http://rdf.ncbi.nlm.nih.gov/pubchem/author/MD5_c8701da856e81bef255b7d39ab9f9092
Outgoing Links
Predicate | Object |
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family-name | Bin Liu Liu |
name | Bin Liu |
given-name | Bin |
organization-name | Department of Orthopedics Guangdong General Hospital, Guangdong Academy of Medical Sciences Guangzhou Guangdong China School of Chemistry and Chemical Engineering, Liaocheng University, Liaocheng 252059, China; Key Laboratory of Colloid and Interface Chemistry (Ministry of Education), School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, China Key Laboratory of Colloid and Interface Chemistry (Ministry of Education); Shandong University; Jinan 250100; P. R. China TEDA Institute of Biological Sciences and Biotechnology, Nankai University, 23 Hongda Street, TEDA, Tianjin 300457, PR China 1Departments of Anesthesia and Pharmaceutical Chemistry,; 2Comprehensive Cancer Center, and School of Chemical and Biomedical Engineering Nanyang Technological University 62 Nanyang Drive Singapore 637459 Singapore State Key Laboratory of Chemical Resource Engineering College of Chemistry Beijing University of Chemical Technology Beijing 100029 China Key Laboratory of Superlight Materials and Surface Technology Ministry of Education College of Materials Science and Chemical Engineering Harbin Engineering University Harbin 150001 P. R. China Department of Genetics , The University of Texas MD Anderson Cancer Center, Houston, Texas 77030; Center for Genetics and Genomics , Department of Genetics, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030 College of Biology and the Environment, Nanjing Forestry University, Nanjing, Jiangsu, China; Management Bureau of Dafeng Milu National Nature Reserve, Yancheng, Jiangsu, China Department of Chemistry, Washington University, St. Louis, Missouri 63130 Department of Nuclear Medicine, West China Hospital, Sichuan University, Chengdu 610041, China. State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, No. 2699 Qianjin Avenue, Changchun 130012, China International School of Information Science & Engineering (DUT-RUISE), Dalian University of Technology, Dalian, China;; Key Lab of Ubiquitous Network and Service Software of Liaoning Province, Dalian University of Technology, Dalian, China; Department of Urinary Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, P. R. China Department of Spine Surgery The Third Affiliated Hospital of Sun Yat‐sen University Guangzhou 510630 China 3Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Department of Orthopedics Liaocheng Second People's Hospital Linqing City Shandong Province China Department of Neurology, Ann Romney Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts 02115, United States School of Stomatology of Lanzhou University; Lanzhou 730000; China State Key Laboratory for Superlattices and Microstructures, Institute of Semiconductors, Chinese Academy of Sciences, Beijing 100083, P. R. China.; Wuhan National Laboratory for Optoelectronics (WNLO) and College of Optical and Electronic Information, Huazhong University of Science and Technology (HUST), Wuhan 430074, P. R. China. Department of Chemical Engineering Kansas State University 1005 Durland Hall Manhattan Kansas 66506 Department of General Surgery The Secondary Hospital of Tianjin Medical University Tianjin China Department of Rheumatology, Affiliated Hospital of Qingdao University Medical College, 266053, China Department of Orthopedic Lishui People's Hospital (The Sixth Affiliated Hospital of Wenzhou Medical University Lishui China School of Computer Science and Technology, Harbin Institute of Technology Shenzhen Graduate School, Shenzhen, Guangdong, China; Key Laboratory of Network Oriented Intelligent Computation, Harbin Institute of Technology Shenzhen Graduate School, Shenzhen, Guangdong, China; Gordon Life Science Institute, Boston, Massachusetts, USA International School of Information Science and Engineering (DUT‐RUISE) Dalian University of Technology Dalian China; Key Lab of Ubiquitous Network and Service Software of Liaoning Province Dalian University of Technology Dalian China Department of General Surgery, The Secondary Hospital of Tianjin Medical University, Tianjin 300211, P.R. China Department of Chemical Engineering, Laboratory for Advanced Materials, Tsinghua University, Beijing, 100084, P. R. China 5Department of Anesthesia, University of California, San Francisco, San Francisco, California.; 11UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, California. School of Chinese Pharmacy; Beijing University of Chinese Medicine; Beijing 100102 China Institute of Nano Biomedicine and Engineering, Shanghai Engineering Research Centre for Intelligent Diagnosis and Treatment Instrument, Department of Instrument Science and Engineering, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, 800 Dongchuan RD, Shanghai 200240, PR China; National Center for Translational Medicine, Collaborative Innovational Center for System Biology, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, PR China Department of Hand and Foot Surgery The First Hospital of Jilin University Changchun China Guangzhou Institute of Cardiovascular Disease Guangdong Key Laboratory of Vascular Diseases State Key Laboratory of Respiratory Disease the Second Affiliated Hospital Guangzhou Medical University Guangzhou China Department of Neurology, Jining NO.1 People’s Hospital Guangzhou Institute of Cardiovascular Disease, Guangdong Key Laboratory of Vascular Diseases, State Key Laboratory of Respiratory Disease, The Second Affiliated Hospital of Guangzhou Medical University Guangzhou Guangdong China Department of Gastrocolorectal Surgery, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China School of Pharmaceutical Sciences Liaoning University Shenyang China; Liaoning Provincial Engineering Research Center for Natural Products Pharmaceutical Shenyang China; Liaoning Provincial Key Laboratory of New Drug R&D Shenyang China Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.; Key Laboratory of Organ Transplantation, Ministry of Education, Ministry of Public Health, Chinese Academy of Medical Sciences, China. School of Chemical and Biomedical Engineering Nanyang Technological University Singapore 637459 Singapore Department of Chemical and Biomolecular Engineering National University of Singapore Singapore 117576; Institute of Materials Research and Engineering Agency for Science, Technology and Research 3 Research Link Singapore 117602 Key Laboratory of Protein Modification and Tumor, Hubei Polytechnic University School of Medicine, Huangshi, Hubei, PR China Department of Oral Biology, College of Stomatology, Fourth Military Medical University, Xi'an 710032, China. kqyljd@fmmu.edu.cn Tsinghua University; Tianjin University of Technology Key Laboratory of Flexible Electronics (KLoFE) and Institute of Advanced Materials (IAM), Nanjing Tech University (Nanjing Tech), 30 South Puzhu Road, Nanjing 211816, China TEDA Institute of Biological Sciences and Biotechnology, Nankai University, 23 Hongda Street, TEDA, Tianjin 300457, PR China; The Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, 23 Hongda Street, TEDA, Tianjin 300457, PR China Shaanxi Key Laboratory for Advanced Energy Devices; Shaanxi Engineering Laboratory for Advanced Energy Technology; Key Laboratory of Macromolecular Science of Shaanxi Province; School of Materials Science and Engineering, Shaanxi Normal University, Xi’an, 710119, China Department of Occupational Health and Occupational Disease, College of Public Health, Zhengzhou University, Zhengzhou, China Department of Mechanical and Aerospace Engineering, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong SAR999077, People’s Republic of China State Key Laboratory of Powder Metallurgy, Central South University, Changsha 410083, China The Key Laboratory of Cardiovascular Remodeling and Function Research Chinese Ministry of Education and Chinese Ministry of Public Health Department of Cardiology Qilu Hospital of Shandong University Jinan China Department of Assisted Reproduction, Xinhua Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200092, People’s Republic of China Authors' Affiliations: 1Cancer Research Institute; 2Department of Pancreas and Hepatobiliary, Pancreatic Cancer Institute; 3Department of Pathology, Fudan University Shanghai Cancer Center; 4Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China; and 5Division of Molecular Bioregulation, Cancer Microenvironment Research Program, Cancer Research Institute, Kanazawa University, Kanazawa, Japan Department of Chemical and Biomolecular Engineering; National University of Singapore; Singapore Department of Genetics, the University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Center for Cancer Genetics and Genomics, the University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA Key Laboratory of Advanced Ceramics and Machining Technology (Ministry of Education), School of Materials Science and Engineering, Tianjin University, Tianjin 300072, China Management office of Dafeng Milu National Nature Reserve, Yancheng, 224136, China Department of Otolaryngology, First Affiliated Hospital, China Medical University, Shenyang 110001. liubincmu@163.com Department of Endodontics and Operative Dentistry Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai Key Laboratory of Stomatology Shanghai China; Center for Dental Research Loma Linda University School of Dentistry CA USA State Key Laboratory of Cotton Biology Key Laboratory of Plant Stress Biology College of Life Sciences Henan University Kaifeng China Center for Molecular Systems and Organic Devices (CMSOD), Key Laboratory for Organic Electronics and Information Displays & Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing University of Posts & Telecommunications, 9 Wenyuan Road, Nanjing 210023, China Department of Neurosurgery, Zaozhuang Hospital of Zaozhuang Coal Mining Group, Zaozhuang, Shangdong, China (mainland) Vollum Institute for Advanced Biomedical Research, L474, Oregon Health Sciences University, 3181 S. W. Sam Jackson Park Road, Portland, Oregon 97201 Key Laboratory of Nutrition and Metabolism Institute for Nutritional Sciences Shanghai Institutes for Biological Sciences Chinese Academy of Sciences The Graduate School of the Chinese Academy of Sciences Shanghai China Rice Research Institute Guangdong Academy of Agricultural Sciences Guangzhou 510640 China; Guangdong Provincial Key Laboratory of New Technology in Rice Breeding Guangdong Academy of Agricultural Sciences Guangzhou 510640 China Center of Statistical Research, School of Statistics, Southwestern University of Finance and Economics, Chengdu, China Department of Pharmaceutical Chemistry, College of Pharmacy, Rutgers, The State University of New Jersey, 160 Frelinghuysen Road, Piscataway, New Jersey 08854-8020 Department of Orthopaedics, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, China Institute of Organ Transplantation Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China; Key Laboratory of Organ Transplantation Ministry of Education Wuhan China; NHC Key Laboratory of Organ Transplantation Wuhan China; Key Laboratory of Organ Transplantation Chinese Academy of Medical Sciences Wuhan China Department of Radiology, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China School of Chinese Pharmacy Beijing University of Chinese Medicine Beijing 100102 China Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of the Ministry of Education Shaanxi Key Laboratory of Physico-Inorganic Chemistry College of Chemistry & Materials Science Northwest University Xi'an 710069 P.R. China Department of Chemical Engineering; Kansas State University; Manhattan; USA School of Material Science and Engineering; Jiangxi University of Science and Technology; Ganzhou 341000; P. R. China Department of Urology Surgery, The Fourth Hospital of Hebei Medical University, Hebei, PR China. Department of General Surgery, The First Affiliated Hospital, Anhui Medical University, Hefei 230032, China. anyiliubin@yahoo.com.cn Department of Anesthesia and Perioperative Cave, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA 94110, USA Department of Clinic, Inner Mongolia Medical University People’s Hospital, Hohhot 010020, Inner Mongolia, People’s Republic of China. Chongqing University Key Laboratory of Precision Nutrition and Food Quality Research Center of Food Colloids and Delivery of Functionality College of Food Science and Nutritional Engineering China Agricultural University Beijing 100083 P. R. China; Department of Nutrition and Health China Agricultural University Beijing 100091 P. R. China Department of Chemical Engineering, Kansas State University, Manhattan, Kansas 66506, United States Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore 117585; Institute of Materials Research and Engineering (Astar), 3 Research Link, Singapore 117602 Key Laboratory of Superlight Materials and Surface Technology; Ministry of Education; College of Material Sciences and Chemical Engineering; Harbin Engineering University; Harbin Department of Burn, Plastic and Cosmetic Surgery, Xi’an Central Hospital, Xi’an Jiaotong University, Xi’an, China Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering Key Laboratory of Green Pesticide and Agricultural Bioengineering Ministry of Education, Guizhou University Huaxi District Guiyang 550025 P. R. China; Division of Chemistry and Biological Chemistry School of Physical and Mathematical Sciences Nanyang Technological University Singapore 637371 Singapore Department of Chemistry and Waterloo Institute for Nanotechnology, University of Waterloo, 200 University Avenue West, Waterloo, Ontario, Canada N2L 3G1 College of Plant Protection, Engineering and Technology Centers of Biopesticide in Shaanxi Northwest A&F University Yangling China Faculty of Mechanical and Electronic Information, China University of Geosciences (Wuhan) 1 , Wuhan 430074, China Singapore−MIT Alliance and Department of Chemical and Biomolecular Engineering, National University of Singapore, 10 Kent Ridge Crescent, Singapore 119260 Department of Hand Surgery, First Hospital of Jilin University, Changchun Jilin 130031, PR China. liubinzhlr@yahoo.com.cn School of Computer Science and Technology, Harbin Institute of Technology Shenzhen Graduate School, Shenzhen, Guangdong, China School of Mathematics and Information Science, Nanchang Hangkong University, Nanchang, China Key Laboratory of Superlight Materials & Surface Technology, Ministry of Education, College of Materials Science and Chemical Engineering Harbin Engineering University Harbin 150001 P. R. China School of Nuclear Science and Technology, Lanzhou University, Lanzhou, Gansu, China Department of Physiology and Cell Biology and the Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio Key Laboratory of Advanced Ceramics and Machining Technology (Ministry of Education) Tianjin Key Laboratory of Composite and Functional Materials School of Materials Science and Engineering Tianjin University Tianjin 300072 China Department of Neurosurgery, Central Hospital of Cangzhou, Cangzhou, Hebei 061001, P.R. China Department of Nuclear Medicine, West China Hospital, Sichuan University, Chengdu, China. State Key Laboratory for Manufacturing Systems Engineering, Xi’an Jiaotong University, Xi’an 710054, China; Shaanxi Key Laboratory of Intelligent Robots, Xi’an Jiaotong University, Xi’an 710049, China Eye Institute and Affiliated Xiamen Eye Center of Xiamen University, School of Medicine, Xiamen University, Xiamen, China; Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Xiamen, Fujian, China; Fujian Key Laboratory of Ocular Surface & Corneal Diseases (affiliated Xiamen Eye Center of, Xiamen University), Xiamen, Fujian, China; Xiamen Municipal Key Laboratory of Ocular Surface & Corneal Diseases, Xiamen, Fujian, China Key Laboratory of Low‐Carbon Green Agriculture, Ministry of Agriculture and Rural Affairs, Interdisciplinary Research Center for Agriculture Green Development in Yangtze River Basin, College of Resources and Environment, and Academy of Agricultural Sciences Southwest University Chongqing China Blood and Coagulation Research Department, Combat Mortality Prevention Division, United States Army Institute of Surgical Research JBSA Fort Sam Houston San Antonio Texas USA Department of Physiology and Cell Biology College of Medicine and Davis Heart and Lung Research Institute The Ohio State University Columbus OH 43210 USA Laboratory for Advanced Materials, Department of Chemical Engineering, Tsinghua University, Beijing, 100084, P. R. China School of Chemical and Biomedical Engineering, Nanyang Technological University, 62 Nanyang Drive, Singapore 637459, Singapore. State Key Laboratory of Agricultural Microbiology, Hubei Hongshan Laboratory, Engineering Research Center of Green Development for Conventional Aquatic Biological Industry in the Yangtze River Economic Belt, Ministry of Education, College of Fisheries, Huazhong Agricultural University, Wuhan, China Key Laboratory of Synthetic and Natural Functional Molecule Ministry of Education; College of Chemistry and Materials Science; Northwest University; Xi'an 710069; P. R. China State Key Laboratory of Membrane Biology and Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Institute of Molecular Medicine and Peking-Tsinghua Center for Life Sciences, and PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing 100871, China. Beijing Advanced Innovation Center for Food Nutrition and Human Health, Key Laboratory of Functional Dairy, College of Food Science and Nutritional Engineering, China Agricultural University, 100083 Beijing, China Department of Gastrointestinal Surgery, First Hospital of Jilin University, Changchun, 130021 Jilin, China School of Electronic Science and Engineering, Nanjing University, Nanjing, China Department of Ophthalmology, Putuo Hospital, Affiliated Shanghai Traditional Medicine University, Shanghai, China Department of Preventive Dentistry, Hebei Key Laboratory of Stomatology, Hebei Clinical Research Center for Oral Diseases, School and Hospital of Stomatology Hebei Medical University Shijiazhuang China Collaborative Innovation Center for Advanced Organic Chemical Materials Co‐constructed by the Province and Ministry Ministry of Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules College of Chemistry and Chemical Engineering Hubei University Wuhan 430062 China Center of Anti-Cancer Research, Medical College of Xiamen University, Xiamen, Fujian, China. Key Laboratory of Molecular Microbiology & Technology, Ministry of Education, Tianjin Economic-Technological Development Area, Tianjin, PR China; TEDA Institute of Biological Sciences & Biotechnology, Nankai University, Tianjin Economic-Technological Development Area, Tianjin, PR China; Tianjin Key Laboratory of Microbial Functional Genomics, Tianjin Economic-Technological Development Area, Tianjin, PR China Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA. Beijing National Laboratory for Molecular Sciences, State Key Laboratory of Rare Earth Materials Chemistry and Applications, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, People's Republic of China College of Food Science and Engineering, Ocean University of China Qingdao Shandong Province China Department of Pulmonary and Infectious Diseases and BREATH German Center for Lung Research (DZL), Hannover Medical School , Hannover , Germany Department of Pharmacy, Children’s Hospital of Chongqing Medical University, Chongqing, China; National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing Key Laboratory of Pediatrics, Chongqing, China Ministry of Education Key Laboratory of Metabolism and Molecular Medicine, Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai, China; Hubei Key Laboratory for Kidney Disease Pathogenesis and Intervention, Huangshi Central Hospital of Edong Healthcare Group, Hubei Polytechnic University School of Medicine, Huangshi, Hubei, China School of Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100102, China State Key Laboratory for Superlattices and Microstructures Institution of Semiconductors, Chinese Academy of Science Beijing 100083 PR China; Wuhan National Laboratory for Optoelectronics (WNLO) and School of Optical and Electronic Information Huazhong University of Science and Technology (HUST) Wuhan 430074 PR China School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, P. R. China School/Hospital of Stomatology Lanzhou University Lanzhou China Department of Molecular Medicine, College of Biology, State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan University, Changsha, China School of Computer Science and Technology, Harbin Institute of Technology Shenzhen Graduate School, China Guangzhou Institute of Cardiovascular Disease, the Second Affiliated Hospital of Guangzhou Medical University , Guangzhou 510260 , China Xianyang Key Laboratory of Molecular Imaging and Drug Synthesis, School of Pharmacy, Shaanxi Institute of International Trade & Commerce, Xianyang 712046, Shaanxi, China Guangzhou University of Chinese Medicine, Guangzhou, China Materials Science and Technology Division; Oak Ridge National Laboratory; Oak Ridge, USA Hubei Key Laboratory for Kidney Disease Pathogenesis and Intervention, Hubei Polytechnic University School of Medicine, Huangshi, Hubei, People's Republic of China From the *Department of Nuclear Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China; and †Department of Radiology, Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA. Key Laboratory of Superlight Materials and Surface Technology Ministry of Education College of Material Sciences and Chemical Engineering Harbin Engineering University Harbin 150001 China Univ. Bordeaux, CNRS, CRPP, UMR 5031, F-33600 Pessac, France; Univ. Bordeaux, CNRS, Bordeaux INP, ICMCB, UMR 5026, F-33600 Pessac, France Southwest Agricultural University, Chongqing Beibei, 400716, China.; Beijing Institute of Genomics of Chinese Academy of Sciences, Beijing Genomics Institute, Beijing Proteomics Institute, Beijing 101300, China.; James D. Watson Institute of Genome Sciences of Zhejiang University, Hangzhou Genomics Institute, Key Laboratory of Genomic Bioinformatics of Zhejiang Province, Hangzhou 310008, China.; University of Washington Genome Center, Department of Medicine, University of Washington, Seattle, WA 98195, USA. Department of Radiology, The First Affiliated Hospital of Anhui Medical University, Hefei, China Institute of Applied Microbiology, College of Agriculture, Guangxi University, Nanning, PR China Department of Physiology and Cell Biology, The Ohio State University, Columbus, OH 1; Davis Heart and Lung Research Institute, Columbus, OH 3 Department of Reproductive Medicine The First Affiliated Hospital of Harbin Medical University Harbin China Department of Obstetrics and Gynecology The First Affiliated Hospital of Sun Yat‐sen University Guangzhou China Department of Genetics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030; Institute for Personalized Respiratory Medicine, College of Medicine, University of Illinois at Chicago, Chicago, Illinois State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China School of Computer Science and Technology, Beijing Institute of Technology, Beijing, China; Advanced Research Institute of Multidisciplinary Science, Beijing Institute of Technology, Beijing, China Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Institute of Military Veterinary Medicine, Academy of Military Medical Sciences, Changchun, 130122, P. R. China Center of Super‐Diamond and Advanced Films (COSDAF) Department of Materials Science and Engineering City University of Hong Kong Tat Chee Avenue Kowloon Hong Kong China State Key Laboratory of Biomembrane and Membrane Biotechnology and Beijing Key Laboratory of Cardiometabolic Molecular Medicine; Institute of Molecular Medicine and PKU-IDG/McGovern Institute for Brain Research and Peking-Tsinghua Center for Life Sciences; Peking University; Beijing 100871, China National Demonstrative School of Software, Dalian University of Technology, Dalian 116620, Liaoning, China State Key Laboratory of Elemento‐Organic Chemistry Institute of Elemento‐Organic Chemistry, Nankai University Tianjin 300071 People's Republic of China Thoracic Oncology Department Sichuan Cancer Hospital Sichuan China Department of Neurology, Ann Romney Center for Neurologic Diseases, Brigham and Women’s Hospital, Boston, MA 02115, USA; Departments of Neurology, Harvard Medical School, Boston, MA 02115, USA Department of Dermatology, Xijing Hospital The Fourth Military Medical University Xi'an Shaanxi Province China College of Chemistry and Chemical Engineering; Hunan Provincial Key Laboratory of Chemical Power Sources; Hunan Provincial Key Laboratory of Efficient and Clean Utilization of Manganese Resources; Central South University; Changsha Chongqing University Central Hospital School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, China Key Laboratory of Agricultural Environmental Microbiology, Ministry of Agriculture, College of Life Sciences, Nanjing Agricultural University, Nanjing, Jiangsu 210095, PR China Department of Nuclear Medicine, West China Hospital Sichuan University Chengdu China Department of Radiology, Zhong-Da Hospital of Southeast University, Nanjing, P. R. China Department of PharmacodynamicsCollege of Pharmacy, University of FloridaGainesvilleFloridaUSA School of Chemical and Biomedical Engineering, Nanyang Technological University, 62 Nanyang Drive, Singapore 637459, Singapore Key Laboratory for Special Functional Materials of Ministry of Education Collaborative Innovation Center of Nano Functional Materials and Applications School of Materials Science and Engineering Henan University Kaifeng 475004 P. R. China Department of Physics and Astronomy, The University of Iowa , Iowa City, Iowa 52242, USA Department of Neurosurgery Peking University Third Hospital Beijing People's Republic of China Department of Gastrocolorectal Surgery The First Hospital of Jilin University Changchun PR China Department of Endodontics Ninth People's Hospital Shanghai Jiaotong University, School of Medicine Shanghai Key Laboratory of Stomatology China Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore 117585; Institute of Materials Research and Engineering, A*STAR (Agency for Science, Technology and Research), 3 Research Link, Singapore 117602 Institute of Crop Science Chinese Academy of Agricultural Sciences Beijing 100081 China Department of General Surgery, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200011, P.R. China Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun 130022, China Department of Basic Western Medicine, Jiamusi College of Heilongjiang University of Chinese Medicine, Heilongjiang, China Department of Nephrology, The Affiliated Wuxi People’s Hospital of Nanjing Medical University, Wuxi, China Department of Emergency Trauma Surgery, First People’s Hospital of Yunnan Province (the Affiliated Hospital of Kunming University of Science and Technology), Kunming, Yunnan 650032, China College of Materials Science and Engineering; Huaqiao University; Key Laboratory of Molecular Designing and Green Conversions (Fujian University); Xiamen 361021; China CAS Key Laboratory of Colloid, Interface and Chemical Thermodynamics, CAS Research/Education Center for Excellence in Molecular Sciences, Beijing National Laboratory for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China; University of Chinese Academy of Sciences, Beijing 100049, P. R. China Institute of Applied Microbiology, College of Agriculture, Guangxi University Nanning 530005 China; Guangxi Key Laboratory for Agro‐Environment and Agro‐Product Safety Nanning Department of Cardiology, the Second Hospital of Jilin University, Changchun, China School of Energy and Power Engineering North University of China Taiyuan 03005 China School of Public Health Zhejiang Chinese Medical University Hangzhou China School of Applied Science, Taiyuan University of Science and Technology, Taiyuan, China Pen-Tung Sah Institute of Micro-Nano Science and Technology of Xiamen University; Xiamen, China Fujian Provincial Engineering Technology Research Center of Photoelectric Sensing Application Nephrology Department, Wuxi People‘s Hospital Affiliated to Nanjing Medical University , Wuxi , China Institute for Innovative Development of Food Industry Shenzhen University Shenzhen 518060 China; Shenzhen Key Laboratory of Marine Microbiome Engineering Institute for Advanced Study Shenzhen University Shenzhen 518060 China School of Chemical & Biomedical Engineering Nanyang Technological University Singapore 637459 Singapore Department of Spine SurgeryThe Third Affiliated HospitalSun Yat-Sen UniversityGuangzhouChina Department of Chemical Engineering and Materials Science, University of Minnesota, 421 Washington Avenue SE, Minneapolis, Minnesota 55455, United States Department of Chemistry, University of California, Berkeley, California 94720, United States; School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore 637459, Singapore Department of Chemistry, University of Massachusetts, Amherst, Massachusetts 01003, United States; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139, United States CovX Research, Biotherapeutics Division of Pfizer, San Diego, CA 92121; and Postgraduate Student, Key Laboratory of Machine Perception, Peking University, Haidian District, Beijing, China Department of Chemical and Biomolecular Engineering, 4 Engineering Drive 4, National University of Singapore, 117576 Singapore School of Nuclear Science and Technology, Lanzhou University, Lanzhou 730000, China; School of Stomatology, Lanzhou University, Lanzhou 730000, China College of Life Science and Bioengineering Beijing University of Technology Beijing 100124 China 1 School of Computer Science and Technology,; 2 Key Laboratory of Network Oriented Intelligent Computation, Harbin Institute of Technology Shenzhen Graduate School, Shenzhen, Guangdong 518055, China and; 3 Gordon Life Science Institute, Belmont, MA 02478, USA State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China; University of Chinese Academy of Sciences, Beijing 100049, China Center of Super-Diamond and Advanced Films (COSDAF); Department of Materials Science and Engineering; City University of Hong Kong; Hong Kong SAR; P. R. China Department of Chemical Engineering, Laboratory for Advanced Materials, Tsinghua University, Beijing 100084, P. R. China Department of Rheumatology and Immunology First Teaching Hospital of Tianjin University of Traditional Chinese Medicine Tianjin P.R. China State Key Laboratory of Biomembrane and Membrane Biotechnology and Beijing Key Laboratory of Cardiometabolic Molecular Medicine Institute of Molecular Medicine and Peking‐Tsinghua Center for Life Sciences and PKU‐IDG/McGovern Institute for Brain Research Peking University Beijing 100871 China Radiology, Huashan Hospital, Fudan University; Shanghai University 1 Laboratory of Metallurgy and Materials Processing, College of Materials Science and Engineering, , Shanghai 200072, People’s Republic of China Department of Periodontology Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology National Clinical Research Center of Stomatology Ninth People's Hospital Shanghai Jiao Tong University School of Medicine China Department of Chemical and Biomolecular Engineering, National University of Singapore 4 Engineering Drive 4 Singapore 117585 Singapore Department of Pharmacology, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, China; Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, China Department of Spine Surgery, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China (mainland) Department of Urology Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang City, Hebei, China Department of General Surgery, the Affiliated Hospital of Xuzhou Medical College, Xuzhou 221002, China. liubinxy@pub.xz.jsinfo.net First Division, Department of Respiratory and Critical Care Medicine, Zhuzhou Hospital, Affiliated to Xiangya School of Medicine, Central South University/Zhuzhou Central Hospital, Zhuzhou Hunan 412007, China. robin0336@126.com. First Clinical College of Medicine, Lanzhou University, 1st West Donggang R.D., Lanzhou 730000, China Venatorx Pharmaceuticals Incorporated, Malvern, Pennsylvania, USA Pharmaron Xi’an Co., Xi’an, Shaanxi 710018, China Shaanxi Key Laboratory for Advanced Energy Devices, Shaanxi Engineering Laboratory for Advanced Energy Technology, Key Laboratory of Macromolecular Science of Shaanxi Province, School of Materials Science and Engineering, Shaanxi Normal University, Xi’an, 710119, China Department of Paediatric Cardiology, West China Second Hospital, Sichuan University, Chendu 641000, China. Department of Chemical and Biomolecular Engineering National University of Singapore 4 Science Drive 4 117585 Singapore Singapore Department of Central Laboratory Department of Pharmacology, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha 410078, China. Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of the Ministry of Education, Shaanxi Key Laboratory of Physico−Inorganic Chemistry, College of Chemistry & Materials Science, Northwest University, Xi'an 710069, P. R. China School of Chemistry and Chemical Engineering Jiangsu University Xuefu Road 301 Zhenjiang 212013 China; Jurong Ningwu New Material Development Co. Ltd. Zhenjiang 212405 China 1Department of Anesthesia,; 4Comprehensive Cancer Center, University of California-San Francisco, San Francisco, California and From the Department of Ophthalmology and Visual Sciences, Illinois Eye and Ear Infirmary, Chicago, Illinois; Key Laboratory of Dental Maxillofacial Reconstruction and Biological Intelligence Manufacturing of Gansu Province, Lanzhou University, Lanzhou 730000, People’s Republic of China; School of Stomatology, Lanzhou University, Lanzhou 730000, People’s Republic of China College of Pulmonary and Critical Care Medicine, Chinese PLA General Hospital, China; Medical School of Chinese PLA, China Second Hospital of Jilin University Changchun China Department of Physiology, Medical College of Qingdao University, Qingdao 266021. Department of Medicine and Department of Hematology, Blood Desease Hospital, Chinese Academy of Medical Sciences, Tanjing 300020, China. E-mail:binliuwcums@163.com. College of Biology, Hunan University, Changsha 410082, China; NHC Key Laboratory of Metabolic Cardiovascular Diseases Research, Department of Physiology & Pathophysiology, School of Basic Medical Sciences, Ningxia Medical University, 750004 Yinchuan, PR China Department of Interventional Medicine, The Second Hospital of Shandong University, Institute of Tumor Intervention, Shandong University, Jinan City, Shandong Province, China Department of Radiology, Binhai County People’s Hospital, YanCheng 224500, China; Department of Radiology, Zhongda Hospital, Southeast University, Nanjing 210009, China Department of Chemical and Biomolecular Engineering; National University of Singapore; Singapore 117576; Institute of Materials Research Engineering; Singapore 117602 Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China Graduate School of Tianjin University of TCM, Tianjin 300193, China. liubin0523@yahoo.com.cn Department of Urology China-Japan Union Hospital of Jilin University Changchun 130033 China Department of Haematology Changhai Hospital of the Second Military Medical University Shanghai China; Department of Respiratory Medicine The People's Liberation Army General Hospital Shanghai China Key Laboratory of Superlight Materials and Surface Technology; Ministry of Education; College of Materials Science and Chemical Engineering; Harbin Engineering University; Harbin Tianjin Key Laboratory of Refrigeration Technology, Tianjin University of Commerce, Tianjin 300134, China; International Centre in Fundamental and Engineering Thermophysics, Tianjin University of Commerce, Tianjin 300134, China; Key Lab of Agricultural Products Low Carbon Cold Chain of Ministry of Agriculture and Rural Affairs, Tianjin University of Commerce, Tianjin 300134, China College of Life Science, Fujian Agriculture and Forestry University, Fuzhou 350002, Fujian, China; Beijing Key Laboratory of Growth and Developmental Regulation for Protected Vegetable Crops College of Horticulture China Agricultural University Beijing China International School of Information Science and Engineering (DUT‐RUISE) Dalian University of Technology Dalian China Center for Molecular Biology of Heidelberg University (ZMBH) DKFZ‐ZMBH Alliance Heidelberg Germany Key Laboratory of Feed Biotechnology, Ministry of Agriculture, Beijing 100081, People’s Republic of China; Gene Engineering Laboratory, Feed Research Institute, Chinese Academy of Agricultural Sciences, Beijing 100081, People’s Republic of China Department of Oncology The Second Xiangya Hospital Central South University Changsha Hunan China Department of Anesthaesiology, West China Hospital Sichuan University Chengdu Sichuan China; National‐Local Joint Engineering Research Center of Translational Medicine of Anesthaesiology, West China Hospital Sichuan University Chengdu Sichuan China Department of Cardiology The Second Affiliated Hospital of Chongqing Medical University No. 74, Linjiang Road, Yuzhong District Chongqing 400010 China Department of Oncology, The Second Hospital of Xiangya, Central South University, Changsha, Hunan 410011, P.R. China School of Chemical Engineering, Inner Mongolia Key Laboratory of Theoretical and Computational Chemistry Simulation, Inner Mongolia University of Technology, Hohhot 010051, People’s Republic of China State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 P. R. China; Key Laboratory of Superlight Materials and Surface Technology Ministry of Education College of Material Sciences and Chemical Engineering Harbin Engineering University Harbin 150001 P. R. China Northwest A&F University College of Food Science and Engineering Yangling Shaanxi China; Laboratory of Quality & Safety Risk Assessment for Agro‐products (Yangling) Ministry of Agriculture Yangling Shaanxi China; National Engineering Research Center of Agriculture Integration Test (Yangling) Yangling Shaanxi China Institute of Applied Microbiology, Guangxi University, Nanning 530005, PR China Department of Biomedical Engineering, School of Basic Medical Sciences Nanjing Medical University Nanjing China Department of Pharmacodynamics, University of Florida, 1345 Center Drive, Box 100487, Gainesville, FL, 32610, USA. liu@cop.ufl.edu. Cardiovascular Research Center Shantou University Medical College Shantou China Shanghai Universities E-Institute for Chemical Biology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine (SJTU-SM), Shanghai 200025, China Department of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China. From the State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China; Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guizhou University, Huaxi District, Guiyang 550025, China; Division of Chemistry & Biological Chemistry, School of Physical & Mathematical Sciences, Nanyang Technological University, Singapore 637371, Singapore Departments of Chemistry and Biochemistry and Materials, Institute for Polymers and Organic Solids, University of California, Santa Barbara, California 93106 Department of Environmental Health, School of Public Health, Zhengzhou University , Zhengzhou, Henan 450001 , P. R. China Tianjin University of TCM, Tianjin 300193, China. liubin0523@yahoo.com.cn Centre for Systems Chemistry Stratingh Institute University of Groningen Nijenborgh 4 9747 AG Groningen Netherlands Department of Neurology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China; Department of Neurology, Minhang Hospital, Fudan University, Shanghai, China State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Qianjin Street, Changchun 130012, P.R. China Department of Nephrology and Rheumatology, Chinese Medicine Hospital of Hainan Province, Haikou, China Micro‐ and Nano‐manufacturing Research Center State Key Laboratory for Manufacturing Systems Engineering Xi'an Jiaotong University 28 Xianning Road Xi'an 710049 P. R. China Centre for Medical Device Evolution Beijing China Department of Neurology, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, China Department of Chemical and Biomolecular Engineering; National University of Singapore; Singapore 117585; Institute of Materials Research and Engineering (A*STAR); Singapore 117602 International School of Information Science and Engineering (DUT-RUISE), Dalian University of Technology, Dalian, Liaoning 116620, China; DUT-RU Co-Research Center of Advanced ICT for Active Life, Dalian University of Technology, Dalian, Liaoning 116620, China; Key Lab of Ubiquitous Network and Service Software of Liaoning Province, Dalian University of Technology, Dalian, Liaoning 116620, China Department of Orthopedics, Guangdong General Hospital/Guangdong Academy of Medical Sciences, Guangzhou 510080, China. Department of Urology, Shanghai Changhai Hospital, Second Military Medical University, Shanghai, China 1Anesthesia and Departments of; 3University of California San Francisco Comprehensive Cancer Center, San Francisco, California; Department of Nuclear Medicine; West China Hospital; Sichuan University; Chengdu China College of Material Science and Engineering Huaqiao University Xiamen 361021 People's Republic of China The University of Iowa Department of Physics and Astronomy, , Iowa City, Iowa 52242 Department of Chemistry, Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Tsinghua University, Beijing 100084, China Department of Physiology and Cell Biology, Davis Heart and Lung Research Institute, Ohio State University, Columbus, OH; Department of Biological Sciences, Mississippi State University, Starkville, MI Department of Health Sciences, University of York, York, United Kingdom. State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 China; University of the Chinese Academy of Sciences Beijing 100049 China School of Stomatology of Lanzhou University Lanzhou 730000 People's Republic of China Department of Chemical and Biomolecular Engineering National University of Singapore, 4 Engineering Drive Singapore 117576 School of Chemistry and Chemical Engineering Liaocheng University Liaocheng 252059 P. R. China Computer Technology Center, Beijing 302 Hospital, Beijing, China; Key Laboratory of Freshwater Fish Reproduction and Development, Ministry of Education, Chongqing 400715, China. Department of Cardiology, The Fourth People's Hospital of Jinan Jinan 250031, Shandong, China. Department of Chemistry; University of Akron; Akron; USA Fengtai District Community Health Service Center. Beijing 100071,China. School of Computer Science and Technology, Harbin Institute of Technology Shenzhen Graduate School, Shenzhen, Guangdong 518055, China; Key Laboratory of Network Oriented Intelligent Computation, Harbin Institute of Technology Shenzhen Graduate School, Shenzhen, Guangdong 518055, China MOE Key Laboratory of Bioinorganic and Synthetic Chemistry School of Chemistry State Key Laboratory of Oncology in South China Sun Yat-Sen University Guangzhou 510275 P. R. China School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong, China Key Laboratory of Bioinorganic and Synthetic Chemistry of Ministry of Education School of Chemistry IGCME Sun Yat-Sen University Guangzhou 510275 China College of Food Science Fujian Agriculture and Forestry University Fuzhou China Department of Medical Oncology, Sichuan Cancer Hospital, Chengdu 610041, China Center of Super-Diamond and Advanced Films (COSDAF) & Department of Materials Science and Engineering, City University of Hong Kong, Tat Chee Avenue, Kowloon 999077, Hong Kong, China State Key Laboratory of Plant Genomics and National Center for Plant Gene Research, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China; Graduate University of the Chinese Academy of Sciences, Beijing 100039, China School of Stomatology; Lanzhou University; Lanzhou; China Department of Chemical and Biomolecular Engineering National University of Singapore Singapore 117585 Guangdong Provincial Key Laboratory of Sensor Technology and Biomedical Instrument School of Biomedical Engineering Shenzhen Campus of Sun Yat‐Sen University Shenzhen 518107 P. R. China Department of Materials Science and Engineering, Shenzhen Key Laboratory of Full Spectral Solar Electricity Generation (FSSEG), Southern University of Science and Technology, No. 1088, Xueyuan Rd., Shenzhen 518055, Guangdong, China Zhong-Da Hospital, Southeast University, Nanjing, China School of Nuclear Science and Technology, Lanzhou University, Lanzhou, Gansu, China; School of Stomatology, Lanzhou University, Lanzhou, Gansu, China Department of Anesthesia, UCSF Helen Diller Family Comprehensive Cancer Center, University of California at San Francisco, 1001 Potrero Avenue, 1305, San Francisco, CA, 94110, USA. bin.liu@ucsf.edu. National Laboratory of Solid State Microstructures and Collaborative Innovation Center of Solid‐State Lighting and Energy‐Saving Electronics School of Electronic Science and Engineering Nanjing University Nanjing 210093 China Department of Anesthesiology and Translational Neuroscience Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China TEDA School of Biological Sciences and Biotechnology Shanxi University School of Computer Science and Technology, Harbin Institute of Technology Shenzhen Graduate School, Shenzhen, Guangdong, China; The Gordon Life Science Institute, Boston, MA, USA The Second Hospital of Jilin University Nanguan Changchun China The People's Hospital of Lishni, Lishui 323000, Zhejiang, China. Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, the Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China Department of Spine Surgery, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou,China Department of Gastrointestinal Surgery The Second Hospital of Tianjin Medical University Tianjin China Institute for Personalized Respiratory Medicine, Section of Pulmonary and Critical Care, Sleep and Allergy, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois; Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education College of Chemistry & Materials Science Northwest University Xi'an 710127 China Entomology and Nematology Department Citrus Research and Education Center University of Florida Florida USA; Key Laboratory of Entomology and Pest Control Engineering College of Plant Protection Southwest University Chongqing China Fujian Medical University, School of Basic Medical Sciences, Laboratory of Pain Research, Key Laboratory of Brain Aging and Neurodegenerative Diseases, Neuroscience Research Center, Fuzhou City, Fujian Province, People's Republic of China School of Chemical and Biomedical Engineering Nanyang Technological University Singapore 637459 Singapore; Division of Chemistry and Biological Chemistry School of Physical and Mathematical Sciences Nanyang Technological University 21 Nanyang Link Singapore 637371 Singapore Key Laboratory of Superlight Materials and Surface Technology Ministry of Education College of Material Sciences and Chemical Engineering Harbin Engineering University Harbin 150001 P. R. China Department of Cardiology, Jilin University the Second Hospital, Changchun, China. Department of Traditional Chinese Medicine Orthopedics, Affiliated Hospital of Shandong Academy of Medical Sciences Department of Urology Surgery, the Fourth Hospital of Hebei Medical University, Shijiazhuang, China. Institute of Nano Biomedicine and Engineering, Shanghai Engineering Research Center for Intelligent Diagnosis and Treatment Instrument, Department of Instrument Science and Engineering, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, China. National Center for Translational Medicine, Collaborative Innovational Center for System Biology, Shanghai Jiao Tong University, China. Division of Pulmonary, Critical Care and Sleep (D.Y., B.L., S.L., R.L., J.P., K.R., X.X., K.S.K., Z.D.), University of Arizona, Phoenix.; Department of Internal Medicine (D.Y., B.L., S.L., R.L., J.P., K.R., X.X., M.K., T.W., K.S.K., C.C.G., M.B.F., Z.D.), University of Arizona, Phoenix.; Translational Cardiovascular Research Center (D.Y., B.L., W.H.L., C.C.G., Z.D.), University of Arizona, Phoenix. Key Laboratory of Superlight Materials and Surface Technology, College of Materials Science and Chemical Engineering, Ministry of Education, Harbin Engineering University, Harbin 150001, P.R. China Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, 294 Taiyuan Road, Shanghai 200031, China Department of Anesthesiology, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, P.R. China Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences/National Institutes of Health, Research Triangle Park, North Carolina, USA. liu3@niehs.nih.gov Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai, China Department of Cancer Epidemiology National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China Vegetable Technical Extension Station Qingpu District Shanghai Shanghai China Department of Urologic Sciences, University of British ColumbiaVancouver, BC, Canada; Department of Critical Care Medicine, General Hospital of Tianjin Medical UniversityTianjin, China. School of Computer Science and Technology, Harbin Institute of Technology Shenzhen Graduate School, Shenzhen 518055, China 4Roche Pharma Research and Early Development, Roche Innovation Center Shanghai, Shanghai, China. Biomedical Engineering Center, State Key Lab of Chemo/Biosensing & Chemometrics, College of Chemistry & Chemical Engineering, College of Materials Science & Engineering, Hunan University. Engineering Reasearch Center for Bio-Nanotechnology of Hunan Province, Changsha 410082, China Coagulation and Blood Research Program United States Army Institute of Surgical Research Fort Sam Houston TX USA College of Bioengineering, Henan University of Technology, Zhengzhou, China Department of Chemical and Biomolecular Engineering, National University of Singapore, Singapore Key Laboratory of Superlight Materials and Surface Technology Ministry of Education College of Material Sciences and Chemical Engineering Harbin Engineering University Harbin 150001 P. R. China; State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 P. R. China; Key Laboratory of In‐Fiber Integrated Optics of Ministry of Education College of Physics and Optoelectronic Engineering Harbin Engineering University Harbin 150001 P. R. China Qingdao Mental Health Center, Qingdao University, Shandong, China Key Laboratory of Advanced Ceramics and Machining Technology (Ministry of Education) School of Materials Science and Engineering Tianjin University Tianjin 300072 China Jiamusi College, Heilongjiang University of Chinese Medicine, Jiamusi, Heilongjiang, China (mainland) Department of Chemical and Biomolecular Engineering; National University of Singapore 4 Engineering Drive 4117585 Singapore (Republic of Singapore) and Institution of Materials Research and Engineering A*STAR3 Research Link; 117602 Singapore Republic of Singapore National and Local Joint Engineering Laboratory for Optical Conversion Materials and Technology of National Development and Reform Commission School of Materials and Energy Lanzhou University Lanzhou 730000 China Institute for Metabolic and Neuropsychiatric Disorders, Binzhou Medical University Hospital, Binzhou, Shandong 256603, P.R. China Department of General Surgery, Shanghai Tenth People’s Hospital of Tongji University, Tongji University, Shanghai , China; Department of General Surgery, Shanghai Clinical Medical College, Anhui Medical University, Anhui , China Department of Chemistry, Zhejiang University, Hangzhou 310027, China Centre for Systems Chemistry, Stratingh Institute, University of Groningen, Nijenborgh 4, 9747 AG Groningen, The Netherlands Department of Chemical and Biomolecular Engineering; National University of Singapore; Singapore; Institute of Materials Research and Engineering; Singapore Department of Electrical Engineering and Computer Science, University of Michigan, Ann Arbor, Michigan 48109, United States Department of Interventional Medicine, The Second Hospital of Shandong University, Jinan, People's Republic of China. Nuclear Medicine Beijing Institute of Aerospace Systems Engineering, Beijing 100076, China Department of Thyroid and Breast Surgery, Tengzhou Central People's Hospital, Tengzhou, Shandong, China (mainland) Henan Key Laboratory for Helicobacter pylori & Microbiota and GI Cancer Marshall Medical Research Center The Fifth Affiliated Hospital of Zhengzhou University Zhengzhou China; Department of Gastroenterology The Fifth Affiliated Hospital of Zhengzhou University Zhengzhou China Key Laboratory of Molecular Microbiology and Technology Ministry of Education Tianjin China; TEDA Institute of Biological Sciences and Biotechnology Nankai University Tianjin China; Tianjin Key Laboratory of Microbial Functional Genomics Nankai University Tianjin China Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore 117585; Institute of Materials Research and Engineering, 3 Research Link, Singapore 117602 Department of Chemistry, Princeton University, Princeton, New Jersey 08544 Etaylor@princeton.edu Department of Chemical and Biomolecular Engineering; National University of Singapore; , Singapore; Institute of Materials Research and Engineering; , Singapore Department of Rheumatology and Immunology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China. Center of Systematic Genomics, Xinjiang Institute of Ecology and Geography, Urumqi, China; Beijing Institute of Genomics, Beijing, China; Chinese Academy of Sciences, Beijing, China Department of Anaesthesiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China. Key Laboratory of Data Engineering and Visual Computing, Chongqing University of Posts and Telecommunications , Chongqing 400065 , China Department of Public Health Sciences (E.L.P., B.L.), Department of Internal Medicine, Henry Ford Hospital, Detroit, MI. College of Pharmacy Liaoning University Shenyang People's Republic of China; Key Laboratory of New Drug Research and Development of Liaoning Province Shenyang People's Republic of China School of Chemical Engineering, Northeast Electric Power University, Jilin 132012, China Key Laboratory of Clinical and Medical Engineering, Department of Biomedical Engineering, School of Biomedical Engineering and Informatics, Nanjing Medical University, Nanjing 211166, China Key Laboratory of Theoretical Chemistry and Molecular Simulation of Ministry of Education, Hunan Province College Key Laboratory of QSAR/QSPR, School of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan, Hunan 411201, China Department of Orthopedics The Second Hospital, Jilin University Changchun China Department of Orthopedics, First Affiliated Hospital of Harbin Medical University, Harbin, P.R. China. School of Chemical and Biomedical Engineering; Nanyang Technological University; 62 Nanyang Drive Singapore 637459 Singapore Key Laboratory for Organic Electronics and Information Displays & Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing University of Posts & Telecommunications, 9 Wenyuan Road, Nanjing, China Guangdong Key Laboratory of Environmental Pollution and Health, School of Environment Jinan University Guangzhou 511443 P.R. China School of Basic Medical Sciences, Hubei University of Medicine, Shiyan, China; Hubei Key Laboratory of Embryonic Stem Cell Research, Taihe Hospital of Shiyan, Hubei University of Medicine, Shiyan, China School of Computer Science and Technology, Harbin Institute of Technology Shenzhen Graduate School, Shenzhen, Guangdong 518055, China; Key Laboratory of Network Oriented Intelligent Computation, Harbin Institute of Technology Shenzhen Graduate School, Shenzhen, Guangdong 518055, China; Shanghai Key Laboratory of Intelligent Information Processing, Shanghai 518055, China; Gordon Life Science Institute, Belmont, Massachusetts, USA School of Engineering, Box D, Brown University, Providence, RI 02912; and Department of Cardiology the Second Hospital of Jilin University Changchun 130041 P. R. China Guangdong Key Laboratory of New Technology in Rice Breeding Rice Research Institute Guangdong Academy of Agricultural Sciences Guangzhou China Department of Rheumatology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266003, P.R. China School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, China; The Key Research Laboratory of "Exploring Effective Substance in Classic and Famous Prescriptions of Traditional Chinese Medicine". The State Administration of Traditional Chinese Medicine of the People’s Republic of China, Beijing, China Henan Key Laboratory of Polyoxometalate Chemistry, Institute of Molecular and Crystal Engineering, College of Chemistry and Chemical Engineering, Henan University, Kaifeng, Henan 475004, P. R. China School of Chemical & Biomedical Engineering, Nanyang Technological University, 62 Nanyang Drive, Singapore 637459, Singapore Key Laboratory of Superlight Materials and Surface Technology, Ministry of Education, College of Material Sciences and Chemical Engineering, Harbin Engineering University, Harbin 150001, P. R. China Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, 117576, Singapore National Engineering Research Center of Juncao, Fuzhou, Fujian 350002, China. liubin618@hotmail.com The Key Laboratory of Metabolism and Molecular Medicine of the Ministry of Education Department of Endocrinology and Metabolism Fudan Institute for Metabolic Diseases Zhongshan Hospital Fudan University Shanghai 230032 P. R. China Epigenetic and Molecular Carcinogenesis Department of Interventional Medicine, The Second Hospital, Cheeloo College of Medicine Shandong University Jinan City China Department of Gynecology, Fujian Cancer Hospital, Clinical Oncology School of Fujian Medical University, Fuzhou, China Department of Obstetrics and Gynecology, The First Affiliated Hospital, Sun Yat-sen University, No. 58th Zhongshan 2nd Road, Guangzhou 510080, China Department of Physics, The Chinese University of Hong Kong, Shatin, Hong Kong, P. R. China Guizhou University, Ministry of Education, State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Guiyang 550025, China School of Chemical Engineering and Technology; Key Laboratory for Green Chemical Technology of Ministry of Education, Tianjin University, Tianjin 300072, China; Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin 300072, China; Haihe Laboratory of Sustainable Chemical Transformations, Tianjin 300192, China Guangdong Provincial Key Laboratory of Sensor Technology and Biomedical Instrument, School of Biomedical Engineering, Sun Yat-Sen University, Guangzhou, PR China; Department of Chemical and Biomolecular Engineering (ChBE) National University of Singapore (NUS) Singapore Department of Neurology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China C. D. Chung and J. Liao, Department of Biological Chemistry, University of California, Los Angeles, CA 90095, USA.; B. Liu and X. Rao, Division of Hematology-Oncology, Department of Medicine, University of California, Los Angeles, CA 90095, USA.; P. Jay and P. Berta, Centre de Recherche de Biochimie Macromoleculaire, 1919 route de Mende, 34000 Montpellier, France.; K. Shuai, Division of Hematology-Oncology, Department of Medicine; Department of Biological Chemistry; and Molecular Biology Institute, University of California, 11-934 Factor Building, 10833 LeConte Avenue, Los Angeles, CA 90095–1678, USA. School of Computer Science and Technology, Harbin Institute of Technology, Shenzhen, Guangdong, China; School of Computer Science and Technology, Beijing Institute of Technology, Beijing, China Department of Chemical and Biomolecular Engineering National University of Singapore 117576 Singapore; Institute of Materials Research and Engineering 2 Fusionopolis Way Innovis 138634 Singapore School of Medicine, Shandong University, Jinan, Shandong 250012, P.R. China National Chengdu Center for Safety Evaluation of Drugs; National Key Laboratory of Biotherapy, West China Hospital of Sichuan University State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Kunming, Yunnan 650201, China Department of Chemical and Biomolecular Engineering; National University of Singapore; Singapore 117585 Department of Neurology, Shanghai Minhang Hospital, Fudan University, Shanghai, China; Department of Neurology, Shanghai Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China School of Reliability and Systems Engineering, Beihang University, Beijing 100191, China; Science & Technology on Reliability & Environmental Engineering Laboratory, Beijing 100191, China Department of Materials Science and Engineering Southern University of Science and Technology (SUSTech) No. 1088, Xueyuan Road Shenzhen Guangdong 518055 P. R. China Hunan Province Key Laboratory of Plant Functional Genomics and Developmental Regulation, College of Biology, Hunan University, Changsha, China National Engineering Center of Dairy Health for Maternal and Child, Beijing Sanyuan Foods Co. Ltd, Beijing, China International School of Information Science and Engineering, Dalian University of Technology, China Guangdong Key Laboratory of New Technology in Rice Breeding, Rice Research Institute Guangdong Academy of Agricultural Sciences Guangzhou China Key Laboratory of Superlight Materials and Surface Technology Ministry of Education College of Material Science and Chemical Engineering Harbin Engineering University Harbin 150001 P. R. China Department of Chemistry, Princeton University, Princeton, New Jersey 08544 Energy and Environment Directorate Pacific Northwest National Laboratory Richland WA 99354 USA Solstice Biologics 9535 Waples Street San Diego CA 92121 USA School of Computer Science and Technology; Harbin Institute of Technology Shenzhen Graduate School; HIT Campus Shenzhen University Town; Shenzhen; China Department of Microbiology, Faculty of Naval Medicine Naval Medical University Shanghai China Department of Physics/Pen-Tung Sah Institute of Micro-Nano Science and Technology, Xiamen University, Xiamen 361005, China Department of Pathology, Chinese People’s Liberation Army Joint Logistics Support Unit 940 Hospital, Lanzhou, Gansu, China Departments of Genetics, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA School of Chemistry and Chemical Engineering; Anhui University of Technology; Maanshan 243002, China Key Laboratory of Superlight Materials and Surface Technology Ministry of Education College of Materials Science and Chemical Engineering Harbin Engineering University 150001 Harbin P. R. China Department of Angiocardiology, the Second Hospital of Jilin University Department of Neurosurgery, Second Affiliated Hospital, and Department of Interventional Medicine, the Second Hospital of Shandong University, Interventional Oncology Institute of Shandong University, Jinan 250033, China. School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore Laboratory of Hepatobiliary Surgery Affiliated Hospital of Guangdong Medical University, Zhanjiang Key Laboratory of Hepatobiliary Diseases Zhanjiang People's Republic of China Department of Burn, Plastic, and Cosmetic Surgery, Xi’an Central Hospital, Xi’an Jiaotong University, Xi’an, China Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry, University of Science and Technology of China, Hefei, 230026, China Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China Department of Epigenetics and Molecular Carcinogenesis, Science Park, The University of Texas MD Anderson Cancer Center, Smithville, TX, USA Department of Pulmonary & Critical Care Medicine, Chinese People’s Liberation Army (PLA) General Hospital, Beijing, China Shenzhen Key Laboratory of Marine Microbiome Engineering, Institute for Advanced Study, Shenzhen University, Shenzhen 518060, China; Institute for Carbon Neutrality, Shenzhen University, Shenzhen 518060, China; Institute for Innovative Development of Food Industry, Shenzhen University, Shenzhen 518060, China Department of Obstetrics and Gynecology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, PR China Department of Electrical Engineering and Computer Science University of Michigan Ann Arbor MI 48109 USA School of Materials Science and Engineering, North University of China, Taiyuan 030051, People’s Republic of China Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China Department of Pathology, Basic Medical School, Chongqing Medical University, Chongqing 400016, China. *Corresponding author, E-mail: my0216@126.com. Beijing Institute of Spacecraft System Engineering, Beijing 100094, China College of Biology Hunan University Changsha China The Second Hospital of Jilin University, Changchun, China. Department of Occupational and Environmental Health, College of Public Health, Zhengzhou University, Zhengzhou, China; State Key Lab of Solidification Processing, Northwestern Polytechnical University, Xi'an 710072, China. liubins37@126.com State Key Laboratory of Pharmaceutical Biotechnology, Department of Sports Medicine and Adult Reconstructive Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China Department of Thoracic and Cardiovascular Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, China Inner Mongolia Agricultural University Hohhot China Department of Medical Oncology, Liaoning Cancer Hospital and Institute Shenyang 110042, Liaoning, China. Department of Animal Science and Medicine, College of Coastal Agricultural Sciences, Guangdong Ocean University, Zhanjiang, China Department of Chemical and Biomolecular Engineering National University of Singapore 4 Engineering Drive 4 117585 Singapore; Institute of Materials Research and Engineering (IMRE) Agency for Science Technology and Research (A*STAR) 2 Fusionopolis Way Innovis 136834 Singapore Department of Oral Biology, Stomatological College, Fourth Military Medical University. Department of Anesthesiology, West China Hospital, Sichuan University, Wuhou District, Chengdu, Sichuan Province, China. Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry & University of Chinese Academy of Sciences, the Chinese Academy of Sciences, Beijing,100190, P. R. China School of Stomatology Lanzhou University Lanzhou China; Gansu Province Key Lab of Maxillofacial Reconstruction and Intelligent Manufacturing Lanzhou China State Key Laboratory of Supramolecular Structure and Materials; College of Chemistry; Jilin University; Changchun; China Department of Urology Children's Hospital of Chongqing Medical University Chongqing China; Ministry of Education Key Laboratory of Child Development and Disorders Chongqing China Department of Hand Surgery, The First Hospital of Jilin University, Changchun, China Department of Otorhinolaryngology, the First Affiliated Hospital of China Medical University, Shenyang. liubincmu@163.com Beijing University of Chemical Technology, Beijing 100029, China School of Mathematics and Physics, Nanyang Institute of Technology, Nanyang 473004, China Tianjin Key Laboratory of Structure and Performance for Functional Molecules, MOE Key Laboratory of Inorganic−Organic Hybrid Functional Material Chemistry, College of Chemistry, Tianjin Normal University, Tianjin 300387, China Department of Chemical and Biomolecular Engineering; National University of Singapore; Singapore 117585; Singapore; Institute of Materials Research and Engineering (IMRE) Department of Spine Surgery, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510630, P.R. China Department of Cardiology, Second Hospital of Jilin University, Changchun, Jilin, P. R. China Department of Neurology; Affiliated Hospital of Hebei United University; Tangshan Hebei 063000 China Department of Environmental Health, School of Public Health, Zhengzhou University, Zhengzhou 450001, China State Key Laboratory of Chemical Resource Engineering, College of Life Science and Technology, Beijing University of Chemical Technology, Post Office Box 53, Beijing 100029, People’s Republic of China State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center Sun Yat‐Sen University Guangzhou China College of Life Sciences, Shandong Agricultural University, Taian, Shandong 271018, China. MOST–USDA Joint Research Center for Food Safety, School of Agriculture and Biology, and State Key Laboratory of Microbial Metabolism, Shanghai Jiao Tong University, Shanghai, China. Department of Epidemiology Johns Hopkins University Bloomberg School of Public Health Baltimore MD Lanzhou Petro of PetroChina Company Limited, Lanzhou 730060, China School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, China Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, P. R. China TEDA School of Biological Sciences and Biotechnology, Nankai University, 23 Hongda Street, TEDA, 300457 Tianjin, PR China Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China Authors' Affiliations: 1Center for Molecular and Functional Imaging, Department of Radiology and Biomedical Imaging; 2Department of Anesthesia; 3Helen Diller Family Comprehensive Cancer Center; and 4Department of Medicine, University of California, San Francisco, California; Authors' Affiliations: 1Center for Molecular and Functional Imaging, Department of Radiology and Biomedical Imaging; 2Department of Anesthesia; 3Helen Diller Family Comprehensive Cancer Center; and 4Department of Medicine, University of California, San Francisco, California Department of Neurosurgery, Zaozhuang Hospital of Zaozhuang Mining Group, Zaozhuang, Shandong, China China Sunsine Chemical Holdings Ltd., Shanxian City, Shandong 274300, China Department of Radiology, The Fourth Affiliated Hospital of Anhui Medical University, Hefei, China Department of Chemical and Biomolecular Engineering National University of Singapore 4 Engineering Drive 4 Singapore 117585 Singapore; Institute of Materials Research and Engineering 3 Research Link Singapore 117602 Singapore Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai, China State Key Laboratory for Powder Metallurgy, Central South University, Changsha 410083, China Key Laboratory of Theoretical Organic Chemistry and Functional Molecules Ministry of Education School of Chemistry and Chemical Engineering Hunan University of Science and Technology Xiangtan Hunan 411201 China School of Petroleum Engineering, China University of Petroleum (East China), Qingdao 266580, China; Key Laboratory of Unconventional Oil & Gas Development, China University of Petroleum (East China), Ministry of Education, Qingdao 266580, China Key Laboratory of Advanced Ceramics and Machining Technology (Ministry of Education) School of Materials Science and Engineering Tianjin University Tianjin 300072 China; Tianjin Key Laboratory of Composite and Functional Materials School of Materials Science and Engineering Tianjin University Tianjin 300072 China Department of Hand and Foot Surgery The First Hospital of Jilin University 1 Xinmin Street Changchun 130061 P. R. China Department of Anesthesia, UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, California. State Key Laboratory of Rare Earth Utilization Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 P. R. China Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore 117585; Institute of Materials Research and Engineering (IMRE), 2 Fusionopolis Way, Innovis, Singapore 136834 Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R.China. Tianjin Key Laboratory of Microbial Functional Genomics, Tianjin 300457, PR China; TEDA School of Biological Sciences and Biotechnology, Nankai University, 23 Hongda Street, TEDA, Tianjin 300457, PR China State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, No. 2699 Qianjin Avenue, Changchun, 130012, China Jiamusi College, Heilongjiang University of Chinese Medicine, Jiamusi, China. Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive, Singapore 117576; Institute of Materials Research Engineering, 3 Research Link, Singapore 117602 Jiamusi College; Heilongjiang University of Chinese Medicine; Jiamusi 154007; China Department of Physics, the Chinese University of Hong Kong, Shatin, Hong Kong, China Department of Oncology, Affiliated Hospital of Hebei University, Baoding, Hebei 071000, P.R. China Institute of Optics and Electronics Chinese Academy of Science; University of Chinese Academy of Sciences Key Laboratory of Lunar and Deep Space Exploration, National Astronomical Observatories, Chinese Academy of Sciences , Beijing 100101 , China Department of Chemical and Biomolecular Engineering, 4 Engineering Drive 4, National University of Singapore, Singapore 117576 University of Chinese Academy of Sciences; Xi'an Institute of Optics and Precision Machinery of CAS TEDA Institute of Biological Sciences and Biotechnology, Nankai University, 23 Hongda Street, TEDA, Tianjing 300457, China; The Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, 23 Hongda Street, TEDA, Tianjin 300457, China; Tianjin Key Laboratory of Microbial Functional Genomics, 23 Hongda Street, TEDA, Tianjin 300457, China Graduate School, Southwest Medical University, Luzhou, Sichuan 646000, China; Department of General Surgery, The Second Affiliated Hospital of Chengdu Medical College, China National Nuclear Corporation 416 Hospital, Chengdu, Sichuan 610051, China Center for Optical Coherence Tomography and Optical Physics, Department of Orthopedic Surgery, Brigham and Women’s Hospital, 75 Francis Street, Boston, MA 02115, USA; Harvard Medical School, Boston, MA 02115, USA Department of Spine Surgery, Third Affiliated Hospital, Sun Yatsen University, Guangzhou, China Center for Molecular Systems and Organic Devices (CMSOD) Key Laboratory for Organic Electronics and Information Displays and Institute of Advanced Materials (IAM) Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM) Nanjing University of Posts and Telecommunications 9 Wenyuan Road Nanjing 210023 China The National Key Facility for Crop Gene Resources and Genetic Improvement (NFCRI)/Key Lab of Germplasm Utilization (MOA) Institute of Crop Sciences Chinese Academy of Agricultural Sciences Beijing China Chengdu WestChina-Frontier Pharmatech Co., Chengdu 610041, China School of Chemical and Biomedical Engineering Nanyang Technological University Singapore Singapore; Division of Chemistry and Biological Chemistry School of Physical and Mathematical Sciences Nanyang Technological University 21 Nanyang Link Singapore 637371 Singapore Department of Pediatric Cardiology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, P.R. China College of Food Science and Engineering, Northwest A&F University, Yangling, China. State Key Laboratory of Elemento-organic Chemistry, Institute of Elemento-organic Chemistry, Nankai University, Tianjin 300071, People’s Republic of China Institute of Neurobiology, College of Nursing, Henan University, Kaifeng 475000, China. lbgood5912@sina.com. Key Laboratory of Molecular Microbiology and Technology of the Ministry of Education, TEDA College, Nankai University, Tianjin, People’s Republic of China; TEDA Institute of Biological Sciences and Biotechnology, Nankai University, Tianjin, People’s Republic of China; Tianjin Key Laboratory of Microbial Functional Genomics, TEDA College, Nankai University, Tianjin, People’s Republic of China Institute of Materials Research and Engineering (A*STAR); , Singapore 117602; Department of Chemical and Biomolecular Engineering; 4 Engineering Drive 4; National University of Singapore Department of Biomedical Engineering; School of Basic Medical Sciences; Nanjing Medical University; Nanjing 210029; China Contribution from the Department of Materials and Chemistry and Biochemistry, Institute for Polymers and Organic Solids, University of California at Santa Barbara, Santa Barbara, California 93106 Guangdong Provincial Key Laboratory of Sensor Technology and Biomedical Instrument, School of Biomedical Engineering, Sun Yat-sen University, Guangzhou 510006, PR China College of Biology, Hunan Province Key Laboratory of Plant Functional Genomics and Developmental Regulation, State Key Laboratory of Hunan University, Changsha 410082, China Key Laboratory of Developmental Genes and Human Diseases, MOE, Department of histology and embryology, School of Medicine, Southeast University, Nanjing 210009, China State Key Laboratory for Manufacturing System Engineering, Xi’an Jiaotong University, Xi’an 710054, China; Shaanxi Key Laboratory of Intelligent Robots, Xi’an Jiaotong University, Xi’an 710049, China Department of Chemical and Biomolecular Engineering National University of Singapore Singapore 117585 Singapore; Institute of Materials Research and Engineering (IMRE) 2 Fusionopolis Way Innovis 136834 Singapore the Fourth Clinical Medical College of Guangzhou University of Chinese Medicine Guangzhou 510006, China. Key Laboratory of Flexible Electronics (KLOFE) and Institute of Advanced Materials (IAM) Nanjing Tech University (Nanjing Tech) 30 South Puzhu Road Nanjing 211816 China Key Laboratory of Theoretical Chemistry and Molecular Simulation of Ministry of Education, Hunan Province College Key Laboratory of QSAR/QSPR, School of Chemistry and Chemical Engineering; Hunan University of Science and Technology; Xiangtan; Hunan; 411201; China Department of Cardiology Xiangya Hospital Central South University Changsha People's Republic of China Department of Neurosurgery, Jining No.1 People’s Hospital, Jining, China Institute for Advanced Study, Shenzhen University, Shenzhen 518060, China Department of Chemical and Biomolecular Engineering, 4 Engineering Drive 4, National University of Singapore, 117567, Singapore Department of Chemical and Biomolecular Engineering; National University of Singapore, Singapore; Singapore 117585; Singapore Department of Pathology, The Basic Medical School of Chongqing Medical University, Chongqing 400016, P.R. China Department of Colorectal Surgery, Coloproctological Hospital of Shenyang, Shenyang, China. liubin_70128@163.com National Engineering Center of Dairy for Maternal and Child Health, Beijing Sanyuan Foods Co. Ltd, Beijing 100163, P. R. China; Beijing Engineering Research Center of Dairy, Beijing Sanyuan Foods Co. Ltd, Beijing 100163, P. R. China Bin Liu, Jin-Bao Zong, Department of Rheumatology, the Affiliated Hospital of Qingdao University Medical College, Qingdao 266003, Shandong Province, China. College of Biology; Hunan Province Key Laboratory of Plant Functional Genomics and Developmental Regulation; Hunan University; Changsha; PR China Radiology Department Affiliated Hospital of Chengde Medical College Chengde China Southern University of Science and Technology Department Materials Science and Engineering CHINA Neuropharmacology Section, National Institute of Environmental Health Science, National Institutes of Health National Laboratory of Molecular Biology, Shanghai Institute of Biochemistry, Academia Sinica, Shanghai 200031, China. School of Computer Science and Technology, Harbin Institute of Technology , Shenzhen, Guangdong 518055, China; School of Computer Science and Technology, Beijing Institute of Technology , Beijing 100081, China; Advanced Research Institute of Multidisciplinary Science, Beijing Institute of Technology , Beijing 100081, China Guangdong-Hong Kong-Macao Greater Bay Area, Center for Medical Device Evaluation and Inspection of NMPA , Shenzhen 518045, China School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China Department of Orthopedics, The Third Affiliated Hospital of Southern Medical University, Academy of Orthopedics, Guangdong Province, Guangzhou 510665, China Ministry of Education Key Laboratory of Biotherapy of Human Diseases, Biotherapy and Research Center of Cancer, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, PR China. Center of Teaching & Experiment, Fourth Military Medical University,Xi'an 710032,China. Institute of Engineering Thermophysics, Chinese Academy of Sciences, Beijing 100190, China; Nanjing Institute of Future Energy System, Nanjing 211135, China Department of Geriatric Neurology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province, 650032, PR China; Yunnan Province Clinical Research Center for Gerontology, Kunming, Yunnan Province, 650032, PR China Department of Orthopaedics, Fuyang People's Hospital, Fuyang, Anhui Province, China Energy, Environment, and Economy (3E) Research Institute, Tsinghua University, Beijing 100084, China; State Key Laboratory of Military Stomatology Department of Oral Biology School of Stomatology, Fourth Military Medical University Xi'an 710032 People's Republic of China Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of the Ministry of Education; College of Chemistry and Materials Science; Northwest University; Xi’an 710069; China School of Chemistry and Environment and ‡Heeger Beijing Research and Development Center, Beihang University, Beijing 100191, P. R. China Key Laboratory for Organic Electronics & Information Displays (KLOEID), Institute of Advanced Materials (IAM), Nanjing University of Posts and Telecommunications (NUPT), Nanjing 210046, China Department of Assisted Reproduction, Xinhua Hospital, School of Medicine Shanghai Jiao Tong University Shanghai China Department of Orthopaedic Surgery, Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine Department of Respiratory Medicine, The First Affiliated Hospital, Hainan Medical University, Longhua, Haikou 570102, P. R. China; Hainan Province Clinical Medical Center of Respiratory Disease, Longhua, Haikou 579199, P. R. China; NHC Key Laboratory of Tropical Disease Control, Hainan Medical University, Haikou 571199, P. R. China Department of Cardiology, Second Hospital of Jilin University, Changchun, P. R. China Department of Molecular Diagnostics and Biopharmaceutics, College of Pharmaceutical Science, Soochow University, Suzhou, China. College of Food Science and Engineering, Ocean University of China Qingdao China Department of Vascular Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, China The Second Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang 550002, Guizhou, China. Department of Epidemiology and Health statistics, School of Public Health, Capital Medical University, Beijing, People’s Republic of China; Beijing Municipal Key Laboratory of Clinical Epidemiology, Beijing, China Department of Statistics and Data Science School of Management at Fudan University Shanghai China Department of Cardiology, the Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China Department of Chemical and Biomolecular Engineering National University of Singapore Singapore, 4 Engineering Drive 4 Singapore 117585 Singapore Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, Tianjin, People’s Republic of China; TEDA Institute of Biological Sciences and Biotechnology, Nankai University, Tianjin, People’s Republic of China; Center for Microbial Functional Genomics and Detection Technology, Ministry of Education, Tianjin, People’s Republic of China; Tianjin Key Laboratory of Microbial Functional Genomics, People’s Republic of China Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States Department of Microbiology, College of Life Sciences Nanjing Agricultural University, Key Laboratory of Agricultural and Environmental Microbiology, Ministry of Agriculture and Rural Affairs Nanjing China Characteristic Medical Center of Chinese People’s Armed Police Forces, Tianjin, People’s Republic of China Department of Vascular Surgery, Beijing Friendship Hospital Affiliated to Capital University of Medical Sciences, Beijing, China Cancer Hospital, Chinese Academy of Medical Sciences Beijing China Department of Emergency, Zhujiang Hospital, Southern Medical University, Guangzhou, China Department of Biochemistry, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China the Cardiovascular Disease Research Group, Departments of Pediatrics (B.L., R.S., G.D.L.) and Pharmacology (B.L., A.S.C., R.S., G.D.L.), The University of Alberta, Edmonton, Canada. Department of Pharmacodynamics College of Pharmacy University of Florida Gainesville FL USA Department of Physiology & Cell Biology, College of Medicine The Ohio State University Columbus OH USA; Davis Heart & Lung Research Institute The Ohio State University Columbus OH USA Respiratory and Critical Care Medicine, Tianjin Chest Hospital, Tianjin Cardiovascular Disease Research Institute, Tianjin 300222, China Institute of Tumor Molecular Biology, General Hospital of Guangzhou Command, Guangzhou 510010, China. Department of Intervention Medicine, the Second Hospital of Shandong University; Interventional Oncology Institute of Shandong University, Jinan, Shandong Province, People's Republic of China. Department of Hand and Foot Surgery, The First Hospital of Jilin University College of Forestry, Fujian Agriculture and Forestry University, Fuzhou, PR China College of Forestry Northwest A&F University Yangling China MOE Key Laboratory of Bioinorganic and Synthetic Chemistry School of Chemistry Sun Yat-Sen University Guangzhou 510275 China Department of Public Health Sciences, Henry Ford Health System, Detroit, MI Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Science Drive 4 117585, Singapore Department of Orthopedic Surgery, Brigham and Women’s Hospital, 75 Francis Street, Boston, MA 02115, USA; Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA Department of Chemistry; Purdue University; West Lafayette; USA College of Forestry, Fujian Agriculture and Forestry University, Fuzhou, China;; Camellia Oleifera Research Center at College of Forestry, Fujian Agriculture and Forestry University, Fuzhou, China;; Key Laboratory of National Forestry and Grassland Administration for Orchid Conservation and Utilization at College of Forestry, Fujian Agriculture and Forestry University, Fuzhou, China; School of Materials Science and Engineering Shanghai University Shanghai 200072 China Department of Pediatric Cardiology, West China Second Hospital, Sichuan University. Chengdu 610041, China. Department of Gynecology, Fujian Cancer Hospital, Teaching Hospital of Fujian Medical University, Fuzhou, Fujian 350014, P.R. China School of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, China. lbeddie@foxmail.com State Key Laboratory for Superlattices and Microstructures Institute of Semiconductors Chinese Academy of Sciences Beijing 100083 PR China; Wuhan National Laboratory for Optoelectronics (WNLO) and College of Optical and Electronic Information Huazhong University of Science and Technology (HUST) Wuhan 430074 PR China Public Health Sciences; Henry Ford Health System; Detroit Michigan State Key Laboratory of Powder Metallurgy, Central South University, Changsha, 410083, P. R. China Key Laboratory of Agricultural Environmental Microbiology, Ministry of Agriculture, College of Life Sciences, Nanjing Agricultural University, Nanjing, China Department of Critical Care Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical University Jinan 250021, Shandong, China. Department of Spine Surgery, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China; Guangdong Provincial Center for Quality Control of Minimally Invasive Spine Surgery, Guangzhou, China; Guangdong Provincial Center for Engineering and Technology Research of Minimally Invasive Spine Surgery, Guangzhou, China Key Laboratory of Metabolism and Molecular Medicine, Ministry of Education, and Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai, China; Hubei Key Laboratory for Kidney Disease Pathogenesis and Intervention, Hubei Polytechnic University School of Medicine, Huangshi, Hubei, China State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources/Guangdong Provincial Key Laboratory of Postharvest Science of Fruit and Vegetables/Engineering Research Center for Postharvest Technology of Horticultural Crops in South China, South China Agricultural University, Guangzhou 510642, China; College of Life Sciences, South China Agricultural University, Guangzhou 510642, China Department of Respiratory Diseases, Chinese PLA General Hospital, Beijing, China Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials Ministry of Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules College of Chemistry and Chemical Engineering Hubei University Wuhan 430062 P. R. China Department of Chemistry, Colorado State University, Fort Collins, Colorado 80523, United States The Zena and Michael A. Wiener Cardiovascular Institute and Department of Medicine, Mount Sinai School of Medicine, New York, New York Shouguang Fukang Pharmaceutical Co., Ltd., Weifang262700, P. R. China Medical Imaging Department of PLA 546 Hospital, Malan, Xinjiang, China (mainland) Department of Cancer Epidemiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100021, China Department of General Surgery The First Affiliated Hospital of Anhui Medical University Hefei China School of Stomatology, Lanzhou University, Lanzhou 730000, China Rice Research Institute Guangdong Academy of Agricultural Sciences Guangzhou China; Guangdong Provincial Key Laboratory of New Technology in Rice Breeding Guangdong Academy of Agricultural Sciences Guangzhou China School of Flexible Electronics (Future Technologies) (SoFE) and Institute of Advanced Materials (IAM) Nanjing Tech University (NanjingTech) 30 South Puzhu Road Nanjing 211816 China Institute of Materials Research Engineering; A*STAR; Singapore 117602; Department of Chemical and Biomolecular Engineering; National University of Singapore Key Laboratory of Synthetic and Natural Functional Molecule Chemistry (Ministry of Education), Department of Chemistry, Northwest University, Xìan, 710069, China Department of Molecular Genetics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA College of Materials Science & Technology, Nanjing University of Aeronautics & Astronautics, Nanjing, 211100, China Department of Radiology, The First Clinical College, Shandong University of Traditional Chinese Medicine, Jinan, Shandong 250033, P.R. China 4Department of Genetics, Center for Cancer Genetics and Genomics, The University of Texas MD Anderson Cancer Center, Houston, Texas. Key Laboratory of Precision Nutrition and Food Quality Department of Nutrition and Health China Agricultural University Beijing 100193 China Institute of Materials Research and Engineering, Agency for Science, Technology and Research (A*STAR), Singapore; Department of Chemical & Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore 117576 Institute for Food and Bioresource Engineering; College of Engineering; Peking University; Beijing 100871; China Department of Vascular Surgery, First Affiliated Hospital of Anhui Medical University, Hefei, China. The Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, Tianjin, People’s Republic of China; TEDA Institute of Biological Sciences and Biotechnology, Nankai University, TEDA, Tianjin, People’s Republic of China; Center for Microbial Functional Genomics and Detection Technology, Ministry of Education, Tianjin, People’s Republic of China; Tianjin Key Laboratory of Microbial Functional Genomics, Tianjin, People’s Republic of China College of Food Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China Institute for Metabolic & Neuropsychiatric Disorders Binzhou Medical University Hospital Binzhou China Department of Materials Science and Engineering; The Shenzhen Key Laboratory for Printed Organic Electronics; Southern University of Science and Technology (SUSTech); Shenzhen; China 3Department of Human Genetics, The University of Texas MD Anderson Cancer Center, Houston, Texas. Aab Cardiovascular Research Institute, University of Rochester, School of Medicine and Dentistry, NY (S.C., B.L., C.Y.). Department of Chemistry and Key laboratory for Preparation and Application of Ordered Structural Materials of Guangdong Province Shantou University Guangdong 515063 P. R. China Department of Respiratory and Critical Care, Tianjin Chest Hospital, Tianjin 300222, China. Department of Spine surgery The Fifth Affiliated Hospital, Sun Yat‐sen University Zhuhai Guangdong China National Key Laboratory of Plant Genomics and Center for Plant Gene Research, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China (B.L., P.L., C.L., S.C., C.C., X.C.); Graduate School of the Chinese Academy of Sciences, Beijing 100039, China (B.L., P.L.); and China Agricultural University, Beijing 100094, China (X.L.) Key Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM) Nanjing Tech University (NanjingTech) 30 South Puzhu Road Nanjing 211816 China Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai, China, Key Laboratory of Agricultural Environmental Microbiology, Ministry of Agriculture, College of Life Sciences, Nanjing Agricultural University, Nanjing, Jiangsu, People's Republic of China Molecular Oncology Laboratory, Department of Orthopaedic Surgery and Rehabilitation Medicine, The University of Chicago Medical Center, Chicago, Illinois 60637, United States; School of Life Sciences, Southwest University, Chongqing, 400715, China School of Chemical Engineering and Technology, Key Laboratory for Green Chemical Technology of Ministry of Education, Collaborative Innovation Center of Chemical Science and Engineering, Tianjin University, Tianjin 300072, China Shenyang National Laboratory for Materials Science; Institute of Metal Research; Chinese Academy of Sciences; Shenyang; China 1Eureka Therapeutics Inc., Emeryville, California. Department of Radiology, Beijing YouAn Hospital Capital Medical University, Beijing 100069, China; Department of Radiology, Civil Aviation General Hospital, Beijing 100123, China Department of Gynecology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, China Department of Materials Science and Engineering Center of Super‐Diamond and Advanced Films (COSDAF) City University of Hong Kong Tat Chee Avenue Kowloon Hong Kong China National Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University Guangzhou 510060, China. Department of Urology, Third Xiangya Hospital, Changsha 410013, China. Institute of Materials Research and Engineering; A*STAR; , Singapore 117602; Department of Chemical and Biomolecular Engineering; National University of Singapore Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry; University of Science and Technology of China; Hefei, China Department of Internal Medicine College of Medicine–PhoenixUniversity of Arizona Phoenix AZ; Translational Cardiovascular Research CenterCollege of Medicine–PhoenixUniversity of Arizona Phoenix AZ School of Computer Science and Technology, Beijing Institute of Technology , Beijing 100081 , China; Advanced Research Institute of Multidisciplinary Science, Beijing Institute of Technology , Beijing 100081 , China Vertex, Boston, Massachusetts, USA Department of PharmacodynamicsCollege of PharmacyUniversity of Florida Gainesville Florida USA West China Hospital of Sichuan University, Chengdu, Sichuan, China. liubinhxyy@163.com Jiangxi University of Traditional Chinese Medicine, Nanchang, Jiangxi 330004, People’s Republic of China State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University , Guangzhou 510120 , China; Guangzhou Laboratory , Bio-Island, Guangzhou 510320 , China Key Laboratory of Macromolecular Science of Shaanxi Province; School of Materials Science and Engineering; Shaanxi Normal University; Xi'an; China A Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, Shaanxi Key Laboratory of Physico-Inorganic Chemistry, College of Chemistry and Materials Science, Northwest University, Xi’an 710127, P. R. China Key Laboratory of Superlight Materials and Surface Technology, Ministry of Education, College of Material Sciences and Chemical Engineering, Harbin Engineering University, Harbin 150001, P. R. China; State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China State Key Laboratory of Organic Electronics and Information Displays & School of Chemistry and Life Sciences & Institute of Advanced Materials (IAM) Nanjing University of Posts & Telecommunications Nanjing 210023 China School of Advanced Materials, Peking University Shenzhen Graduate School, Peking University, Shenzhen 518055, China; Department of Materials Science and Engineering, Southern University of Science and Technology (SUSTech), No. 1088, Xueyuan Road, Nanshan, Shenzhen, Guangdong 518055, China College of Food Science Fujian Agriculture and Forestry Univ Fuzhou Fujian 350002 China; Natl. Engineering Research Center of Juncao Fuzhou Fujian 350002 China Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing 100069, China; Beijing Municipal Key Laboratory of Clinical Epidemiology, Beijing, China Department of Emergency The Fifth Central Hospital in Tianjin Tianjin China College of Forestry Northwest A and F University Yangling Shaanxi China School of Environment and Safety Engineering; North University of China; Taiyuan; China Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94143-0448, USA. School of Advanced Materials, Peking University Shenzhen Graduate School, Shenzhen 518055, China College of Forestry, Jiangxi Agricultural University/Key Laboratory of National Forestry and Grassland Administration on Forest Ecosystem Protection and Restoration of Poyang Lake Watershed, Nanchang 330045, China. Jiulianshan National Observation and Research Station of Chinese Forest Ecosystem, Nanchang 330045, China. Administration of Jiulianshan National Nature Reserve, Ganzhou 341700, Jiangxi, China. Beijing Advanced Innovation Center for Food Nutrition and Human Health; Key Laboratory of Functional Dairy; College of Food Science and Nutritional Engineering; China Agricultural University; China Department of Materials Science and Engineering City University of Hong Kong Hong Kong 999077 China Department of Chemistry, National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Taiwan School of Chemical and Biological Engineering, Lanzhou Jiaotong University, Lanzhou 730070, China The Cardiac Surgery Department, The First Hospital of Jilin University, Changchun 130021, China Institute of Materials Research and Engineering; A*STAR; Singapore; Department of Chemical and Biomolecular Engineering; National University of Singapore Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai, China Department of Clinical Laboratory, The First Affiliated Hospital of Xinjiang Medical University , Urumqi , China Department of Otorhinolaryngology Head and Neck Surgery, Hunan Provincial People's Hospital, Changsha 410005, P.R. China. School of Chinese Pharmacology, Beijing University of Chinese Medicine, Beijing 100102, China. liubinyn67@163.com Division of Sports Medicine and Adult Reconstructive Surgery, Department of Orthopedic Surgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, 321 Zhongshan Road, Nanjing, Jiangsu, 210008, P. R. China. State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, 22 Hankou Road, Nanjing, Jiangsu, 210093, P. R. China. Branch of National Clinical Research Center for Orthopedics, Sports Medicine and Rehabilitation, 321 Zhongshan Road, Nanjing, Jiangsu, 210008, P. R. China. School of Chemical and Biomedical Engineering Nanyang Technological University Singapore 637459 Singapore), E-mail: Bin Liu Department of Nuclear Medicine, the Affiliated Hospital of Qingdao University, Qingdao, Shandong�266003, P.R. China Department of Plasma Proteins, Institute of Blood Transfusion, Chinese Academy of Medical Sciences, Chengdu, Sichuan, China (mainland) The Key Laboratory of Advanced Photonic and Electronic Materials School of Electronic Science and Engineering Nanjing University Nanjing 210033 P. R. China Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Laboratory of Molecular Bacteriology, KU Leuven , Leuven B-3000, Belgium TEDA Institute of Biological Sciences and Biotechnology, Nankai University, Tianjin Economic-Technological Development Area, Tianjin 300457, People’s Republic of China;; Tianjin Research Center for Functional Genomics and Biochip, Tianjin 300457, People’s Republic of China; Key Laboratory for Organic Electronics and Information Displays and Institute of Advanced Materials, Nanjing University of Posts and Telecommunications, Nanjing 210023, China Department of Chemical and Biomolecular Engineering, National University of Singapore, Singapore 117576, Singapore; Institute of Materials Research and Engineering (A*STAR), 3 Research Link, Singapore 117602, Singapore From The Dorothy M. Davis Heart & Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus (J.C., M.A.M., S.C.L., H.M., B.L., X.W., I.P., J.S.A., P.W., J.L., G.E.B., S.G., T.J.H., P.J.M.); Departments of Internal Medicine (P.J.M.) and Physiology and Cell Biology (J.C., M.A.M., S.C.L., H.M., B.L., P.W., G.E.B., S.G., P.J.M.), The Ohio State University, Columbus; Department of Biomedical Engineering, The Ohio State University College of Engineering, Columbus (T.J.H.);... 1Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California. Department of Rheumatology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China; Persistent Organic Pollution Laboratory, Shenzhen Center for Disease Control and Prevention, Shenzhen 518055, China. Department of Chemical and Biomolecular Engineering, 4 Engineering Drive 4, National University of Singapore, Singapore 117567, Singapore State Key Laboratory of Heavy Oil Processing China University of Petroleum (East China) Qingdao 266580 PR China Graduate Program in Chinese Academy of Medical Sciences and Peking Union Medical College, China.; National Institute of Biological Sciences, No. 7 Science Park Road, Zhongguancun Life Science Park, Beijing 102206, China. TEDA School of Biological Sciences and Biotechnology, Tianjin Key Laboratory of Microbial Functional Genomics, Tianjin Research Center for Functional Genomics and Biochip, the Key Laboratory of Molecular Microbiology and Technology, Ministry of Education Nankai University 23 Hongda Street, TEDA Tianjin 300457 China Department of Hematology, Institute of Hematology, Changhai Hospital, Second Military Medical University State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry Changchun 130022 P. R. China Department of Pediatrics‑Oncology, Baylor College of Medicine, Texas Children's Hospital, Houston, TX 77030, USA Department of Pathology, Lanzhou General Hospital of the People's Liberation Army, Lanzhou, Gansu 730050, P.R. China College of Forestry, Fujian Agriculture and Forestry University, Fuzhou, China Institute of Radiation Medicine, Chinese Academy of Medical Sciences, Peking Union Medical College, Tianjin 300000, China Centre for Systems Chemistry Stratingh Institute University of Groningen Nijenborgh 4 9747 AG Groningen The Netherlands Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu, China Department of Biobank, Bao’an Maternal and Child Health Hospital, Jinan University, Shenzhen 518102, Guangdong, China School of Material Science and Engineering, University of Jinan, Jinan, China School of Computer Science and Technology, Harbin Institute of Technology , Shenzhen, Guangdong, China; School of Computer Science and Technology, Beijing Institute of Technology , Beijing, China Department of General Surgery, Huashan Hospital Affiliated to Fudan University Shanghai 200040, China. School and Hospital of Stomatology, Lanzhou University, No. 222 Tianshui South Road, Chengguan District, Lanzhou 730000, Gansu, P. R. China School of Physics and Optoelectronics & Hunan Institute of Advanced Sensing and Information Technology, Xiangtan University, Xiangtan, Hunan 411105, P. R. China Department of Materials Science and Engineering Shanghai Jiao Tong University Shanghai 200240 China The Second Hospital of Jilin University, Changchun, China Dept of Chemical and Biomolecular Engineering National University of Singapore 117585 Singapore; Institute of Materials Research and Engineering, Agency for Science, Technology and Research (A*STAR) Innovis Singapore 138634 grid.216938.7 0000000098787032 TEDA Institute of Biological Sciences and Biotechnology Nankai University, TEDA 300457 Tianjin People’s Republic of China; grid.419897.a 000000040369313X Key Laboratory of Molecular Microbiology and Technology Ministry of Education 300071 Tianjin People’s Republic of China; Tianjin Key Laboratory of Microbial Functional Genomics 300457 Tianjin People’s Republic of China Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, China Department of Pharmacy Liaoning University Shenyang People's Republic of China Department of Hand and Foot Surgery, First Hospital of Jilin University, Changchun, China Department of Rheumatology and Immunology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China School of Medicine, Shanghai Jiao-Tong University, Shanghai 200025, China TEDA School of Biological Sciences and Biotechnology, Nankai University; Tianjin Key Laboratory of Microbial Functional Genomics; The Engineering and Research Center for Microbial Functional Genomics and Detection Technology, Ministry of Education First Department of Neurology, Hospital Affiliated to Hebei United University, Tangshan 063000, Hebei Province, China. Key Laboratory of Advanced Photonic and Electronic Materials, School of Electronic Science and Engineering, Nanjing University, Nanjing 210093, China Shanghai Key Laboratory of Intelligent Information Processing, Shanghai, China; School of Computer Science and Technology, Harbin Institute of Technology Shenzhen Graduate School, Shenzhen, Guangdong, China Department of Orthopedics; Xijing Hospital; Fourth Military Medical University; Xi'an; P. R. China Institute of Clean Chemical Engineering, College of Chemistry and Chemical Engineering, Taiyuan University of Technology, Taiyuan 030024, China Department of Medical Oncology, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science & Technology of China, No. 55, Section 4, Renmin South Road, Chengdu, Sichuan Province, China Beijing Institute of Technology, 47833 Beijing, Beijing, China, 100081 (e-mail: bliu@insun.hit.edu.cn) Key Laboratory of Superlight Materials and Surface Technology, Ministry of Education, College of Materials Sciences and Chemical Engineering, Harbin Engineering University, Harbin150001, People’s Republic of China College of Biology, Hunan University, Changsha, 410082, China; Department of Physiology & Pathophysiology, NHC Key Laboratory of Metabolic Cardiovascular Diseases Research, School of Basic Medical Sciences, Ningxia Medical University, Yinchuan, 750004, China Department of Biochemistry, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China; School of Chemical and Biomedical Engineering; Nanyang Technological University; Singapore 637459, Singapore Department of Urology, the First Hospital of Jilin University, Changchun 130021, Jilin, China State Key Laboratory of Elemento-Organic Chemistry, Research Institute of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, People's Republic of China Department of Neurology The First Affiliated Hospital of Shandong First Medical University Jinan China; Shandong Institute of Neuroimmunology Jinan China University of California Department of Chemistry, , Santa Barbara, California 93106 Key Laboratory of Macromolecular Science of Shaanxi Province, School of Materials Science and Engineering, Shaanxi Normal University, Xi’an 710119, China School/Hospital of Stomatology, Lanzhou University, Lanzhou, China Affiliations of authors: Departments of Genetics and The Center for Genetics and Genomics (BL, XR, GL), Pathology (YM, AKEN), Head and Neck Surgery (MZ), Thoracic/Head and Neck Medical Oncology (JianjZ), and Genomic Medicine (JianjZ, JianhZ, PAF), The University of Texas MD Anderson Cancer Center, Houston, TX College of Veterinary Medicine, Qingdao Agricultural University, Qingdao 266109, China Department of Materials Science and Engineering, International Institute of Nanotechnology, Northwestern University, Evanston, Illinois 60208, United States School of Stomatology, Lanzhou University, Lanzhou, 730000, P. R. China Department of Urology, China‑Japan Union Hospital of Jilin University, Changchun, Jilin 130033, P.R. China Agricultural Resources and Environment Institute, Guangxi Academy of Agricultural Sciences, Nanning 530007, China. Department of Neurology, Suzhou First People’s Hospital, Suzhou, Anhui Province, China Beijing Institute of Genomics of Chinese Academy of Sciences, Beijing Genomics Institute, Beijing Proteomics Institute, 101300, Beijing, China Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen 518055, China Environmental Quality Forecast Center, China National Environmental Monitoring Center, 100012 Beijing, China; From the Department of Spine Surgery, Institute of Drug Clinical Trial for Orthopedic Diseases, The Third Affiliated Hospital of Sun Yat-sen University; Guangdong Provincial Center for Engineering and Technology Research of Minimally Invasive Spine Surgery; and Guangdong Provincial Center for Quality Control of Minimally Invasive Spine Surgery, Guangzhou, China. Department of Cardiology, The Second Hospital of Jilin University, Changchun 130041, Jilin Province, China Department of Urinary Surgery, The Fourth Hospital of Hebei Medical University, No. 12 Jiankang Road, 050000, China Department of Materials Science and Engineering, Southern University of Science and Technology (SUSTech), Shenzhen 518055, Guangdong, China Zhejiang Province Key Laboratory of Noble Metal Catalytic Materials and Technology; Hangzhou; China Key Laboratory of High Magnetic Field and Ion Beam Physical Biology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, People’s Republic of China; University of Science and Technology of China, Hefei 230026, People’s Republic of China College of Food Science; Fujian Agriculture and Forestry University; Fuzhou; China School of Computer Science and Technology, Harbin Institute of Technology Shenzhen Graduate School, Shenzhen, Guangdong, China; Key Laboratory of Network Oriented Intelligent Computation, Harbin Institute of Technology Shenzhen Graduate School, Shenzhen, Guangdong, China; Gordon Life Science Institute, Belmont, MA, USA Key Laboratory of In-Fiber Integrated Optics; Ministry Education of China; and College of Physics and Opotoelectronic Engineering; Harbin Engineering University; Harbin 150001 Center of Super Diamond and Advanced Films (COSDAF); Department of Materials Science and Engineering; City University of Hong Kong; HKSAR; China Institute of Bioinformatics and Medical Engineering, School of Electrical and Information Engineering Jiangsu University of Technology Changzhou China College of Forestry, Shenyang Agricultural University, Shenyang 110866, China Department of Spine Surgery, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou Guangdong, 510630, P. R. China. Department of Biochemistry, Zhongshan School of Medicine Sun Yat‐sen University Guangzhou China State Key Laboratory of Crop Stress Biology in Arid Areas and College of Agronomy, Northwest A&F University, Xianyang 712100, China State Key Laboratory of Supramolecular Structure and Materials College of Chemistry Jilin University Qianjin Street Changchun China Department of Nuclear Medicine, West China Hospital, Sichuan University, No. 37 Guoxue Alley, Chengdu, Sichuan 610041, China. Department of Chemical and Biomolecular Engineering National University of Singapore 4 Engineering Drive 4 11758 Singapore; Institute of Materials Research and Engineering A*STAR 3 Research Link 117602 Singapore Department of Obstetrics and Gynecology, The Sixth Medical Center, Chinese PLA General Hospital, Beijing, PR China School of Materials Science and Engineering, North University of China, Taiyuan 030051, China Xi’an Institute of Optics and Fine Mechanics, Chinese Academy of Sciences, Xi’an 710119, China College of Food Science, Fujian Agriculture and Forestry Univ. Fuzhou Fujian 350002 China; Natl. Engineering Research Center of Juncao Fuzhou Fujian 350002 China Gansu Provincial Hospital, Lanzhou 730000, China TEDA School of Biological Sciences and Biotechnology, Nankai University, 23 Hongda Street, TEDA, Tianjin 300457, People's Republic of China Zernike Institute for Advanced Materials, University of Groningen, Nijenborgh 4, 9747 AG Groningen, The Netherlands Institute of Translational Medicine Research, Tianjin Union Medical Center, TEDA Institute of Biological Sciences and Biotechnology, Nankai University, Tianjin, China.; Key Laboratory of Molecular Microbiology and Technology, Nankai University, Ministry of Education, Tianjin, China.; Center for Microbial Functional Genomics and Detection Technology, Ministry of Education, Tianjin, China. Wuhan National Laboratory for Optoelectronics (WNLO) and College of Optical and Electronic Information, Huazhong University of Science and Technology (HUST), Wuhan 430074, P. R. China; State Key Laboratory for Superlattices and Microstructures, Institute of Semiconductors, Chinese Academy of Sciences, Beijing 100083, P. R. China Department of Gastroenterology, The Second Hospital of Shandong University, Jinan, Shandong 250033, P.R. China Shenzhen Key Laboratory of Food Nutrition and Health, Institute for Innovative Development of Food Industry, Department of Food Science and Engineering, College of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen, China; Shenzhen Key Laboratory of Marine Microbiome Engineering, Shenzhen University, Shenzhen, China US Army Institute of Surgical Research JBSA‐Fort Sam Houston San Antonio Texas USA Cardiovascular Research Center, Shantou University Medical College, Shantou, China; and College of Life Science, Jiangxi Normal University, Nanchang, PR China Department of Chemical and Biomolecular Engineering National University of Singapore 4 Engineering Drive 4 117585 Singapore; Institute of Materials Research and Engineering (IMRE) 2 Fusionopolis Way Innovis 136834 Singapore State Key Laboratory of Cellular Stress Biology, School of Life Sciences Xiamen University Xiamen PR China Pen-Tung Sah Institute of Micro-Nano Science and Technology, Xiamen University, Xiamen 361000, China Shenzhen Key Laboratory of Food Nutrition and Health, Shenzhen Key Laboratory of Marine Microbiome Engineering, Institute for Advanced Study, Shenzhen University, Shenzhen 518060, China; Institute for Innovative Development of Food Industry, Shenzhen University, Shenzhen518060, China Ecloud@tom.com Department of Neurology, Shandong Provincial Qianfoshan Hospital , Jinan, Shandong, China School of Computer Science and Technology, Harbin Institute of Technology Shenzhen Graduate School, Shenzhen, Guangdong, China; Key Laboratory of Network Oriented Intelligent Computation, Harbin Institute of Technology Shenzhen Graduate School, Shenzhen, Guangdong, China Third Affiliated Hospital of Sun Yat-Sen University, 144991, Department of Spine Surgery, Guangzhou, Guangdong, China; Guangdong Provincial Center for Engineering and Technology Research of Minimally Invasive Spine Surgery, Guangzhou, Guangdong, China; Guangdong Provincial Center for Quality Control of Minimally Invasive Spine Surgery, Guangzhou, Guangdong, China; Department of Chemical and Biomolecular Engineering National University of Singapore 4 Engineering Drive 4 117585 Singapore Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230012, P.R. China Department of Molecular Biology, The Scripps Research Institute, MB-8, 10550 North Torrey Pines Road, La Jolla, California 92037, and Stanford Synchrotron Radiation Laboratory, 2575 Sand Hill Road, Menlo Park, California 94025 Department of Internal Medicine-Oncology, The Affilicated Hosptial of Hebei University Hebei, China. The University of Iowa Department of Physics and Astronomy, , Iowa City, Iowa 52242, USA Key Laboratory of Superlight Materials and Surface Technology, Ministry of Education, College of Material Sciences and Chemical Engineering, Harbin Engineering University, Harbin, 150001, P. R. China Institute of Nano Biomedicine and Engineering; Shanghai Engineering Research Centre for Intelligent Diagnosis and Treatment Instrument; Department of Instrument Science and Engineering; School of Electronic Information and Electrical Engineering; Shanghai Jiao Tong University Guangzhou New Centre Institute of Vitiligo, Guangzhou, PR China; School of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, China. lbeddie@hotmail.com Department of Industrial Engineering, Tsinghua University, Beijing, China Department of Chemistry, Capital Normal University, Beijing, 100048, China From the *The School of Nuclear Science and Technology, Lanzhou University; Departments of †Radiology and ‡Pathology, Lanzhou University Second Hospital; and §School of Stomatology, Lanzhou University, Lanzhou, China. School/Hospital of Stomatology, Lanzhou University, Lanzhou, Gansu 730000, P.R. China Research Institute of Subtropical Forestry Chinese Academy of Forestry Hangzhou China; Zhejiang Provincial Key Laboratory of Tree Breeding Hangzhou China Department of Nuclear Medicine , West China Hospital , Sichuan University , Chengdu , P.R. China Department of NeurosurgeryìPeking University Third Hospital, Beijing 100083, China. Department of Chemical and Biomolecular Engineering, National University of Singapore, Singapore; Joint School of National University of Singapore and Tianjin University, International Campus of Tianjin University, China Institute of Applied Micro-Nano Materials, School of Science, Beijing Jiaotong University, Beijing 100044, China Department of Genetics, The University of Texas MD Anderson Cancer Center, Houston, Texas Wuxi People's Hospital Affiliated to Nanjing Medical University, Wuxi Dept. of Oral Biology, School of Stomatology, The Fourth Military Medical University, Xi'an 710032, China. Tianjin Medical College, Tianjin 300052, China. binliu@public.tpt.tj.cn Center of Super-Diamond and Advanced Films (COSDAF) & Department of Materials Science and Engineering, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong, China Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200030. China Hospital Development Institute, Shanghai Jiao Tong University, Shanghai, 200030. The Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, Nankai University, Tianjin 300457, China; Tianjin Key Laboratory of Microbial Functional Genomics, TEDA Institute of Biological Sciences and Biotechnology, Nankai University, Tianjin 300457, China; Nankai International Advanced Research Institute, Shenzhen 518045, China State Key Laboratory of Elemento-Organic Chemistry, Research Institute of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, People’s Republic of China Laboratory of Hepatobiliary Surgery of Affiliated Hospital of Guangdong Medical College, Zhanjiang Key Laboratory of Hepatobiliary Diseases, Zhanjiang 524001, China Department of Medical Oncology, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science & Technology of China, Chengdu, 610041, Sichuan, PR China Center for Medical Device Evaluation NMPA Beijing China Institute of Agricultural and Environmental Sciences, Estonian University of Life Sciences, Tartu, Estonia Department of Thoracic Oncology, Sichuan Provincial Cancer Hospital, Chengdu, China Ansaris, Four Valley Square, 512 East Township Line Road, Blue Bell, Pennsylvania 19401, United States Department of Cancer Epidemiology Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guizhou University, Huaxi District, Guiyang 550025, China Key Laboratory of Dental Maxillofacial Reconstruction and Biological Intelligence Manufacturing, Gansu Province, School of Stomatology, Lanzhou University, Lanzhou 730000, P.R. China Sichuan Dekon Livestock Foodstuff Group, Chengdu 610200, China Institute of Engineering Thermophysics; Chinese Academy of Sciences; Beijing 100190; China Department of Cardiology, The Second Hospital of Jilin University, Changchun, People’s Republic of China Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, 117585, Singapore Neuropharmacology SectionLaboratory of Pharmacology and ChemistryNational Institute of Environmental Health SciencesNational Institutes of Health Research Triangle Park North Carolina 27709 National Academy of Agriculture Green Development, College of Resources and Environmental Sciences, China Agricultural University, Beijing 100193, P. R. China School/Hospital of Stomatology Lanzhou University, Lanzhou 730000, China Department of Chemical and Biomolecular Engineering National University of Singapore 4 Engineering Drive 4 Singapore 117576; Institute of Materials Research and Engineering 3 Research Link Singapore 117602 Department of Pediatrics The Affiliated Hospital of Southwest Medical University Luzhou China TEDA Institute of Biological Sciences and Biotechnology, Nankai University, Tianjin 300457, China; Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, Nankai University, Tianjin 300457, China; Nankai International Advanced Research Institute, Nankai University, Shenzhen 518000, China Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry & University of Chinese Academy of Sciences, Chinese Academy of Sciences, Beijing 100190, People’s Republic of China Department of Materials Science and Engineering, City University of Hong Kong, Hong Kong SAR 999077, China Department of Chemistry, ‡Center for Bioactive Delivery, Institute for Applied Life Sciences, University of Massachusetts, Amherst, Massachusetts 01003, United States Guangdong Key Laboratory of New Technology in Rice Breeding, Rice Engineering Laboratory Rice Research Institute, Guangdong Academy of Agricultural Sciences Guangzhou China College of Material Science and Engineering; Huaqiao University; Xiamen 361021; China Department of Chemistry and Maurice Morton Institute of Polymer Science, ‡Department of Biomedical Engineering, and §Department of Biology, The University of Akron, Akron, Ohio 44325, United States Department of Interventional Medicine, the Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong Province, People’s Republic of China; Interventional Oncology Institute of Shandong University, Jinan, Shandong Province, People’s Republic of China National Research Center for Stem Cell Engineering & Technology, State Key Laboratory of Experimental Hematology, Institute of Hematology, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, People's Republic of China Key Laboratory of Freshwater Fish Reproduction and Development, Ministry of Education, School of Life Sciences, Southwest University, Chongqing 400715, China Cardiovascular Research Center, Shantou University Medical College, 22 Xin-Ling Rd, Shantou, 515041, China Nanjing University Department of Emergency, The Affiliated Nanhua Hospital, University of South China, Hengyang, Hunan, China 1 School of Computer Science and Technology,; 2 Key Laboratory of Network Oriented Intelligent Computation, Harbin Institute of Technology Shenzhen Graduate School, Shenzhen, Guangdong 518055, China,; 3 Computational Biology, Gordon Life Science Institute, Belmont, MA 02478, USA, Department of Radiology, The First Affiliated Hospital of Anhui Medical University, China. lbhyz32188@126.com Departments of Chemistry and Biochemistry and Materials, Institute for Polymers and Organic Solids, University of California, Santa Barbara, CA 93106 College of Pulmonary and Critical Care Medicine Chinese PLA General Hospital Beijing 100853 China Key Laboratory of Noise and Vibration Research, Institute of Acoustics Chinese Academy of Sciences Beijing People's Republic of China Key Laboratory of Synthetic and Natural Functional Molecule Chemistry (Ministry of Education), Shaanxi Key Laboratory of Physico-Inorganic Chemistry, Department of Chemistry, Northwest University, Xi’an, 710069, China Department of Chemical and Biomolecular Engineering, Faculty of Engineering, National University of Singapore, 10 Kent Ridge Crescent, Singapore 119260 Department of Otolaryngology and Head and Neck Surgery, Hunan Provincial People's Hospital, First Affiliated Hospital of Hunan Normal University, Changsha, Hunan 410007, P.R. China Division of Chemical and Biomolecular Engineering, School of Chemical and Biomedical Engineering, Nanyang Technological University, 62 Nanyang Drive, Singapore 637459, Singapore Department of Materials Science and Engineering Southern University of Science and Technology (SUSTech) Shenzhen Guangdong 518055 China; Guangdong Provincial Key Laboratory of Functional Oxide Materials and Devices Southern University of Science and Technology (SUSTech) Shenzhen Guangdong 518055 China 1Department of Anesthesia, University of California, San Francisco, San Francisco, California.; 2Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California. Department of Cardiology, the Second Hospital of Jilin University, Changchun, China. Department of General Surgery, General Hospital of Tianjin Medical University, Tianjin 300052, China Department of Hand Surgery, The First Hospital of Jilin University, Changchun, China. University of Chinese Academy of Sciences; Chinese Academy of Sciences; State Key Laboratory of Applied Optics Department of Pharmacology, School of Pharmaceutical Sciences, Central South University, Changsha, China Tianjin Key Laboratory of Refrigeration Technology Tianjin University of Commerce Tianjin China Department of Laboratory Medicine, The Fifth People's Hospital of Wuxi, Wuxi, Jiangsu 214005, P.R. China Northeastern University Qingdao Laoshan Tea Association, Qingdao, Shandong 266109, China Jiangxi Engineering Laboratory for Optoelectronics Testing Technology, Nanchang 330063, China; Key Laboratory of Non-destructive Testing, Ministry of Education, Nanchang Hangkong University, Nanchang 330063, China Prehistoric Department, Zhejiang Provincial Institute of Cultural Relics and Archaeology, 310014 Hangzhou, China; Department of Neurology The Second Affiliated Hospital of Chongqing Medical University Chongqing China Department of Vascular Surgery, The Second Affiliated Hospital of Shandong First Medical University, Tai’an 271000, China Second Affiliated Hospital of Ji Lin University, Changchun, China. TEDA Institute of Biological Sciences and Biotechnology, Nankai University, TEDA, Tianjin, P. R. China; The Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, Tianjin, P. R. China Department of Epidemiology, School of Public Health Zhejiang Chinese Medical University Hangzhou China b Department of Obstetrics and Gynecology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, People's Republic of China Management Office of Dafeng Milu National Nature Reserve, Yancheng, 224136, China TEDA Institute of Biological Sciences and Biotechnology Nankai University Tianjin China; The Key Laboratory of Molecular Microbiology and Technology Ministry of Education Tianjin China; Tianjin Key Laboratory of Microbial Functional Genomics Tianjin China School of Mechanical Engineering, Northwestern Polytechnical University, Xi'an 710072, China The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Shandong University Qilu Hospital, Jinan, Shandong, 250012, China. Department of Materials Science and Engineering Southern University of Science and Technology (SUSTech) Shenzhen 518055 China Laboratory Animal Center, State Key Laboratory of Military Stomatology, School of Stomatology, The Fourth Military Medical University, Xi'an, Shaanxi 710032, P.R. China Cancer Research Center, Beijing Chest Hospital, Capital Medical University/Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149, P.R. China Department of Pathophysiology, Key Laboratory of Neurological Diseases of Chinese Ministry of Education, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030. P. R. China Key Laboratory of Data Engineering and Visual Computing, Chongqing University of Posts and Telecommunications , Chongqing 400065 , China; School of Informatics, Aristotle University of Thessaloniki , 54124 Thessaloniki , Greece 1Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, U.S.A. Guangzhou No. 12 Hospital, Guangzhou, China Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, China and Beijing Municipal Key Laboratory of Clinical Epidemiology, Beijing, China Neuropharmacology SectionLaboratory of Pharmacology and ChemistryNational Institute of Environmental Health SciencesNational Institutes of Health Research Triangle Park North Carolina 27709 USA Institute of Biodiversity and Ecology, Zhengzhou University, Zhengzhou 450001, China. Department of Urology, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, Hebei, China Departments of Traditional Chinese Medical Orthopedics, Affiliated Hospital of Shandong Academy of Medical Sciences, Ji’nan, Shandong 250031, P.R. China Centre for Systems Chemistry, Stratingh Institute, Nijenborgh 4, 9747 AG Groningen, The Netherlands Standard Treatment Department of Medical Oncology, Sichuan Cancer Hospital and Institute, Sichuan Cancer Center Medicine School of University of Electronic Science and Technology Chengdu China College of Biology, Hunan University, Changsha, 410082, PR China Lishui People’s Hospital, The Sixth Affiliated Hospital of Wenzhou Medical University, The First Affiliated Hospital of Lishui University, Lishui, China Mitsubishi Chemical Center for Advanced Materials, Department of Materials, Institute for Polymers and Organic Solids, University of California, Santa Barbara, California 93106 Department of Cardiology, The Second Hospital of Jilin University, Changchun, Jilin, China State Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry, the Chinese Academy of Sciences, Shanghai 200031, China. From the Department of Epidemiology (J.W., J.T., C.Z., X.N.), Tianjin Neurological Institute; the Department of Neurology (J.W., L.Y., J.T., C.Z., X.N.), Tianjin Medical University General Hospital; the Departments of Neurology (Z.A.) and Ultrasound (B.L.), Tianjin Huanhu Hospital; the Department of Neurology (B.L., H.G.), Tianjin Dagang Oilfield General Hospital; the Department of Neuro-Immunology (L.Y.), Tianjin Neurological Institute; and the Department of Internal Medicine and Cardiovascular... Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore 117585, Singapore; Institute of Materials Research and Engineering, 3 Research Link, Singapore 117602, Singapore Comprehensive Training Center for Clinical Skills, General Hospital of Ningxia Medical University, Yinchuan 750004, China. The Key Laboratory of Molecular Biology, State Administration of Traditional Chinese Medicine, School of Traditional Chinese Medicine, Southern Medical University, Guangdong, Guangzhou 510515, China School of Chemical Engineering and Technology Tianjin University Collaborative Innovation Center of Chemical Science and Engineering (Tianjin) Tianjin 300072 China Department of Chemical and Biomolecular Engineering; National University of Singapore; Singapore 117585; Institute of Materials Research and Engineering; Agency for Science Department of Pharmacognosy, Logistics University of Chinese People's Armed Police Forces, Tianjin 300309, P.R. China Department of Chemical and Biomolecular Engineering National University of Singapore 4 Engineering Drive 4 Singapore 117585 Singapore School of Biomedical Engineering and Informatics, Nanjing Medical University, Nanjing 211166, China Center for Medical Device Evaluation, Center for Medical Device Evaluation NMPA Beijing China Key Laboratory of High Magnetic Field and Ion Beam Physical Biology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, Anhui 230031, People’s Republic of China; University of Science and Technology of China, Hefei, Anhui 230026, People’s Republic of China Beijing Chest Hospital, Beijing, China Department of Chemical and Biomolecular Engineering National University of Singapore 117576 Singapore; Institute of Materials Research Engineering 3 Research Link 117602 Singapore Department of Otolaryngology-Head and Neck Surgery; Wayne State University School of Medicine; Detroit; USA Department of Respiratory Medicine, the First Affiliated Hospital of Harbin Medical University, China Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore 117576, Singapore Department of Neurosurgery, Dongguan People’s Hospital, Affiliated Dongguan People’s Hospital of Southern Medical University, Dongguan, Guangdong Province, China Neuropharmacology Section, National Institute of Environmental Health Science, National Institutes of Health, Research Triangle Park, NC, USA. Bio‐Innovation Research Center Tokushima University Tokushima Japan; Faculty of Bioscience and Bioindustry Tokushima University Tokushima Japan Jilin Province Product Quality Supervision and Inspection Institute, No.2699 Yiju Road, Changchun 130103, China School of Energy and Power Engineering & School of Material Science and Engineering, North University of China, Taiyuan 030051, P. R. China Department of Orthopaedics, the First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, PR China Department of Chemical and Biomolecular Engineering National University of Singapore 4 Engineering Drive 4 Singapore 117585; Institute of Materials Research and Engineering 2 Fusionopolis Way, Innovis, #08‐03 Singapore 138634 Institute of Applied Microbiology, Guangxi University, Nanning, PR China Aab Cardiovascular Research Institute, University of Rochester, Rochester, USA Department of Otorhinolaryngology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China; Key Laboratory of Organ Transplantation, Ministry of Education, National Health Commission, Chinese Academy of Medical Sciences, Wuhan, Hubei 430030, China Department of Pharmacy, TaiHe Hospital, Hubei University of Medicine, Shiyan, China. College of PharmacyUniversity of Florida Gainesville Florida 32610 the Second Affiliated Hospital of Guang Zhou Medical University, Guangzhou 510260, China. Department of Cardiology, Taiyuan Central Hospital of Shanxi Medical University, Taiyuan, Shanxi 030009, China The University of Texas MD Anderson Cancer Center, Smithville, Texas, United States Authors' Affiliations: Departments of 1Anesthesia and 2Neurological Surgery, and 3UCSF Helen Diller Family Comprehensive Cancer Center, University of California at San Francisco, San Francisco, California; Authors' Affiliations: Departments of 1Anesthesia and 2Neurological Surgery, and 3UCSF Helen Diller Family Comprehensive Cancer Center, University of California at San Francisco, San Francisco, California; Authors' Affiliations: Departments of 1Anesthesia and 2Neurological Surgery, and 3UCSF Helen Diller Family Comprehensive Cancer Center, University of California at San Francisco, San Francisco, California Institute of Oceanology; Chinese Academy of Sciences; Qingdao China School of Computer Science and Technology, Beijing Institute of Technology , Beijing 100081, China; Advanced Research Institute of Multidisciplinary Science, Beijing Institute of Technology , Beijing 100081, China College of Biology, Hunan University, Changsha, Hunan 410082, China College of Food Science Fujian Agriculture and Forestry University Fuzhou P.R. China; National Engineering Research Center of JUNCAO Technology Fujian Agriculture and Forestry University Fuzhou P.R. China Department of Civil, Construction and Environmental Engineering, North Carolina State University, Campus Box 7908, Raleigh, North Carolina 27695-7908, United States State Key Laboratory of Military Stomatology Laboratory Animal Center, School of Stomatology, Fourth Military Medical University Xi'an P.R. China College of Material, Chemistry and Chemical Engineering Hangzhou Normal University Hangzhou 310036 PR China From the State Key Laboratory of Experimental Hematology and National Research Center for Stem Cell Engineering and Technology, Institute of Hematology and Hospital of Blood Diseases, Chinese Academy of Medical Sciences and Peking Union of Medical College, Tianjin, China; and Union Stem Cells Gene Engineering, Tianjin, China. Key Laboratory of Superlight Materials and Surface Technology, Ministry of Education, College of Materials Science and Chemical Engineering, Harbin Engineering University, Harbin 150001, P. R. China Department of General Surgery, The Second Affiliated Hospital of Chengdu Medical College, China National Nuclear Corporation 416 Hospital, Chengdu, Sichuan, 610051, China Department of Interventional Medicine The Second Hospital of Shandong University Jinan China; Interventional Oncology Institute of Shandong University Jinan China Department of Chemical and Biomolecular Engineering, 4 Engineering Drive 4, National University of Singapore, Singapore 117576; Institute of Materials Research Engineering, 3 Research Link, Singapore 117602 Center of Super‐Diamond and Advanced Films (COSDAF) and Department of Materials Science and Engineering City University of Hong Kong Tat Chee Avenue Kowloon Hong Kong China; State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical Technology Beijing 100029 China Nuclear Medicine, Hubei Key Laboratory of Embryonic Stem Cell Research, School of Basic Medical Sciences, Hubei University of Medicine, Shiyan, Hubei, China National Key Laboratory of Science and Technology on Tunable Laser, Harbin Institute of Technology, Harbin 150080, China; Weldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana 47907, United States 1Cancer Center, University of Illinois at Chicago, Chicago, Illinois. Guangdong Provincial Key Laboratory of Optical Information Materials and Technology & Institute of Electronic Paper Displays, South China Academy of Advanced Optoelectronics, South China Normal University, Guangzhou 510006, P. R. China Beijing Aerospace Systems Engineering Research Institute, Beijing 100076, China Department of Pharmacology College of Basic Medicine Binzhou Medical University Yantai China; Institute for Metabolic and Neuropsychiatric Disorders Binzhou Medical University Hospital Binzhou China School of Chinese Materia Medica Beijing University of Chinese Medicine Beijing P. R. China Department of Chemical and Biomolecular Engineering; National University of Singapore; Singapore; Institute of Materials Research and Engineering; Agency for Science Sun Yat-sen University Department of Infectious Diseases, Kunming General Hospital of Chengdu Military Area, Kunming 650223, China. Department of Materials Science and Engineering Southern University of Science and Technology (SUSTech) No. 1088, Xueyuan Road Shenzhen Guangdong 518055 China; School of Advanced Materials Peking University Shenzhen Graduate School Peking University Shenzhen 518055 China Liver Transplantation Division, Department of Surgery, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China. Department of Hand and Foot Surgery The First Hospital of Jilin University 1 Xinmin Street Changchun 130065 P. R. China Department of Chemical and Biomolecular Engineering; National University of Singapore; Singapore 117585; Singapore Immunology Network (SIgN); A*STAR (Agency for Science, Technology and Research) Department of Chemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong Key Laboratory of Superlight Materials and Surface Technology, Ministry of Education, College of Materials Science and Chemical Engineering, Harbin Engineering University, Harbin, 150001, P. R. China Department of Spine SurgeryThe Third Affiliated HospitalSun Yat-sen UniversityGuangzhouChina Department of Vegetable Science College of Agronomy and Biotechnology China Agricultural University Beijing 100193 China; Key Laboratory of Growth and Developmental Regulation for Protected Vegetable Crops of Beijing China Agricultural University Beijing 100193 China Department of Genetics, Department of Chemistry, Key Lab. of Bioorganic Phosphorus Chemistry & Chemical Biology, Tsinghua University, Beijing 100084, P. R. China College of Bioengineering, Henan University of Technology, Lianhua Street, Zhengzhou 450001, China State Key Laboratory of Silicate Materials for Architectures, Wuhan University of Technology, Wuhan 430070, China; Shenzhen Research Institute of Wuhan University of Technology, Shenzhen 518000, China Departments of Chemistry and Materials, Institute for Polymers and Organic Solids, University of California, Santa Barbara, California 93106 ABLINK Biotech Co., Ltd, Chengdu, China 610093 Department of Anesthesiology, Sichuan University West China Hospital Department of Pharmacology, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, 23 Hongda Street, Tianjin 300457, PR China; TEDA Institute of Biological Sciences and Biotechnology, Nankai University, 23 Hongda Street, Tianjin 300457, PR China School of Economics and Management Southwest Petroleum University, Chengdu, China; School of Administration, Chengdu University of Traditional Chinese Medicine, Chengdu, China School of Information Science and Engineering, Shenyang University of Technology, Shenyang 110870, China Wuhan National High Magnetic Field Center & School of Physics, Huazhong University of Science and Technology, Wuhan 430074, China Bio-Innovation Research Center, Tokushima University, Tokushima, Japan; Faculty of Bioscience and Bioindustry, Tokushima University, Tokushima, Japan Guangdong Engineering Technology Research Center for Photoelectric Sensing Materials & Devices Guangzhou Key Laboratory of Sensing Materials & Devices Center for Advanced Analytical Science School of Chemistry and Chemical Engineering Guangzhou University Guangzhou 510006 P. R. China; Department of Materials Science and Engineering Southern University of Science and Technology Shenzhen 518055 P. R. China Contribution from the Mitsubishi Chemical Center for Advanced Materials, Department of Materials, Institute for Polymers and Organic Solids, University of California, Santa Barbara, California 93106 TEDA School of Biological Sciences and Biotechnology, Nankai University, TEDA, Tianjin, People's Republic of China; The Key Laboratory of Molecular Microbiology and Technology of the Ministry of Education, College of Life Sciences, Nankai University, Tianjin, People's Republic of China Department of Entomology Nanjing Agricultural University Nanjing China The Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, Nankai University, Tianjin 300071, China; TEDA Institute of Biological Sciences and Biotechnology, Tianjin Key Laboratory of Microbial Functional Genomics, Nankai University, Tianjin 300457, China Faculty of Bioscience and Bioindustry Tokushima University Tokushima Japan; Laboratory of Animal Reproduction, Bio‐Innovation Research Center Tokushima University Tokushima Japan National Key Laboratory for Electronic Measurement Technology, North University of China, Taiyuan, Shannxi, China School of Engineering, Brown University, Providence, RI 02912; and Department of General Surgery, Huashan Hospital, Fudan University Shanghai 200040, China. TEDA School of Biological Sciences and Biotechnology, Nankai University, 23 Hongda Street, Tianjin 300457, People's Republic of China; Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, 23 Hongda Street, Tianjin 300457, People's Republic of China Shaanxi Key Laboratory of Physico-Inorganic Chemistry, Department of Chemistry, Northwest University, Xi’an 710069, People's Republic of China Institute for Advanced Study, Shenzhen University, Shenzhen, China; Institute for Innovative Development of Food Industry, Shenzhen University, Shenzhen, China Department of Anesthesiology, Huashan Hospital, Fudan University, Shanghai, People’s Republic of China 200040 State Key Laboratory of Heavy Oil Processing, College of Chemistry & Chemical Engineering, China University of Petroleum (East China), Qingdao 266580, P. R. China Department of Obstetrics and Gynecology, The Sixth Medical Center, Chinese PLA General Hospital, Beijing, China; Department of Obstetrics and Gynecology, Chinese PLA General Hospital, Beijing, China The Second Hospital of Jilin University, Changchun 130041, P. R. China Department of Chemistry, Colorado State University Key Laboratory of Metallurgical Equipment and Control Technology, Key Laboratory of Mechanical Transmission and Manufacturing Engineering, Wuhan University of Science and Technology, Wuhan 430081, China First Affiliated Hospital of Anhui Medical University, Department of Radiology, Hefei 230022, China College of Biology, Hunan Province Key Laboratory of Plant Functional Genomics and Developmental Regulation Hunan University Changsha Hunan China School of Energy and Power Engineering, North University of China, Taiyuan 030051, P. R. China Department of Pharmacology, School of Pharmaceutical Sciences, Central South University, No. 110 Xiang-Ya Road, Changsha 410078, P.R. China. School of Pharmacy, Shanxi Medical University, Taiyuan, Shanxi 030001, China Respiratory and Critical Care Medicine of Tianjin Chest Hospital, Tianjin 300222, P.R. China Institute of Crop Sciences, Chinese Academy of Agricultural Sciences, Beijing 10081, China. Department of Engineering Mechanics School of Aerospace Engineering Tsinghua University Beijing 100084 China School of Chinese Pharmacology, Beijing University of Traditional Chinese Medicine, Beijing 100102, China. liubinyn67@163.com Department of Oral Biology, Fourth Military Medical University, Xi'an, Shaanxi, China.; Department of Laboratory Animal Center, Fourth Military Medical University, Xi'an, Shaanxi, China. Department of Nutrition and Health China Agricultural University Beijing 100091 P. R. China; Key Laboratory of Precision Nutrition and Food Quality Research Center of Food Colloids and Delivery of Functionality College of Food Science and Nutritional Engineering China Agricultural University Beijing 100083 P. R. China School of Stomatology, Lanzhou University, Lanzhou, PR China Center of Super‐Diamond and Advanced Films (COSDAF) Department of Physics and Materials Science City University of Hong Kong Tat Chee Avenue Kowloon Hong Kong China College of Materials Science and Engineering, Huaqiao University, Key Laboratory of Molecular Designing and Green Conversions (Fujian University), NO. 668 Jimei Avenue, Jimei District, Xiamen 361021, China College of Biology, Hunan University, Changsha, Hunan, China Guangdong Key Laboratory of Nanomedicine, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, PR China Department of Physiology and Cell Biology, The Ohio State University, Columbus, Ohio 43210 Department of Urology, Xiang’an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen 361101, China College of Food Science and Engineering; Northwest A&F University; Yangling Shaanxi 712100 China Orthopaedics Department, Lishui People's Hospital, Lishui 323000, Zhejiang, China. doctorliubin@163.com Department of Neurosurgery, Kyoto University Graduate School of Medicine Kyoto, Japan. Department of Pediatrics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China. School of Light Industry and Food Sciences, South China University of Technology, Guangzhou 510641, China; Institute for Food and Bioresource Engineering, College of Engineering, Peking University, Beijing 100871, China 4Center for Cancer Genetics and Genomics and Department of Genetics, The University of Texas MD Anderson Cancer Center, Houston, Texas. Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry, University of Science and Technology of China, Hefei 230026, China Department of Neurosurgery, Cangzhou Central Hospital, Cangzhou, Hebei, China Changchun Institute of Applied Chemistry Chinese Academy of Sciences Lab Rare Earth Chem Phys CHINA Polymer Processing Research Laboratory, School of Advanced Manufacturing, Nanchang University, Nanchang 330031, China School of Stomatology, Lanzhou University Central Laboratory, Hebei Key Laboratory of Cancer Radiotherapy and Chemotherapy Affiliated Hospital of Hebei University Baoding China Wuxi People’s Hospital Affiliated to Nanjing Medical University, Wuxi 214000, China Department of Environmental Microbiology, Helmholtz Centre for Environmental Research − UFZ, 04318 Leipzig, Germany; KU Leuven, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Laboratory of Molecular Bacteriology, BE-3000 Leuven, Belgium Key Laboratory for Green Chemical Technology of Ministry of Education School of Chemical Engineering and Technology Tianjin University Collaborative Innovation Center of Chemical Science and Engineering (Tianjin) Weijin Road 92 Tianjin 300072 China State Key Laboratory of Silicon Materials; School of Materials Science and Engineering; Zhejiang University; Hangzhou 310027; P. R. China School of Stomatology, Lanzhou University, Lanzhou, Gansu 730000, China The Second Affiliated Hospital of Guilin Medical University, Guilin, China. Shaanxi Key Laboratory for Advanced Energy Devices; Shaanxi Engineering Laboratory for Advanced Energy Technology; Key Laboratory of Macromolecular Science of Shaanxi Province, School of Materials Science and Engineering, Shaanxi Normal University, Xi’an 710119, China Department of Neurosurgery, Tianjin Medical University General Hospital & Laboratory of Neurooncology, Tianjin Neurological Institute, Tianjin 300052, China. Department of Orthopaedics Xijing Hospital The Fourth Military Medical University Xi’an China School of Materials Science and Chemical Engineering, Institute of Mass Spectrometry Ningbo University Ningbo China State Key Laboratory of Coordination Chemistry, Coordination Chemistry Institute, Nanjing University, Nanjing 210093, People's Republic of China Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, People’s Republic of China School of Medicine and Holistic Integrative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Science, Kunming, People’s Republic of China;; University of the Chinese Academy of Sciences, Beijing, People’s Republic of China; State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, 130012 Changchun, China Department of Nuclear Medicine, West China Hospital, Sichuan University , Chengdu , China Beijing Genomics Institute/Center of Genomics and Bioinformatics, Chinese Academy of Sciences, Beijing 101300, China. Department of Physiology, College of Medicine, Qingdao University; Epithelial Cell Biology Research Center, Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong College of Biology, Hunan Province Key Laboratory of Plant Functional Genomics and Developmental Regulation, Hunan University, Changsha, China; Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China.; Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300, China. State Key Laboratory of Metal Matrix Composites, Department of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240, China College of Food Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China; Marine Food Research and Development Center, Fuzhou Ocean Research Institute, Fuzhou 350002, China School of Materials Science and Engineering and Center for Integrated Computational Materials Engineering, International Research Institute for Multidisciplinary Science, Beihang University, Beijing 100191, China School of Life Sciences, Southwest University, Chongqing, China State Key Laboratory of Elemento‐Organic Chemistry, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), College of Chemistry Nankai University Tianjin China Shenzhen Key Laboratory of Polymer Science and Technology College of Materials Science and Engineering Shenzhen University Shenzhen 518060 China Department of Hand and Foot Surgery, The First Hospital of Jilin University; Jilin Province Key Laboratory on Tissue Repair, Reconstruction and Regeneration, Changchun, Jilin, China. Southwest Medical University, China Key Laboratory of Synthetic and Natural Functional Molecule Chemistry (Ministry of Education), Shaanxi Key Laboratory of Physico-Inorganic Chemistry, Department of Chemistry, Northwest University, Xi’an 710069, China Department of Hand and Foot Surgery; the First Hospital of Jilin University; Jilin China Department of Cardiology, Second Hospital of Jilin University, No. 218 Ziqiang Street, Changchun, 130041, China. liubin3333@vip.sina.com. Department of Gastroenterology Tongren Hospital, Capital Medical University 100073 Beijing China Key Laboratory of Synthetic and Natural Functional Molecule Chemistry (Ministry of Education), Department of Chemistry, Northwest University, Xi’an 710069, China School of Life Sciences, Tsinghua-Peking Joint Center for Life Sciences, Beijing Advanced Innovation Center for Structural Biology, Tsinghua University, Beijing, China Department of Chemical and Biomolecular Engineering National University of Singapore 4 Engineering Drive 4 Singapore 117585 Singapore; Institute of Materials Research and Engineering Agency for Science, Technology and Research (A*STAR) 3 Research Link Singapore 117602 Singapore Institute of Micro-Nano Science and Technology, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, Shanghai 200240, P. R. China School of Materials Science and Engineering, Jiangsu University of Science and Technology, Zhenjiang, Jiangsu 212003, China Department of Respiratory and Critical Care Medicine, Tianjin Chest Hospital, Tianjin 300000, P.R. China Guangdong Key Laboratory of New Technology in Rice Breeding Guangzhou 510640 China Department of Pharmacy, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China Department of Laboratory Medicine, The Fifth People’s Hospital of Wuxi Affiliated to Jiangnan University Wuxi China Institute for Innovative Development of Food Industry, Shenzhen University, Shenzhen, China; Shenzhen Key Laboratory of Marine Microbiome Engineering, Institute for Advanced Study, Shenzhen University, Shenzhen, China The Huntsman Cancer Institute, University of Utah Health Sciences Center, Salt Lake, Utah, USA Department of Vascular Surgery, The Second Affiliated Hospital of Shandong First Medical University, Taian 271000, China Department of Chemistry; Zhejiang University; Hangzhou 310027; China Molecular Epidemiological Research Center, Guangzhou No.12 Hospital, Guangzhou 510620, China. Chinese PLA General Hospital, China; Logistics University of CAPF, China First Department of Neurology, North China University of Science and Technology Affiliated Hospital, Tangshan 063000, China Department of Chemical and Biomolecular Engineering National University of Singapore 4 Engineering Drive 4 117585 Singapore Singapore School of Chemical Engineering and Technology Key Laboratory for Green Chemical Technology of Ministry of Education Tianjin University Tianjin 300072 China Department of Chemical and Biomolecular Engineering; National University of Singapore; Singapore; Institute of Materials Research and Engineering; Agency for Science, Technology and Research (A*STAR) Department of Interventional Medicine The Second Hospital of Shandong University Jinan PR China; Interventional Oncology Institute of Shandong University Jinan China College of Plant Protection, Engineering and Technology Centers of Biopesticide in Shaanxi Northwest Agriculture and Forestry University Yangling China School of Chemical Engineering and Technology, Key Laboratory for Green Chemical Technology of Ministry of Education, Tianjin University, Tianjin 300072, China; Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin 300072, China Department of Neurology, Inner Mongolia Autonomous Region People's Hospital, Hohhot, Inner Mongolia, China. Key Laboratory of Terahertz Optoelectronics; Ministry of Education; Beijing Advanced Innovation Center for Imaging Theory and Technology; Beijing Key Laboratory for Terahertz Spectroscopy and Imaging; Beijing Key Laboratory of Metamaterials and Devices Department of General Surgery Shanghai Jiao Tong University School of Medicine Affiliated Ninth People's Hospital Shanghai China State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 PR China Department of Respiratory Medicine, Ren Ji Hospital, School of Medicine Shanghai Jiao Tong University Shanghai China Department of Urology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, P.R. China TEDA Institute of Biological Sciences and Biotechnology, Nankai University, Tianjin, People’s Republic of China; The Institute of Translational Medicine Research, Tianjin Union Medical Center, Nankai University Affiliated Hospital, Nankai University, Tianjin, People’s Republic of China; The Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, Tianjin, People’s Republic of China; Tianjin Key Laboratory of Microbial Functional Genomics, Tianjin, People’s Republic of China Department of Cardiology, Medical School, Tai Shan Medical College, The Fourth People's Hospital of Jinan, Jinan, P.R. China. Institute of Orthopedics, Chinese PLA General Hospital, Beijing, China. Shanghai Key Laboratory of Chemical Biology, School of Pharmacy East China University of Science and Technology Shanghai China; Shanghai Qingpu District Agricultural Technology Extension Service Center Shanghai China The State Engineering Laboratory of AIDS Vaccine, Jilin University; State Key Laboratory of Supramolecular Structure and Material, Jilin University; Jilin Product Quality Supervision Inspection Department of Biochemistry and Molecular Biology Guangdong Medical University Zhanjiang China China-Japan Union Hospital of Jilin University, Jilin University, Changchun 130033, China College of Food Science and Engineering; Gansu Agricultural University; Lanzhou 730070; China; Beijing Advanced Innovation Center for Food Nutrition and Human Health College of Food Science, Fujian Agriculture and Forestry University, Fuzhou, China; Shenzhen Key Laboratory of Marine Microbiome Engineering, Institute for Advanced Study, Shenzhen University, Shenzhen 518060, China; Institute for Innovative Development of Food Industry, Shenzhen University, Shenzhen 518060, China Department of Cardiology, Fourth People's Hospital of Jinan, Jinan 250031, China. Department of Pharmacodynamics College of Pharmacy University of Florida Gainesville FL 32610 USA Department of Otorhinolaryngology, First Affiliated Hospital of China Medical University, Shenyang 110001, China. liubincmu@163.com Department of Otolaryngology, the First Affiliated Hospital of China Medical University, Shenyang, 110001, China. liubincmu@163.com Beijing Institute of Technology School of Computer Science and Technology, , Beijing 100081, China; Beijing Institute of Technology Advanced Research Institute of Multidisciplinary Science, , Beijing, China Zhejiang Province Key Laboratory of Noble Metal Catalytic Materials and Technology, Hangzhou 310011, P. R. China Bin Liu, Zhi-Qiang Wang, Department of Critical Care Medicine, General Hospital of Tianjin Medical University, Tianjin 300052, China. State Key Laboratory of Coordination Chemistry, Coordination Chemistry Institute, Nanjing University, Nanjing 210093, P. R. China, Departamento de Química Inorgánica, Facultad de Ciencias Químicas, Universidad Complutense, Ciudad Universitaria, E28040-Madrid, Spain, State Key Laboratory of Rare Earth Materials and Applications, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, P. R. China, and State Key Laboratory of Inorganic Syntheses and Preparative Chemistry, Jilin... State Key Laboratory of Elemento-Organic Chemistry, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), College of Chemistry, Nankai University, Tianjin 300071, China Department of Respiratory and Critical Care Medicine, Affiliated Hospital of Logistics University of Chinese People's Armed Police Force, Tianjin 300162, P.R. China Department of Immunology and Rheumatology, Qingdao Municipal Hospital, Qingdao 266011, China. binliu72314@163.com Department of Epidemiology, School of Public Health, Zhejiang Chinese Medical University, Hangzhou, China Division of Chemical and Biomolecular Engineering School of Chemical and Biomedical Engineering Nanyang Technological University 62 Nanyang Drive Singapore 637459 Singapore 1Department of Cancer Epidemiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. Department of Otolaryngology, First Hospital, China Medical University, Shenyang 110001, China. liubincmu@163.com Department of Medicine, School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom; Rural Revitalization Institute, Linyi University, Linyi 276000, China Department of Chemistry, Northwest University, Xi’an 710069, People’s Republic of China State Key Laboratory and Institute of Elemento-Organic Chemistry; Nankai University; Tianjin 300071 People's Republic of China National Key Laboratory of Plant Genomics and Center for Plant Gene Research, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100080, China Department of Chemistry, University of Massachusetts , Amherst, MA 01003 , USA; The Center for Bioactive Delivery, Institute for Applied Life Sciences, University of Massachusetts , Amherst, MA 01003 , USA Department of Hepatobiliary Surgery; the 1st Affiliated Hospital of Kunming Medical University; Kunming; China Department of Radiology, Zhongda Hospital, Southeast University, Nanjing 210009, China School of Computer Science and Technology and 2Key Laboratory of Network Oriented Intelligent Computation, Harbin Institute of Technology Shenzhen Graduate School, Shenzhen, Guangdong 518055, China, 3Shanghai Key Laboratory of Intelligent Information Processing, Shanghai 200433, China, 4Gordon Life Science Institute, Belmont, MA 02478, USA, 5School of Computer, Shenyang Aerospace University, Shenyang, Liaoning, China, 6School of Computer Science, Fudan University, Shanghai 200433, China and 7Center of Excellence in Genomic Medicine Research (CEGMR), King Abdulaziz University, Jeddah 21589, Saudi Arabia; School of Computer Science and Technology and 2Key Laboratory of Network Oriented Intelligent Computation, Harbin Institute of Technology Shenzhen Graduate School, Shenzhen, Guangdong 518055, China, 3Shanghai Key Laboratory of Intelligent Information Processing, Shanghai 200433, China, 4Gordon Life Science Institute, Belmont, MA 02478, USA, 5School of Computer, Shenyang Aerospace University, Shenyang, Liaoning, China, 6School of Computer Science, Fudan University, Shanghai 200433, China and 7Center of Excellence in Genomic Medicine Research (CEGMR), King Abdulaziz University, Jeddah 21589, Saudi Arabia; School of Computer Science and Technology and 2Key Laboratory of Network Oriented Intelligent Computation, Harbin Institute of Technology Shenzhen Graduate School, Shenzhen, Guangdong 518055, China, 3Shanghai Key Laboratory of Intelligent Information Processing, Shanghai 200433, China, 4Gordon Life Science Institute, Belmont, MA 02478, USA, 5School of Computer, Shenyang Aerospace University, Shenyang, Liaoning, China, 6School of Computer Science, Fudan University, Shanghai 200433, China and 7Center of Excellence in Genomic Medicine Research (CEGMR), King Abdulaziz University, Jeddah 21589, Saudi Arabia; School of Computer Science and Technology and 2Key Laboratory of Network Oriented Intelligent Computation, Harbin Institute of Technology Shenzhen Graduate School, Shenzhen, Guangdong 518055, China, 3Shanghai Key Laboratory of Intelligent Information Processing, Shanghai 200433, China, 4Gordon Life Science Institute, Belmont, MA 02478, USA, 5School of Computer, Shenyang Aerospace University, Shenyang, Liaoning, China, 6School of Computer Science, Fudan University, Shanghai 200433, China and 7Center of Excellence in Genomic Medicine Research (CEGMR), King Abdulaziz University, Jeddah 21589, Saudi Arabia Department of Rheumatology The Affiliated Hospital of Medical College Qingdao University Qingdao China TEDA School of Biological Sciences and Biotechnology, Nankai University, Tianjin, P. R. China, Tianjin Key Laboratory of Microbial Functional Genomics, Tianjin, P. R. China Research Institute of Engineering Technology, Yunnan University, Kunming, 650091, P.R. China Institute of Neurobiology, Nursing College, Henan University, Kaifeng, Henan 475004, P.R. China Key Laboratory of Superlight Materials and Surface Technology, College of Materials Science and Chemical Engineering, Ministry of Education, Harbin Engineering University, Harbin 150001, P. R. China 4Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, Texas. Huntsman Cancer Institute University of Utah Health Sciences Center Salt Lake City Utah Department of Anesthesiology West China Hospital of Sichuan University Chengdu Sichuan China Department of Epigenetics and Molecular Carcinogenesis Science Park, The University of Texas MD Anderson Cancer Center Smithville Texas School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore 637457, Singapore School of Art and Archaeology, Zhejiang University, Hangzhou 310028, China. Wuhan National Laboratory for Optoelectronics and School of Optical and Electronic Information; Huazhong University of Science and Technology; Wuhan 430074, China; State Key Laboratory for Superlattices and Microstructures, Institute of Semiconductors; Chinese Academy of Sciences 3Department of Anesthesia, University of California at San Francisco, California.; 4UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, California. Institute of Materials Research Engineering (A*STAR) 3 Research Link Singapore 117602; Department of Chemical and Biomolecular Engineering National University of Singapore 4 Engineering Drive 4 Singapore 117585 Guangdong Provincial Key Laboratory of Sensor Technology and Biomedical Instrument, School of Biomedical Engineering, Sun Yat-Sen University, No. 135, Xingang Xi Road, Guangzhou 510275, P. R. China Center for Phononics and Thermal Energy Science School of Physics Science and Engineering Tongji University Shanghai 200092 P. R. China Center of Super‐Diamond and Advanced Films (COSDAF) & Department of Materials Science and Engineering City University of Hong Kong Tat Chee Avenue Kowloon Hong Kong China Contribution from the Institute for Polymers and Organic Solids, Departments of Materials and Chemistry & Biochemistry, University of California at Santa Barbara, Santa Barbara, California 93106 Department of Cardiology, the Second Hospital of Jilin University , Changchun, Jilin , China Departments of Nuclear Medicine (B.L., R.T., W.P., R.H., A.K.), Chengdu 610041, China Department of Chemical and Biomolecular Engineering; National University of Singapore; Singapore 117576; Singapore; Institute of Materials Research and Engineering School of Chemical and Biomedical Engineering, Nanyang Technological University, 62 Nanyang Drive, 637459, Singapore State Key Laboratory of Metal Matrix Composites; Shanghai Jiao Tong University; Shanghai; China Department of Radiology, First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China School of Energy and Power Engineering North University of China 030051 Taiyuan P. R. China; School of Chemical Engineering and Technology North University of China 030051 Taiyuan P. R. China Department of Orthopaedics, Fuyang People's Hospital, Anhui Medical University, Fuyang, China Division of Hematology-Oncology, Department of Medicine, 11-934 Factor Building, 10833 Le Conte Avenue, University of California, Los Angeles, Los Angeles, CA 90095, USA. Department of Endocrinology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China; Department of Endocrinology, Neijiang First People's Hospital, Chongqing, China. College of Stomatology; Lanzhou University; Lanzhou, China Department of Reproductive Medicine; First Affiliated Hospital of Harbin Medical University; People's Republic of China Department of Laboratory Medicine, The Second Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang 421001, China Department of Medical Oncology, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China People's South Road, Section 4, Number 55, Chengdu 610041, Sichuan, China. TEDA Institute of Biological Sciences and Biotechnology, Nankai University, Tianjin Economic-Technological Development Area, Tianjin, People’s Republic of China; Tianjin Research Center for Functional Genomics and Biochip, Tianjin, People’s Republic of China Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, College of Pharmacy, Jiangsu Ocean University, Lianyungang, China Department of Spine Surgery, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou 0086-510630, China Department of Neurology Inner Mongolia People's Hospital No. 20 of Zhaowuda Road Hohhot 010017 Inner Mongolia People’s Republic of China State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China National Pesticide Engineering Research Center (Tianjin), Department of Chemical Biology, State Key Laboratory of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, P. R. China Jiangsu Provincial Key Laboratory of Advanced Photonic and Electronic Materials School of Electronic Science and Engineering Nanjing University Nanjing 210093 P. R. China; Nanjing National Laboratory of Microstructures Nanjing University Nanjing 210093 P. R. China Department of Orthopedics and Spinal Surgery, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China. johnliu2001@sina.com Cardiovascular Research Center Shantou University Medical College Shantou China; Guangdong Provincial Key Laboratory of Infectious Diseases and Molecular Immunopathology Shantou University Medical College Shantou China Department of Chemical and Biomolecular Engineering, National University of Singapore, Singapore 117576, Division of Hematology–Oncology, Department of Medicine, and Department of Biological Chemistry, University of California, Los Angeles, CA 90095 Department of Digital Media Technology School of Software, Dalian University of Technology Dalian 116620 Liaoning Province China Zhejiang University Department of Horticulture, College of Agriculture and Biotechnology, , Hangzhou 310058, China CAS Key Laboratory of Colloid Interface and Chemical Thermodynamics CAS Research/Education Center for Excellence in Molecular Sciences Institute of Chemistry Chinese Academy of Sciences Beijing 100190 China; School of Chemical Sciences University of Chinese Academy of Sciences Beijing 100049 China Department of Reproduction, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China Department of Anesthesiology, Beijing Tiantan Hospital, Capital Medical University Cell Death and Metabolism Unit; Center for Autophagy, Recycling and Disease; Danish Cancer Society Research Center; Copenhagen, Denmark State Key Laboratory of Elemento-organic Chemistry, Research Institute of Elemento-organic Chemistry, and Department of Biology, College of Life Sciences, Nankai University, Tianjin 300071, China Key Laboratory of Dental Maxillofacial Reconstruction and Biological Intelligence Manufacturing, Gansu Province School of Stomatology, Lanzhou University, Lanzhou 730000, China Department of Chemical and Biomolecular Engineering National University of Singapore Singapore 117585 Singapore; Institute of Materials Research and Engineering Agency for Science Technology and Research (A*STAR) Singapore 117602 Singapore Department of Materials Science and Engineering and The Shenzhen Key Laboratory for Printed Organic Electronics Southern University of Science and Technology No. 1088, Xueyuan Road Shenzhen Guangdong 518055 China Department of Chemistry, Peking University, Beijing, 100871, China, and Institute of Materials Research and Engineering, National University of Singapore, 117602, Singapore Department of Plastic Surgery, Xi’an Central Hospital, Xi’an, Shaanxi, P.R. China Wuhan National Laboratory for Optoelectronics and College of Optoelectronic Science and Engineering, Huazhong University of Science and Technology, Wuhan 430074, China *Texas Children’s Cancer Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030; Department of Hepatobiliary Surgery, Central Hospital of China National Petroleum Corporation, Langfang, Hebei 065000, P.R. China Laboratory of Molecular Cell Biology, The Rockefeller University, 1230 York Avenue, New York, NY 10021; Division of Hematology-Oncology, Department of Medicine, University of California, Los Angeles, CA 90095; and Department of Biochemistry and Molecular Biology, University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030 Departments of Chemistry and Discovery Biology, Chugai Pharma USA, LLC., 6225 Nancy Ridge Drive, San Diego, California 92121, and Metabolic Modulator Research Ltd. (MMRL), 2020 Research Transition Facility, University of Alberta, Edmonton, Alberta, Canada Department of Anesthesiology West China Hospital of Sichuan University Chengdu China School of Material Science and Engineering, University of Jinan, Jinan, China250022 Department of Materials Science and Engineering Southern University of Science and Technology (SUSTech) Shenzhen Guangdong 518055 China Department of Respiratory and Critical Medicine, Tianjin Chest Hospital, Tianjin, China Department of Respiratory and Critical Care Medicine, Characteristic Medical Center of Chinese People's Armed Police Force, Tianjin 300162, China Department of Urology The First Hospital of Jilin University Changchun China Department of Spine Surgery the Third Affiliated Hospital of Sun Yat‐sen University Guangzhou PR China; Guangdong Provincial Center for Quality Control of Minimally Invasive Spine Surgery Guangzhou PR China; Guangdong Provincial Center for Engineering and Technology Research of Minimally Invasive Spine Surgery Guangzhou PR China Department of Obstetrics and Gynecology Dalian Municipal Central Hospital Affiliated to Dalian Medical University Dalian China State Key Lab of Precision Measurement Technology and Instruments, Tianjin University, Tianjin 300072, China. lbin8357@gmail.cn Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore 117576; Institute of Materials Research and Engineering, 3 Research Link, Singapore 117602 Department of Materials Science and Engineering and The Shenzhen Key Laboratory for Printed Organic Electronics Southern University of Science and Technology (SUSTech) No. 1088, Xueyuan Road Shenzhen Guangdong 518055 China Department of Pulmonary Critical Care Medicine, The First Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China Key Laboratory of Functional Inorganic Material Chemistry, Ministry of Education of the People’s Republic of China, School of Chemistry and Materials Science, Heilongjiang University, Harbin 150080, China School of Pharmaceutical Sciences Liaoning University Shenyang 110036 China Tianjin Key Laboratory of Food Biotechnology, College of Biotechnology and Food Science, Tianjin University of Commerce, China School ofStomatology, Lanzhou University, Lanzhou 730000, China. Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese Ministry of Health and Chinese Academy of Medical Sciences The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Qilu Hospital of Shandong University Jinan China School of Computer Science and Technology, Beijing Institute of Technology Beijing China; Advanced Research Institute of Multidisciplinary Science, Beijing Institute of Technology Beijing China Department of Radiology, Zhongda Hospital of Southeast University, Nanjing 210009, China. Department of Interventional Therapy, The Second Hospital of Shandong University, Jinan 250033, China. School of Chemical and Biomedical Engineering Nanyang Technological University 62 Nanyang Drive Singapore 637459 Singapore; Division of Chemistry and Biological Chemistry School of Physical and Mathematical Sciences Nanyang Technological University 21 Nanyang Link Singapore 637371 Singapore US Army Institute of Surgical Research, 3698 Chambers Pass, Fort Sam Houston, TX Department of Bone and Soft Tissue Neurosurgery, Affiliated Tumor Hospital of Guangxi Medical University, Nanning, Guangxi 530021, P.R. China Department of Chemical & Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore, 117576, Singapore. Department of Epigenetics and Molecular Carcinogenesis, University of Texas MD Anderson Cancer Center, Houston, TX 77030 Department of Otorhinolaryngology Head and Neck Surgery, Hunan Provincial People’s Hospital, Changsha 410005, China State Key Laboratory of Ophthalmology Zhongshan Ophthalmic Center Sun Yat‐sen University Guangzhou China Aab Cardiovascular Research Institute and Department of Medicine, University of Rochester, Rochester, New York, USA Department of Anesthesia, UCSF Helen Diller Family Comprehensive Cancer Center, 1001 Potrero Ave., 1305, San Francisco, CA, 94110, USA. bin.liu@ucsf.edu. Contribution from the Institute for Polymers and Organic Solids, Departments of Chemistry and Materials, University of California, Santa Barbara, California 93106 International School of Information Science & Engineering (DUT-RUISE), Dalian University of Technology Dalian, China; DUT-RU Co-Research Center of Advanced ICT for Active Life, Dalian University of Technology Lianoing, China Department of Urology Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050000, Hebei, P.R. China Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, 20032 Shanghai, People’s Republic of China;; Hubei Key Laboratory for Kidney Disease Pathogenesis and Intervention, Hubei Polytechnic University School of Medicine, 435003 Huangshi, Hubei, People’s Republic of China; Department of Chemistry and Key Laboratory for, Preparation and Application of Ordered Structural Materials of, Guangdong Province Shantou University Guangdong 515063 P.R. China; Department of Physics Fudan University Shanghai 200433 P.R. China Department of Pharmaceutical Chemistry, College of Pharmacy, Rutgers, the State University of New Jersey, 160 Frelinghuysen Road, Piscataway, New Jersey 08854-8020 Network and Computing Center, Huazhong University of Science and Technology, Wuhan 430000, China Department of Cardiology, The Second Hospital of Jilin University, 218 Ziqiang Road, Changchun, 130041, China Department of Pharmacy, Liaoning University, Shenyang 110036, China North China Electric Power University 2 School of Nuclear Science and Engineering, , Beijing 102206, People's Republic of China State Key Laboratory of Pollution Control and Resource Reuse, School of Environment, Nanjing University, Nanjing 210023, China Department of Pulmonary Tumor Ward, Sichuan Cancer Hospital, Chengdu 610041, China. Department of Radiology, Zhong-Da Hospital, Southeast University, 87 Dingjiaqiao Rd., Nanjing 210009, China. Guangdong-Hong Kong-Macao Joint Laboratory for Intelligent Micro-Nano Optoelectronic Technology, Foshan University, Foshan 528000, China Division of Hematology-Oncology, Department of Medicine From the State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China; and the College of Information Science and Engineering, Shenyang University of Technology, Shenyang 110870, China 1Division of Pulmonary and Critical Care, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California. Division of Hematology–Oncology, Department of Medicine, Department of General Surgery Shaanxi Provincial People’s Hospital Xi’an China Hubei Key Laboratory for Kidney Disease Pathogenesis and Intervention, Huangshi Central Hospital of Edong Healthcare Group, Hubei Polytechnic University School of Medicine, Huangshi, Hubei 435003, PR China College of Chemistry, Fuzhou University, Fuzhou, Fujian 350116, China Department of Orthopedics China‐Japan Union Hospital of Jilin University Changchun 130033 China; State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 China Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of the Ministry of Education, Shaanxi Key Laboratory of Physico-Inorganic Chemistry, College of Chemistry & Materials Science, Northwest University, Xi’an 710069, P. R. China Guangdong Key Laboratory of New Technology in Rice Breeding Rice Research Institute Guangdong Academy of Agricultural Sciences Guangzhou 510640 China Department of Orthopedics and Microsurgery, Zhengzhou People's Hospital, Zhengzhou 450003, Henan Province, China. Department of Respiratory Medicine, The First Affiliated Hospital of Hainan Medical University, Haikou 570100, China; Hainan Province Clinical Medical Center of Respiratory Disease, Haikou 579199, China; NHC Key Laboratory of Tropical Disease Control, Hainan Medical University, Haikou 571199, China 1Institute of Applied Microbiology, College of Agriculture, Guangxi University, Nanning, PR China Institute of Applied Microbiology, College of Agriculture, Guangxi University, Nanning 530005, China State Key Laboratory of Membrane Biology and Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Institute of Molecular Medicine and Peking-Tsinghua Center for Life Sciences and PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing 100871, China 1 Department of Materials Science and Engineering Southern University of Science and Technology (SUSTech) No. 1088, Xueyuan Road Shenzhen 518055 Guangdong China Department of Dermatology, Xijing Hospital, The Fourth Military Medical University, Xi’an, Shaanxi, China College of Biology, Hunan Province Key Laboratory of Plant Functional Genomics & Developmental Regulation, Hunan University, Changsha, 410082, PR China Anhui University The Forth Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, China. roseliubin@163.com Division of Pulmonary and Critical Care, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095-1690, USA Department of Orthopedics, Xijing Hospital, The Fourth Military Medical University, Xi’an 710032, P. R. China Sichuan University, West China Hospital, Chengdu, Sichuan, China. benbinliu@hotmail.com Department of Neurosurgery Second Affiliated Hospital of Shantou University Medical College Shantou China Department of Chemistry, Capital Normal University, Beijing 100048, China College of Forestry, Northwest A&F University, Yangling, Shaanxi, China Department of Cardiology, the Second Hospital of Jilin University, Changchun, Jilin, People’s Republic of China (B.L.) Department of Hepatobiliary Surgery, General Hospital of Ningxia Medical University, Yinchuan, Ning Xia, China Center for Advanced Mechanics and Materials, Applied Mechanics Laboratory, Department of Engineering Mechanics, Tsinghua University, Beijing 100084, China AML CNMM Department of Engineering Mechanics Tsinghua University Beijing 100084 China Department of Rheumatology, The Affiliated Hospital of Qingdao University Medical College, Shangdong, China. Institute for Innovative Development of Food Industry, Shenzhen University, Shenzhen, Guangdong 518060, People’s Republic of China; Shenzhen Key Laboratory of Marine Microbiome Engineering, Institute for Advanced Study, Shenzhen University, Shenzhen, Guangdong 518060, People’s Republic of China Department of Chemical and Biomolecular Engineering National University of Singapore 4 Science Drive 4 Singapore 117585 Singapore From the Key Laboratory of Cardiovascular Remodeling and Function Research (B.D., C.Z., J.B.F., Y.X.Z., S.Y.L., Y.P.Y., Q.L.D., B.P.D., L.Z., Q.T.Y., C.X.L., B.L., M.X.Z., Y.Z.), Chinese Ministry of Education and Chinese Ministry of Health, Shandong University Qilu Hospital, Jinan, Shandong, P.R. China; the Department of Cardiology (B.D), Shandong Provincial Hospital, Shandong University, Jinan, Shandong, P.R. China; Center of Molecular Medicine (C.M.P., H.D.S.), Shanghai Institute of Endocrinology,... Department of Radiology, the Fourth Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China; Department of Radiology, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China Department of Medical Oncology, Sichuan Cancer Hospital, Chengdu, Sichuan 610041, P.R. China 2Department of Genetics, The University of Texas MD Anderson Cancer Center, Houston, Texas. Department of Reproductive Medicine, First Affiliated Hospital of Harbin Medical University, Harbin, People's Republic of China Contribution from the Department of Chemistry, Washington University, St. Louis, Missouri 63130 Department of Chemical and Environmental Engineering, Faculty of Engineering, National University of Singapore, 10 Kent Ridge Crescent, Singapore 119260 TEDA School of Biological Sciences and Biotechnology, Nankai University, TEDA, Tianjin, People's Republic of China Centre for Molecular Systems and Organic Devices (CMSOD), Key Laboratory for Organic Electronics and Information Displays & Jiangsu Key Laboratory for Biosensors, Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing University of Posts & Telecommunications, 9 Wenyuan Road, Nanjing 210023, China Key Laboratory of Photochemical Conversion and Optoelectronic Materials Technical Institute of Physics and Chemistry The Chinese Academy of Sciences Beijing 100190 P. R. China Clinical Research Standardized Treatment Ward, Department of Medical Oncology, Sichuan Cancer Hospital and Institute, Chengdu, Sichuan 610041, P.R. China Henan Key Laboratory for Helicobacter pylori & Microbiota and GI cancer, Marshall Medical Research Center The Fifth Affiliated Hospital of Zhengzhou University Zhengzhou Henan China; Department of Gastroenterology The Fifth Affiliated Hospital of Zhengzhou University Zhengzhou Henan China Department of Spine Surgery, the Third Affiliated Hospital of Sun Yat-sen University,Guangzhou Guangdong, P.R.China. johnliu@sina.com. Department of Materials Science and Engineering and International Institute of Nanotechnology, Northwestern University, Evanston, Illinois 60208, United States Department of Epidemiology School of Public Health Zhejiang Chinese Medical University Hangzhou China General Surgery, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, PR China; Institute of Digestive Diseases, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, PR China Department of Hand and Foot Surgery, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China 1Department of Anesthesia,; 4Helen Diller Family Comprehensive Cancer Center, University of California at San Francisco, San Francisco, California College of Materials Science and Engineering; Huaqiao University; Xiamen 361021; China; Key Laboratory of Molecular Designing and Green Conversions (Huaqiao University) School of Chemical and Civil Engineering, Shaoguan University, Shaoguan 512023, China School of Computer Science and Technology, Harbin Institute of Technology Shenzhen Graduate School, Shenzhen, Guangdong, China; Gordon Life Science Institute, Belmont, MA, USA Department of Chemistry, Capital Normal University, Beijing, 100048, P. R. China Department of Dermatovenerology, Guangzhou New Century Vitiligo Prevention and Control Research Institute, Guangzhou, China Departments of Neurosurgery and Hubei Collaborative Innovation Center for Advanced Chemical Materials Ministry of Education Key Laboratory for the Synthesis Application of Organic Functional Molecules College of Chemistry and Chemical Engineering Hubei University Wuhan 430062 P.R. China College of Life Science and Technology, Longdong University, Qingyang 745000, China. liubin102102@yahoo.com.cn Department of Chemistry, Zhejiang University, Xixi Campus, Hangzhou 310028, P. R. China, and School of Chemistry and Chemical Engineering, Liaocheng University, Liaocheng 252059, P. R. China School of Computer Science and Technology, Harbin Institute of Technology, Shenzhen, China, and School of Computer Science and Technology, Beijing Institute of Technology, Beijing, China 1 School of Computer Science and Technology and 2Key Laboratory of Network Oriented Intelligent Computation, Harbin Institute of Technology Shenzhen Graduate School, Shenzhen, Guangdong 518055, China, 3Gordon Life Science Institute, Belmont, MA 02478, USA and 4Center of Excellence in Genomic Medicine Research (CEGMR), King Abdulaziz University, Jeddah, 21589, Saudi Arabia; 1 School of Computer Science and Technology and 2Key Laboratory of Network Oriented Intelligent Computation, Harbin Institute of Technology Shenzhen Graduate School, Shenzhen, Guangdong 518055, China, 3Gordon Life Science Institute, Belmont, MA 02478, USA and 4Center of Excellence in Genomic Medicine Research (CEGMR), King Abdulaziz University, Jeddah, 21589, Saudi Arabia; 1 School of Computer Science and Technology and 2Key Laboratory of Network Oriented Intelligent Computation, Harbin Institute of Technology Shenzhen Graduate School, Shenzhen, Guangdong 518055, China, 3Gordon Life Science Institute, Belmont, MA 02478, USA and 4Center of Excellence in Genomic Medicine Research (CEGMR), King Abdulaziz University, Jeddah, 21589, Saudi Arabia Department of Respiratory Medicine Hannover Medical School Hannover Germany; Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH) Member of the German Center for Lung Research (DZL) Hannover Germany The Institute for Chemical Carcinogenesis The State Key Lab of Respiratory Disease, Guangzhou Medical University Guangzhou P.R. China Department of Neurosurgery, Second Affiliated Hospital of Shantou University Medical College, Shantou, China; Department of Chemical and Biomoelcular Engineering National University of Singapore 117576 Singapore Neurology Department, Minhang Hospital, Fudan University, Shanghai, China State Key Laboratory of Biochemical Engineering, Institute of Process Engineering Chinese Academy of Sciences Beijing P. R. China; College of Food Science and Engineering Qilu University of Technology Jinan P. R. China Department of Chemistry; Shenzhen Grubbs Institute and Guangdong Provincial Key Laboratory of Energy Materials for Electric Power; Southern University of Science and Technology (SUSTech); Shenzhen; P. R. China The Sixth Affiliated Hospital of Wenzhou Medical University; Lishui Zhejiang P. R. China Hami-Melon Research Center, Xinjiang Academy of Agricultural Sciences, Urumqi 830091, China Department of Neurology The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital Jinan China; Department of Neurology, Shandong Provincial Qianfoshan Hospital Cheeloo College of Medicine, Shandong University Jinan China; Shandong Institute of Neuroimmunology Jinan China State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry & Chemical Engineering, Institute of Biological Technology, Hunan University, Changsha 410082, P. R. China Department of Anesthesiology, West China Hospital of Sichuan University, Chengdu, Sichuan, China Department of Surgery, Universitätsklinikum Erlangen, Friedrich-Alexander Universität Erlangen, Erlangen, Germany. Guangzhou Institute of Cardiovascular Disease, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou 510260, China First Department of Neurology, Hospital Affiliated to North China University of Science and Technology, Tangshan, China Department of Urinary Surgery, The fourth hospital of Hebei medical university, P. R. China. The Second Hospital, Jilin University, Jilin, China; School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 102488, PR China Department of Nephrology, the Affiliated Hospital of Luzhou Medical College, Luzhou 646000, Sichuan, China. Key Laboratory of Superlight Materials and Surface Technology, Ministry of Education, College of Material Sciences and Chemical Engineering, Harbin Engineering University, Harbin 150001, P. R. China; College of Sciences, Harbin Engineering University, Harbin 150001, P. R. China Department of Respiratory Medicine Renji Hospital Shanghai Jiao Tong University School of Medicine Shanghai China School of Computer Science and Technology, Beijing Institute of Technology, Beijing 100081, China; Advanced Research Institute of Multidisciplinary Science, Beijing Institute of Technology, Beijing, China Key Laboratory of Theoretical Chemistry and Molecular Simulation of Ministry of Education and Hunan Province, College Key Laboratory of QSAR/QSPR School of Chemistry and Chemical Engineering, Hunan University of Science and TechnologyXiangtan Hunan 411201 China Department of Materials Science and Engineering, The Shenzhen Key Laboratory for Printed Organic Electronics, Southern University of Science and Technology (SUSTech), No. 1088, Xueyuan Road, Shenzhen 518055, Guangdong, China Department of Materials Science and Engineering Southern University of Science and Technology (SUSTech) 518055 Shenzhen Guangdong China Department of Spine Surgery, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai 519000, Guangdong, China School of Chinese Materia Medica, Beijing University of TCM, Beijing 100102. Chongqing Key Laboratory of Children Urogenital Development and Tissue Engineering, Chongqing, China;; Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, China; Department of Urology, China-Japan Union Hospital of Jilin University, Changchun 130033, China; State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China Center for Medical Device Evaluation, National Medical Products Administration , Beijing 100081, P.R China Department of Radiation Medicine, Faculty of Naval Medicine, Second Military Medical University, Shanghai, China School of Pharmaceutical Sciences, Nanchang University Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China. Department of General Surgery, General Hospital of Tianjin Medical University, Tianjin 300052, China. liubin78@163.com Jilin Vocational College of Industry and Technology, Jilin, People's Republic of China. State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China Key Laboratory of Chemical Biology; Molecular Engineering of Ministry of Education; Institute of Molecular Science; Shanxi University; Taiyuan 030006 School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China Chongqing Key Laboratory of Children Urogenital Development and Tissue Engineering, Chongqing 400014, China; Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing 400014, China; National Clinical Research Center for Child Health and Disorders (Chongqing), Chongqing 400014, China; China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing 400014, China. Department of Spine Surgery The Third Affiliated Hospital Sun Yat‐Sen University Guangzhou 510630 China Key Laboratory of Mesoscopic Chemistry of MOE, College of Chemistry and Chemical Engineering, Center of Modern Analysis, Department of Physics, Nanjing University, Nanjing 210093, China, and Department of Chemistry, Nanjing Normal University, Nanjing 210097, China Molecular Epidemiological Research Center, Guangzhou No. 12 Hospital, Guangzhou Medical University, Guangzhou, China, Department of Chemical and Biomolecular Engineering, 4 Engineering Drive 4, National University of Singapore, Singapore 117576, Singapore School of Materials Science and Engineering, University of Jinan, Jinan, Shandong 250022, China Institute of Crop Sciences Chinese Academy of Agricultural Sciences Beijing 100081 China Cardiovascular Disease Center, The First Hospital of Jilin University, Changchun, Jilin, China (B.L.). Key Laboratory of High Magnetic Field and Ion Beam Physical Biology, Hefei Institutes of Physical Science Chinese Academy of Sciences Hefei People's Republic of China; University of Science and Technology of China Hefei People's Republic of China Department of Urology Surgery, The Fourth Hospital of Hebei Medical University State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun, China Department of Interventional Medicine, the Second Hospital of Shandong University, Jinan, China Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520; Department of Physics, Hong Kong University of Science and Technology, Hong Kong, China TEDA School of Biological Sciences and Biotechnology, Nankai University, Hongda Street, TEDA, Tianjin 300457, People's Republic of China Department of Chemical and Biomolecular Engineering, 4 Engineering Drive 4, National University of Singapore, 117576, Singapore The First School of Clinical Medicine Lanzhou University 730000 Lanzhou Gansu Province China; Key Laboratory of Molecular Diagnostics and Precision Medicine for Surgical Oncology in Gansu Province Gansu Provincial Hospital 730000 Lanzhou Gansu Province China School of Chemical and Biomedical Engineering; Nanyang Technological University; Singapore Department of Anesthesia, UCSF Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA 94143, USA Department of Hand and Foot Surgery, The First Hospital of Jilin University, Changchun, 130021, P. R. China State Key Laboratory and Institute of Elemento-organic Chemistry, Nankai University, Tianjin 300071, China, and Institute of Fine Chemicals, East China University of Science and Technology, Shanghai 200237, China Photonics Initiative, Advanced Science Research Center, City University of New York, New York, New York 10031, United States; Department of Physics, City College of New York, New York, New York 10031, United States School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing, China School/Hospital of Stomatology, Lanzhou University, Lanzhou, Gansu 730000, China Department of Breast Surgery, The Second Hospital of Jilin University, Changchun, Jilin 130041, P.R. China Department of Materials Science and Engineering Southern University of Science and Technology (SUSTech) Shenzhen, Guangdong 518055 China Department of Plant Genomics Centre for Research in Agricultural Genomics (CRAG), CSIC‐IRTA‐UAB‐UB Bellaterra 08193 Spain Department of Neurology, Shanghai Minhang Central Hospital Shanghai, China. Department of Nephrology and Rheumatology Chinese Medicine Hospital of Hainan Province Haikou China Department of Chemistry and Key Laboratory for Preparation and Application of Ordered Structural Materials of Guangdong Province, Shantou University, Shantou, Guangdong 515063, P. R. China Department of Neurosurgery Qinghai Provincial People's Hospital Xining Qinghai China Department of Public Health Sciences, Henry Ford Health System, Detroit, MI 48202, USA The Second Hospital, University of South China, Hengyang 421001, PR China The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia, China Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education; College of Chemistry & Materials Science; Shaanxi Key Laboratory of Physico-Inorganic Chemistry; Northwest University; Xi'an 710069, P. R. China Department of Neurosurgery, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital Jinan 250014, Shandong, China. Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry; University of Science and Technology of China; Hefei 230026; China Hormel Institute, University of Minnesota , Austin, Minnesota, USA Guangdong Provincial Key Laboratory of Sensor Technology and Biomedical Instrument, School of Biomedical Engineering, Shenzhen Campus of Sun Yat-Sen University, Shenzhen 518107, P. R. China Department of Cardiology, The Second Hospital of Jilin University, Changchun 130041, P. R. China State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 China Department of Spine Surgery, The Sixth Affiliated Hospital of Wenzhou Medical University, Lishui People’s Hospital, Lishui, China Department of Chemistry University of Massachusetts Amherst MA 01003 USA Department of Physiology, Southern Illinois University School of Medicine, Carbondale, Illinois 62901 Institute of Basic Research in Clinical Medicine Molecular Oncology Laboratory, Department of Orthopaedic Surgery and Rehabilitation Medicine, The University of Chicago Medical Center, Chicago, IL 60637, USA; School of Life Sciences, Southwest University, Chongqing 400715, China Department of Chemistry; Capital Normal University; Beijing; China Department of Chemical and Biomolecular Engineering, 4 Engineering Drive 4, National University of Singapore, 117576, Singapore; Institute of Materials Research and Engineering, 3 Research Link, 117602, Singapore Otorhinolaryngology Department of Renji Hospital, School of Medicine Shanghai Jiaotong University Shanghai China Department of Orthopaedics Zhongshan Hospital of Traditional Chinese Medicine Zhongshan Guangdong P.R. China Institute for Metabolic & Neuropsychiatric Disorders, Binzhou Medical University Hospital, Binzhou, 256603 Shandong, China TEDA School of Biological Sciences and Biotechnology, Nankai University, 23 Hongda Street, TEDA, Tianjin 300457, China; Tianjin Key Laboratory of Microbial Functional Genomics, 23 Hongda Street, TEDA, Tianjin 300457, China; Tianjin Research Center for Functional Genomics and Biochip, 23 Hongda Street, TEDA, Tianjin 300457, China Wenzhou Medical University. Wenzhou 355035, Zhejiang Province, China. E-mail:doctorliubin@163.com. Department of urology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China State Key Laboratory of Polymer Materials Engineering of China; College of Polymer Science and Engineering; Sichuan University; Chengdu 610065; China Key Laboratory of Theoretical Chemistry and Molecular Simulation of Ministry of Education; Hunan Province College Key Laboratory of QSAR/QSPR; School of Chemistry and Chemical Engineering; Hunan University of Science and Technology; Xiangtan Department of Clinical Laboratory, Second Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, China First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China Division of Hematology-Oncology; Department of Medicine; University of California Los Angeles; Los Angeles CA USA 2Institute of Immunology, Second Military Medical University, Shanghai, PR China Department of Chemical and Biomolecular Engineering; 4 Engineering Drive 4; National University of Singapore (NUS); Singapore 117585; Institute of Materials Research and Engineering (A*STAR) College of Food Science Fujian Agriculture and Forestry University Fuzhou 350002 China From the Department of Physiology and Cell Biology (H.-T.H., A.E.B., B.L., P.B.R., S.G.), College of Pharmacy (I.M.B., P.B.R., C.A.C.), and College of Veterinary Medicine (K.S.), The Ohio State University, Columbus; Davis Heart and Lung Research Institute, Columbus, OH (H.-T.H., A.E.B., B.L., I.M.B., P.B.R., C.A.C., S.G.); Department of Medicine, Duke University, Durham, NC (H.-T.H.); Laboratory of Neuromuscular Physiology, I.M. Sechenov Institute of Evolutionary Physiology and Biochemistry,... School of Computer Science and Technology, Beijing Institute of Technology, Beijing, China 1Texas Children's Cancer Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas. School of Chemical and Biomedical Engineering; Nanyang Technological University; Singapore 637459; Singapore Beijing Advanced Innovation Center for Food Nutrition and Human Health; Key Laboratory of Functional Dairy; College of Food Science and Nutritional Engineering; China Agricultural University; Beijing 1 School of Computer Science and Technology, Harbin Institute of Technology Shenzhen Graduate School, Shenzhen, Guangdong 518055, China; 2 Key Laboratory of Network Oriented Intelligent Computation, Harbin Institute of Technology Shenzhen Graduate School, Shenzhen, Guangdong 518055, China; 3 Gordon Life Science Institute, Belmont, MA 02478, USA State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 China; Department of Urology China‐Japan Union Hospital of Jilin University Changchun 130033 China Department of Orthopedics, General Hospital of Northern Theater Command , Shenyang 110016 , Liaoning , China School of Nuclear Science and Technology Lanzhou University Lanzhou Gansu China; School of Stomatology Lanzhou University Lanzhou Gansu China Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of the Ministry of Education; Shaanxi Key Laboratory of Physico-Inorganic Chemistry; College of Chemistry & Materials Science; Northwest University; Xi'an 710069 Department of Orthopaedics, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine University of Science and Technology of China Hefei Anhui Province China From the State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China; the State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian 350002, China; University of Chinese Academy of Sciences, Beijing 100049, China Institute of Neurological Disease, Translational Neuroscience Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology Department of Respiratory and Critical Care Medicine The First Affiliated Hospital of Harbin Medical University Harbin China Department of Pharmacology, Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, College of Pharmacy, Jiangsu Ocean University, Lianyungang Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA Institute of Crop Science, Chinese Academy of Agricultural Sciences, Beijing, People's Republic of China. liubin05@caas.cn. Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, The Chinese Academy of Sciences, Beijing 100190, P.R. China Pen−Tung Sah Institute of Micro−Nano Science and Technology, Xiamen University, Xiamen 361000, People’s Republic of China Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China Department of Medical Oncology, Affiliated Hospital of Shandong Academy of Medical Sciences, Jinan, People's Republic of China Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering Key Laboratory of Green Pesticide and Agricultural Bioengineering Ministry of Education Guizhou University Huaxi District Guiyang 550025 China Department of Gastroenterology, The Second Hospital of Shandong University, Jinan, China Institut für Organische Chemie Universität Würzburg Am Hubland 97074 Würzburg Germany Key Laboratory for Organic Electronics and Information Displays & Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing University of Posts & Telecommunications, 9 Wenyuan Road, Nanjing 210023, China College of Chemistry and Chemical Engineering, Qingdao University, 266071 Qingdao, P. R. China Department of Interventional Medicine; The Second Hospital of Shandong University; Jinan Shandong Province China; Interventional Oncology Institute of Shandong University; Jinan Shandong Province China School of Chemical Engineering and Technology, Xi’an Jiaotong University, Xi’an 710049, People’s Republic of China Department of Orthopedics, the First Affiliated Hospital of University of Science and Technology of China (Anhui Provincial Hospital), Hefei Anhui, 230001, P.R.China. Ministry of Agriculture and Rural Affairs Key Laboratory of Soybean Biology (Beijing) Institute of Crop Sciences, Chinese Academy of Agricultural Sciences Beijing China College of Chemistry and Chemical Engineering; Qingdao University; 266071 Qingdao; P. R. China Department of Geriatric Neurology, First Affiliated Hospital of Kunming Medical University, Kunming, People’s Republic of China; Department of Developmental Biology, China Medical University, Shenyang 110001, China. Collaborative Innovation Center for Advanced Organic Chemical Materials Co-constructed by the Province and Ministry, Ministry of Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules, College of Chemistry and Chemical Engineering, Hubei University, Wuhan 430062, P. R. China School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore 637459, Singapore. Hubei Key Laboratory for Kidney Disease Pathogenesis and Intervention, Huangshi Cental Hospital of Edong Healthcare Group, Hubei Polytechnic University School of Medicine, Huangshi, Hubei, China The Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, Nankai University, Tianjin 300457, China; Tianjin Key Laboratory of Microbial Functional Genomics, TEDA Institute of Biological Sciences and Biotechnology, Nankai University, Tianjin 300457, China Beijing National Laboratory for Molecular Science (BNLMS), CAS Key Laboratory of Colloid, Interface and Chemical Thermodynamics, CAS Research/Education Center for Excellence in Molecular Sciences, and Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China; University of Chinese Academy of Sciences, Beijing 100049, China TEDA Institute of Biological Sciences & Biotechnology, Nankai University, TEDA, Tianjin 300457, PR China; The Key Laboratory of Molecular Microbiology & Technology, Ministry of Education, Tianjin 300071, PR China; Tianjin Key Laboratory of Microbial Functional Genomics, Tianjin 300457, PR China Department of Critical Care Medicine, General Hospital of Tianjin Medical University, Tianjin 300052, China. Corresponding author: Liu Bin, Email: liubin78@163.com. Department of Chemical and Biomolecular Engineering; National University of Singapore; 4 Engineering Drive 4 Singapore 117585; Institute of Materials Research and Engineering; Agency for Science; Technology and Research (A*STAR); 3 Research Link Singapore 117602 University of Science and Technology of China 3 Department of EEIS, , Hefei, Anhui 230027, China School of Mechanical Engineering, Northwestern Polytechnical University, Xi’an 710072, China Department of Thoracic Oncology, State Key Laboratory of Biotherapy/Collaborative Innovation Center of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu, China; Department of Medical Oncology, Sichuan Cancer Hospital &institute & School of Medicine, University of Electronic Science and Technology of China, Chengdu, China Key Laboratory of Theoretical Chemistry and Molecular Simulation of Ministry of Education; Hunan Province College Key Laboratory of QSAR/QSPR; School of Chemistry and Chemical Engineering; Hunan University of Science and Technology; Xiangtan, China Research Institute of Subtropical Forestry, Chinese Academy of Forestry, Hangzhou, 311400, China; Zhejiang Provincial Key Laboratory of Tree Breeding, Hangzhou, Zhejiang 311400, China The Institute of Translational Medicine, Tianjin Union Medical Center of Nankai University, Nankai University, Tianjin 300121, People’s Republic of China; Nankai International Advanced Research Institute, Shenzhen 518045, People’s Republic of China; The Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, Tianjin 300071, People’s Republic of China; TEDA Institute of Biological Sciences and Biotechnology, Nankai University, TEDA, Tianjin 300457, People’s Republic of China; Tianjin Key Laboratory of Microbial Functional Genomics, Tianjin 300457, People’s Republic of China Key Laboratory of Kidney Disease Pathogenesis and Intervention of Hubei Province; College of Medicine; Hubei Polytechnic University; Huangshi, Hubei, People's Republic of China; These authors contributed equally to this work. Department of Neonatology, Jinan University-affiliated Shenzhen Baoan Women's and Children's Hospital, Shenzhen, China First Department of Respiratory Medicine, Zhuzhou Central Hospital, Zhuzhou Hunan 412007, China. Department of Interventional Medicine, The Second Hospital, Cheeloo College of Medicine Shandong University Jinan China; Interventional Research Institute of Shandong University Jinan China Department of Otorhinolaryngology, the First Affiliated Hospital of China Medical University, Shenyang, 110001, China. liubincmu@163.com TEDA School of Biological Sciences and Biotechnology, Nankai University, Tianjin, China Department of Cardiology, The Second Hospital of Jilin University, Changchun, Jilin 130000, China College of Marine Sciences, Shanghai Ocean University, Shanghai 201306, China Laboratory of Animal Reproduction, Bio‐Innovation Research Center Tokushima University Tokushima Japan; Faculty of Bioscience and Bioindustry Tokushima University Tokushima Japan Contribution from the Department of Chemical and Biomolecular Engineering, Faculty of Engineering, National University of Singapore, 10 Kent Ridge Crescent, Singapore 119260 Faculty of Materials Science and Engineering, Kunming University of Science and Technology, Kunming, 650093, PR China Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore 117576; Institute of Materials Research Engineering, 3 Research Link, Singapore 117602 Department of Chemical and Biomolecular Engineering National University of Singapore 4 Engineering Drive 4 Singapore 117585 Singapore; Institute of Materials Research and Engineering 2 Fusionopolis Way Singapore 138634 Singapore Center of Systematic Genomics, Xinjiang Institute of Ecology and Geography, Chinese Academy of Sciences, Urumqi, China Department of Materials Science and Engineering City University of Hong Kong Hong Kong SAR 999077 P. R. China State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics Institute of Atmospheric Physics, Chinese Academy of Sciences Beijing China; University of Chinese Academy of Sciences Beijing China Center for Cancer and Inflammation Research, School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong; School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China Basic Integrative Traditional Chinese & Western Medicine, Jiamusi College, Heilongjiang University of Chinese Medicine, Jiamusi, Heilongjiang People's Republic of China Department of Biomedical Engineering, Shandong Provincial Hospital affiliated to Shandong First Medical University, Shandong, China. College of Materials and Chemical Engineering, China Three Gorges University, Yichang, Hubei 443002, China Guangdong Key Laboratory of New Technology in Rice Breeding, Guangzhou 510640, China;; Rice Research Institute, Guangdong Academy of Agricultural Sciences, Guangzhou 510640, China; Jiangsu Key Laboratory for Eco-Agriculture Biotechnology around Hongze Lake, Huaiyin Normal University, Huai’an, Jiangsu, China Institute of Blood Transfusion, Chinese Academy of Medical Sciences & Peking Union Medical College, Chengdu, China Center for Optical Coherence Tomography and Optical Physics, Department of Orthopedic Surgery, Brigham and Women’s Hospital, 75 Francis Street, Boston, MA 02115, USA; Harvard Medical School, 250 Longwood Avenue, Boston, MA 02115, USA Division of Hematology–Oncology, Department of Medicine, and Departments of Biological Chemistry and Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095 Department of General Surgery School of Medicine Shanghai Tenth People's Hospital Tongji University Shanghai China College of Biology and the Environment, Nanjing Forestry University, Nanjing, China State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 P. R. China State Key Laboratory of Coordination Chemistry, Coordination Chemistry Institute, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, P. R. China, and Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry and Chemical Engineering, Suzhou University, Suzhou 215123, P. R. China Department of Spine Surgery, The Sixth Affiliated Hospital of Wenzhou Medical University, The People's Hospital of LiShui, Zhejiang, 323000, China Department of Chemical and Biomolecular Engineering; National University of Singapore; , Singapore Department of Environmental Microbiology, Helmholtz Centre for Environmental Research–UFZ, Leipzig, Germany Department of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China. Jiangsu Provincial Key Laboratory of Advanced Photonic and Electronic Materials, School of Electronic Science and Engineering, Nanjing National Laboratory of Microstructures, Nanjing University, Nanjing 210093, P. R. China Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, the Graduate School of the Chinese Academy of Sciences, Shanghai, People’s Republic of China Department of Urology The Third Xiangya Hospital of Central South University Changsha China Department of Chemical and Environmental Engineering, School of Engineering and Applied Sciences, Yale University, New Haven, Connecticut 06520, United States; Energy Sciences Institute, Yale West Campus, West Haven, Connecticut 06516, United States Department of Urology, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China International School of Information Science & Engineering (DUT-RUISE), Dalian University of Technology, Dalian 116620, China; DUT-RU Co-Research Center of Advanced ICT for Active Life, Dalian University of Technology, Dalian 116620, China Department of Medical Oncology, Cancer Hospital of China Medical University, Liaoning Cancer Hospital and Institute, Shenyang, Liaoning 110042, P.R. China Key Laboratory of Synthetic and Natural Functional Molecule Chemistry (Ministry of Education), Shaanxi Key Laboratory of Physico-Inorganic Chemistry, College of Chemistry and Materials Science, Northwest University, Xi’an 710127, People’s Republic of China College of Food Science, Fujian Agriculture and Forestry University, Fuzhou, Fujian 350002, P. R. China; National Engineering Research Center of JUNCAO Technology, Fujian Agriculture and Forestry University, Fuzhou, Fujian 350002, P. R. China Department of Pediatrics, The Affiliated Hospital of Southwest Medical University, Luzhou, SC, China Department of Chemistry, Princeton University, Princeton, New Jersey 08655 Key Laboratory of Low‐carbon Green Agriculture, Ministry of Agriculture and Rural Affairs Interdisciplinary Research Center for Agriculture Green Development in Yangtze River Basin, College of Resources and Environment, and Academy of Agricultural Sciences, Southwest University Chongqing China Center for Molecular Systems and Organic Devices (CMSOD), Key Laboratory for Organic Electronics and Information Displays & Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing University of Posts & Telecommunications (NUPT), 9 Wenyuan Road, Nanjing 210023, China Center for Medical Device Evaluation of State Food and Drug Administration Beijing Department of Anesthesiology, West China Hospital, Sichuan University, #37 Guoxue Alley, Wuhou District, Chengdu, Sichuan Province, China Pulmonary Tumor Ward, Sichuan Cancer Hospital, Chengdu, China State Key Laboratory of Membrane Biology and Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Institute of Molecular Medicine and Peking-Tsinghua Center for Life Sciences and PKU-IDG/McGovern Institute for Brain Research, Peking University, 100871 Beijing, China School of Integrated Circuit Science and Engineering, Beihang University, Beijing 100191, China National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China College of Science and Key Laboratory for Ferrous Metallurgy, Resources Utilization of Ministry of Education, Wuhan University of Science and Technology, Wuhan 430081, China Featured Crops Engineering Laboratory of Shandong Province, Crop Research Institute, Shandong Academy of Agricultural Sciences, Jinan 250100, China Key Laboratory for Organic Electronics and Information Displays and Institute of Advanced Materials (IAM) Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM) Nanjing University of Posts and Telecommunications 9 Wenyuan Road Nanjing 210023 China Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. binliu@tjh.tjmu.edu.cn Department of Cardiology, Second Hospital of Jilin University, No. 218 Ziqiang Street, Changchun 130041, China Department of Spine surgery the Third Affiliated Hospital of Sun Yat‐sen University Guangzhou P.R. China Shenzhen Key Laboratory of Marine Microbiome Engineering, Institute for Advanced Study, Shenzhen University, Shenzhen 518060, P. R. China; Institute for Innovative Development of Food Industry, Shenzhen University, Shenzhen 518060, P. R. China School of Science, Westlake Institute for Advanced Study, Westlake University, 18 Shilongshan Road, Hangzhou 310024, P. R. China; Department of Physics, Fudan University, Shanghai 200438, P. R. China; Department of Chemistry and Key Laboratory for Preparation and Application of Ordered Structural Materials of Guangdong Province, Shantou University, 243 University Road, Shantou, Guangdong 515063, P. R. China Key Laboratory of Freshwater Fish Reproduction and Development, Ministry of Education, School of Life Sciences Southwest University Chongqing 400715 China Department of General Surgery, Shanghai Ninth People’s Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China School of Chemistry and Chemical Engineering Jiangsu Normal University, Key Laboratory of Green Synthetic Chemistry for Functional Materials Xuzhou Jiangsu 221116 People's Republic of China Department of Intensive Care Unit, Wuhan Asia Heart Hospital, Wuhan Hunan Province Key Laboratory of Plant Functional Genomics and Developmental RegulationCollege of Biology, Hunan University Changsha China Department of Vascular Surgery, Peking University People's Hospital, Beijing 100044, China. Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education; Shaanxi Key Laboratory of Physico-Inorganic Chemistry; College of Chemistry and Materials Science; Northwest University; Xi'an 710069 School of Computer Science and Technology, Harbin Institute of Technology, Shenzhen, Guangdong 518055, China; School of Computer Science and Technology, Beijing Institute of Technology, Beijing 100081, China; Advanced Research Institute of Multidisciplinary Science, Beijing Institute of Technology, Beijing 100081, China TEDA Institute of Biological Sciences and Biotechnology; Nankai University; Tianjin 300457, P. R. China; Key Laboratory of Molecular Microbiology and Technology; Ministry of Education College of Chemistry and Chemical Engineering; Central South University; Changsha; P. R. China State Key Laboratory of Plant Genomics and National Center for Plant Gene Research, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China (W.Z., W.B., B.L., J.C., X.C., M.L., Z.C.); Department of Agronomy, Yangzhou University, Yangzhou 225009, China (C.Y., H.Y., M.G.); and Graduate School of the Chinese Academy of Sciences, Beijing 100101, China (W.Z. State Key Laboratory of Coordination Chemistry; Chemistry and Biomedicine Innovation Center; Jiangsu Key Laboratory of Advanced Organic Materials; School of Chemistry and Chemical Engineering; Nanjing University Pen-Tung Sah Institute of Micro-Nano Science and Technology, Xiamen University, Xiamen, China Department of Chemical and Biomolecular Engineering National University of Singapore Singapore 117576 Republic of Singapore Department of Pharmacodynamics, University of Florida, Gainesville, FL, USA. Bioagricultural Sciences and Pest Management and Program in Plant Molecular Biology, Colorado State University, Fort Collins, Colorado 80523–1177 (P.M.M., R.M.D, J.E.L.); Plant Pathology, Kansas State University, Manhattan, Kansas 66502–5502 (P.M.M.); Rice Research Institute and Plant Protection Institute, Guangdong Academy of Agricultural Sciences, Guangzhou 510640, People's Republic of China (B Postgraduate Student Jilin Product Quality Supervision Inspection State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan Province Key Laboratory of Plant Functional Genomics and Developmental Regulation, College of Biology, Hunan University, Changsha, Hunan, China School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100102, China Wuhan National Laboratory for Optoelectronics and College of Optoelectronic Science and Engineering, Huazhong University of Science and Technology, Wuhan, China Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Science, Beijing 100700, P. R. China College of Materials Science and Engineering Huaqiao University, Key Laboratory of Molecular Designing and Green Conversions (Fujian University) Xiamen China Department of Urology, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, P.R. China Department of Experimental Hematology and Biochemistry, Beijing Key Laboratory for Radiobiology, Beijing Institute of Radiation Medicine, Beijing, China School of Chemical and Biomedical Engineering, Nanyang Technological University, Block N1.2, 62 Nanyang Drive, Singapore 637459, Singapore Department of Pharmacy, Xiangya Hospital, Central South University, Changsha 410008, China. Department of Radiology Department of Cardiology, Friendliness Hospital Yangzhou, Yangzhou, PR China The First Bethune Hospital of Jilin University, Changchun, Jilin, China. Department of Respiratory Medicine, the First Affiliated Hospital of Harbin Medical University, Harbin 150001, China Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore 117585, Singapore.; Joint School of National University of Singapore and Tianjin University International Campus of Tianjin University, Fuzhou 350207, China. Department of Cardiology, Xiangya Hospital, Central South University, Changsha, China Department of Chemical and Biomolecular Engineering National University of Singapore 4 Engineering Drive 4 Singapore 117585 Department of Gastroenterology Cardiovascular Research CenterShantou University Medical CollegeShantouChina Department of Anesthesia, University of California, San Francisco, California 94143, United States; UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, California 94143, United States Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore 117585, Singapore; Institute of Materials Research and Engineering, Agency for Science, Technology and Research (A*STAR), 2 Fusionopolis Way, Innovis, Singapore 138634, Singapore Institute of Nano Biomedicine and Engineering, Shanghai Engineering Research Centre for Intelligent Diagnosis and Treatment Instrument, Department of Instrument Science and Engineering, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, P. R. China State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun Jilin 130022 China Institute of Vegetables and Flowers, Chinese Academy of Agricultural Sciences, Beijing, China; Shaanxi Key Laboratory of Degradable Biomedical Materials, Shaanxi R&D Center of Biomaterials and Fermentation Engineering, Biotech & Biomed Research Institute, School of Chemical Engineering, Northwest University, Xi’an, China Department of Orthopedic Surgery, Shandong Wendeng Osteopathic Hospital, Weihai, Shandong, China Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore 117585 Key Laboratory of Superlight Materials and Surface Technology, Ministry of Education, Harbin Engineering University, Harbin 150001, People’s Republic of China Department of General Surgery, Affiliated Hospital of Xuzhou Medical College, Xuzhou 221002, China. liubinxy@hotmail.com 3Department of Biochemistry and Molecular Biology, Institute of Basic Medicine, Hebei Medical University, Shijiazhuang, Hebei, P.R. China Key Laboratory of Entomology and Pest Control Engineering, College of Plant Protection; Southwest University; Chongqing 400716 China State Key Laboratory and Institute of Elemento-organic Chemistry, Nankai University, Tianjin 300071, China Department of Epigenetics and Molecular Carcinogenesis, University of Texas MD Anderson Cancer Center , Houston, TX 77030, USA School of Computer Science and Technology Beijing Institute of Technology Beijing China; Advanced Research Institute of Multidisciplinary Science Beijing Institute of Technology Beijing China International School of Information Science & Engineering, Dalian University of Technology, Dalian 116024, China Shaanxi Key Laboratory for Advanced Energy Devices, Shaanxi Engineering Lab for Advanced Energy Technology, Key Laboratory of Macromolecular Science of Shaanxi Province, School of Materials Science and Engineering, Shaanxi Normal University, Xi’an, 710119, China Office of Academic Research Affiliated Hospital of Hebei University Baoding China Institute of Material Medica, Chinese Academy of Medical Science, Beijing 100050, China. Department of Intervention Medicine, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, People’s Republic of China; Interventional Oncology Institute, Shandong University, Jinan, People’s Republic of China Department of Cancer Epidemiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Beijing China Department of Burns and Plastic Surgery, Xiangtan Central Hospital, Xiangtan Hunan 411100, China. Traumatic Medicine Center, Lishui People’s Hospital, Lishui 315300, China Cardiovascular Research Center, Institute of Crop Sciences, Chinese Academy of Agricultural Sciences, Beijing 100081, China (B.L.) Department of Orthopedic Surgery, The Third Hospital of Hebei Medical University, No. 139 Ziqiang Road, Shijiazhuang, P.R. China; The Second Hospital of Liaocheng Affiliated to Shandong First Medical University, No. 306 Jiankang Road, Linqing, P.R. China. West China Hospital of Sichuan University, Chengdu, Sichuan, China (B.L.). benbinliu@yahoo.com.cn TEDA Institute of Biological Sciences and Biotechnology, Nankai University, TEDA, Tianjin, China; The Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, Tianjin, China Department of Pharmacodynamics, College of Pharmacy, University of Florida, 1345 Center Drive, Box 100487, Gainesville, FL, 32610, USA. liu@cop.ufl.edu. CAS Key Laboratory of Soft Matter Chemistry, Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei, P. R. China 230026 Department of Urology Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, PR China School of Computer Science and Technology, Harbin Institute of Technology, Shenzhen, China Shenzhen Key Laboratory of Food Nutrition and Health, Institute for Advanced Study, Shenzhen University, Shenzhen 518060, China; Institute for Innovative Development of Food Industry, Shenzhen University, Shenzhen 518060, China Department of Materials Science and Engineering City University of Hong Kong Hong Kong SAR 999077 China Department of Urology Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, P. R. China. Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore 117585, Singapore Beijing Fenghuo Wanjia Technology Company Ltd., Beijing, China Department of Medical Oncology, Sichuan Cancer Hospital & Institute, Chengdu 610041, Sichuan Province, China Department of Chemical and Biomolecular Engineering National University of Singapore 4 Science Drive 4 117585 Singapore; Institute of Materials Research and Engineering Agency for Science, Technology and Research (A*STAR) 2 Fusionopolis Way Innovis 138634 Singapore School of Food Science and Technology Jiangnan University Wuxi 214122 People's Republic of China Department of Chemical and Biomolecular Engineering 4 Engineering Drive 4 National University of Singapore 117585 Singapore; Institute of Materials Research and Engineering 3 Research Link 117602 Singapore College of Forestry, Fujian Agriculture and Forestry University, Fuzhou, China;; Key Laboratory of National Forestry and Grassland Administration for Orchid Conservation and Utilization at College of Forestry, Fujian Agriculture and Forestry University, Fuzhou, China; Department of Gastroenterology Xiangya Hospital Central South University Changsha China Department of Radiology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China for the CCC-ACS Investigators Tianjin Key Laboratory of Microbial Functional Genomics, 23 Hongda Street, TEDA, Tianjin 300457, PR China; TEDA School of Biological Sciences and Biotechnology, Nankai University, 23 Hongda Street, TEDA, Tianjin 300457, PR China; The Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, PR China; Tianjin Research Center for Functional Genomics and Biochips, 23 Hongda Street, TEDA, Tianjin 300457, PR China Department of Chemical Engineering and Materials Science, University of Minnesota, 421 Washington Avenue SE, Minneapolis, Minnesota 55455 Hubei Key Laboratory for Kidney Disease Pathogenesis and Intervention Hubei Polytechnic University School of Medicine Huangshi China Department of Radiology, Huashan Hospital, Fudan University, Shanghai, People's Republic of China Key Laboratory of Dental Maxillofacial Reconstruction and Biological Intelligence Manufacturing, School of Stomatology, Lanzhou University, Lanzhou 730030, China Jiamusi College, Heilongjiang University of Chinese Medicine, Jiamusi 154007, P.R. China Department of Urology, Third Xiangya Hospital, Central South University, Changsha 410013, China 25634849@qq.com. Institute for Innovative Development of Food Industry, Shenzhen University, Shenzhen 518060, China; Shenzhen Key Laboratory of Marine Microbiome Engineering, Institute for Advanced Study, Shenzhen University, Shenzhen 518060, China Division of Sports Medicine and Adult Reconstructive Surgery, Department of Orthopedic Surgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School Nanjing University 321 Zhongshan Road Nanjing Jiangsu 210008 P. R. China; State Key Laboratory of Pharmaceutical Biotechnology Nanjing University Nanjing Jiangsu 210093 P. R. China; Jiangsu Key Laboratory of Molecular Medicine Medical School, Nanjing University Nanjing, Jiangsu 210093 China Aab Cardiovascular Research Institute and Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA Department of Obstetrics and Gynecology, The First Affiliated Hospital of Sun Yat-sen University, 58th Zhongshan 2nd Road, Guangzhou 510080, China State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Nr. 122 Luoshi Road, Wuhan 430070, China School of Chemical and Biomedical Engineering; Nanyang Technological University; , Singapore State Key Laboratory of Biomembrane and Membrane Biotechnology and Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Institute of Molecular Medicine and McGovern Institute for Brain Research and Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China; Key Laboratory of Superlight Materials and Surface Technology, Ministry of Education, Harbin Engineering University, Harbin 150001, P. R. China; State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China Department of Radiology, the First Affiliated Hospital of Anhui Medical University, Hefei, China Cell Death and Metabolism, Center for Autophagy, Recycling and Disease, Danish Cancer Society Research Center Copenhagen Denmark Department of Chemical and Biomolecular Engineering, National University of Singapore, Singapore 117585 Department of Orthopedic Surgery, The First Affiliated Hospital of University of Science and Technology of China Department of Hepatobiliary Surgery, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong 524001, P.R. China College of Food Science Fujian Agriculture and Forestry Univ. Fuzhou 350002 Fujian China TEDA School of Biological Sciences and Biotechnology, Nankai University, TEDA, Tianjin, China Key Laboratory for Green Chemical Technology of Ministry of Education, School of Chemical Engineering and Technology, Tianjin University; Collaborative Innovation Center of Chemical Science and Engineering (Tianjin) 1 , Tianjin 300072, People’s Republic of China Department of Chemical and Bimolecular Engineering, National University of Singapore, 117576, Singapore Beijing Genomics Institute, Chinese Academy of Sciences, 100300, Beijing, China Shenzhen Key Laboratory of Marine Microbiome Engineering; Institute for Advanced Study; Shenzhen University; Shenzhen; China State Key Laboratory of Ophthalmology Zhongshan Ophthalmic Center Sun Yat‐Sen University Guangzhou China Key Laboratory of Marine Genetics and Breeding, Ministry of Education, Ocean University of China, Qingdao 266003, China; Yellow Sea Fisheries Research Institute, Qingdao 266003, China Institute of Materials Research and Engineering (A*STAR); , Singapore 117602; Department of Chemical and Biomolecular Engineering; National University of Singapore; Singapore 117576 First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China. Epithelial Cell Biology Research Center, Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong; Department of Physiology, Medical College, Qingdao University Department of Respiratory Medicine, Renji Hospital, School of Medicine, Shanghai Jiaotong University National Key Laboratory of Science and Technology on Tunable Laser, Institute of Opto-Electronics, Harbin Institute of Technology, Harbin, Heilongjiang, China State Key Laboratory of Coordination Chemistry, Coordination Chemistry Institute, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, PRC, and State Key Laboratory of Rare Earth Materials and Applications, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, PRC Skate Key Laboratory of Natural and Biomimetic Drugs; Peking University; Beijing 100191; China Department of Geriatric Neurology First Affiliated Hospital of Kunming Medical University Kunming China; School of Chemical Engineering and Technology, Key Laboratory for Green Chemical Technology of Ministry of Education, Tianjin University, Tianjin 300072, China; Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin 300072, China; Joint School of National University of Singapore and Tianjin University, International Campus of Tianjin University, Binhai New City, Fuzhou 350207, China; Department of Chemical and Environmental Engineering, School of Engineering and Applied Sciences, Yale University, New Haven, CT 06520, USA National Engineering Research Center for Oil & Gas Drilling and Completion Technology, Yangtze University, Wuhan 430100, China; Hubei Key Laboratory of Oil and Gas Drilling and Production Engineering, Yangtze University, Wuhan 430100, China China West Construction Group Co., Ltd. Hunan Branch, Changsha 410082, China Department of Orthopedics, Xijing Hospital, The Fourth Military Medical University, Xi’an, China State Key Laboratory of Functions and Applications of Medicinal Plants and College of Pharmacy, Guizhou Provincial Engineering Technology Research Center for Chemical Drug R&D, Guizhou Medical University, Guiyang 550025, China Center of Super-Diamond and Advanced Films (COSDAF), City University of Hong Kong, Kowloon, Hong Kong SAR 999077, P. R. China; Department of Material Science and Engineering, City University of Hong Kong, Kowloon 999077, Hong Kong SAR, P. R. China Department of Neurosurgery, Qinghai Provincial People’s Hospital, Xining 810007, Qinghai, China |
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