author/MD5_b79004852c791b2dffd64a2f00a805b4

http://rdf.ncbi.nlm.nih.gov/pubchem/author/MD5_b79004852c791b2dffd64a2f00a805b4

Outgoing Links

Predicate	Object
family-name	Li Yue Li
name	Yue. Li Yue Li
given-name	Yue Yue.
organization-name	Department of Epidemiology and Biostatistics, Dornsife School of Public Health, Drexel University, Philadelphia, Pennsylvania. Key Laboratory of Vegetation Restoration and Management of Degraded Ecosystems & CAS Engineering Laboratory for Vegetation Ecosystem Restoration on Islands and Coastal Zones South China Botanical Garden, Chinese Academy of Sciences Guangzhou China; South China National Botanical Garden Guangzhou China; Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou) Guangzhou China; Guangdong Provincial Key Laboratory of Applied Botany South China Botanical Garden Guangzhou China Department of Epidemiology and Biostatistics, Key Laboratory of Environmental Health of Ministry of Education, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China Department of Otorhinolaryngology‐Head and Neck Surgery The Third Affiliated Hospital of Sun Yat‐Sen University Guangzhou China Laboratory of Genetics and Breeding of Marine Organism, College of Marine Life Sciences, Ocean University of China, Qingdao, People’s Republic of China; Key Laboratory of Food Colloids and Biotechnology, Ministry of Education, School of Food Science and Technology, Jiangnan University, Wuxi 214122, People’s Republic of China State Key Laboratory of Heavy Oil Processing, School of Materials Science and Engineering, College of Science, China University of Petroleum (East China), Qingdao 266580, P. R. China Department of Chemical Engineering and Materials Science, Stevens Institute of Technology, Hoboken, New Jersey 07030, United States From the Departments of Internal Medicine and Cardiovascular Research Center (Z.G., T.P.R., Y.L., W.K., O.M.K, Y.W., D.D.H., M.A.J., P.D.S., A.P., K.Z., R.M.W., L.-S.S., M.E.A.) and Molecular Physiology and Biophysics (T.P.R., M.E.A.), Carver College of Medicine, University of Iowa, Iowa City, IA; Department of Physiology, University of California, Los Angeles, CA (K.D.P.); and Departments of Biomedical Engineering and Internal Medicine, The Ohio State University, Columbus, OH (X.-Q.W, T.J.H.). State Key Laboratory of Crop Gene Exploration and Utilization in Southwest China Sichuan Agricultural University Chengdu China; Triticeae Research Institute, Sichuan Agricultural University Chengdu China Sports Medicine Service, Beijing Jishuitan Hospital, Xi Cheng District, Beijing, China Department of Anaesthesia Tianjin Medical University Cancer Institute and Hospital, Key Laboratory of cancer prevention and therapy Tianjin China; National Clinical Research Center for Cancer Tianjin China Laboratory of Clinical Pharmacokinetics Shuguang Hospital Affiliated with the Shanghai University of Traditional Chinese Medicine Shanghai China Department of Computer Science, University of Toronto, Toronto, Ontario M5S 3G4, Canada; The Donnelly Centre, University of Toronto, Toronto, ON M5S 3E1, Canada Department of Cardiology, The First Affiliated Hospital of Harbin Medical University, Harbin Medical University, Harbin, P.R. China; Institute of Metabolic Disease, Heilongjiang Academy of Medical Science, Harbin, P.R. China; Heilongjiang Key Laboratory for Metabolic Disorder & Cancer Related Cardiovascular Diseases, Harbin, P.R. China Department of Orthopedic Surgery, Beijing Chao-Yang Hospital, Capital Medical University; Department of Gastroenterology Sir Run Run Shaw Hospital Zhejiang University Medical School Hangzhou China; Institute of Gastroenterology Zhejiang University (IGZJU) Hangzhou China i-Lab, Key Laboratory of Multifunctional Nanomaterials and Smart Systems, Suzhou Institute of Nano-Tech and Nano-Bionics (SINANO), Chinese Academy of Sciences (CAS), 398 Ruoshui Road, Suzhou, Jiangsu 215123, P. R. China National Engineering Laboratory for Forest Tree Breeding Key Laboratory for Genetics and Breeding of Forest Trees and Ornamental Plants of Ministry of Education Beijing Forestry University Beijing 100083 China Department of Chemistry, University of Southern California, Los Angeles California 90089, United States Department of Electronic Engineering, Tsinghua University, Beijing 100084, China.; Department of Electrical and Systems Engineering, University of Pennsylvania, Philadelphia, PA 19104, USA. School of Public Health, Qingdao University, Qingdao 266021, China; Institute of Nutrition and Health, Qingdao University, Qingdao 266021, China College of Chemistry and Environmental Science, Henan Normal University, 46 Jianshe Street, Xinxiang, 453007 Henan, People’s Republic of China, and Key Lab of Materials Physics, Anhui Key Laboratory of Nanomaterials and Nanotechnology, Institute of Solid State Physics, Chinese Academy of Sciences, Hefei, 230031 Anhui, People’s Republic of China Beijing Key Laboratory of Big Data Technology for Food Safety, Beijing Technology and Business University, Beijing 100048, China; Key Laboratory of Internet and Big Data for China Light Industry, Beijing Technology and Business University, Beijing 100048, China College of Veterinary Medicine, China Agricultural University, Beijing, China; and College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, P. R. China School of Computer Science , McGill, Montreal, QC H3A 0E9, Canada Key Laboratory for Geophysical Instrument of Ministry of Education, Jilin University , Changchun 130061, and , Changchun 130061, China; China , Changchun 130061, and , Changchun 130061, China; College of Instrumentation and Electrical Engineering, Jilin University , Changchun 130061, and , Changchun 130061, China Department of Chemistry, Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Tsinghua University, Beijing 100084, China Nanotechnology Research Institute (NRI), National Institute of Advanced Industrial Science and Technology (AIST), Central 5, 1-1-1 Higashi, Tsukuba, Ibaraki 305-8565, Japan Key Laboratory of Materials Physics Institute of Solid State Physics HFIPS Chinese Academy of Sciences Hefei 230031 China State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China Waisman Center, University of Wisconsin-Madison, Madison, WI 53705, USA.; Department of Neuroscience, University of Wisconsin-Madison, Madison, WI 53705, USA. Department of Chemistry and Chemical Engineering, College of Science, Northeast Forestry University, Harbin 150040, P. R. China Department of Dermatology Huashan Hospital of Fudan University Shanghai China State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China; Key Laboratory of Preventive Veterinary Medicine in Hubei Province, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China Department of Food Science and Engineering, Institute of Food Safety and Nutrition, Guangdong Engineering Technology Center of Food Safety Molecular Rapid Detection, Jinan University, Guangzhou 510632, China Department of Ultrasound Medicine, Laboratory of Ultrasound Molecular Imaging, The Third Affiliated Hospital of Guangzhou Medical University, The Liwan Hospital of the Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, 510150, China Department of Anesthesiology the First Affiliated Hospital of Harbin Medical University Harbin China State Key Laboratory of Food Nutrition and Safety, College of Food Science and Engineering, Tianjin University of Science & Technology, Tianjin, 300457, China Department of Cardiovascular Surgery Xijing Hospital The Fourth Military Medical University Xi'an China Yunnan Provincial Key Laboratory of Molecular Biology for Sinomedicine, Yunnan University of Traditional Chinese Medicine, 1076, Yuhua Rd., Kunming 650500, China Laboratory of Translational Medicine, Jiangsu Province Academy of Traditional Chinese Medicine Nanjing, Jiangsu ProvinceP.R. China Department of Traditional Chinese Medicine, The Third Affiliated Hospital of Sun Yet‑sen University, Guangzhou, Guangdong 510000, P.R. China Guangzhou University of Chinese Medicine Institute of Biomechanics and Medical Engineering, Department of Engineering Mechanics, Tsinghua University, Beijing 100084, China Department of Microbiology and Immunology, University of Western Ontario, London, ON, Canada State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China; School of Food Science and Technology, Jiangnan University, Wuxi 214122, China Guangdong Provincial Key Laboratory of Proteomics, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China. Ultrasound Department of Chinese PLA General Hospital Beijing China College of Life Sciences, Jilin Agricultural University, Changchun 130118, China Neurosurgery Department, 451 Hospital of Chinese People's Liberation Army, Xi'an 710054, China. SKL-ESPC and BIC-ESAT, College of Environmental Sciences and Engineering, Peking University, Beijing 100871, China State Key Laboratory of Pollution Control and Resource Reuse, Key Laboratory of Yangtze River Water Environment, Ministry of Education, College of Environmental Science and Engineering, Tongji University, Shanghai, People’s Republic of China Department of Pharmacy, School of Medicine, Shenzhen University, Shenzhen 518060, China Department of Nephrology, Hongqi Hospital, Mudanjiang Medical University, 5 Tongxiang Road, Aimin District, Mudanjiang 157011, Heilongjiang, China College of Chemistry; Nankai University; Tianjin 300071; China; Key Laboratory of Advanced Energy Materials Chemistry (Ministry of Education) Basic Medical College, Jiamusi University, Jiamusi, Heilongjiang 154007, P.R. China Department of Orthopedics, The Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi 710004, P.R. China Anhui Key Laboratory of Bioactivity of Natural Products, School of Pharmacy Anhui Medical University Hefei Anhui China Departments of Psychiatry (Maeng, Tsun, Lesch, Jacobowitz, Weisman, Lamberti), Biostatistics and Computational Biology (Strawderman, Harrington), and Public Health Sciences (Li), University of Rochester Medical Center, Rochester, New York. Division of Health Policy and Outcomes Research, Department of Public Health Sciences, University of Rochester School of Medicine and Dentistry, Rochester, NY Key Laboratory of Signal Detection and Processing, College of Computer Science and Technology, Xinjiang University, Urumqi 830046, China Department of Microbiology and Immunology, Western University, London, Canada Department of Oncology, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, China School of Psychological and Cognitive Sciences and Beijing Key Laboratory of Behavior and Mental Health, Peking University, Beijing 100871, China; PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing 100871, China Department of Hepatobiliary Surgery, Second Affiliated Hospital, Chongqing Medical University, Chongqing 400010, China. Division of Pulmonary and Critical Care Medicine, Department of Medicine University of Maryland School of Medicine Baltimore Maryland USA Department of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, 100730 Beijing, China. National Engineering Research Center of Electromagnetic Radiation Control Materials and State Key Laboratory of Electronic Thin Films and Integrated Devices, School of Microelectronics and Solid State Electronics, University of Electronic Science and Technology of China, Chengdu 610054, People’s Republic of China College of Chemistry and Chemical Engineering Central South University Changsha 410083 China Yue Li is a professor in the Department of Public Health Sciences, University of Rochester. Bio-Rad (Shanghai) Life Science Research and Development Co., Ltd, Shanghai, China Department of General Surgery, Third Xiangya Hospital, Central South University, Changsha 410013, China. 2437065850@qq.com. School of Physics and Electronic Engineering; Linyi University; Linyi 276005; P. R. China; State Key Lab of Superhard Materials College of Food Science and Engineering, Ocean University of China Institute for Advanced Interdisciplinary Research (iAIR) School of Chemistry and Chemical Engineering University of Jinan Jinan 250022 P. R. China 1Department of Endocrinology, Shanghai Fifth People’s Hospital affiliated to Fudan University, Minhang District, Shanghai, People’s Republic of China School of Metallurgy and Environment Central South University Changsha 410083 P. R. China; Engineering Research Center of the Ministry of Education for Advanced Battery Materials Central South University Changsha 410083 China Business School, Sichuan University, Chengdu, China Department of Pediatrics, Jiangsu Women & Children Health Hospital, Nanjing, 210036, China Department of Cardiology the First Affiliated Hospital Harbin Medical University Harbin China Department of Anesthesiology The Central Hospital of Enshi Tujia and Miao Autonomous Prefecture Enshi Hubei China Department of Microbiology and Center of Infectious Disease, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China i-Lab, Key Laboratory of Multifunctional Nanomaterials and Smart Systems, Suzhou Institute of Nano-Tech and Nano-Bionics (SINANO), Chinese Academy of Sciences (CAS), 398 Ruoshui Road, Suzhou 215123, China; School of Nano-Tech and Nano-Bionics, University of Science and Technology of China, 96 Jinzhai Road, Hefei, Anhui 230026, China Department of Polymeric Materials & Engineering College of Materials & Metallurgy Guizhou University, Huaxi District Guiyang 550025 China Department of Nursing, Yantai Yuhuangding Hospital, Yantai, Shandong, Shandong, China School of Materials and Chemical Engineering, Henan University of Engineering, Zhengzhou, Henan 451191, China Department of Gastroenterology Peking Union Medical College Hospital Beijing China Department of Biological Sciences Center for Stem Cells and Regenerative Medicine, Center for Zebrafish Research, University of Notre Dame Notre Dame IN 46556 USA Department of Cardiology, the First Affiliated Hospital of Harbin Medical University, No. 23 Youzheng Street, Nangang District, Harbin, Heilongjiang Province, China 150001. xuejingyi2013@163.com or ly99ly1972@163.com. Department of Pharmacology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, China Department of Neurosurgery (H.S., Y. Li, A.X., C.Y., L.M., Y. Liu.), West China Hospital, Sichuan University, Chengdu, China. i-Lab; Suzhou Institute of Nano-Tech and Nano-Bionics (SINANO); Chinese Academy of Sciences (CAS); Suzhou; P. R. China Department of Public Health Sciences, University of Rochester School of Medicine and Dentistry, Rochester, New York Xinan Hospital, Army Medical University, 400038 Chongqing, People’s Republic of China School of Materials Science and Engineering College of Science China University of Petroleum (East China) NO. 66, Changjiang Road West Qingdao, Shandong 266580 P.R. China College of Animal Science and Technology Nanjing Agricultural University Nanjing China Department of Cardiology, the First Affiliated Hospital of Harbin Medical University, Harbin, China. Department of Radiation Oncology, Shanghai Chest Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200030, China Sports Medicine Service, Beijing Jishuitan Hospital, Beijing 100035, China. Department of Cardiovascular Surgery Air Force Medical Center Beijing China State Key Laboratory of Pathogen and Biosecurity, Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences (AMMS), Beijing 100071, China Department of Experimental Research State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Sun Yat‐sen University Cancer Center Guangzhou China 4Department of General Surgery, Shandong Qianfoshan Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China. Laboratory of Stem Cells and Tissue Engineering, College of Basic Medicine Chongqing Medical University Chongqing China; Department of Histology and Embryology, College of Basic Medicine Chongqing Medical University Chongqing China Department of Intensive Care Medicine, The Second Affiliated Hospital of Harbin Medical University , Harbin , Heilongjiang Province , China State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, Hebei, China Institute of Animal Science; Jiangsu Academy of Agricultural Sciences; Nanjing 210014; China RAND Health, Boston, Massachusetts. Department of Neurology, Qingdao Women and Children's Hospital of Qingdao University Qingdao University Qingdao China Division of Avian Immunosuppressive Diseases, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China Department of Pharmacology (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), College of Pharmacy, Harbin Medical University, Harbin, P. R. China Key Laboratory of Horticultural Plant Biology (MOE) College of Horticulture and Forestry Sciences Huazhong Agricultural University Wuhan China Key Laboratory of Nondestructive Testing, Ministry of Education, Nanchang Hangkong University, Nanchang 330063, People’s Republic of China Department of Cardiology, Third Hospital of Shanxi Medical University, Key Laboratory of Cellular Physiology (Shanxi Medical University), Ministry of Education, China Department of Pathology, Tianjin Medical University, Tianjin, China State Key Laboratory of Crop Biology, Shandong Provincial Key Laboratory for Biology of Vegetable Diseases and Insect Pests, College of plant protection Shandong Agricultural University Tai'an Shandong P.R. China Key Laboratory of Soybean Biology of Chinese Education Ministry, Northeast Agricultural University, 600 Changjiang Road, Harbin 150030, China Discovery Center for Evaluation, Research, and Professional Learning, Miami University, Oxford, Ohio, USA Department of Pulmonary and Critical Care Medicine The First Affiliated Hospital of Soochow University Suzhou Jiangsu China; Suzhou Key Laboratory for Respiratory Diseases Suzhou Jiangsu China Department of Otorhinolaryngology The Third Affiliated Hospital of Sun Yat‐Sen University Guangzhou China Department of Civil, Environmental, and Construction Engineering, Texas Tech University, Lubbock, Texas 79409, United States Department of Nuclear Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China MOE Key Laboratory of Major Diseases in Children, National Key Discipline of Pediatrics (Capital Medical University) National Clinical Research Center for Respiratory Diseases, Beijing Key Laboratory of Pediatric Respiratory Infection Diseases, Beijing Pediatric Research Institute, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, China Collaborative Innovation Center of Modern Biological Breeding Henan Province/Cotton Research Institute Henan Institute of Science and Technology Xinxiang 453003 China School of Life Science and Technology, University of Electronic Science and Technology of China , Chengdu 625014 , China Chinese Education Ministry Key Laboratory of the Three Gorges Reservoir Region’s Eco-Environment, Chongqing University, Chongqing, People’s Republic of China Chemical and Biological Engineering, State University of New York at Buffalo, Buffalo, New York 14260, United States Key Lab of Materials Physics, Anhui Key Lab of Nanomaterials and Nanotechnology, Institute of Solid State Physics, Chinese Academy of Sciences, Hefei 230031, People's Republic of China College of Veterinary Medicine , Northeast Agricultural University , Harbin 150000 , China State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, People’s Republic of China Department of Gastroenterology Key Laboratory of Chinese Health Ministry, Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China Department of Gastroenterology, Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China Institute of Environment and Sustainable Development in Agriculture Chinese Academy of Agricultural Sciences, Ministry of Agriculture Beijing China Department of Respiratory Diseases, Hiser Medical Center of Qingdao, Qingdao, Shandong 266000, P.R. China College of Veterinary Medicine, Northeast Agricultural University, Harbin, Heilongjiang, People’s Republic of China National Engineering Research Center of Electromagnetic Radiation Control Materials, School of Electronic Science and Engineering, University of Electronic Science and Technology of China, Chengdu 611731, China; Key Laboratory of Multi Spectral Absorbing Materials and Structures of Ministry of Education, University of Electronic Science and Technology of China, Chengdu 611731, China School of Biological Engineering, Dalian Polytechnic University, Dalian, China; Key Laboratory of Macromolecular Science of Shaanxi Province, Key Laboratory of Applied Surface and Colloid Chemistry of Ministry of Education, and School of Chemistry & Chemical Engineering, Shaanxi Normal University, 710119 Xi’an, China Heilongjiang Academy of Medical Science Harbin China; Department of Cardiology The First Affiliated Hospital (Key Laboratory of Cardiac Diseases and Heart Failure) Harbin Medical University Harbin China Breast Disease and Reconstruction Center, Breast Cancer Key Lab of Dalian, Second Affiliated Hospital, Dalian Medical University, Dalian, China Intensive Care Unit, The Second Affiliated Hospital of Harbin Medical University, Harbin, PR China Department of Public Health Sciences, University of Rochester, Rochester, New York Laboratory of Cardiovascular Science, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, Maryland Department of Dermatology, State Key Laboratory of Biotherapy and Cancer Center, National Clinical Research Center for Geriatrics, West China Hospital and West China School of Pharmacy, Sichuan University, Chengdu 610041, P. R. China Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520; Department of Chemistry, Graduate School of Science; Kyoto University; Kyoto 606-8502; Japan Department of Chemistry, The Scripps Research Institute, Jupiter, FL 33458; Department of Computer Science McGill University Montreal Quebec Canada; Quantitative Life Science McGill University Montreal Quebec Canada Department of Medicinal Chemistry, Immunophage Biotech Co., Ltd, No. 10 Lv Zhou Huan Road, Shanghai 201112, P. R. China Beijing Anzhen Hospital Affiliated to Capital Medical University Beijing, China. Division of Pulmonary and Critical Care Medicine, Department of Medicine, School of Medicine, University of Maryland20 Penn Street, HSF-2, Room #S112, Baltimore 21201, MD, USA. Department of Obstetrics, Beijing Obstetrics and Gynecology Hospital, Beijing Maternal and Child Health Care Hospital, Capital Medical University, Beijing, China Nebraska Center for Virology, School of Biological Sciences, University of Nebraska-Lincoln , Lincoln, Nebraska, USA; College of Life Sciences, Nankai University , Tianjin, China Department of Cardiology, First Affiliated Hospital, Harbin Medical University Heilongjiang China Ministry of Education Key Laboratory of Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China College of Marine Life Sciences, Ocean University of China, Qingdao, China; Department of Chemistry and Biochemistry, University of Maryland, College Park, Maryland 20742 Key Lab of Materials Physics, Anhui Key lab of Nanomaterials and Nanotechnology, Institute of Solid State Physics, Chinese Academy of Sciences, Hefei 230031, Anhui, P. R China Jiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Sciences, Nanjing Normal University Nanjing China College of Marine Life Sciences, Ocean University of China, Qingdao, PR China; Department of Vaccine Research, Changchun Zhuoyi Biological Co., Ltd., Changchun, China. Department of Chemistry and Biochemistry North Dakota State University Fargo North Dakota 58108‐6050 School of Materials Science and Engineering and Tianjin Key Laboratory of Composite and Functional Materials, Tianjin University, Tianjin 300350, P. R. China Department of Dermatology, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital and West China School of Pharmacy, Sichuan University, Chengdu 610041, China The Animal Experimental Centre, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China BGI Genomics, BGI-Shenzhen, Shenzhen, China; Zhejiang Tiantong Forest Ecosystem National Observation and Research Station School of Ecological and Environmental Sciences East China Normal University Shanghai China College of Life Sciences, Jilin Agricultural University, 2888, Xincheng Street, Changchun City, Jilin Province 130117, China Shanghai Key Laboratory of Molecular Imaging, Shanghai University of Medicine and Health Sciences Shanghai 201318, China. National Engineering Research Center of Electromagnetic Radiation Control Materials and State Key Laboratory of Electronic Thin Films and Integrated Devices, School of Microelectronics and Solid State Electronics, University of Electronic Science and Technology of China, Chengdu 610054, China Department of Rehabilitation, West China Hospital of Sichuan University, Chengdu, China Sydney Pharmacy School, Faculty of Medicine and Health NSW, The University of Sydney , 2006 , Australia School of Biotechnology, Southern Medical University, Guangzhou, China Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, China; NHC Key Laboratory of Myopia, Fudan University, Shanghai, China; Shanghai Key Laboratory of Visual Impairment and Restoration, Shanghai, China Shanxi Institute for Endemic Diseases Control, Xi'an 710003, China. iDAPT, Toronto Rehabilitation Institute – University Health Network, Toronto, Canada State Key Laboratory of Tree Genetics and Breeding, College of Biological Sciences and Technology Beijing Forestry University Beijing China; National Engineering Research Center of Tree Breeding and Ecological Restoration, College of Biological Sciences and Technology Beijing Forestry University Beijing China; The Tree and Ornamental Plant Breeding and Biotechnology Laboratory of National Forestry and Grassland Administration Beijing Forestry University Beijing China Department of Medicine University of Maryland School of Medicine Baltimore MD USA Department of Instrument Management & Analysis, Beijing Institute for Drug Control, Beijing, China Heilongjiang Key Laboratory for Laboratory Animals and Comparative Medicine , College of Veterinary Medicine , Harbin 150030 , China Institute of Biotechnology and Food Science, Hebei Academy of Agricultural and Forestry Sciences, Shijiazhuang 050050, China; College of Life Sciences and Food Engineering, Hebei University of Engineering, Handan 056000, China Department of Chemistry, Graduate School of Science, Kyoto University, Sakyo, Kyoto 606-8502, Japan Department of Chemistry and Biochemistry, North Dakota State University, Fargo, ND, USA College of Resource and Environment, Northeast Agricultural University, Harbin 150030, China. liyue19860715@126.com Key Laboratory of Materials Physics, Anhui Key Laboratory of Nanomaterials and Nanotechnology, Institute of Solid State Physics, Chinese Academy of Sciences, Hefei 230031, Anhui, P.R. China Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, China Department of Endocrinology, Shanghai Fifth People’s Hospital, Fudan University, Shanghai, China Department of Cardiology, the First Affiliated Hospital, Harbin Medical University, Harbin 150001, Heilongjiang Province, P. R. China; Key Laboratory of Cardiac Diseases and Heart Failure, Harbin Medical University, Harbin, 150001, Heilongjiang Province, P. R. China; Institute of Metabolic Disease, Heilongjiang Academy of Medical Science, Harbin, 150001, Heilongjiang Province, P. R. China The Department of Chemistry, The Scripps Research Institute, Jupiter, Florida 33458, United States Department of Gastroenterology Sir Run Run Shaw Hospital, Zhejiang University Medical School Hangzhou, Zhejiang Province China; Institute of Gastroenterology, Zhejiang University Hangzhou, Zhejiang Province China Division of Medical Physics, CancerCare Manitoba, McDermot Avenue, Winnipeg, Manitoba, Canada Institute of Environment and Sustainable Development in Agriculture Chinese Academy of Agricultural Sciences Beijing China; Key Laboratory for Agro‐Environment Ministry of Agriculture Beijing China Key Lab of Materials Physics; Anhui Key Lab of Nanomaterials and Nanotechnology; Institute of Solid State Physics; Chinese Academy of Sciences; Hefei Department of Nephrology, The First Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China College of Biological Sciences and Technology, Beijing Forestry University , Beijing 100083 , China; Key Laboratory of Genetics and Breeding in Forest Trees and Ornamental Plants, Ministry of Education, Beijing Forestry University , Beijing 100083 , China; National Engineering Research Center of Tree Breeding and Ecological restoration, Beijing Forestry University , Beijing 100083 , China Institute of Animal Science, Jiangsu Academy of Agricultural Sciences, Nanjing 210014, China Department of Public Health Services University of Rochester School of Medicine Rochester NY Key Laboratory of Flexible Electronics (KLOFE), Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing Tech University, Nanjing 211816, PR China School of Energy and Power Engineering, Shandong University, Jinan 250061, China Wuhan National Laboratory for Optoelectronics and School of Optical and Electronic Information Huazhong University of Science and Technology Wuhan 430074 China Department of Polymer Materials, School of Materials Science and Engineering, Beijing Institute of Technology, 5 South Zhongguancun Street, Haidian District, Beijing, 100081, China Key Laboratory of Materials Physics, Anhui Key Laboratory of Nanomaterials and Nanotechnology, Institute of Solid State Physics, Chinese Academy of Sciences (CAS), Hefei 230031, Anhui, China,; Nanosystem Research Institute (NRI), National Institute of Advanced Industrial Science and Technology (AIST), Central 5, 1-1-1 Higashi, Tsukuba, Ibaraki 305-8565, Japan Key Laboratory of Microsystems and Microstructures Manufacturing (Ministry of Education), School of Medicine and Health, Harbin Institute of Technology, No. 92 XiDaZhi Street, Harbin, 150001, China Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology Nanfang Hospital Southern Medical University Guangzhou Guangdong Province China Laboratory of Clinical Pharmacokinetics, Institute of Clinical Pharmacology Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine Shanghai China College of Food Science, National R&D Professional Center For Berry Processing, National Engineering and Technology of Research Center For Small berry, Key Laboratory of Healthy Food Nutrition and Innovative Manufacturing, Liaoning Province, Shenyang Agricultural University, Shenyang, Liaoning 110866, China Department of Vascular Surgery, General Hospital of People’s Liberation Army, Beijing, China College of Management and Economics, Tianjin University, Tianjin, China National Key Laboratory for Germplasm Innovation and Utilization of Horticultural Crops, College of Horticulture and Forestry, Huazhong Agricultural University, Wuhan 430070, China; Hubei Hongshan Laboratory, Wuhan 430070, China; Hubei Engineering Technology Research Center for Forestry Information, College of Horticulture and Forestry, Huazhong Agricultural University, Wuhan 430070, China Cardiovascular Department, the First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, P.R. China Nanotechnology Research Institute (NRI), National Institute of Advanced Industrial Science and Technology (AIST), Central 5, 1-1-1 Higashi, Tsukuba, Ibaraki 305-8565, Japan, and Key Laboratory of Materials Physics, Institute of Solid State Physics, Chinese Academy of Sciences, Hefei 230031, Anhui, People's Republic of China Division of Pulmonary and Critical Care, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland State Key Laboratory of Crop Stress Biology for Arid Areas, College of Plant Protection Northwest A&F University Yangling 712100 Shaanxi China; Key Laboratory of Plant Protection Resources and Pest Management, Ministry of Education College of Plant Protection, Northwest A&F University Yangling 712100 Shaanxi China Key Lab of Materials Physics; Anhui Key Lab of Nanomaterials and Nanotechnology; Institute of Solid State Physics; Chinese Academy of Sciences; Hefei 230031 Assistant Professor, Department of Medicine, University of Iowa, Iowa City, Iowa. Basic Medical College, Chongqing Medical University, Chongqing 400016, P.R. China Peking Union Medical Hospital Chinese Academy of Medical Science & Peking Union Medical College Beijing China College of Chemistry and Environment, South China Normal University, Guangzhou 510006, People’s Republic of China Department of New Energy Science & Engineering, College of Materials & Metallurgy, Guizhou University, Huaxi District, Guiyang 550025, P.R. China Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing 100084, China Discovery Center for Evaluation, Research, and Professional Learning, Miami University , Oxford, Ohio, USA Department of Public Health Sciences, University of Rochester School of Medicine, Rochester, NY Qiushi Academy for Advanced Studies, Zhejiang University, Hangzhou, China; Department of Biomedical Engineering, Zhejiang University, Hangzhou, China; Key Laboratory of Biomedical Engineering of Ministry of Education, Zhejiang Provincial Key Laboratory of Cardio-Cerebral Vascular Detection Technology and Medicinal Effectiveness Appraisal, Hangzhou, China Department of Ophthalmology, The Second Xiangya Hospital, Central South University, Changsha 410011, Hunan, The People’s Republic of China; Hunan Clinical Research Center of Ophthalmic Disease, Changsha 410011, Hunan, The People’s Republic of China Department of Epidemiology and Biostatistics, Ministry of Education Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China Institute of Metabolic Disease Research and Drug Development, China Medical University, Shenyang 110122, Liaoning, China First Affiliated Hospital of Harbin Medical University, Harbin, China Department of Hematology, Xianyang Central Hospital, Xianyang, China Sun Yat‐sen University Cancer Center; State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Guangzhou China Department of Cardio-pulmonary Functions, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and therapy, Tianjin, China University at Albany, State University of New York, Albany, NY, USA Foshan University Jiangwan 1st Road 18 528000 Foshan P. R. China Department of Neurology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Department of Integrative Biology and Pharmacology, University of Texas Health Science Center at Houston, Houston, TX, USA Collaborative Innovation Center of Recovery and Reconstruction of Degraded Ecosystem in Wanjiang Basin Co‐founded by Anhui Province and Ministry of Education School of Ecology and Environment Anhui Normal University Wuhu China Department of Intensive Care Unit, PLA General Hospital of Southern Theatre Command, Key Laboratory of Tropical Zone Trauma Care and Tissue Repair of PLA, Guangzhou, People’s Republic of China From the Department of Public Health Sciences, Division of Health Policy and Outcomes Research (Y.K., L.G.G., Y.L.), Department of Anesthesiology (L.G.G.), and Department of Neurology (R.G.H.), University of Rochester Medical Center, NY. Department of Anesthesiology, Peking University Third Hospital, Beijing 100191, China School of Medicine, Tsinghua University, Beijing 100084, P.R. China Department of Lung Cancer Tianjin Lung Cancer Center, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer Tianjin China Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia 30322 McArdle Laboratory for Cancer Research, University of Wisconsin, Madison, Wisconsin 53706 Guangwai Community Health Service Center of Xicheng District Beijing China Division of Immunology, Pediatric Translational Medicine Institute, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China; Department of Rheumatology and Immunology, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China. Department of Pharmacy, Zhangqiu People's Hospital, Zhangqiu, Shandong 250200, China From the Department of Cardiovascular Surgery, Xijing Hospital, The Fourth Military Medical University, Xi’an, China (Y.Y., W.D., Z.J., S.Y., D.Y.); Team 10, School of Stomatology, The Fourth Military Medical University, Xi’an, China (Y.L.); and Department of Prosthodontics, School of Stomatology, The Fourth Military Medical University, Xi’an, China (J.Y.). Department of Public Health Sciences, Division of Health Policy and Outcomes Research, University of Rochester Medical Center, Rochester, NY Center of Liver Diseases, Beijing Ditan Hospital of Capital Medical University, Beijing, China College of Chemistry; Chemical Engineering and Materials Science; Collaborative Innovation Centre of Functionalized Probes for Chemical Imaging in Universities of Shandong; Key Laboratory of Molecular and Nano Probes; Ministry of Education Department of Ophthalmology, Henry Ford Health System, Detroit, Michigan, United States 2Department of Ophthalmology, Shaanxi Maternity and Child Healthcare Hospital, Xi'an, Shaanxi, People's Republic of China Beijing Advanced Innovation Center for Tree Breeding by Molecular Design, College of Biological Sciences and Technology, Beijing Forestry University, No. 35 Qinghua East Road, Haidian District, Beijing 100083, China; National Engineering Laboratory for Tree Breeding, Beijing Forestry University, No. 35 Qinghua East Road, Haidian District, Beijing 100083, China Division of Health Policy and Outcomes Research, Department of Public Health Sciences University of Rochester Medical Center Rochester New York USA Department of Hematology and Oncology, Shenzhen Children's Hospital, Shenzhen, China. Academicians Workstation of Jilin Province Changchun University of Chinese Medicine Changchun China Department of Immunology Peking University Health Science Center Beijing China McGill IR Group, Department of Food Science and Agricultural Chemistry Macdonald Campus of McGill University Sainte‐Anne‐de‐Bellevue Quebec H9X 3V9 Canada Department of Ophthalmology, Henry Ford Hospital, Detroit, MI, USA. College of Chemistry; Zhengzhou University; Green Catalysis Center; and College of Chemistry; Zhengzhou University Zhengzhou Department of Traditional Chinese Medicine, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China Department of Epidemiology and Biostatistics , Ministry of Education Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, , Wuhan, China; Huazhong University of Science and Technology , Ministry of Education Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, , Wuhan, China 1Department of Clinical Laboratory, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, China Waisman Center, University of Wisconsin-Madison, Madison, WI 53705, USA Department of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medicine Sciences & Peking Union Medical College, Beijing 100730,China. Professor, Department of Public Health Sciences, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA State Key Laboratory of Protein and Plant Gene Research, School of Life Sciences, Peking University, Beijing 100871, China. Department of Medical Oncology The Fourth Affiliated Hospital of China Medical University Shenyang China Department of Neurology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China Department of Obstetrics and Gynecology, Shanghai Tenth People’s Hospital School of Medicine, Tongji University, 301 Middle Yanchang Road, Shanghai 200072, P.R. China School of Mathematics and Statistics, University of Science and Technology Beijing, Beijing 100083, China Jiangsu Key Laboratory for Molecular and Medical Biotechnology College of Life Sciences, Nanjing Normal University Nanjing China Department of Gastroenterology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences , Beijing , China Department of Community and Preventive Medicine Division of Health Policy and Outcomes Research University of Rochester Medical Center Rochester NY Key Laboratory of Materials Physics, Anhui Key Laboratory of Nanomaterials and Nanotechnology; Institute of Solid State Physics; Chinese Academy of Sciences; Hefei 230031 Anhui China; Department of Materials Science and Engineering; University of Science and Technology of China; Hefei 230026 China Department of Cardiology, The Second Hospital of Hebei Medical University and The Institute of Cardiocerebrovascular Disease of Hebei Province, Shijiazhuang 050000, China Hebei Key Laboratory of Molecular Cell Biology, College of Biological Sciences, Hebei Normal University, Shijiazhuang, Hebei 050016, China (Y.L., X.X.) Department of Minimal Invasive Neurosurgery of First Affiliated Hospital of Kunming Medical University, Kunming 650032, China. State Key Laboratory of Reliability and Intelligence of Electrical Equipment, Hebei University of Technology, Tianjin, China Department of Nutrition and Food Hygiene, School of Public Health and Management, Chongqing Medical University, Chongqing, China College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, China Laboratory of Cardiovascular Science, Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, MD. Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangdong Engineering Research Center of Oral Restoration and Reconstruction, Affiliated Stomatology Hospital of Guangzhou Medical University, Guangzhou 510182, China School of Electromechanical and Automotive Engineering, Yantai University 1 , Yantai 264005, China The Russell H. Morgan Department of Radiology and Radiological Science The Johns Hopkins University School of Medicine Baltimore Maryland USA; Department of Biomedical Engineering The Johns Hopkins University School of Medicine Baltimore Maryland USA MOE Engineering Research Center of Forestry Biomass Materials and Bioenergy; Beijing Forestry University; Haidian; China School of Public health Qingdao University Qingdao 266071 China Pharmaceutical Institute, Nanjing University of Chinese Medicine, Nanjing, P.R. China Materials Science Division, Argonne National Laboratory , Lemont, IL , United States NHC Key Laboratory of Biotechnology Antibiotics and CAMS Key Laboratory of Synthetic Biology for Drug Innovation, & Institute of Medicinal Biotechnology, Chinese Academy of Medical Science & Peking Union Medical College, Beijing100050, China Gynecology of Traditional Chinese Medicine, Clinical College of Traditional Chinese Medicine, Anhui University of Chinese Medicine, Hefei, China Department of Nephrology, The Affiliated Hongqi Hospital of Mudanjiang Medical University, Mudanjiang, China. Department of Gynecology Weihai Municipal Hospital , Shandong , 264200 , China Division of Health Policy and Outcomes Research, Department of Public Health Sciences, University of Rochester Medical Center, Rochester, New York Department of Ophthalmology and Visual Science, Shanghai Medical College, Eye, Ear, Nose and Throat Hospital, Fudan University, Shanghai, China;; Key Laboratory of Myopia of State Health Ministry and Key Laboratory of Visual Impairment and Restoration of Shanghai, Eye, Ear, Nose and Throat Hospital, Fudan University, Shanghai, China. State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Sun Yat‐sen University Cancer Center Guangzhou China College of Chemistry, Chemical Engineering and Materials Science, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Shandong Normal University, Jinan 250014, P. R. China School of Chemistry and Chemical Engineering, Liaoning Normal University, Dalian 116029, China Department of Biomedical Engineering, Tsinghua University, Beijing 100084, China. State Key Laboratory of Electrical Insulation and Power Equipment, Xi’an Jiaotong University , Xi’an 710049, China Beijing National Laboratory for Molecular Sciences, Key Laboratory of Polymer Chemistry and Physics of Ministry of Education, College of Chemistry and Molecular Engineering Peking University Beijing China School of Emergency Management, Jiangsu University, Zhenjiang 212013, China; School of the Environment and Safety Engineering, Jiangsu University, Zhenjiang 212013, China; Jiangsu Province Engineering Research Center of Green Technology and Contigency Management for Emerging Polluants, Jiangsu University, Zhenjiang 212013, China Key Laboratory of Human Microbiome and Chronic Diseases, Sun Yat-Sen University, Ministry of Education, Guangzhou, China; Guangdong Institute of Gastroenterology, the Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China; Biomedical Innovation Centre, the Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China; The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China Key Laboratory of Plant Protection Resources & Pest Management of the Ministry of Education, College of Plant Protection, Northwest A&F University, Yangling, Shaanxi 712100, China School of Ecology and Nature Conservation, Beijing Forestry University, Beijing 100083, China Department of Chemistry, Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology, Tsinghua University, Beijing 100084, China Division of Pulmonary and Critical Care Medicine, Department of Medicine, School of Medicine, University of Maryland 20 Penn Street, HSF-2, Room #S112, Baltimore 21201, MD, USA. Key Lab of Materials Physics, Anhui Key Lab of Nanomaterials and Nanotechnology, Institute of Solid State Physics, Chinese Academy of Sciences, Hefei 230031, Anhui, PR China Department of Microbiology and Immunology, University of Western Ontario, London, Ontario, Canada Department of Anesthesiology Enshi Central Hospital Enshi China College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, People’s Republic of China State Key Laboratory of Microbial Technology, Marine Biotechnology Research Center, Institute of Marine Science and Technology, Shandong University, Jinan, China School of Chinese Medicine, University of Hong Kong, Hong Kong, China. Key Laboratory of Cluster Science of the Ministry of Education, School of Chemistry and Chemical Engineering, Liangxiang Campus, Beijing Institute of Technology, Beijing 102488, People’s Republic of China West China School of Medicine, Sichuan University, Chengdu 610041, China. Department of Anesthesiology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education) Department of Chemistry Tsinghua University Beijing 100084 P. R. China Beijing Centre For Physical & Chemical Analysis, Beijing 100094, China. Department of Ophthalmology and Visual Science, Eye Institute, Eye and ENT Hospital, Shanghai Medical College of Fudan University, NHC Key Laboratory of Myopia (Fudan University), Shanghai Key Laboratory of Visual Impairment and Restoration, Shanghai, China College of Water Conservancy and Civil Engineering, Inner Mongolia Agricultural University, Hohhot 010010, China School of Material Science and Engineering, Xi’an University of Architecture and Technology, Xi’an 710054, Shaanxi Province, P. R. China School of Biological Science and Technology, University of Jinan, Jinan 250022, China Department of Immunization Program, Hongkou District Centers for Disease Control and Prevention, Shanghai 200082, China Department of Chemistry; Analysis Center; Tsinghua University; Beijing 100084; China School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, P. R. China;; Shenyang Key Laboratory of Functional Drug Carrier Materials, Shenyang Pharmaceutical University, Shenyang, P. R. China; Department of Stomatology, Zhongnan Hospital of Wuhan University, No. 169, Donghu Road, Wuchang District, Wuhan, 430071, China Molecular Medicine and Cancer Research Center, Chongqing Medical University, Chongqing 400016, China Plant Protection Department and Major Crop Disease Laboratory, College of Agronomy, Sichuan Agricultural University, Chengdu, Sichuan 611130, China Department of Cardiology, Yue Bei People’s Hospital, Shantou University Medical College, Shaoguan, China Beijing Center for Physical and Chemical Analysis, Beijing 100094, China Department of Gastroenterology Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China School of Chemistry and Chemical Engineering, Liaoning Normal University, Dalian, 116029, People's Republic of China Department of Neurology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China From the Department of Pharmacology, the State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education (B.S., R.H., Y.S., X.X., C.C., H.-B.L., N.L., C.-B.L., W.-T.G., J.-X.Z., B.-F.Y., D.-L.D.), and the Cardiovascular Department (Y.L.), Harbin Medical University, Harbin, P.R. China. Key Laboratory of Microelectronic Devices & Integrated Technology Institute of Microelectronics Chinese Academy of Sciences Beijing 100029 China; University of Chinese Academy of Sciences Beijing 100049 China Department of Geriatrics The First Affiliated Hospital of Nanjing Medical University Nanjing China Department of Cardiology, the First Affiliated Hospital, Harbin Medical University, Harbin, China; Institute of Metabolic Disease, Heilongjiang Academy of Medical Science, Harbin, China The Clinical Laboratory Center, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China. School of Materials Science and Engineering, College of Chemistry and Chemical Engineering, China University of Petroleum (East China), Qingdao, Shandong 266580, China Department of Epidemiology and Biostatistics, Ministry of Education Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College Huazhong University of Science and Technology Wuhan China Department of Public Health Sciences University of Rochester Rochester NY USA Department of Internal Medicine, Division of General Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA, USA; CADRE, Iowa City Veterans Administration Medical Center, Iowa City, IA, USA Department of Neurology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China (mainland) 1Department of Epidemiology and Biostatistics, Key Laboratory for Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Sciences and Technology, Wuhan, China. Department of Hematology the First Affiliated Hospital of Nanjing Medical University Jiangsu Province Hospital Nanjing China; Key Laboratory of Hematology of Nanjing Medical University Nanjing China; Collaborative Innovation Center for Cancer Personalized Medicine Nanjing China Basic Medical College Jiamusi University Jiamusi Heilongjiang China Department of Gastroenterology Sir Run Run Shaw Hospital Zhejiang University Medical School Hangzhou China; Institute of Gastroenterology Zhejiang University (IGZJU) Hangzhou China Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan 48824, and Macromolecular Crystallography Laboratory, National Cancer Institute, P.O. Box B, Frederick, Maryland 21702 Department of Gastroenterology, First Hospital of Shanxi Medical University Taiyuan, Shanxi, P. R. China. Department of Immunology, Shandong University School of Medicine, Jinan, Shandong 250012, P.R. China State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine; Molecular Diagnostics i-Lab, Nano-X Vacuum Interconnected Workstation, Key Laboratory of Multifunction Nanomaterials and Smart Systems, Suzhou Institute of Nano-Tech and Nano-Bionics (SINANO), Chinese Academy of Sciences (CAS), 398 Ruoshui Road, Suzhou 215123, China Department of Cardiology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China. Sydney Pharmacy School, Faculty of Medicine and Health NSW, The University of Sydney , Sydney, NSW , Australia Department of Biomedical Engineering, The Fourth Military Medical University, Xi’an, China Institute of Metabolic Disease Research and Drug Development China Medical University Shenyang Liaoning 110122 China Department of Gynecology, Weihai Municipal Hospital, Binzhou Medical University, Weihai, Shandong 264200, P.R. China the First Affiliated Hospital of Liaoning University of Traditional Chinese Medicine Shenyang 110032, China. Department of Pharmaceutical Engineering, School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, People’s Republic of China Dalian National Laboratory for Clean Energy Dalian Institute of Chemical Physics Chinese Academy of Sciences Dalian 116023 P. R. China State Key Laboratory of Genetic Resources and Evolution Kunming Institute of Zoology Chinese Academy of Sciences Kunming Yunnan 650223 P. R. China; KIZ‐CUHK Joint Laboratory of Bioresources and Molecular Research of Common Diseases Kunming Yunnan 650223 P. R. China; Kunming College of Life Science University of Chinese Academy of Sciences Kunming Yunnan 650223 P. R. China Department of Ophthalmology and Vision Science; Shanghai Eye; Ear; Nose and Throat Hospital; Fudan University Beijing Center for Physical and Chemical Analysis, 100089, Beijing, China Macromolecular Crystallography Laboratory, National Cancer Institute, Frederick, Maryland 21702, and Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan 48824 The Clinical Laboratory Center of the Second Affiliated Hospital of Chongqing Medical University, Chongqing, China. Associate Professor, Department of Public Health Sciences, Division of Health Policy and Outcomes Research, University of Rochester Medical Center, Rochester, New York, USA State Key Laboratory of Protein and Plant Gene Research, School of Life Sciences, Peking University, 100871 Beijing, China; Yue Li is an associate professor of community and preventive medicine at the University of Rochester. Department of Biology and Biochemistry; University of Houston; 4800 Calhoun Rd Houston Texas 77214 for the CCC-ACS Investigators Department of Neurosurgery, West China Hospital Sichuan University No. 37 Guoxue Lane Chengdu Sichuan China College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, China Department of Cardiology The First Affiliated Hospital of Harbin Medical University Harbin Medical University Harbin Heilongjiang 150001 China Research Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, P.R. China School of Computer, University of South China, Hengyang, Hunan, China Department of Dermatology, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, and West China School of Pharmacy, Sichuan University, Chengdu 610041, P.R. China Department of Biotechnology, College of Chemical Engineering and Biotechnology, Hebei Polytechnic University, Tangshan Hebei 063009, PR China. Department of Immunology, Peking University Health Science Center; School of Food Science and Technology Jiangnan University Wuxi Jiangsu China Department of Respiratory Medicine, Qingdao Hiser Medical Center, Qingdao, 266033 Shandong Province, China Heilongjiang Key Laboratory for Laboratory Animals and Comparative Medicine, College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China Department of Gastroenterology and Endoscopy, First Affiliated Hospital of China Medical University, Shenyang, People’s Republic of China Department of Molecular Biophysics & Biochemistry, Yale University; New Haven CT USA AnatomyWorks LLC Baltimore Maryland Department of Nuclear and Quantum Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 305-701, Korea, Department of Electrical Engineering and Computer Science, KAIST, Daejeon 305-701, Korea, and Key Lab of Materials Physics, Institute of Solid State Physics, Chinese Academy of Sciences, Hefei 230031, Anhui, P. R. China Public Health Sciences, University of Rochester School of Medicine, Rochester, New York Clinical College of Ophthalmology Tianjin Medical University Tianjin China; Tianjin Key Laboratory of Ophthalmology and Visual Science Tianjin Eye Institute Tianjin Eye Hospital Tianjin China College of Plant Protection, Northwest A & F University, Yangling 712100, China Hebei Key Laboratory of Molecular and Cellular Biology, Key Laboratory of Molecular and Cellular Biology of the Ministry of Education, College of Life Sciences, Hebei Normal University, Hebei Collaboration Innovation Center for Cell Signaling, Shijiazhuang, Hebei 050024, China Department of Endocrinology, Tianjin Third Central Hospital, Tianjin, China Department of Clinical Laboratories, Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, China Waisman Center, University of Wisconsin–Madison, Madison, WI 53705;; Department of Neuroscience, University of Wisconsin–Madison, Madison, WI 53705;; Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China Department of Anesthesiology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China Department of Food Science; University of Massachusetts; Amherst, USA; Key Laboratory of Food Colloids and Biotechnology; Ministry of Education College of Chemistry and Environment; South China Normal University; Guangzhou 510006; People's Republic of China Dresden Integrated Center for Applied Physics and Photonic Materials (IAPP), Technische Universität Dresden, Nöthnitzer Straße 61, Dresden 01187, Germany School of Computer Science and Engineering, South China University of Technology, Guangdong, China Translational Bio-Nanosciences Laboratory Department of Pharmaceutical Sciences The Skaggs School of Pharmacy and Pharmaceutical Sciences University of Colorado Anschutz, Medical Campus Aurora CO 80045 USA; Colorado Center for Nanomedicine and Nanosafety University of Colorado Anschutz Medical Campus Aurora CO 80045 USA Department of Endocrinology, Shanghai Fifth People’s Hospital, Fudan University, Shanghai 200240, China National Engineering Research Center of Electromagnetic Radiation Control Materials, School of Electronic Science and Engineering, University of Electronic Science and Technology of China, Chengdu 611731, China. Beijing Key Laboratory of Bioelectromagnetics Institute of Electrical Engineering Chinese Academy of Sciences Beijing China From the Department of Anesthesiology (L.G.G.) and Department of Public Health Sciences (Y.L.), University of Rochester School of Medicine, Rochester, New York; and RAND Health, RAND, Boston, Massachusetts (L.G.G., A.W.D.). Department of Lung Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin’s Clinical Research Center for Cancer, Tianjin Lung Cancer Center, Tianjin 300060, China Institute of Nuclear and New Energy Technology; Tsinghua University; Beijing 100084; China Department of Pharmaceutical Engineering, School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, P. R. China Discovery Center for Evaluation, Research, and Professional Learning, Miami University, Oxford, OH, USA College of Life Sciences/Key Laboratory of Agricultural Environmental Microbiology, Ministry of Agriculture and Rural Affairs, Nanjing Agricultural University, Nanjing, Jiangsu 210095, China. Institute of Pharmacology and Toxicology Key Laboratory of Medical Neurobiology of the Ministry of Health of China College of Pharmaceutical Sciences Zhejiang University Hangzhou China Department of Hematology and Oncology Shenzhen Children's Hospital Shenzhen China State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, Harbin 150090, China. International Joint Laboratory of Catalytic Chemistry, State Key Laboratory of Advanced Special Steel, Department of Chemistry, Research Center of Nano Science and Technology, College of Sciences, Shanghai University, Shanghai 200444, China; Special Glass Key Lab of Hainan Province, School of Materials Science and Engineering, Hainan University, Haikou, Hainan 570228, China State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, China; School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, China Department of Materials Science & Engineering; Northwestern University; Evanston; USA Department of Neurology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China (mainland) Department of Biomedical Engineering The Fourth Military Medical University Xi'an China Department of Neurology, Beijing Chaoyang Hospital Affiliated to Capital Medical University State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China Department of Materials Science and Engineering, Northwestern University, Evanston, Illinois 60208, United States Department of Dermatology Xinhua Hospital Shanghai China; Institute of Dermatology Shanghai Jiaotong University School of Medicine Shanghai China Yunnan Key Laboratory of Metal-Organic Molecular Materials and Device, School of Chemistry and Chemical Engineering, Kunming University, Kunming 650214, China Beijing Key Laboratory of Learning and Cognition, School of Psychology Capital Normal University Beijing China Department of Anesthesiology, Peking University Third Hospital, Beijing, China Department of Chemistry University of Southern California Los Angeles California USA Laboratory of Ultrasound Molecular Imaging, Department of Ultrasound Medicine, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou 510000, China; Liwan Experimental Center, The Liwan Hospital of the Third Affiliated Hospital of Guangzhou Medical University, Guangzhou 510000, China Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520 Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Xi’an Jiaotong University Health Science Center, Xi’an, Shaanxi 710061, China; Key Laboratory of Environment and Genes Related to Diseases (Xi’an Jiaotong University), Ministry of Education, Xi’an, Shaanxi 710061, China Ecological Environment Science & Technology Co. Ltd, China Coal Technology & Engineering Group, Beijing 100013, PR China Institute of Pharmacology & Toxicology, College of Pharmaceutical Sciences, Key Laboratory of Medical Neurobiology of the Ministry of Health of China, Zhejiang University, Hangzhou, China At the time of the study, Yue Li and Dana B. Mukamel were with the Health Policy Research Institute and the Department of Medicine, University of California, Irvine. School of Metallurgy and Environment, Central South University, Changsha, Hunan 410083, China; National Engineering Research Center of Low-carbon Nonferrous Metallurgy, Central South University, Changsha, Hunan 410083, China; Engineering Research Center of the Ministry of Education for Advanced Battery Materials, Central South University, Changsha, Hunan 410083, China Authors' Affiliations: 1Department of Cardiovascular Surgery, Xijing Hospital; Faculty of Pharmacy, The University of Sydney, Sydney, NSW 2006, Australia Key Laboratory of Plant Protection Resources & Pest Management of the Ministry of Education, College of Plant Protection Northwest A&F University Yangling China Key Laboratory of Drug-Targeting and Drug Delivery System of the Ministry of Education and Sichuan Research Center for Drug Precision Industrial Technology West China School of Pharmacy Sichuan University Chengdu 610041 China Department of Anesthesiology, Hulunbeier Municipal People’s Hospital (Hulunbuir Hospital Affiliated to Suzhou University Hulunbuir) , Inner Mongolia , China Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston, Houston, Texas Key Lab of Materials Physics Anhui Key Lab of Nanomaterials and Nanotechnology Institute of Solid State Physics, Chinese Academy of Sciences Hefei 230031 P.R. China Yue Li ( ) is an assistant professor in the Department of Internal Medicine at the University of Iowa, in Iowa City. Department of Public Health Sciences, Division of Health Policy and Outcomes Research, University of Rochester Medical Center, Rochester, New York, USA Public Health Sciences, University of Rochester School of Medicine and Dentistry, Rochester, NY Department of Cardiology, The First Affiliated Hospital of Harbin Medical University, Harbin Medical University , Harbin , Heilongjiang Province , China 1College of Veterinary Medicine, South China Agricultural University, Guangzhou, China Department of Gastroenterology, Peking Union Medical College Hospital Chinese Academy of Medicine Sciences & Peking Union Medical College Beijing China Yue Li, University of Rochester. Beijing Forestry University National Engineering Research Center of Tree Breeding and Ecological Restoration, College of Biological Sciences and Technology, , Beijing 100083, China Department of Chemistry Graduate School of Science Kyoto University Kitashirakawa-Oiwakecho Sakyo-ku Kyoto 606-8502 Japan College of Horticulture and Forestry Huazhong Agricultural University Wuhan China School of International Pharmaceutical Business, China Pharmaceutical University, Nanjing 210009, China. Department of Sports Medicine, Beijing Jishuitan Hospital, Beijing, China Department of Molecular Biophysics & Biochemistry; Yale University; New Haven; CT; 06520; USA State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China Department of Gastroenterology The First Affiliated Hospital of China Medical University Shenyang People's Republic of China Department of Cardiology, The First Affiliated Hospital, Harbin Medical University, Harbin, China;; Key Laboratory of Cardiac Diseases and Heart Failure, Harbin Medical University, Harbin, China; and; Institute of Metabolic Disease, Heilongjiang Academy of Medical Science, Harbin, China. Yue Li ( ) is an associate professor in the Department of Public Health Sciences at the University of Rochester, in New York. Department of Otorhinolaryngology The First Affiliated Hospital of Chinese People's Liberation Army General Hospital Beijing China The Sixth Department of Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, China Department of Nutrition, University of North Carolina, Chapel Hill, North Carolina; Yue Li is an associate professor of public health sciences, University of Rochester School of Medicine. Department of Lung Cancer, Tianjin Medical University, Tianjin 300060, China. College of Life Sciences, Hebei Agricultural University, Baoding 071001, China Beijing International Studies University, Beijing 100000, China Department of Electrical Engineering and State Key Laboratory of Terahertz and Millimeter Waves; City University of Hong Kong; Kowloon; China Department of Biochemistry, Michigan State University, East Lansing, Michigan 48824, and Department of Biochemistry, University of WisconsinMadison, 420 Henry Mall, Madison, Wisconsin 53706 Brandeis University, Waltham, MA Division of Avian Infectious Diseases, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China Business School Sichuan University Chengdu China Department of Public Health Sciences, University of Rochester School of Medicine and Dentistry, New York, USA Department of Psychiatry, University of Rochester Medical Center, Rochester, New York 14642, USA. kenneth_conner@urmc.rochester.edu Beijing National Laboratory for Molecular Sciences, Key Laboratory of Photochemistry, Institute of Chemistry, The Chinese Academy of Sciences, Beijing 100190, China Department of Hematology The First Affiliated Hospital of Jinan University Guangzhou Guangdong China Department of Histology and Embryology Chongqing Medical University Chongqing P. R. China; Laboratory of Stem Cells and Tissue Engineering Chongqing Medical University Chongqing P. R. China College of Pharmacy Harbin University of Commerce Harbin China School of Ecology and Environment, Inner Mongolia University, Huhhot 010021, China College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu, China; Jiangsu Co-Innovation Center for the Prevention and Control of Important Animal Infectious Disease and Zoonoses, Yangzhou, Jiangsu, China; The International Joint Laboratory for Cooperation in Agriculture and Agricultural Product Safety, Ministry of Education, Yangzhou University, Yangzhou, Jiangsu, China; Jiangsu Research Centre of Engineering and Technology for Prevention and Control of Poultry Disease, Yangzhou, Jiangsu, China Yue Li is a professor in the Department of Public Health Sciences, University of Rochester School of Medicine and Dentistry. School of Pharmaceutical Sciences, Health Science Center, Shenzhen University Shenzhen China Department of Chemistry, TKL of Metal- and Molecule-Based Material Chemistry and Synergetic Innovation Center of Chemical Science and Engineering (Tianjin), Nankai University, Tianjin 300071, China Department of Public Health Sciences, University of Rochester School of Medicine, Rochester, New York Key Laboratory of Polyoxometalate Science of the Ministry of Education and Faculty of Chemistry Northeast Normal University Changchun 130024 P. R. China Neck-Shoulder and Lumbocrural Pain Division 1, Sichuan Province Orthopedic Hospital, Chengdu, 610041, China. Ly15872003@163.com. College of Chemistry, Nankai University, No. 94 of Weijin Road, Tianjin 300071, China; Key Laboratory of Advanced Energy Materials Chemistry (Ministry of Education), Nankai University, Tianjin 300071, China Department of Pediatrics The First Affiliated Hospital of Nanjing Medical University Nanjing China Heart Center, The Second Hospital of Hebei Medical University , 215 Heping West Road, Shijiazhuang, Hebei 050000 , China Department of Endocrinology Shunde Hospital, Southern Medical University Foshan Guangdong China Shanghai Institute of Pharmaceutical Industry, Shanghai 200040, China. liyue.cn@126.com Key Lab of Materials Physics Anhui Key Lab of Nanomaterials and Nanotechnology Institute of Solid State Physics HFIPS Chinese Academy of Sciences Hefei 230031 P. R. China State Key Laboratory of Food Nutrition and Safety, College of Food Science and Engineering, Tianjin University of Science and Technology, Tianjin 300457, China Department of Respiratory Diseases, Qingdao Haici Hospital, Qingdao Haici Hospital, Qingdao, China; Department of Pulmonary and Critical Care Medicine, Qingdao Haici Hospital, Qingdao, China Department of Histology and Embryology School of Basic Medical Sciences Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases The Third Affiliated Hospital of Southern Medical University Southern Medical University Guangzhou 510515 P. R. China; Department of Plastic and Aesthetic Surgery Nanfang Hospital of Southern Medical University Guangzhou 510515 P. R. China Department of Epidemiology and Biostatistics, Ministry of Education Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology , 13 Hangkong Road, Wuhan 430030 , China Department of Obstetrics Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital Beijing China Department of Neurology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, P.R. China Key Laboratory of Microsystems and Microstructures Manufacturing, Ministry of Education, Micro/Nanotechnology Research Centre, Harbin Institute of Technology, Yi Kuang Jie 2, Harbin 150080, China Key Lab of Animal Bacteriology; Ministry of Agriculture; Nanjing Agricultural University; Nanjing; China Department of Lung Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, P.R. China Department of Hepatobiliary Surgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine,Sun Yat‐sen University Cancer Center,Guangzhou,China Waisman Center and Department of Neuroscience University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin, USA Department of Nursing, Beijing Tongren Hospital, Capital Medical University, Beijing, China State Key Laboratory of Food Nutrition and Safety, College of Food Science and Engineering, Tianjin University of Science & Technology, Tianjin 300457, China Department of Respiratory, Guangzhou Institute of Pediatrics, Guangzhou Women and Children’s Medical Centre, Guangzhou Medical University, Guangzhou, Guangdong, China Otolaryngology-Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, China. Department of Electrical Engineering and State Key Laboratory of Terahertz and Millimeter Waves, City University of Hong Kong, Hong Kong Special Administrative Region 999077, P. R. China Department of Neurology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology , Wuhan, Hubei, China Department of Radiation Oncology Peking University First Hospital Beijing China State Key Laboratory of Microbial Technology, Marine Biotechnology Research Center Shandong University Qingdao China Department of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China The First-Affiliated Hospital of Harbin Medical University, Harbin 150001, China. Institute of Medicinal Plant Development; Chinese Academy of Medical Science; Peking Union Medical College; Beijing 100193; China Department of Physiology, Basic Medical College, Jiamusi University, Jiamusi, Heilongjiang 154007, P.R. China Institute of Bioorganic & Medicinal Chemistry, School of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, P. R. China Department of Gastroenterology, Peking Union Medical College Hospital Peking Union Medical College & Chinese Academy of Medical Science Beijing China Department of Anesthesia, Tianjin Cancer Hospital, Tianjin Medical University, 300070 Tianjin, China. liyue19575@yahoo.com.cn Key Laboratory of Molecular Microbiology and Biotechnology (Ministry of Education) and Key Laboratory of Microbial Functional Genomics (Tianjin), College of Life Sciences, Nankai University, Tianjin 300071, China Department of Geriatrics, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China Beijing Key Laboratory of Bioelectromagnetism Institute of Electrical Engineering Chinese Academy of Sciences Beijing China Division of Pulmonary and Critical Care Medicine, Department of Medicine, and Novartis Pharma AG Basel Switzerland Aerospace Central Hospital, Beijing, China Department of Endocrinology, Shanghai Fifth People’s Hospital, Fudan University , Shanghai 200240 , China Department of Chemistry, Scripps Research Institute, 130 Scripps Way, Jupiter, FL 33458, USA. Sports Medicine Service, Beijing Jishuitan Hospital, Beijing, China Frontiers Science Center for Flexible Electronics (FSCFE) & Institute of Flexible Electronics (IFE) Northwestern Polytechnical University Xi'an 710072 China; MIIT Key Laboratory of Flexible Electronics (KLoFE) Northwestern Polytechnical University Xi'an 710072 P. R. China School of Public health, Qingdao University, Qingdao, China; Institute of Nutrition & Health, Qingdao University, Qingdao, China Department of Infectious Diseases, Sir Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, People’s Republic of China; Key Laboratory of Microbial Technology and Bioinformatics of Zhejiang Province, Hangzhou, People’s Republic of China; Regional Medical Center for National Institute of Respiratory Diseases, Sir Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, People’s Republic of China Faculty of Medical Laboratory Science, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, 200025 Shanghai, China. 2 CSAIL, Massachusetts Institute of Technology, Cambridge, MA 02139-4307, USA and The First Affiliated Hospital, Medical Imaging Centre, Hengyang Medical School, University of South China, Hengyang, Hunan, China; Institute of Medical Imaging, University of South China, Hengyang, China; Laboratory of Ultrasound Molecular Imaging, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China Department of General Surgery, Yangpu Hospital, School of Medicine, Tongji University, Shanghai, 200090, China College of Chemistry, Chemical Engineering and Materials Science, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Shandong Normal University, Jinan 250014, People’s Republic of China State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Centre for Disease Control and Prevention, Beijing, China Department of Child Health Care The First Affiliated Hospital of Nanjing Medical University Nanjing China Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Colloid, Interface and Chemical Thermodynamics, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China; CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Beijing 100190, China; College of Life Science, Jilin University, Changchun 130012, China MOE Key Laboratory of Spectrochemical Analysis and Instrumentation; State Key Laboratory of Physical Chemistry of Solid Surfaces; College of Chemistry and Chemical Engineering; Xiamen University; Xiamen 361005 Beijing National Laboratory for Molecular Sciences (BNLMS) CAS Key Lab of Colloid, Interface and Chemical Thermodynamics Institute of Chemistry Chinese Academy of Sciences Beijing 100190 China; CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety National Center for Nanoscience and Technology Beijing 100190 China Department of Laboratory; Nanfang Hospital; Southern Medical University; Guangzhou; China Department of Chemistry and Biochemistry, University of Maryland College Park, College Park, Maryland 20740, United States Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China State Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, China 1 Department of Computer Science, 2 The Donnelly Centre, University of Toronto, Toronto, Ontario M5S 3E1, Canada, 3 College of Information Science and Engineering, Hunan University, Changsha, Hunan, 410082, China and 4 Banting and Best Department of Medical Research and Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 3E1, Canada; 1 Department of Computer Science, 2 The Donnelly Centre, University of Toronto, Toronto, Ontario M5S 3E1, Canada, 3 College of Information Science and Engineering, Hunan University, Changsha, Hunan, 410082, China and 4 Banting and Best Department of Medical Research and Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 3E1, Canada Department of Computer Sciences, University of Saskatchewan, Saskatoon, Saskatchewan, Canada Astbury Centre for Structural Molecular Biology, University of Leeds, Woodhouse Lane, LeedsLS2 9JT, UK; School of Chemistry, University of Leeds, Woodhouse Lane, LeedsLS2 9JT, UK College of Veterinary Medicine, Northeast Agricultural University, Harbin, China Beijing Key Laboratory of Bioelectromagnetics, Institute of Electrical Engineering, Chinese Academy of Sciences, Beijing, China Department of Public Health Sciences, Division of Health Policy and Outcomes Research University of Rochester Medical Center 265 Crittenden Blvd., CU 420644 14642 Rochester NY USA National Institute of Advanced Industrial Science and Technology, Central 5, 1-1-1 Higashi, Tsukuba, Ibaraki 305-8565, Japan University of Science and Technology of China Nanjing Medical University, Nanjing, China. Department of Otolaryngology Head and Neck Surgery，Beijing Tongren Hospital，Capital Medical University，Beijing Institute of Otolaryngology，Key Laboratory of Otolaryngology Head and Neck Surgery，Capital Medical University，Ministry of Education，Beijing，100005，China. Spine Disease Research Institute, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, P. R. China; Key Laboratory of Theory and Therapy of Muscles and Bones, Ministry of Education, Shanghai 200032, P. R. China Heilongjiang Key Laboratory for Laboratory Animals and Comparative Medicine, College of Veterinary Medicine Northeast Agricultural University Harbin China School of Life Science and Technology , University of Electronic Science and Technology of China, Chengdu 610054 , China College of Life Sciences, Hebei Normal University, Shijiazhuang, China Department of Immunology, School of Basic Medical Sciences, Shandong University, Jinan, Shandong 250012, P.R. China Department of Biological Sciences University of Notre Dame 46556 Notre Dame IN USA State Key Laboratory of Agricultural Microbiology College of Veterinary Medicine Huazhong Agricultural University Wuhan 430070 China Shenyang Institute of Computing Technology, Chinese Academy of Sciences, Shenyang 110168, China; University of Chinese Academy of Sciences, Beijing 100049, China; Liaoning Key Laboratory of Domestic Industrial Control Platform Technology on Basic Hardware and Software, Shenyang 110168, China Department of Gastroenterology Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College Beijing China College of Environmental and Energy Engineering, Beijing University of Technology, Beijing 100124, China. Key Lab of Polyoxometalate and Reticular Material Chemistry of Education, Northeast Normal University, Changchun 130024, China Department of Radiation Oncology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050035, P.R. China College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China; Animal Husbandry and Veterinary Station, Zhuba Street, Hongze District, Huai’an 223100, China Molecular Biology Institute and Department of Microbiology, Immunology and Molecular Genetics, UCLA, Los Angeles, California 90095-1570 School of Basic Medical Science, Anhui Medical University, Hefei, Anhui, China (mainland) From the School of Medical Sciences, The University of New South Wales Sydney, Australia (B.J.W., K.L.O., Y.S., S.S., L.H., P.J.B., K.-A.R.); Institute of Pathophysiology and Immunology, Medical University of Graz, Austria (Y.S.); and Merck & Co., Inc, Kenilworth, NJ (D.J.). Department of Basic Medicine, Haihe Clinical College of Tianjin Medical University, Tianjin 300350, China State Key Laboratory of Silicon Materials, School of Materials Science and Engineering, Zhejiang University, Hangzhou, People’s Republic of China; Zhejiang-California International NanoSystems Institute, Zhejiang University, Hangzhou, People’s Republic of China Department of Cardiology, The First Affiliated Hospital, Harbin Medical University, Harbin, 150001, Heilongjiang Province, P. R. China; Key Laboratory of Cardiac Diseases and Heart Failure, Harbin Medical University, Harbin, 150001, Heilongjiang Province, P. R. China; Institute of Metabolic Disease, Heilongjiang Academy of Medical Science, Harbin, 150086, Heilongjiang Province, P. R. China Key Laboratory of Cancer Prevention and Therapy of Tianjin, Department of Lung Cancer Surgery, Tianjin Lung Cancer Center, Tianjin Cancer Institute and Hospital Tianjin Medical University 300060 Tianjin China School of Basic Medical Sciences Zhejiang University Hangzhou China Department of Public Health Sciences, University of Rochester School of Medicine, Rochester, NY, USA Partnership for Sensors and Surface Technology, Departments of Chemistry, Food Science and Nutrition, Physics, Chemical Engineering, and Electrical Engineering, University of Rhode Island, Kingston, Rhode Island 02881 Yue Li ( ) is an associate professor in the Department of Public Health Sciences, University of Rochester School of Medicine and Dentistry, in New York. State Key Laboratory of Protein and Plant Gene Research, School of Advanced Agricultural Sciences and School of Life Sciences, Peking University, Beijing 100871, China Clinical Nutrition Department of the First Affiliated Hospital of Xinjiang Medical University , Urumqi 830011, Xinjiang , China College of Veterinary Medicine, South China Agricultural University Sino‐French Institute for Earth System Science College of Urban and Environmental Sciences Peking University Beijing China i-Lab, Key Laboratory of Multifunctional Nanomaterials and Smart Systems, Suzhou Institute of Nano-Tech and Nano-Bionics (SINANO), Chinese Academy of Sciences (CAS), 398 Ruoshui Road, Suzhou 215123, P. R. China; School of Nano-Tech and Nano-Bionics, University of Science and Technology of China, 96, Jinzhai Road, Hefei, Anhui 230026, P. R. China Spine Disease Research Institute, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China Beijing Advanced Innovation Center for Tree Breeding by Molecular Design, National Engineering Laboratory for Tree Breeding, College of Biological Sciences and Technology, Beijing Forestry University, Beijing 100083, PR China Key Lab of Materials Physics; Anhui Key Lab of Nanomaterials and Nanotechnology; Institute of Solid State Physics; Hefei Institutes of Physical Science; Chinese Academy of Sciences Clinical Pharmacy, Shandong Provincial Qianfoshan Hospital, The First Affiliated Hospital of Shandong First Medical University, Jinan, China Department of Cardiology, First Affiliated Hospital of Harbin Medical University, Harbin, China College of Chemistry; Chemical Engineering and Materials Science; Key Laboratory of Molecular and Nano Probes; Engineering Research Center of Pesticide and Medicine Intermediate Clean Production; Ministry of Education Department of Cardio-pulmonary Functions, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China Division of Cardiovascular MedicineDepartment of Internal MedicineUniversity of Iowa Carver College of Medicine; Iowa CityIowaUSA University of Science and Technology of China; Chinese Academy of Sciences The University of Sydney, Sydney Pharmacy School, Faculty of Medicine and Health NSW , 2006 , Australia State Key Laboratory of Experimental Hematology National Clinical Research Center for Blood Diseases Institute of Hematology & Blood Diseases Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Tianjin China Yue Li ( ) is an associate professor in the Department of Public Health Sciences at the University of Rochester Medical Center, in New York. MOE Key Laboratory of Wooden Material Science and Application; Beijing Key Laboratory of Lignocellulosic Chemistry; MOE Engineering Research Center of Forestry Biomass Materials and Bioenergy; Beijing Forestry University; Beijing Department of Haematology the First Affiliated Hospital of Nanjing Medical University Jiangsu Province Hospital Nanjing 210029 China State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China Department of Neurology Beijing Chao‐yang Hospital Capital Medical University Beijing China University of Rochester Medical Center College of Animal Science and Veterinary Medicine, Jilin University, Changchun, PR China Zhejiang Laboratory, Research Institute of Intelligent Computing, Hangzhou 311121, China Department of Breast Disease and Reconstruction Center, Breast Cancer Key Lab of Dalian, the Second Hospital of Dalian Medical University, Dalian, China Key Laboratory of Advanced Structural Materials of Ministry of Education, Changchun University of Technology, Changchun 220103, China School of Chemistry and Material Science Shanxi Normal University Linfen Shanxi P. R. China Yue Li is with the Division of General Internal Medicine, Carver College of Medicine, and Jun Yin is with the Department of Biostatistics, College of Public Health, University of Iowa, Iowa City. Yue Li is also with the Veterans Affairs Medical Center, Iowa City. Laurent G. Glance is with the Department of Anesthesiology, University of Rochester School of Medicine, Rochester, NY. Dana B. Mukamel is with the Department of Medicine and Health Policy Research Institute, University of California, Irvine. Department of Gastroenterology, Peking Union Medical College Hospital Chinese Academy of Medical Sciences Beijing China Key Laboratory of Macromolecular Science of Shaanxi Province; Key Laboratory of the Ministry of Education for Medicinal Resources and Natural Pharmaceutical Chemistry; School of Chemistry & Chemical Engineering; Shaanxi Normal University; 710119 Xi’an Department of Endocrinology, Shanghai Fifth People’s Hospital, Shanghai Medical School, Fudan University, Shanghai 200032, China WuXi NextCODE, Shanghai, People’s Republic of China School of Agriculture and Biology Shanghai Jiao Tong University Shanghai 200240 China Key Laboratory of Physics and Technology for Advanced Batteries Ministry of Education College of Physics Jilin University Changchun 130012 P.R. China; College of Life Sciences Jilin University Changchun 130012 P.R. China Key Laboratory of Theoretical Chemistry of Environment, Ministry of Education, School of Chemistry and Environment, South China Normal University, Guangzhou 510006, People’s Republic of China Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA AnatomyWorks, LLC Baltimore MD USA Shanghai Institute of Pharmaceutical Industry; Shanghai P.R. China Department of Integrated Traditional and Western Medicine, The Third Affiliated Hospital of SunYat-sen University, Guangzhou, P.R. China Xi'an Mental Health Center, Xi'an 710061, China. 864465447@qq.com Department of Otolaryngology–Head and Neck Surgery, Xuanwu Hospital, Capital Medical University, Beijing, China University of Rochester Department of Chemistry, , Rochester, New York 14627 College of Lifesciences, Nankai University, Tianjin, China. Department of Dermatology The Third Affiliated Hospital of Soochow University Changzhou Jiangsu China Department of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China Department of Neurosurgery, The First Affiliated Hospital of Harbin Medical University Harbin 150001, Heilongjiang, P. R. China. Department of Dermatology Huashan Hospital Fudan University Shanghai China School of Public Health of Jilin University; Changchun; P. R. China School of Polymer Science and Engineering Qingdao University of Science and Technology Qingdao 266071 P. R. China State Key Laboratory for Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun 130012, China Division of Pulmonary and Critical Care Medicine, Department of Medicine, School of Medicine, University of Maryland 20 Penn Street, HSF-2, Room #S112, Baltimore, MD 21201, USA. Key Laboratory of Soybean Biology of Ministry of Education China, Key Laboratory of Soybean Biology and Breeding (Genetics) of Ministry of Agriculture and Rural Affairs Northeast Agricultural University Harbin China Key Laboratory of Vegetation Restoration and Management of Degraded Ecosystems & CAS Engineering Laboratory for Vegetation Ecosystem Restoration on Islands and Coastal Zones South China Botanical Garden Chinese Academy of Sciences Guangzhou China; Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou) Guangzhou China Laboratory of Translational Medicine, Jiangsu Province Academy of Traditional Chinese Medicine, No. 100, Shizi Street, Hongshan Road, Nanjing 210028, Jiangsu Province, P.R. China. Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA 52242; Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology Southern Medical University Guangzhou China Department of Hematology and Oncology, Shenzhen Children’s Hospital, Shenzhen, China Guiyang Maternal and Child Health-Care Hospital, Guiyang 550000, P.R. China Dell Pediatric Research Institute, The University of Texas, Austin, TX 78712; Key Laboratory of Polyoxometalate and Reticular Material Chemistry of Ministry of Education, Faculty of Chemistry, Northeast Normal University, Changchun 130024, China Department of Public Health Sciences, Division of Health Policy and Outcomes Research Department of Ophthalmology, Beijing Key Laboratory of Restoration of Damaged Ocular Nerve, Peking University Third Hospital, Beijing, Haidian, China School of Materials Science and Engineering, China University of Petroleum (East China), Qingdao, Shandong 266580, China Beijing National Laboratory for Molecular Sciences (BNLMS) CAS Key Lab of Colloid Interface and Chemical Thermodynamics Institute of Chemistry Chinese Academy of Sciences Beijing 100190 China; University of Chinese Academic of Sciences Beijing 100049 China Key Laboratory for Organic Electronics and Information Displays Institute of Advanced Materials (IAM) Center for Molecular Systems and Organic Devices (CMSOD) Nanjing University of Posts and Telecommunications Wenyuan Road 9 Nanjing 210023 China Department of Gastroenterology, Peking Union Medical College Hospital , Beijing , China Department of Obstetrics and Gynecology, Beijing Friendship Hospital, Capital Medical University, Beijing, China Key Laboratory of Molecular and Cell Biology, College of Life Sciences Hebei Normal University Shijiazhuang China Department of Statistics and Data Science, Carnegie Mellon University, Pittsburgh, PA 15213; Department of Computer Science, University of Toronto, Toronto, Ontario, M5S 2E4, Canada 2 The Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada, 3 Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A4, Canada and 4 Banting and Best Department of Medical Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada; Department of Computer Science, University of Toronto, Toronto, Ontario, M5S 2E4, Canada 2 The Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada, 3 Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A4, Canada and 4 Banting and Best Department of Medical Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada Hangzhou Huatai Testing Technology Co. Ltd.,, Hangzhou 310000, Zhejiang, China McArdle Laboratory for Cancer Research, University of Wisconsin, Madison, Wisconsin 53706. Basic Medical College, Jiamusi University, Jiamusi 154002, Heilongjiang, China; Key Laboratory of Microecology-immune Regulatory Network and Related Diseases, Jiamusi 154002, Heilongjiang, China State Key Laboratory of Crop Gene Exploration and Utilization in Southwest China, Sichuan Agricultural University, Chengdu, Sichuan, 611130, China.; Triticeae Research Institute, Sichuan Agricultural University, Chengdu, Sichuan, 611130, China. i‐Lab Suzhou Institute of Nano‐Tech and Nano‐Bionics (SINANO) Chinese Academy of Sciences (CAS) 398 Ruoshui Road Suzhou 215123 P. R. China Department of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing , China Institute of Translational Medicine, Faculty of Health Sciences & Ministry of Education Frontiers Science Center for Precision Oncology, University of Macau, Taipa, Macau, China College of Biosystems Engineering and Food Science Key Laboratory of Intelligent Equipment and Robotics for Agriculture of Zhejiang Province Zhejiang University Hangzhou 310058 P. R. China Nanosystem Research Institute (NRI), National Institute of Advanced Industrial Science and Technology (AIST), Central 5, 1-1-1 Higashi, Tsukuba, Ibaraki 305-8565, Japan; Key Laboratory of Materials Physics, Anhui Key Laboratory of Nanomaterials and Nanotechnology, Institute of Solid State Physics, Chinese Academy of Sciences, Hefei 230031, People’s Republic of China School of Medicine, Tsinghua University Beijing China Harbin Medical University Cancer Hospital, Harbin, China Department of Food Science and Human Nutrition University of Illinois at Urbana‐Champaign 905 South Goodwin Avenue Urbana IL 61801 Ecological Environment Bureau of the Changchun Jingyue Economic Development Zone, Changchun 130118, People's Republic of China Public Health Sciences, Division of Health Policy and Outcomes Research Beijing Key Laboratory of Bioelectromagnetics, Institute of Electrical Engineering, Chinese Academy of Sciences, Beijing 100190, China Department of Chemical and Biological Engineering; University at Buffalo; The State University of New York; Buffalo; USA Department of Respiratory Diseases, Qingdao Haici Hospital, Qingdao, Shandong, China Institute of Chinese Materia Medica Shanghai University of Traditional Chinese Medicine Shanghai P. R. China Department of Traumatic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201 From the Lipid Research Group, School of Medical Sciences, University of New South Wales Sydney, Australia (B.J.W., Y.S., K.-L.O., Y.L., S.T., P.J.B., K.-A.R.) Department of Biomedical Engineering, Medical School, Tsinghua University, Beijing 100084, China. liyue01@mails.tsinghua.edu.cn Department of Computer Science, University of Saskatchewan, Saskatoon, Saskatchewan S7N 5C9, Canada. Department of Biology, Southern University of Science and Technology, Shenzhen, Guangdong 518055, China State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, Harbin 150090, China Department of Neurology, Beijing Chaoyang Hospital, Capital Medical University , No. 8, South Gongti Road , Beijing 100020 , China Key Laboratory of Marine New Materials and Related Technology, Zhejiang Key Laboratory of Marine Materials and Protection Technology, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo 315201, China; School of Materials Science and Engineering, Jiangsu Collaborative Innovation Center for Photovoltic Science and Engineering, Jiangsu Province Cultivation Base for State Key Laboratory of Photovoltaic Science and Technology, Changzhou University, Changzhou 213164, China Deparrncnt of Physiology, Dulian Medical University, Dalian 116027, China. Intensive Care Unit, General Hospital of The Southern Theatre Command of The People's Liberation Army, Guangzhou, Guangdong 510010, P.R. China Department of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China Department of Digestive Medicine, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, China. Nanchang University, Nanchang, Jiangxi, People’s Republic of China Key Laboratory of Bioorganic Synthesis of Zhejiang Province, College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310014, China Tianjin University of Traditional Chinese Medicine, Tianjin, China Key Lab of Synthetic and Biological Colloids, Ministry of Education, School of Chemical and Material Engineering, International Joint Research Laboratory for Biointerface and Biodetection State Key Lab of Food Science and Technology School of Food Science and Technology Jiangnan University Wuxi Jiangsu 214122 P. R. China Department of Pathology, Shengjing Hospital, China Medical University, Shenyang, P.R. China Division of i-Lab & Key Laboratory for Nano-Bio Interface Research; Suzhou Institute of Nano-Tech & Nano-Bionics; Chinese Academy of Sciences; Suzhou, China Contribution from the Department of Chemistry, University of North Carolina, Chapel Hill, North Carolina 27599-3290 CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety National Center for Nanoscience and Technology Beijing 100190 China Division of Health Policy and Outcomes Research Department of Public Health Sciences University of Rochester Medical Center Rochester New York USA Department of Chemical and Biological Engineering; University at Buffalo (SUNY); Buffalo, USA College of Food Science & Technology, Hebei Normal University of Science and Technology, Qinhuangdao 066004, China Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan 430074, China Department of Respiratory Diseases, Qingdao Haici Hospital , Qingdao, China MOE Key Laboratory of Major Diseases in Children National Key Discipline of Pediatrics (Capital Medical University) National Clinical Research Center for Respiratory Diseases Beijing Key Laboratory of Pediatric Respiratory Infection Diseases Beijing Pediatric Research Institute Beijing Children’s Hospital Capital Medical University National Center for Children’s Health China 4School of Medical Technology and University of Iowa, Iowa City, IA, USA Department of Biochemistry and Molecular Biology, Molecular Medicine and Cancer Research Center, Chongqing Medical University, Chongqing, China. College of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen 518060, P. R. China Department of Emergency and Critical Care Medicine, Jiading District Central Hospital Affiliated Shanghai University of Medicine & Health Sciences, Shanghai, China. Department of Cardiology, Jiading District Central Hospital Affiliated Shanghai University of Medicine & Health Sciences, Shanghai, China. Department of Food Science and Engineering, Institute of Food Safety and Nutrition, Jinan University, Guangzhou 510632, China Dept. of Prosthodontics Technology, West China School of Stomatology, Sichuan University, Chengdu 610041, China. Guangzhou Institute of Pediatrics Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangdong Provincial Clinical Research Center for Child Health Guangzhou China Faculty of Arts Shenzhen University Shenzhen China Key Laboratory Medical Molecular Virology, MoE/MoH, and the Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai 200032, China Department of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College , Beijing, P. R. China School of Chemical Engineering, Sichuan University of Science & Engineering, Zigong, Sichuan, China; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, Yunnan, China College of Public Administration, Guizhou University of Finance and Economics, Guizhou 550025, China Key Lab of Polyoxometalate Science of Ministry of Education; Faculty of Chemistry; Northeast Normal University; Changchun 130024; P. R. China Key Laboratory of Agricultural Environment, Ministry of Agriculture and Rural Affairs, Institute of Environment and Sustainable Development in Agriculture Chinese Academy of Agricultural Sciences Beijing China School of Electrical & Electronic Engineering, Tianjin Key Laboratory of Film Electronic & Communication Devices, Tianjin University of Technology, Tianjin, 300384, China College of Resources and Environmental Science, Northeast Agricultural University, Harbin 150030, China Department of Chemistry Kyoto University, Kitashirakawa-Oiwake-cho, Sakyo-ku, Kyoto-shi Kyoto 606-8502 Japan Department of Chemistry, Graduate School of Science, Kyoto University, Kitashirakawa-Oiwakecho, 606-8502 Kyoto, Japan School of Mechanical Engineering, Hefei University of Technology, Hefei, China College of Animal Science and Veterinary Medicine Heilongjiang Bayi Agricultural University Daqing China Department of Basic Neurosciences, Faculty of Medicine, University of Geneva Department of Neurology, Beijing Chaoyang Hospital Affiliated to Capital Medical University, Beijing, China i-Lab and Key Laboratory of Multifunctional Nanomaterials and Smart Systems, Suzhou Institute of Nano-Tech and Nano-Bionics (SINANO), Chinese Academy of Sciences (CAS), 398 Ruoshui Road, Suzhou 215123, P. R. China Department of Chemistry Graduate School of Science Kyoto University Kitashirakawa-oiwakecho Sakyo-ku Kyoto 606-8502 Japan Department and Institute of Psychology, Ningbo University, Ningbo, China; KunMing Health Vocational College, KunMing, China School of Food & Wine Ningxia University Yinchuan China Department of Public Health Sciences, University of Rochester School of Medicine and Dentistry, Rochester, NY Department of Chemistry, University of Southern California, Los Angeles, California 90089, United States GlaxoSmithKline, 709 Swedeland Road, King of Prussia, Pennsylvania 19406 Beijing Advanced Innovation Center for Tree Breeding by Molecular Design, College of Biological Sciences and Technology, Beijing Forestry University, No. 35, Qinghua East Road, Beijing 100083, P. R. China; National Engineering Laboratory for Tree Breeding, College of Biological Sciences and Technology, Beijing Forestry University, No. 35, Qinghua East Road, Beijing 100083, P. R. China; Key Laboratory of Genetics and Breeding in Forest Trees and Ornamental Plants, Ministry of Education, College of Biological Sciences and Technology, Beijing Forestry University, No. 35, Qinghua East Road, Beijing 100083, P. R. China College of Software Nankai University 94 Weijin Road Nankai District 300071 China Department of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China College of Environmental Science and Engineering, and Key Laboratory of Environmental Biology and Pollution Control, Ministry of Education, and State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan University, Changsha 410082, People’s Republic of China, and School of Environment and Chemical Engineering, Nanchang Hangkong University, Nanchang 330063, People’s Republic of China Department of Plastic and Aesthetic Surgery, Nanfang Hospital of Southern Medical University, Guangzhou, Guangdong Province 510515, China. Department of Dermatology The Third Affiliated Hospital of Soochow University Changzhou China Department of Chemistry, The Scripps Research Institute & UF Scripps Biomedical Research, 130 Scripps Way, Jupiter, Florida 33458, United States Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, 209 Tongshan Road, Xuzhou 221004, Jiangsu, China State Key Laboratory of Dairy Biotechnology, Technology Center of Bright Dairy and Food Company Ltd., Shanghai 200436, People’s Republic of China; Key Laboratory of Food Colloids and Biotechnology, Ministry of Education, School of Food Science and Technology, Jiangnan University, Wuxi 214122, People’s Republic of China Department of Pharmacy; Beijing Friendship Hospital; Capital Medical University; Beijing; China Key Lab of Polyoxometalate Science of Ministry of Education; Northeast Normal University; Changchun; China Department of Public Health Sciences University of Rochester School of Medicine and Dentistry Rochester New York Department of Respiratory Medicine, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, Sichuan, P. R. China; Department of Macromolecular Science and Engineering, Case Western Reserve University, Cleveland, Ohio 44106-7202, United States Institute of Intelligent Computing, Zhejiang Lab, Hangzhou 311121, China Department of Clinical Laboratory, Beijing Ditan Hospital, Capital Medical University, Beijing, China; School of Computer Science and Engineering Sun Yat‐sen University Guangzhou China; Guangdong Province Key Laboratory of Computational Science Sun Yat‐sen University Guangzhou China School of Materials Science and Engineering College of Science China University of Petroleum (East China) Qingdao Shandong 266580 China Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences,Xi'an Jiaotong University Health Science Center,Xi'an,China; Key Laboratory of Environment and Genes Related to Diseases,Xi'an Jiaotong University, Ministry of Education of China,Beijing,China Computer Science and Artificial Intelligence LabMassachusetts Institute of Technology Cambridge Massachusetts AECC Beijing Institute of Aeronautical Materials; Beijing 100095; China; Beijing Institute of Graphene Technology; Beijing 100094 LSU Museum of Natural Science, Department of Biological Sciences Louisiana State University Baton Rouge Louisiana USA Department of Nutrition and Food Hygiene, School of Public Health and Management, Chongqing Medical University Key Laboratory of Applied Surface and Colloid Chemistry of MOE, Key Laboratory of Macromolecular Science of Shaanxi Province, School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi’an 710119, China Department of Public Health Sciences URMC Rochester New York National Engineering Research Center of Electromagnetic Radiation Control Materials, School of Electronic Science and Engineering, University of Electronic Science and Technology of China, Chengdu 611731, China; State Key Laboratory of Electronic Thin Films and Integrated Devices, University of Electronic Science and Technology of China, Chengdu 611731, China Department of Nursing, Yantai Yuhuangding Hospital, Yantai, Shandong, China School of Basic Medicine, Shanxi Medical University, Taiyuan, 030001, China Department of Cardiac Surgery, Air Force General Hospital of People’s Liberation Army, Beijing, China (Y.L.). Department of Endocrinology of the Fifth People’s Hospital of Shanghai and the Molecular and Cell Biology Lab of the Institutes of Biomedical Sciences Fudan University Shanghai China The First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou 510407, China; Lingnan Medical Research Center, Guangzhou University of Chinese Medicine, Guangzhou 510407, China; Key Laboratory of Chronic Heart Failure, Guangzhou University of Chinese Medicine, Guangzhou 510407, China 1 Department of Computer Science, 2The Donnelly Centre, University of Toronto, Toronto, Ontario M5S 3E1, 3Genetics and Genome Biology, SickKids Research Institute, Toronto, Ontario M5G 1L7 and 4Banting and Best Department of Medical Research and Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 3E1, Canada; 1 Department of Computer Science, 2The Donnelly Centre, University of Toronto, Toronto, Ontario M5S 3E1, 3Genetics and Genome Biology, SickKids Research Institute, Toronto, Ontario M5G 1L7 and 4Banting and Best Department of Medical Research and Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 3E1, Canada College of Chemical Engineering and Environmental Chemistry, Weifang University, Weifang, 261061, China Rutgers Cancer Institute of New Jersey and Department of Pharmacology, Robert Wood Johnson Medical School, Rutgers, the State University of New Jersey, New Brunswick, NJ 08903, USA Key Lab of Materials Physics Anhui Key Lab of Nanomaterials and Nanotechnology Institute of Solid State Physics Chinese Academy of Sciences Hefei 230031 P.R. China College of Animal Sciences, Jilin University, Changchun 130062, China Gastroenterology Guangzhou Medical University Guangzhou China Key Laboratory for Modern Design & Rotor-Bearing System, School of Mechanical Engineering, Xi’an Jiaotong University, Xi’an, China Department of Laboratory, Jinhua People’s Hospital, China; Key Lab of Agro-Biotechnology, College of Agronomy, Xinjiang Agricultural University, Urumqi 830052, China. Department of Computer Science, University of Toronto, Toronto, ON, M5S 3G4, Canada; The Donnelly Centre, University of Toronto, Toronto, ON, M5S 3E1, Canada; Present address: Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, P.R. China. Department of Public Health Sciences, Division of Health Policy and Outcomes Research, University of Rochester Medical Center , Rochester, New York, United States of America Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing Medical University Nanjing, China. Department of Internal Medicine, University of Iowa Carve College of Medicine 2000 Medical Laboratories 25 South Grand Avenue, Iowa City, IA 52242, USA. Materials Science Division Argonne National Laboratory Lemont IL 60439 USA Department of Gastroenterology Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences Beijing China Institute of Animal Science, Jiangsu Academy of Agricultural Sciences, Nanjing, China Institute of Infectious Diseases, Beijing Ditan Hospital, Beijing 100011, China. Department of Gastroenterology Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Science Beijing China State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi 214122, People’s Republic of China Department of Community and Family Medicine, and; Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, North Carolina, USA Department of Chemistry, Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Beijing Key Laboratory for Microanalytical Methods and Instrumentation, Tsinghua University, Beijing 100084, China Department of Anesthesiology Key Laboratory of Materials Physics, Anhui Key Laboratory of Nanomaterials and Nanotechnology, Institute of Solid State Physics, Chinese Academy of Sciences, Hefei 230031, Anhui, PR China Department of Gastroenterology and Endoscopy, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning 11000, P.R. China Non‐Destructive Detection Laboratory of Agricultural Products, School of Agriculture Ningxia University Yinchuan 750021 China College of Forestry and Landscape Architecture, South China Agricultural University, Guangzhou 510642, China; Guangdong Key Laboratory for Innovative Development and Utilization of Forest Plant Germplasm, Guangzhou 510642, China Department of Hepatology Division 3, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, P.R. China Department of Pathology Tianjin Medical University Tianjin China Department of Microbiology and Immunology, Western University, London, ON N6A 3K7, Canada Division of Developmental and Clinical Immunology, Departments of Medicine, Pediatrics, and Microbiology, University of Alabama, and the Howard Hughes Medical Institute, Birmingham, AL 35294; University of South Florida, All Children’s Hospital, St. Petersburg, FL 33701; Department of Pathology, Immunology, and Laboratory Medicine, University of Florida College of Medicine, Gainesville, FL 32610; and Biologie Moléculaire et Cellulaire du Développement, Centre National de la Recherche ... The State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, The People's Republic of China. Department of Public Health Sciences University of Rochester Rochester NY Department of Genetics and Molecular Biology, Xi’an Jiaotong University College of Medicine, Xi’an, Shaanxi 710061, PR China; Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, Xi’an, Shaanxi 710061, PR China Beijing Advanced Innovation Center for Tree Breeding by Molecular Design, National Engineering Laboratory for Forest Tree Breeding, College of Biological Sciences and Technology, Beijing Forestry University, Beijing 100083, PR China College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu, 610065, Sichuan, People’s Republic of China School of Pharmacy, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China. Key Laboratory of Theoretical Chemistry of Environment, Ministry of Education, School of Chemistry, South China Normal University, Guangzhou 510006, People’s Republic of China Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan 48824, and Macromolecular Crystallography Laboratory, National Cancer Institute, Post Office Box B, Frederick, Maryland 21702 From the Department of Pediatrics, Division of Hematology/Oncology, and the Program in Developmental Biology, Program in Genetics and Genomic Biology, Research Institute, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada; and the Department of Molecular and Medical Genetics, University of Toronto, Toronto, ON, Canada. Department of Neuroscience & Experimental Therapeutics Texas A&M University College Station Texas USA State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, 27 Tai-Ping Road, Beijing 100850, China Laboratory of Translational Medicine Jiangsu Academy of Traditional Chinese Medicine Nanjing Jiangsu Province China Department of Ultrasound, Chinese PLA General Hospital, Beijing 100853, China. liyue301@126.com Department of Chemistry and Biochemistry University of Maryland College Park MD 20742 USA Department of Orthopaedics The First Affiliated Hospital of Guangzhou University of Chinese Medicine Guangzhou Guangdong China College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, P. R. China The Animal Experimental Centre, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China Department of Cardiology, First Clinical College, Harbin Medical University, Harbin 150001, China. ly99ly@public.hr.hl.cn Department of Ophthalmology, Henry Ford Medical Center, West Bloomfield, Michigan. Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, 210029, China; Key Laboratory of Hematology of Nanjing Medical University, Nanjing, 210029, China; Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing, 210029, China Russell H. Morgan Department of Radiology and Radiological Science The Johns Hopkins University School of Medicine Baltimore Maryland USA; AnatomyWorks, LLC Ellicott City Maryland USA Department of Dermatology State Key Laboratory of Biotherapy and Cancer Center National Clinical Research Center for Geriatrics West China Hospital Sichuan University Chengdu 610041 China Department of Molecular Diagnostics, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong, China Key Laboratory of Materials Physics, Anhui Key Laboratory of Nanomaterials and Nanotechnology, Institute of Solid State Physics, Chinese Academy of Sciences, Hefei 230031, Anhui, People’s Republic of China Department of Dermatology, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital and West China School of Pharmacy, Sichuan University, Chengdu 610041, P. R. China College of Computer Science, KLMDASR, Key Laboratory for Medical Data Analysis and Statistical Research Nankai University Tianjin China Department of Gynecology and Obstetrics, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 201999, P.R. China Laboratory of Clinical Pharmacokinetics, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China; State Key Laboratory of Microbial Resources Institute of Microbiology Chinese Academy of Sciences Beijing 100101 China Department of Gastroenterology Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College Beijing China Department of Pathology, Shengjing Hospital of China Medical University, Shenyang, 110004, China College of Water & Architectural Engineering, Shihezi University, Shihezi 832000, Xinjiang, China. Key Laboratory of Material Physics, Anhui Key Laboratory of Nanomaterials and Nanotechnology, Institute of Solid State Physics, Chinese Academia of Sciences, Hefei, 230031, Anhui, P. R. China Pathology Department, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, China. State Key Laboratory of Protein and Plant Gene Research, School of Advanced Agricultural Sciences and School of Life Sciences, Peking University, 100871 Beijing, China; Department of Ophthalmology, Xijing Hospital, Fourth Military Medical University, Xi'an, People's Republic of China Sydney Pharmacy School, The University of Sydney, Camperdown, Australia Key Laboratory of Molecular Biology in High Cancer Incidence Coastal Chaoshan Area of Guangdong Higher Education Institutes Shantou University Medical College China; Department of Biochemistry and Molecular Biology Shantou University Medical College China Department of Biochemistry and Molecular Biology and Department of Chemistry, Michigan State University, East Lansing, Michigan 48824 School of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou 310018, China Department of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China. The First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, P.R.China; Lingnan Medical Research Center, Guangzhou University of Chinese Medicine, Guangzhou, P.R.China; University Key Laboratory of Traditional Chinese Medicine Prevention and Treatment of Chronic Heart Failure, Guangdong Province, Guangzhou University of Chinese Medicine, Guangzhou, P.R.China; Guangzhou Key Laboratory for Chinese Medicine Prevention and Treatment of Chronic Heart Failure, Guangdong Province, Guangzhou University of Chinese Medicine, Guangzhou, P.R.China Department of Pharmaceutical Engineering School of Chemistry and Chemical Engineering South China University of Technology Guangzhou China Department of Computer Science University of Toronto Toronto Ontario Canada; Donnelly Centre for Cellular and Biomolecular Research University of Toronto Toronto Ontario Canada From the Department of Anesthesiology (L.G.G., E.F., S.J.L., M.P.E.) and the Department of Public Health Sciences (L.G.G., Y.L.), University of Rochester School of Medicine, Rochester, New York; RAND Health, Boston, Massachusetts (L.G.G., A.W.D.); and U.S. Anesthesia Partners, Dallas, Texas (R.P.D.). Department of Public Health Sciences, University of Rochester, NY, USA School of Traditional Chinese Medicine Beijing University of Chinese Medicine Beijing China College of Food Science and Engineering, Ocean University of China, No. 5 Yushan Road, Qingdao 266003, P. R. China Department of Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, 150081, China Sino‐French Institute for Earth System Science College of Urban and Environmental Sciences Peking University Beijing 100871 China Macromolecular Crystallography Laboratory, National Cancer Institute, Frederick, Maryland 21702, and Department of Biochemistry, Michigan State University, East Lansing, Michigan 48824 State Key Laboratory of Marine Resource Utilization in South China Sea, School of Materials Science and Engineering, Hainan University, Haikou 570228, Hainan, China Department of Cardiology, The First Affiliated Hospital, Harbin Medical University, Harbin, China Departments of Biochemistry, The Ohio State University, Columbus, Ohio 43210 Jiangsu Provincial Key Laboratory of Geriatrics, Department of Geriatrics, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China Sydney Pharmacy School, The University of Sydney, Sydney, New South Wales 2006, Australia WuXi NextCODE, Shanghai, People’s Republic of China; Department of Dermatology, Xinhua Hospital Shanghai Jiaotong University School of Medicine Shanghai China; Institute of Dermatology Shanghai Jiaotong University School of Medicine Shanghai China Key Lab of Materials Physics, Anhui Key lab of Nanomaterials and Nanotechnology, Institute of Solid State Physics, Chinese Academy of Sciences, Hefei, 230031, Anhui, P. R. China School of Basic Medical Science, Kunming Medical University, Kunming, Yunnan, People’s Republic of China The First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, China; Lingnan Medical Research Center, Guangzhou University of Chinese Medicine, Guangzhou, China; University Key Laboratory of Traditional Chinese Medicine Prevention and Treatment of Chronic Heart Failure, Guangdong Province, Guangzhou, China School of Clinical Medicine, Southwest Medical University, Luzhou, Sichuan, China, 646000 State Key Laboratory of Food Science and Technology; Jiangnan University; Wuxi; People's Republic of China; International Joint Research Laboratory for Biointerface and Biodetection School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang, 212013, China 1Department of Biochemistry and Molecular Biology, 2Key Laboratory of Environment and Genes Related to Diseases, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Centre, Xi'an710061, China. E-mail: lilyld.980@stu.xjtu.edu.cn. Institute of New Carbon Materials; Taiyuan University of Technology; Taiyuan 030024; China Department of Integrated Chinese and Western Medicine, Yantai Yuhuangding Hospital, Shandong, China Department of Anesthesiology, The First Affiliated Hospital of Harbin Medical University College of Animal Science and Technology, Heilongjiang Bayi Agricultural University, Daqing 163319. Information and Communication Technologies Centre, Commonwealth Scientific and Industrial Research Organisation , Marsfield, New South Wales 2122, Australia Key Laboratory of Standardisation of Chinese Medicines of Ministry of Education, Institute of Chinese Materia Medica Shanghai University of Traditional Chinese Medicine Shanghai China General Internal Medicine Department, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, China State Key Laboratory of Metastable Materials Science and Technology, Hebei Key Laboratory of Nano-Biotechnology, Yanshan University, Qinhuangdao 066004, P. R. China Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland Department of Biomedical Engineering, Medical School, Tsinghua University, Beijing, China University of Rochester Medical Center, Rochester, NY, USA College of Horticulture and Forestry Huazhong Agricultural University Wuhan 430070 China Department of Oncology, The 174th Hospital of the Chinese People's Liberation Army, The Affiliated Chenggong Hospital of Xiamen University, Xiamen, Fujian 361003, P.R. China Department of Chemistry, W. M. Keck Institute for Proteomics Technology and Applications, George Washington University, Washington, D.C. 20052 Health Management Center Sichuan Academy of Medical Sciences·Sichuan People's Hospital Chengdu China Department of Cardiology The First Affiliated Hospital of Harbin Medical University Harbin Heilongjiang China Hebei Key Laboratory of State Key Laboratory of Metastable Materials Science and Technology, Yanshan University, Qinhuangdao, 066004, China State Key Laboratory of Food Science and Technology Jiangnan Univ. Wuxi Jiangsu 214122 People's Republic of China; Int. Joint Research Laboratory for Biointerface and Biodetection, and School of Food Science and Technology Jiangnan Univ. Wuxi Jiangsu 214122 People's Republic of China State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Anesthesia, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China. Confocal Microscopy CoreDell Pediatric Research InstituteThe University of Texas at AustinAustinTexasUSA Department of Public Health Sciences University of Rochester Medical Center Rochester New York School of Chemistry and Chemical Engineering; State Key Laboratory of Metal Matrix Composites; Shanghai Jiao Tong University; Shanghai; P. R. China Pathology Centre, Shanghai First People's Hospital; Shanghai Jiao Tong University School of Medicine; Shanghai PR China Department of Gastroenterology Nanfang Hospital, Southern Medical University Guangzhou China Nursing Department Beijing Tongren Hospital Capital Medical University Beijing China Jilin University 1 Institute of Theoretical Chemistry, State Key Laboratory of Theoretical and Computational Chemistry, , Changchun 130023, China Department of Neurosurgery Xijing Hospital The Fourth Military Medical University Xi'an China State Key Laboratory of Inorganic Synthesis and Preparative Chemistry College of Chemistry Jilin University Changchun 130012 P. R. China Laboratory of Pathology Hebei Medical University Shijiazhuang China Department of Public Health Sciences, University of Rochester School of Medicine and Dentistry, New York Inner Mongolia Key Laboratory of Chemistry and Physics of Rare Earth Materials School of Chemistry and Chemical Engineering Inner Mongolia University Huhhot Inner Mongolia China Department of Ultrasound Medicine, Laboratory of Ultrasound Molecular Imaging, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou 510150, China; Experimental Center, The Liwan Hospital of the Third Affiliated Hospital of Guangzhou Medical University, Guangzhou 510176, China Department of Microbiology and Immunology, Schulich School of Medicine & Dentistry, University of Western Ontario, London, Canada School of Clinical Medicine, Dali University, Dali, Yunnan 671000, P. R. China Department of Lung Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin Lung Cancer Center, Tianjin 300060, P.R. China Beijing International Studies University (BISU), Beijing 100048, China Institute of Medicinal Plant Development,Chinese Academy of Medicinal Sciences & Peking Union Medicinal College Beijing 100193,China Key Laboratory of Bioactive Substances and Resources Utilisation of Chinese Herbal Medicine,Ministry of Education Beijing 100193,China. School of Space and Environment, Beihang University, Beijing 100191, China Beijing Advanced Innovation Center for Tree Breeding by Molecular Design, National Engineering Laboratory for Forest Tree Breeding, College of Biological Sciences and Technology, Beijing Forestry University, Beijing 100083, People’s Republic of China College of Resources and Environment, Southwest University, Chongqing 400715, China. Chongqing Research Center for Agricultural Non-point Source Pollution Control Engineering in the Three Gorges Reservoir Area, Chongqing 400715, China. Key Laboratory of Jiangxi Province for Persistant Pollutants Control and Resources Recycle, Nanchang Hangkong University, Nanchang, 330063, P. R. China Key Laboratory of Materials Physics and Anhui Key Laboratory of Nanomaterials and Nanotechnology, Institute of Solid State Physics, Chinese Academy of Sciences, Hefei, Anhui 230031, People’s Republic of China From the Laboratory of Cardiovascular Science, Gerontology Research Center, National Institute on Aging, Baltimore, Md. Shandong Provincial Key Laboratory of Depositional Mineralization & Sedimentary Minerals, College of Geosciences and Engineering, Shandong University of Science and Technology, Qingdao 266510, China. lyysy_79@163.com Lab of Translational Medicine, Jiangsu Province Academy of Traditional Chinese Medicine, 210028 Nanjing, P.R. China Beijing Institute of Radio Measurement, Beijing 100039, China College of Life Sciences and Technology Jinan University Guangzhou 510632 China; Key Laboratory of Eutrophication and Red Tide Prevention of Guangdong Higher Education Institutes Guangzhou 510632 China Graduate School, Beijing University of Chinese Medicine Beijing 100029, China Department of Oncology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences Beijing 100053, China. Department of Molecular Medicine, Institute of Biotechnology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78245; and Physical Electronics Laboratory, Wolfgang-Pauli-Strasse 16, ETH Zurich, 8093 Zürich, Switzerland From the Key Laboratory of Molecular Biophysics of the Ministry of Education, Cardio-X Institute (Y.B., G.J., Yingchao Zhou, M.Z., Yuanyuan Zhao, S.L., F.W., Q. Lu, Y.H., Q.Y., T.K., H.L., X.R., C.X., X.T., Q.K.W.), and College of Life Science and Technology and Center for Human Genome Research, Institute of Cardiology (S.N., X.C., Y. Liao), Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Department of Cardiology, Jining Medical College Affiliated... School of Biology and Basic Medical Sciences Soochow University Suzhou China Department of Medical Oncology, The Fourth Affiliated Hospital of China Medical University, Shenyang, China School of Medicine and Health, Harbin Institute of Technology, Yi Kuang Jie 2, Harbin 150080, China. Division of Health Policy and Outcomes Research Department of Community and Preventive Medicine University of Rochester Medical Center Rochester NY Department of Cardio‐Thoracic Surgery The First Affiliated Hospital of Guangxi Medical University Nanning China College of Chemistry and Chemical Engineering, Central South University, Changsha, PR China; Center for Environment and Water Resources, Central South University, Changsha, PR China; Key Laboratory of Hunan Province for Water Environment and Agriculture Product Safety, Changsha, PR China College of Chemistry & Environment South China Normal University Guangzhou 510006, Guangdong P. R. China CAS Key Laboratory for Biomedical Effects, of Nanomaterials and Nanosafety National Center for Nanoscience and Technology Beijing 100190 P.R. China Division of endocrinology, The Renhe Hospital of Three Gorges University, Yichang, Hubei, P.R. China Department of Chemistry and Biochemistry University of California Santa Barbara CA 93106 USA Aerospace Central Hospital, Beijing, China. Toronto Rehabilitation Institute, University Health Network, Toronto, Canada Department of Cardiology, the First Affiliated Hospital of Harbin Medical University, China (Y.L.). Key Laboratory of Molecular Microbiology and Technology Ministry of Education College of Life Sciences Nankai University Tianjin China; Department of Microbiology and Immunology Western University London ON Canada Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing 100071, China. College of Animal Science and Veterinary Medicine, Jilin University, Changchun, People's Republic of China Department of Clinical Pharmacy, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, China College of Chemistry and Key Laboratory of Advanced Energy Materials Chemistry (Ministry of Education) Nankai University Tianjin 300071 P. R. China Department of Laboratory, The Second Affiliated Hospital of Chongqing Medical Univerity; Yuzhong District Chongging, China Department of Chemical and Biological Engineering, University at Buffalo (SUNY), Buffalo, New York 14260, United States From the Departments of Radiology (Y.S., Ying Liu, Yanqing Liu, Q.G.), Pancreato-thyroidic Surgery (F.G.), and Pathology (Yue Li), Shengjing Hospital, China Medical University, No. 36 Sanhao St, Heping District, Shenyang 110004, P.R. China; and Department of Radiology, Mayo Clinic, Rochester, Minn (S.T., K.J.G., R.L.E.). Beijing Centre For Physical & Chemical Analysis, Beijing 100050, China. Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, Jiangsu 210029, China; Key Laboratory of Hematology of Nanjing Medical University, Nanjing, Jiangsu 210029, China; Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing, Jiangsu 210029, China Center for Brain and Cognitive Sciences and Department of Psychology Peking University Beijing 100871 China School of Polymer Science & Engineering, Qingdao University of Science & Technology, Qingdao 266101, China Toronto Rehabilitation Institute, University Health Network, Toronto, ON, Canada Center for Infectious and Inflammatory Disease, Institute of Biosciences and Technology, Texas A&M University System Health Science Center, Houston, TX, USA Department of Prosthodontics Peking University School and Hospital of Stomatology Beijing China Department of Public Health Sciences University of Rochester Rochester New York USA School of Science Xihua University Chengdu P. R. China Key Laboratory for Applied Technology of Sophisticated Analytical Instruments of Shandong Province, Shandong Analysis and Test Center, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250014, China; School of Pharmaceutical Sciences, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250014, China Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing 210029, China Sports Medicine Service, Beijing Jishuitan Hospital, Xicheng District, Beijing, Republic of China Department of Oncology, The Affiliated Hospital of Southwest Medical University, Luzhou, China Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, China; Key Lab of Materials Physics, Institute of Solid State Physics, Chinese Academy of Science, Hefei, 230031, Anhui, P.R. China, Department of Nuclear and Quantum Engineering, Korea Advanced Institute of Science and Technology (KAIST), 373-1 Guseong, Yuseong, Daejeon, 305-701, South Korea, and Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Science (CAS), Ningbo city, 315040, Zhejiang, P.R. China Kunming Key Laboratory of Molecular Biology for Sinomedicine, Faculty of Basic Medicine, Yunnan University of Traditional Chinese Medicine, Kunming 650500, China Division of i‐Lab & Key Laboratory for Nano‐Bio Interface Research Suzhou Institute of Nano‐Tech & Nano‐Bionics Chinese Academy of Sciences Suzhou Jiangsu 215123 China; Department of Chemistry College of Sciences Shanghai University Shanghai 200444 China School of Medical Technology, Xuzhou Medical University, Xuzhou, People's Republic of China School of Pharmacy, Jiangsu University, Zhenjiang, 212013, People’s Republic of China Key Laboratory of Microelectronic Devices and Integrated Technology Institute of Microelectronics Chinese Academy of Sciences Beijing 100029 China; University of Chinese Academy of Sciences Beijing 100049 China University of Rochester, Department of Public Health Sciences, NY, USA School of Chemistry and Chemical Engineering Frontiers Science Center for Transformative Molecules State Key Laboratory of Metal Matrix Composites Shanghai Jiao Tong University Shanghai P. R. China Laboratory of Translational Medicine, Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing 210028, Jiangsu Province, P.R.China Hubei Hongshan Laboratory, Hubei Engineering Technology Research Center for Forestry Information, College of Horticulture and Forestry Sciences, Huazhong Agricultural University , Wuhan 430070 , China 1Department of Experimental Research, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China. Institute of Nuclear and New Energy Technology, Tsinghua University, Beijing 100084, People's Republic of China Wuhan National Laboratory for Optoelectronics Huazhong University of Science and Technology Wuhan 430074 China; National Center for Magnetic Resonance in Wuhan, State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics Wuhan Institute of Physics and Mathematics Wuhan 430071 China Department of Geography and Resource Management, The Chinese University of Hong Kong, Sha Tin 999077, Hong Kong, China; Institute of Environment, Energy and Sustainability, The Chinese University of Hong Kong, Sha Tin 999077, Hong Kong, China Division of Health Policy and Outcomes Research, Department of Public Health Sciences, University of Rochester School of Medicine and Dentistry Key Laboratory of Functional Inorganic Material Chemistry Ministry of Education of the People's Republic of China Heilongjiang University Harbin 150080 China Department of Cardiology, the First Affiliated Hospital, Harbin Medical University, Harbin, Heilongjiang Province, China;; Key Laboratory of Cardiac Diseases and Heart Failure, Harbin Medical University, Harbin, Heilongjiang Province, China; and Department of Lung Cancer Tianjin Medical University Cancer Institute and Hospital, China; Tianjin Medical University Cancer Institute and Hospital National Clinical Research Center for Cancer, China; Key Laboratory of Cancer Prevention and Therapy, China; Tianjin’s Clinical Research Center for Cancer, China Department of Experimental Research, Sun Yat‐sen University Cancer Center, State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Guangzhou China Department of Immunology, School of Basic Medical Sciences, Shandong University, Jinan, Shandong, P. R. China Guangzhou University of Chinese Medicine, Guangzhou, China Department of Digestive Medicine Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences Beijing China Academy of Orthopedics, Guangdong Province, Guangdong Provincial Key Laboratory of Bone and Joint Degenerative Diseases, Guangzhou, China; Department of Treatment, Center for Traumatic Injuries, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China; Department of Intensive Care Unit, General Hospital of Southern Theatre Command of PLA, Guangzhou, China; Department of Emergency Medicine, Guangdong Second Provincial General Hospital, Guangzhou, China Department of Gastroenterology Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College Beijing China Harbin Medical University Cancer Hospital, No. 150 Haping Road, Nangang District, Harbin City, Heilongjiang Province, China 5Guangwai Community Health Service Center of Xicheng District, Beijing, China State Key Laboratory for Physical Chemistry of Solid Surfaces and Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, P. R. China Department of Oncology, First Affiliated Hospital of Yangtze University, Jingzhou, Hubei 434023, P.R. China Department of Ultrasound Medicine, Laboratory of Ultrasound Molecular Imaging, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou 510150, People’s Republic of China Department of Economics, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands Food Safety Key Laboratory of Zhejiang Province, School of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou 310018, China Senior Department of Otolaryngology-Head and Neck Surgery, the Sixth Medical Center of PLA General Hospital, Beijing, China Department of Ophthalmology, Institute of Ophthalmology of Chinese PLA, Xijing Hospital, Fourth Military Medical University, Xi'an, China. Department of Chemistry, Institute for Proteomics Technology and Applications, George Washington University, Washington, DC 20052 Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 201899, China; School of Materials and Chemistry, University of Shanghai for Science and Technology, Shanghai 200093, China College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China Department of Gastroenterology, Peking Union Medical College Hospital Chinese Academy of Medical Science and Peking Union Medical College Department of Epidemiology & Biostatistics & Ministry of Education Key Lab of Environment & Health, School of Public Health, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, Hubei 430030, PR China Department of Intensive Care Unit, General Hospital of Southern Theatre Command, Southern Medical University, Guangzhou, Guangdong, China School of Public Health, North China University of Science and Technology, Tangshan, China International Center for Quantum Design of Functional Materials (ICQD); Hefei National Laboratory for Physical Science at the Microscale; and Synergetic Innovation Center of Quantum Information and Quantum Physics; University of Science and Technology of China; Hefei State Key Laboratory and Institute of Elemento-Organic Chemistry College of Chemistry Haihe Laboratory of Sustainable Chemical Transformations Nankai University Tianjin 300071 China Sports Medicine Service Beijing Jishuitan Hospital Beijing China College of Biosystems Engineering and Food Science, Key Laboratory of Intelligent Equipment and Robotics for Agriculture of Zhejiang Province, Zhejiang University, Hangzhou 310058, China Department of Laboratory, Nanfang Hospital, Southern Medical University, Guangzhou, 510000, China Department of Nuclear and Quantum Engineering, Korea Advanced Institute of Science and Technology, Daejeon 305-701, Korea; Key Laboratory of Materials Physics, Institute of Solid State Physics, Chinese Academy of Sciences, Hefei 230031, Anhui, China School of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules, Shanghai Jiao Tong University, Shanghai 201306, China Institute of Animal Science, Jiangsu Academy of Agricultural Sciences , Nanjing, Jiangsu 210014 , China; Key Laboratory for Crop and Animal Integrated Farming of Ministry of Agriculture and Rural Affairs, Jiangsu Academy of Agricultural Sciences , Nanjing, Jiangsu 210014 , China Department of Electrical and Systems Engineering, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Electronic Engineering, Tsinghua University, Beijing 100084, People's Republic of China From the Division of Cardiovascular Medicine (Y.-P.X., B.C., P.S., A.G., Y.L., R.M.W., I.M.G., M.E.A., L.-S.S.), Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA; Department of Physiology (Y.-P.X., L.-C.W.), Anhui Medical University, Anhui, China; Department of Veterans Affairs Medical Center (K.Z., I.M.G.), Iowa City, IA. State Key Laboratory of Pathogen and Biosecurity Beijing Institute of Microbiology and Epidemiology Beijing China Department of Pathology, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, P.R. China Key Lab of Materials Physics, Anhui Key Lab of Nanomaterials and Nanotechnology, Institute of Solid State Physics, Chinese Academia of Sciences, Hefei, 230031, Anhui, P. R. China Department of General Surgery, Yangpu Hospital, Tongji University School of Medicine, Shanghai, 200090, People's Republic of China Howard Hughes Medical Institute and National Center for Behavioral Genomics, Department of Biology, Brandeis University, Waltham, MA 02454 Key Laboratory of Structure-Based Drug Design & Discovery of the Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China Department of Anesthesiology, First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, China. Department of Otolaryngology‐Head & Neck Surgery The Third Affiliated Hospital of Sun Yat‐sen University Guangzhou China Core facilities West China Hospital Sichuan University Chengdu 610041 P.R. China Department of Obstetrics Beijing Obstetrics and Gynecology Hospital Capital Medical University Beijing China Shanghai Biochip Co., Ltd. & National Engineering Center for Biochip at Shanghai, 151 Libing Road, Zhangjiang Hi-Tech Park, Pudong, Shanghai, 201203, People’s Republic of China Department of Epidemiology and Biostatistics, Key Laboratory for Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Sciences and Technology, Wuhan, Hubei 430030, China. College of Software Nankai University China Department of General Surgery, Renhe Hospital, Shanghai 200431, P.R. China Department of Gynecology The Hospital of Heilongjiang Province Nangang Branch Harbin Heilongjiang China College of Food Science and Engineering Bohai University Jinzhou Liaoning China Key Laboratory of Plant Protection Resources & Pest Management of the Ministry of Education College of Plant Protection, Northwest A&F University Yangling China Guangdong Province Key Laboratory of Forensic Genetics Guangzhou Forensic Science Institute Guangzhou P. R. China University of Rochester Medical Center; Department of Public Health Sciences; Rochester NY USA South China Botanical Garden, Chinese Academy of Sciences, Guangzhou, China Department of Histology and Embryology College of Basic Medicine Chongqing Medical University Chongqing P. R. China; Laboratory of Stem Cell and Tissue Engineering College of Basic Medicine Chongqing Medical University Chongqing P. R. China National and Local Joint Engineering Research Center of Biomedical Functional Materials School of Chemistry and Materials Science Nanjing Normal University Nanjing 210023 China School of Life Sciences Institute of Life Science and Green Development Hebei University Baoding 071002 China University of Rochester Medical Center, NY, USA Department of Histology and Embryology School of Basic Medical Sciences Department of Plastic and Aesthetic Surgery Nanfang Hospital of Southern Medical University Southern Medical University Guangzhou 510515 P. R. China Department of Cell Biology, State University of New York, Downstate Medical Center, Brooklyn, New York 11203 Department of Clinical Surgery, College of Veterinary Medicine, Northeast Agricultural University, Harbin, Heilongjiang 150000, P.R. China Department of Chemistry Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology Tsinghua University Beijing 100084 China Solar Energy Conversion Center, Key Laboratory of Photoelectronic Thin Film Devices and Technology of Tianjin, Engineering Research Center of Thin Film Photoelectronic Technology of Ministry of Education, Institute of Photoelectronic Thin Film Devices and Technology, Nankai University, Tianjin 300350, P.R. China 1 Department of Computer Science and 2 Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario, Canada, 3 CEMSE Division, King Abdullah University of Science and Technology, Thuwal, Jeddah, K.S.A., 4 Banting and Best Department of Medical Research and 5 Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada; 1 Department of Computer Science and 2 Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario, Canada, 3 CEMSE Division, King Abdullah University of Science and Technology, Thuwal, Jeddah, K.S.A., 4 Banting and Best Department of Medical Research and 5 Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada Dr. von Hauner Children’s Hospital, Department of Pediatrics, University Hospital, Ludwig-Maximilians-Universität (LMU) Munich, 80337 Munich, Germany; Department of Food Science and Engineering, Jilin Agricultural University, Changchun, China Department of Anatomy and Cell Biology, University of Florida College of Medicine, Gainesville, FL, USA Department of Economics, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands; Economic Policy and Research Division, De Nederlandse Bank, Amsterdam, the Netherlands Department of Gastroenterology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, China. National Engineering Laboratory for Forest Tree Breeding Key Laboratory for Genetics and Breeding of Forest Trees and Ornamental Plants of Ministry of Education College of biological sciences and technology Beijing Forestry University Beijing 100083 China Department of Histology and Embryology Chongqing Medical University Chongqing P.R. China; Laboratory of Stem Cells and Tissue Engineering Chongqing Medical University Chongqing P.R. China School of Basic Medicine, Guizhou University of Traditional Chinese Medicine, Guiyang, China State Key Laboratory Breeding Base of Eco‐Environment and Bio‐Resource of the Three Gorges Area, Key Laboratory of Eco‐environments in Three Gorges Reservoir Region, Institute of Modern Biopharmaceuticals, Ministry of Education, School of Life Sciences Southwest University Chongqing China Department of Cardiology The First Affiliated Hospital of Harbin Medical University Harbin Heilongjiang Province China; Key Laboratory of Cardiac Diseases and Heart Failure of Harbin Medical University Harbin Heilongjiang Province China Department of Chemistry and University of Southern California, Los Angeles, California, USA. Department of Intensive Care Unit, General Hospital of Southern Theatre Command of PLA, Guangzhou, China; Key Laboratory of Hot Zone Trauma Care and Tissue Repair of PLA, General Hospital of Southern Theatre Command of PLA, Guangzhou, China College of Computer Science, Chongqing University, Chongqing 400044, China Max-Planck-Institut für Eisenforschung , Max-Planck-Str. 1, Düsseldorf 40237, Germany Beijing Key Laboratory of Bioelectromagnetism, Institute of Electrical Engineering, Chinese Academy of Sciences, Beijing 100190, China. Department of Public Health Sciences, Division of Health Policy and Outcomes Research, Rochester, NY College of Marine Life Sciences, Ocean University of China, Qingdao, P. R. China; 2 Department of Computer Science, Donnelly Center for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario, Canada Hepatobiliary Surgery Department and Unit of Organ Transplantation, First Hospital of China Medical University, Shenyang, Liaoning, P.R. China Heilongjiang Key Laboratory for Laboratory Animals and Comparative Medicine, College of Veterinary Medicine, Northeast Agricultural University, Harbin, China Department of Chemistry Graduate School of Science Kyoto University Kyoto 606-8502 Japan State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan Agricultural University, 650201 Kunming, China; National Engineering Research Center for Applied Technology of Agricultural Biodiversity, College of Plant Protection, Yunnan Agricultural University, 650201 Kunming, China College of Chemical Engineering; Sichuan University; Chengdu 610064, China Department of Chemistry, The Scripps Research Institute and UF Scripps Biomedical Research, University of Florida, Jupiter, FL 33458 Senior Project Officer, Department of Psychiatry, Asialink, The University of Melbourne, Carlton, VIC, and; Peking University Centre for Psychiatry Research and Training, the University of Melbourne, Carlton, VIC, Australia Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, China Department of Epidemiology and Biostatistics, Key Laboratory for Environment and Health, School of Public Health Tongji Medical College, Huazhong University of Sciences and Technology Wuhan China Department of Digestive Medicine, Peking Union Medical College Hospital Peking Union Medical College and Chinese Academy of Medical Sciences Beijing China Department of Chemistry, Capital Normal University, Beijing 100048, China Contribution from the Department of Chemistry, University of North Carolina, Chapel Hill, North Carolina 27599-3290 and Department of Chemistry, University of York, Heslington, York YO10 5DD, United Kingdom Department of Neurobiology, Institute of Neuroscience, Key Laboratory of Medical Neurobiology of the Ministry of Health of China, Collaborative Innovation Center for Brain Science, Zhejiang University School of Medicine, Hangzhou, China Tsinghua University Department of Clinical Laboratories, Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an Jiaotong University, Xi’an, China Center for Reproductive Medicine Shandong University Jinan China; National Research Center for Assisted Reproductive Technology and Reproductive Genetics Jinan China; The Key Laboratory of Reproductive Endocrinology (Shandong University), Ministry of Education Jinan China Center for Evidence-Based Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China. Department of Gastroenterology Zhejiang University Medical School, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University Hangzhou Zhejiang China China Academy of Engineering Physics Department of Chemistry, Graduate School of Science, Kyoto University, Kitashirakawa-oiwakecho, Sakyo-ku, Kyoto 606-8502, Japan The 2nd Medical College of Binzhou Medical University Yantai China; Department of Urology the Affiliated Yantai Yuhuangding Hospital of Qingdao University Yantai China Dalian Children's Hospital, Dalian, Liaoning 116012, China. Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan 48824, United States Department of Nephrology, Hongqi Hospital, Mudanjiang Medical University, Mudanjiang, People’s Republic of China College of Electronic Information and Automation, Tianjin University of Science and Technology 2 , Tianjin 300222, China Department of Ultrasound Medicine, Laboratory of Ultrasound Molecular Imaging, The Third Affiliated Hospital of Guangzhou Medical University, The Liwan Hospital of the Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China Beijing Key Laboratory of Learning and Cognition, School of Psychology, Capital Normal University Beijing China Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan 48824 Department of Public Health Sciences, University of Rochester School of Medicine and Dentistry, Rochester, New York. Department of Anesthesiology, Peking University Third Hospital, No. 49 North Garden Road, Haidian District, Beijing 100191, China Northwestern University, Applied Physics Program, 2145 Sheridan Road, Evanston, Illinois 60208, United States School of Biological Science and Technology, University of Jinan, Jinan, 250022, China Department of Dermatology Xinhua Hospital Shanghai Jiaotong University School of Medicine Shanghai China Department of Neurology and Neuroscience Center, The First Hospital of Jilin University, Changchun,China Key Laboratory of Physics and Technology for Advanced Batteries Ministry of Education College of Physics Jilin University Changchun 130012 PR China; College of Life Sciences Jilin University Changchun 130012 PR China Institute of Photoelectronic Thin Film Devices and Technology, Key Laboratory of Optoelectronic Thin Film Devices and Technology of Tianjin, College of Electronic Information and Optical Engineering, Engineering Research Center of Thin Film Photoelectronic Technology, Ministry of Education, Nankai University, Tianjin 300350, China; Shenzhen Research Institute of Nankai University, Shenzhen 518000, China Nebraska Center for Virology, University of Nebraska—Lincoln, Lincoln, Nebraska, USA; School of Biological Sciences, University of Nebraska—Lincoln, Lincoln, Nebraska, USA; College of Life Sciences, Nankai University, Tianjin, People's Republic of China College of Chemistry Key Laboratory of Advanced Energy Materials, Chemistry (Ministry of Education) Nankai University Tianjin 300071 P. R. China Laboratory of Cardiovascular Science, Gerontology Research Center, National Institute on Aging Intramural Research Program, National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA. Beijing Key Laboratory of Bioelectromagnetism, Institute of Electrical Engineering Chinese Academy of Sciences Beijing P.R. China From the Laboratory of Cardiovascular Science, Gerontology Research Center, National Institute on Aging, NIH, Baltimore, Md. Department of Infectious Diseases, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China; Key Laboratory of Microbial Technology and Bioinformatics of Zhejiang Province, Hangzhou, China; Regional Medical Center for National Institute of Respiratory Diseases, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat‐sen University Cancer Center Guangzhou China College of Food Science and Technology, Nanjing Agricultural University, Nanjing 210095, China Departments of Immunology and Etiology, Basic Medical College, Jiamusi University, Jiamusi, Heilongjiang 154007, P.R. China Core Facility of West China Hospital Sichuan University Chengdu 610041 China State Key Laboratory for Subtropical Forest Cultivation Co-constructed by Zhejiang Province and Ministry of Education,Zhejiang A&F University Lin'an 311300, China. College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu, Sichuan 610065, P. R. China Department of Ophthalmology, Henry Ford Health System, 1 Ford Place 5D, Detroit, MI 48202, USA Department of Public Health Sciences, University of Rochester, New York Department of Gastroenterology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, China; Institute of Gastroenterology, Zhejiang University (ZJU), Hangzhou 310016, China Department of Immunization Program, Hongkou District Center for Disease Control and Prevention, Shanghai, China State Key Laboratory of Applied Organic Chemistry, Key Laboratory of Advanced Catalysis of Gansu Province, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China Department of Gynecology Hospital of Heilongjiang Province, Nangang Branch Harbin China School of Life Sciences, Lanzhou University, Lanzhou 730000, China. liyue200906@163.com Key Laboratory for Green Organic Synthesis and Application of Hunan Province, Key Laboratory of Environmentally Friendly Chemistry and Application of Ministry of Education, College of Chemistry, Xiangtan University, Xiangtan 411105, China Department of Dermatology Xinhua Hospital affiliated to Shanghai Jiao Tong University School of Medicine Shanghai China; Institute of Dermatology Shanghai Jiao Tong University School of Medicine Shanghai China Department of Public Health Sciences, Division of Health Policy and Outcomes Research, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA Key Lab of Materials Physics Anhui Key Lab of Nanomaterials and Nanotechnology Institute of Solid State Physics Chinese Academy of Sciences Hefei 230031 P. R. China Department of Respiratory Medicine, Affiliated Hangzhou First People’s Hospital, Zhejiang University School of Medical, Hangzhou, Zhejiang, China Department of Ecology, College of Urban and Environmental Sciences, Peking University, Beijing 100871, China; From the Department of Cell Biology, SUNY Downstate Medical Center, Brooklyn, NY (Y.L., T.D., X.-C.J., Z.L.); Department of Biochemistry, School of Pharmacy, Fudan University, Shanghai, China (Y.L., J.D., T.D.); Molecular and Cellular Cardiology Program, VA New York Harbor Healthcare System, Brooklyn, NY (X.-C.J., Z.L.); Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN (M.-S.K.); and Jiangsu Hengrui Medicine, Shanghai, China (G.C.). University of Colorado Department of Ultrasound Medicine, Laboratory of Ultrasound Molecular Imaging, The Third Affiliated Hospital of Guangzhou Medical University, The Liwan Hospital of the Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, 510000, China State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China Department of Public Health Sciences University of Rochester School of Medicine and Dentistry Rochester NY The Affiliated Eye Hospital of Nanchang University, Nanchang, Jiangxi 330046, P.R. China Pharmaceutical Institute, Nanjing University of Chinese Medicine, Nanjing, China Department of Biochemistry and Molecular Biology, Michigan State University, 603 Wilson Road, East Lansing, MI 48824, U.S.A. Department of Otorhinolaryngology-Head & Neck Surgery，Xinhua Hospital，Shanghai Jiaotong University School of Medicine；Shanghai Jiaotong University School of Medicine Ear Institute；Shanghai Key Laboratory of Translational Medicine on Ear and Nose diseases，Shanghai，200092，China. International Center for Quantum Design of Functional Materials (ICQD), Hefei National Laboratory for Physical Science at the Microscale, and Synergetic Innovation Center of Quantum Information and Quantum Physics, University of Science and Technology of China, Hefei, Anhui 230026, China; Key Laboratory of Strongly-Coupled Quantum Matter Physics, Department of Physics, Chinese Academy of Sciences, University of Science and Technology of China, Hefei, Anhui 230026, China Department of Infectious Diseases, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine , Hangzhou, China; Key Laboratory of Microbial Technology and Bioinformatics of Zhejiang Province , Hangzhou, China; Regional Medical Center for National Institute of Respiratory Diseases, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine , Hangzhou, China Department of Ultrasound, Chinese People's Liberation Army General Hospital, Beijing 100853, China. liyue301@126.com dDepartment of Public Health Sciences, University of Rochester, Rochester, New York Department of Chemistry, University of Rochester, Rochester, New York 14627 Department of Hepatology, Division 3, Beijing Ditan Hospital, Capital Medical University and Teaching Hospital of Peking University, 8 Jingshundong Street, Beijing 100015, China Department of Gynaecology, The Second Hospital of Shandong University, Jinan, Shandong, China Department of Gastroenterology, The First Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (mainland) Sports Medicine Service, Beijing Jishuitan Hospital, Beijing, China. Institute of Medicinal Plant Development Chinese Academy of Medical Sciences Peking Union Medical College Beijing 100193 P. R. China; Key Laboratory of Bioactive Substances Resources Utilization of Chinese Herbal Medicine Ministry of Education Beijing 100193 P. R. China Department of Neurosurgery, West China Hospital Sichuan University Chengdu China Hepatobiliary Surgery Department, Second Affiliated Hospital of Chongqing Medical University, Chongqing, China Nebraska Center for Virology and School of Biological Sciences, University of Nebraska, Lincoln, NE 68583-0900; and Department of Cardiology, the First Affiliated Hospital of Harbin Medical University, Harbin, China Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702, and Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan 48824 College of Life Sciences, Xinjiang Agricultural University, Nongda East Road, Urumqi 830052, China Department of Anesthesiology Peking University Third Hospital Beijing China MOE Key Laboratory of Major Diseases in Children, National Key Discipline of Pediatrics (Capital Medical University), National Clinical Research Center for Respiratory Diseases, Beijing Key Laboratory of Pediatric Respiratory Infection Diseases, Beijing Pediatric Research Institute, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, China Department of Gastroenterology, Institute of Gastroenterology of Guangdong Province, Guangdong Provincial Key Laboratory of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, P. R. China Department of Ultrasound Medicine, Laboratory of Ultrasound Molecular Imaging, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China College of Resources and Environmental Sciences China Agricultural University Beijing China School of Chemistry and Material Science Shanxi Normal University Linfen Shanxi China State Key Laboratory of Metastable Materials Science and Technology, Hebei Key Laboratory of Nano-biotechnology, Yanshan University, Qinhuangdao 066004, P.R. China Department of Biochemistry and Molecular Biology Michigan State University East Lansing MI USA Jiangsu Collaborative Innovation Center for Photovoltaic Science and Engineering, Jiangsu Province Cultivation Base for State Key Laboratory of Photovoltaic Science and Technology, School of Materials Science and Engineering, Changzhou University, Changzhou 213164, China Key Laboratory of Materials Physics, Institute of Solid State Physics, Chinese Academia of Sciences, Hefei, 230031, P. R. China Department of Instrument Management & Analysis, Beijing Institute for Drug Control, Beijing 102206, China Department of Gastroenterology, Peking Union Medical College Hospital, Beijing 100730, China. Departments of Biochemistry and Molecular Genetics, The Ohio State University, Columbus, Ohio 43210

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