http://rdf.ncbi.nlm.nih.gov/pubchem/author/MD5_c178cfd1cd088a33da21de778e8ab3b7
Outgoing Links
Predicate | Object |
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family-name | Wang Rui Wang |
name | Rui Wang |
given-name | Rui |
organization-name | State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of Technology Wuhan 430070 P. R. China School of Environmental Science and Engineering, Hebei University of Science and Technology, Shijiazhuang, People’s Republic of China Division of Sleep and Circadian Disorders, Brigham and Women’s Hospital, Boston MA; Department of Biostatistics, Harvard TH Chan School of Public Health, Boston, MA Key Laboratory of Computing Power Network and Information Security, Ministry of Education, Shandong Computer Science Center (National Supercomputer Center in Jinan), Qilu University of Technology (Shandong Academy of Sciences), Jinan 250353, China Key Laboratory of Preclinical Study for New Drugs of Gansu Province, Lanzhou University, Lanzhou 730000, People’s Republic of China; Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin 300071, China Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, P.R. China; State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, P.R. China Faculty of Computer Science, Nanjing University of Posts and Telecommunications, Nanjing, China Department of Cardiology First Hospital of Shanxi Medical University Taiyuan Shanxi China Department of Urology, Tianjin Institute of Urology The Second Hospital of Tianjin Medical University Tianjin China The Cancer Center The Fourth Hospital of Hebei Medical University Shijiazhuang China *Department of Microbiology, Immunology and Molecular Genetics, University of Texas School of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229; and Department of Ophthalmology, the Affiliated Southwest Hospital of Third Military Medical University, Chongqing 400038, China. Department of General Surgery Shanghai General Hospital Shanghai Jiao Tong University Shanghai P. R. China; Department of General Surgery School of Medicine Xiang'an Hospital of Xiamen University Xiamen University Xiamen Fujian P. R. China; Organ Transplantation Institute School of Medicine Xiamen University Xiamen Fujian P. R. China School of Economics and Business Administration, Chongqing University, Chongqing, China School of Computer and Communication Engineering, University of Science and Technology Beijing (USTB), Beijing 100083, China; Shunde Graduate School, University of Science and Technology Beijing, Foshan 528300, China Department of Traditional Chinese Medicine, The First Affiliated Hospital, Xi’an Jiaotong University, Jiankang Road #1, Xi’an 710061, Shannxi Province, China Materials Research Institute/Department of Materials Science and Engineering Pennsylvania State University University Park PA 16802 USA Department of Chemistry Research Center for Analytical Sciences College of Sciences Northeastern University Box 332 Shenyang 110819 China Aging Research Center, Department of Neurobiology, Care Sciences and Society (NVS), Karolinska Institutet-Stockholm University, Sweden (X.X., R.W., D.L.V., G.G., E.J.L., M.D., L.F., C.Q.).; The Swedish School of Sport and Health Sciences, GIH, Stockholm, Sweden (R.W.).; Department of Medicine and Wisconsin Alzheimer’s Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison (R.W.). Henan Key Laboratory of Crystalline Molecular Functional Materials Green Catalysis Center, and College of Chemistry Zhengzhou University Zhengzhou 450001 China School of Materials and Environmental Engineering; Chengdu Technological University; Chengdu; China Department of Organic Chemistry, College of Chemistry, Jilin University, Changchun 130021, China School of Flexible Electronics (Future Technologies) & Institute of Advanced Materials, Nanjing Tech University, Nanjing 211816, People’s Republic of China West China School of Nursing, Sichuan University, Chengdu, People’s Republic of China; Department of Neurology, West China Hospital, Sichuan University, Chengdu, People’s Republic of China Department of Endocrinology, The First Hospital of Qinhuangdao, Qinhuangdao, China York University Toronto Ontario Canada Yunnan Grain Industry Group Co., Ltd, Kunming, China Department of Physics, National University of Singapore, 2 Science Drive 3, Singapore 117542 Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Massachusetts; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts Department of Bioengineering, University of California San Diego , 9500 Gilman Drive, La Jolla, 92093 CA , USA Chongqing Three Gorges University Ji luan Academy Nanchang University Nanchang China Division of Nanophotonics; CAS Key Laboratory of Standardization and Measurement for Nanotechnology; CAS Center for Excellence in Nanoscience; National Center for Nanoscience and Technology; Beijing 100190 Department of Medicine, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA Integrative Science Center of Germplasm Creation in Western China (CHONGQING) Science City and Southwest University, Chongqing Key Laboratory of Crop Quality Improvement, College of Agronomy and Biotechnology, Southwest University, Chongqing 400715, China; Engineering Research Center of South Upland Agriculture of Ministry of Education, Academy of Agricultural Sciences, Southwest University, Chongqing 400715, China Laboratory of Theoretical and Computational Chemistry, Institute of Theoretical Chemistry, College of Chemistry, Jilin University, Changchun, 130023, P. R. China Guangxi Key Laboratory for Aquatic Genetic Breeding and Healthy Aquaculture, Guangxi Academy of Fishery Sciences, Nanning, China College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, Jiangsu Province, China, 210095 Oncology Translational Medicine Bristol‐Myers Squibb Lawrenceville New Jersey USA Department of Electrical and Computer Engineering, National University of Singapore, Singapore 117576 Office of Performance Measurement and Evaluation, New York State Office of Mental Health, Albany, New York Department of PhysiologyCollege of Medicine University of Saskatchewan Saskatoon Canada School of Electronics and Information, Northwestern Polytechnical University, 1 Dongxiang Road, Chang’an District, Xi’an, Shaanxi 710129, P. R. China Jilin Province Key Laboratory of Organic Functional Molecular Design & Synthesis; Department of Chemistry; Northeast Normal University; Changchun 130024; China School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, China School of Electronic Science and Engineering, Xiamen University, Xiamen 361005, P. R. China Department of Ophthalmology, Xi'an No.4 Hospital, Xi'an 710004, Shaanxi Province, China. Department of Clinical Laboratory, The Second Hospital of Shandong University, Jinan, 250033, Shandong Province, China Kaifeng Experimental Station of China Agricultural University, Kaifeng 475004, China Department of Biomaterials, School of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou, China. Division of Chemistry; Department of Biochemistry University of Texas Southwestern Medical Center; Dallas; USA; Department of Chemistry Department of Mathematics, Michigan State University, East Lansing, Michigan 48824, USA; State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China State Key Laboratory of Crop Stress Biology for Arid Areas and College of Life Sciences Northwest A&F University Yangling 712100 China Research Institute of Nephrology, Zhengzhou University The First Affiliated Hospital of Zhengzhou University Zhengzhou 450052 P. R. China; Traditional Chinese Medicine Integrated Department of Nephrology The First Affiliated Hospital of Zhengzhou University Zhengzhou 450052 P. R. China; Henan Province Research Center for Kidney Disease Zhengzhou 450052 P. R. China; Key Laboratory of Precision Diagnosis and Treatment for Chronic Kidney Disease in Henan Province Zhengzhou 450052 P. R. China State Key Laboratory of Natural Medicines China Pharmaceutical University No. 24 Tongjia Lane Nanjing 210009 China Department of Stem Cells and Regenerative Medicine, Key Laboratory of Cell Biology, National Health Commission of China, and Key Laboratory of Medical Cell Biology, Ministry of Education of China, China Medical University, Shenyang 110122, China Department of Clinical Laboratory, Qilu Hospital of Shandong University, Jinan, 250012, Shandong Province, China Shaanxi Key Laboratory of Catalysis; School of Chemical & Environment Science; Shaanxi University of Technology; Hanzhong; P. R. China Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Key Laboratory for Endocrine Tumors, Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai, China (mainland) Blood Screening Laboratory Beijing Red Cross Blood Center Beijing People's Republic of China Beijing Institute of Medical Device Testing, Beijing Center for Testing and Research of Medical Biological Protective Equipment, Beijing 101111, China Department of Environmental Science, Zhejiang University, Hangzhou, Zhejiang 310058, China; Zhejiang Provincial Key Laboratory of Organic Pollution Process and Control, Hangzhou 310058, China E-mail: ykywangrui@yahoo.com.cn. School of Chemistry and Materials Science; Nanjing Normal University; Nanjing; P. R. China National Laboratory of Solid State Microstructures School of Physics Collaborative Innovation Center of Advanced Microstructures Nanjing University Nanjing 210093 China The Swedish School of Sport and Health Science, GIH, Stockholm, Sweden; Department of Neurobiology, Division of Clinical Geriatrics, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden; Wisconsin Alzheimer’s Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA Key Laboratory of Cell Proliferation and Differentiation of the Ministry of Education, School of Life Sciences, Peking-Tsinghua Center for Life Sciences, Peking University , Beijing 100871, China Division of Vascular Surgery, The First Affiliated Hospital of Sun Yat‑sen University, Guangzhou, Guangdong 510080, P.R. China Union Laboratory of Asymmetric Synthesis and School of Life Science, Lanzhou University, Lanzhou 730000, China, and Union Laboratory of Asymmetric Synthesis and Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong, China Department of Occupational Health, School of Public Health, Harbin Medical University, Harbin City, Heilongjiang Province, China Key Laboratory of Small Functional Organic Molecule, Ministry of Education and College of Life Science Jiangxi Normal Univ. Nanchang Jiangxi 330022 China College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, China Polar Research Institute of China Translational Medicine Center, Huaihe Hospital of Henan University, Henan University, Kaifeng, Henan 475000, P.R. China Department of Mathematics; Michigan State University; USA Department of Population Medicine, Harvard Pilgrim Health Care Institute and Harvard Medical School, Boston, MA;; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA State Key Laboratory of Atmospheric Boundary Layer Physics and Atmospheric Chemistry, Institute of Atmospheric Physics Chinese Academy of Sciences Beijing P.R. China Cardiovascular and Metabolic Research Unit, Laurentian University, Sudbury, Ontario, Canada; Department of Biology, York University, Toronto, Ontario, Canada Green Catalysis Center College of Chemistry Zhengzhou University Zhengzhou 450001 China Laboratory of Stem Cell and Tissue Engineering, Orthopedic Research Institute, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Keyuan Road 4, Gaopeng Street, Chengdu, Sichuan 610041, China 2Tobacco Company of Enshi, Hubei Province, Enshi, Hubei 445000, PR China Key Laboratory of Cell Proliferation and Regulation Biology, Ministry of Education, Beijing Normal University, Beijing, China Chemistry and Pharmacy Experimental Teaching Center, Guangdong Medical University, Zhanjiang, China. School of Public Health; Shandong University; Jinan Shandong China Molecular Biology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 Lilly China Drug Development and Medical Affairs Centre, Eli Lilly (Suzhou) Pharmaceutical Co., Ltd Shanghai China Jülich Centre for Neutron Science at MLZ Forschungszentrum Jülich GmbH Lichtenbergstrasse 1 85747 Garching Germany Department of Emergency Intensive Care Unit, The First Affiliated Hospital of Hainan Medical University Haikou 570102, Hainan, China. Department of Physiology, Anqing Medical College, Anqing, China Ctrip.com International Ltd, Shanghai, People's Republic of China Pingshan Translational Medicine Center, Shenzhen Bay Laboratory, Shenzhen 518118, P. R. China Department of Chemistry and Applied Biosciences, ETH Honggerberg, CH-8093, Zurich, Switzerland National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, China National Laboratory of Solid State Microstructures & School of Physics, Nanjing University, Nanjing 210093, China State Key Laboratory of Plant Genomics, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China From the Department of Physiology and Department of Pharmacology, University of Saskatchewan, Saskatoon, SK, Canada. State Key Laboratories of Transducer Technology, Shanghai Institute of Technical Physics, Chinese Academy of Sciences, Shanghai 200083, People’s Republic of China; Key Laboratory of Infrared Imaging Materials and Detectors, Shanghai Institute of Technical Physics, Chinese Academy of Sciences, Shanghai 200083, People’s Republic of China; University of Chinese Academy of Sciences, Beijing 100039, People’s Republic of China College of Plant Protection, Key Laboratory of Pesticide Toxicology & Application Technique, Shandong Agricultural University, Tai’an, Shandong 271018, P. R. China Guangdong Provincial Key Lab of Green Chemical Product Technology School of Chemistry and Chemical Engineering South China University of Technology Guangzhou 510640 China State Key Laboratory for Biology of Plant Diseases and Insect Pests, School of Bioengineering Dalian University of Technology Dalian China School of Pharmacy Shanghai University of Traditional Chinese Medicine Shanghai People's Republic of China College of Environmental Science and Technology, Yangzhou University, Yangzhou 225217, China. Institute for Structure and Function and Department of Physics, Chongqing University, Chongqing 400044, China; Department of Physics and Institute for Quantum Science and Engineering, Southern University of Science and Technology, Shenzhen 518055, China Department of Ultrasonography, Jilin Provincial Cancer Hospital, Changchun, China Department of Neurology West China Hospital Sichuan University Chengdu Sichuan China Beijing Key Laboratory for HIV/AIDS Research, Clinical and Research Center for Infectious Diseases, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China Division of Sleep and Circadian Disorders, Department of Medicine, Brigham & Women’s Hospital & Harvard Medical School, Boston MA; Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA College of Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot 010030, China Chinese Academy of Sciences Proteome Research Cente, Shanghai Applied Protein Technology, Shanghai, Shanghai, China Henan Key Laboratory of Crystalline Molecular Functional Materials Henan International Joint Laboratory of Tumor Theranostical Cluster Materials Green Catalysis Center College of Chemistry Zhengzhou University Zhengzhou 450001 China Department of Physics, Chongqing University, Chongqing 401331, P. R. China The Ministry of Education (MOE) Key Laboratory for Standardization of Chinese Medicines and the STACM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica Shanghai University of Traditional Chinese Medicine Shanghai China State Key Laboratory of Fine Chemical; Dalian University of Technology; Dalian; PR China Department of Clinical Pharmacology, Chinese PLA General Hospital, Beijing, China College of Life Sciences, Yangtze University, Jingzhou, Hubei 434025, China College of Biosystems Engineering and Food Science, Zhejiang Key Laboratory for Agro‐Food Processing, Zhejiang Engineering Center for Food Technology and Equipment Zhejiang Univ Hangzhou Zhejiang 310058 P.R. China; Dept. of Pharmacology and Key Lab of Ministry of Education in Fertility Preservation and Maintenance Ningxia Medical Univ. Yinchuan Ningxia 750004 P.R. China Department of Population Medicine, Harvard Medical School/Harvard Pilgrim Health Care Institute, Boston, Massachusetts, USA School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, P. R. China; Key Laboratory of Preclinical Study for New Drugs of Gansu Province, Lanzhou University, Lanzhou 730000, P. R. China Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun, ChinaDepartment of Thoracic Surgery, The First Hospital of Jilin University, Changchun, China School of Pharmaceutical Sciences, Key Laboratory of Chemical Biology, Ministry of Education, Shandong University, Jinan, China Department of Radiology, Beijing Anzhen Hospital, Capital Medical University , Beijing , People’s Republic of China Department of Bionano Technology, Hanayng University, Ansan 426-791, South Korea Key Laboratory of Wide Band Gap Semiconductor Technology, School of Microelectronics, Xidian University, Xi’an 710071, China Department of Clinical Laboratory, Qilu Hospital, Shandong University, Jinan, 250012, Shandong Province, China ‡Department of Microbiology, New York School of Medicine, New York, NY 10016; and College of Marine Science and Environment, Dalian Ocean University , Dalian 116023 , China From the The Second Affiliated Hospital, Institute of Cancer Stem Cell, Dalian Medical University, China (M.L., Q.L., Y.P., M.G., J.P., X.Y., H.Z., Y.C., J.S., L.W., X.Z., R.W., Y.D., Y.Y.) Department of General Surgery, Changle People's Hospital, Changle County, Shandong 262499, P.R. China The Cardiovascular and Metabolic Research Unit, Laurentian University, Sudbury, ON, Canada P3E 2C6 Department of Cardiology, The First Affiliated Hospital of Hebei North University, Zhangjiakou 075000, China State Key Laboratory of Applied Organic Chemistry, and Institute of Biochemistry and Molecular Biology, School of Life Science, Lanzhou University, 222 Tian Shui South Road, Lanzhou, Gansu 730000, China. School of Materials and Energy, University of Electronic Science and Technology of China, Chengdu 610054, China Authors' Affiliation: Cancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China Department of Pediatric Research Institute, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatrics , Chongqing 400014 , China Blood Screening Laboratory, Beijing Red Cross Blood Center, Beijing, China. Chongqing Key Laboratory for Advanced Materials and Technologies of Clean Energy Faculty of Materials & Energy Southwest University Chongqing 400715 P. R. China Department of Surgery, Case Western Reserve University , Cleveland, OH , USA Graduate School of Heilongjiang University of Chinese Medicine, Harbin 150040. Laboratory of Molecular Neuropathology, Jiangsu Key Laboratory of Neuropsychiatric Diseases & Department of Pharmacology, College of Pharmaceutical Sciences, Soochow University, Suzhou, 215123, Jiangsu, China. Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women’s Hospital, Boston, MA, USA Vegetable Research Institute Guangdong Academy of Agricultural Sciences/Guangdong Key Laboratory for New Technology Research of Vegetables Guangzhou China School of Life Science and Technology, MOE Key Laboratory of Developmental Genes and Human Diseases, Southeast University 1 , Nanjing 210096 , China Department of Dermatology Peking University First Hospital, National Clinical Research Center for Skin and Immune Diseases Beijing China Department of Biochemistry and Molecular Biology, College of Life Science & Technology, Heilongjiang Bayi Agricultural University, Daqing, Heilongjiang 163319, China Department of Medical Oncology, Jinling Hospital of PLA Nanjing 210002, Jiangsu, China. Key Laboratory of Industrial Internet of Things and Networked Control, Ministry of Education, Chongqing University of Posts and Telecommunications, Chongqing 400065, P. R. China Department of Physics and Astronomy and ‡Department of Electrical Engineering and Computer Science, Vanderbilt University, Nashville, Tennessee 37235, United States State Key Laboratory of Applied Organic Chemistry, Institute of Biochemistry and Molecular Biology, Key Laboratory of Preclinical Study for New Drugs of Gansu Province, Lanzhou University, Lanzhou, 730000, China, and Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Kowloon, Hong Kong Shanghai Center for Plant Stress Biology, Center for Excellence in Molecular Plant Sciences, Chinese Academy of Sciences , Shanghai 200032, China; University of Chinese Academy of Sciences , Beijing 100049, China Authors' Affiliations: 1Department of Medical Oncology, Jinling Hospital, School of Medicine, Nanjing University; and 2Department of Biochemistry and Molecular Biology, Nanjing Medical University, Nanjing, PR China State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Avenida Wai Long, Taipa, Macau College of Tobacco Science, Henan Agricultural University, Zhengzhou 450002, China. wangrui2999@126.com Division of Pharmaceutics, Hokkaido Pharmaceutical University School of Pharmacy, Sapporo, Japan. Department of Oncology Jingmen No.1 People's Hospital Jingmen China Molecular Pharmacology and Chemistry Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, United States 1Cardiovascular and Metabolic Research Unit, Laurentian University, Ontario, Canada; 3Department of Biology, Laurentian University, Ontario, Canada; 7Department of Biology, York University, Toronto, Ontario, Canada Department of Chemistry Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials State Key Laboratory of Molecular Engineering of Polymers and iChem Fudan University Shanghai 200433 P. R. China School of Materials Science and Engineering; Zhejiang University; Hangzhou; China Department of Microbiology General Hospital of PLA 28 Fuxing Road, Haidian District Beijing China Nursing Section Department of Gastroenterology Sichuan University Chengdu Sichuan Province China; Infusion Nursing I.V. Team Sichuan University Chengdu Sichuan Province China Department of Otolaryngology-Head and Neck Surgery, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University, Taiyuan, Shanxi, 030032, China. Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. School of Life Sciences; Key Laboratory of Preclinical Study for New Drugs of Gansu Province; School of Basic Medical Sciences; Lanzhou University; Lanzhou From the Departments of Physiology (R.W., R.S.), Pharmacology (X.W., L.W.), and Pathology (Q.M.), University of Saskatchewan, Saskatoon, Saskatchewan, Canada; and the Department of Biology (R.W.), Lakehead University, Thunder Bay, Ontario, Canada. Department of Population Medicine, Harvard Medical School and the Harvard Pilgrim Healthcare Institute, Boston, Massachusetts, USA Pingshan Translational Medicine Center Shenzhen Bay Laboratory Shenzhen 518118 China Department of PhysiologyUniversity of Saskatchewan Saskatoon SK Canada S7N 5E5 Department of Obstetrics and Gynaecology, Monash University, Clayton, Victoria, Australia; Robinson Research Institute and Adelaide Medical School, University of Adelaide, Adelaide, Australia School of Materials Science and Engineering, Zhejiang University, Zheda Road No. 38, Hangzhou 310027, China School of Chemistry & Materials Science, Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials, Jiangsu Normal University, Xuzhou 221116, People’s Republic of China School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, P.R. China; Key Laboratory of Preclinical Study for New Drugs of Gansu Province, Lanzhou University, Lanzhou 730000, P. R. China Department of Biology, Lakehead University, Thunder Bay, Canada.; Cardiovascular and Metabolic Research Unit, Laurentian University, Sudbury, Canada. Division of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, State Key Laboratory for Oncogenes and Related Genes, NHC Key Laboratory of Digestive Diseases, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive Disease, China State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan Provincial Key Laboratory of Biomacromolecular Chemical Biology, Hunan University, Changsha, 410082, P. R. China School of Educational Science and Technology, Anshan Normal University, Anshan 114007, China Department of Mechanical and Materials Engineering, Worcester Polytechnic Institute, 100 Institute Road, Worcester, Massachusetts01609, United States Department of Blood Transfusion, Qilu Hospital of Shandong University (Qingdao), Qingdao, China Office of Performance Measurement and Evaluation, New York State Office of Mental Health, Albany (Radigan, Gu, Frimpong, Wang, Huz, Li); New York State Psychiatric Institute and Department of Psychiatry, Columbia University Vagelos College of Physicians and Surgeons, New York (Nossel, Dixon). Department of Obstetrics and Gynaecology; Monash University; Clayton Australia 1Michigan State University Department of Hematology the First Hospital of Jilin University Changchun China New York State Psychiatric Institute, New York (Haselden, Corbeil, Olfson, Wall, Smith); Office of Performance Measurement and Evaluation, New York State Office of Mental Health, Albany (Tang, Radigan, Frimpong, Wang); Department of Psychiatry, Columbia University Vagelos College of Physicians and Surgeons, New York (Olfson, Dixon, Essock, Wall, Smith); New York-Presbyterian Hospital, New York (Dixon, Essock); Department of Psychiatry, University of Rochester Medical Center, Rochester, New York (Lamberti... Technical Institute of Fluorochemistry, Institute of Advanced Synthesis, School of Chemistry and Molecular Engineering, Nanjing Tech University, 30 South Puzhu Road, Nanjing 211816, P. R. China Key Laboratory of Environmental Biotechnology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China Key Laboratory of Biochemistry and Molecular Biology in Universities of Shandong Province Weifang University Weifang China Department of Radiology The First Affiliated Hospital of Anhui Medical University Hefei China; Research Center of Clinical Medical Imaging, Anhui Province Hefei China; Anhui Provincial Institute of Translational Medicine Hefei China Department of Biochemistry and Siebens-Drake Medical Research Institute, Schulich School of Medicine and Dentistry, Western University, London, Ontario N6A 5C1, Canada; Department of Biomedical Sciences, City University of Hong Kong, Kowloon, Hong Kong Special Administrative Region, China CAS Key Laboratory of Coastal Environmental Processes and Ecological Remediation, Research Centre for Coastal Environmental Engineering and Technology, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China Guangdong Provincial Key Laboratory of Atmospheric Environment and Pollution Control, National Engineering Laboratory for VOCs Pollution Control Technology and Equipment, School of Environment and Energy, South China University of Technology, Guangzhou, 510640, China State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, Key Laboratory of Molecular Drug Research and KLMDASR of Tianjin, Nankai University, Tongyan Road, Haihe Education Park, Tianjin 300350, China School of Life Science and Technology, MOE Key Laboratory of Developmental Genes and Human Diseases Southeast University Nanjing China The Centre of Nanoscale Science and Technology and Key Laboratory of Functional Polymer Materials Institute of Polymer Chemistry, College of Chemistry and Renewable Energy Conversion and Storage Center (RECAST) Nankai University Tianjin 300071 China Authors' Affiliations: 1Department of Neurosurgery, Xijing Institute of Clinical Neuroscience, Xijing Hospital and Departments of 2Health Statistics and 3Pathology, Fourth Military Medical University, Xi'an, Shaanxi Province, People's Republic of China Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham & Women’s Hospital, Boston, Massachusetts; Harvard Medical School, Boston, Massachusetts State Key Laboratory of Cancer Biology and Xijing Hospital of Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, Shaanxi Province, PR China Collaborative Innovation Center for Optoelectronic Science and Technology and Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, Shenzhen University, Shenzhen 518060, P. R. China; Department of Electronic Engineering, Xiamen University, Xiamen 361005, P. R. China Institute of Pharmacy, School of Pharmacy, Henan University, Kaifeng, China Department of Biostatistics, Harvard T H Chan School of Public Health, Boston, MA, USA; Department of Medicine, Harvard Medical School, Boston, MA, USA; Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston, MA, USA. Department of Clinical Laboratory The Second Hospital of Shandong University Jinan Shandong China Department of Nursing, Nanjing Medical University Affiliated Healthcare Hospital for Women and Infants, Nanjing, China First Ward of General Surgery Department, Hongqi Hospital Affiliated to Mudanjiang Medical University, Mudanjiang, China National University of Singapore 1 Department of Physics, , 2 Science Drive 3, 117542, Singapore Key Laboratory of Preclinical Study for New Drugs of Gansu Province School of Basic Medical Sciences Lanzhou University 199 West Donggang Road Lanzhou 730000 China; Research Unit of Peptide Science 2019RU066 Chinese Academy of Medical Sciences 199 West Donggang Road Lanzhou 730000 China Affiliated Hospital of Shandong University of TCM, Jinan 250011, China. wr_6510@163.com Key Laboratory of Microelectronics Devices & Integrated Technology; Institute of Microelectronics; Chinese Academy of Sciences; Beijing 100029; P. R. China Department of Gastroenterology, Tianjin Medical University General Hospital, Tianjin 300052, P.R. China College of Chemical and Environment Protection; Southwest Minzu University; Chengdu; China Zhejiang University Department of Chemistry, University at Albany, State University of New York, 1400 Washington Ave., Albany, NY 12222, USA; The RNA Institute, University at Albany, State University of New York, 1400 Washington Ave., Albany, NY 12222, USA Shanghai Key Laboratory of New Drug Design, Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, and State Key Laboratory of Bioengineering Reactor, East China University of Science & Technology, 130 Meilong Road, Shanghai 200237, China Division of Nanomaterials & Chemistry, Hefei National Research Center for Physical Sciences at the Microscale, Department of Chemistry, Institute of Biomimetic Materials & Chemistry, University of Science and Technology of China, Hefei 230026, China Key Laboratory of Colloid and Interface Chemistry, Shandong University, Ministry of Education, Jinan 250100, PR China Department of Gastroenterology, Zaozhuang Hospital of Chinese Medicine, Zaozhuang, Shandong, China Department of Plant Pathology, North Dakota State University, Fargo, ND 58108 North Sichuan Medical College, Nanchong, 637000, China. Department of Epidemiology and Biostatistics, Jilin University School of Public Health, Changchun, China National Laboratory of Solid State Microstructures, School of Physics, and Collaborative Innovation Center of Advanced Microstructures, Nanjing University 1 , Nanjing 210093, China State Key Laboratory of Applied Organic Chemistry and Institute of Biochemistry and Molecular Biology, Lanzhou University, Lanzhou 730000, China, and Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Kowloon, Hong Kong Department of Dermatology Chinese PLA General Hospital & Medical School Beijing China Department of Urology, the First Affiliated Hospital, Zhengzhou University, Henan, Zhenzhou 450052, China. National Key Laboratory of Crop Improvement for Stress Tolerance and Production, College of Life Science Northwest A&F University Yangling 712100 Shaanxi China School of Environment and Energy; South China University of Technology; Guangzhou 510006; China College of Physics Nanjing University of Aeronautics and Astronautics, and Key Laboratory of Aerospace Information Materials and Physics (NUAA) MIIT Nanjing 211106 China State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, Nanjing 211816, China; College of Food Science and Light Industry, Nanjing Tech University, Nanjing 211816, China; The Jiangsu Synergetic Innovation Center for Advanced Bio-Manufacture, Nanjing Tech University, Nanjing 211816, China Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham & Women’s Hospital & Harvard Medical School, Boston, MA, USA Anhui Chest Hospital, Hefei, PR China From the Department of Physiology, University of Saskatchewan, Saskatoon, Canada. College of Chemistry; Jilin University; Changchun 130012; P. R. China Aging Research Center, Karolinska Institutet and Stockholm University, Stockholm, Sweden; The Swedish School of Sport and Health Sciences, GIH, Stockholm, Sweden Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University, Lanzhou, People's Republic of China Center for Bioelectronics and Biosensors, Biodesign Institute and Department of Electrical Engineering, Arizona State University, Tempe, Arizona 85287-5801 Department of Population Medicine Harvard Pilgrim Health Care Institute and Harvard Medical School Boston Massachusetts USA; Department of Biostatistics Harvard T.H. Chan School of Public Health Boston Massachusetts USA Memorial Sloan-Kettering Cancer Center, New York, New York, USA State Key Laboratory of Shale Oil and Gas Enrichment Mechanism and Effective Development, Beijing 102206, China; SINOPEC Key Laboratory of Carbon Capture, Utilization and Storage, Beijing 102206, China; Petroleum Exploration and Development Research Institute, SINOPEC, Beijing 102206, China Hainan Key Laboratory for Sustainable Utilization of Tropical Bioresource, College of Tropical Crops, Hainan University, Haikou 570228, China Shanghai Key Laboratory of Magnetic Resonance, School of Physics and Electronic Science, East China Normal University, Shanghai 200241, China Jiangsu Normal University Department of Nephrology, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing, China (mainland) Department of Biology Laurentian University, Sudbury, Canada. 1 European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SD, UK, Department of Neurobiology, Care Sciences and Society (NVS) Aging Research Center Karolinska Institutet‐Stockholm University Stockholm Sweden Biodesign Center for Bioelectronics and Biosensors Arizona State University Tempe AZ 85287 USA Hangzhou Hospital of Traditional Chinese Medicine Pingshan Translational Medicine Center, Shenzhen Bay Laboratory, Shenzhen 518118, China Key Laboratory of Green Prevention and Control of Tropical Plant Diseases and Pests, Ministry of Education, College of Plant Protection, Hainan University, Haikou, China National Key Laboratory of Continental Shale Oil, Daqing Oilfield of CNPC, Daqing, Heilongjiang 163002, China Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, and. Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts. Section of Hematology/Oncology Department of Medicine The University of Chicago Chicago Illinois USA; State Key Laboratory of Cancer Biology and Xijing Hospital of Digestive Diseases Xijing Hospital Fourth Military Medical University Xi'an China The First Clinical College of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China Authors' Affiliations: 1Massachusetts General Hospital Cancer Center and 2Center for Molecular Therapeutics, Harvard Medical School, Charlestown, Massachusetts; 3Howard Hughes Medical Institute, 4Center for Head and Neck Cancers, 5Department of Pathology, and 6Biostatistics Center, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts; 7Biotheranostics, San Diego, California; and Departments of 8Pathology and 9Medicine, University of Chicago, Chicago, Illinois Beijing Key Laboratory of Ionic Liquids Clean Process CAS Key Laboratory of Green Process and Engineering State Key Laboratory of Multiphase Complex Systems Institute of Process Engineering Chinese Academy of Sciences Beijing 100190 China Department of Thoracic Surgery, Cancer Hospital/Cancer Institute of Fudan University, 270 Dong'an Road, Shanghai 200032, China 1Department of Endocrinology and Metabolism, China National Research Center for Metabolic Diseases, Shanghai, China Shenzhen Agricultural Product Quality and Safety Inspection and Testing Center (Guangdong Provincial Key Laboratory of Supervision and Administration of Edible Agricultural Products, Market Supervision Administration), Shenzhen 518000, China Department of Health Statistics, West China School of Public Health, Sichuan University, Chengdu 610041, China. Department of Physiology, College of Medicine, The Cardiovascular Research Group University of Saskatchewan Saskatoon SK Canada S7N 5E5 Department of Aesthetic, Plastic and Maxillofacial Surgery, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China; Hunan Academy of Forestry; National Engineering Research Center for Oil Tea Camellia Department of Oncology, Suqian People's Hospital of Nanjing Drum Tower Hospital Group, Suqian, Jiangsu 223800, P.R. China State Key Laboratory of Microbial Technology Shandong University, No. 72 Binhai Road Qingdao 266237 China Department of Medical Oncology, The First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233004, P.R. China Department of Physical Chemistry, School of Metallurgical and Ecological Engineering, University of Science and Technology Beijing, Beijing 100083, China Sichuan Global Creatives Corporation Battery Material CO., LTD, Meishan 620000, China Department of Clinical Pharmacology, PLA General Hospital, Beijing, China Department of Neurosurgery, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou 121001, China Office of Performance Measurement and Evaluation, New York State Office of Mental Health, Albany State Key Laboratory of Respiratory Disease, National Clinical Center for Respiratory Diseases, Guangzhou Institute of Respiratory Diseases, First Affiliated Hospital, Guangzhou Medical University, Guangzhou 510120, China. High-Performance Metal Structural Materials Research Institute, Soochow University, Suzhou 215021, China; School of Iron and Steel, Soochow University, Suzhou 215021, China Shanghai Cancer Center and Institutes of Biomedical Sciences Fudan University Shanghai People's Republic of China Tsukuba Life Science Innovation Program (T-LSI), University of Tsukuba, Tsukuba 305-8577, Japan School of Materials Science and Engineering Beihang University No. 37 Xueyuan Road, Haidian District Beijing 100191 P. R. China; Beijing Advanced Innovation Centre for Biomedical Engineering Beihang University No. 37 Xueyuan Road, Haidian District Beijing 100191 P. R. China Key Laboratory of Bioorganic Phosphorous Chemistry and Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing 100084, P. R. China Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry University of Science and Technology of China Hefei Anhui 230026 China College of Chemistry, Beijing Normal University, Beijing 100875, China; Institute of Chemical Engineering and Technology, Xi’an Jiaotong University, Xi’an 710049, China Center of Basic Molecular Sciences (CBMS) Department of Chemistry Tsinghua University Beijing 100084 China Michigan Center for Translational Pathology, University of Michigan, Ann Arbor Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China China General Nuclear New Energy Holdings Co., Ltd, Beijing, 100071, China State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China School of Pharmacy and ‡Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China Department of Biostatistics, Harvard University, T. H. Chan School of Public Health, 677 Huntington Ave, Boston, MA 02115, USA and Department of Population Medicine, Harvard Pilgrim Health Care Institute and Harvard Medical School, 401 Park Drive, Boston, MA 02215, USA Key Laboratory of Hainan Trauma and Disaster Rescue, The First Affiliated Hospital of Hainan Medical University, Hainan Medical University, Haikou 571199, China; Engineering Research Center for Hainan Bio-Smart Materials and Bio-Medical Devices, Key Laboratory of Emergency and Trauma, Ministry of Education, Key Laboratory of Hainan Functional Materials and Molecular Imaging, College of Pharmacy, College of Emergency and Trauma, Hainan Medical University, Haikou 571199, China State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Yuanmingyuan West Road 2, Beijing 100193, China National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases (NITFID), National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and Prevention Beijing China; WHO WPRO Regional Polio Reference Laboratory and National Health Commission Key Laboratory for Biosafety, National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and Prevention Beijing China Department of Hepatobiliary and Pancreatic Surgery, The Center for Integrated Oncology and Precision Medicine, Affiliated Hangzhou First People’s Hospital, Zhejiang University School of Medicine, Hangzhou 310006, China; NHC Key Laboratory of Combined Multi-Organ Transplantation, Hangzhou 310003, China Department of Critical Care Medicine, Qilu Hospital (Qingdao), Cheeloo College of Medicine, Shandong University, Qingdao, China; College of Public Health Zhengzhou University Zhengzhou People's Republic of China School of Ophthalmology & Optometry, Eye Hospital, Wenzhou Medical University, 270 Xueyuan Road, Wenzhou 325027, China Harvard Pilgrim Health Care Institute and Harvard Medical School Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA and Department of Population Medicine, , Boston, MA 02215, USA Changchun Institute of Optics, Fine Mechanics and Physics Shanghai Key Laboratory of Chemical Biology; and State Key Laboratory of Bioengineering Reactor; East China University of Science & Technology; Shanghai 200237; China Department of Physiology, Institute of Basic Medicine Ningxia Medical University Yinchuan China; Department of Pharmacology, College of Pharmacy Ningxia Medical University Yinchuan China Pingshan translational medicine center, Shenzhen Bay Laboratory Shenzhen 518118 P.R. China School of Life Sciences, Northwestern Polytechnical University, Xi’an, China Memorial Sloan Kettering Cancer Center New York New York Center for Infectious Diseases, Beijing You-An Hospital, Capital Medical University, Beijing, China. Laurentian University, Sudbury, ON, Canada P3E 2C6 Department of Chemistry and Applied Biosciences, ETH Zurich, CH-8093, Zurich, Switzerland Ministry of Land and Resources Key Laboratory of Metallogeny and Mineral Assessment, Institute of Mineral Resources, Chinese Academy of Geological Sciences, Beijing 100037, China. State Key Laboratory of Electronic Thin Films and Integrated Devices, School of Optoelectronic Science and Engineering, University of Electronic Science and Technology of China (UESTC), Chengdu 610054, P. R. China Department of Chemistry, Institute of Biomimetic Materials & Chemistry, Anhui Engineering Laboratory of Biomimetic Materials, Division of Nanomaterials & Chemistry, Hefei National Research Center for Physical Sciences at the Microscale, University of Science and Technology of China, Hefei 230026, People’s Republic of China Department of Hepatobiliary Surgery the Second Affiliated Hospital of Chongqing Medical University Chongqing China Zhejiang College of Security Technology, Wenzhou, China Memorial Sloan Kettering Cancer Center, New York, NY, USA MOE Key Laboratory of Aquatic Product Safety/State Key Laboratory for Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, People's Republic of China Food Safety Key Laboratory of Zhejiang Province, School of Food Science and Biotechnology; Zhejiang Gongshang University; Hangzhou 310035 P.R. China State Key Laboratory of Management and Control for Complex Systems, Institute of Automation, Chinese Academy of Sciences, Beijing, China Department of Pathophysiology, School of Basic Medical Sciences, Ningxia Medical University; NHC Key Laboratory of Metabolic Cardiovascular Diseases Research, Ningxia Medical University; Ningxia Key Laboratory of Vascular Injury and Repair Research Chongqing Key Laboratory of Environmental Materials & Remediation Technologies; College of Chemistry and Environmental Engineering; Chongqing University of Arts and Sciences; Yongchuan 402160; China College of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang 150040, China Division of Sleep and Circadian Disorders, Departments of Neurology and Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts; Department of Biostatistics and Department of Cardiovascular Surgery, Nanjing Hospital Affiliated to Nanjing Medical University, Nanjing Cardiovascular Hospital, Nanjing 210006, China. Key Laboratory of Advanced Energy Materials Chemistry (Ministry of Education) Haihe Laboratory of Sustainable Chemical Transformations College of Chemistry Nankai University Tianjin 300071 P. R. China College of Food Science and Engineering Bohai University, National R&D Branch Center of Surimi and Surimi Products Processing Jinzhou P. R. China Department of Clinical Pharmacology, the PLA General Hospital, Beijing 100853, People's Republic of China State Key Laboratory of Materials-Oriented Chemical Engineering; Jiangsu National Synergetic Innovation Center for Advanced Materials; College of Chemical Engineering; Nanjing Tech University; Nanjing 210009 Department of Urology, Tianjin Medical University General Hospital, Tianjin, 300052, China. 18622039735@163.com. Department of Pharmacy, Centre of Medicine Clinical Research, PLA General Hospital, Beijing, China Radiology and Biomedical Imaging Department, Yale University, New Haven, CT, USA Engineering Research Center of Modern Preparation Technology of TCM of Ministry of Education, Shanghai University of Traditional Chinese Medicine, Shanghai, China; Laboratory of Clinical Pharmacology, Chinese People’s Liberation Army General Hospital, Beijing, China grid.258151.a 0000 0001 0708 1323 Key Laboratory of Industrial Biotechnology of Ministry of Education, School of Biotechnology Jiangnan University 214122 Wuxi Jiangsu China; grid.258151.a 0000 0001 0708 1323 School of Pharmaceutical Science Jiangnan University 214122 Wuxi Jiangsu China Department of Medical Oncology, Jinling Hospital, School of Medicine, Nanjing University, Nanjing 210002, China College of Food Science and Light Industry, State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, No. 30 Puzhu South Road, Nanjing 211816, China Liuzhou Worker's Hospital Liuzhou Guangxi China Department of Cardiology, The First Hospital of China Medical University, Shenyang, China Department of Pathology & Pathophysiology, and Cancer Institute of The Second Affiliated Hospital, Zhejiang University School of Medicine Hangzhou, China. Zhejiang University Cancer Center, Key Laboratory of Disease Proteomics of Zhejiang Province, Key Laboratory of Cancer Prevention and Intervention of China National Ministry of Education, Zhejiang University School of Medicine Hangzhou, China. State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Wuhan 430070, P. R. China Department of Physiology, University of Saskatchewan, Saskatoon, SK, Canada S7N 5E5 Department of Pharmacy, the Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250355, Shandong, China. Department of Medical Oncology, Anhui Chest Hospital, Hefei, People's Republic of China. Department of Trauma Intensive Care Unit, First Affiliated Hospital, Xinjiang Medical University, Urumqi 830011, China Division of Cardiology, Department of Internal Medicine Virginia Commonwealth University Richmond Virginia USA State Key Laboratory of Protein and Plant Gene Research and School of Life Sciences Peking University China Fujian Province Neurosurgery Institute, Department of Neurosurgery, The Affiliated Union Hospital, Fujian Medical University, Fuzhou 350001, China. benmedical@sina.com.cn School of Chemistry, Sun Yat-sen University, Guangzhou 510006, China Taizhou Institute of Agricultural Sciences, Jiangsu Academy of Agricultural Sciences, Taizhou 210014, China Department of Pathobiological Sciences, School of Veterinary Medicine Louisiana State University 1909 Skip Bertman Drive Baton Rouge Louisiana 70803 USA Key Laboratory of Polar Materials and Devices (MOE), Department of Electronics, East China Normal University, Shanghai 200241, China Shanghai Clinical Center for Endocrine and Metabolic Diseases, Department of Endocrinology and Metabolism, Shanghai Institute of Endocrine and Metabolic Diseases, China National Research Center for Metabolic Diseases, National Key Laboratory for Medical Genomes, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai, China State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences University of Macau Macau China Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, and Immune Disease Institute and Children's Hospital, Boston, MA 02115 Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Department of Medicine, Brigham and Women’s Hospital, Boston, MA, USA Department of Ophthalmology, Massachusetts Eye and Ear Infirmary/Schepens Eye Research Institute, Harvard Medical School, Boston Massachusetts, United States; Department of Ophthalmology, The First Hospital of Xi'an, Xi'an, Shaanxi, China Department of Pharmacology and Neuroscience, Texas Tech University Health Science Center, Lubbock, TX, USA College of Food Science and Engineering; School of Life and Pharmaceutical Science; Hainan University; Haikou 570228; P. R. China Carnegie Mellon, USA Clinical Laboratory, Shaanxi Provincial Institute for Tuberculosis Control and Prevention, Xi’an 710048, PR China Key Laboratory of Material Chemistry for Energy Conversion and Storage (Huazhong University of Science and Technology) Ministry of Education Hubei Key Laboratory of Material Chemistry and Service Failure School of Chemistry and Chemical Engineering Huazhong University of Science and Technology Wuhan Hubei 430074 P. R. China Department of Surgery, Pudong Branch of Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200126, China Shanghai Synchrotron Radiation Facility, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201204, China Institute of Atomic and Molecular Physics; Jilin University; Changchun 130012; China The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei‐MOST) and Key Laboratory of Oral Biomedicine Ministry of Education School and Hospital of Stomatology Wuhan University Wuhan 430079 P. R. China Department of Population Medicine, Harvard Medical School, Harvard Pilgrim Health Care Institute, Boston, Massachusetts State Key Laboratory of Applied Organic Chemistry, Institute of Biochemistry and Molecular Biology, Lanzhou University, Lanzhou, 730000, China, and Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Kowloon, Hong Kong Research Institute of Clinical Medicine, Urumqi General Hospital of Lanzhou Military Region, Urumqi, Xinjiang 830000, China. wrxj2005@gmail.com Department of Ophthalmology, Hainan Branch of PLA General Hospital, Sanya 572000, Hainan Province, China. Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi 214122, China. Institutes of Physical Science and Information Technology Leibniz Joint Research Center of Materials Sciences of Anhui Province Anhui University Hefei 230601 China Department of Oncology Wayne State University School of Medicine Detroit MI USA; Department of Diagnostics of Chinese Medicine Hebei University of Chinese Medicine Hebei China Institutes of Physical Science and Information Technology Leibniz International Joint Research Center of Materials Sciences of Anhui Province Anhui Province Key Laboratory of Environment‐Friendly Polymer Materials Key Laboratory of Structure and Functional Regulation of Hybrid Material (Ministry of Education) Anhui University Hefei 230601 China Department of Materials Science and Engineering and ‡Department of Chemistry, University of Illinois at Urbana−Champaign, Urbana, Illinois 61801, United States Department of Electronic Engineering; Xiamen University; Xiamen 361005; China; College of Electronic Science and Technology State Key Laboratory of Tree Genetics and Breeding, Northeast Forestry University, Harbin 150040, China; State Key Laboratory of Tree Genetics and Breeding, Key Laboratory of Tree Breeding and Cultivation of National Forestry and Grassland Administration, National Innovation Alliance of Catalpa bungei, Research Institute of Forestry, Chinese Academy of Forestry, Beijing 100091, China Human Phenome Institute, State Key Laboratory of Genetic Engineering, Fudan University, Shanghai 200438, China The Key Laboratory of Trace Element Nutrition MOH; Institute of Nutrition and Food Safety; Chinese Center for Disease Control and Prevention; Beijing 100050; P.R. China National Key Laboratory of Veterinary Public Health Security, Key Laboratory for Prevention and Control of Avian Influenza and Other Major Poultry Diseases and Key Laboratory of Animal Epidemiology of Ministry of Agriculture and Rural Affairs, College of Veterinary Medicine, China Agricultural University Chinese Center for Disease Control and Prevention, Key Laboratory of Trace Elements and Nutrition of National Health Commission, National Institute of Nutrition and Health, Beijing 100032, China Harvard Pilgrim Health Care Institute, Harvard Medical School, Boston, Massachusetts Department of Orthopaedic, Nanjing Municipal Hospital of Traditional Chinese and Western Medicine, Nanjing 210014, Jiangsu, China. wangrui_217@hotmail.com Department of Biochemistry & Molecular Biology, School of Life Sciences, Lanzhou University, Lanzhou 730000, China, and State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China State Key Laboratory of Marine Environmental Science, Institute of Marine Microbes and Ecospheres, Xiamen University, Xiamen, People's Republic of China Key Laboratory of Advanced Energy Materials Chemistry (Ministry of Education) Renewable Energy Conversion and Storage Center College of Chemistry Nankai University Tianjin 300071 P. R. China Key Laboratory for Advanced Materials and Feringa Nobel Prize Scientist Joint Research Center, Frontiers Science Center for Materiobiology and Dynamic Chemistry, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai 200237, China Department of Materials Science and Engineering, University of California, Los Angeles, California 90095, United States Ministry of Natural and Resources Key Laboratory of Metallogeny and Mineral Assessment, Institute of Mineral Resources, Chinese Academy of Geological Sciences, Beijing 100037, China. Brigham and Women's Hospital, Boston, MA; Harvard Medical School, Boston, MA Institute of Atomic and Molecular Physics Jilin University Changchun 130012 China Department of Biostatistics, School of Public Health Peking University Beijing China Laboratory of Molecular Neuropathology, Jiangsu Key Laboratory of Neuropsychiatric Disorders & Department of Pharmacology, College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu 215123, China Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University, Lanzhou, China. Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA; Department of Breast Medicine Services, Memorial Sloan Kettering Cancer Center, New York, New York, USA Garrison Institute on Aging, Texas Tech University Health Sciences Center, Lubbock, Texas, USA School of Urban Construction, Wuhan University of Science and Technology, Wuhan 430065, China Southeast Sichuan Geological Group, Chongqing Bureau of Geology and Minerals Exploration, Chongqing 400038, China. Chongqing Key Laboratory of Land Quality Geological Survey, Chongqing 400038, China. School of Earth Sciences and Resources, China University of Geosciences, Beijing 100083, China. The First Affiliated Hospital of XI’AN Jiaotong University Plastic and Cosmetic Maxillofacial Surgery, Xi’an, Shanxi 710061, China Department of Radiology, China-Japan Union Hospital of Jilin University, Changchun, Jilin 130033, China Department of Biochemistry and Molecular Biology, School of Life Science, Lanzhou University, Lanzhou 730000, China, and Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry, Peking University, Beijing 100871, China Department of Neurosurgery Shanghai East Hospital, School of Medicine, Tongji University Shanghai China Department of Chemistry, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, State Key Laboratory of Molecular Engineering of Polymers and Laboratory of Advanced Materials, Fudan University, Shanghai 200433, People’s Republic of China Collaborative Innovation Centre for Marine Biomass Fibers; Materials and Textiles of Shandong Province; College of Chemical and Environmental Engineering; Qingdao University; Qingdao, P. R. China Wuhu Institute of Technology, Wuhu, PR China Covidien Respiratory & Monitoring Solutions, Edinburgh EH26 0PJ, UK Department of Thoracic Surgery, Hebei Cancer Hospital, Shijiazhuang 050011, China. Flexible Electronics Innovation Institute (FEII), Jiangxi Science and Technology Normal University, Nanchang 330013, PR China Institute of Clinical Medicine, Urumqi General Hospital of Lanzhou Command, PLA, Urumqi, Xinjiang, China. Department of Preventive Medicine, College of Veterinary Medicine Henan Agricultural University Zhengzhou Henan China; International Joint Research Center of National Animal Immunology, College of Veterinary Medicine Henan Agricultural University Zhengzhou Henan China Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, China School of Pharmaceutical Science, Jiangnan University, 1800 Lihu Road, Wuxi, Jiangsu Province 214122, P. R. China Hefei National Laboratory for Physical Sciences at Microscale, and School of Life Sciences, University of Science and Technology of China Hefei Anhui 230026 People's Republic of China Department of Geriatric Respiratory and Critical Care Medicine, The First Affiliated Hospital of Anhui Medical University, Hefei, China Department of Pharmacology and Physiology, Université de Montréal Montréal, QC H3T 1C5, Canada. Institute of Pharmacology, Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic, Medical Sciences, Lanzhou University, Lanzhou 730000, China; State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, Peoples Republic of China; Collaborative Innovation Centre of Chemical Science and Engineering (Tianjin), Tianjin 300071, China Food and Pharmaceutical Engineering Institute Guiyang University Guiyang 550005 China School of Materials Science and Engineering Beihang University No. 37 Xueyuan Road Haidian District Beijing 100191 P. R. China Beijing Key Laboratory of Magnetic Resonance Imaging Technology, Beijing�100191, P.R.�China Chongqing Key Laboratory for Advanced Materials and Technologies of Clean Energy Faculty of Materials & Energy Southwest University Chongqing 400715 P.R. China School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, Henan, China.; China-US (Henan) Hormel Cancer Institute, Zhengzhou, Henan, China. Key Laboratory for Processing and Quality Safety Control of Characteristic Agricultural Products, Ministry of Agriculture and Rural Affairs Shihezi University Shihezi China; College of Food Science and Engineering Tianjin University of Science and Technology Tianjin China College of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225002, P. R. China The Key Laboratory of Synthetic and Biological Colloids Ministry of Education School of Chemical and Material Engineering International Joint Research Laboratory for Nano Energy Composites Jiangnan University Wuxi 214122 P. R. China Department of Blood Transfusion, Qilu Hospital at Qingdao, Shandong University, Qingdao, People’s Republic of China Qilu hospital of Shandong University Dezhou Hospital, Dezhou, 253000, China Shanghai Key Laboratory of New Drug Design, School of Pharmacy East China University of Science and Technology Shanghai 200237 China Department of Radiology Guangzhou Women and Children's Medical Center Guangzhou China Graduate College of Tianjin Medical University Tianjin China Key Laboratory of Preclinical Study for New Drugs of Gansu Province, Institute of Biochemistry and Molecular Biology, and State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, China Key Laboratory of Preclinical Study for New Drugs of Gansu Province School of Basic Medical Sciences Institute of Biochemistry and Molecular Biology State Key Laboratory of Applied Organic Chemistry Lanzhou University Lanzhou China Oncology Discovery, AbbVie, North Chicago, Illinois. School of Public Security, Gansu Institute of Political Science and Law, Lanzhou 730070, China; Institute of Biodiversity, Huangshan University, Huangshan 245041, China; Department of Biochemistry and Molecular Biology, University of Florida, Gainesville, FL 32610, USA; School of Life Sciences, Lanzhou University, Lanzhou 730000, China; Interdisciplinary Center for Biotechnology Research, Univerisity of Florida, Gainesville, FL 32610, USA State Key Laboratory of Atmospheric Boundary Layer Physics and Atmospheric Chemistry Institute of Atmospheric Physics, Chinese Academy of Sciences Beijing China Institute of Functional Materials and Molecular Imaging, Key Laboratory of Emergency and Trauma, Ministry of Education, College of Pharmacy, Key Laboratory of Hainan Trauma and Disaster Rescue, College of Clinical Medicine, College of Emergency and Trauma, Hainan Medical University, Haikou 571199, China Department of Radiology and Biomedical Imaging Yale University New Haven CT USA; Department of Engineering Physics Tsinghua University Beijing China; Key Laboratory of Particle and Radiation Imaging Ministry of Education Tsinghua University Beijing China All authors: Department of Respiratory and Critical Care Medicine, Beijing Chao-Yang Hospital, Beijing Institute of Respiratory Medicine, Beijing Key Laboratory of Respiratory and Pulmonary Circulation Disorders, Capital Medical University, No. 8 Gongren Tiyuchang Nanlu, Chaoyang District, Beijing, China. Harvard Pilgrim Health Care Institute and Harvard Medical School, Boston, Massachusetts, USA; Harvard T. H. Chan School of Public Health, Harvard University, Boston, Massachusetts, USA Department of Thoracic Surgery, Fourth Affiliated Hospital of Hebei Medical University, Shijiazhuang 050011, China. xwkwr@yahoo.com.cn Laboratory of Nutrition and Development, Beijing Pediatric Research Institute, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, China Shanghai Applied Protein Technology Co. Ltd Shanghai 200233 P.R. China School of Chemical & Environment Science; Shaanxi University of Technology; Hanzhong; China Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, People’s Republic of China, and State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, People’s Republic of China School of Chemistry and Chemical Engineering, Shandong University of Technology, 266 West Xincun Road, Zibo 255000, P. R. China School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China. State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing, China; Key Laboratory of Soil Microbiology, Ministry of Agriculture, China Agricultural University, Beijing, China; Rhizobium Research Center, China Agricultural University, Beijing, China Department of Urology and Carson International Cancer Center, Shenzhen University General Hospital and Shenzhen University Clinical Medical Academy Center Shenzhen University Shenzhen People's Republic of China The Second Clinical Medical College, Guangdong Provincial Hospital of Chinese Medicine, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou University of Chinese Medicine , Guangzhou, Guangdong 510120 , PR China; Clinical and Basic Research Team of TCM Prevention and Treatment of NSCLC, Department of Oncology, Guangdong-Hong Kong-Macau Joint Lab on Chinese Medicine and Immune Disease Research , Guangzhou, Guangdong 510120 , PR China; Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome , Guangzhou, Guangdong 510120 , PR China Department of Physics and Astronomy, The University of Kansas, Lawrence, Kansas 66045, United States State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China 1Department of Surgical Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas. Key Laboratory of Emergency and Trauma, Ministry of Education, Key Laboratory of Hainan Trauma and Disaster Rescue, The First Affiliated Hospital of Hainan Medical University, Institute of Functional Materials and Molecular Imaging, College of Pharmacy, College of Emergency and Trauma, Hainan Medical University, Haikou 571199, China Engineering Research Center of Modern Preparation Technology of TCM of Ministry of Education, Shanghai University of Traditional Chinese Medicine, Shanghai, China From the *Department of Radiology, Beijing Anzhen Hospital, Capital Medical University; †Department of Radiology, Beijing Huairou Hospital, Beijing China; and ‡Department of Medical Radiation Sciences, Curtin University, Perth, Western Australia, Australia. Key Laboratory of Food Nutrition and Safety, Ministry of Education, Tianjin University of Science and Technology, Tianjin 300457, China Institute of Applied Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230088, People’s Republic of China; University of Science and Technology of China, Hefei 230026, People’s Republic of China; Key Laboratory of Photovolatic and Energy Conservation Materials, Chinese Academy of Sciences, Hefei 230031, People’s Republic of China Department of Population Medicine, Harvard Medical School/Harvard Pilgrim Health Care Institute, Boston, Massachusetts, USA; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA CAS Key Laboratory of Standardization and Measurement for Nanotechnology; CAS Center for Excellence in Nanoscience; National Center for Nanoscience and Technology; Beijing 100190; China From the Department of Physiology and Pathophysiology (L.J., Xiangxiang Wei, J.L., Xinhong Wang, C.N., X.K., J.X., Z.Z., R.Q., N.S., A.C., R.W., S.C., D.M.) and Department of Biochemistry and Molecular Biology (S.S., Xu Wang), School of Basic Medical Sciences, Fudan University, Shanghai, China; Department of Cardiothoracic Surgery, Shanghai Children’s Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China (M.Y.); Key Laboratory of Nutrition and Metabolism, Institute for... Department of Sanitary Inspection, School of Public Health Shandong University Jinan China Department of Orthopedics, Peking University First Hospital, Beijing 100034, P.R. China State Key Joint Laboratory of Environmental Simulation and Pollution Control, School of Environment, Tsinghua University, Beijing 100084, China Petroleum Exploration and Production Research Institute, Sinopec, Beijing 100083, China Department of Biomedical Sciences; City University of Hong Kong; Kowloon; Hong Kong Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts; Department of Population Medicine, Harvard Pilgrim Health Care Institute and Harvard Medical School, Boston, Massachusetts; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts Department of Dermatology Chinese People's Liberation Army General Hospital Beijing China College of Chemistry, Beijing Normal University, Beijing, 100875, China; Institute of Chemical Engineering and Technology, Xi'an Jiao Tong University, Xi'an, 710049, China Aging Research Center, Department of Neurobiology, Care Sciences and Society Karolinska Institutet and Stockholm University Stockholm Sweden; Wisconsin Alzheimer's Disease Research Center University of Wisconsin School of Medicine and Public Health Madison Wisconsin; The Swedish School of Sport and Health Science GIH Stockholm Sweden MOE of the Key Laboratory of Bioinorganic and Synthetic Chemistry, The Key Lab of Low-Carbon Chem & Energy Conservation of Guangdong Province, School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, P. R. China AbbVie Bioresearch Center, Worcester, MA 01605 Department of Dermatology, First Medical Centre of Chinese PLA General Hospital, Beijing, China Department of Biology, Laurentian University, Sudbury, Canada Zhejiang Engineering Research Center for Tissue Repair Materials, Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou 325000, China Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Institute of Biochemistry and Molecular Biology, School of Life Sciences, Lanzhou University, Lanzhou, People's Republic of China Department of Neurology, The Third Affiliated Hospital of Sun Yat-Sen University, 600 Tianhe Road, Guangzhou, Guangdong 510630, China Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham & Women's Hospital, Boston, MA; Harvard Medical School, Boston, MA Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts.; Division of Sleep Medicine, Brigham and Women's Hospital, Boston, Massachusetts. The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine) , Zhejiang , 310006 , China Key Laboratory of Wide Band Gap Semiconductor Technology School of Microelectronics Xidian University Xi'an 710071 China State Key Laboratory of Applied Organic Chemistry, Institute of Biochemistry and Molecular Biology, Lanzhou University, Lanzhou 730000, China, and State Key Laboratory of Chinese Medicine and Molecular Pharmacology, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Kowloon, Hong Kong, China State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences Fujian Fuzhou 350002 China Key Laboratory for Organic Electronics and Information Displays and Jiangsu Key Laboratory for Biosensors, Institute of Advanced Materials, Jiangsu National Synergetic Innovation Centre for Advanced Materials, Nanjing University of Posts and Telecommunications, Nanjing 210023, P. R. China State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China; Graduate School of Chinese Academy of Sciences, Beijing, China Department of Chemistry Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials State Key Laboratory of Molecular Engineering of Polymers and iChem Fudan University Shanghai 200433 P. R. China Department of Chemistry, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China College of Chemistry and Molecular Sciences; Wuhan University; Wuhan; P. R. China Department of Orthopaedics, Peking University First Hospital, Beijing 100034, China Key Laboratory of Material Chemistry for Energy Conversion and Storage (Huazhong University of Science and Technology), Ministry of Education, Hubei Key Laboratory of Material Chemistry and Service Failure, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan 430074, China National Energy Key Laboratory for New Hydrogen-Ammonia Energy Technologies, Foshan Xianhu Laboratory, Foshan 528200, China; State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Wuhan 430070, China Department of Gastroenterology, The First Affiliated Hospital of Hebei North University, Zhangjiakou, Hebei, China Key Laboratory of Preclinical Study for New Drugs of Gansu Province; School of Basic Medical Sciences; Lanzhou University; Lanzhou; P. R. China The Second Affiliated Hospital Institute of Cancer Stem Cell Dalian Medical University Dalian China State Key Laboratory of Cognitive Neuroscience and Learning and IDG/McGovern Institute for Brain Research, Beijing Normal University , Beijing , China Yangpu District Central Hospital Affiliated to Tongji University School of Medicine Shanghai 200090, China. The First Affiliated Hospital of Xi’an Jiaotong University Department of Obstetrics and Gynaecology, School of Clinical Sciences at Monash Health, Monash University, Melbourne, Victoria, Australia Department of Chemistry Institute of Biomimetic Materials & Chemistry Anhui Engineering Laboratory of Biomimetic Materials Division of Nanomaterials & Chemistry Hefei National Research Center for Physical Sciences at the Microscale University of Science and Technology of China Hefei 230026 China Department Faculty of Material and Chemistry China University of Geosciences Wuhan 430074 China Authors' Affiliations: Departments of 1Thoracic Surgery and 2Pathology, Fudan University Shanghai Cancer Center; 3Department of Oncology, Shanghai Medical College, Fudan University; 4Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institute for Biological Science, Chinese Academy of Science; and 5Promed Cancer Centers, Shanghai, China; Authors' Affiliations: Departments of 1Thoracic Surgery and 2Pathology, Fudan University Shanghai Cancer Center; 3Department of Oncology, Shanghai Medical College, Fudan University; 4Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institute for Biological Science, Chinese Academy of Science; and 5Promed Cancer Centers, Shanghai, China Department of Physics & Institute for Quantum Science and Engineering, Southern University of Science and Technology, Shenzhen 518055, People’s Republic of China; Institute for Structure and Function & Department of Physics, Chongqing University, Chongqing 400044, People’s Republic of China Tsinghua University Institute of Theoretical and Computational Chemistry, Shaanxi Key Laboratory of Catalysis, School of Chemical & Environment Science, Shaanxi University of Technology, Hanzhong, Shaanxi 723001, P. R. China State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, Pukou District, Nanjing, China Hubei Key Laboratory of Ferro & Piezoelectric Materials and Devices, School of Microelectronics and Faculty of Physics and Electronic Science, Hubei University, Wuhan 430062, P. R. China Key Laboratory of Coastal Environmental Processes and Ecological Remediation; The Research Centre for Coastal Environmental Engineering and Technology; Yantai Institute of Coastal Zone Research; Chinese Academy of Sciences; Yantai 264003 Developmental Neurobiology Max‐Delbrück‐Center Robert‐Rössle‐Str. 10 13092 Berlin Germany Department of Materials Science and Engineering, University of California , Los Angeles, California 90095, United States State Key Laboratory of Tree Genetics and Breeding, Northeast Forestry University , Harbin 150040 , China State Key Laboratory for Biology of Plant Diseases and Insect Pests Institute of Plant Protection, Chinese Academy of Agricultural Science Beijing China Department of Population Medicine, Harvard Pilgrim Health Care Institute and Harvard Medical School, Boston, MA, USA; Department of Biostatistics, Harvard University, Boston, MA, USA Department of Genetic Medicine, Weill Cornell Medical College, New York, NY, 10065. Department of Radiology , The First Affiliated Hospital of Anhui Medical University, Hefei 230022 , China; Research Center of Clinical Medical Imaging , Anhui Province, Hefei 230032 , China; Anhui Provincial Institute of Translational Medicine , Hefei 230032, China Department of Pharmacology, College of Pharmacy, Dalian Medical University, Dalian, Liaoning Province, China State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China; Joint International Research Laboratory of Metabolic & Developmental Sciences, Shanghai Jiao Tong University, Shanghai 200240, China; Biomass Energy Research Center, Shanghai Jiao Tong University, Shanghai 200240, China Michigan Center for Translational Pathology Reproductive Medicine Center, Tongji Hospital, Tongji Medicine College, Huazhong University of Science and Technology, Wuhan, Hubei, China QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia Department of Medical Oncology, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, China Harvard Pilgrim Health Care Institute, Department of Population Medicine, Harvard Medical School, Boston, Massachusetts; Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, Massachusetts Department of Chemistry and Laboratory of Advanced Materials, Fudan University, Shanghai 200433, P. R. China Center for Bioelectronics and Biosensors, the Biodesign Institute, School for Engineering of Matter, Transport, and Energy, and School of Electrical, Computer, and Energy Engineering, Arizona State University, Tempe, Arizona 85287, United States Department of Gastroenterology, Nursing Section, West China Hospital, Sichuan University, Chengdu, China Department of Mathematics Michigan State University Michigan USA Department of Biology, Lakehead University, Thunder Bay, Ontario P7B 5E1, Canada.; Cardiovascular and Metabolic Research Unit, Lakehead University, Thunder Bay, Ontario P7B 5E1, Canada. Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of China Chengdu 610054 P. R. China Division of Sleep Medicine and Circadian Disorders, Department of Medicine, Brigham and Women’s Hospital, Boston, Massachusetts; Harvard Medical School, Boston, Massachusetts; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts Department of Endocrinology Department of Population Medicine, Harvard Pilgrim Health Care Institute and Harvard Medical School, Boston, Massachusetts Intensive Care Unit, Qilu Hospital of Shandong University (Qingdao), Qingdao, Shandong 266035, P.R. China CAS Key Laboratory of Coastal Environmental Processes and Ecological Remediation; Yantai Institute of Coastal Zone Research; Chinese Academy of Sciences; Yantai 264003; China The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450000, China. Department of Hepatobiliary Surgery, Haikou People's Hospital/Affiliated Haikou Hospital of Xiangya Medical College Central South University Haikou Hainan People's Republic of China State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China; Graduate School of Chinese Academy of Sciences, Beijing 100049, P. R. China College of Food Science and Engineering, National R&D Branch Center of Surimi and Surimi Products Processing Bohai University Jinzhou China Division of Nanomaterials and Chemistry, Hefei National Laboratory for Physical Sciences at the Microscale, Institute of Energy, Hefei Comprehensive National Science Center, CAS Center for Excellence in Nanoscience, Department of Chemistry, Institute of Biomimetic Materials and Chemistry, Anhui Engineering Laboratory of Biomimetic Materials, University of Science and Technology of China, Hefei, Anhui 230026, China Province-Ministry Co-construction Collaborative Innovation Center of Hebei Photovoltaic Technology, College of Physics Science and Technology, Hebei University, Baoding 071002, China Department of Biology, Lakehead University, Thunder Bay, ON, Canada P7B 5E1 Center for the Study of Language and Information, Stanford University, Stanford, CA 94305 Department of Epidemiology and Health Statistics, Fujian Provincial Key Laboratory of Environment Factors and Cancer, School of Public Health Fujian Medical University Fujian China; Laboratory Center, The Major Subject of Environment and Health of Fujian Key Universities, School of Public Health Fujian Medical University Fujian China State Key Laboratory for Cellular Stress Biology, School of Life Sciences, Xiamen University, Fujian 361005, China Department of Neurosurgery Fujian Medical University Union Hospital Fuzhou China Department of Gastroenterology and Endoscopy Center, West China Hospital, Sichuan University, Chengdu 610041, China College of Chemistry and Molecular Engineering; Zhengzhou University; Zhengzhou 450001; China College of Polymer Science and Engineering; State Key Laboratory of Polymer Materials Engineering; Sichuan University; Chengdu 610065; China Jiangsu Key Laboratory of New Power Batteries Jiangsu Collaborative Innovation Center of Biomedical Functional Materials School of Chemistry and Materials Science Nanjing Normal University Nanjing 210023 China Department of Plastic and Reconstructive Surgery Wake Forest University School of Medicine Medical Center Blvd Winston‐Salem North Carolina 27157; Virginia Tech ‐ Wake Forest University School of Biomedical Engineering and Science Medical Center Blvd Winston‐Salem North Carolina 27157 Shaanxi Ophthalmic Medical Center, School of Medicine, Xi'an No.4 Hospital Affiliated Guangren Hospital, Xi'an Jiaotong University Xi'an China Department of Biology Lakehead University Thunder Bay Ontario Canada Cardiovascular and Metabolic Research Unit, Laurentian University, Sudbury, Ontario, Canada Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Institute of Biochemistry and Molecular Biology, School of Life Sciences Lanzhou University 222 Tian Shui South Road Lanzhou 730000 China Department of Endodontics, School and Hospital of Stomatology, China Medical University, Liaoning Provincial Key Laboratory of Oral Disease, Cental Laboratory, School of Stomatology, China Medical University. Shenyang 110002,Liaoning Province, China. E-mail: 737419245@qq.com. State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China; Department of Experimental Radiation Oncology, the University of Texas MD Anderson Cancer Center, Houston, TX, USA Molecular Pharmacology and Chemistry Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, United States; Program of Pharmacology, Weill Graduate School of Medical Science, Cornell University, New York, New York 10021, United States Department of Stem Cells and Regenerative Medicine, Key Laboratory of Cell Biology, National Health Commission of China, and Key Laboratory of Medical Cell Biology, Ministry of Education of China, China Medical University, Shenyang, China; Institute of Drug Design & Synthesis Institute of Pharmacology Key Laboratory of Preclinical Study for New Drugs of Gansu Province School of Basic Medical Science Lanzhou University 199 West Donggang Road Lanzhou 730000 China Department of Biochemistry & Molecular Biology, School of Life Sciences, Lanzhou University, Lanzhou, Gansu 730000, China, and State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, Gansu 730000, China wangrui@lzu.edu.cn Rui Wang is a medical student at Harvard Medical School. Faculty of Medicine, Nursing and Health Sciences Monash University Melbourne Victoria Australia; Discipline of Obstetrics & Gynaecology School of Medicine and Robinson Research Institute The University of Adelaide Adelaide South Australia Australia Department of Plastic and Reconstructive Surgery Wake Forest University Health Sciences Winston‐Salem North Carolina New York State Psychiatric Institute, New York (Smith, Haselden, Corbeil, Wall, Dixon, Olfson); Department of Psychiatry, Columbia University Vagelos College of Physicians and Surgeons, New York (Smith, Essock, Dixon); Office of Performance Measurement and Evaluation, New York State Office of Mental Health, Albany (Tang, Radigan, Wang, Frimpong); Department of Psychiatry, University of Rochester Medical Center, Rochester, New York (Lamberti); Department of Psychiatry and Behavioral Sciences, Albert... State Key Laboratory for Agro-Biotechnology, College of Biological Sciences, China Agricultural University, Beijing, 100193, PR China Cardiovascular and Metabolic Research Unit, Lakehead University, Thunder Bay, Canada P7A 7T1; Cardiovascular and Metabolic Research Unit, Laurentian University, Canada P3E 2C6; Department of Biology, Laurentian University, Canada P3E 2C6 Center for Biostatistics in AIDS Research, Harvard School of Public Health, Boston, Massachusetts 02115. Hebei Key Laboratory of Optic‐electronic Information and Materials College of Physics Science and Technology Hebei University Baoding 071002 P. R. China State Key Laboratory for Agrobiotechnology and Key Laboratory of Crop Heterosis and Utilization (MOE) and Beijing Key Laboratory of Crop Genetic Improvement China Agricultural University Beijing 100193 China Key Laboratory of Preclinical Study for New Drugs of Gansu Province, and Institute of Physiology, School of Basic Medical Sciences Lanzhou University Lanzhou China Department of Chemistry and ‡The RNA Institute, University at Albany, State University of New York, 1400 Washington Avenue, Albany, New York 12222, United States National Center for Nanoscience and Nanotechnology of China, Zhongguancun, Beijing 100190, People’s Republic of China Department of Thoracic Surgery, The First Hospital of Jilin University, Changchun, China Department of Radiology, Beijing Anzhen Hospital, Capital Medical University Jiangsu Key Laboratory for Microbes and Microbial Functional Genomics, Jiangsu Engineering and Technology Research Center for Industrialization of Microbial Resources, College of Life Science, Nanjing Normal University, Nanjing 210023, PR China Department of Urology, First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116000, China Department of Neuroscience, Max-Delbrück Center for Molecular Medicine and Charité Universitätsmedizin Berlin, Berlin-Buch Germany Department of Parasitology, Medical College, Zhengzhou University, Zhengzhou 450052, China. School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, China. Shanghai Center for Plant Stress Biology and Center for Excellence in Molecular Plant Sciences, Chinese Academy of Sciences, Shanghai 200032, China; University of Chinese Academy of Sciences, Beijing 100049, China School of Information Engineering Nanchang University Nanchang China; Ji luan Academy Nanchang University Nanchang China The Centre of Nanoscale Science and Technology and Key Laboratory of Functional Polymer Materials Institute of Polymer Chemistry College of Chemistry and Renewable Energy Conversion and Storage Center (RECAST) Nankai University Tianjin 300071 China Department of Chemistry & State Key Laboratory of Molecular Engineering of Polymers, Fudan University Department of Obstetrics and Gynaecology, Monash University, Clayton, VIC, Australia r.wang@monash.edu. State Key Laboratory of Solid Lubrication, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, People’s Republic of China National University of Defense Technology Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling 712100, China; Center for Ruminant Genetics and Evolution, Northwest A&F University, Yangling 712100, China School of Life Sciences, Key Laboratory of Preclinical Study for New Drug of Gansu Province, Lanzhou University Lanzhou 730000, P.R. China Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, State Key Laboratory of Applied Organic Chemistry and Institute of Biochemistry and Molecular Biology, Lanzhou University, Lanzhou, 730000, China College of Food Science and Technology, Zhejiang University of Technology Hangzhou China; Key Laboratory of Marine Fishery Resources Exploitment and Utilization of Zhejiang Province Hangzhou China; National R&D Branch Center for Pelagic Aquatic Products Processing (Hangzhou) Hangzhou China; Collaborative Innovation Center of Seafood Deep Processing Dalian Polytechnic University Dalian China Department of Medicine, Brigham and Women’s Hospital and Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts; School of Pharmacy, Ningxia Engineering and Technology Research Center for Modernization of Traditional Chinese Medicine, and Key Laboratory of Traditional Chinese Medicine Modernization, Ministry of Education, Ningxia Medical University Center of Integrative Medicine College of Veterinary Medicine, Henan Agricultural University, Zhengzhou 450046, China; International Joint Research Center of National Animal Immunology, College of Veterinary Medicine, Henan Agricultural University, Zhengzhou 450046, China Division of Nephrology, Renmin Hospital of Wuhan University, Wuhan, China EMBL Outstation, European Bioinformatics Institute (EBI) Wellcome Trust Genome Campus Hinxton Cambridge UK Department of Nephrology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China University of Chinese Academy of Science, Beijing 100049, PR China; State Key Laboratory of Multiphase Complex Systems, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, PR China Laboratory of Nutrition Beijing Pediatric Research Institute Beijing Children's Hospital Capital Medical University National Center for Children's Health Beijing 100045 China Department of Ultrasound, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China | Hubei Province Key Laboratory of Molecular Imaging, Wuhan, China Department of Hematology, Qilu Hospital, Shandong University, Jinan, China Key Laboratory of Preclinical Study for New Drugs of Gansu Province, Institute of Biochemistry and Molecular Biology, State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, China, and State Key Laboratory of Chiroscience, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Kowloon, Hong Kong Dr. Ben-Zeev and Ms. Brian are with the Psychiatric Research Center and the Department of Psychiatry, Dr. Scherer is with the Department of Community and Family Medicine and the Department of Biomedical Data Science, and Dr. Mistler is with the Department of Psychiatry, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire (e-mail: ). Mr. Wang and Dr. Campbell are with the Department of Computer Science, Dartmouth College, Hanover, New Hampshire. Mr. Abdullah and Dr. Choudhury are with the... Division of Nanophotonics CAS Key Laboratory of Standardization and Measurement for Nanotechnology CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology Beijing 100190 P. R. China Department of Anesthesiology The First Affiliated Hospital of Xi'an Jiaotong University Xi'an Jiaotong University Xi'an Shaanxi China Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institute and Stockholm University, Stockholm SE-17177, Sweden School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China; Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, China Department of Medical Oncology First Affiliated Hospital of Bengbu Medical College 287 Changhuai Rd. Bengbu Anhui 233 000 China SenseTime Research, Beijing 100080China Department of Vascular Surgery Yantai Yuhuangding Hospital Yantai Shandong China Department of Urology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, China Key Laboratory of Wide Band Gap Semiconductor Technology School of Advanced Materials and Nanotechnology Xidian University Xi'an 710071 China California Institute of Technology Division of Chemistry and Chemical Engineering, , Pasadena, California 91125, USA College of Materials and Chemistry, China Jiliang University, Hangzhou, 310018, China Key Laboratory of Preclinical Study for New Drugs of Gansu Province, State Key Laboratory of Applied Organic Chemistry and Institute of Biochemistry and Molecular Biology, Lanzhou University, Lanzhou, 730000 China; Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Kowloon, Hong Kong CAS Key Laboratory of Design and Assembly of Functional Nanostructures; Fujian Provincial Key Laboratory of Nanomaterials; Fujian Institute of Research on the Structure of Matter; Chinese Academy of Sciences; Fuzhou College of Biomass Science and Engineering Sichuan University Chengdu 610065 P. R. China; Chengdu Product Quality Supervision and Inspection Institute Chengdu 610065 P. R. China The First Affiliated Hospital of Qiqihar Medical University, Qiqihar Medical University, Qiqihar, 161000 Heilongjiang, China Department of Oral and Maxillofacial-Head Neck Oncology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China.; College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai 200011, China. Division of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women’s Hospital, Boston MA; Division of Sleep Medicine, Harvard Medical School, Boston, MA; Department of Biostatistics, Harvard University T.H. Chan School of Public Health, Boston, MA; Department of Population Medicine, Harvard Pilgrim Health Care Institute, Boston, MA Department of Medical Psychology and Ethics School of Basic Medical Medicine Sciences Cheeloo College of Medicine Shandong University Jinan P.R. China Division of Nanomaterials & Chemistry Hefei National Research Center for Physical Sciences at the Microscale Institute of Energy Hefei Comprehensive National Science Center Department of Chemistry Institute of Biomimetic Materials & Chemistry Anhui Engineering Laboratory of Biomimetic Materials University of Science and Technology of China Hefei 230026 China Department of Health Statistics, Second Military Medical University, Shanhgai 200433, China. Department of Psychiatry, Columbia University Vagelos College of Physicians and Surgeons, New York City (Smith, Wall, Essock, Dixon, Olfson, Lewis-Fernández); Office of Performance Measurement and Evaluation, New York State Office of Mental Health, Albany (Tang, Frimpong, Radigan, Wang); Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco (Goldman). Key Laboratory of MEMS of the Ministry of Education Southeast University Nanjing 210096 China Shanghai Frontier Science Research Base of Optogenetic Techniques for Cell Metabolism, School of Pharmacy, East China University of Science and Technology, Shanghai, China Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, P.R. China Henan Key Laboratory of Crystalline Molecular Functional Materials Henan International Joint Laboratory of Tumor Theranostical Cluster Materials Green Catalysis Center and College of Chemistry Zhengzhou University Zhengzhou 450001 P. R. China Key Laboratory of Soybean Biology in Chinese Ministry of Education Northeast Agricultural University Harbin China Key Laboratory of Clinical Laboratory Diagnostics of the Ministry of Education, Chongqing Medical University, Chongqing 400016, China. Key Laboratory of Preclinical Study for New Drugs of Gansu Province School of Basic Medical Sciences Lanzhou University Lanzhou China College of Pharmaceutical Sciences, Key Laboratory of Luminescent and Real-Time Analytical Chemistry (Southwest University), Ministry of Education, Southwest University, Chongqing, P.R. China Laboratory of Stem Cell and Tissue Engineering, Orthopedic Research Institute, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, P.R. China. Institute of Cotton, Anhui Academy of Agricultural Sciences, Hefei, China Department of Stem Cells and Regenerative Medicine, Key Laboratory of Cell Biology, National Health Commission of China, and Key Laboratory of Medical Cell Biology, Ministry of Education of China, China Medical University, Shenyang, China School of Psychology Shenzhen University Shenzhen China Beijing Key Laboratory of Clothing Materials R & D and Assessment, Beijing Engineering Research Center of Textile Nanofiber, School of Materials Design & Engineering, Beijing Institute of Fashion Technology, Beijing 100029, China College of Veterinary Medicine, Northeast Agricultural University, Harbin, People's Republic of China Department of Preventive Medicine, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China Division of Chemistry, Department of Biochemistry University of Texas Southwestern Medical Center 5323 Harry Hines Blvd., Dallas, Texas 75390-9038, USA. shairwang@gmail.com. Department of Thoracic Surgery and Oncology, China State Key Laboratory of Respiratory Disease and National Clinical Research Center for Respiratory Disease, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China; Nanshan School, Guangzhou Medical University, Guangzhou, China Department of Mathematics, Michigan State University, MI 48824, USA. Department of Microbiology, New York University School of Medicine, New York, NY 10016 Department of Gastroenterology, West China Hospital, Sichuan University, Chengdu 610041, China The Key Laboratory of Microelectronics Device and Integrated Technology; Institute of Microelectronics; Chinese Academy of Sciences; Beijing 100029; China Aging Research Center Department of Neurobiology Care Sciences and Society Karolinska Institutet–Stockholm University Stockholm Sweden Department of Gastroenterology, Tianjin Medical University General Hospital, Tianjin 300052, China Harbin Institute of Technology Department of Physiology, Department of Pharmacology, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada S7N 5E5 Departments of aMicrobiology, Jiangsu Collaborative Innovation Centre of Biomedical Functional Materials and Jiangsu key Laboratory of Biofunctional Materials; School of Chemistry and Materials Science; Nanjing Normal University; Nanjing; P. R. China Department of Chemistry and Nanoscience Ewha Womans University Seoul 03760 Republic of Korea Department of Obstetrics and Gynecology, Monash University, Clayton, Australia Beijing Key Laboratory of Blood Safety and Supply Technologies & Blood Products and Substitute Laboratory Beijing Institute of Transfusion Medicine Beijing China Department of Radiology, Peking University First Hospital, No. 8 Xishiku Street, Xicheng District, Beijing 100034, China School of Microelectronics and Control Engineering, Changzhou University, Changzhou 213159, China College of Plant Sciences Jilin University Changchun 130062 China 1Memorial Sloan Kettering Cancer Center, New York, New York. Beijing You’an Hospital Capital Medical University 8, Xi Tou Tiao, Youanmen wai Fengtai District Beijing 100069 China Department of Biomedical Sciences, College of Veterinary Medicine and Life Science, City University of Hong Kong, Hong Kong SAR, China; Tung Biomedical Sciences Centre, City University of Hong Kong, Hong Kong SAR, China Collaborative Innovation Center for Optoelectronic Science and Technology and Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province; Shenzhen University; Shenzhen 518060; P. R. China; Department of Electronic Engineering National Laboratory of Solid State Microstructures School of Physics and Collaborative Innovation Center for Advanced Microstructures Nanjing University Nanjing 210093 P. R. China Agro-Environmental Protection Institute, Ministry of Agriculture, Tianjin 300191, China. College of Agriculture and Environmental Resources, Tianjin Agriculture University, Tianjin 300384, China. Pharmaceutical Research Institute, Wuhan Institute of Technology, Wuhan 430205, China; School of Chemical Engineering & Pharmacy, Wuhan Institute of Technology, Wuhan 430205, China Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Institute of Biochemistry and Molecular Biology, School of Life Sciences, , Lanzhou University, Lanzhou 730000, China State Key Laboratory of Applied Organic Chemistry; Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province; and College of Chemistry and Chemical Engineering; Lanzhou University; Lanzhou Cardiovascular and Metabolic Research Unit, Lakehead University, Ontario, Canada.; Department of Biology, Lakehead University, Ontario, Canada. School of Physics Nanjing University Nanjing 210093 China State Key Laboratory of Earth Surface Processes and Resource Ecology, College of Global Change and Earth System Science, Beijing Normal University , Beijing 100875 , China School of Pharmaceutical Sciences, Capital Medical University, Beijing 100069, China Henan Institute of Science and Technology, Key Discipline Open Lab on Crop Molecular Breeding of Henan Institute of Higher Learning, Cotton Research Institute MLR Key Laboratory of Metallogeny and Mineral Assessment, Institute of Mineral Resources, Chinese Academy of Geological Sciences, Beijing 100037, China. National Laboratory of Solid State Microstructures School of Physics, and Collaborative Innovation Center of Advanced Microstructures Nanjing University Nanjing 210093 China Department of Physics, Chongqing University, Chongqing 401331, China School of Basic Medical Sciences, Lanzhou University, Lanzhou, Gansu 730000, China Department of Health Statistics (YZ, LS, RW, YX); Department of Epidemiology (HS); Tangdu Hospital (DL); Sanatorium Center for Retired Cadre (RZ), Fourth Military Medical University, Xi'an, China Jiangsu Provincial Key Laboratory of Drug Metabolism and Pharmacokinetics, Research Unit of PK-PD Based Bioactive Components and Pharmacodynamic Target Discovery of Natural Medicine of Chinese Academy of Medical Sciences, China Pharmaceutical University, China Department of Sport Rehabilitation, Shanghai University of Sport, Shanghai, China School of Materials Science and Engineering, Zhejiang Sci-Tech University, Hangzhou, China; International Scientific and Technological Cooperation Base of Intelligent Biomaterials and Functional Fibers, Hangzhou, China School of Biomedical Engineering, Shanghai Jiao Tong University; Shanghai China School of Materials Science and Engineering, Zhejiang Sci-Tech University, Hangzhou, 310018, China; International Scientific and Technological Cooperation Base of Intelligent Biomaterials and Functional Fibers of Zhejiang Province, Hangzhou, 310018, China Central Hospital affiliated to Shenyang Medical College Shenyang Liaoning China The State Key Laboratory of Mechanics and Control of Mechanical Structures, Laboratory of Intelligent Nano Materials and Devices of Ministry of Education, College of Aerospace Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing 210016, China; School of Material Science and Technology, Nanjing University of Aeronautics and Astronautics, Nanjing 210016, China Department of Mental Health The First Hospital of Jilin University Changchun China School of Pharmacy, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai, 201203, People’s Republic of China College of Food Science and Light Industry, Nanjing Tech University , Nanjing 211816 , P.R. China Department of Population Medicine, Harvard Medical School/Harvard Pilgrim Health Care Institute, Boston, Massachusetts College of Basic Medical Science, China Three Gorges University iGaN Laboratory School of Microelectronics University of Science and Technology of China Hefei Anhui 230026 China Department of Chemistry and Nanoscience, Ewha Womans University, Seoul 03760, Korea Key Laboratory of Food Quality and Health of Tianjin, State Key Laboratory for Food Nutrition and Safety, College of Food Engineering and Biotechnology, Tianjin University of Science and Technology, Tianjin, 300457, China PingAn Technology (Shenzhen) Co., Ltd., Shenzhen, China College of Chemistry and Chemical Engineering and ‡Innovation Base of Energy and Chemical Materials for Graduate Students Training, Central South University, Changsha, Hunan 410083, P.R. China Institutes of Physical Science and Information Technology, School of Materials Science and Engineering, Leibniz International Joint Research Center of Materials Sciences of Anhui Province, Anhui Province Key Laboratory of Environment-Friendly Polymer Materials, Key Laboratory of Structure and Functional Regulation of Hybrid Material (Ministry of Education), Anhui University, Hefei 230601, China Key Laboratory of Green Prevention and Control of Tropical Diseases and Pests, Ministry of Education, School of Tropical Agriculture and Forestry, Hainan University, Haikou 570228, China; Engineering Center of Agricultural Microbial Preparation Research and Development of Hainan, Hainan University, Haikou 570228, China; Sanya Institute of Breeding and Multiplication, Hainan University, Sanya 572025, China School of Art Hubei University Wuhan 430062 China College of Life Sciences, Jilin Agricultural University, Changchun, Jilin, China Department of Pathology, The First Hospital of China Medical University and College of Basic Medical Sciences, China Medical University Key Laboratory of Precision Opto-Mechatronics Technology, Ministry of Education, The School of Istrumentation Science and Opto-Electronics Engineering, Beihang University, Beijing, 100191, China Wuhan National Laboratory for Optoelectronics Huazhong University of Science and Technology Wuhan Hubei 430074 P. R. China; School of Computer Science and Technology Huazhong University of Science and Technology Wuhan Hubei 430074 P. R. China National Center for Nanoscience and Technology, Beijing 100190, China, State Key Laboratory of Pharmaceutical Biotechnology and The Comprehensive Cancer Center Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, School of Life Sciences, Nanjing University Nanjing China Tianjin Medical University 300070 Tianjin, People’s Republic of China; Key Laboratory of Tissue Repair and Regeneration of PLA, and Beijing Key Research Laboratory of Skin Injury, Repair and Regeneration Fourth Medical Center of General Hospital of PLA 100048 Beijing, People’s Republic of China Institute of Biochemistry and Molecular Biology and State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, China; State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China College of Pharmaceutical Sciences, Key Laboratory of Luminescent and Real-Time Analytical Chemistry (Southwest University), Ministry of Education, Southwest University , Chongqing, P.R. China Department of Intensive Care Unit, The First Affiliated Hospital of Xinjiang Medical University, Urumchi, China College of Basic Medical Science, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, China; Key Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine), Ministry of Education, Harbin, Heilongjiang, China CAS Key Laboratory of Standardization and Measurement for Nanotechnology, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, People’s Republic of China State Key Laboratory of Power Systems Department of Electrical Engineering Tsinghua University Beijing 100084 China Key Laboratory of Emergency and Trauma, Ministry of Education, Key Laboratory of Hainan Trauma and Disaster Rescue, The First Affiliated Hospital of Hainan Medical University, Institute of Functional Materials and Molecular Imaging, College of Emergency and Trauma, Hainan Medical University, Haikou 571199, China Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China. Nursing Section, Department of Gastroenterology. Authors' Affiliation: State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan, People's Republic of China Wenzhou University of Technology, 325000 Wenzhou, China Department of Physiology, University of Saskatchewan, Saskatchewan, Canada, S7N 5E5 Department of Microbiology, New York University School of Medicine, New York; and Department of Biochemistry and Molecular Biology, School of Life Sciences, Lanzhou University, Lanzhou, Gansu 730000, China, and State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, Gansu 730000, China Department of Toxicology, School of Public Health , Jilin University , Changchun , Jilin Province , China Authors' Affiliations: 1Michigan Center for Translational Pathology, 2National Center for Integrative Biomedical Informatics, Center for Computational Medicine and Bioinformatics, and 3Departments of Pathology and 5Urology, 4Howard Hughes Medical Institute, and 6Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, Michigan; 7Departments of Pathology and Laboratory Medicine and 8Urology, Weill Cornell Medical College, and 11Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, New York; 9Beth Israel Deaconess Medical Center, Division of Signal Transduction, and Departments of Medicine and 10Systems Biology, Harvard Medical School, Boston, Massachusetts; Authors' Affiliations: 1Michigan Center for Translational Pathology, 2National Center for Integrative Biomedical Informatics, Center for Computational Medicine and Bioinformatics, and 3Departments of Pathology and 5Urology, 4Howard Hughes Medical Institute, and 6Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, Michigan; 7Departments of Pathology and Laboratory Medicine and 8Urology, Weill Cornell Medical College, and 11Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, New York; 9Beth Israel Deaconess Medical Center, Division of Signal Transduction, and Departments of Medicine and 10Systems Biology, Harvard Medical School, Boston, Massachusetts College of Animal Sciences, Jilin University, Changchun 130062, China Institutes of Physical Science and Information Technology Leibniz Joint Research Center of Materials Sciences Engineering Laboratory of High‐Performance Waterborne Polymer Materials of Anhui Province Key Laboratory of Structure and Functional Regulation of Hybrid Material (Ministry of Education) Anhui University Hefei 230601 China Key Laboratory of the Ministry of Education for Medicinal Resources and Natural Pharmaceutical Chemistry, National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest of China, and School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi’an 710119, People’s Republic of China Department of Anorectal, Yantai Hospital of Traditional Chinese Medicine, Yantai, Shandong, China; Department of General Surgery, Yantai Hospital of Traditional Chinese Medicine, Yantai, Shandong, China Plastic and Reconstructive SurgeryWake Forest University School of Medicine Winston‐Salem North Carolina; Biomedical Engineering and ScienceVirginia Tech‐Wake Forest University School of Biomedical Engineering and Science Winston‐Salem North Carolina Institute of Pharmacology, Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University, Lanzhou, 730000, China; State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China; Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin 300071, China Key Laboratory of Microelectronics Device & Integrated Technology Institute of Microelectronics of Chinese Academy of Sciences Beijing 100029 China; University of Chinese Academy of Sciences Beijing 100049 China Key Laboratory of Magnetic Molecules and Magnetic Information Materials of Ministry of Education; The School of Chemistry and Materials Science; Shanxi Normal University; Linfen 041004; China Department of Endocrinology, the First Hospital of Qinhuangdao, Qinhuangdao, Hebei Province, PR China Department of Gastrointestinal Surgery, Harbin Medical University Cancer Hospital, 150 Haping Road, Nangang District, Harbin 150081, China College of Chemistry, Beijing Normal University, Beijing 100875, China Department of Chemistry, Collaborative Innovation Center of Chemistry for Energy Materials, State Key Laboratory of Molecular Engineering of Polymers, Fudan University, Shanghai 200433, People’s Republic of China Department of Radiology Peking University First Hospital Beijing China Key Laboratory for Advanced Materials, Feringa Nobel Prize Scientist Joint Research Center, Frontiers Science Center for Materiobiology and Dynamic Chemistry, Institute of Fine Chemicals, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai, 200237, P. R. China Department of Nursing, Medical College of Nursing, Huzhou University, Huzhou, People’s Republic of China Department of Orthopaedics Surgery, Tianjin Medical University General Hospital, Tianjin, China; Department of Orthopaedics Surgery, Tianjin Medical University General Hospital, Tianjin, China State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, P. R. China Department of Biomedical Sciences, City University of Hong Kong, Kowloon, Hong Kong SAR, China Tianjin Medical University Tianjin China; Key Laboratory of Tissue Repair and Regeneration of PLA, and Beijing Key Research Laboratory of Skin Injury, Repair and Regeneration First Hospital Affiliated to General Hospital of PLA Beijing China State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Pediatric Dentistry, West China Hospital of Stomatology Sichuan University Chengdu China; Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, Department of Orthodontics, College of Stomatology Xi'an Jiaotong University Xi'an China Department of Pharmacy Center of Medicine Clinical Research Chinese PLA General Hospital Beijing China Institute of Intelligent Machines, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, P. R. China; Science Island Branch, Graduate School of USTC, Hefei 230026, P. R. China Department of Orthopaedic Surgery, Tianjin Medical University General Hospital, Tianjin, China; Tianjin Neurological Institute, Key Laboratory of Post-Neuroinjury Neuro-repair and Regeneration in Central Nervous System, Ministry of Education and Tianjin City, Tianjin, China. Department of Oncology, Wayne State University School of Medicine, Detroit, MI, USA; Department of Diagnostics of Chinese Medicine, Hebei University of Chinese Medicine, Hebei, China College of Food Science and Light Industry Nanjing Tech University Nanjing China; State Key Laboratory of Materials‐Oriented Chemical Engineering Nanjing Tech University Nanjing China Department of Occupational Health and Radiation Protection, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051, China; School of Public Health, Suzhou Medical College, Soochow University, Suzhou 215123, China Department of Radiology, China‑Japan Union Hospital of Jilin University, Changchun, Jilin 130033, P.R. China MGH Biostatistics Center, Massachusetts General Hospital, Boston, MA 02114, USA.; Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115, USA. Department of Gastroenterology, West China Hospital, Sichuan University, Chengdu, China;; Laboratory of Gastroenterology and Hepatology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China; Department of Etiologic Biology, the Second Military Medical University, Shanghai, China. The Centre of Nanoscale Science and Technology Key Laboratory of Functional Polymer Materials Institute of Polymer Chemistry College of Chemistry Nankai University Tianjin 300071 China 1Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China. Department of Endocrinology General Hospital of Shenyang Military Region Shenyang China 1Department of Radiology, Peking University First Hospital, Beijing, China. Department of Electronic and Electrical Engineering, Southern University of Science and Technology, No 1088, Xueyuan Road, Nanshan District, Shenzhen, Guangdong 518055, People’s Republic of China Key Laboratory of Wide Band Gap Semiconductor Technology, School of Advanced Materials and Nanotechnology, Xidian University, Xi’an 710071, China Laboratory of Nuclear Receptors & Cancer Research, Basic Medical Research Center, Nantong Key Laboratory of Microenvironment and Cancer Translational Medicine Nantong University School of Medicine Nantong 226001 Jiangsu People's Republic of China Key Laboratory of Dairy Science; Ministry of Education; Department of Food Science; Northeast Agricultural University; Harbin College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, China; International Joint Research Center of National Animal Immunology, Henan Agricultural University, Zhengzhou, China Open Laboratory of Chirotechnology, Department of Biochemistry and Molecular Biology, School of Life Science, Lanzhou University, Lanzhou 730000, P. R. China, and Open Laboratory of Chirotechnology, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong, P. R. China Department of Pharmacology; Key Laboratory of Preclinical Study for New Drugs of Gansu Province; School of Basic Medical Sciences; Lanzhou University; Lanzhou Engineering Research Center of Nano-Geomaterials of Ministry of Education, Faculty of Material and Chemistry, China University of Geosciences, Wuhan 430074, China The Centre of Nanoscale Science and Technology and Key Laboratory of Functional Polymer Materials, Institute of Polymer Chemistry, College of Chemistry, Nankai University, Tianjin 300071, China Department of Oncology Yantai Yuhuangding Hospital Yantai China Beijing Fengtai Hospital Department of Nephrology Beijing Fengtai People's Republic of China Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, 116023, China, and Key Laboratory of Preclinical Study for New Drugs of Gansu Province, Lanzhou University, Lanzhou 730000, China Department of Materials Science and Engineering, University of California, Los Angeles, CA 90095;; California NanoSystems Institute, University of California, Los Angeles, CA 90095; Department of Mechanical Engineering, College of Engineering, Shantou University, Shantou 515063, China; Intelligent Manufacturing Key Laboratory of Ministry of Education, Shantou University, Shantou 515063, China Division of Behavioral Health Services and Policy Research (Humensky, Nossel, Bello, Malinovsky, Dixon) and Division of Mental Health Data Science (Wall), New York State Psychiatric Institute, New York City; Department of Psychiatry, Columbia University Irving Medical Center, New York City (Humensky, Nossel, Bello, Malinovsky, Wall, Dixon); Office of Performance Measurement and Evaluation, New York State Office of Mental Health, Albany (Radigan, Gu, Wang); Department of Psychiatry and Behavioral... Department of Population Medicine, Harvard Pilgrim Health Care Institute, Harvard Medical School, Boston, Massachusetts Jiangsu Collaborative Innovation Center of Biomedical Functional Materials and Jiangsu Key Laboratory of Biofunctional Materials, School of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, P. R. China College of Physics, Nanjing University of Aeronautics and Astronautics, and Key Laboratory of Aerospace Information Materials and Physics (NUAA), MIIT, Nanjing211106, China Division of Comprehensive Dentistry Tohoku University Graduate School of Dentistry Sendai Japan College of Automation, Nanjing University of Science & Technology, Xiaolingwei Street, Nanjing 210094, China European Molecular Biology Laboratory, Meyerhofstrasse 1, 69012 Heidelberg, Germany; Yale University School of Medicine, Epidemiology and Public Health, 60 College Street, New Haven, CT 06520; and Université du Mali, Faculté de Médécine, de Pharmacie et d'Odonto-Stomatologie, B. P. 1805, Bamako, Mali Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States Key Lab of Organic Optoelectronics and Molecular Engineering of Ministry of Education Department of Chemistry Tsinghua University Beijing 100084 P. R. China Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences & Research Unit of Peptide Science, Chinese Academy of Medical Sciences, 2019RU066, Lanzhou University, Lanzhou, Gansu 730000, China; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China State Key Laboratory of Food Science and Technology Nanchang University Nanchang China Aging Research Center, Department of Neurobiology, Care Sciences and Society (M.D., R.W., G.K., E.J.L., Y.L., L.F., C.Q.), Karolinska Institutet, Stockholm University, Sweden.; The Swedish School of Sport and Health Sciences, GIH, Stockholm, Sweden (R.W.).; Department of Medicine and Wisconsin Alzheimer’s Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison (R.W.). *Department of Genetic Medicine, Weill Cornell Medical College, New York, NY 10065; Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, and Institute of Biochemistry and Molecular Biology, Lanzhou University, Lanzhou, 730000, P. R. China Dr. Ben-Zeev and Ms. Brian are with the Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle. Dr. Scherer is with the Department of Biomedical Data Science and the Department of Community and Family Medicine, and Dr. Mistler is with the Department of Psychiatry, Geisel School of Medicine, Dartmouth College, Lebanon, New Hampshire. Dr. Mistler is also with the Department of Psychiatry, New Hampshire Hospital, Concord. Dr. Campbell and Mr. Wang are with the Department of... Department of Orthopedics, Peking University First Hospital, Beijing, China Daqing Food and Drug Inspection Center, Daqing 163000, China. Department of Clinical Laboratory, the Second Xiangya Hospital, Central South University, Changsha 410011, China. wangrui19791121@163.com Division of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Boston, MA; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA Department of Orthopedics, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine) , Hangzhou, Zhejiang, China Department of Thoracic Surgery, the Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, China. hbssywr@sohu.com. Institute of Biochemistry & Molecular Biology, School of Life Sciences Department of Neurosurgery, Fujian Medical University Union Hospital, Fuzhou City, China Department of Surgical Oncology The University of Texas M.D. Anderson Cancer Center Houston TX USA School of Petrochemical Engineering, Jilin Institute of Chemical Technology, Jilin 132022, China Department of Gastroenterology, The Third Xiangya Hospital of Central South University, Changsha, China; Hunan Key Laboratory of Nonresolving Inflammation and Cancer, Changsha, China Department of Mathematics,Michigan State University, MI 48824, USA. Dongguan Key Laboratory of Drug Design and Formulation Technology, Key Laboratory of Research and Development of New Medical Materials of Guangdong Medical University, School of Pharmacy, Guangdong Medical University, Dongguan, 523808, PR China State Key Laboratory of Virology School of Public Health Wuhan University Wuhan China Pathology Center for Alzheimer Research–Aging Research Center, Karolinska Institutet, Stockholm University, Stockholm, Sweden College of Food Science and Engineering, Ocean University of China, Qingdao 266100, China Department of Medical Oncology, Jinling Hospital, Medical College of Nanjing University, Nanjing 210002, Jiangsu, China Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA Department of Urology, The First Hospital Affiliated to Zhengzhou University/Open Laboratory for Clinical Medicine, Key Discipline of Henan Higher Education, Zhengzhou, Henan 450052, China. huzi918@hotmail.com Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts; and Garrison Institute on Aging, Texas Tech University Health Sciences Center, Lubbock, TX, USA Institute of Fundamental and Frontier Sciences; University of Electronic Science and Technology of China; Chengdu 610054; China Department of Traditional Chinese Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R.�China 3Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, Michigan. Department of Biology, Lakehead University, Thunder Bay, Ontario, Canada National Clinical Research Center for Metabolic Diseases Key Laboratory of Diabetes Immunology (Central South University) Ministry of Education; Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University Changsha Hunan China Department of Emergency, Renmin Hospital of Wuhan University Wuhan 430060, China. Dr. Frimpong, Ms. Wang, and Dr. Radigan are with the New York State Office of Mental Health, Albany. Ms. Kuang is with the New York State Department of Health, Albany. Beijing Engineering Research Center of Protein and Antibody, Sinocelltech Ltd., Beijing 100176, China College of Surveying and Mapping, Anhui University of Science and Technology, Huainan 232001, China. Wound Healing Department, PLA Strategic Support Force Characteristic Medical Center, Beijing 100101, China VOMMA (Shanghai) Technology Co. Ltd. State Key Laboratory of Solid Lubrication, Lanzhou Institute of Chemical Physics Chinese Academy of Sciences, Lanzhou 730000, China Department of Thoracic & Cardiovascular Surgery, Nanjing Hospital Affiliated to Nanjing Medical University, Nanjing Cardiovascular Hospital, Nanjing 210006, China. Key Laboratory of Advanced Energy Materials Chemistry (Ministry of Education), College of Chemistry, Nankai University, Tianjin 300071, China; Institutes of Physical Science and Information Technology, Anhui University, Hefei 230601, China EMBL Outstation, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, U.K. College of Chemistry, Zhengzhou University, Zhengzhou 450001, China State Key Laboratory on Integrated Optoelectronics, College of Electronic Science and Engineering, Jilin University, Changchun 130012, P.R. China Department of Neurobiology, Howard Hughes Medical Institute, and Duke University Medical Center, Durham, NC 27710, USA. College of Public Health Zhengzhou University Zhengzhou China Beijing Key Laboratory of Clothing Materials R & D and Assessment; Beijing Engineering Research Center of Textile Nanofiber; School of Materials Science & Engineering; Beijing Institute of Fashion Technology; Beijing 100029 State Key Laboratory of Applied Organic Chemistry, Institute of Biochemistry and Molecular Biology, Key Laboratory of Preclinical Study for New Drugs of Gansu Province, Lanzhou University, Lanzhou 730000, China, and State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China Department of BiologyLakehead UniversityThunder BayOntarioCanada Hefei National Laboratory for Physical Science at the Microscale, Department of Chemistry, Center for Excellence in Molecular Synthesis, University of Science and Technology of China, 96 Jinzhai Road, Hefei, Anhui 230026, P. R. China State Key Laboratory of Solid Lubrication, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China Department of Cardiology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences Guangdong Cardiovascular Institute Guangzhou China State Key Laboratory of Marine Environmental Science and College of Ocean and Earth Sciences, Fujian Key Laboratory of Marine Carbon Sequestration, Xiamen University, Xiamen 361005, China. State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, Macau, China School of Chemistry and Environment, Yunnan Minzu University, Kunming, Yunnan 650500, China College of Software, Jilin University , China College of Agronomy, Anhui Agricultural University, Hefei 230036, China Department of Ophthalmology, Xi'an People’s Hospital (Xi'an Fourth Hospital) of Northwestern University, Xi'an, China Department of Physiology & Pathophysiology, College of Medicine, Fudan University, Shanghai, P.R. China.; Department of Biology, Lakehead University, Thunder Bay, Ontario, Canada. Department of Chemistry; Northwestern University; Evanston; USA Department of Thoracic Surgery First Affiliated Hospital of Xi'an Jiaotong University Xi'an Shaanxi China School of Engineering Westlake University Hangzhou 310024 China Nanjing University 1 National Laboratory of Solid State Microstructures, School of Physics, and Collaborative Innovation Center of Advanced Microstructures, , Nanjing 210093, China School of Chemical Engineering, Dalian University of Technology, Dalian 116024, China; College of Chemistry, Chemical Engineering and Resource Utilization, Northeast Forestry University, Harbin 145040, China CNNC High Energy Interest Equipment (Tianjin) Co., Ltd., Tianjin and Department of Colorectal and Anal Surgery, Linzi District People’s Hospital, Linzi, Shandong, P. R. China National Laboratory of Solid State Microstructures and School of Physics, Nanjing University, Nanjing 210093, China School of Chemistry and Chemical Engineering; University of Jinan; Jinan; China College of Food Science and Engineering, Tianjin University of Science and Technology, Tianjin, China. Department of Cosmetics, College of Chemistry and Materials Engineering Beijing Technology and Business University Beijing China; Beijing Key Laboratory of Plant Research and Development Beijing China Electronic Engineering College, Heilongjiang University, Harbin 150080, China Institute of Microscale Optoelectronics Collaborative Innovation Centre for Optoelectronic Science & Technology Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province College of Physics and Optoelectronic Engineering Shenzhen Key Laboratory of Micro‐Nano Photonic Information Technology Guangdong Laboratory of Artificial Intelligence and Digital Economy (SZ) Shenzhen University Shenzhen 518060 P. R. China; Department of Electronic Engineering Xiamen University Xiamen 361005 P. R. China Department of Chemical and Biological Engineering, The Hong Kong University of Science and Technology Clear Water Bay, Kowloon Hong Kong SAR China Department of Chemistry; University at Albany; State University of New York; USA; The RNA Institute Rui Wang, Haichuan Hu, Yunjian Pan, Yuan Li, Ting Ye, Chenguang Li, Xiaoyang Luo, Lei Wang, Hang Li, Yang Zhang, Yongming Lu, Qiong Lu, Jie Xu, Lei Shen, Yihua Sun, and Haiquan Chen, Fudan University Shanghai Cancer Center; Rui Wang, Haichuan Hu, Yunjian Pan, Yuan Li, Ting Ye, Chenguang Li, Xiaoyang Luo, Lei Wang, Hang Li, Yang Zhang, Yongming Lu, Qiong Lu, Jie Xu, Lei Shen, Yihua Sun, and Haiquan Chen, Shanghai Medical College, Fudan University; David Garfield, ProMed Cancer Centers; Fei Li and Hongbin... School of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing, 400054, China School of Life Sciences, Lanzhou University, Lanzhou 730000, China Department of Dermatology Xijing Hospital, Fourth Military Medical University Xi'an P. R. China Hefei National Laboratory for Physical Sciences at Microscale, School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230026, P.R. China; Department of Anthropotomy and Histoembryology, Medical College, Henan University of Science and Technology, Luoyang, Henan 471023, P.R. China Center of Medicine Clinical Research Department of Pharmacy Medical Supplier Center, PLA General Hospital Beijing China Key Laboratory of Microbial Technology for Industrial Pollution Control of Zhejiang Province, College of Environment, Zhejiang University of Technology, Hangzhou 310032, Zhejiang, China Materials Design & Engineering Department, Beijing Institute of Fashion Technology, Beijing 100029, China; Beijing Key Laboratory of Clothing Materials R&D and Assessment, Beijing Engineering Research Center of Textile Nanofiber, Beijing Institute of Fashion Technology, Beijing 100029, China National Laboratory of Solid-State Microstructures, School of Physics, and Collaborative Innovation Center for Advanced Microstructures, Nanjing University, Nanjing 210093, China First Hospital of Shanxi Medical University Taiyuan China Medicine Clinical Research Center, Chinese People's Liberarion Army General Hospital, 28 FuXing Road, Beijing 100853, China. Email: wangrui301@vip.sina.com. Laboratory of Drug Discovery and Design, School of Pharmaceutical Sciences, Liaocheng University, Liaocheng 252000, China Anhui Key Laboratory of Tissue Transplantation, The First Affiliated Hospital of Bengbu Medical College, Bengbu, China College of Marine Science and Environment, Dalian Ocean University, Dalian 116023, China; Key Laboratory of Environment Controlled Aquaculture, Dalian Ocean University, Ministry of Education, Dalian 116023, China School of Pharmacy, Ningxia Medical University, Yinchuan, China Key Laboratory of Cell Proliferation and Regulation Biology, Ministry of Education, College of Life Science, Beijing Normal University, Beijing, China School of Pharmacy,Heilongjiang University of Chinese Medicine Harbin 150040,China Key Laboratory of Basic and Applied Research of Northern Medicine,Ministry of Education,Heilongjiang University of Chinese Medicine Harbin 150040,China. Department of Biology York University Toronto ON Canada Department of Oncology, Hubei Provincial Hospital of Traditional Chinese Medicine, Wuhan 430065, P.R. China Key Lab of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, State Key Laboratory of Applied Organic Chemistry and Institute of Biochemistry and Molecular Biology, Lanzhou University, Lanzhou 730000, China a State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering , Lanzhou University , Lanzhou, 730000, China Department of Occupational Medicine and Environmental Toxicology, Nantong Key Laboratory of Environmental Toxicology, School of Public Health, Nantong University, Nantong 226019, China Department of Anatomy and Neurobiology, Guangzhou Medical University, Guangzhou, PR China Beijing Key Laboratory for HIV/AIDS Research, Clinical and Research Center for Infectious Diseases, Beijing You-An Hospital, Capital Medical University, Beijing, China. Beijing Neurosurgical Institute, Capital Medical University, Beijing, China State Key Laboratory of Bio-fibers and Eco-textiles, Shandong Collaborative Innovation Center of Marine Biobased Fibers and Ecological Textiles, College of Materials Science and Engineering, Institute of Marine Biobased Materials, Qingdao University, Qingdao 266071, China. Key Laboratory of Hainan Trauma and Disaster Rescue, Laboratory of Neurology, The First Affiliated Hospital of Hainan Medical University, Hainan Medical University, Haikou 571199, China; Key Laboratory of Emergency and Trauma, Ministry of Education, Key Laboratory of Hainan Functional Materials and Molecular Imaging, College of Pharmacy, College of Emergency and Trauma, Hainan Medical University, Haikou 571199, China Department of Materials Science and Engineering and California NanoSystems Institute University of California, Los Angeles Los Angeles CA 90095 USA School of Rehabilitation Medicine, Gannan Medical University, Ganzhou, Jiangxi 341000, China; Research Center of Integrated Traditional Chinese and Western Medicine, Gannan Medical University, Ganzhou, Jiangxi 341000, China Center of Nanomaterials for Renewable Energy, State Key Laboratory of Electrical Insulation and Power Equipment, School of Electrical Engineering, Xi’an Jiaotong University, Xi’an 710054, Shaanxi, China Department of Pharmacology, Key Laboratory of Ministry of Education in Fertility Preservation and Maintenance, Ningxia Medical University Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, Frontiers Science Center for Materiobiology and Dynamic Chemistry, Institute of Fine Chemicals, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai, 200237, P. R. China Department of Applied Chemistry, Anhui Agricultural University First, second, third, and fourth authors: Department of Plant Pathology, North Dakota State University, Fargo 58108; and fifth author: United States Department of Agriculture–Agricultural Research Service, Plant Science Research Unit, University of Minnesota, St. Paul 55108. Chongqing Key Laboratory for Advanced Materials and Technologies of Clean Energy Southwest University Chongqing 400715 P.R. China Department of Ultrasound, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , 1277 Jiefang Avenue, Wuhan 430022, China; Hubei Province Key Laboratory of Molecular Imaging , Wuhan 430022, China Department of Critical Care Medicine, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China (mainland) Bengbu Medical College, Bengbu, 233030, Anhui, China School of Life Sciences, Shandong University of Technology, Zibo, China Swarthmore College 1 Department of Biology , , Swarthmore, PA 19081 , USA; University of California San Diego 2 Department of Bioengineering , , La Jolla, CA 92037 , USA *Department of Microbiology, Immunology and Molecular Genetics, University of Texas Long School of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229; School of Civil and Architecture Engineering, Xi’an Technological University, Xi’an 710032, China Department of Biology (L.Z., A.U., Y.J., R.W.), Lakehead University, Thunder Bay, Ontario, Canada P7B 5E1 Key Laboratory of Coastal Environmental Processes and Ecological Remediation; Research Centre for Coastal Environmental Engineering and Technology; Yantai Institute of Coastal Zone Research; Chinese Academy of Sciences; Yantai 264003 Department of Materials Science and Engineering and California NanoSystems Institute, University of California Los Angeles, California 90095, United States Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, P.R. China The Cardiovascular and Metabolic Research Unit, Lakehead University, Ontario, Canada.; Department of Biology, Laurentian University, Ontario, Canada. Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China,Department of Psychology, University of Cambridge, Cambridge, UKwangr@psych.ac.cn The Department of Thoracic Surgery, The Fourth Affiliated Hospital of Hebei Medical University,Shijiazhuang, Hebei 050011, P.R.China. Tobacco Company of Enshi, Hubei Province, Enshi, 445000, Hubei, PR China; State Key Laboratory of Agricultural Microbiology, College of Life Science and Technology, Huazhong Agricultural University, Wuhan, 430070, PR China Institute of New Drugs Design and Synthesis, Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University, Lanzhou, China Henan Key Laboratory of Crystalline Molecular Functional Materials, Henan International Joint Laboratory of Tumor Theranostical Cluster Materials, Green Catalysis Center, and College of Chemistry, Zhengzhou University, Zhengzhou 450001, China New York State Psychiatric Institute, New York City (Smith, Haselden, Corbeil, Wall, Mascayano, Rodgers, Dixon, Olfson); Department of Psychiatry, Columbia University Vagelos College of Physicians and Surgeons, New York City (Smith, Wall, Essock, Dixon, Olfson); Office of Performance Measurement and Evaluation, New York State Office of Mental Health, Albany (Tang, Frimpong, Radigan, Wang); Department of Psychiatry and Behavioral Sciences, University of California San Francisco, San Francisco (Goldman);... The Division of Hematology/Oncology, Department of Medicine, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York. College of Life Sciences, Anhui Normal University, Wuhu 241000, PR China College of Agronomy Ningxia University Yinchuan P.R. China; Ningxia Grape and Wine Research Institute Yinchuan P.R. China; China Wine Industry Technology Institute Yinchuan P.R. China Department of Radiology, Beijing Hospital, National Center of Gerontology, No. 1 Dahua Road, Dong Dan, Beijing 100730, China Department of Biostatistics, Harvard T.H. Chan School of Public Health , Boston, Massachusetts , U.S.A.; Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital , Boston, Massachusetts , U.S.A. State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian 116023, China State Key Laboratory of Applied Organic Chemistry, Institute of Biochemistry and Molecular Biology, Key Laboratory of Preclinical Study for New Drugs of Gansu Province, Lanzhou University, Lanzhou 730000, China Department of Thyroid and Breast Surgery, The First People's Hospital of Lianyungang, Lianyungang, Jiangsu 222002, P.R. China Department of Endocrinology , The First Hospital of Qinhuangdao , Qinhuangdao , Hebei Province , P.R. China Department of Surgical Oncology, Affiliated Hangzhou Cancer Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China. School of Life Science and ‡State Key Laboratory of Tea Plant Biology and Utilization, Anhui Agricultural University, 130 West Changjiang Road, Hefei, Anhui 230036, People’s Republic of China Department of Orthopedics Peking University First Hospital Beijing China Department of Wood and Paper Science, North Carolina State University, Raleigh, NC 27695-8005, USA. Shanghai Clinical Center for Endocrine and Metabolic Diseases Shanghai Institute of Endocrinology and Metabolism Endocrine and Metabolic E‐Institutes of Shanghai Universities (EISU) and Key Laboratory for Endocrinology and Metabolism of Chinese Health Ministry Ruijin Hospital Shanghai Jiao‐Tong University School of Medicine Shanghai China Department of Medical Oncology, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, Jiangsu, China School of Pharmacy & Bioengineering, Chongqing University of Technology Department of Radiation Oncology The First Affiliated Hospital of Zhengzhou University Henan 450052 China Department of Biology, Lakehead University, Thunder Bay, Ontario, Canada. Department of Gastroenterology, Tianjin Medical University General Hospital, Tianjin, China Department of Intensive Care Unit, Affiliated Hospital of Qingdao University, Qingdao, Shandong, China College of Food Science and Light Industry Nanjing Tech University Nanjing China Department of Obstetrics and Gynaecology, Monash University, Clayton 3800, Australia; Robinson Research Institute, The University of Adelaide, Adelaide 5006, Australia Shanghai Key Laboratory of New Drug Design; Shanghai Key Laboratory of Chemical Biology; School of Pharmacy; and State Key Laboratory of Bioengineering Reactor; East China University of Science and Technology Department of Thoracic Surgery, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China (mainland) Department of Medicine, The University of Chicago, Chicago, IL, USA Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, People's Republic of China, and Cancer Research Institute, Arizona State University, PO Box 872404, Tempe, Arizona 85287-2404 Departments of Mechanical Engineering and Chemistry, The Hong Kong University of Science and Technology (HKUST), Clear Water Bay, Kowloon, Hong Kong, China, and Department of Material Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Korea Department of Reproduction and Genetics, the First Affiliated Hospital of Kunming Medical University, No. 295 Xi Chang road, Kunming, China State Key Laboratory of Solid Lubrication, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China; Shandong Laboratory of Yantai Advanced Materials and Green Manufacturing, Yantai 264000, China Department of Stem Cells and Regenerative Medicine, Key Laboratory of Cell Biology, Ministry of Public Health of China, China Medical University, Shenyang, Liaoning 110013, P.R. China Department of Pathology and Laboratory Medicine, and Waisman Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA The University of Adelaide; Robinson Research Institute and Adelaide Medical School; Norwich Centre Ground Floor, 55 King William Road Adelaide SA Australia 5006 Key Laboratory of Chinese Materia Medica, Heilongjiang University of Chinese Medicine, Ministry of Education, Harbin, People’s Republic of China Beijing Key Laboratory for HIV/AIDS Research, Beijing You‐An Hospital Capital Medical University Beijing China Beijing Key Laboratory of Gene Resource and Molecular Development Beijing Normal University Beijing 100875 China Department of Dermatology Peking University First Hospital Beijing China; National Clinical Research Center for Skin and Immune Diseases Beijing China; Beijing Key Laboratory of Molecular Diagnosis on Dermatoses Beijing China; National Medical Products Administration Key Laboratory for Quality Control and Evaluation of Cosmetics Beijing China College of Fores-try, Northwest A&F University, Yangling 712100, Shaanxi, China. Key Laboratory of Preclinical Study for New Drugs of Gansu Province, State Key Laboratory of Applied Organic Chemistry and Institute of Biochemistry and Molecular Biology, Lanzhou University, Lanzhou, 730000, P. R. China, and State Key Laboratory of Chiroscience and Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong College of Physics Science and Technology; Yangzhou University; Yangzhou; China Department of BiologyFaculty of Science and Environmental StudyLakehead UniversityThunder BayOntarioCanada Institute of Intelligent Machines, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, P. R. China Beijing Key Laboratory of Development and Quality Control of Ornamental Crops, College of Horticulture, China Agricultural University, Beijing 100193, China State Key Lab for Agro-Biotechnology, Ministry of Agriculture Key Lab of Soil Microbiology, College of Biological Sciences, China Agricultural University, Beijing, 100193, PR China The Centre of Nanoscale Science and Technology and Key Laboratory of Functional Polymer Materials Institute of Polymer Chemistry College of Chemistry and Renewable Energy Conversion and Storage Center (RECAST) Nankai University Tianjin 300071 P. R. China Key Laboratory of Biomedical Polymers, Engineering Research Center of Organosilicon Compounds & Materials, Ministry of Education, College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, Hubei 430072, People’s Republic of China Department of Drug Clinical Trial PLA General Hospital Beijing P. R. China State Key Laboratory of Applied Organic Chemistry and Institute of Biochemistry and Molecular Biology, Lanzhou University, Lanzhou 730000, China; Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Kowloon, Hong Kong OrigiMed, Shanghai, China Department of Critical Care Medicine Cangzhou Central Hospital Cangzhou China State Key Laboratory of Environmentally-Friendly Energy Materials, School of Materials Science and Engineering, Southwest University of Science and Technology, Mianyang 621010, China; Sichuan Lvxin Power Technology Co., Ltd., 88 Hedong Avenue, Shehong 629200, China College of Chemical and Biological Engineering, Taiyuan University of Science and Technology, Taiyuan 030024, China Department of Epidemiology and Health Statistics, Fujian Provincial Key Laboratory of Environment Factors and Cancer, School of Public Health Fujian Medical University Fujian China; Key Laboratory of Ministry of Education for Gastrointestinal Cancer Fujian Medical University Fujian China Department of Chemistry and The RNA Institute, University at Albany, State University of New York, Albany, NY 12222, USA School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, China; School of Life Sciences, Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, China State Key Laboratory of Applied Organic Chemistry, Institute of Biochemistry and Molecular Biology, Lanzhou University, Lanzhou 730000, China; Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Kowloon, Hong Kong Division of Sleep and Circadian Disorders and State Key Laboratory of Cancer Biology and Xijing Hospital of Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute , Boston, Massachusetts , USA 3Michigan Center for Translational Pathology, Ann Arbor, Michigan. Institute of Advanced Synthesis, School of Chemistry and Molecular Engineering, Jiangsu National Synergetic Innovation Center for Advanced Materials, Nanjing Tech University, 30 South Puzhu Road, Nanjing, 211816, People’s Republic of China Luohu District Chronic Disease Hospital , Shenzhen, Guangdong, China Cardiovascular Department, The First Affiliated Hospital of Hebei North University Hebei, China. Department of Medical Oncology Jinling Hospital School of Medicine Nanjing University Nanjing Jiangsu China Shandong Engineering Research Center for Additive Manufacturing Qingdao University of Technology Qingdao 266520 China; Key Lab of Industrial Fluid Energy Conservation and Pollution Control (Qingdao University of Technology) Ministry of Education Qingdao 266520 China Key Laboratory of Pharmaceutical Quality Control of Hebei Province & College of Pharmaceutical Sciences Hebei University Baoding 071002 China; Key Laboratory of Separation Science for Analytical Chemistry, National Chromatographic Research & Analysis Center, Dalian Institute of Chemical Physics Chinese Academy of Sciences Dalian 116023 China School of Pharmaceutical Science Jiangnan University 1800 Lihu Road Wuxi, Jiangsu Province 214122 P. R. China Department of Blood Transfusion, First medical center, Chinese People’s Liberation Army General Hospital, Fu Xing Road, Beijing 100853, China; Reproductive and Genetic Center of National Research Institute for Family Planning, Da Hui Si Road, Beijing 100081, China School of Environmental Science and Engineering; Guangdong University of Technology; Guangzhou China Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China Department of Urology, The First Affiliated Hospital Of Zhengzhou University, Zhengzhou, P.R. China. National Laboratory of Solid State Microstructures & School of Physics; Nanjing University; Nanjing 210093; China Department of Thoracic Surgery Fudan University Shanghai Cancer Center (FUSCC) Shanghai China; Department of Oncology Shanghai Medical College Fudan University Shanghai China Department of Biology York University Toronto Ontario Canada Department of Radiology, Peking University First Hospital, Beijing 100034, China School of Life Science and Technology, ShanghaiTech University, Shanghai, China 201210;; University of Chinese Academy of Sciences, Beijing, China 100049 Department of Radiology The First Affiliated Hospital of Anhui Medical University Hefei China; Research Center of Clinical Medical Imaging Hefei Anhui Province China; Anhui Provincial Institute of Translational Medicine Hefei China Department of Medical Oncology, Jinling Hospital, School of Medicine, Nanjing University Nanjing, Jiangsu Province, China. Department of Biology, Cardivascular and Molecular Research Unit, Lakehead University, Thunder Bay, Ontario, Canada. Institutes of Physical Science and Information Technology, Leibniz Joint Research Center of Materials Sciences, Engineering Laboratory of High-Performance Waterborne Polymer Materials of Anhui Province, Anhui Graphene Engineering Laboratory, Key Laboratory of Structure and Functional Regulation of Hybrid Material (Ministry of Education), Anhui University, Hefei 230601, People’s Republic of China Dalian Institute of Chemical Physics; Chinese Academy of Sciences; Dalian 116023; China; Key Laboratory of Colloid and Interface Chemistry Department of Orthopaedics, Third Affiliated Hospital of Zunyi Medical University (The First People’s Hospital of Zunyi City), Zunyi, China. State Key Laboratory of Chemical Resource Engineering, Institute of Computational Chemistry, College of Chemistry, Beijing University of Chemical Technology, Beijing 100029, China School of Pharmacy, East China University of Science and Technology, Shanghai 200237, P.R. China Department of Orthopedics, Second Affiliated Hospital of Xi'an Jiaotong University, Xi’an, Shaanxi Province, 710004, China Department of Biochemistry and Molecular Biology, Georgia Health Sciences University, Augusta, Georgia; College of Mechanical Engineering, Northeast Electric Power University, Jilin, China Henan Key Laboratory of Crystalline Molecular Functional Materials Henan International Joint Laboratory of Tumor Theranostical Cluster Materials Green Catalysis Center and College of Chemistry Zhengzhou University Zhengzhou Henan 450001 China College of Animal Science, Jilin University, Changchun 130062, China National Center for Nanoscience and Technology, Chinese Academy of Sciences, Beijing 100190, People’s Republic of China Key Lab of Organic Optoelectronics and Molecular Engineering of Ministry of Education Department of Chemistry Tsinghua University Beijing 100084 China State Key Laboratory of Particle Detection and Electronics, University of Science and Technology of China 1 , Hefei 230026, China; Department of Modern Physics, University of Science and Technology of China 2 , Hefei 230026, China Division of Female Pelvic Medicine and Reconstructive Surgery, Department of Obstetrics and Gynecology, Hartford Hospital Hefei National Laboratory for Physical Science at the Microscale, Department of Chemistry, Center for Excellence in Molecular Synthesis, University of Science and Technology of China, Hefei, Anhui 230026, P. R. China Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden The Institute of Pharmacology, Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic, Medical Sciences, Lanzhou University, Lanzhou 730000, China; State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China Liaoning Provincial Key Laboratory of Oral Disease Department of Endodontics School and Hospital of Stomatology China Medical University Shenyang China School of Agriculture Ningxia University Yinchuan China Department of Chemistry; The University of Texas at San Antonio; San Antonio; USA School of Pharmacy Shanghai University of Traditional Chinese Medicine Shanghai China Department of Pathology, School of Basic Medical Science, Fudan University, Shanghai 200032, P.R. China School of Food Science and Engineering, Wuhan Polytechnic University, Wuhan 430023, China Department of Neurology, Second Affiliated Hospital of Harbin Medical University, Harbin, China Division of Sleep and Circadian Disorders, Brigham and Women’s Hospital, Boston, Massachusetts; Division of Sleep Medicine, Harvard Medical School, Boston, Massachusetts Pingshan translational medicine center, Shenzhen Bay Laboratory, Shenzhen, 518118, China School of Life Sciences, Xiamen University, Xiamen. Division of Vascular Surgery National‐Guangdong Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Diseases, The First Affiliated Hospital, Sun Yat‐sen University Guangzhou China Department of Genetic Medicine Weill Cornell Medical College, New York, New York School of Material Science and Technology; Nanjing University of Aeronautics and Astronautics; Nanjing 210016; China Immune Disease InstituteHarvard Medical School Boston MA USA School of Pharmacy, Shanxi Medical University, Taiyuan, China School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, Guangdong 510006, China Department of Toxicology, School of Public Health Jilin University Changchun Jilin Province China Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Department of Population Medicine, Harvard Pilgrim Health Care Institute and Harvard Medical School, Boston, MA, USA School of Nursing and Rehabilitation, Shandong University, Jinan, Shandong, China Department of Plant Protection, College of Plant Sciences, Jilin University, Changchun 130062, China Department of General Surgery The First Affiliated Hospital of Anhui Medical University Hefei China Center for Developmental Biology, College of Life Sciences, Wuhan University, Wuhan 430072, China. Hunan Engineering Technology Research Center for Comprehensive Development and Utilization of Biomass Resources, Hunan University of Science and Engineering, Yongzhou 425100, China 1Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas. Emergency Department Tianjin Medical University General Hospital Tianjin China Department of General Surgery, Department of Pathology, Department of Ultrasound, Xiang’an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen 361101, China; Organ Transplantation Institute of Xiamen University, Fujian Provincial Key Laboratory of Organ and Tissue Regeneration, Xiamen Key Laboratory of Regeneration Medicine, School of Medicine, Xiamen University, Xiamen 361101, China Department of Neurosurgery, Union Hospital of Fujian Medical University, Fujian Institute of Neurosurgery, Fuzhou, Fujian 350001, P.R. China School of Food and Biological Engineering, Hefei University of Technology, Hefei, People’s Republic of China Department of Neurobiology Howard Hughes Medical Institute Duke University Medical Center Durham North Carolina 27710; Computational Biology and Bioinformatics Program Institute for Genome Science and Policy Duke University Durham North Carolina 27710; Beijing Prosperous Biopharm Beijing 100085 China Anhui Key Laboratory of Tissue Transplantation, Bengbu Medical College, Bengbu 233004, P.R. China Department of Dermatology, First Medical Center of Chinese PLA General Hospital, Beijing The Centre of Nanoscale Science and Technology and Key Laboratory of Functional Polymer Materials Institute of Polymer Chemistry College of Chemistry Nankai University Tianjin 300071 China Department of Obstetrics and Gynaecology, Monash University, Melbourne, VIC, Australia. Department of Biochemistry and Siebens-Drake Medical Research Institute, Schulich School of Medicine and Dentistry, Western University, London, Ontario N6A 5C1, Canada Rehabilitation Centre of Otolaryngology—Head and Neck, Beijing Rehabilitation Hospital, Capital Medical University, Beijing, P.R. China State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing 211816, China; College of Food Science and Light Industry, Nanjing Tech University, Nanjing 211816, China Cancer Center, Department of Oncology, First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, China. Department of Obstetrics and Gynaecology, Monash University, Clayton, Victoria, Australia r.wang@monash.edu. Key Laboratory of Biochemistry and Molecular Biology in Universities of Shandong Province Weifang University Weifang 261061 China. E-mail: 13075308745@163.com. School of Materials and Energy, University of Electronic Science and Technology of China, 2006 Xiyuan Avenue, West High-Tech Zone, Chengdu 611731, China State Key Laboratory of Solid Lubrication Lanzhou Institute of Chemical Physics Chinese Academy of Sciences Lanzhou 730000 China; Laboratory of Advanced Materials and Green Manufacturing Yantai 264000 Shandong China School of Space and Environment, Beihang University, Beijing 100191, China Shenshan Medical Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Shanwei, Guangdong, China. Breast Tumor Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China. Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangzhou, Guangdong, China. Department of Chemistry, Collaborative Innovation Center of Chemistry for Energy Materials, State Key Laboratory of Molecular Engineering of Polymers, Shanghai Key Lab of Molecular Catalysis and Innovative Materials, Fudan University, Shanghai 200433, P.R. China Department of Urology, The First Affiliated Hospital of Kunming Medical University, Kunming 650032, China; The First Affiliated Hospital of Kunming Medical University, Yunnan Province Clinical Research Center for Chronic Kidney Disease, Kunming 650032, China Aging Research Center Department of Neurobiology Care Sciences and Society Karolinska Institutet and Stockholm University Stockholm Sweden Northeast Electric Power University, Jilin 132012, China Key Laboratory of Preclinical Study for New Drugs of Gansu Province, Lanzhou University, Lan Zhou, Gansu Province, China *Molecular Biology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892; Surgical Oncology, Hangzhou Cancer Hospital, Hangzhou City, Zhejiang Province, China From the Department of Neurobiology (R.W., E.J.L., G.K., L.B., L.F., C.Q.), Care Sciences and Society, Aging Research Center, Karolinska Institutet and Stockholm University; Division of Radiology (A.L.), Department of Clinical Science, Intervention and Technology, Karolinska University Hospital at Huddinge; Department of Neuroradiology (A.L.), Karolinska University Hospital, Stockholm; and Stockholm Gerontology Research Center (L.F.), Stockholm, Sweden. Center for Supramolecular Chemistry & Catalysis and Department of Chemistry, College of Science, Shanghai University, Shanghai 200444, China School of Materials Design & Engineering, Beijing Institute of Fashion Technology, Beijing 100029, China Faculty of Geoscience and Environmental Engineering; Southwest Jiaotong University; Chengdu; P. R. China Zhengzhou University People's Hospital, Henan Eye Hospital and Henan Eye Institute, Henan Provincial People's Hospital, Zhengzhou, Henan, China; Academy of Medical Sciences of Zhengzhou University, Zhengzhou, Henan, China Department of Digestive Diseases, Huashan Hospital, Fudan University, Shanghai, China.; Department of Immunology of Shanghai Medical School and Institutes of Biomedical Sciences, Fudan University, Shanghai, China. Shenzhen Luohu Center for Chronic Disease Control, Shenzhen, China. State Key Laboratory of Advanced Processing and Recycling of Non-ferrous Metals, School of Materials Science and Engineering, Lanzhou University of Technology, Lanzhou, Gansu 730050, China Physiology College of Medicine, University of Saskatchewan Saskatoon Saskatchewan Canada Department of Biology, York University, Toronto, ON M3J 1P3, Canada; Department of Chemistry Harbin Institute of Technology Harbin 150001 China College of Biotechnology and Pharmaceutical Engineering, Nanjing University of Technology, 30 Puzhunan Road, Nanjing 211816, People’s Republic of China School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China School of Chemistry & Chemical Technology, State Key Laboratory for Metal-Composite Materials, Shanghai Jiao Tong University, Shanghai 200240, People’s Republic of China Key Laboratory of Preclinical Study for New Drugs of Gansu Province, State Key Laboratory of Applied Organic Chemistry and Institute of Biochemistry and Molecular Biology, Lanzhou University, Lanzhou, 730000 China; State Key Laboratory of Chiroscience, and Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Kowloon, Hong Kong Department of Medical Oncology Jinling Hospital School of Medicine Nanjing University Nanjing China Michigan State University Key Laboratory of Preclinical Study for New Drugs of Gansu Province Lanzhou University Lanzhou 730000 P. R. China Department of Oncology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China; Department of Gastroenterology, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200071, China Jinling Hospital; Department of Orthopaedics; State Key Laboratory of Pharmaceutical Biotechnology; Nanjing University; Nanjing, China State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu, Sichuan, China; College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China Chongqing Key Laboratory of Catalysis and Functional Organic Molecules; College of Environmental and Biological Engineering; Chongqing Technology and Business University; Chongqing, China Department of Radiology and Radiological Science, Medical University of South Carolina, Ashley River Tower, MSC 226, 25 Courtenay Dr, Charleston, SC 29425.; Department of Radiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China. Department of Chemistry, Laboratory of Advanced Materials, State Key Laboratory of Molecular Engineering of Polymers, Fudan University, Shanghai 200433, P. R. China State Key Laboratory of Structural Chemistry; Fujian Institute of Research on the Structure of Matter; Chinese Academy of Sciences; Fuzhou 350002; China Key Laboratory of UV-Emitting Materials and Technology of Chinese Ministry of Education, Northeast Normal University, Changchun 130024, China Department of Thoracic Surgery, Shanghai Chest Hospital, Shanghai Jiao Tong University, No. 241 West Huaihai Road, Shanghai 200030, China Department of Medical Physiology College of Medicine Texas A&M University Temple USA; Yangpu District Central Hospital Tongji University Shanghai China Department of Pancreatic Surgery, West China Hospital, Sichuan University, Chengdu, China School of Physics, Henan Key Laboratory of Photovoltaic Materials, Henan Normal University, Xinxiang 453007, China Department of Radiology Peking University First Hospital Beijing PR China College of Geography and Environmental Science, Zhejiang Normal University, Jinhua, China Department of Sport Injury & Arthroscopy, The First Affiliated Hospital of Anhui Medical University, Anhui, China Division of Vascular Surgery, The First Affiliated Hospital, Sun Yat‑sen University, Guangzhou, Guangdong 510080, P.R. China State Key Lab of CAD&CG Zhejiang University Hangzhou Zhejiang China School of Advanced Materials, Peking University Shenzhen Graduate School, Shenzhen 518055, China Department of Population Medicine, Harvard Pilgrim Health Care Institute, Harvard Medical School, Boston, Massachusetts; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts Henan Engineering Technology Research Center for Modern Preparation of TCM and Clinical Application Luohe Henan 462002 China Clinical and Research Center for Infectious Diseases, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China; Beijing Key Laboratory for HIV/AIDS Research, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China Department of Cardiovascular Medicine, The First Affiliated Hospital of Hebei North University, Zhangjiakou, Hebei, China Department of Electrical & Electronic Engineering, Southern University of Science and Technology, Shenzhen, 518055, China Department of Oncology, The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou, Guangdong, China. College of Food Science Southwest University Chongqing China; Chongqing Collaborative Innovation Center for Functional Food Chongqing University of Education Chongqing China Department of Orthopaedics Jinling Hospital School of Medicine Nanjing University China Institute of Functional Materials and Molecular Imaging, Key Laboratory of Emergency and Trauma, Ministry of Education, Key Laboratory of Hainan Trauma and Disaster Rescue, College of Clinical Medicine, College of Emergency and Trauma, Hainan Medical University, Haikou 571199, China School of Nursing, Shandong University, Jinan, Shandong, China Enshi Tobacco Company of Hubei Province, Enshi, China The Centre of Nanoscale Science and Technology and Key Laboratory of Functional Polymer Materials, Institute of Polymer Chemistry, College of Chemistry and Renewable Energy Conversion and Storage Center (RECAST) Nankai University Tianjin 300071 China Department of Computer Science, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA Program of Molecular Pharmacology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, United States School of Mechanical Engineering, Guilin University of Aerospace Technology, Guilin 541004, China College of Chemistry & Chemical Engineering, Shaanxi University of Science & Technology, Xi'an, Shaanxi 710021, PR China Luohu District Chronic Disease Hospital, Shenzhen, Guangdong, China (R.W.). Department of Biology, Lakehead University, Thunder Bay, ON, Canada P7B 5E1; Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, New York 10029 Department of Nephrology, Chinese PLA General Hospital, Beijing, China. Chongqing Collaborative Innovation Center for Functional Food, Chongqing Engineering Research Center of Functional Food, Chongqing Engineering Laboratory for Research and Development of Functional Food, Chongqing University of Education, Chongqing 400067, China; College of Biological and Chemical Engineering, Chongqing University of Education, Chongqing 400067, China Institute of Crop Sciences, Chinese Academy of Agricultural Sciences, Beijing, P. R. China China Food Flavor and Nutrition Health Innovation Center, Beijing Technology and Business University, Beijing 100048, China Department of Pathology and Laboratory Medicine, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA Biodesign Center for Bioelectronics and Biosensors, Arizona State University, Tempe, Arizona 85287, USA; State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, 2 Sipailou, Nanjing 210096, China Key Laboratory of Flexible Electronics (KLOFE), Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing Tech University (NanjingTech), 30 South Puzhu Road, Nanjing 211816, China Department of Endocrinology, First Hospital of Qinhuangdao, Qinhuangdao, China Institute for Structure and Function and Department of Physics Chongqing University Chongqing 400044 China Department of Population Medicine, Harvard Pilgrim Health Care Institute and Harvard Medical School , Boston, Massachusetts; Department of Biostatistics, Harvard T. H. Chan School of Public Health , Boston, Massachusetts Department of Anesthesiology, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, 710061, China School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, 110016, Peopleʼs Republic of China, State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Kunming, 650204, Yunnan, Peopleʼs Republic of China, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, 110016, Peopleʼs Republic of China, and Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029-6547 Department of Biomedical Sciences, College of Veterinary Medicine and Life Sciences, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong, China Department of Medical Oncology, First Affiliated Hospital of Bengbu Medical College, Bengbu 233004, Anhui, China State Key Laboratory of Cancer Biology & Xijing Hospital of Digestive Diseases Fourth Military Medical University No. 127 West Changle Road Xi'an 710032 Shaanxi Province China Institute of Atomic and Molecular Physics; Jilin University; Changchun 130012; China; Jilin Provincial Key Laboratory of Applied Atomic and Molecular Spectroscopy (Jilin University) Department of Biochemistry and Molecular Biology, Medical College of Georgia, 1120 15th Street, CB2516, Augusta, GA 30912, USA. Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Healthcare Institute, Boston, Massachusetts School of Computer, National University of Defense Technology, Changsha 410073, China Key Laboratory of Cell Proliferation and Regulation Biology, Ministry of Education, Beijing Normal University, Beijing, China. Department of Mathematics, Michigan State University, East Lansing, Mich., U.S.A. From the Vascular Medicine Unit, School of Life and Health Sciences, Aston University, Aston Triangle, Birmingham, United Kingdom (K.W., S.A., M.C., A.A.); Gustav Born Centre for Vascular Biology, BHF Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, United Kingdom (K.W., S.A., M.C., J.R., T.K., J.B., M.R.M., M.C., P.W.F.H., A.A.); Department of Maternal-Fetal Medicine, Hospital Clinic-IDIBAPS, University of Barcelona, Spain (F.C., E.G.); Lakehead University, Thunder Bay,... Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences; Lanzhou University; Lanzhou 730000 China Authors' Affiliations: Departments of 1Pharmacology and 2Chemical Engineering, Shenyang Pharmaceutical University, Shenyang; 3School of Pharmaceutical Sciences, Shandong University, Jinan, Shandong, China; and 4The Division of Hematology/Oncology, Department of Medicine, The Tisch Cancer Institute, Mount Sinai School of Medicine, New York, New York Department of Ultrasound, Jilin Cancer Hospital, Changchun, Jilin 130021, P.R. China Department of General Surgery (Hepatopancreatobiliary Surgery; Academician (Expert) Workstation of Sichuan Province, Metabolic Hepatobiliary and Pancreatic Diseases Key Laboratory of Luzhou City, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan Province, China Department of Neurology The Third Affiliated Hospital of Sun Yat‐Sen University Guangzhou Guangdong China Department of Civil and Environmental Engineering, Princeton University, Princeton 08544, New Jersey, United States; Center for Mid-Infrared Technologies for Health and the Environmental, NSF-ERC, Princeton, New Jersey 08540, United States Department of Biochemistry and Molecular Biology, Second Military Medical University, Shanghai, 200433, China Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, Frontiers Science Center for Materiobiology and Dynamic Chemistry, Institute of Fine Chemicals, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai 200237, P. R. China. Key Laboratory of Advanced Materials (MOE), School of Materials Science and Engineering, Tsinghua University, Beijing, China Department of Biology, Lakehead University, Thunder Bay, Ontario, Canada;; Cardiovascular and Metabolic Research Unit, Laurentian University, Sudbury, Ontario, Canada;; Department of Biology, Laurentian University, Sudbury, Ontario, Canada Department of Cardiovascular Medicine, The First Affiliated Hospital of Hebei North University, Zhangjiakou City, Hebei, China School of Pharmacy Anhui University of Chinese Medicine Hefei China; Department of Pharmacy Anhui Academy of Chinese Medicine Hefei China Department of Obstetrics and Gynecology, Guizhou Medical University, Guiyang 550004, China. Hefei National Laboratory for Physical Science at the Microscale and Department of Chemistry, University of Science and Technology of China, Center for Excellence in Molecular Synthesis of CAS, Hefei, Anhui 230026, P. R. China Division of Nanomaterials and Chemistry, Hefei National Laboratory for Physical Sciences at the Microscale, Institute of Energy, Hefei Comprehensive National Science Center, CAS Center for Excellence in Nanoscience, Department of Chemistry, Institute of Biomimetic Materials and Chemistry, Anhui Engineering Laboratory of Biomimetic Materials, University of Science and Technology of China, Hefei 230026, China Guangdong Provincial Key Laboratory of Biocomputing, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences; Guangzhou Medical University, Guangzhou, China Department of Thoracic Surgery, Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050011, P.R. China Department of Orthopaedics, China-Japan Union Hospital of Jilin University, Changchun, Jilin, China. Claude Pepper Institute and Department of Biomedical and Chemical Engineering and Sciences, Florida Institute of Technology The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China 2Department of Ophthalmology, Massachusetts Eye and Ear Infirmary/Schepens Eye Research Institute, Harvard Medical School, Boston, Massachusetts, United States Institute of Theoretical and Computational Chemistry; Shaanxi Key Laboratory of Catalysis; School of Chemical & Environment Science; Shaanxi University of Technology; Hanzhong Pingshan Translational Medicine Center, Shenzhen Bay Laboratory, Shenzhen, 518118, P. R. China 1Department of Endocrinology, The First Hospital of Qinhuangdao, Qinhuangdao, China Cardiovascular and Metabolic Research Unit, Laurentian University, Sudbury, Canada. Anhui Key Laboratory of Tissue Transplantation First Affiliated Hospital of Bengbu Medical College Anhui People's Republic of China Department of Biology, Lakehead University, Thunder Bay, ON, Canada P7B 5E1; and College of Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot 010018, China Hefei Municipal Health Commission, Hefei, Anhui, China; Department of Gynecology and Obstetrics, Maternity and Child Healthcare Hospital Affiliated to Anhui Medical University, Anhui Province Maternity and Child Healthcare Hospital, Hefei, Anhui, China Key Laboratory of Cell Proliferation and Regulation of Ministry of Education Beijing Normal University Beijing China College of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou, Zhejiang 310058, People’s Republic of China; Key Laboratory of On Site Processing Equipment for Agricultural Products, Ministry of Agriculture, Hangzhou, Zhejiang 310058, People’s Republic of China Department of Medical Oncology, School of Medicine, Jinling Hospital Nanjing University Nanjing China Beth Israel Deaconess Medical Center; Harvard Medical School affiliate; Boston MA USA; Harvard Medical School; Boston MA USA Pingshan Translational Medicine Center, Shenzhen Bay Laboratory, Lan Jing Road No. 16, Pingshan, Shenzhen 518118, China State Key Laboratory of Solid Lubrication Lanzhou Institute of Chemical Physics Chinese Academy of Sciences Lanzhou 730000 China; Yantai Zhongke Research Institute of Advanced Materials and Green Chemical Engineering Shandong Laboratory of Yantai Advanced Materials and Green Manufacture Yantai 264006 China Department of Biostatistics Harvard TH Chan School of Public Health Boston Massachusetts USA; Department of Population Medicine Harvard Medical School and Harvard Pilgrim Health Care Institute Boston Massachusetts USA Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Institute of Biochemistry and Molecular Biology, School of Life Sciences, Lanzhou University, Lanzhou, Gansu Province, People's Republic of China Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Institute of Biochemistry and Molecular Biology, School of Life Sciences, Lanzhou University, Lanzhou 730000, P. R. China Center of Infectious Diseases, Beijing You'an Hospital, Capital Medical University, Beijing 100069, China A State Key Laboratory of Power Systems Department of Electrical Engineering Tsinghua University Beijing 100084 China West China-Washington Mitochondria and Metabolism Centre, West China School of Medicine/West China Hospital of Sichuan University Chengdu 610041, China. Department of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China; Hubei Province Clinical Research Center for Medical Imaging, Wuhan 430022, China; Hubei Province Key Laboratory of Molecular Imaging, Wuhan 430022, China Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing 100850, China. Key Laboratory of Advanced Materials (MOE), School of Materials Science and Engineering, Tsinghua University, Beijing 100084, China College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, 210095, China National Center for Nanoscience and Technology Beijing 100190 China Cardiovascular and Metabolic Research Unit Laurentian University ON P3E 2C6 Canada School of Pharmaceutical Sciences Sun Yat‐sen University Guangzhou China; Key Laboratory of Preclinical Study for New Drugs of Gansu Province School of Basic Medical Sciences Lanzhou University Lanzhou China Henan Key Laboratory of Big Data Analysis and Processing, School of Computer and Information Engineering, Henan University, Kaifeng 475001, China Department of Ophthalmology, The First Hospital of Xi'an, Xi'an, Shaanxi, 710002, China. Division of Nanomaterials and Chemistry, Hefei National Laboratory for Physical Sciences at the Microscale, CAS Center for Excellence in Nanoscience, Department of Chemistry, Institute of Biomimetic Materials and Chemistry, University of Science and Technology of China, Hefei 230026, China International School of Microelectronics, Dongguan University of Technology, Dongguan, Guangdong, 523808, China; Faculty of Physics & Electronic Science, Hubei University, Wuhan, 430062, China Department of Critical Care Medicine, Cangzhou Central Hospital, Cangzhou, Hebei 061001, P.R. China Key Laboratory of Preclinical Study for New Drugs of Gansu Province, State Key Laboratory of Applied Organic Chemistry and Institute of Biochemistry and Molecular Biology, Lanzhou University Department of Neurosurgery, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, Liaoning 121001, P.R. China 1Division of Hematology/Oncology, Department of Medicine, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York City, New York. Faculty of Psychology, Southwest University, Chongqing, China Department of Medical Oncology, First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233004, P.R. China Key Laboratory of Synthetic Biology, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200032, People's Republic of China Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA USA. Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA. Department of Clinical Laboratory Anhui Provincial Hospital Affiliated to Anhui Medical University Hefei Anhui China Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China Shanxi University of Chinese Medicine Taiyuan 030619, China. Jiangsu Key Laboratory for Microbes and Microbial Functional Genomics, Jiangsu Engineering and Technology Research Center for Industrialization of Microbial Resources, College of Life Science, Nanjing Normal University, Nanjing, People’s Republic of China Department of Chemistry, Northeast Normal University, Changchun 130024, China State Key Lab of CAD&CG, Zhejiang University, Hangzhou, Zhejiang 310058, China Program of Pharmacology, Weill Graduate School of Medical Science, Cornell University, New York, New York 10021, United States From the Division of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (Y.Y.Z., S.J., R.W., N.G., S.R.); Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA (R.W.) Shaanxi Key Laboratory of Catalysis; School of Chemical & Environment Science; Shaanxi Sci-Tech University; Hanzhong 723001; China Department of Chemistry; University at Albany; State University of New York; Albany; USA Department of Cardiology Zhongshan Hospital Fudan University Shanghai Institute of Cardiovascular Diseases 180 Fenglin Road, Xuhui District Shanghai 20032 P. R. China School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225002, People’s Republic of China Retina Consultants of Houston, Houston, Texas; and School of Marine Science and Technology; Harbin Institute of Technology at Weihai; Shandong 264209, China National Laboratory of Solid State Microstructures and Department of Physics, Nanjing University, Nanjing 210093, China; Collaborative Innovation Center for Advanced Microstructures, Nanjing 210093, China Zhenjiang Key Laboratory of Medical Immunology Department of Laboratory Medicine Affiliated Hospital of Jiangsu University Zhenjiang China Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.; Harvard Medical School, Boston, Massachusetts. Department of Biology, Lakehead University, Thunder Bay, Ontario, Canada.; Department of Pathophysiology, Harbin Medical University, Harbin, P.R. China. Department of Medical Oncology Jinling Hospital, Medical School of Nanjing University Nanjing, Jiangsu Province People’s Republic of China School of Data Science and Artificial Intelligence, Wenzhou University of Technology , 325000 Wenzhou , China Key Laboratory of Agricultural Environmental Microbiology, Ministry of Agriculture, College of Life Sciences, Nanjing Agricultural University, Nanjing, China China‐US (Henan) Hormel Cancer Institute Zhengzhou China Department of Toxicology, School of Public Health, Jilin University, Changchun 130021, Jilin, China. National Institute for Nutrition and Health, China CDC, Beijing 100050, China; Key Laboratory of Trace Element Nutrition of National Health Commission, Beijing 100050, China Department of Materials Science and Engineering and California Nano Systems Institute University of California Los Angeles CA 90095 USA State Key Laboratory of Materials-Oriented Chemical Engineering; NanjingTech University; Nanjing 210009; P. R. China Key Laboratory of Infection and Immunity of CAS Institute of Biophysics, Chinese Academy of Sciences, Beijing, People’s Republic of China College of Forensic Medicine, Xi’an Jiaotong University Health Science Center, Xi’an 710061, China; The Key Laboratory of Health Ministry for Forensic Science, Xi’an Jiaotong University, Xi’an 710061, China; National Biosafety Evidence Foundation, Bio-Evidence Sciences Academy, Western China Science and Technology Innovation Harbor, Xi’an Jiaotong University, Xi’an 710115, China College of Food Science Northeast Agricultural University No. 59 Mucai Street, Xiangfang District Harbin 150030 Heilongjiang China Department of Quality Control, Tanggu Blood Center, Tianjin, P.R. China; 1Department of Surgical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas. Department of Radiology and Biomedical Imaging Yale University New Haven Connecticut USA; Department of Engineering Physics Tsinghua University Beijing China Laboratory of Molecular Neuropathology, Jiangsu Key Laboratory of Neuropsychiatric Diseases & Department of Pharmacology, College of Pharmaceutical Sciences, Soochow University, Suzhou, 215123, China. Center for Infectious Diseases, Beijing You'an Hospital, Capital Medical University, Beijing, China. 1Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, Michigan.; 2Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan. The Third Clinical Medical College, Xinxiang Medical University, Xinxiang 453003, China Livestock and Poultry Multi-Omics Key Laboratory of Ministry of Agriculture and Rural Affairs, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China; Animal Breeding and Genetics Key Laboratory of Sichuan Province, Sichuan Animal Science Academy, Chengdu 610066, China Department of Gastroenterology West China Hospital, Sichuan University Chengdu China College of Life Science, and Key Laboratory of Small Functional Organic Molecule, Ministry of Education, Jiangxi Normal University, Nanchang, Jiangxi 330022, People’s Republic of China Department of Neurology The Second Clinical College of Harbin Medical University Harbin China Departments of Medicine and Neurology, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts; Department of Population Medicine, Harvard Pilgrim Health Care Institute and Harvard Medical School, Boston, Massachusetts; Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, Massachusetts From the Botswana–Harvard AIDS Institute Partnership (J. Makhema, T.G., M.M., E.K., U.C., K. Manyake, A.M.M., S.V.S., R. Letlhogile, K. Mukokomani, E.W., S.M., K.M.P., S.L.D.-P., C.K., S.G., H.B., L.O., O.J., E.T.T., M.E., S.L.), the Botswana Ministry of Health and Wellness (R. Lebelonyane, S.E.-H.), and the Centers for Disease Control and Prevention (M.G.A., W.A., T.M., L.A.M., M.R.), Gaborone, Botswana; Harvard T.H. Chan School of Public Health (K.E.W., M.P.H., S.M., K.M.P., S.L.D.-P., V.N., S.G., R.L... School of Pharmacy Shanghai University of Traditional Chinese Medicine Shanghai P. R. China Prosperous Biopharma Co. Ltd Beijing China iHuman Institute and School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China. Division of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, State Key Laboratory for Oncogenes and Related Genes, Renji Hospital, School of Medicine, Shanghai JiaoTong University; Shanghai Institute of Digestive Disease;145 Middle Shandong Road, Shanghai, China Department of Sports Biomechanics, College of Sports Human Science, Beijing Sport University, Beijing 100084, China State Key Laboratory of Bioengineering Reactor, Shanghai Key Laboratory of New Drug Design, and Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science & Technology, 130 Meilong Road, Shanghai 200237, China School of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin, People’s Republic of China; Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, China; State Key Laboratory of Chiroscience, Hong Kong, Polytechnic University, Hong Kong, China State Key Laboratory of Materials‐Oriented Chemical Engineering Nanjing Tech University 30 Puzhu South Road Nanjing 211816 P. R. China School of Population Health, University of Auckland, Auckland, New Zealand. Third Military Medical University Laboratory of Nuclear Receptors and Cancer Research, Basic Medical Research Center, School of Medicine Nantong University Nantong Jiangsu China; Key Laboratory of Microenvironment and Cancer Translational Medicine, School of Medicine Nantong University, Nantong Jiangsu China Department of Hematology, the Tumor Center, QiLu Hospital of Shandong University, Jinan 250012, China. State Key Laboratory of Multiphase Complex Systems, Institute of Process Engineering, Chinese Academy of Sciences, Beijing100190, China School of Life Science, Beijing Institute of Technology, Beijing, China Key Laboratory of Emergency and Trauma Ministry of Education Key Laboratory of Hainan Trauma and Disaster Rescue The First Affiliated Hospital of Hainan Medical University Institute of Functional Materials and Molecular Imaging College of Emergency and Trauma Hainan Medical University Haikou 571199 China Department of Gastroenterology, Nursing Section, West China Hospital Sichuan University Chengdu China State Key Laboratory of Agricultural Microbiology, College of Life Science and Technology, Huazhong Agricultural University, Wuhan 430070, PR China; Tobacco Company of Enshi, Hubei Province, Enshi, 445000 Hubei, PR China Department of Neurology, West China Hospital, Sichuan University/ West China School of Nursing, Sichuan University, Chengdu, People’s Republic of China Jinming Yu Academician Workstation of Oncology, Clinical Research Center, Affiliated Hospital of Weifang Medical University, Weifang 261031, China; Department of Oncology, Affiliated Hospital of Weifang Medical University, Weifang 261031, China Department of Cardiology, The First Affiliated Hospital of Hebei North University, Zhangjiakou, China School of Software, Yunnan University, Kunming 650091, China Department of Electronic Engineering; Xiamen University; Xiamen 361005; China Department of Finance, School of Economics Peking University Beijing China College of Basic Medical Sciences, Shenyang Medical College, Shenyang 110034, China Section of Marine Ecology and Biotechnology, Division of Life Science, The Hong Kong University of Science and Technology (HKUST), Clear Water Bay, Kowloon, Hong Kong College of Chemistry, Chemical and Environmental Engineering; Laboratory of Fiber Materials and Modern Textile, the Growing Base for State Key Laboratory, Qingdao University, Qingdao 266071, China Shanghai Key Laboratory of New Drug Design; School of Pharmacy; East China University of Science & Technology; Shanghai 200237; P. R. China Department of Thoracic Surgery, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China State Key Laboratory of Crop Genetics and Germplasm Enhancement, College of Agriculture, Nanjing Agricultural University , Nanjing 210095, China School of Mechanical Engineering, Northeast Electric Power University, Jilin 132012, China School of Public Health, NHC Key Laboratory of Radiobiology, Jilin University, Changchun, Jilin, China Department of Respiratory and Critical Care Medicine, Tianjin Medical University General Hospital, Tianjin 300052, China Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou 510405, China Department of Cardiology, Shenzhen University General Hospital, Shenzhen, China College of Basic Medical Sciences Shenyang Medical College Shenyang 110034 P. R. China Key Laboratory of Preclinical Study for New Drugs of Gansu Province, and Institute of Physiology, School of Basic Medical Sciences, Lanzhou University, 199 Donggang West Road, Lanzhou, 730000, PR China State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Oral Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China Department of Medical Oncology, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, China. Key Lab. of Advanced Technology for Materials of Education Ministry, Southwest Jiaotong University, Chengdu 610031, China; School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China Department of Pharmacy; The First Hospital of Jilin University; Changchun; China From the Solomon H. Snyder Department of Neuroscience (A.K.M., S.K.G., F.K.G., R.K.B., S.H.S.) and the Department of Anesthesiology/Critical Care Medicine (G.S., J.S., S.M.J., A.K.B., V.M.B., D.E.B.) Johns Hopkins University School of Medicine, Baltimore, MD; the Department of Biology, Lakehead University, Thunder Bay, Ontario, Canada (R.W.); and the Department of Biophysics and Biophysical Chemistry (M.A.), the Department of Biomedical Engineering (D.E.B.), the Departments of Pharmacology and... Key Laboratory of Preclinical Study for New Drugs of Gansu Province; School of Basic Medical Sciences; Lanzhou University; Lanzhou 730000; China Chinese Academy of Sciences Center for Excellence in Nanoscience, Chinese Academy of Sciences Key Laboratory of Nanosystem and Hierarchical Fabrication, National Center for Nanoscience and Technology, Beijing 100190, China;; University of Chinese Academy of Sciences, Beijing 100049, China Department of Chemistry, The Chinese University of Hong Kong, Hong Kong, SAR, China. Division of Biomaterials, National Institutes for Food and Drug Control, Beijing, China. Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Institute of Biochemistry and Molecular Biology, State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, China 730000 State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, 130012 Changchun, China Beijing Key Laboratory of Fuels Cleaning and Advanced Catalytic Emission Reduction Technology/College of Chemical Engineering, Beijing Institute of Petrochemical Technology, Beijing 102617, Beijing, China Key Laboratory of Research and Development of New Medical Materials of Guangdong Medical University; School of Pharmacy; Guangdong Medical University; Dongguan; China Institute of Chinese Medicinal Materials,Nanjing Agricultural University Nanjing 210095,China. Key Laboratory of Advanced Energy Materials Chemistry (Ministry of Education), Renewable Energy Conversion and Storage Center, Haihe Laboratory of Sustainable Chemical Transformations, College of Chemistry, Nankai University, Tianjin 300071, People's Republic of China Department of Health Statistics Naval Medical University Shanghai China Department of Diagnostic Radiology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei 430071, P.R. China Agro-Environmental Protection Institute, Ministry of Agriculture and Rural Affairs, Tianjin 300191, China. Chengdu University of Traditional Chinese Medicine, Chengdu, China Key Laboratory of Synthetic Biology Institute of Plant Physiology and Ecology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 200032 China; University of Chinese Academy of Sciences Beijing 100049 China Department of Epidemiology and Health Statistics Fujian Provincial Key Laboratory of Environment Factors and Cancer School of Public Health Fujian Medical University Fuzhou China; Key Laboratory of Ministry of Education for Gastrointestinal Cancer Fujian Medical University Fuzhou China Department of Neurosurgery, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China State Key Laboratory of Heavy Oil Processing College of Chemistry and Chemical Engineering College of New Energy China University of Petroleum (East China) Qingdao 266580 China Department of Electronic Engineering, Xiamen University, Xiamen 361005, China Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA Institute of Pharmacology Toxicology and Biochemical Pharmaceutics Zhejiang University Hangzhou China; Department of Pharmacology Ningxia Medical University Yinchuan China Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Institute of Biochemistry and Molecular Biology, School of Life Sciences, Lanzhou University, Lanzhou, 730000, P. R. China Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Hebei University Department of Orthopaedic Surgery Tianjin Medical University General Hospital Tianjin China Robinson Research Institute The University of Adelaide Adelaide South Australia Australia Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian 350002, P. R. China; University of Chinese Academy of Sciences, Beijing 100049, P. R. China Department of Oncology, Shanghai General Hospital of Nanjing Medical University, Shanghai 201620, P.R. China Changchun Institute of Applied Chemistry Chinese Academy of Sciences Renmin Street 5625 Changchun 130022 Jilin China College of Biomass Science and Engineering, Sichuan University, Chengdu 610065, People’s Republic of China National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Beijing 100005, China. Green Catalysis Center, and College of Chemistry; Zhengzhou University; Zhengzhou 450001; China School of Education, University of Delaware. Department of Population Medicine, Harvard Pilgrim Health Care Institute and Harvard Medical School, Boston; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston Key Laboratory of Preclinical Study for New Drugs of Gansu Province School of Basic Medical Sciences Lanzhou University Lanzhou 730000 China; State Key Laboratory of Chiroscience Department of Applied Biology and Chemical Technology The Hong Kong Polytechnic University, Kowloon Hong Kong P. R. China Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Medicine, State Key Laboratory of Applied Organic Chemistry, and Institute of Biochemistry and Molecular Biology, Lanzhou University, Lanzhou 730000, P. R. China Hubei Province Key Laboratory of Biotechnology of Chinese Traditional Medicine, Hubei Collaborative Innovation Center for Green Transformation of Bio-resources, National & Local Joint Engineering Research Center of High-throughput Drug Screening Technology, State Key Laboratory of Biocatalysis and Enzyme Engineering, School of Life Sciences, Hubei University, Wuhan 430062, Hubei, China. Key Laboratory of Storage and Processing of Plant Agro‐Products, College of Biological Science and Engineering North Minzu University Yinchuan China Karlsruhe Institute of Technology, Institute for Meteorology and Climate Research (IMK-IFU), 82467 Garmisch-Partenkirchen, Germany; Institute of Atmospheric Physics, Chinese Academy of Sciences, Beijing 100029, China School of Biomedical Engineering The Province and Ministry Co‐Sponsored Collaborative Innovation Center for Medical Epigenetics Intensive Care Unit of the Second Hospital Tianjin Medical University No. 22 Qixiangtai Road, Heping District Tianjin 300070 China Department of Computer Science, Dartmouth College School of Ophthalmology & Optometry; Eye Hospital; Wenzhou Medical University; Wenzhou 325027; China Department of Obstetrics and Gynecology, Guangdong Provincial Key Laboratory for Major Obstetric Diseases; Guangdong Province Clinical Research Center for Obstetrics and Gynecology; Guangdong-Hong Kong-Macoa Greater Bay Area Higher Educaiton Joint Laboratory of Maternal-Fetal Medicine, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China Division of Life Science, The Hong Kong University of Science and Technology (HKUST), Clear Water Bay, Kowloon, Hong Kong Sanya Nanfan Research Institute, Hainan University, Sanya 572025, China; School of Tropical Crops, Hainan University, Haikou 570288, China Department of Dermatology, Peking University First Hospital, Beijing, China; National Clinical Research Center for Skin and Immune Diseases, Beijing, China; Beijing Key Laboratory of Molecular Diagnosis on Dermatoses, Beijing, China Psychiatric Department, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China; Yunnan Clinical Research Center for Mental Health, Kunming, Yunnan, China State Key Laboratory for Agrobiotechnology, Key Laboratory of Crop Heterosis and Utilization (MOE) Beijing Key Laboratory of Crop Genetic Improvement China Agricultural University Beijing China; National Plant Gene Research Centre (Beijing) Beijing China Key Laboratory of Biomedical Polymers; Engineering Research Center of Organosilicon Compounds & Materials; Ministry of Education; College of Chemistry and Molecular Sciences; Wuhan University Department of Civil and Environmental Engineering, University of Washington, Seattle, Washington 98195, United States; Center for Urban Waters, Tacoma, Washington 98421, United States Institute of Atomic and Molecular Physics, Jilin University, Changchun 130012, China School of Ophthalmology & Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou 325027, China School of Life Sciences, Key Laboratory of Preclinical Study for New Drugs of Gansu Province, and School of Pharmacy, Lanzhou University, Lanzhou 730000, China South China Institute of Environmental Sciences, Ministry of Ecology and Environment, Guangzhou 510655, China National Center for Nanoscience and Technology, Zhongguancun, Beijing 100190, China; Academy of Advanced Interdisciplinary Studies, Peking University, Beijing, 100871, China School of Pharmaceutical Sciences, Capital Medical University, Beijing, 100069, China Department of Chemistry and The RNA Institute, University at Albany, State University of New York Albany New York Department of Cardiology, Yangpu District Central Hospital, Shanghai 200090, China. wangruinol@sina.com MOE Key Laboratory of Bioinformatics, Center for Synthetic and System Biology, Tsinghua University, Beijing 100084, China; School of Life Sciences, Tsinghua University, Beijing 100084, China Jiangxi Key Laboratory of Organic Chemistry, Jiangxi Science and Technology Normal University, Nanchang, Jiangxi, PR China The First Affiliated Hospital of Guangzhou Medical University Guangzhou China; Department of Clinical Medicine, First Clinical School Guangzhou Medical University Guangzhou China Key Laboratory of Industrial Biotechnology, Ministry ofEducation, Cencter for Brewing Science and Enzyme Technology, Jiangnan University, Wuxi 214122, China. Department of Emergency and Critical Care Medicine, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China School of Physics and Electronic Engineering, Zhengzhou University of Light Industry, Zhengzhou 450002, China Department of Mathematics, College of Natural Science Michigan State University East Lansing Michigan USA Office of Health Care, Hefei Municipal Health Commission, Hefei 230071, China Key Laboratory of Flexible Electronics (KLOFE) and Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing Tech University (NanjingTech); Nanjing 211816; P. R. China College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, P. R. China Department of Ultrasonography, Shanghai Jiaotong University Affiliated No. 6 Hospital, Shanghai 200233, PR China; Shanghai Institute of Ultrasound in Medicine, Shanghai 200233, PR China State Key Lab for Agro-Biotechnology and Ministry of Agriculture Key Lab of Soil Microbiology, College of Biological Sciences, China Agricultural University, Beijing, China School of Nursing and Rehabilitation Shandong University Jinan Shandong China Department of Population Medicine, Harvard Medical School/Harvard Pilgrim Health Care Institute, Boston, MA.; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA. University of Electronic Science and Technology of China Aging Research Center, Department of Neurobiology, Care Sciences and Society (NVS) Karolinska Institutet-Stockholm University Stockholm Sweden Department of Chemistry The RNA Institute University at Albany State University of New York 1400 Washington Ave. Albany NY 12222 USA Shenzhen Engineering Laboratory of Phosphorene and Optoelectronics; Collaborative Innovation Center for Optoelectronic Science and Technology; College of Optoelectronic Engineering; Shenzhen University; Shenzhen 518060 State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Macau, China State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, Nanjing 211816, China; College of Food Science and Light Industry, Nanjing Tech University, Nanjing 211816, China Department of Medical Oncology, Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu 210002, P.R. China Clinical Laboratory and Shaanxi Provincial Institute for Tuberculosis Control and Prevention, Xi'an, China. Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences; Institute of Biochemistry and Molecular Biology, School of Life Sciences, Lanzhou University; 222 Tian Shui South Road Lanzhou 730000 China Military Medical Center, Tangdu Hospital, Fourth Military Medical University, Xi'an 710038, China. University of Chinese Academy of Science Beijing 100049 P. R. China; State Key Laboratory of Multiphase Complex Systems Institute of Process Engineering Chinese Academy of Sciences Beijing 100190 P. R. China Wisconsin Alzheimer's Disease Research Center University of Wisconsin School of Medicine and Public Health Madison Wisconsin USA; The Swedish School of Sport and Health Sciences GIH Stockholm Sweden; Department of Neurobiology Care Sciences and Society Karolinska Institutet Stockholm Sweden Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University, Lanzhou, 730000, China State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, Nanjing, China; College of Food Science and Light Industry, Nanjing Tech University, Nanjing, China State Key Laboratory for Agro-Biotechnology, College of Biological Sciences, China Agricultural University, Beijing 100193, PR China Key Laboratory of Biochemistry and Molecular Biology in Universities of Shandong Province, Weifang University, Weifang 261061, China School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, People’s Republic of China Department of Pharmacy, Medical Supplier Center, Center of Medicine Clinical Research PLA General Hospital Beijing China 1Shenyang Pharmaceutical University, Shenyang, China; Department of Neurology, First Hospital of Shanxi Medical University, Taiyuan 030001, Shanxi, P.R. China Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA China General Microbiological Culture Collection Center, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, PR China; School of Biotechnology and Food Science, Tianjin University of Commerce, Tianjin, PR China Institute of Carbon Neutrality & School of New Energy and Materials, Southwest Petroleum University, Chengdu, Sichuan 610500, China Department of Medicine, Brigham and Women's Hospital and Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA Research Center of Medical Science, Qiqihar Medical University, Qiqihar, China; Department of Biological and Chemical Engineering, Chongqing University of Education, Chongqing 400067, China. Department of Thoracic Surgery, Shanghai Cancer Hospital, Fudan University, Shanghai, China Department of Chemistry; Northeast Normal University; Changchun 130024; China Department of Chemistry, Institute of Biomimetic Materials and Chemistry, Anhui Engineering Laboratory of Biomimetic Materials, University of Science and Technology of China, Hefei 230026, China Department of Pharmacy, Shanghai Zhongye Hospital, Shanghai, China Bristol Myers Squibb, Princeton, NJ Shanghai Key Laboratory of New Drug Design, State Key Laboratory of Bioreactor Engineering, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China University of Washington, Department of Mechanical Engineering, Seattle, Washington, United States West China Centre of Excellence for Pancreatitis, Institute of Integrated Traditional Chinese and Western Medicine, Sichuan Provincial Pancreatitis Centre and West China-Liverpool Biomedical Research Centre, West China Hospital/West China Medical School, Sichuan University, Chengdu 610041, China; Advanced Mass Spectrometry Center, Research Core Facility, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu 610041, China Department of Sports Injury and Arthroscopy Tianjin Hospital Tianjin China Key Laboratory of Pesticide and Chemical Biology (CCNU) Ministry of Education College of Chemistry Central China Normal University Wuhan 430079 P.R. China Department of Biological Medicines & Shanghai Engineering Research Center of Immunotherapeutics, Fudan University School of Pharmacy, Shanghai, People’s Republic of China Department of Clinical Laboratory Medicine Shanghai Tenth People's Hospital of Tongji University Shanghai 200072 China Department of Urology, First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan 450052, China. Shanxi Key Laboratory of Grassland Ecological Protection and Native Grass Germplasm Innovation, College of Grassland Science, Shanxi Agricultural University, Taigu 030801, China; Youyu Loess Plateau Grassland Ecosystem Research Station, Shanxi Agricultural University, Taigu 030801, China Monash University; Department of Obstetrics and Gynaecology; Clayton VIC Australia 3168; The University of Adelaide; Robinson Research Institute and Adelaide Medical School; Adelaide SA Australia 5005 Chongqing Key Laboratory for Advanced Materials and Technologies of Clean Energy School of Materials & Energy Southwest University Chongqing 400715 P.R. China Nursing School Guizhou University of Traditional Chinese Medicine Guiyang China Institute of Pharmacology Toxicology and Biochemical Pharmaceutics Zhejiang University Hangzhou China Taiyuan Center for Disease Control and Prevention, 89 Xinjian South Road, Taiyuan 030012, China School of Public Health, Jilin University, Changchun, Jilin, China Viterbi School of Engineering University of Southern California Los Angeles California USA State Key Laboratory of Agricultural Microbiology, College of Plant Science and Technology, Huazhong Agricultural University, Wuhan, Hubei, China Department of Ultrasonography Shanghai Jiao Tong University Affiliated No. 6 Hospital Shanghai 200233 People's Republic of China; Shanghai Institute of Ultrasound in Medicine Shanghai 200233 People's Republic of China Department of Emergency, the First Hospital, China Medical University, China Beijing University of Chinese Medicine, Beijing 100102, China. State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, China Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai 200032, China; Shanghai Institute of Cardiovascular Diseases, Shanghai 200032, China; National Clinical Research for Interventional Medicine, Shanghai 200032, China Department of Dermatology, Chinese People's Liberation Army General Hospital, Medical College of the Chinese People's Liberation Army, Beijing 100853, P.R. China European Molecular Biology Laboratories, Meyerhofstrasse 1, 69117 Heidelberg, Germany. Department of Orthopedic Surgery, Peking University First Hospital, Beijing 100034, China Shandong Provincial Key Laboratory of Plant Stress Research, College of Life Sciences, Shandong Normal University, Ji’nan, Shandong, China State Key Laboratory of Tree Genetics and Breeding, Northeast Forestry University, Harbin, China Department of Massage Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University Hangzhou China Xi'an Jiaotong University 1 Key Laboratory for Physical Electronics and Devices of the Ministry of Education, Department of Electronic Science and Technology, , Xi'an 710049, People's Republic of China Changchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Sciences, Changchun 130033, China From the Chinese Center for Disease Control and Prevention, Beijing (Q.L., X.W., L.Z., R.R., N.X., C.L., D.L., J.Z., W.T., L.J., Q.W., R.W., Y.Z., G. Shi, G.F.G., Z.F.), the Hubei Provincial Center for Disease Control and Prevention, Wuhan, Hubei (X.G., Y.T., X.X., Y.W., Q.C., M.L., C.C., R.Y., S.Z., Y. Luo, B.Y.), the World Health Organization Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, University of Hong Kong, Hong Kong (P.W., K.S.M.L., E.H.Y.L., J.Y.W... State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation, Southwest Petroleum University, Chengdu, Sichuan 610500, China; School of New Energy and Materials, Southwest Petroleum University, Chengdu, Sichuan 610500, China University of Chinese Academy of Sciences Beijing 100049 P. R. China Guanghua Hospital, Affiliated to Shanghai University of Traditional Chinese Medicine, Institute of Arthritis Research in Integrative Medicine, Shanghai Academy of Traditional Chinese Medicine, Shanghai, China; Shanghai University of Traditional Chinese Medicine, Shanghai, China Pingshan Translational Medicine Center, Shenzhen Bay Laboratory, Shenzhen, China Department of Radiology and Radiological Science, Medical University of South Carolina, 25 Courtenay Drive MSC 226, Charleston, SC 29425, USA; Department of Radiology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China Department of Andrology, Research Institute of Male Diseases, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan 450052, China. Department of Cardiology, The First Hospital of China Medical University, 155 North Nanjing Street, Shenyang 110001, China Department of Neurology, Affiliated Hospital of Qingdao University Medical College, Qingdao 266003, Shandong Province, China. Cardiovascular and Metabolic Research Unit Lakehead University Thunder Bay ON Canada; Department of Biology Lakehead University Thunder Bay ON Canada Department of Physiology, Shihezi University Medical College and the Key Laboratory of Xinjiang Endemic and Ethnic Diseases, Shihezi 832002, China. Lily7588@163.com. Beijing State Key Laboratory of Organic-Inorganic Composites & Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, Beijing 100029, P. R. China Department of General Surgery Fudan University Affiliated Huadong Hospital No. 221, West Yan'an Road, Jing'an District 200040 Shanghai People's Republic of China Sanya Nanfan Research Institute Hainan University Sanya PR China; School of Tropical Agriculture and Forestry, Engineering Center of Agricultural Microbial Preparation Research and Development of Hainan Hainan University Haikou PR China Key Laboratory of MEMS of the Ministry of Education, Southeast University, Nanjing 210096, China Institutes of Physical Science and Information Technology, Leibniz International Joint Research Center of Materials Sciences of Anhui Province, Anhui Province Key Laboratory of Environment-Friendly Polymer Materials, Key Laboratory of Structure and Functional Regulation of Hybrid Material (Ministry of Education), Anhui University, Hefei 230601, China Collaborative Innovation Center for Optoelectronic Science and Technology and Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province; Shenzhen University; Shenzhen 518060; P. R. China CAS Key Laboratory of Urban Pollutant Conversion, Department of Environmental Science and Engineering, University of Science & Technology of China, Hefei 230026, China Anhui Key Laboratory of Tissue Transplantation Bengbu Medical College Bengbu P.R. China College of Chemistry, Chemical Engineering and Materials Science Soochow University Suzhou 215123 China Department of Cardiology, Zhongshan Hospital, Research Unit of Cardiovascular Techniques and Devices, Chinese Academy of Medical Sciences Fudan University Shanghai China; National Clinical Research Center for Interventional Medicine Shanghai China; Shanghai Institute of Cardiovascular Diseases Shanghai China Department of Electronic and Electrical Engineering, Southern University of Science and Technology, No 1088, Xueyuan Rd., Xili, Nanshan District, Shenzhen 518055, Guangdong, P. R. China School of Nursing, Guangdong Pharmaceutical University Guangzhou 510310, China. Sanya Nanfan Research Institute of Hainan University Sanya PR China; Key Laboratory of Green Prevention and Control of Tropical Diseases and Pests (College of Plant Protection, Hainan University), Ministry of Education Haikou PR China The Key Laboratory of Life-Organic Analysis, Key Laboratory of Pharmaceutical Intermediates and Analysis of Natural Medicine, College of Chemistry and Chemical Engineering, Qufu Normal University, Qufu 273165, China College of Food Science and Engineering, Ocean University of China, Qingdao 266003, China Department of Biological Medicines & Shanghai Engineering Research Center of Immunotherapeutics, Fudan University School of Pharmacy, Shanghai, China Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology Brigham and Women's Hospital and Harvard Medical School 221 Longwood Avenue MA 02115 Boston U.S.A.; Department of Biostatistics Harvard T. H. Chan School of Public Health 655 Huntington Avenue Boston 02115 MA U.S.A. Department of Biology and Authors' Affiliations: 1Key Laboratory of Cell Proliferation and Regulation of the Ministry of Education, Beijing Normal University; and 2Universities of the Confederated Institute for Proteomics, Beijing, China Beijing Key Laboratory for HIV/AIDS Research, Sino-French Joint Laboratory for Research on Humoral Immune Response to HIV Infection, Clinical and Research Center for Infectious Diseases, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China Department of Ultrasound in Medicine Shanghai Jiaotong University Affiliated Sixth People's Hospital Shanghai Institute of Ultrasound in Medicine Shanghai China College of Computer Science and Technology, Beihua University, No. 3999 East Binjiang Road, Jilin 132013, China School of Advanced Materials, Peking University, Shenzhen Graduate School, Shenzhen 518055, China School of Materials Science and Engineering Harbin Institute of Technology Harbin 150001 China College of Food and Pharmaceutical Sciences, Ningbo University, Ningbo, China Department of Pharmacy, Qilu Hospital of Shandong University, 107 Wenhua Xilu, Jinan 250012, P.R. China; Department of Pharmaceutics, Key Laboratory of Chemical Biology (Ministry of Education), NMPA Key Laboratory for Technology Research and Evaluation of Drug Products, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, P.R. China; Department of Pharmacy, Qilu Hospital of Shandong University (Qingdao), No. 758 Hefei Road, Qingdao, 266035, P.R. China Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Medicine, State Key Laboratory of Applied Organic Chemistry, and Institute of Biochemistry and Molecular Biology, Lanzhou University, Lanzhou 730000, P. R. China; State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China Key Laboratory of Green Fabrication and Surface Technology of Advanced Metal Materials (Anhui University of Technology), Ministry of Education, Maanshan, 243002, China Faculty of Material Science and Chemistry China University of Geosciences Wuhan 430074 China School of Chemistry and Chemical Engineering, Henan University of Technology, Zhengzhou 450001, PR China; Key Laboratory of High Specific Energy Materials for Electrochemical Power Sources of Zhengzhou City, Henan University of Technology, Zhengzhou 450001, PR China Department of Nephrology Division of Nanophotonics CAS Key Laboratory of Standardization and Measurement for Nanotechnology CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology Beijing 100190 China Department of Chemical and Biological Engineering The Hong Kong University of Science and Technology Hong Kong SAR China 2Translational Oncology, AbbVie Inc., North Chicago, Illinois. School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006 China; Key Laboratory of Preclinical Study for New Drugs of Gansu Province, Lanzhou University, Lanzhou, 730000 China Division of Pharmaceutics, Hokkaido Pharmaceutical University School of Pharmacy Department of Neurosurgery Second Affiliated Hospital School of Medicine Zhejiang University Hangzhou Zhejiang China; Clinical Research Center for Neurological Diseases of Zhejiang Province Hangzhou China Beijing Key Laboratory of Big Data Technology for Food Safety, School of Computer Science and Engineering, Beijing Technology and Business University, Beijing 100048, China State Key Laboratory of Bioreactor Engineering, Shanghai Key Laboratory of New Drug Design, and ‡Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China Department of Urology, The First Affiliated Hospital of Harbin Medical University, No. 23 You Zheng Street, Harbin, 150001 Heilongjiang, China Tianjin University Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University, 730000 Lanzhou, China; State Key Laboratory for Biology of Plant Diseases and Insect Pests Institute of Plant Protection, Chinese Academy of Agricultural Sciences Beijing 100193 China Department of Oncology, Anhui Chest Hospital, Hefei, Anhui 230022, P.R. China VOMMA (Shanghai) Technology Co. Ltd 2 , Nerobay 1, 951 Jianchuan Road, Shanghai, China Department of Medical Genetics and Prenatal Screening, Maternity and Child Health Care of Zaozhuang, Zaozhuang, Shandong 277102, China. weiyouhua1986@foxmail.com. Jiangsu Key Laboratory of Crop Cultivation and Physiology/Co-Innovation Center for Modern Production Technology of Grain Crops/Innovation Center of Rice Cultivation Technology in Yangtze Valley, Ministry of Agriculture and Rural Affairs, Research Institute of Rice Industrial Engineering Technology, Yangzhou University, Yangzhou 225009, China College of Agronomy, Shenyang Agricultural University, Shenyang 110866, China. wangrui1987624@163.com Department of Health Statistics, Second Military Medical University, Shanghai 200433, China Department of Radiology, The First Affiliated Hospital of Anhui Medical University , Hefei , China; Research Center of Clinical Medical Imaging , Anhui Province, Hefei , China; Anhui Provincial Institute of Translational Medicine , Hefei , China; Anhui Provincial Key Laboratory for Brain Bank Construction and Resource Utilization , Hefei , China School of Public Health, Ningxia Medical University, Yinchuan 750004, China; The Key Laboratory of Environmental Factors and Chronic Disease Control of Ningxia, Yinchuan 750004, China State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China Claude Pepper Institute and Department of Chemistry Florida Institute of Technology Melbourne Florida Center of Integrative Medicine, Beijing Ditan Hospital, Capital Medical University Department of Geriatrics, China-Japan Union Hospital of Jilin University, Changchun, Jilin, China Department of Gastroenterology, West China Hospital, Sichuan University, Chengdu 610041, China. School of Pharmacy; Heilongjiang University of Chinese Medicine; Harbin 150040; China School of Materials Science and Engineering Beihang University Beijing 100191 P. R. China College of Animal Science and Technology Shaan'xi Key Laboratory of Molecular Biology for Agriculture Northwest A&F University YangLing Shaan'xi 712100 PR China Key Laboratory of Marine Chemistry Theory and Technology, Ministry of Education, College of Chemistry and Chemical Engineering, Ocean University of China, Qingdao 266100, China Reproductive Medicine Center Department of Obstetrics and Gynecology Affiliated Hospital of Guizhou Medical University Guiyang China West China Hospital, Sichuan University, Chengdu, China Institute for Nutrition and Food Safety, Chinese Center for Disease Control and Prevention, Beijing 100050, China. Department of Clinical Pharmacology, PLA (301) General Hospital, 28 Fuxing Road, Haidian District, Beijing 100853, China Beijing Key Laboratory of Energy Conversion and Storage Materials and College of Chemistry, Beijing Normal University, Beijing 100875, China Department of Nephrology, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing, PR China Catalytic Materials Division; Shenyang National Laboratory for Materials Science; Institute of Metal Research; Chinese Academy of Sciences; Shenyang 110016, China Key Laboratory of Pharmacokinetics, China Pharmaceutical University Department of Materials Science and Engineering California NanoSystems Institute University of California Los Angeles CA 90095 USA Department of Nephrology, Zhenzhou Central Hospital, Affiliated to Zhengzhou University, Zhengzhou City, Henan Province 450000, China NHC Key Laboratory of Radiobiology, School of Public Health, Jilin University, Changchun, China East China University of Science and Technology; School of Pharmacy; Shanghai; China National Laboratory of Solid State Microstructures, School of Physics, and Collaborative Innovation Center for Advanced Microstructures, Nanjing University, Nanjing 210093, China Department of Gastroenterology and Hunan Key Laboratory of Nonresolving Inflammation and Cancer, The Third Xiangya Hospital, Changsha, Hunan China Department of Trauma Intensive Care Unit, the first affiliated hospital of Xinjiang medical university, Urumqi 830054, China Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China School of Life Sciences; School of Basic Medical Sciences; Institute of Biochemistry and Molecular Biology; and Key Laboratory of Preclinical Study for New Drugs of Gansu Province; Lanzhou University State Key Laboratory of Natural Medicines, China Pharmaceutical University, No. 639 Longmian Dadao, Nanjing 211198, China Key Laboratory of Colloid and Interface Chemistry, Shandong University, Ministry of Education, Jinan, 250100, PR China 1Sanofi, Oncology Clinical Translational Medicine, Cambridge, Massachusetts. Department of Radiology, and China-Japan Union Hospital of Jilin University, Changchun, China. Department of Thoracic Surgery Fudan University Shanghai Cancer Center Shanghai China; Department of Oncology Shanghai Medical College Fudan University Shanghai China Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy, China Three Gorges University , Yichang, 443002, China; College of Basic Medical Science, China Three Gorges University, Yichang , 443002, China Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, College of Life Sciences, Northwest University, Xi’an, China; College of Medical Science, Three Gorges University, Yichang, Hubei 443002, China Anhui Key Laboratory of Tissue Transplantation First Affiliated Hospital of Bengbu Medical College Bengbu People's Republic of China *Department of Microbiology and Immunology, School of Medicine, University of Texas Health Science Center, San Antonio, TX 78229;; ‡Xiangya Medical School, Central South University of China, 410000 Changsha, Hunan Province, China; School of Pharmaceutical Sciences; Sun Yat-sen University; Guangzhou; China; Key Laboratory of Preclinical Study for New Drugs of Gansu Province Xin'an Medicine Research Center the First Affiliated Hospital of Wannan Medical College (Yijishan Hospital) Wuhu 241000 China Key Laboratory of Leather Chemistry and Engineering of Ministry of Education, College of Biomass Science and Engineering, Sichuan University, Chengdu 610065, China WHO WPRO Regional Polio Reference Laboratory, National Health Commission Key Laboratory for Biosafety, National Health Commission Key Laboratory for Medical Virology, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, 155 Changbai Road, Beijing 102206, China Department of Oncology, The Affiliated Hospital of Guizhou Medical University, Guiyang, China; Department of Head and Neck Oncology, Guizhou Cancer Hospital, Guiyang, PR China Department of Ultrasound, The Third Affiliated Hospital of Xuzhou Medical University College of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou 310058, China College of Electronic & Information Engineering, Chongqing Three Gorges University, Chongqing 404100, China Department of Cardiovascular Surgery, Xuzhou Cancer Hospital, Xuzhou, Jiangsu 221005, China School of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing, 400054, China; Key Laboratory of Screening and Activity Evaluation of Targeted Drugs, Chongqing, 400054, China Institute of Organ Transplantation, Zhejiang University Hangzhou China 2Pathology, Department of Digestive Diseases of Huashan Hospital, Fudan University Shanghai 200040, China ; Institutes of Biomedical Sciences and Department of Immunology of Shanghai Medical School, Fudan University Shanghai, 200032, China. Department of Sport Injury and Arthroscopy, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, P.R. China State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation, Southwest Petroleum University, Chengdu, Sichuan Province 610500, China; Carbon Neutralization Research Institute, School of New Energy and Materials, Southwest Petroleum University, Chengdu, Sichuan Province 610500, China Department of Urology, First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052. huzi918@126.com Department of Biotherapy Tianjin Medical University Cancer Institute and Hospital Tianjin China; National Clinical Research Center for Cancer Tianjin China; Key Laboratory of Cancer Prevention and Therapy Tianjin China Division of Nanomaterials & Chemistry, Hefei National Laboratory for Physical Sciences at the Microscale, Institute of Energy, Hefei Comprehensive National Science Center, CAS Center for Excellence in Nanoscience, Department of Chemistry, Institute of Biomimetic Materials & Chemistry, University of Science and Technology of China, Hefei 230026, China Department of Dermatology First Medical Center of Chinese PLA General Hospital Beijing China West China School of Pharmacy, Sichuan University P.R. CHINA Department of Chemistry; The RNA Institute; University at Albany; State University of New York; Albany Key Laboratory of Preclinical Study for New Drugs of Gansu Province, Lanzhou University, Lanzhou 730000, China Biomedical Engineering College, Capital University of Medical Sciences. Department of Thoracic Surgery, Shanghai Chest Hospital, Shanghai Jiaotong University, Shanghai, China State Key Laboratory of Cellular Stress Biology, School of Life Sciences Xiamen University Xiamen China Anhui University of Chinese Medicine, Heifei 230038, China Faculty of Science, York University, Toronto, ON, Canada Institute of Mineral Resources, Chinese Academy of Geological Sciences, Beijing 100037, China. wangruijoy@126.com College of Resources and Environment, Northwest A & F University, Yangling 712100, China. School of Petroleum Engineering, Yangtze University, Wuhan, Hubei430100, China School of Ocean Sciences, China University of Geosciences (Beijing), Beijing 100083, China Department of Physiology, University of Saskatchewan, Saskatoon, Saskatchewan, Canada S7N 5E5 Department of Radiology, Beijing Anzhen Hospital, Capital Medical University, 2 Anzhen Rd, 100029 Beijing, China. Department of Respiratory Oncology Fushan district people's hospital Yantai China Beijing WaveQuanta Technology Co., Ltd. College of Life Sciences, Jilin Agricultural University, Changchun, China Lalin Railway Construction Headquarters of China Railway Corporation, Linzhi 860114, China Advanced Mass Spectrometry Center, Research Core Facility, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu 610041, China College of Plant Protection, Jilin Agricultural University, Changchun, 130118, China Luohu Center for Chronic Disease Control, Shenzhen, Guangdong, 518000, China Department of Medical Oncology, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, Jiangsu 210002, China Center of Medicine Clinical Research, Department of Pharmacy, PLA General Hospital, Beijing, People’s Republic of China Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, PR China Center for Supramolecular Chemistry & Catalysis and Department of Chemistry, College of Science, Shanghai University, 99 Shang-Da Road, Shanghai 200444, China Department of Hepatobiliary and Pancreatic Surgery The Center for Integrated Oncology and Precision Medicine Affiliated Hangzhou First People's Hospital Zhejiang University School of Medicine Hangzhou China; Zhejiang University Cancer Center Hangzhou China; Department of Hepatobiliary and Pancreatic Surgery The First Affiliated Hospital Zhejiang University School of Medicine Hangzhou China; NHC Key Laboratory of Combined Multi‐organ Transplantation Hangzhou China; Institute of Organ Transplantation Zhejiang University Hangzhou China From the Department of Biostatistics, University of Florida, Gainesville (N.E.D., I.M.L.); the World Health Organization, Geneva (P.-S.G., A.M.H.-R.); the Department of Biostatistics, University of California, Los Angeles (R.B.); the Department of Biostatistics, Yale University, New Haven, CT (F.W.C.); the Department of Statistics (C.A.D.) and the Centre for Tropical Medicine and Global Health (P.H.), University of Oxford, Oxford, the Medical Research Council (MRC) Centre for Global Infectious Disease... State Key Laboratory of Quality Research in Chinese Medicine/Macau Institute for Applied Research in Medicine and Health Macau University of Science and Technology Macau China Center of Medicine Clinical Research, Translational Medical Center, Chinese PLA General Hospital, Beijing, China Nanjing Cardiovascular Hospital, Nanjing Medical University, Nanjing 210006, China. College of Food Science and Engineering, Ocean University of China, Qingdao, Shandong Province, China From the Department of Biology, Lakehead University, Thunder Bay, ON, Canada (S.M., H.L., R.W.); Department of Health Sciences, Lakehead University, Thunder Bay Regional Research Institute, Thunder Bay, ON, Canada (A.U., L.W.); The School of Kinesiology, Lakehead University, Thunder Bay, ON, Canada (G.Y.); Department of Medicine, Division of Nephrology, McMaster University, St.Joseph’s Healthcare Hamilton and Hamilton Centre for Kidney Research, Hamilton, ON, Canada (R.C.S., J.G.D., S.L.); and... Engineering Research Center of Nano-Geomaterials; Ministry of Education; Faculty of Material and Chemistry; China University of Geosciences; Wuhan 430074 †Department of Genetic Medicine, Weill Cornell Medical College, New York, NY 10065; Department of Physiology, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada.; Department of Pharmacology, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada.; Department of Pathology, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada.; Departments of Neuroscience, Pharmacology and Molecular Sciences and Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.; Department of Biology, Lakehead University, Thunder Bay, ON P7B 5E1, Canada. School of Agronomy, Ningxia University, Yinchuan, P. R. China;; Ningxia Engineering and Technology Research Center of Grape and Wine, Ningxia University, Yinchuan, P. R. China;; Engineering Research Center of Grape and Wine, Ministry of Education, Ningxia University, Yinchuan, P. R. China; Department of Medical Oncology, Jinling Hospital, School of Medicine, Nanjing University, Nanjing 210002, Jiangsu China Department of Physiology and Pathophysiology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, 5 Dong Dan San Tiao, Beijing 100005, P.R. China.; Department of Biology, Lakehead University, Thunder Bay, ON P7B 5E1, Canada. Garrison Institute on Aging, Texas Tech University Health Sciences Center, Lubbock, TX, 79430, USA; Neuroscience & Pharmacology Department, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA 1State Key Laboratory of Cancer Biology and Xijing Hospital of Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi'an, China. Department of Cardiology, The First Hospital, Shanxi Medical University, Taiyuan 030001. Department of Public Economics, School of Economics, Xiamen University, Xiamen, China Third Institute of Oceanography, Ministry of Natural Resources, Xiamen, China Department of Urology Qilu Hospital of Shandong University Jinan China Department of Materials Science and Engineering and California NanoSystems Institute University of California Los Angeles Los Angeles CA 90095 USA College of Public Health, Zhengzhou University, Zhengzhou, Henan, P.R. China National Laboratory of Solid State Microstructures, Collaborative Innovation Center of Advanced Microstructures, and School of Physics, Nanjing University, Nanjing 210093, China; Department of Physics and Astronomy, Shanghai Jiao Tong University, Shanghai 200240, China College of Information Science and Engineering, Guangxi University for Nationalities, Nanning, China; Guangxi High School Key Laboratory of Complex System and Computational Intelligence, Guangxi University for Nationalities, Nanning, China State Key Laboratory of Applied Organic Chemistry, Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, and College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, 730000, People’s Republic of China Department of Cardiology Yangpu Hospital, Tongji University Shanghai China Shanghai Key Laboratory of New Drug Design, Department of Pharmaceutical Science, School of Pharmacy, East China University of Science and Technology, Shanghai, PR China Department of Medical Oncology School of Medicine Jinling Hospital Nanjing University Nanjing Jiangsu China Division of Sleep and Circadian Disorders, Brigham and Women’s Hospital, Boston, MA; Division of Sleep Medicine, Harvard Medical School, Boston, MA Center for Inflammation and Epigenetics Houston Methodist Research Institute Houston TX Department of Pharmacology Key Laboratory of Preclinical Study for New Drugs of Gansu Province Institute of Biochemistry and Molecular Biology School of Basic Medical Sciences Lanzhou University Lanzhou China Department of Biology, Lakehead University, Thunder Bay, Canada. Key Laboratory of Smart Drug Delivery, School of Pharmacy, Fudan University, Shanghai 201203, China State Key Laboratory of Crop Genetics and Germplasm Enhancement, College of Agriculture, Nanjing Agricultural University, Nanjing, China Department of Cardiology Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine Shanghai China; Department of Cardiology Center Hospital of Putuo District Shanghai China Institute of Functional Materials and Molecular Imaging; Key Laboratory of Emergency and Trauma; Ministry of Education; Key Laboratory of Hainan Trauma and Disaster Rescue; College of Clinical Medicine Department of Pharmaceutical Science School of Pharmacy Shanghai Key Laboratory of New Drug Design East China University of Science and Technology Shanghai China Center for Translational Cancer Research Institute of Biosciences and Technology Texas A&M University Houston TX 77030 USA School of Public Health Bengbu Medical College Bengbu China Key Laboratory of Colloid and Interface Chemistry, Shandong University, Ministry of Education, Jinan 250100, People's Republic of China College of Life Sciences, Anhui Normal University, Wuhu, China University East RoadNanning, Guangxi, China, 530007, ; Department of Gastroenterology and Hepatology, Tianjin Medical University General Hospital, Tianjin 300000, China Molecular Biology Section, Laboratory of Immunology, NIAID, National Institutes of Health, Bethesda, MD 20892-1892, USA Chongqing Collaborative Innovation Center for Functional Food, Chongqing University of Education, Chongqing 400067, China; Chongqing Engineering Research Center of Functional Food, Chongqing University of Education, Chongqing 400067, China; Chongqing Engineering Laboratory for Research and Development of Functional Food, Chongqing University of Education, Chongqing 400067, China Key Laboratory for Resources Use & Environmental Remediation, Institute of Geographic Sciences and Natural Resources Research, Chinese Academy of Sciences, Beijing 100101, China. Division of Nephrology, Renmin Hospital of Wuhan University, Wuhan 430060, China Center for Life Sciences, Peking University, Beijing 100871, China; College of Food Science, Southwest University, Chongqing 400715, China; State Key Laboratory of Southwestern Chinese Medicine Resources, School of Public Health, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China; Collaborative Innovation Center for Child Nutrition and Health Development, Chongqing University of Education, Chongqing 400067, China Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun 130021, China Department of General Surgery, Hongqi Hospital Affiliated to Mudanjiang Medical College, Mudanjiang, Heilongjiang 157000, P.R. China State Key Laboratory of Oral Diseases, Sichuan University, Chengdu 610041, China. Department of Pediatric Critical Care, Yuxi Children’s Hospital, Yuxi, Yunnan, China. Bristol-Myers Squibb, Princeton, New Jersey School of Health Service Management, Anhui Medical University Research Center of Gansu Military and Civilian Integration Advanced Structural Materials Key Laboratory of Eco‐Environment‐Related Polymer Materials Ministry of Education of China Key Laboratory of Polymer Materials of Gansu Province College of Chemistry and Chemical Engineering Northwest Normal University Lanzhou Gansu 730000 China Beijing University of Chinese Medicine; Department of Ophthalmology, China-Japan Friendship Hospital, Beijing, China. The First Clinical Medical College, Shaanxi University of Chinese Medicine, Xi’an, Shaanxi Province, China State Key Laboratory of Cellular Stress Biology School of Life Sciences Innovation Center for Cell Signaling Network Xiamen University Xiamen Fujian 361005 China Department of Chemical Engineering; Massachusetts Institute of Technology; Cambridge; USA National-Local Joint Engineering Laboratory of New Energy Photoelectric Devices, College of Physics Science and Technology, Hebei University, Baoding 071002, China Chinese PLA 306 Hospital, Beijing 100000, P.R. China. Department of Physics, National University of Singapore, 3 Science Drive 2, Singapore 117542 Chongqing Engineering Research Center for Rapeseed, College of Agronomy and Biotechnology, Southwest University, Beibei, Chongqing 400715, P.R. China.; Chongqing Engineering Research Center for Rapeseed, College of Agronomy and Biotechnology, Southwest University, Beibei, Chongqing 400715, P.R. China. State Key Laboratory of Advanced Metallurgy School of Metallurgical and Ecological Engineering University of Science and Technology Beijing Beijing 100083 China; Department of Energy Storage Science and Engineering School of Metallurgical and Ecological Engineering University of Science and Technology Beijing Beijing 100083 China Key Laboratory of Preclinical Study for New Drugs of Gansu Province, Lanzhou University, Lanzhou 730000, P.R. China School of Textile Science and Engineering, Tiangong University, Tianjin 300387, China Department of Hematology, The First Hospital of Jilin University Department of Blood Transfusion, Qilu Hospital of Shandong University (Qingdao), Shandong, People's Republic of China From the Aging Research Center (C.S.D., A.M., D.R., R.W., J.S., W.X.), Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University; Department of Clinical Neuroscience (J.S.), Psychology Division, Karolinska Institutet, Stockholm, Sweden; Department of Biomedical Engineering (K.A.), Illinois Institute of Technology, Chicago; Rush Alzheimer's Disease Center (K.A., D.A.B.), and Department of Neurological Sciences (D.A.B.), Rush University Medical Center,... Department of Nephrology the Affiliated Huaihai Hospital of Xuzhou Medical University Xuzhou China National Center for Nanoscience and Technology, Beijing 100190, P. R. China, and Graduate School of the Chinese Academy of Sciences, Beijing 100039, P. R. China Department of Neurosurgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.; Clinical Research Center for Neurological Diseases of Zhejiang Province, Hangzhou, China. Chinese PLA General Hospital, China National Laboratory of Solid State Microstructures, School of Physics, and Collaborative Innovation Center of Advanced Microstructures, Nanjing University, Nanjing 210093, China Engineering Research Center of Nano‐Geomaterials of Ministry of Education Faculty of Material and Chemistry China University of Geosciences Wuhan 430074 China From the Department of Physiology and Biophysics, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, IL (J.C., C.W.); and Cardiovascular and Metabolic Research Unit, Laurentian University, Sudbury, Canada (R.W.). State Key Laboratory for Food Nutrition and Safety, College of Food Science and Engineering, Tianjin University of Science and Technology, Tianjin, 300457, China State Key Laboratory of Clean Energy Utilization, College of Energy Engineering Zhejiang University Hangzhou 310027 China College of Basic Medicine, Hebei University of Chinese Medicine, Shijiazhuang, China Key Laboratory of Cell Biology and Medical Cell Biology, Department of Stem Cells and Regenerative Medicine, National Health Commission of China, Ministry of Education of China, China Medical University, Shenyang, Liaoning 110122, P.R. China CAS Key Laboratory of Microbial Physiological and Metabolic Engineering, State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences , Beijing , China National Key Facility for Crop Gene Resources and Genetic Improvement (NFCRI), Institute of Crop Sciences, Chinese Academy of Agriculture Sciences (CAAS), Beijing 100081, China Zhenjiang Key Laboratory of Medical Immunology, Department of Laboratory Medicine, Affiliated Hospital of Jiangsu University, Zhenjiang, China Authors' Affiliations: 1The Division of Hematology/Oncology, Department of Medicine, The Tisch Cancer Institute, Mount Sinai School of Medicine, New York, New York; and 2School of Pharmaceutical Sciences, Shandong University, Jinan, Shandong, China Harbin Institute of Technology 3 Department of Chemistry, , Harbin 150080, China Key Laboratory of Biochemistry and Molecular Biology in Universities of Shandong Province, Weifang University , Weifang 261061, China 2Center for Inflammation and Epigenetics, Houston Methodist Research Institute, Houston, Texas. National R&D Branch Center of Surimi and Surimi Products Processing, College of Food Science and Engineering Bohai University Jinzhou China Department of Chemistry and Nano Science Ewha Womans University Seoul 120-750 Korea Department of Orthopaedics, Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi Province, China State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China and 2University of Chinese Academy of Sciences, Beijing 100049, China; State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China and 2University of Chinese Academy of Sciences, Beijing 100049, China College of Chemistry, Fuzhou University, Fuzhou, Fujian, China School of Ophthalmology & Optometry, Wenzhou Medical University, Wenzhou 325035, China; Engineering Research Center of Clinical Functional Materials and Diagnosis & Treatment Devices of Zhejiang Province, Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou 325001, China School of Nursing Nanjing Medical University Jiangsu China Research Center for Pharmaceutics, Southern Medical University, Guangzhou 510315, Guangdong Province, China. Authors' Affiliations: Department of 1Thoracic Surgery and; 3Department of Oncology, Shanghai Medical College, Fudan University; State Key Laboratory of Digital Medical Engineering School of Biological Science and Medical Engineering Southeast University Nanjing Jiangsu 210096 China Medical Center of Hematology, Xinqiao Hospital, State Key Laboratory of Trauma, Burn and Combined Injury, Army Medical University, Chongqing 400037, China Key Laboratory of Bio‐Resource and Eco‐Environment of Ministry of Education College of life sciences Sichuan University Chengdu China Department of Critical Care Medicine, Qilu Hospital (Qingdao), Cheeloo College of Medicine, Shandong University, Qingdao, Shandong 266035, P.R. China Division of Sleep Medicine, Brigham and Women’s Hospital, Boston, MA, USA; Department of Biostatistics, Harvard School of Public Health, Boston, MA, USA School of Life Sciences, Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University, Lanzhou, 730000, China Third-grade Pharmacological Laboratory on Traditional Chinese Medicine, State Administration of Traditional Chinese Medicine, China Three Gorges University, Yichang, 443002, China; College of Basic Medical Science, China Three Gorges University, Yichang, 443002, China Key Laboratory of Preclinical Study for New Drugs of Gansu Province, State Key Laboratory of Applied Organic Chemistry and Institute of Biochemistry and Molecular Biology, Lanzhou University, Lanzhou 730000, China, and Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Kowloon, Hong Kong School of Materials Science and Engineering Shanghai Tenth People's Hospital School of Medicine Tongji University Shanghai 201804 China Shilei Liu, Rui Wang, Yang Zhang, Yuan Li, Chao Cheng, Yunjian Pan, Jiaqing Xiang, Yawei Zhang, Haiquan Chen, and Yihua Sun, Fudan University Shanghai Cancer Center, Rui Wang, Yang Zhang, Yuan Li, Chao Cheng, Yunjian Pan, Jiaqing Xiang, Yawei Zhang, and Yihua Sun, Shanghai Medical College, Fudan University; Haiquan Chen, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai; and Shilei Liu, Henan Cancer Hospital, The Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, China Department of Oral and Maxillofacial-Head Neck Oncology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China.; College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai 200011, China.; Shanghai Research Institute of Stomatology, Research Unit of Oral and Maxillofacial Regenerative Medicine, Chinese Academy of Medical Sciences, Shanghai 200011, China. Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, Peopleʼs Republic of China, and College of Pharmaceutical Science, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, Peopleʼs Republic of China State Key Laboratory of Plant Cell and Chromosome Engineering Institute of Genetics and Developmental Biology Chinese Academy of Sciences Beijing China Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts; Department of Population Medicine, Harvard Pilgrim Health Care Institute and Harvard Medical School, Boston, Massachusetts Division of Nanomaterials & Chemistry Hefei National Laboratory for Physical Sciences at the Microscale Institute of Energy Hefei Comprehensive National Science Center CAS Center for Excellence in Nanoscience Institute of Biomimetic Materials & Chemistry Anhui Engineering Laboratory of Biomimetic Materials Department of Chemistry University of Science and Technology of China Hefei 230026 China College of Civil Aviation Safety Engineering, Civil Aviation Flight University of China, Guanghan 618307, China; Civil Aircraft Fire Science and Safety Engineering Key Laboratory of Sichuan Province, Deyang, Sichuan 618307, China Tianjin Key Laboratory of Materials Laminating Fabrication and Interface Control Technology, School of Material Science and Engineering, Hebei University of Technology, Tianjin, 300130, China Key Laboratory of UV-Emitting Materials and Technology of Chinese Ministry of Education, Northeast Normal University, 5268 Renmin Street, Changchun 130024, China Department of Neurology West China Hospital Sichuan University Chengdu China; West China School of Nursing Sichuan University Chengdu China College of Agronomy Northwest A&F University Yangling China; Key Laboratory of Crop Physiology and Tillage Science in Northwestern Loess Plateau Ministry of Agriculture Yangling China School of Materials Science and Engineering Zhejiang Sci‐Tech University Hangzhou 310018 China; International Scientific and Technological Cooperation Base of Intelligent Biomaterials and Functional Fibers Zhejiang Sci‐Tech University Hangzhou 310018 China; Zhejiang‐Mauritius Joint Research Center for Biomaterials and Tissue Engineering Zhejiang Sci‐Tech University Hangzhou 310018 China Department of Medical Oncology, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, Jiangsu, PR China Department of Neurosurgery, Fujian Medical University Union Hospital, Fuzhou, Fujian, People’s Republic of China; Fujian Neurosurgical Institute, Fuzhou, Fujian, People’s Republic of China State Key Laboratory of Solid Lubrication Lanzhou Institute of Chemical Physics Chinese Academy of Sciences Lanzhou 730000 China Institutes of Physical Science and Information Technology, Information Materials and Intelligent Sensing Laboratory of Anhui Province, Leibniz Joint Research Center of Materials Sciences, Engineering Laboratory of High Performance Waterborne Polymer Materials of Anhui Province, Anhui Graphene Engineering Laboratory, Key Laboratory of Structure and Functional Regulation of Hybrid Material (Ministry of Education), Anhui University, Hefei 230601, China School of Pharmacy, Soochow Medical College of Soochow University, Suzhou, Jiangsu 215123, P.R. China Department of Radiology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China Department of Obstetrics & Gynaecology, Monash University, Clayton, Australia Department of Mathematics, Michigan State University, East Lansing, Michigan 48824, United States Department of Civil and Environmental Engineering, Princeton University, Princeton, NJ 08544 New York State Psychiatric Institute, New York City (Smith, Haselden, Corbeil, Wall, Essock, Mascayano, Dixon, Olfson); Department of Psychiatry, Columbia University Vagelos College of Physicians and Surgeons, New York City (Smith, Haselden, Wall, Essock, Dixon, Olfson); Office of Performance Measurement and Evaluation, New York State Office of Mental Health, Albany (Tang, Frimpong, Goldman, Wang); Department of Psychiatry, University of California–San Francisco, San Francisco (Radigan); Department of... College of Chemistry, Liaoning University, Shenyang 110036, China; Department of Chemistry, Northeast Normal University, Changchun 130024, China School of Public Health, Zunyi Medical University, Zunyi 563000, Guizhou, P. R. China State Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology Sichuan University Chengdu People's Republic of China College of Agronomy, Ningxia University, Yinchuan 750021, China College of Animal Science and Technology, Northwest A&F University, 22 Xinong Rd, Yangling, 712100, Shaanxi, China Department of Microbiology Test, Taiyuan Center for Disease Control and Prevention, Taiyuan, People’s Republic of China Department of Population Medicine, Harvard Pilgrim Health Care Institute and Harvard Medical School, Boston, MA; Department of Biostatistics, Harvard TH Chan School of Public Health, Boston, MA Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY College of Pharmacy, Harbin Medical University - Daqing, Daqing, China Department of Medical Oncology, Jinling Hospital, School of Medicine, Nanjing University, Nanjing 210002, Jiangsu, PR China Department of Gastroenterology, West China Hospital, Sichuan University, Chengdu, China Institute of Advanced Synthesis, School of Chemistry and Molecular Engineering, Jiangsu National Synergetic Innovation Center for Advanced Materials, Nanjing Tech University, 30 South Puzhu Road, Nanjing, 211816, P. R. China Key Laboratory of Trace Element Nutrition of National Health and Family Planning Commission, National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, Beijing 100050, China. Department of Pathophysiology Naval Medical University Shanghai China Department of Gastroenterology, Nursing Section, West China Hospital, Sichuan University, Chengdu, China; Department of Radiology Peking University Third Hospital, Key Laboratory of Magnetic Resonance Imaging Equipment and Technique Beijing China Shanghai Institute of Optics and Fine Mechanics 1 Lab of High Density Optical Storage, , Chinese Academy of Sciences, Shanghai 201800, China; University of Chinese Academy of Sciences 2 , Beijing 100049, China Center for Supramolecular Chemistry & Catalysis and Department of Chemistry College of Science Shanghai University 99 Shang-Da Road Shanghai 200444 China Lakehead University, Thunder Bay, Ontario, Canada Department of Neurology The Second Affiliated Hospital of Harbin Medical University Harbin China College of Physics, Nanjing University of Aeronautics and Astronautics, Nanjing 211106, China; Key Laboratory of Aerospace Information Materials and Physics (NUAA), MIIT, Nanjing 211106, China Department of Organic Chemistry, College of Chemistry, Jilin University, Changchun 130021, People’s Republic of China Authors' Affiliations: 1Michigan Center for Translational Pathology; Departments of 2Pathology, 3Internal Medicine, 4Radiation Oncology, 5Computational Medicine and Bioinformatics, and 6Urology; 7Howard Hughes Medical Institute; 8Comprehensive Cancer Center; and 9Center for Computational Medicine and Biology, University of Michigan Medical School; 10Compendia Bioscience, Ann Arbor, Michigan; 11National Institute of Cancer Research, National Health Research Institutes, Miaoli County; and 12Department of Medical Biotechnology and Laboratory Science, Chang Gung University, Taiwan; Authors' Affiliations: 1Michigan Center for Translational Pathology; Departments of 2Pathology, 3Internal Medicine, 4Radiation Oncology, 5Computational Medicine and Bioinformatics, and 6Urology; 7Howard Hughes Medical Institute; 8Comprehensive Cancer Center; and 9Center for Computational Medicine and Biology, University of Michigan Medical School; 10Compendia Bioscience, Ann Arbor, Michigan; 11National Institute of Cancer Research, National Health Research Institutes, Miaoli County; and 12Department of Medical Biotechnology and Laboratory Science, Chang Gung University, Taiwan Key Laboratory of Pesticide and Chemical Biology (CCNU); Ministry of Education; College of Chemistry; Central China Normal University; Wuhan 430079 Department of Orthopaedics Surgery Tianjin Medical University General Hospital Tianjin China Chongqing Key Laboratory for Advanced Materials and Technologies of Clean Energy; Faculty of Materials & Energy; Southwest University; Chongqing 400715; P. R. China 6Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University, Lanzhou, China. College of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou, 310058, China State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, 430070, Wuhan, China;Foshan Xianhu Laboratory of the Advanced Energy Science and Technology Guangdong Laboratory, Xianhu Hydrogen Valley, 528200, Foshan, China The Ministry of Education (MOE) Key Laboratory for Standardization of Chinese Medicines; Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine; Shanghai China; The State Administration of TCM (SATCM) Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines; Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine; Shanghai China; Shanghai R&D Centre for Standardization of Chinese Medicines; Shanghai China Department of Biology, Lakehead University, Thunder Bay, Ontario, Canada P7B 5E1. Department of Stem Cells and Regenerative Medicine, Key Laboratory of Cell Biology, Ministry of Public Health of China, and Key Laboratory of Medical Cell Biology, Ministry of Education of China, China Medical University, Shenyang North New Area, Shenyang 110122, Liaoning, China Department of Andrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450000, China. Graduate Program in Structural and Computational Biology and Molecular Biophysics, Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030;; National Center for Macromolecular Imaging, Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030; Department of Chemistry and Applied Biosciences, ETH Zurich, Zurich CH-8093, Switzerland, and Department of Applied Chemistry, East China Institute of Technology, Fuzhou 344000, China Anhui University of Chinese Medicine Hefei 230012, China. Luohu District Chronic Disease Hospital Shenzhen China Department of Pediatric Research Institute, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatrics, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Children’s Hospital of Chongqing Medical University, Chongqing 400014, China Department of Urban Planning, School of Architecture, Tianjin University, Tianjin 300072, China Experimental Animal Center, West China Hospital, Sichuan University , Chengdu 610041 , China Shanghai Tenth People's Hospital; Tongji Hospital; School of Medicine; School of Materials Science and Engineering; Tongji University Vegetable Research Institute, Guangdong Academy of Agricultural Sciences/Guangdong Key Laboratory for New Technology Research of Vegetables, Guangzhou 510640, China Department of Chemistry, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China; Department of Bionano Technology, Hanyang University, Ansan 426-791, South Korea Key Laboratory of Green Prevention and Control of Tropical Diseases and Pests of Ministry of Education (College of Plant Protection, Hainan University), Haikou, Hainan 570228, China; Engineering Center of Agricultural Microbial Preparation Research and Development of Hainan (Hainan University), Haikou, Hainan 570228, China Office of Performance Measurement and Evaluation, New York State Office of Mental Health, New York, NY, USA. Department of Earth System Science, Ministry of Education Key Laboratory for Earth System Modeling, Institute for Global Change Studies, Tsinghua University, Beijing100084, China Department of Health Statistics, Second Military Medical University, Shanghai, China Functional Materials and Interfaces Lab, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou 215123, P. R. China Research and Development Center, Zhejiang Sucon Silicone Co., Ltd., Shaoxing 312088, China Department of Oncology, Jingmen No. 1 People’s Hospital , Jingmen , Hubei , China Dermatological Department, Dezhou People's Hospital, Dezhou, China. School of Pharmacy, Heilongjiang University of Chinese Medicine, Xiangfang District, Harbin 150040, China Department of Otolaryngology, Beijing Rehabilitation Hospital, Capital Medical University, Beijing, China Department of Obstetrics, Northwest Women and Children's Hospital No. 1616, Yanxiang Road, Yanta District, Xi'an 170061, Shaanxi, China. Beijing Key Laboratory for HIV/AIDS Research, PR China Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Solna, Sweden; The Swedish School of Sport and Health Science, GIH, Stockholm, Sweden; Wisconsin Alzheimer’s Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA Department of Pharmacy Zhengzhou University Zhengzhou 450001 China; Luohe Central Hospital Affiliated to Luohe Medical College Luohe 462000 China Xuzhou Key Laboratory of Laboratory Diagnostics, School of Medical Technology, Xuzhou Medical University , Xuzhou, China State Key Laboratory of Digital Medical Engineering, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts; Department of Population Medicine, Harvard Pilgrim Healthcare Institute and Harvard Medical School, Boston, Massachusetts Sanofi Cambridge Massachusetts USA Claude Pepper Institute and Department of Chemistry, Florida Institute of Technology, 150 West University Boulevard, Melbourne, Florida 32901-6982, United States Aging Research Center Department of Neurobiology Care Sciences and Society Karolinska Institutet‐Stockholm University Stockholm Sweden Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou 215123, P. R. China State Key Laboratory of Applied Organic Chemistry and Institute of Biochemistry and Molecular Biology, Lanzhou University, Lanzhou,730000, P. R. China Jiangsu Key Laboratory of Biofunctional Materials School of Chemistry and Materials Science Nanjing Normal University Nanjing 210023 P. R. China Department of Information Engineering Jilin Business and Technology College Changchun China Yunnan Key Laboratory of Disaster Reduction in Civil Engineering, Faculty of Civil Engineering and Mechanics, Kunming University of Science and Technology, Kunming 650500, China Department of Occupational and Environmental Health, School of Public Healthy and Management Ningxia Medical University Yinchuan People's Republic of China; Key Laboratory of Environmental Factors and Chronic Disease Control Yinchuan People's Republic of China Faculty of Materials Science and Chemistry, China University of Geosciences, Wuhan 430074, China Department of Molecular Genetics and Center for Applied Plant Science, Ohio State University, Columbus, OH 43210, USA Department of Materials Science and Engineering University of California Los Angeles CA 90095 USA School of Chemistry and Chemical Engineering, Hefei Normal University, Hefei 230601, China College of TCM, Ningxia Medical University. Department of Surgery, PuDong branch of Longhua Hospital, Shanghai University of Traditional Chinese Medicine, 1000 Shangnan road, Shanghai 200126, China State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Molecular Drug Research and KLMDASR of Tianjin, College of Pharmacy, Nankai University, Tianjin 300350, China Key Laboratory of Preclinical Study for New Drugs of Gansu Province; Lanzhou University; Lanzhou; China; School of Pharmaceutical Sciences Brigham and Women’s HospitalBoston, Massachusetts; Harvard Medical SchoolBoston, Massachusettsand Department of Physiology, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada S7N 5E5 Department of Population Medicine Harvard Pilgrim Health Care Institute and Harvard Medical School Boston Massachusetts USA; Department of Biostatistics Harvard T. H. Chan School of Public Health Boston Massachusetts USA State Key Laboratory of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu, 610041 China. Princeton University Department of Cardiology, Tangdu Hospital, The Fourth Military Medical University, Xi’an, China Department of Materials Science and Engineering, University of California, Los Angeles, California 90095, United States; California NanoSystems Institute, University of California, Los Angeles, California 90095, United States MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage School of Chemistry and Chemical Engineering State Key Lab of Urban Water Resource and Environment Harbin Institute of Technology Haerbin Shi 150090 P. R. China National Center for Nanoscience and Technology, Beijing, 100080, P. R. China Department of Neurology West China Hospital, Sichuan University Chengdu Sichuan China Department of Medical Ultrasound, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China School of Materials Science and Engineering, Zhejiang Sci-Tech University, Hangzhou, 310018, China Key Laboratory of Ministry of Education for Cell Proliferation and Differentiation, College of Life Sciences, Peking University, Beijing 100871, China Department of Radiation, China‑Japan Union Hospital of Jilin University, Changchun, Jilin 130033, P.R. China State Key Laboratory of Bioreactor Engineering, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China Department of Burn and Plastic Surgery, School of Medicine, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, China; Fujian Key Laboratory of Polymer Materials, Fujian Provincial Key Laboratory of Advanced Materials Oriented Chemical Engineering, College of Chemistry and Materials Science, Fujian Normal University, 8 Shangsan Lu, Fuzhou 350007, China National Institute for Nutrition and Food Safety, Chinese Center for Disease Control and Prevention, Beijing 100050, China. Marine College, Shandong University School of Materials Design and Engineering, Beijing Institute of Fashion Technology, No. A2, East Yinghua Street, Chaoyang District, Beijing 100029, China Yangpu Hospital, Tongji University, Shanghai 200090, China European Molecular Biology Laboratory European Bioinformatics Institute (EMBL‐EBI), Wellcome Trust Genome Campus Hinxton Cambridge UK Department of Blood Transfusion, First medical center, Chinese People’s Liberation Army General Hospital, Beijing, China; Reproductive and Genetic Center of National Research Institute for Family Planning, Beijing, 100081, China National Laboratory of Solid State Microstructures, School of Physics, and Collaborative Innovation Center for Advanced Microstructures, Nanjing University, Nanjing 210093, P. R. China Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China Special Medicine Department, Medical College, Qingdao University, Qingdao, Shandong 266071, P.R. China Department of Anesthesiology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu 221006, P.R. China Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research Department of Orthodontics College of Stomatology Xi’an Jiaotong University Xi'an China Department of Thoracic Surgery, The Third Affiliated Hospital of Chongqing Medical University, Chongqing City, 401120, PR. China. Department of Stomatology, The Affiliated Hospital of Yunnan University/The 2nd People’s Hospital of Yunnan Province, Kunming, Yunnan, China College of Chemical Engineering and Materials Science, Quanzhou Normal University, Quanzhou 362000, People’s Republic of China State Key Laboratory of Bioreactor Engineering, Shanghai Key Laboratory of Chemical Biology, and ‡Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Meilong Road 130, Shanghai 200237, China Laboratory of Nutrition and Development, Key Laboratory of Major Diseases in Children, Ministry of Education, Beijing Pediatric Research Institute, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing 100045, China Key Laboratory of Radiopharmaceuticals; College of Chemistry; Beijing Normal University; Beijing 100875; China Institute of Atomic and Molecular Physics, Sichuan University, Chengdu 610065, China; College of Chemical Engineering, Sichuan University, Chengdu 610065, China Department of Radiology, and China-Japan Union Hospital of Jilin University, Changchun, P.R. China. School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China; Key Laboratory of Preclinical Study for New Drugs of Gansu Province, Lanzhou University, Lanzhou 730000, China Molecular Biology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892; State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network School of Life Sciences, Xiamen University Fujian China Department of Sports trauma & Arthroscopy surgery, The 1st affiliated hospital of Anhui Medical University, Hefei, Anhui, People’s Republic of China School of Pharmaceutical Sciences, Liaocheng University, Liaocheng 252059, China The Second Clinical Medical School Lanzhou University Lanzhou City Gansu China Key Laboratory of the Ministry of Education for Medicinal Resources and Natural Pharmaceutical Chemistry; National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest of China; and School of Chemistry and Chemical Engineering; Shaanxi Normal University; Xi'an 710119 Department of Chemistry and Environmental Engineering, Hubei University for Nationalities, Enshi 445000, China. Guangdong Provincial Key Laboratory of Biocomputing, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences; Guangzhou Medical University, Guangzhou 510530, China Department of Epidemiology and Health Statistics, Fujian Provincial Key Laboratory of Environment Factors and Cancer, School of Public Health Fujian Medical University Fuzhou Fujian China; Fujian Key Laboratory of Tumor Microbiology Fujian Medical University Fuzhou Fujian China Chinese People's Liberation Army General Hospital Medicine Clinical Research Center Beijing China Photonics Research Center, School of Optoelectronic Engineering, Guilin University of Electronic Technology, Guilin 541004, China; Guangxi Key Laboratory of Optoelectronic Information Processing, School of Optoelectronic Engineering, Guilin University of Electronic Technology, Guilin 541004, China Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of China Chengdu 610054 China European Molecular Biology Laboratory European Bioinformatics Institute (EMBL‐EBI) Wellcome Trust Genome Campus Hinxton Cambridge UK School of Food Science and Engineering; South China University of Technology; 510640 Guangzhou; China Advanced Device Laboratory, RIKEN, 2-1 Hirosawa,Wako, Saitama 351-0198, Japan Department of Health Statistics, Faculty of Health Service Second Military Medical University Shanghai China School of Pharmaceutical Science Jiangnan University 1800 Lihu Road, Wuxi Jiangsu Province 214122 P. R. China Center of Medicine Clinical Research, Department of Pharmacy, PLA General Hospital, Beijing, China Key Laboratory of Advanced Energy Materials Chemistry (Ministry of Education) Renewable Energy Conversion and Storage Center Haihe Laboratory of Sustainable Chemical Transformations College of Chemistry Nankai University Tianjin 300071 P. R. China College of Physics and Center of Quantum Materials & Devices Chongqing University Chongqing 401331 P. R. China National Key Facility for Crop Gene Resources and Genetic Improvement (NFCRI), Institute of Crop Sciences, Chinese Academy of Agricultural Sciences (CAAS), Beijing 100081, China School/Hospital of Stomatology, Lanzhou University, Lanzhou, China From the Departments of Physiology (R.W., S.T.H., R.P.-W.) and Anatomy and Cell Biology (L. W.), University of Saskatchewan, Saskatoon, Saskatchewan, Canada; and the Laboratory of Cellular Morphology (Z. W.), Weifang Medical College, Weifang, China. Turnto Health, Brisbane, QLD, Australia School of Life Sciences, Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, China, and Department of Chemistry &Chemical Biology, Department of Medicinal Chemistry, Rutgers, The State University of New Jersey, 610 Taylor Road, Piscataway, New Jersey 08854, United States Department of Blood Transfusion, Qilu Hospital (Qingdao), Cheeloo College of Medicine Shandong University Qingdao China State Key Laboratory of Quality Research in Chinese Medicine/Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Macau, China Key Laboratory of Basic Chemistry of the National Ethnic Affairs Commission, School of Chemistry and Environment, Southwest Minzu University, First Ring Road, 4th Section No. 16, 610041 Chengdu, China Department of Radiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China Department of Thoracic Surgery, the Fourth Hospital of Hebei Medical University, Shijiazhuang, China Department of Blood Transfusion, Qilu Hospital, Shandong University, Qingdao, People's Republic of China. Department of Cardiology, Yangpu Hospital, Tongji University, Shanghai, China State Key Laboratory of Natural Medicines, Department of Physiology China Pharmaceutical University Nanjing China Department of Thoracic Surgery Shanghai Chest Hospital Shanghai Jiaotong University Shanghai China Department of Infectious Diseases Wenzhou Key Laboratory of Hepatology The First Affiliated Hospital of Wenzhou Medical University Hepatology Institute of Wenzhou Medical University Wenzhou China Department of Biomedical Sciences, City University of Hong Kong, Hong Kong, People’s Republic of China Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China Department of Hepatobiliary Surgery, Haikou People’s Hospital/Affiliated Haikou Hospital of Xiangya Medical College, Central South University, Haikou, Hainan, China School of Life Sciences Key Laboratory of Preclinical Study for New Drugs of Gansu Province School of Basic Medical Sciences & Research Unit of Peptide Science Chinese Academy of Medical Sciences, 2019RU066 Lanzhou University 199 West Donggang Road Lanzhou 730000 Gansu P. R. China; State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia Medica Chinese Academy of Medical Sciences and Peking Union Medical College 1 Xian Nong Tan Street Beijing 100050 P. R. China School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510641, China Department of Medical Oncology, Medical School of Nanjing University Affiliated Jinling Hospital, Nanjing, Jiangsu 210002, P.R. China School of Advanced Materials; Peking University Shenzhen Graduate School; Shenzhen; China From Department of Biology, Lakehead University, Thunder Bay, Ontario, Canada. Beijing National Laboratory for Condensed Matter Physics and Institute of Physics Chinese Academy of Sciences Beijing 100190 China College of Energy and Electrical Engineering, Hohai University, Nanjing 210098, China Department of Vascular Surgery, The First Affiliated Hospital, Sun Yat‑Sen University, Guangzhou, Guangdong 510080, P.R. China College of Life Science and Technology Huazhong Agricultural University Wuhan 430070 China Department of Ultrasound in Medicine, Shanghai Institute of Ultrasound in Medicine Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Xuhui District Shanghai China Department of Cardiology, Central Hospital of Yangpu Region, Tongji Medical College, Shanghai 200090, China. wangruino1@sina.com From the Department of Surgery, Division of Cardiothoracic Surgery, Emory University School of Medicine, and The Carlyle Fraser Heart Center, Atlanta, GA (K.K., S.B., A.L.K., B.L.P., N.K., C.K.N., J.WC., D.J.L.); Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan (T.M.); Medicinal Chemistry Division, NAN Laboratorios, Monterrey, Mexico (G.G., G.G.); Department of Biology, Lakehead University, Thunder Bay, ON, Canada (R.W.); Division of Cardiovascular Disease,... School of Public Health, North China University of Science and Technology, Tangshan, People’s Republic of China Ward 1, Department of Respiration, Children's Hospital of Zhengzhou (Dongsan Street Hospital), Zhengdong, Zhengzhou 450053, P.R. China Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University, Lanzhou, 730000, China; State Key Laboratory of Chiroscience, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Kowloon, Hong Kong, P. R. China Ningxia Medical University, Ningxia, People’s Republic of China; Key Laboratory of Environmental Factors and Chronic Disease Control, Ningxia, People’s Republic of China ‡Molecular Biology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892; College of Life Sciences, Yan’an University, Yan’an, China Key Laboratory of Preclinical Study for New Drugs of Gansu Province School of Basic Medical Sciences Lanzhou University Lanzhou 730000 P. R. China Research Institute of Oil Tea Camellia, Hunan Academy of Forestry, Changsha 410004, China; National Engineering Research Center for Oil-Tea Camellia, State Key Laboratory of Utilization of Woody Oil Resource, Hunan Academy of Forestry, Changsha 410116, China Department of Nephrology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China Department of Clinical pharmacology, General Hospital of the People's Liberation Army. Beijing 100853, China. Department of Materials Science and Engineering, California NanoSystems Institute, University of California, Los Angeles, California 90095, United States Key Laboratory of Smart Drug Delivery, Ministry of Education, Department of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai,China State Key Laboratory of Crop Genetics and Germplasm Enhancement, Nanjing Agricultural University , Nanjing 210095 , China; Jiangsu Province Engineering Research Center of Seed Industry Science and Technology , Nanjing 210095 , China School of Physics and Information Engineering; Shanxi Normal University; Linfen; China; Key Laboratory of Spectral Measurement and Analysis of Shanxi Province Department of Biochemistry and Molecular Biology, Heilongjiang Provincial Science and Technology Innovation Team in Higher Education Institutes for Infection and Immunity, Harbin Medical University, Harbin, 150000, China College of Veterinary Medicine, Gansu Agricultural University, Lanzhou 730070, China Department of Thoracic Surgery, Fourth Hospital of Hebei Medical University, Hebei, P.R. China Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, P.R. China State Key Laboratory of Atmospheric Boundary Layer Physics and Atmospheric Chemistry Institute of Atmospheric Physics Chinese Academy of Sciences Beijing P.R. China Department of Orthopedic Surgery and Orthopedic Research Institute, Laboratory of Stem Cell and Tissue Engineering, State Key Laboratory of Biotherapy, West China Hospital Sichuan University Chengdu Sichuan China Department of Population Medicine , Harvard Pilgrim Health Care Institute and Harvard Medical School , Boston , USA; Department of Biostatistics , Harvard T. H. Chan School of Public Health , Boston , USA Department of Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China Engineering Research Center of Nano-Geomaterials of Ministry of Education; Faculty of Material and Chemistry; China University of Geosciences; Wuhan 430074; China The Centre of Nanoscale Science and Technology and Key Laboratory of Functional Polymer Materials, Institute of Polymer Chemistry, College of Chemistry and Renewable Energy Conversion and Storage Center (RECAST), Nankai University, Tianjin 300071, China State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory of Oral Biomedicine (Ministry of Education), School and Hospital of Stomatology, Wuhan University, Wuhan, 430072, China 15Bristol Myers Squibb, Princeton, New Jersey. Beijing Engineering Research Center of Protein and Antibody, Sinocelltech Ltd. Beijing China College of Food Science, Northeast Agricultural University, Harbin, Heilongjiang 150030, China Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center College of Marine Sciences, Shanghai Ocean University, Shanghai 201306, China. Polar Marine Ecosystem Group, Ministry of Education Key Laboratory of Sustainable Exploitation of Oceanic Fisheries Resources, Shanghai Ocean University, Shanghai 201306, China. Department of Materials Science and Engineering and California NanoSystems Institute University of California Los Angeles CA 90095 USA Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital; Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, People’s Republic of China; Graduate School of Chinese Academy of Sciences, Beijing 100049, People’s Republic of China Department of Chemical Engineering and ‡Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States Anhui Key Laboratory of Tissue Transplantation, The First Affiliated Hospital of Bengbu Medical College, Bengbu, P.R. China College of Chemistry, Fuzhou University, Fuzhou 350116, Fujian, China. China Food Flavor and Nutrition Health Innovation Center, Beijing Technology and Business University, Beijing 100048, China; School of Light Industry, Beijing Technology & Business University, Beijing 100048, China Department of Medical Oncology, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, Jiangsu, China Key Laboratory of Hainan Trauma and Disaster Rescue, Department of Wound Repair, The First Affiliated Hospital of Hainan Medical University, Hainan Medical University, Haikou 571199, China; Engineering Research Center for Hainan Bio-Smart Materials and Bio-Medical Devices, Key Laboratory of Emergency and Trauma, Ministry of Education, Key Laboratory of Hainan Functional Materials and Molecular Imaging, College of Emergency and Trauma, Hainan Medical University, Haikou 571199, China Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, China Key Laboratory of Preclinical Study for New Drugs, of Gansu Province School of Basic Medical Sciences Lanzhou University 199 West Donggang Road, Lanzhou 730000 China Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences Lanzhou University Lanzhou China College of Pharmaceutical Sciences Zhejiang University Hangzhou China; Department of Pharmacology Key Laboratory of Ministry of Education in Fertility Preservation and Maintenance Ningxia Medical University Yinchuan China Department of Chemical and Biological Engineering The Hong Kong University of Science and Technology Hong Kong SAR 999077 China 2Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, New York. Division of Sleep and Circadian Disorders, Brigham & Women's Hospital, Harvard Medical School, Boston, MA Aging Research Center and Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet-Stockholm University, Stockholm, Sweden; Swedish School of Sport and Health Sciences (GIH), Stockholm, Sweden Department of Urology Nanjing Medical University Nanjing Jiangsu China Southeast Sichuan Geological Group, Chongqing Bureau of Geology and Minerals Exploration, Chongqing 400038, China. Chongqing Key Laboratory of Land Quality Geological Survey, Chongqing 400038, China. Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, Beijing 100083, China State Key Laboratory for Mesoscopic Physics and Frontiers Science Center for Nano-Optoelectronics, School of Physics, Peking University, Beijing 100871, China School of Pharmaceutical Sciences, Capital Medical University, Beijing 100069, P. R. China Department of Pathology, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA College of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang 150040, China; Jiangsu Collaborative Innovation Center of Biomedical Functional Materials and Jiangsu Key Laboratory of Bi-functional Materials; School of Chemistry and Materials Science; Nanjing Normal University; Nanjing; P. R. China College of Engineering, Zhejiang A&F University, Hangzhou, Zhejiang 311300, China Department of Pharmacology College of Pharmacy, Ningxia Medical University Yinchuan China Department of Thoracic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, Guangdong 510006, People's Republic of China Department of Neurosurgery, Affiliated Union Hospital of Fujian Medical University, Fuzhou, China State Key Laboratory of Animal Biotech Breeding, National Engineering Laboratory for Animal Breeding, Key Laboratory of Animal Genetics, Breeding and Reproduction of the Ministry of Agriculture and Rural Affairs, College of Animal Science and Technology, China Agricultural University, No. 2 Yuanmingyuan West Road, Beijing 100193, China Robinson Research Institute and Adelaide Medical School, University of Adelaide, North Adelaide, Australia. Centre for Medical Genetics & Hunan Key Laboratory of Medical Genetics, School of Life Sciences, Central South University , Changsha , Hunan , China Department of Orthopedics, Nanjing Integrated Traditional Chinese and Western Medicine Hospital, Nanjing, 210014, China. mayong00506@163.com. Department of Medical Oncology, First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui, China Key Laboratory of Green Chemistry and Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu, Sichuan 610064, P. R. China Department of Chemistry, The University of Texas at San Antonio, San Antonio, Texas 78249, United States College of Food and Pharmaceutical Engineering, Guiyang University, Guiyang 550005, China Office of Disease Control and Emergency Response, Chinese Center for Disease Control and Prevention, Beijing 100050, China. Division of Sleep and Circadian Disorders Brigham and Women's Hospital Boston MA USA; Department of Biostatistics Harvard T.H. Chan School of Public Health Boston MA USA College of Marine Sciences, Shanghai Ocean University, Shanghai 201306, China Departments of Anatomy and Cell Biology and Physiology, College of Medicine, and College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, SK, Canada S7N 5E5; and Plant Biotechnology Institute, National Research Council, Saskatoon, SK, Canada SW9 OW9 Brigham and Women's Hospital, 1861, Division of Sleep, Circadian, and Respiratory Neurobiology, Boston, Massachusetts, United States; Harvard Pilgrim Health Care Inc, 19392, Population Medicine , Boston, Massachusetts, United States; Harvard Medical School, Boston, Massachusetts, United States Department of Neuroscience, Physiology and Pharmacology, UCL, London WC1E 6BT, UK School of Textile and Garment, Anhui Polytechnic University, Wuhu 241000, China Authors' Affiliations: 1Department of Medical Oncology, Nanjing Medical University Affiliated Cancer Hospital of Jiangsu Province, Cancer Institution of Jiangsu Province; 2Department of Medical Oncology, Jinling Hospital, School of Medicine, Nanjing University; and 3Department of Oncology, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, PR China Department of Materials Science and Engineering and California Nano System Institute University of California Los Angeles CA 90095 USA School of Manufacturing Science and Engineering, Sichuan University, First Ring Road, No. 24, Chengdu, Sichuan 610065, China Division of Chemistry, Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390, United States Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, Harvard Medical School State Key Laboratory of Geological Processes and Mineral Resources, and Institute of Earth Sciences, China University of Geosciences, Beijing 100083, China. Department of Dermatology Peking University First Hospital Beijing China; National Clinical Research Center for Skin and Immune Diseases Beijing China; Beijing Key Laboratory of Molecular Diagnosis on Dermatoses Beijing China; NMPA Key Laboratory for Quality Control and Evaluation of Cosmetics Beijing China Changchun University of Science and Technology, School of Compute Science and Technology, Changchun, Jilin 130022, China Department of Anesthesiology, HanDan Central Hospital, Hebei, China. Harvard Medical School, Boston, MA 02115, USA.; Department of Population Medicine, Harvard Pilgrim Health Care Institute, Boston, MA 02215, USA. Department of Thoracic Surgery The Fourth Hospital of Hebei Medical University Shijiazhuang China Department of Surgery, Case Western Reserve University, Cleveland, OH 44106, USA; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106, USA; Department of Surgery, Division of Surgical Oncology, University Hospitals Cleveland Medical Center, Cleveland, OH 44106, USA Faculty of Material and Chemistry China University of Geosciences Wuhan 430074 P. R. China Department of Drug Clinical Trial PLA General Hospital Beijing 100853 China Key Laboratory of Preclinical Study for New Drugs of Gansu Province, Institute of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, China Department of Neurology, Dushu Lake Hospital Affiliated to Soochow University , Suzhou City, Jiangsu Province, China Ministry of Land and Resources Key Laboratory of Metallogeny and Mineral Assessment, Institute of Mineral Resources Chinese Academy of Geological Sciences, Beijing 100037, China. Department of Critical Care Medicine Chengdu University of Traditional Chinese Medicine State Key Laboratory of Southwestern Chinese Medicine Resources, College of Pharmacy, , Chengdu 611137 , China Department of Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China Department of Neurosurgery, Fujian Medical University Union Hospital, Fujian Institute of Neurosurgery, Fuzhou, Fujian Province, China Key Laboratory of Synthetic Chemistry of Natural Substances, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China, and State Key Laboratory of Applied Organic Chemistry and Institute of Biochemistry and Molecular Biology, Lanzhou University, Lanzhou 730000, China Shenzhen Center for Chronic Disease Control, Shenzhen 518020, China. zhenjin.1983@163.com Ministry of Health Key Laboratory of Radiobiology, School of Public Health, Jilin University, Changchun, China Division of Sleep Medicine, Brigham and Women's Hospital; University of Pennsylvania, Philadelphia, PA; Department of Biostatistics, Harvard School of Public Health; University of Pennsylvania, Philadelphia, PA Tianjin University of Traditional Chinese Medicine, Tianjin, China. Department of Gynaecology and Obstetrics, Heping Hospital Affiliated to Changzhi Medical College, Changzhi 046000, Shanxi, PR China Department of Clinical Pharmacology, PLA General Hospital, Beijing 100853, People's Republic of China Department of Foot and Ankle Surgery Xiangyang Hospital of Traditional Chinese Medicine (The Affiliated Orthopedics & Traumatology Hospital of Hubei University of Traditional Chinese Medicine) Xiangyang China Department of Neurology, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150086, P.R. China Department of Nursing, Linyi People’s Hospital, Linyi, Shandong, China (mainland) Department of Biomedical Engineering, Technion—IIT, Haifa, 32000, Israel Shanghai Key Laboratory of New Drug Design School of Pharmacy East China University of Science and Technology Shanghai 200237 China Department of Dermatology of First Affiliated Hospital and Institute of Dermatology Anhui Medical University Hefei China; Key Laboratory of Dermatology (Anhui Medical University) Ministry of Education Hefei China Department of Special Ward, Tianjin Second People’s Hospital, Tianjin, 300192, PR China State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, People's Republic of China, and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, People's Republic of China College of Chemistry and Molecular Engineering Zhengzhou University Zhengzhou 450001 China Department of Chemical and Biological Engineering, The Hong Kong University of Science and Technology, Hong Kong, SAR, China Department of Blood Transfusion, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310009, Zhejiang Province, China. Tianjin State Key Laboratory of Modern Chinese Medicine Tianjin University of Traditional Chinese Medicine Tianjin China National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention; Key Laboratory of Trace Element Nutrition, National Health Commission of the People's Republic of China, Beijing 100050, China. Zhejiang Province Key Laboratory of Smart Materials, Key Laboratory of Biomass Chemical Engineering of Ministry of Education, and College of Chemical and Biological Engineering, ZJU-Hangzhou Global Scientific and Technological Innovation Center, Zhejiang University, Hangzhou, Zhejiang, 310027, China Department of Neurosurgery, Shanghai East Hospital, School of Medicine, Tongji University, 150 Jimo Road, Shanghai 200120, China Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry, Center for Excellence in Molecular Synthesis of CAS, University of Science and Technology of China, 96 Jinzhai Road, Hefei 230026, China Laboratory of Molecular Neuropathology, Jiangsu Key laboratory of Neuropsychiatric Disorders and Department of Pharmacology, College of Pharmaceutical Sciences Soochow University Suzhou Jiangsu China Department of Chemistry, ‡Department of Physics and Astronomy, University of Kansas, Lawrence, KS, USA 66045. Institutes of Physical Science and Information Technology, Engineering Laboratory of High Performance Waterborne Polymer Materials of Anhui Province, Leibniz Research Center for Materials Science, Anhui Graphene Engineering Laboratory, Key Laboratory of Structure and Functional Regulation of Hybrid Material (Ministry of Education), Anhui University, Hefei 230601, China Key Laboratory of Advanced Metallic Materials of Jiangsu Province, School of Materials Science and Engineering, Southeast University, Nanjing 211189, P. R. China 1Special Medicine Department, College of Basic Medicine, Qingdao University, Qingdao, China Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of China Chengdu 610054 Sichuan China From the Aging Research Center (R.W., L.F., E.J.L., M.L., G.K., L.K., A.S., L.B., C.Q.), Department of Neurobiology, Care Sciences and Society, Karolinska Institutet–Stockholm University; Stockholm Gerontology Research Center (L.F., L.B.); and Division of Neurogeriatrics (C.G.), Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Center for Alzheimer Research at Karolinska Institutet, Sweden. Medical Oncology Department of Jinling Hospital, Medical School of Nanjing University, Nanjing, People's Republic of China. College of Animal Science and Technology Nanjing Agricultural University Nanjing China Translational Medical Center, PLA General Hospital, 28 Fu Xing Road, Beijing 100853, China L. Zheng, R. Wang, H. Erfle, H. Voss, W. Ansorge, F. C. Kafatos, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany.; A. J. Cornel and F. H. Collins, Centers for Disease Control and Prevention, 4770 Buford Highway, Mail Stop F22, Chamblee, GA 30341, USA. Department of Psychiatry, Columbia University Vagelos College of Physicians and Surgeons, New York City (Patel, Messner, Dixon, Simpson); Research Foundation for Mental Hygiene, New York State Psychiatric Institute, New York City (Patel, Dixon, Simpson); New York State Office of Mental Health, Albany (Radigan, Sang, Wang, Gu, Myers). Institute of Physics, Chinese Academy of Sciences, Beijing, 100190, China School of Life Sciences Nantong University Nantong China Harbin Institute of Technology Shenzhen Graduate School 1 , Shenzhen, Guangdong, China Beijing Protein and Antibody R&D Engineering Center Sinocelltech Ltd. Beijing 100176 P. R. China Department of Obstetrics and Gynaecology, School of Clinical Sciences at Monash Health Monash University Melbourne Victoria Australia National Laboratory of Solid State Microstructures, School of Physics, Nanjing University, Nanjing 210093, China School of Nursing and Rehabilitation Shandong University Jinan China College of Life Science and Technology Huazhong Agricultural University Wuhan China; Technology Center, Enshi State Tobacco Cooperation Hubei Province Tobacco CO., Ltd. Enshi China Key Laboratory of Preclinical Study for New Drugs of Gansu Province, Institute of Biochemistry and Molecular Biology, State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000 China; State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000 China Department of Orthopaedics, The Affiliated Wuxi People’s Hospital of Nanjing Medical University, Wuxi 214000, China Department of Digestive Diseases, Huashan Hospital, Fudan University, 12 Middle Wulumuqi Road, Shanghai 200040, China; Department of Immunology of Shanghai Medical School and Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, China Department of Pathobiological Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, Louisiana, USA Non-coding RNA and Drug Discovery Key Laboratory of Sichuan Province, Chengdu Medical College, Chengdu, Sichuan, China School of Flexible Electronics (Future Technologies) Nanjing Tech University Nanjing 211816 P. R. China Institutes of Physical Science and Information Technology, Key Laboratory of Structure and Functional Regulation of Hybrid Material, Leibniz Research Center of Materials Science, Anhui University, Hefei 230039, China Beijing Key Laboratory of Energy Conversion and Storage Materials, College of Chemistry, Beijing Normal University, Beijing 100875, China Department of Chemistry and Nanoscience, Ewha Womans University, Seoul 03760, Republic of Korea Department of Microbiota Medicine, Medical Center for Digestive Diseases, The Second Affiliated Hospital of Nanjing Medical University, Nanjing 210011, China; Key Lab of Holistic Integrative Enterology, Nanjing Medical University, Nanjing 210011, China Department of Medical Oncology, Nanjing University, Nanjing, China Molecular Design and Synthesis, Department of Chemistry, KU Leuven Medical Center of Hematology the Second Affiliated Hospital Army Medical University Chongqing China; State Key Laboratory of Trauma Burn and Combined Injury Army Medical University Chongqing China International Center for Quantum Materials, School of Physics, Peking University, Beijing 100871, People’s Republic of China Department of Biology Lakehead University and Thunder Bay Regional Research Institute Thunder Bay ON Canada Department of Chemistry Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials State Key Laboratory of Molecular Engineering of Polymers and iChem Fudan University Shanghai 200433 P. R. China Institutes of Physical Science and Information Technology Anhui University Hefei 230601 P. R. China Division of Vascular Surgery Guangdong Key Engineering Laboratory for Diagnosis and Treatment of Vascular Disease First Affiliated Hospital Sun Yat‐sen University Guangzhou China Department of Critical Care Medicine, Shengjing Hospital of China Medical University Shenyang 110004, People's Republic of China. State Key Laboratory of Protein and Plant Gene Research, School of Life Sciences, Peking University, Beijing, China Department of Nuclear Medicine, Affiliated Hospital of Zunyi Medical University, Zunyi, China State Key Laboratory of Tree Genetics and Breeding Northeast Forestry University Harbin China Division of Life Science, Molecular Neuroscience Center, State Key Laboratory of Molecular Neuroscience, Hong Kong University of Science and Technology; Clear Water Bay Kowloon Hong Kong New York State Office of Mental Health, Albany, NY Key Laboratory of Preclinical Study for New Drugs of Gansu Province, Institute of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Lanzhou University, China; State Key Laboratory of Chiroscience, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Kowloon, Hong Kong Department of Ultrasound, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China (Z.S., L. Fang, Y.X., L.H., Q.L., B.W., J.W., R.W., C.W., Y.Y., H.Y., D.Z., Y.Z., L.Z., M.X.).; Hubei Province Key Laboratory of Molecular Imaging, Wuhan, China (Z.S., L. Fang, Y.X., L.H., Q.L., B.W., J.W., R.W., C.W.,Y.Y., H.Y., D.Z., Y.Z., L.Z., M.X.). Department of Chemistry and Nanoscience Ewha Womans University Seoul 03706 Republic of Korea State Key Laboratory of Applied Organic Chemistry Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province College of Chemistry and Chemical Engineering Lanzhou University Lanzhou 730000 China Key Laboratory of Advanced Energy Materials Chemistry (Ministry of Education), College of Chemistry, Nankai University, Tianjin 300071, P. R. China Department of Physiology, University of Saskatchewan, Saskatoon, Saskatchewan S7N 5E5; and Department of VIP and Geriatrics, Xi'an Gaoxin Hospital, Gaoxin Industrial Development Distinct, Xi'an, Shanxi 710075, P.R. China Department of Endocrinology, Genetic and Metabolism, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing 100045, China Department of Rehabilitation, Shanghai East Hospital, Tongji University, Shanghai, China Beijing National Laboratory for Condensed Matter Physics; Institute of Physics; Chinese Academy of Sciences; Beijing 100190, China Department of Chemistry and Nanoscience; Ewha Womans University; Seoul; Korea Department of Electrocardiography, People's Hospital of Yuxi, Yuxi, Yunnan 653100, China. Metabolism Unit, National Institute on Aging, National Institutes of Health , Baltimore, MD , USA. College of Agronomy Ningxia University Yinchuan China; Ningxia Grape and Wine Research Institute Yinchuan China; China Wine Industry Technology Institute Yinchuan China Key Laboratory of Life-Organic Analysis, Key Laboratory of Pharmaceutical Intermediates and Analysis of Natural Medicine, College of Chemistry and Chemical Engineering, Qufu Normal University, Qufu 273165, China; Key Laboratory of Coastal Environmental Processes and Ecological Remediation, Research Center for Coastal Environmental Engineering Technology of Shandong Province, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China Department of Neurology, First Hospital, Shanxi Medical University, Shanxi, China Authors' Affiliations: Departments of 1Thoracic Surgery and 2Pathology, Fudan University Shanghai Cancer Center; 3Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China; and 4Vanderbilt-Ingram Cancer Center, Nashville, Tennessee; Authors' Affiliations: Departments of 1Thoracic Surgery and 2Pathology, Fudan University Shanghai Cancer Center; 3Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China; and 4Vanderbilt-Ingram Cancer Center, Nashville, Tennessee College of Chemistry and Materials Engineering Zhejiang Agriculture & Forestry University Hangzhou Zhejiang Province 311300 China Department of Thoracic Surgery, The Fourth Hospital of Hebei Medical University , Shijiazhuang, Hebei , China Key Laboratory of Preclinical Study for New Drugs of Gansu Province, Institute of Biochemistry and Molecular Biology, State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, China, Department of Chemistry and Chemical Biology, University of New Mexico, Albuquerque, New Mexico 87131-0001, United States, and Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 20203, China College of Pharmacy, Guilin Medical University, Guilin, China Department of Pathology, The Fourth Affiliated Hospital of China Medical University, Shenyang - China Clemson Univ. College of Materials Science and Engineering Nanjing Tech University Nanjing 211816 P. R. China Department of Biochemistry and Molecular Biology, Third Military Medical University, Chongqing 400038, China |
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