seiyaku Co, Osaka, Japan. Department of Orthopaedics; The First Affiliated Hospital of Wenzhou Medical University; Wenzhou; China; Department of Pharmaceutics Department of Dentistry, Tongji Hospital of Huazhong University of Science and Technology, Wuhan 430030, China. General Electric Healthcare Milwaukee Wisconsin USA Department of Gynecology, Shanghai United Family Hospital, Shanghai 200120, China Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX; Sun Yat‐sen Memorial Hospital Sun Yat‐sen University Guangzhou China Key Laboratory of Physical Fitness and Exercise Rehabilitation of Hunan Province, College of Physical Education, Hunan Normal University, Changsha 410012. 1 Department of Molecular Physiology and Biophysics, Vanderbilt University, TN, 37221, USA, 2Quantitative Biomedical Research Center, University of Texas Southwestern Medical Center, Dallas, TX, USA, 3Center for Quantitative Sciences, Vanderbilt University, TN, 37221, USA, 4Department of Medicine, University of Chicago, Chicago, IL, USA, 5Department of Psychiatry, University of Illinois at Chicago, Chicago, IL, USA, 6Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH, USA and 7Department of Pediatrics, University of Pittsburgh, Pittsburgh, PA, USA College of Life Science and Technology Huazhong University of Science and Technology (HUST) Wuhan China Department of Urology, Shanghai Changhai Hospital, Second Military Medical University; Department of Urology, Renji Hospital, Shanghai Jiao Tong University School of Medicine Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030-3411, USA; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030-3411, USA. Electronic address: ruichen@bcm.edu. School of Biological Science and Engineering, Shaanxi University of Technology, Hanzhong, China School of Clinical Medicine Tsinghua University Beijing China; Department of Obstetrics and Gynaecology School of Clinical Medicine Beijing Tsinghua Changgung Hospital Tsinghua University Beijing China Department of Critical Care Medicine, Beijing Tsinghua Changgung Hospital, Beijing 102218, P.R. China Department of Pharmacy, Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing University of Chinese Medicine, Nanjing, PR China; Chongqing Key Laboratory of Neurology, Department of Neurology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China Department of Chemistry, University of Alberta, E3-44 Chemistry Building, T6G 2G2, Edmonton, Alberta, Canada Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region Nanning China Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.; Department of Biochemistry, Baylor College of Medicine, Houston, TX 77030, USA. Department of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA Department of Molecular and Human Genetics; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA Department of Oral and Maxillofacial Surgery Sun Yat‐sen Memorial Hospital Sun Yat‐sen University Guangzhou Guangdong 510120 P. R. China College of Liberal Arts and Science, National University of Defense Technology, Changsha 410073, China Department of Molecular and Human Genetics Baylor College of Medicine Houston TX USA National Space Science Center Chinese Academy of Sciences Beijing 100190 P. R. China; University of Chinese Academy of Sciences Beijing 100049 P. R. China Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA; Department of Cardiovascular Medicine Wuhan Third Hospital & Tongren Hospital of Wuhan University Wuhan Hubei China Clinical Engineering; Institute of Ageing and Chronic Disease; University of Liverpool; Liverpool, UK *Department of Respiratory Diseases, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China; Department of Breast Surgery, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China Department of Respiratory Medicine Sun Yat‐Sen Memorial Hospital Guangzhou Guangdong P.R. China Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing, China,; State Key Laboratory of Bioelectronics, Southeast University, Nanjing, China School of Health Sciences Department of Stomatology, Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University), Haikou, P.R. China. Department of Biochemical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China Department of Immunity & Biochemistry, Institute of Parasitic Disease, Zhejiang Academy of Medical Sciences, No.182, Road Tianmushan, 310013, Hangzhou, China Key Laboratory of Analytical Chemistry for Living Biosystems, Institute of Chemistry, The Chinese Academy of Sciences, Beijing 100190, China and Beijing National Laboratory for Molecular Sciences, Beijing 100190, China Department of Pediatrics, China‑Japan Union Hospital of Jilin University, Changchun, Jilin 130033, P.R. China Union Hospital Affiliated to Tongji Medical College of Huazhong Science and Technology University, Wuhan 430022. Human Genome Sequencing Center, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States State Key Laboratory of Photocatalysis on Energy and Environment; Fuzhou University; Fuzhou 350002; China Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA; Structural and Computational Biology and Molecular Biophysics Graduate Program, Baylor College of Medicine, Houston, TX, USA Human Genome Sequencing Center Baylor College of Medicine Houston TX USA; Department of Molecular and Human Genetics Baylor College of Medicine Houston TX USA; Program in Developmental Biology Baylor College of Medicine Houston TX USA Department of Plastic Surgery Renji Hospital School of Medicine Shanghai Jiao Tong University Shanghai 200127 P.R. China Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States Institute of New Catalytic Materials Science; School of Materials Science and Engineering; Key Laboratory of Advanced Energy Materials Chemistry (MOE); Nankai University; Tianjin 300350 Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, China Department of Integrative Chinese and Western Medicine, Union Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology. School of Aerospace Engineering, Xiamen University, Xiamen 361102, China College of Food Science and Technology, Nanjing Agriculture University, 1 Weigang, Nanjing 210095, China Key Laboratory of Separation Sciences for Analytical Chemistry, National Chromatographic R&A Center, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China; Graduate School of Chinese Academy of Science, Beijing 100049, China Department of Breast Disease the First Affiliated Hospital of Nanjing Medical University Nanjing Jiangsu China Department of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, People’s Republic of China; Institute of Brain Science, Harbin Medical University, Harbin, Heilongjiang Province, People’s Republic of China; The Chinese-German Center of Academic Excellence in Neuroscience, Harbin, Heilongjiang Province, People’s Republic of China Embryonic Self-Organization Research Group, Max Planck Institute for Molecular Biomedicine, Röntgenstraße 20, 48149 Münster, Germany. College of Animal Science and Technology Nanjing Agricultural University Nanjing China Department of Forensic Medicine, Guangdong Medical University , Dongguan 523808, China Department of Oral and Maxillofacial Surgery Sun Yat‐sen Memorial Hospital, Sun Yat‐sen University Guangzhou China Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030 Shenzhen Key Laboratory for Advanced Quantum Dot Displays and Lighting, Department of Electrical & Electronic Engineering, Southern University of Science and Technology, Shenzhen 518055, China Beijing Laboratory of Molecular Science, Joint Laboratory of Polymer Science and Materials, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China Center for Drug Clinical Evaluation Shanghai University of Traditional Chinese Medicine Shanghai China Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA Human Genome Sequencing Center and Department of Molecular and Human Genetics Baylor College of Medicine Houston Texas USA; Department of Biochemistry and Molecular Biology Baylor College of Medicine Houston Texas USA Embryonic Self-Organization Research Group, Max Planck Institute for Molecular Biomedicine Department of Oncology, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan China; Department of Hepatobiliary Surgery The First Affiliated Hospital of Xi'an Jiaotong University Xi'an China The Third Affiliated Hospital of Changchun University of Traditional Chinese Medicine, Changchun, China Particles and Catalysis Research Laboratory, School of Chemical Engineering, The University of New South Wales, Sydney, New South Wales 2052, Australia Department of Oncology The Third Affiliated Hospital of Soochow University Changzhou China Key Laboratory of Environmental Medicine Engineering,Ministry of Education,School of Public Health,Southeast University,Nanjing,China; Beijing Key Laboratory of Environmental Toxicology,School of Public Health,Capital Medical University,Beijing,China; State Key Laboratory of Bioelectronics,Southeast University,Nanjing,China Department of Thyroid and Breast, West China Hospital of Sichuan University, Chengdu, China. Human Genome Sequencing Center (R.C., Yumei Li, S.K.), Baylor College of Medicine, Houston, TX. Capital Medical University, Beijing Ophthalmology & Visual Sciences Key Lab, Beijing, China. From the Department of Molecular and Cellular Biology, Division of Medical Biochemistry and Cardiovascular Biology, Ehime University School of Medicine, Shitsukawa, Tohon, Ehime, Japan. From the Department of Medical Biochemistry (L.W., M.I., H.N., R.C., J.S., M.H.), Ehime University School of Medicine, Ehime, Japan; the Department of Geriatric Medicine (M.A.), Kyorin University School of Medicine, Tokyo, Japan; and MG Consulting Co (M.d.G.), Rossemaison, Switzerland. Department of Urology Changhai Hospital Naval Medical University Shanghai China Geo-Centers, Inc., Aberdeen Proving Ground, Maryland 21010-0068, U.S. Army Edgewood Chemical Biological Center, Aberdeen Proving Ground, Maryland 21010-5424, Department of Chemistry, University of Alberta, Edmonton, Alberta T6G 2G2, Canada, and Department of Biological Sciences, University of Alberta, Edmonton, Alberta T6G 2N8, Canada Key Laboratory of Separation Sciences for Analytical Chemistry, National Chromatographic R&A Center, Dalian Institute of Chemical Physics, The Chinese Academy of Sciences, Dalian 116023, China, and The Second Affiliated Hospital of Dalian Medical University, Dalian 116027, China Department of Respiratory Medicine, The Second Affiliated Hospital of Suzhou University, Suzhou, Jiangsu Department of Pharmacology and Moores Cancer Center, University of California, San Diego, La Jolla, California 92093, USA;, , , Veterans Affairs North Texas Health Care System, Department of Medicine, 4500 South Lancaster Road, Dallas, TX 75216, USA.; University of Texas Southwestern Medical Center at Dallas, Department of Internal Medicine, 5323 Harry Hines Boulevard, Dallas, TX 75390–8573, USA. MOE Key Laboratory of Low-Grade Energy Utilization Technologies and Systems, School of Energy and Power Engineering, Chongqing University 1 , Chongqing 400044, China Department of Spine Surgery The Second Affiliated Hospital of Harbin Medical University Harbin People's Republic of China Department of Organ Transplantation Shanghai Changhai Hospital Shanghai China Beijing Key Laboratory of Occupational Safety and Health, Beijing Municipal Institute of Labour Protection, Beijing, China Department of Pharmacy, Shanghai Chest Hospital, Shanghai Jiao Tong University , Shanghai , China Department of Pathology, Chongqing Cancer Institute, Chongqing 400030, China Department of Cardiology, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu, China Division of Physics and Applied Physics; School of Physical and Mathematical Sciences; Nanyang Technological University; Singapore Gansu Provincial Center for Disease Control and Prevention, Lanzhou 730000, China. Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology Huazhong University of Science and Technology Wuhan China Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas, United States 3Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States 5Structural and Computational Biology & Molecular Biophysics, Department of Kidney internal medicine, Clinical Medical College, Yangzhou University, Yangzhou, China Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing, Jiangsu, 210009, China; Coordinate of State Ministry TB Puntland Government, Somalia; State Key Laboratory of Bioelectronics, Southeast University, Nanjing 210096, China Clinical Pharmacology Research Center, Peking Union Medical College Hospital, Chinese Academy of Medical Science, Beijing 100730, China. Breast Disease Department, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210000, P.R. China Biomedical Research Center The First Hospital of Kunming (the Affiliated Calmette Hospital of Kunming Medical University) Kunming China School of Chemistry and Chemical Engineering, State Key Laboratory of Metal Matrix Composites, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China Key Laboratory of Green Chemistry and Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu, Sichuan 610064, P. R. China College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China; From the Department of Neurosurgery, Pennsylvania State University College of Medicine, Hershey (R.J., G.L.); and Department of Neurosurgery (R.C., R.J., G.L.) and the Department of Molecular and Cellular Physiology (A.Y.X., G.L., D.N.G.), Louisiana State University Health Sciences Center, Shreveport. Department of Molecular and Human Genetics Human Genome Sequencing Center Baylor College of Medicine Houston TX 77030 USA Department of Computer Science, Tufts University, Medford, Massachusetts 02155, United States Department of General Medicine, Kanazawa Medical University; Department of Traditional Chinese Medicine, Union Hospital Affiliated to Huazhong University of Science and Technology Department of Endocrine and Breast Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, P.R. China Department of Genetics Baylor College of Medicine Houston TX USA; Department of Biochemistry Baylor College of Medicine Houston TX USA Department of Chemistry, Institutes of Biomedicine Sciences, State Key Laboratory of Molecular Engineering of Polymers, and Collaborative Innovation Center of Chemistry for Energy Materials, Fudan University, 220 Handan Road, Shanghai 200433, P.R. China Department of Physics and Key Laboratory of Artificial Micro‐ and Nano‐structures of Ministry of Education Hubei Nuclear Solid Physics Key Laboratory and Center for Ion Beam Application Wuhan University Wuhan 430072 P. R. China Department of Clinical Laboratory, The Second People's Hospital of Futian District, Shenzhen, Guangdong 518049, P.R. China State Key Laboratory of Subtropical Silviculture, School of Forestry and Biotechnology, Zhejiang A&F University, Hangzhou 311300, China. Attending Doctor, Department of Ultrasound, the Second Affiliated Hospital of Guangzhou Medical University, China Yunnan Key Laboratory of Stomatology Kunming Medical University Kunming Yunnan PR China; Department of Dental Research The Affiliated Stomatology Hospital of Kunming Medical University Kunming Yunnan PR China Department of Oncology, Jiujiang No. 1 People's Hospital, Jiujiang, Jiangxi 332000, P.R. China Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health Southeast University Nanjing China Guangdong Traditional Medical and Sports Injury Rehabilitation Research Institute Guangdong NO. 2 Provincial People's Hospital Guangdong Guangzhou China Department of Pharmacology and Cancer Biology Duke University Durham NC USA Ottawa Institute of Systems Biology and Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada, K1H 8M5 Human Genome Sequencing Center Baylor College of Medicine Houston Texas Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030 College of Chemistry and Chemical Engineering, Yunnan Normal University, 650500, Kunming, China Department of Laboratory Medicine, Beijing Tong-Ren Hospital, Capital Medical University , Beijing, China Department of Molecular & Human Genetics Baylor College of Medicine Houston TX USA Department of Immunology, Basic Medical Sciences, Medical College, Xiamen University, Xiamen, Fujian 361102, P.R. China Biotechnology Research Institute, Tianjin Academy of Agricultural Sciences, Tianjin, China State Key Lab of Modern Optical Instrumentation, Centre for Optical and Electromagnetic Research, College of Optical Science and Engineering, International Research Center for Advanced Photonics, Zhejiang University, Hangzhou 310058, China School of Chemistry and Chemical Engineering, Hefei University of Technology, Hefei 230009, China Department of Traditional Chinese Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China Research Center for Swine Diseases, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China School of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, P.R. China Immunogenetics Laboratory, Shenzhen Blood Center , Shenzhen, Guangdong, P. R. China Department of Gynecology, Third Affiliated Hospital of Xinjiang Medical University Urumqi, China. Integrated Traditional Chinese Medicine and Western Medicine Department, Union Hospital Affiliated to Tongji Medical College of Huazhong Science and Technology University, Wuhan 430022. Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, China; State Key Laboratory of Bioelectronics, Southeast University, Nanjing, 210096, China Department of Neurology, Soochow University, Suzhou, China; Department of Neurology, The Second People’s Hospital of Huai’an and The Affiliated Huai’an Hospital of Xuzhou Medical University, Huai’an, China College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang, China Division of Physics and Applied Physics, School of Physical and Mathematical Sciences Nanyang Technological University Singapore 637371 Singapore Beijing Key Laboratory of Occupational Safety and Health, Beijing Municipal Institute of Labor Protection, Beijing 100054, China College of Computer and Information Science, Southwest University, Chongqing, China Department of Nuclear Medicine; Changhai Hospital of Shanghai, Shanghai 200433, P.R. China Department of Molecular Physiology and Biophysics, Vanderbilt University , Nashville, 37240 TN, USA; Vanderbilt Genetics Institute, Vanderbilt University , Nashville, 37240 TN, USA Department of Anesthesiology Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China State Key Laboratory of Natural Medicines and Jiang Su Key Laboratory of Drug Design and Optimization, Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing, China Department of Orthopedics Jiangnan University Medical Center Wuxi China Authors' Affiliations: 1School of Pharmacy, Shanghai Jiao Tong University; 2International Joint Cancer Research Institute, The Second Military Medical University; and 3National Engineering Research Center of Antibody Medicine, State Key Laboratory of Antibody Medicine and Targeting Therapy, Shanghai, PR China Key Laboratory of Drinking Water Science and Technology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China; State Key Laboratory of Environmental Aquatic Chemistry, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China Department of Gynecology and Obstetrics The First Affiliated Hospital of Xi’an Medical University Xi’an China Centre of Excellence in Biofilm Science and Technologies (CEBST), 5D Health Protection Group Ltd Liverpool Bio‐Innovation Hub Liverpool UK Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas, United States 2Structural and Computational Biology & Molecular Biophysics Graduate Program, Baylor College of Medicine, Houston, Texas, United States 4Department of Molecular and Department of Materials Science and Engineering, National University of Singapore, Singapore 117574 Key Laboratory of Photochemistry, Beijing National Laboratory for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China; University of Chinese Academy of Sciences, Beijing 100049, China Department of Gynaecology, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, China |
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