http://rdf.ncbi.nlm.nih.gov/pubchem/author/MD5_b6ec808753496c2502256e96570b2e54
Outgoing Links
Predicate | Object |
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family-name | Wei Yang Yang |
name | Wei Yang |
given-name | Wei |
organization-name | Department of Cardiothoracic Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330008, P.R. China Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiao Tong University, Xi'an, China. Departments of Molecular Biology (N.W., W.Y., E.W., A.G.) University Hospital Essen, 45122 Essen, Germany; Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892; Department of Hematology, Shengjing Hospital Affiliated to China Medical University, Shenyang 110022, Liaoning Province, China. E-mail: yangw@sj-hospital.org. Department of Medical Genetics & National Key Laboratory of Medical Molecular Biology, Peking Union Medical College, Beijing 100005, China. Institute of Chemical Materials, China Academy of Engineering Physics (CAEP), Mianyang 621900, P. R. China Department of Cardiology, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, China; and Department of Physiology II Kanazawa Medical University Uchinada Ishikawa 920‐0293 Japan; Department of Infectious Disease The Sheng Jing Hospital of China Medical University Shenyang 110009 China Sunrise Material Co., Ltd Jiangsu P. R. China Dongguan Maternal and Child Health Care Hospital Dongguan People's Republic of China Department of Thoracic Surgery, Beijing Chest Hospital, Capital Medical University, Beijing, China Department of Pulmonary and Critical Care Medicine, The First Hospital of China Medical University, Shenyang 110001, Liaoning, P.R. China; Department of Pulmonary and Critical Care Medicine, General Hospital of Northern Theatre Command, Shenyang 110001, Liaoning, P.R. China Institute of Coal Chemistry State Key Laboratory of Coal Conversion Chinese Academy of Sciences Taiyuan Shanxi 030001 P. R. China Eberhard Karls University Tübingen, Dept. of Traumatology, Schnarrenbergstr. 95, 72076 Tübingen, Germany; Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan 430030, PR China. Department of Medical Genetics and National Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Peking Union Medical College Chinese Academy of Medical Sciences, Beijing, PR China. State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116024, China; Chemical Analysis and Research Center, Dalian University of Technology, Dalian 116024, China State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Wuhan 430070, P. R. China School of Pharmacy, Hengyang Medical College, University of South China, 28 Western Changsheng Road, Hengyang, Hunan 421001, People's Republic of China Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA. Faculty of Food Science and Technology, Suzhou Polytechnic Institute of Agriculture, 279 Xiyuan Road, Suzhou 215008, P.R. China Abramson Cancer Center, Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania Departments of Chemistry and Biology, Center for Drug Design and Biotechnology, Georgia State University, Atlanta, Georgia 30303 CAS Key Laboratory of Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China Division of Neonatology and Developmental Medicine, Stanford University School of Medicine, Stanford, California Department of Critical Care Medicine, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, China. Department of Anesthesiology, Multidisciplinary Neuroprotection Laboratories, Duke University Medical Center, Durham, North Carolina, USA Key Laboratory of 3D Information Acquisition and Application of Ministry of Education, Capital Normal University, Beijing 100048, China. ywei26@sina.com Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China Department of Biostatistics, Epidemiology and Informatics University of Pennsylvania Perelman School of Medicine Philadelphia PA USA Clinical Center for Tumor Therapy, the Second Affiliated Hospital, Chongqing Medical University, Chongqing, China Stanford University Stanford College of Animal Science and Veterinary Medicine , Heilongjiang Bayi Agricultural University , Daqing High-tech Industrial Development Zone, Daqing 163319 , PR China Department of Cardiovascular Surgery; The Second Affiliated Hospital of Nanchang University; Nanchang; China Immunogenomics Precision Oncology Platform, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA Guangdong Key Laboratory of Animal Conservation and Resource Utilization, Guangdong Public Laboratory of Wild Animal Conservation and Utilization, Guangdong Institute of Applied Biological Resources, Guangzhou, Guangdong 510990, P.R. China The First Affiliated Hospital of Harbin Medical University, Harbin 150001, China. Stanford University, School of Medicine Stanford California Metabolomics and Analytics Centre, Leiden Academic Centre for Drug Research (LACDR) Leiden University Leiden the Netherlands Department of Laboratory, Shanghai Jiao Tong University Affiliated Shanghai Sixth People's Hospital, Shanghai 200233, P.R. China Hangzhou Hospital of Traditional Chinese Medicine, Hangzhou 310009, PR China Beijing National Laboratory for Condensed Matter Physics and Institute of Physics Chinese Academy of Sciences Beijing 100190 China University of Nevada, Reno, School of Community Health Sciences, United States Division of Neonatal and Developmental Medicine, Department of Pediatrics Stanford University School of Medicine Stanford California Department of Hand and Micro‐surgery the First Affiliated Hospital University of South China Hengyang Hunan China Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan 430074, Hubei P.R. China Key Laboratory of Molecular Mechanism and Intervention Research for Plateau Diseases of Tibet Autonomous Region, School of Medicine, XizangMinzu University, Xianyang, Shaanxi, 712082, China Department of Gynecology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China Department of Pathology, Stony Brook University, New York, NY, USA Key Laboratory of Drug Targeting and Drug Delivery System of Ministry of Education, West China School of Pharmacy, Sichuan University, Sichuan 610041, P.R. China Department of Pathophysiology, Basic Medical Science, Harbin Medical University, Harbin 150081, China Noyes Laboratory of Chemical Physics, 127-72, California Institute of Technology, Pasadena, CA 91125; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138; and Laboratoire de Chimie Biophysique, Institut de Science et Ingénierie Supramoléculaires, Université Louis Pasteur, 67000 Strasbourg France Department of Pediatrics Division of Neonatology and Developmental Medicine Stanford University School of Medicine Stanford California Department of Biophysics, Institute of Neuroscience, NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University School of Medicine, Hangzhou 310058, China. COSCO SHIPPING Technology CO., Ltd. Shanghai 200135 China Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062, P.R. China Jilin Provincial Key Laboratory on Molecular and Chemical Genetic The Second Hospital of Jilin University Changchun China Department of Pediatrics Stanford University School of Medicine California Department of Biochemistry and Molecular Genetics, Stem Cell Institute, University of Alabama at Birmingham, Birmingham, AL 35294; Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety Tongji Medical College, Huazhong University of Science and Technology Wuhan China; Department of Nutrition and Food Hygiene and MOE Key Lab of Environment and Health, School of Public Health Tongji Medical College, Huazhong University of Science and Technology Wuhan China Novartis Pharmaceuticals Corporation East Hanover New Jersey USA Center for Environmental Remote Sensing Chiba University Chibaken Japan McKusick-Zhang Center for Genetic Medicine, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing, China. Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA. Electronic address: wyang3@stanford.edu. Bioengineering College of Chongqing University, Chongqing, 400044, P.R.China. Key Laboratory of Medicinal Chemistry and Molecular Diagnosis (Ministry of Education), and Key Laboratory of Analytical Science and Technology of Hebei Province, College of Chemistry and Environment Science, Hebei University, Baoding 071002, China Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, People’s Republic of China College of Civil Engineering, Hunan University, Changsha, People’s Republic of China; Key Laboratory of Building Safety and Energy Efficiency of the Ministry of Education, Hunan University, Changsha, People’s Republic of China; National Center for International Research Collaboration in Building Safety and Environment, Hunan University, Changsha, People’s Republic of China Laboratory of Molecular Neurobiology, Multidisciplinary Neuroprotection Laboratories, Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina, USA Department of Urology, Third Affiliated Hospital, The Second Military Medical University, Shanghai 201805, P.R. China School of Radiological Medicine and Protection, Medical College of Soochow University, Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou, Jiangsu 215123, China State Key Laboratory of Chemical Oncogenomics, Peking University Shenzhen Graduate School, Shenzhen University Town, Xili, Shenzhen 518055, China Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia Department of Intensive Care Unit, Jingjiang People's Hospital Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Sheng 450000, China National Engineering Research Centre for Tissue Restoration and Reconstruction South China University of Technology Guangzhou 510006 China Department of Chemical Engineering, University of Washington, Box 351750, Seattle, Washington 98195; School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, PR China Department of Pharmacy, Lai’an County People’s Hospital, Chuzhou, Anhui 239200, China Department of Immunology, Basic college of Medical Sciences, Jilin University, Changchun City, Jilin Province, China. ywei@jlu.edu.cn. Center for Translational Medicine (W.Y., X.K., X.J., Z.Q., T.X., N.Q., D.F., W.P., Q.C., S.W.), the First Affiliated Hospital of Xi'an Jiaotong University School of Medicine, Xi'an, Shaanxi 710061, People's Republic of China; Suzhou Key Laboratory of Novel Semiconductor-Optoelectronics Materials and Devices, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China; Faculty of Food Science and Technology, Suzhou Polytechnic Institute of Agriculture, Suzhou 215008, China Division of Cancer Biology and Therapeutics, Departments of Surgery and Biomedical Sciences, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA. Department of Respiratory, General Hospital of Northern Theater Command, Shenyang, China Department of Clinical Laboratory, the First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China The University of Texas MD Anderson Cancer Center,Houston,TX,USA,77030 Material Transport & Transformation in Environmental & Life Processes Lab, The First Institute of Oceanography, SOA, Qingdao 266061, P. R. China, and The Key Laboratory of Analytical Sciences of MOE, Department of Chemistry, Xiamen University, Xiamen 361005, P. R.China College of Chemistry and Molecular Sciences Key Laboratory of Biomedical Polymers of Ministry of Education The Institute for Advanced Studies Hubei Province Key Laboratory of Allergy and Immunology Wuhan University Wuhan 430072 China Jiangsu Key Laboratory for Eco-Agricultural Biotechnology around Hongze Lake, Huaiyin Normal University, Huai'an 223300, China; Jiangsu Collaborative Innovation Center of Regional Modern Agriculture and Environmental Protection, Huaiyin Normal University, Huai'an 223300, China Department of TCM, Seventh People’s of Shanghai University of TCM, Shanghai 200137, China School of Materials Science and Engineering, Shaanxi University of Science & Technology, Xi’an 710021, China Key Laboratory of Ecological Forestry Engineering of Sichuan Province, College of Forestry, Sichuan Agricultural University, Chengdu, PR China Key Laboratory of Earth and Planetary Physics, Institute of Geology and Geophysics, Chinese Academy of Sciences, 100029 Beijing, China; Health and Family Planning Commission of Zhongjiang County Deyang City China State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany Chinese Academy of Sciences Kunming 650201 Yunnan China Department of Thoracic Surgery, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China March of Dimes, California Research Division, Oakland, California 94609, USA. WYang@marchofdimes.com Department of Pediatrics, Division of Neonatology Stanford University School of Medicine Stanford California Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania College of Chemistry and Molecular Sciences, Key Laboratory of Biomedical Polymers of Ministry of Education, Wuhan University, Wuhan 430072 Hubei, China Beijing Genomics Institute-Shenzhen, Shenzhen, China Multidisciplinary Neuroprotection Laboratories, Department of Anesthesiology Duke University Medical Center Durham North Carolina USA College of Chemistry and Molecular Sciences, Key Laboratory of Biomedical Polymers-Ministry of Education, Wuhan University, Wuhan 430072, Hubei, PR China College of Horticulture, South China Agricultural University, Guangzhou 510642, China Institute of Environment and Sustainable Development in Agriculture, Chinese Academy of Agricultural Sciences, Beijing, China Phase I Clinical Trial Laboratory, Affiliated Hospital to Changchun University of Chinese Medicine, Jilin, China School of Biomedical Engineering, Southern Medical University, Guangzhou 510000, China; Guangdong Provincial Key Laboratory of Medical Image Processing, Southern Medical University, Guangzhou 510000, China; Guangdong Province Engineering Laboratory for Medical Imaging and Diagnostic Technology, Southern Medical University, Guangzhou 510000, China; Guangdong-Hong Kong-Macao Greater Bay Area Center for Brain Science and Brain-Inspired Intelligence & Key Laboratory of Mental Health of the Ministry of Education, Southern Medical University, Guangzhou 510000, China Department of Pediatrics Stanford University School of Medicine Stanford California USA Department of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China Center for DMPK Research of Herbal Medicines, Institute of Chinese Materia Medica China Academy of Chinese Medical Sciences Beijing China Swedish Meteorological and Hydrological Institute (SMHI), 60176, Norrköping, Sweden State Key Laboratory of Crop Biology, College of Life Sciences, Shandong Agricultural University, Taian 271018, China Department of Gastrointestinal Surgery The First Affiliated Hospital of Chongqing Medical University Chongqing China Center for Clinical Epidemiology and Biostatistics and. The Affiliated Hospital of Changchun University of Chinese Medicine, Changchun 130021, China. Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China. University of Washington Department of Chemical Engineering, , Seattle, Washington 98195-1750 Medical Research Center, The Third People's Hospital of Chengdu, The Second Chengdu Hospital Affiliated to Chongqing Medical University, The Affiliated Hospital of Southwest Jiaotong University, Chengdu, Sichuan 610036, P.R. China Department of Breast Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA China‐Canada Joint Lab of Food Nutrition and Health (Beijing) Beijing Technology and Business University (BTBU) Beijing China; College of Basic Science Tianjin Agricultural University Tianjin China School of Community Health Sciences, University of Nevada, Reno, NV, USA Shensu Science & Technology Co. Ltd., Suzhou, China Laboratory Animal Center, China Medical University, Shenyang 110001, China Department of Nephrology, Liaoning Translational Medicine Center of Nephrology, The First Affiliated Hospital of Dalian Medical University, Dalian, China Department of Chemistry and Biochemistry, and ‡Institute of Molecular Biophysics, Florida State University, Tallahassee, Florida 32306, United States State Key Laboratory of Advanced Technology for Materials Synthesis and Processing; International School of Materials Science and Engineering; Wuhan University of Technology; Wuhan 430070; P. R. China Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School Center for Environmental Remote Sensing Chiba University Chiba Japan Department of Oncology, The Changzhi People's Hospital, Changzhi, Shanxi 046000, P.R. China Department of Anesthesiology Duke University Medical Center Durham North Carolina USA Faculty of Food Science and Technology; Suzhou Polytechnical Institute of Agriculture; Suzhou 215008; P. R. China Institute for Translational Medicine College of Medicine Qingdao University Qingdao 266021 P. R. China Contribution from the Department of Chemistry, Center for Drug Design and Advanced Biotechnology, Georgia State University, Atlanta, Georgia 30303 Department of Chemistry & Biochemistry Florida State University Tallahassee Florida 32306; Institute of Molecular Biophysics, Florida State University Tallahassee Florida 32306 Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China; Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, China Faculty of Food Science and Technology, Suzhou Polytechnic Institute of Agriculture, Suzhou 215008, People’s Republic of China 1National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College; 1Department of Nutrition and Food HygieneHubei Key Laboratory of Food Nutrition and Safety, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of China; 2MOE Key Lab of Environment and HealthSchool of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of China State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Sciences, Beijing 100012, China; Institute of Ecology, Chinese Research Academy of Environmental Sciences, Beijing 100012, China State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, P. R. China Institute of Aquatic Economic Animals and Guangdong Province Key Laboratory for Aquatic Economic Animals, School of Life Sciences, Sun Yat-Sen University, Guangzhou, P.R. China School of Biomedical Engineering, Sun Yat-sen University, Shenzhen 518107, China Beijing Tongren Hospital Affiliated to Capital Medical University, Beijing 100730, China. yangwei@trhos.com Engineering Laboratory for Functionalized Carbon Materials; Shenzhen Key Laboratory for Graphene-Based Materials; Graduate School at Shenzhen; Tsinghua University; Shenzhen 518055 Multidisciplinary Neuroprotection Laboratories, Departments of Anesthesiology, Biomedical Engineering, Neurobiology, and Neurosurgery, Duke University, Durham, NC. Department of Medical Oncology, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong 510000, P.R. China Institute of Cardiology, China Three Gorges University, Hubei Province, People's Republic of China. Department of Diagnostic Radiology, UT MD Anderson Cancer Center, Houston, TX, USA Department of Genetics, Washington University School of Medicine, St. Louis, United States Department of Chemistry, New York University, New York, New York 10003, and Laboratory of Molecular Biology, NIDDK, National Institutes of Health, 9000 Rockville Pike, Bldg 5, Rm B01-13, Bethesda, Maryland 20892 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, PR China Beijing Key Laboratory of Work Safety Intelligent Monitoring; School of Electronic Engineering; Beijing University of Posts and Telecommunications; Beijing; China Division of Medicinal & Natural Products Chemistry, College of Pharmacy and Center for Biocatalysis and Bioprocessing, University of Iowa, Iowa City, Iowa 52242 College of Resources and Environment Northeast Agricultural University Harbin China Florida State University School of Computational Science, , Tallahassee, Florida 32306-4120, USA, Department of Chemistry and Biochemistry, , Tallahassee, Florida 32306-4390, USA, and Institute of Molecular Biophysics, , Tallahassee, Florida 32306-4380, USA; Florida State University School of Computational Science, , Tallahassee, Florida 32306-4120, USA, Department of Chemistry and Biochemistry, , Tallahassee, Florida 32306-4390, USA, and Institute of Molecular Biophysics, , Tallahassee, Florida 32306-4380, USA; Florida State University School of Computational Science, , Tallahassee, Florida 32306-4120, USA, Department of Chemistry and Biochemistry, , Tallahassee, Florida 32306-4390, USA, and Institute of Molecular Biophysics, , Tallahassee, Florida 32306-4380, USA Department of Diagnostic Radiology University of Texas MD Anderson Cancer Center Houston TX The Center for Drug Research and Development Guangdong Pharmaceutical University Guangzhou Guangdong China Henan Key Laboratory of Polyoxometalate Chemistry, College of Chemistry and Chemical Engineering, Henan University, Kaifeng, Henan 475004, P. R. China The Center of Laboratory Medicine The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University Wenzhou China University of Nevada, Reno, USA Multidisciplinary Neuroprotection Laboratories Department of Anesthesiology Duke University Medical Center Durham NC USA Department of Geriatrics, Xuanwu Hospital, Capital Medical University, Beijing, China. Department of Hepatobiliary Surgery, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China Florida State University, Tallahassee, Florida, United States College of Animal Science and Technology, Jilin Agricultural University, Changchun 130118, Jilin, China Department of Engineering Mechanics, Zhejiang University, Hangzhou 310027, China.; Key Laboratory of Soft Machines and Smart Devices of Zhejiang Province, Zhejiang University, Hangzhou 310027, China.; Center for X-Mechanics, Department of Engineering Mechanics, Zhejiang University, Hangzhou 310027, China. Key Lab for Green Chemical Process (Ministry of Education), School of Chemistry and Environmental Engineering, Wuhan Institute of Technology, Wuhan 430205, P. R. China Department of Biophysics, and Department of Neurology of the Fourth Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310058, China; Liangzhu Laboratory, Zhejiang University Medical Center, Hangzhou, 311121, China; NHC and CAMS Key Laboratory of Medical Neurobiology, MOE Frontier Science Center for Brain Science and Brain-Machine Integration, School of Brain Science and Brain Medicine, Zhejiang University, 310058, China College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, Daqing, P.R. China. Contribution from the Department of Chemistry, State University at Stony Brook, Stony Brook, New York 11794-3400 Center for Translational MedicineFirst Affiliated Hospital of Xi'an Jiaotong University School of MedicineXi'anShaanxiPeople's Republic of China Institute of Pathogen Biology, Chinese Academy of Medical Sciences, Beijing, China 5 Shanghai Center for Mathematical Sciences, Fudan University, Shanghai, China Institute of Pharmacology & Toxicology, College of Pharmaceutical Sciences, Department of Pharmacology, Key Laboratory of Medical Neurobiology of The Ministry of Health of China, Zhejiang University, Hangzhou, China 1 State Key Laboratory of Plant Genomics, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences and 2Graduate University of Chinese Academy of Sciences, Beijing 100101, China; 1 State Key Laboratory of Plant Genomics, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences and 2Graduate University of Chinese Academy of Sciences, Beijing 100101, China College of Pharmacy China Pharmaceutical University Nanjing 210009 People's Republic of China Department of Materials Science, Fudan University, Shanghai, 200433, P.R. China Department of Radiation Oncology, Chinese PLA General Hospital, Beijing 100853, China College of Life Sciences, Peking University, Beijing 100871, China. zhaizh@plum.lsc.pku.edu.cn Faculty of Medicine, Department of Microbiology, Monash University, Melbourne, Victoria 3800, Australia Key Laboratory of Building Safety and Energy Efficiency of the Ministry of Education, Hunan University, Changsha 410082, China; National Center for International Research Collaboration in Building Safety and Environment, Hunan University, Changsha 410082, China; College of Civil Engineering, Hunan University, Changsha 410082, China Center for Perioperative Organ Protection Department of Anesthesiology Duke University Medical Center Durham NC Key Laboratory of Green Chemistry and Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, China Department of Pediatrics, Division of Neonatal and Developmental Medicine, Stanford University School of Medicine, Stanford, California National Animal Transmissible Spongiform Encephalopathy Laboratory State Key Laboratories for Agrobiotechnology Key Laboratory of Animal Epidemiology and Zoonosis College of Veterinary Medicine Ministry of Agriculture China Agricultural University Beijing 100193 China *Department of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL 35294; and University of Nevada, Reno, NV, USA Key Laboratory of Protein and Peptide Pharmaceuticals; Chinese Academy of Sciences–University of Tokyo Joint Laboratory of Structural Virology and Immunology, Institute of Biophysics Chinese Academy of Sciences Beijing China; University of the Chinese Academy of Sciences China Division of Life Science, Center for Cancer Research and State Key Lab for Molecular Neuroscience, Hong Kong University of Science and Technology, Hong Kong, China; Guangdong Lewwin Pharmaceutical Research Institute Co., Ltd, Hong Kong, China School of Computer Science and Information Technology, Northeast Normal University, Changchun 130117, China; College of Computer Science and Technology, Changchun Normal University, Changchun 130032, China Institute of Polymer Optoelectronic Materials and Devices, State Key Laboratory of Luminescent Materials and Devices, South China University of Technology, Guangzhou 510640, P. R. China Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China Jilin Provincial Key Laboratory on Molecular and Chemical Genetic, The Second Hospital of Jilin University, 218 Ziqiang Street, Changchun 130041, China Department of Chemistry, Southern University of Science and Technology, Shenzhen 518055, China State Key Laboratory of Fine Chemicals; Dalian University of Technology; China Department of Critical Care Medicine, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, China Hepatobiliary Institute, Southwest Hospital, Third Military Medical University, No. 30 Gaotan Yan, ShapingBa District, Chongqing, 400038, China. School of Biomedical Engineering, Southern Medical University, Guangzhou 510515, China 4Key Laboratory of Transgenic Animal Research, Laboratory Animal Center of Liaoning Province, China Medical University, Shenyang, China Department of Physiology, Medical School of Xi'an Jiaotong University, Xi'an Shannxi, China. School of Laboratory Medicine and Life Science Wenzhou Medical University Wenzhou Zhejiang China; Key Laboratory of Laboratory Medicine, Ministry of Education Wenzhou Medical University Wenzhou Zhejiang China Department of Pharmacology Cardiovascular Research Centre and the Alberta Diabetes Institute Li Ka Shing Research Centre University of Alberta Edmonton AB Canada Department of Soil and Water sciences, College of Resources and Environmental Sciences China Agricultural University Beijing China Harbin Medical University Cancer Hospital, Harbin, China Key Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, China Florida State University Department of Chemistry and Biochemistry, , Tallahassee, Florida 32306, USA; Institute of Molecular Biophysics, , Tallahassee, Florida 32306, USA; and School of Computational Science, , Tallahassee, Florida 32306, USA; Florida State University Department of Chemistry and Biochemistry, , Tallahassee, Florida 32306, USA; Institute of Molecular Biophysics, , Tallahassee, Florida 32306, USA; and School of Computational Science, , Tallahassee, Florida 32306, USA; Florida State University Department of Chemistry and Biochemistry, , Tallahassee, Florida 32306, USA; Institute of Molecular Biophysics, , Tallahassee, Florida 32306, USA; and School of Computational Science, , Tallahassee, Florida 32306, USA Department of Urology College of Chemistry, Dalian University of Technology, Dalian 116023, P. R. China College of Chemistry and Molecular Sciences; Key Laboratory of Biomedical Polymers of Ministry of Education; The Institute for Advanced Studies; Wuhan University; Hubei Province Key Laboratory of Allergy and Immunology Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892 State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China 15Department of Anesthesiology, Duke University, Durham, North Carolina. Department of Critical Care Medicine, The First Affiliated Hospital of Harbin Medical University, 23 Youzheng Street, Harbin 150001, P.R. China Laboratory of Molecular Neurobiology, Multidisciplinary Neuroprotection Laboratories, Department of Anesthesiology, Duke University Medical Center, Durham, NC, USA Zhejiang Provincial Tongde Hospital, Zhejiang Province Academy of Chinese Medicine and Pharmacy, Hangzhou 310007, China. td-feiyang@163.com Cancer Hospital of Shantou University Medical College, Guangdong Province, People’s Republic of China Department of Anorectal, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China. yangweiyishi@163.com. School of Basic Medical Sciences; Zhejiang University; Hangzhou; China College of Polymer Science and Engineering Sichuan University Chengdu 610017 China Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland at Baltimore, Baltimore, Maryland 21201, United States Tianmu Lake Institute of Advanced Energy Storage Technologies; Chuangzhi Park; Zhongguancun; Liyang; China Department of Hepatobiliary Surgery, First Affiliated Hospital, Medical School of Xi’an Jiaotong University, Xi’an 710061, China Department of Chemistry State Key Laboratory of Water Environment Simulation School of Environment Beijing Normal University Beijing 100875 China Bloodworks Research Institute, Seattle, WA;; NanoString Technologies, Seattle, WA; Department of Chemistry; East China Normal University; Shanghai 200062; P. R. China National R&D Center for Citrus Preservation, Key Laboratory of Horticultural Plant Biology, Ministry of Education, Huazhong Agricultural University, Wuhan, P.R. China Department of Chemistry, University of Georgia, Athens, Georgia 30602, United States Department of Biochemistry, UMDNJ−Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, New Jersey 08854 Email: 13681408183@163.com. Department of Chemistry, University of Florida, Gainesville, Florida 32611 and Institute of Molecular Biophysics, Florida State University, Tallahassee, Florida 32306 Department of Gastroenterology, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, Hubei Province 441021, China Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Ultrasound, Peking University Cancer Hospital & Institute, Haidian District, Beijing 100142, China Department of Oncology, The Affiliated Hospital of Southwest Medical University, Luzhou, 646000, China; Institute of Rocket Force Medicine, State Key Laboratory of Trauma and Chemical Poisoning, Third Military Medical University (Army Medical University), Chongqing, 400038, China Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Ultrasound Peking University Cancer Hospital and Institute Beijing China Institute of Rocket Force Medicine, State Key Laboratory of Trauma, Burns and Combined Injury, Third Military Medical University (Army Medical University), Chongqing, China The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China. Department of Radiobiology, School of Radiological Medicine and Protection, Medical College of Soochow University, Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou, Jiangsu, China Chinese PLA General Hospital; Department of Endocrinology; 28 Fuxing Road Haidian district Beijing Beijing China 100853 Department of Anesthesiology, West China Hospital, Sichuan University and The Research Units of West China (2018RU012), Chinese Academy of Medical Sciences, Chengdu, China; Department of Anesthesiology and Translational Neuroscience Center, Laboratory of Anesthesia and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, China. Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1HH, England, UK 2 Department of Respiratory Diseases, Third Clinical Hospital, Beijing University, Beijing 100083, China State Key Laboratory of Earth Surface Processes and Resource Ecology, Beijing Normal University, Beijing 100875, China. yangwei1982@ires.cn State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences Beijing 100101, People’s Republic of China Department of Molecular Sciences, Infection Discovery, AstraZeneca R&D Boston, Waltham, Massachusetts 02451 State Key Laboratory of Drug Research, CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, P. R. China Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China. yangyxq@ruc.edu.cn 1 Departments of Human Genetics Key Laboratory for Renewable Energy, Beijing Key Laboratory for New Energy Materials and Devices, Beijing National Laboratory for Condensed Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing 100190, China Guangdong Key Laboratory of Animal Conservation and Resource Utilization, Guangdong Public Laboratory Wild Animal Conservation and Utilization, Guangdong Institute of Applied Biological Resources, Guangzhou, China ywdoccn@163.com. School of Integrated Circuit Science and Engineering Beihang University Beijing 100191 P. R. China Professor, School of Community Health Sciences, University of Nevada-Reno, Reno, NV Department of Engineering Mechanics, and Soft Matter Research Center (SMRC); Zhejiang University; Hangzhou 310027, China Department of Chemistry, Center for Drug Design and Advanced Biotechnology, Georgia State University, Atlanta, Georgia 30303, Department of Biology, Georgia State University, Atlanta, Georgia 30303, Department of Biomedical Engineering, Emory University, Atlanta, Georgia 30333, Department of Radiology, Emory University, Atlanta, Georgia 30333, and Department of Geosciences, Georgia State University, Atlanta, Georgia 30303 Ministry of Education (MOE) International Joint Laboratory of Materials Microstructure, Institute for New Energy Materials and Low Carbon Technologies, School of Materials Science and Engineering, Tianjin University of Technology, Tianjin 300384, China Key Laboratory of Medical Neurobiology, Department of Neurobiology, Collaborative Innovation Center for Brain Science, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China. *Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892; Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine at the University of Pennsylvania, PA, USA 3Departments of Surgery and Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California. Shantou University Medical College Shantou China Infection and Immunity Program, Department of Microbiology, Biomedicine Discovery Institute Monash University Clayton VIC 3800 Australia Department of Paediatric Neurosurgery Beijing Children's Hospital National Centre for Children's Health Capital Medical University Beijing China Department of Clinical Laboratory, Zhejiang Provincial People's Hospital, Hangzhou Medical College, 310014 Hangzhou, China Department of Hepatobiliary Surgery, The First Affiliated Hospital, Xioan Jiaotong University, Xioan, Shaanxi, 710061, P. R. China. joneso297@sina.com Department of Clinical Laboratory, Key laboratory of Carcinogenesis and Translational Research (Ministry of Education), Beijing, PR China Department of Orthopaedics, Sir Run Run Shaw Hospital, School of Medicine Zhejiang University Hangzhou Zhejiang China Department of Ophthalmology, Hannan District People's Hospital, Wuhan, Hubei 430090, P.R. China From the Division of Cardiology, Department of Pediatrics, The Children’s Hospital of Philadelphia (L.M.-R., S.M.P., M.A.F., J.R., E.G.), Department of Clinical Sciences, Temple Clinical Research Center, Temple University School of Medicine (H.Z.), Department of Biostatistics and Epidemiology (X.Z., J.S.), and Department of Biostatistics and Epidemiology, Center for Clinical Epidemiology and Biostatistics (W.Y.), Perelman School of Medicine, University of Pennsylvania , Philadelphia, PA; and... School of Life Sciences; Tsinghua University; Beijing 100084; P. R. China College of Chemistry, Chemical Engineering and Materials Science, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Shandong Normal University, Jinan 250014, China; College of Chemical Engineering, Northeast Electric Power University, Jilin 132012, China State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, School of Materials Science and Engineering, Wuhan University of Technology, Wuhan 430070, Hubei, People’s Republic of China Leibniz Institute for Solid State and Materials Research Helmholtzstraße 20 01069 Dresden Germany Shenzhen Institute of Guangdong Ocean University, Shenzhen 518108, China; Guangzhou Institute of Energy Conversion, Chinese Academy of Sciences, CAS Key Laboratory of Renewable Energy, Guangdong Key Laboratory of New and Renewable Energy Research and Development, Guangzhou 510640, China; School of Mechanical and Power Engineering, Guangdong Ocean University, Zhanjiang 524000, China Institute of Pharmaceutical Biotechnology and Engineering College of Biological Science and Engineering Fuzhou University Fuzhou Fujian 350002 China State Key Laboratory of High Performance Ceramics and Superfine Microstructures Shanghai Institute of Ceramics Chinese Academy of Sciences Shanghai 200050 P. R. China; Shanghai Key Laboratory of Green Chemistry and Chemical Processes School of Chemistry and Molecular Engineering East China Normal University Shanghai 200062 P. R. China Laboratory of Advanced Optoelectronic Materials, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, Jiangsu 215123, P.R. China Institute of Animal Nutrition Northeast Agricultural University Harbin China Department of Chemical Engineering, University of Washington, Seattle, Washington 98195, and Institute of Photonics and Electronics of the Academy of Sciences of the Czech Republic, 182 51 Prague, Czech Republic Oncology Department of Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai TCM University, Shanghai, People's Republic of China Washington University School of Medicine Infection and Immunity Program, Biomedicine Discovery Institute and Department of Microbiology, Monash University, Clayton Campus, Clayton, VIC 3800, Australia Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia Fujian Key Laboratory of Functional Marine Sensing Materials, College of Materials and Chemical Engineering, Minjiang University, Fuzhou, Fujian 350108, People’s Republic of China Jiangsu Key Laboratory for Biodiversity and Biotechnology College of Life Sciences Nanjing Normal University Nanjing China Research Institute of Natural Gas Technology, PetroChina Southwest Oil & Gasfield Company, Chengdu 610213, PR China State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China. College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, China Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology; Ministry of Education Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology Graduate Program in Biochemistry, ‡Department of Biology, and §Department of Chemistry, Brandeis University, 415 South St., MS 009, Waltham, Massachusetts 02454, United States; Institute of Molecular Biophysics and ⊥Department of Chemistry and Biochemistry, Florida State University, Tallahassee, Florida 32306, United States Department of Orthopedics, People's Hospital of Rongchang District, Chongqing, China Center for Pharmacoepidemiology Research and Training, Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania USA; Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania USA Department of Ophthalmology, The First Hospital of Jilin University, Changchun, Jilin, China (mainland) Shandong Provincial Key Laboratory of Chemical Energy Storage and Novel Cell Technology; School of Chemical and Chemical Engineering; Liaocheng University; 252059 Liaocheng; P.R. China Beijing Key Laboratory of Epilepsy Beijing China; Center of Epilepsy, Beijing Institute for Brain Disorders Beijing China Department of Anesthesiology and Critical Care Medicine Johns Hopkins University School of Medicine Baltimore MD; Department of Cardiovascular Medicine Xiangya Hospital, Central South University Changsha China Department of Physiology II, Kanazawa Medical University, Uchinada, Japan; Department of Infectious Disease, The Sheng Jing Hospital of China Medical University, Shenyang, China State Key Laboratory of Advanced Power Transmission Technology, State Grid Smart Grid Research Institute Co. Ltd, Beijing, 102209, China California Research Division, March of Dimes Foundation, Oakland, California Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania From the Department of Integrative Medicine and Neurobiology, Institutes of Integrative Medicine, School of Basic Medical Science, Fudan University, Shanghai, China; Institutes of Brain Science, Brain Science Collaborative Innovation Center, State Key Laboratory of Medical Neurobiology, Shanghai Medical College, Fudan University, Shanghai, China. Department of Psychology, Changchun Sixth Hospital, Changchun, Jilin 130033, P.R. China Infection Discovery, AstraZeneca R&D Boston, Waltham, Massachusetts 02451 Department of Neurobiology, College of Medicine, Zhejiang University, Hangzhou 310006, China. Department of Clinical Laboratory, Zhejiang Provincial People’s Hospital, Hangzhou Medical College, Hangzhou, PR China; State Key Laboratory of Advanced Technology for Materials Synthesis and Processing International School of Materials Science and Engineering Wuhan University of Technology Hubei Wuhan 430070 P. R. China Guangzhou General Pharmaceutical Research Industry, Guangzhou, China. Department of Immunology, College of Basic Medical Sciences, Jilin University, Changchun, Jilin, China; Clinical Center for Tumor Therapy of the Second Affiliated Hospital of Chongqing Medical University, Chongqing, China; College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, Daqing 163319, Heilongjiang, China From the Department of Critical Care Medicine, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China. College of Chemistry and Molecular Sciences; Key Laboratory of Biomedical Polymers of Ministry of Education; The Institute for Advanced Studies; Hubei Province Key Laboratory of Allergy and Immunology; Wuhan University Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, Philadelphia, PA. School of Safety Science and Engineering, Anhui University of Science and Technology, Huainan 232001, P. R. China Key Laboratory of Molecular Mechanism and Intervention Research for Plateau Diseases of Tibet Autonomous Region School of Medicine Xizang Minzu University Xianyang China; Department of Emergency the Affiliated Hospital of Xizang Minzu University Xianyang China Department of Laboratory Diagnostics First Affiliated Hospital of Harbin Medical University Harbin Heilongjiang 150001 China School of Health Economics and Management, Nanjing University of Chinese Medicine, Nanjing, China College of Polymer Science and Engineering State Key Laboratory of Polymer Materials Engineering Sichuan University Chengdu Sichuan 610065 China School of Environmental Science and Engineering, Huazhong University of Science and Technology, Wuhan 430074, P. R. China Department of Diagnostic Radiology, University of Texas MD Anderson Cancer Center, Houston, Texas. College of Basic Science, Tianjin Agricultural University, Tianjin 300392, China Department of Biostatistics, Epidemiology and Informatics and; Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; Institute of Polymer Optoelectronic Materials and Devices, State Key Laboratory of Luminescent Materials and Devices, South China University of Technology, Guangzhou 510640, China Institute for Translational Medicine The Affiliated Hospital of Qingdao University College of Medicine Qingdao University Qingdao Shandong 266021 P. R. China; School of Basic Medicine College of Medicine Qingdao University Qingdao Shandong 266071 P. R. China College of Animal Science And Veterinary Medicine, Heilongjiang Bayi Agricultural University, China. State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of Technology Wuhan Hubei 430070 P. R. China Department of Interventional Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China Department of Chemistry & Biochemistry, Florida State University, Tallahassee, Florida 32306, United States; Institute of Mol Biophysics, Florida State University, Tallahassee, Florida 32306, United States Stanford University Stanford California College of Chemistry; Chemical Engineering and Materials Science; Soochow University; Suzhou; P.R. China Department of Physiology, San Francisco State College, San Francisco, California Institute of Applied Physics and Computational Mathematics 1 LCP, , P.O. Box 8009, Beijing 100088, People's Republic of China Affiliated Cancer Hospital of Zhengzhou University, Department of Pharmacy, Zhengzhou 450000, China College of Polymer Science and Engineering, Sichuan University, State Key Laboratory of Polymer Materials Engineering, Chengdu, 610065, Sichuan, China Department of Medical Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center, Guangzhou, People's Republic of China Transplantation Research Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston MA; Department of Diagnostic Radiology, University of Texas M.D. Anderson Cancer Center, Houston, TX, USA Department of Respiratory Disease, Peking University Third Hospital, Beijing 100191, China. Department of Radiology, Jinshan Hospital Fudan University Shanghai P.R. China; Department of Radiology General Hospital of Ningxia Medical University Yinchuan P.R. China Department of Ophthalmology, the Affiliated Hospital of Southwest Medical University, Luzhou, P.R. China Center for Perioperative Organ Protection, Department of Anesthesiology, Duke University Medical Center, Durham, NC, USA Wuhan Center for Adolescent Poor Vision Prevention and Control, Wuhan, Hubei, PR China Key Laboratory of Earth and Planetary Physics, Institute of Geology and Geophysics, Chinese Academy of Sciences, Beijing 100029, China; Department of Physics, Taizhou University, Taizhou 318000, China Food Chemistry and Food Development, Department of Biochemistry, University of Turku, FI-20014, Turku, Finland Department of Endocrinology, Jiading District Central Hospital Affiliated Shanghai University of Medicine & Health Sciences, Shanghai, China Department of Pediatrics, Stanford University, Stanford, California, USA School of Public Health, University of Nevada, Reno, Reno, NV, United States Department of Radiobiology, School of Radiological Medicine and Protection, Medical College of Soochow University, Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou, Jiangsu 215123, China Department of Geriatrics, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, China Department of Pediatrics, The People’s Hospital of Shenzhen Baoan District, Shenzhen, China Department of Genetics, Washington University School of Medicine, St. Louis, MO; Center for Translational Medicine, The First Affiliated Hospital of Xi’an Jiaotong University School of Medicine, Xi’an, Shaanxi, People’s Republic of China Department of Pharmaceutical Sciences; University of Maryland School of Pharmacy; Baltimore; United States Department of Anorectal Surgery, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine; Anorectal Disease Institute of Shuguang Hospital The CBR Institute for Biomedical Research and Departments of Pathology, Anesthesia, and Pediatrics, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115 Department of Chemistry and Biochemistry, Florida State University, 95 Chieftan Way, Tallahassee, Florida 32306-4390, United States; Institute of Molecular Biophysics, Florida State University, Kasha Laboratory, Tallahassee, Florida 32306-4390, United States Department of Clinical Laboratory, Zhejiang Provincial People’s Hospital, Hangzhou Medical College, Hangzhou, China; Department of Urology Xinhua Hospital School of Medicine Shanghai Jiaotong University 1665 Kongjiang Road Shanghai 200092 P. R. China Division of Systems Biomedicine and Pharmacology, Leiden Academic Center for Drug Research (LACDR), Leiden University, EZ Leiden, The Netherlands Department of Orthopedics, Xijing Hospital, Fourth Military Medical University, Xi’an, Shaanxi 710032, People’s Republic of China Department of Basic Medicine, Shantou University Medical College, Shantou 515041, China Radiology, The University of Texas MD Anderson Cancer Center, Houston, Tex. Karolinska Institutet 1 Department of Cell and Molecular Biology , , 171 77, Stockholm , Sweden; Karolinska Institutet 1 Department of Cell and Molecular Biology , , 171 77, Stockholm , Sweden University of Texas MD Anderson Cancer Center, Department of Diagnostic Radiology, Houston, Texas Department of Neurosurgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, P.R. China Key Laboratory of Biomedical Polymers of Ministry of Education, College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, China Department of Biochemistry, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061-0308 Florida State University 1 Institute of Molecular Biophysics, , Tallahassee, Florida 32306, USA; Florida State University 2 Department of Chemistry and Biochemistry, , Tallahassee, Florida 32306, USA; Nankai University 3 College of Life Sciences, , Tianjin 300071, People’s Republic of China State Key Laboratory of Marine Environmental Science and College of Ocean and Earth Sciences, Xiamen University, Xiamen 361102, China Center for DMPK Research of Herbal Medicines, Institute of Chinese Materia Medica, China Academy of Chinese, Beijing 100700, China Jilin Provincial Key Laboratory on Molecular and Chemical Genetics The Second Hospital of Jilin University Changchun China Department of Molecular and Systems Biology Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth Lebanon New Hampshire USA State Key Laboratory of Fine Chemicals, Liaoning Key Laboratory of Clean Utilization of Chemical Resources, Institute of Chemical Engineering, Dalian University of Technology, Dalian 116024, P. R. China Institute of Rocket Force Medicine , State Key Laboratory of Trauma, Burns and Combined Injury, , 400038, Chongqing, China; Third Military Medical University (Army Medical University) , State Key Laboratory of Trauma, Burns and Combined Injury, , 400038, Chongqing, China Jiangsu Key Laboratory for Biodiversity and Biotechnology College of Life Sciences Nanjing Normal University China Department of Gastroenterology, the First Hospital of Lanzhou University, Lanzhou Gansu Province, China Department of Cardiology The Fourth Affiliated Hospital of Harbin Medical University Harbin China Department of Chemistry; Southern University of Science and Technology; Shenzhen; China State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Provincial Key Laboratory of Pharmaceutics, Guizhou Medical University, Guiyang, China; Teaching and Research Section of Natural Medicinal Chemistry, School of Pharmacy, Guizhou Medical University, Guiyang, China Department of Neurobiology, Zhejiang University School of Medicine, Hangzhou, China. 1Department of Molecular & Systems Biology, Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire. College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University , Daqing163319, Heilongjiang , China Food Chemistry and Food Development, Department of Biochemistry, and ‡Kevo Subarctic Research Institute, University of Turku, FI-20014 Turku, Finland Department of Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA. School of Public Health, University of Nevada, Reno, Nevada, USA 1Department of Anesthesiology, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, China; 2Laboratory of Mitochondria and Metabolism, National-Local Joint Engineering Research Centre of Translational Medicine of Anesthesiology, West China Hospital, Sichuan University, Chengdu, China Department of Ophthalmology, First Affiliated Hospital, Jilin University, Changchun 130021, China. Department of Diagnostic Radiology, The University of Texas M. D. Anderson Cancer Center, Unit 1350, 1515 Holcombe Blvd, Houston, TX 77030. Key Laboratory of Tibetan Environment Changes and Land Surface Processes, Institute of Tibetan Plateau Research, Chinese Academy of Sciences, Beijing 100085, China; From the Shantou University Medical College, China (G.Z., W.Y., J.W., B.C., X.Y., S.Y.) Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania Shanxi Key Laboratory of Ecological Animal Science and Environmental Veterinary Medicine, College of Veterinary Medicine Shanxi Agricultural University Taigu People's Republic of China Department of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515, China; Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China Department of Hematology Shengjing Hospital of China Medical University Shenyang China Department of Oral and Maxillofacial Surgery, The Second Hospital of Hebei Medical University, Hebei, China Department of Immunology, College of Basic Medical Sciences, Jilin University, Changchun, China Tianjin Agricultural University Tianjin China Center for Clinical Epidemiology & Biostatistics, University of Pennsylvania 3 , Philadelphia, Pennsylvania , USA Department of Pediatrics Stanford University Department of Pharmacy, Huangpu Hospital of The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510700, China. Department of Surgical Oncology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health (NCCH), Beijing 100045, P.R. China Department of Surgery Oncology, Beijing Children’s Hospital, Capital Medical University, Beijing, PR China Department of Nutrition and Food Hygiene, School of Public Health Departments of Medicine and Epidemiology and Biostatistics, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania; Department of Breast Imaging, The University of Texas MD Anderson Cancer Center, Houston Division of Diabetes, Endocrinology and Metabolism, Department of Metabolism, Digestion and Reproduction Imperial College London London UK Department of Medical Laboratory Dayi County People's Hospital Chengdu Sichuan Province China Department of Infectious Diseases and Microbiology, University of Pittsburgh, Pittsburgh, Pennsylvania Department of Pulmonary and Critical Care Medicine, General Hospital of Northern Theatre Command, Shenyang, Liaoning 110001, P.R. China Department of Imaging Binzhou Medical University Yantai China Department of Internal Medicine, University of California, Davis, Sacramento, California.; Division of Endocrinology, University of California, Davis, Sacramento, California. Leibniz Institute of Photonic Technology Jena Jena Germany Clinical Veterinary Medicine, College of Animal Science and Veterinary Medicine Heilongjiang Bayi Agricultural University Daqing China CAS Key Laboratory of Microbial Physiological and Metabolic Engineering, State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China Biomedicine Discovery Institute Department of Microbiology Monash University Melbourne Vic. Australia School of Environmental Science and Engineering, Tianjin University, Tianjin 300072, China; Tianjin Eco-City Environmental Protection Co. Ltd, Tianjin 300467, China State Key Laboratory of Advanced Power Transmission Technology; State Grid Global Energy Interconnection Research Institute; Beijing 102211; China Department of Oncology, Changzhi Peopleˊs Hospital, Changzhi, Shanxi, China Ministry of Health Key Laboratory of Systems Biology of PathogensInstitute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Faculty of Chemistry, Sichuan University, Chengdu 610064, People’s Republic of China KingMed Diagnostics and KingMed School of Laboratory Medicine Guangzhou Medical University Guangzhou China Veterans Affairs Medical Center, Nashville, Tennessee 37212-2637, and Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37212-2175 Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University), Ministry of Education, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, China Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA Department of Anesthesiology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong 510080, P.R. China Ningxia Integrated Traditional Chinese and Western Medicine Hospital Yinchuan China Key Laboratory for Biotech-Drugs of National Health Commission, Key Laboratory for Rare & Uncommon Diseases of Shandong Province, Biomedical Sciences College & Shandong Medicinal Biotechnology Centre, Shandong First Medical University & Shandong Academy of Medical Sciences, Ji'nan, China. Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892; and State Key Laboratory of Electroanalytical Chemistry Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 P. R. China Laboratory of Advanced Optoelectronic Materials; College of Chemistry; Chemical Engineering and Materials Science; Soochow University; Suzhou Department of Critical Care Medicine, The First Affiliated Hospital of Harbin Medical University, Harbin, 150001 Heilongjiang Province, China Department of Neurobiology Zhejiang University School of Medicine Hangzhou Zhejiang China Department of Bacteriology, Guangxi Veterinary Research Institute, Nanning, Guangxi, China; Guangxi Key Laboratory of Animal Vaccines and Diagnostics, Nanning, Guangxi, China Nuclear Medicine Global Energy Interconnection Research Institute; State Key Laboratory of Advanced Power Transmission Technology; Beijing 102211; P. R. China Department of Chemistry & Biochemistry, Florida State University, Tallahassee, Florida 32306; Institute of Molecular Biophysics, Florida State University, Tallahassee, Florida 32306 Department of Materials Physics; School of Science; Xi'an University of Posts and Telecommunications; Xi'an 710121; China Phase I Clinical Trial Laboratory, Affiliated Hospital of Changchun University of Chinese Medicine, Changchun, China Department of Nutrition and Food Hygiene School of Public Health Tongji Medical College Huazhong University of Science and Technology Wuhan China; Hubei Key Laboratory of Food Nutrition and Safety School of Public Health Tongji Medical College Huazhong University of Science and Technology Wuhan China; Ministry of Education Key Laboratory of Environment School of Public Health Tongji Medical College Huazhong University of Science and Technology Wuhan China Phase I Clinical Trial Laboratory, Affiliated Hospital to Changchun University of Chinese Medicine, Changchun, China Institute of Applied Physics and Computational Mathematics *CBR Institute for Biomedical Research and; **Pathology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115; Institute for Translational Medicine, The Affiliated Hospital of Qingdao University, Qingdao Medical College, Qingdao University, Qingdao 266021, Shandong, P. R. China; School of Basic Medicine, College of Medicine, Qingdao University, Qingdao 266071, Shandong, P. R. China Department of Respiratory Medicine, Putuo Hospital, Shanghai University of Traditional Chinese Medicine Department of Pediatrics, Division of Neonatal and Developmental Medicine Stanford University School of Medicine Stanford California Department of Biochemistry, University of Washington, Seattle, WA 98105, USA.; Institute for Protein Design, University of Washington, Seattle, WA 98105, USA. University of Science and Technology of China; Anhui Institute of Optics and Fine Mechanics Cancer Hospital of Shantou University Medical College, Shantou, Guangdong Province, People’s Republic of China Department of Engineering Mechanics, Zhejiang University, Hangzhou, China.; Key Laboratory of Soft Machines and Smart Devices of Zhejiang Province, Hangzhou, China.; Center for X-Mechanics, Zhejiang University, Hangzhou, China. Florida State University 1 School of Computational Science, , Tallahassee, Florida 32306, USA; Florida State University 2 Department of Chemistry and Biochemistry, , Tallahassee, Florida 32306, USA; Florida State University 3 Institute of Molecular Biophysics, , Tallahassee, Florida 32306, USA Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing) Department of Ultrasound, Peking University Cancer Hospital and Institute Beijing China Department of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China. yanglab@smu.edu.cn. Urological Diseases Research Center, Department of Urology, Children's Hospital Boston, Boston, MA;; Department of Surgery, Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA;; Proteomics Center, Children's Hospital Boston, Boston, MA; and School of Energy and Power Engineering, Jiangsu University, Zhenjiang, Jiangsu, People’s Republic of China State Key Laboratory of Medical Molecular Biology,Department of Biochemistry and Molecular Biology,Institute of Basic Medical Sciences,CAMS and PUMC,Beijing 100005,China. Tencent AI Lab, Shenzhen, China Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia GeneMind Biosciences Company Limited , Shenzhen 518001 , China School of Biomedical Engineering Southern Medical University Guangzhou China; Guangdong Provincial Key Laboratory of Medical Image Processing Southern Medical University Guangzhou China Division of Neonatal and Developmental Medicine, Department of Pediatrics Stanford University School of Medicine Stanford California USA Shengjing Hospital Affiliated to China Medical University, Shenyang, China Department of Diagnostic Radiology, Breast Imaging, The University of Texas MD Anderson Cancer Center, CPB5.3200, Unit 1350, 1515 Holcombe Blvd, Houston, TX 77030. National Engineering Research Centre for Tissue Restoration and Reconstruction South China University of Technology Guangzhou 510006 P. R. China Department of Proctology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China Department of Anesthesiology Duke University School of Medicine Durham North Carolina USA College of Animal Science and Veterinary Medicine , Daqing China Department of Chemistry, Center for Drug Design, Georgia State University, Atlanta, Georgia 30303 Stanford University School of Medicine, Department of Pediatrics, Division of Neonatology Stanford University School of Medicine Stanford California USA Department of Genetics, Genome Technology Access Center at the McDonnell Genome Institute, Washington University School of Medicine , St. Louis, Missouri 63110 , USA School of Biomedical Engineering, Southern Medical University, Guangzhou, Guangdong, China School of Materials Science & Engineering, Beijing Institute of Technology, Beijing 100081, China Jiangxi Cancer Hospital, Nanchang 330029, China 3Department of Genetics, Washington University School of Medicine, St. Louis, MO Department of Pediatrics, Division of Neonatology and Developmental Medicine Stanford University School of Medicine Stanford California USA University of Science and Technology of China; Chinese Academy of Sciences Wei Yang, Kun Yan, Wei Wu, Ying Fu, Jung-Chieh Lee, Zhong-Yi Zhang, Song Wang, Min-Hua Chen, Department of Ultrasound, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital and Institute, Beijing 100142, China. Department of Neurology, The Second Hospital of Jilin University, Changchun, Jilin, China Department of Surgery and Biomedical Sciences Cedars Sinai Cancer Institute Los Angeles California University Office, Zhejiang University, Hangzhou 310058, People's Republic of China; and; Department of Engineering Mechanics, Tsinghua University, Beijing 100084, People's Republic of China Department of Geriatric Medicine The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an Shaanxi China Department of Pathophysiology, Key Laboratory of Cardiovascular Pathophysiology, Harbin Medical University, Harbin 150081, China Department of Molecular and Systems Biology, Norris Cotton Cancer Center, Dartmouth-Hitchcock Medical Center, Geisel School of Medicine at Dartmouth, Lebanon, NH, USA Department of Internal Medicine The University of Texas Health Science Center at Houston McGovern Medical School Houston TX USA Wei Yang, Professor, Division of Epidemiology, Biostatistics, and Environmental Health, School of Community Health Sciences, University of Nevada, Reno, Reno, NV, United States;, Email: weiyang@unr.edu Phase I Clinical Trial Laboratory, Affiliated Hospital of Changchun University of Chinese Medicine, Jilin, China Department of Pediatrics, Division of Neonatology Stanford University School of Medicine Stanford California USA Department of Neurosurgery, Beijing Children's Hospital Capital Medical University, National Center for Children's Health Beijing China Institute of Chinese Medicinal Materials, Nanjing Agricultural University, Nanjing 210095, China. 2011 Collaborative Innovation Center of Tianjin for Medical Epigenetics, Key Laboratory of Hormone and Development (Ministry of Health), Metabolic Disease Hospital & Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin 300070, China Surgical Oncology Department, Beijing Children's Hospital Capital Medical University, National Center for Children's Health Beijing China The State Key Laboratory of Electroanalytic Chemistry, Chinese Academy of Sciences, Changchun Institute of Applied Chemistry, Changchun, 130022, People's Republic of China State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, International School of Materials Science and Engineering, Wuhan University of Technology, Luoshi Road 122, Wuhan 430070, People’s Republic of China Key Laboratory of Horticultural Plant Biology (Ministry of Education), Key Laboratory of Horticultural Crop Biology and Genetic Improvement (Central Region), MOA, PR China, College of Horticulture and Forestry Science, Huazhong Agricultural University, Wuhan 430070, People’s Republic of China Xiamen University School of Electronic and Information Engineering, Beijing Jiaotong University, Beijing 100044, China Division of Population Genetics and Prevention, Cardiovascular Institute, Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 167 Beilishi Road, Beijing 100037, People's Republic of China; National Human Genome Center at Beijing, North Yongchang Road 3-707, Beijing 100176, People's Republic of China Institute of Applied Physics and Computational Mathematics 1 , Beijing 100088, People's Republic of China Shenzhen University College of Materials Science and Engineering CHINA Jiangsu Collaborative Innovation Center of Regional Modern Agriculture & Environmental Protection Huai'an China; Jiangsu Key Laboratory for Eco‐Agricultural Biotechnology around Hongze Lake Huaiyin Normal University Huai'an China Department of intensive care unit School of Chemical and Material Engineering, Bohai University, Jinzhou, 121013, Liaoning, China; Liaoning Key Laboratory of Engineering Technology Research Center of Silicon Materials, Jinzhou, 121013, Liaoning, China Beijing System Design Institute of Mechanical-Electrical Engineering, Beijing 100871, China Shantou University Medical College, China (W.Y., S.Y.). Department of Chemistry; South University of Science and Technology; Shenzhen; China Department of Cardiovascular Medicine, First Hospital, Jilin University, Jilin, PR China Paul C. Lauterbur Research Center for Biomedical Imaging, Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China Department of Biostatistics, Epidemiology, and Informatics and; Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; and Center for Real‐world Effectiveness and Safety of Therapeutics and the Center for Clinical Epidemiology and Biostatistics Perelman School of Medicine, University of Pennsylvania Philadelphia Pennsylvania USA; Department of Biostatistics, Epidemiology, and Informatics Perelman School of Medicine, University of Pennsylvania Philadelphia Pennsylvania USA State Key Laboratory of Mycology; Institute of Microbiology; Chinese Academy of Sciences; Beijing China; University of Chinese Academy of Sciences; Beijing China Department of Cardiology, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, China Institute of Molecular Biophysics, Florida State University, Tallahassee, Florida 32306, Department of Chemistry and Biochemistry, Florida State University, Tallahassee, Florida 32306 Department of Biostatistics and Epidemiology, Center for Clinical Epidemiology and Biostatistics University of Pennsylvania Perelman School of Medicine Philadelphia PA 19104 U.S.A. Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, United States Wenzhou Medical College, Wenzhou, Zhejiang Province, China. NHC Key Laboratory of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research) Fudan University Shanghai P.R. China School of Biomedical Engineering, Southern Medical University, Guangzhou, China Department of General Surgery, Affiliated Tumor Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, Henan, PR China Institute of Physics and Beijing National Laboratory for Condensed Matter Physics Chinese Academy of Sciences Beijing 100190 China; School of Physical Sciences University of Chinese Academy of Sciences Beijing 100190 China; Songshan Lake Materials Laboratory Dongguan Guangdong 523808 China; Beijing Key Laboratory for Nanomaterials and Nanodevices Beijing 100190 China Department of Hematology, Shengjing Hospital, China Medical University, China Multidisciplinary Neuroprotection Laboratories, Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina, USA Department of Cardiology, First Affiliated Hospital of Dali University, Dali, Yunnan, China College of Animal Science and Veterinary Medicine, Jilin University, 5333 Xi’an Road, Changchun 130062, People's Republic of China Guangdong Provincial Key Laboratory of Medical Image Processing, School of Biomedical Engineering, Southern Medical University , Guangzhou 510515, China Division of Infection and Immunology, Laboratory Animals Center, Fourth Military Medical University, Xi'an, Shaanxi Province, China. Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania USA Department of Hematology, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, P.R. China Department of Radiation Oncology, The First Medical Center, Chinese PLA General Hospital, Beijing 100853, China Department of Rehabilitation Medicine Institute of Molecular Biophysics and; Department of Chemistry and Biochemistry, Florida State University, Tallahassee, FL 32306; College of Life Sciences, Nankai University, Tianjin 300071, People's Republic of China Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, Beijing 100083, China; School of Nanoscience and Technology, University of Chinese Academy of Sciences, Beijing 100049, China Molecular Neurobiology Laboratory Department of Anesthesiology Duke University Medical Center Durham NC USA Department of Respiratory Diseases, Peking University Third Hospital, Beijing, People's Republic of China Guangdong Key Laboratory of Animal Conservation and Resource Utilization, Guangdong Public Laboratory Wild Animal Conservation and Utilization Guangdong Institute of Applied Biological Resources Guangzhou China; Department of Medical Laboratory Science The Fifth People's Hospital of Wuxi, Nanjing Medical University Wuxi China Department of Clinical Laboratory, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, China. School of Life Science Huaibei Normal University Huaibei China Department of Anorectal Surgery, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 201210, China Department of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL 35294 Beijing Key Laboratory of Functional Food from Plant Resources, College of Food Science & Nutritional Engineering, China Agricultural University, Beijing 100083, P. R. China State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116024, China State Key Laboratory of Heavy Oil Processing and the Centre for Bioengineering and Biotechnology China University of Petroleum (East China) Changjiang West Road Qingdao 266580 China CAMBIA, Canberra, Australian Capital Territory 2601, Australia (W.Y., R.A.J., E.H.); Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724 (J.M.M., W.B.G., U.G.); and Institute of Plant Biology, University of Zürich, CH–8008 Zurich, Switzerland (U.G.) CBR Institute for Biomedical Research and Departments of Pathology and Anesthesia, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115 Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, Alabama, USA College of Polymer Science and Engineering; Sichuan University; Chengdu 610065; China; State Key Laboratory of Polymer Materials Engineering Department of Laboratory Medicine, First Affiliated Hospital, Chongqing Medical University, Chongqing 400016, China. State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China Jilin Provincial Key Laboratory on Molecular and Chemical Genetics, The Second Hospital of Jilin University, Changchun 130041, PR China Key Laboratory of Modern Precision Agriculture System Integration Research, Ministry of Education, China Agricultural University, Beijing 100083, China. weiwei810311@163.com Department of Neurosurgery, Daping Hospital and Institute Research of Surgery, Army Medical University, Chongqing 400042, P.R. China Department of Clinical Laboratory Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing) Beijing P.R. China Department of Clinical Research, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine Sun Yat‐sen University Cancer Center Guangzhou China Key Laboratory of Functional Polymer Materials (Nankai University), Ministry of Education, Nankai University, Tianjin 300071, P. R. China, and Research Centre for Analytical Sciences, Department of Chemistry, Nankai University, Tianjin 300071, P. R. China Beijing Key Laboratory of Environment Science and Engineering School of Material Science and Engineering Beijing Institute of Technology Collaborative Innovation Center of Electric Vehicles in Beijing Beijing 100081 China Department of Global Health and Social Medicine, Faculty of Social Science and Public Policy, King’s College London Department of Biochemistry, University of Washington, Seattle, Washington 98195, United States; Institute for Protein Design, University of Washington, Seattle, Washington 98195, United States Department of Diagnostic Radiology University of Texas Houston TX USA Beijing National Laboratory for Condensed Matter Physics, Key Laboratory for Nanoscale Physics and Devices, Institute of Physics, Chinese Academy of Sciences, Beijing 100190, China; School of Physical Sciences, University of Chinese Academy of Sciences, Beijing 100190, China; Beijing Key Laboratory for Nanomaterials and Nanodevices, Beijing 100190, China The Second Affiliated Hospital The State Key Laboratory of Respiratory Disease Guangdong Provincial Key Laboratory of Allergy & Clinical Immunology Guangzhou Medical University Guangzhou China; Institute of Biomedical Engineering The Second Clinical Medical College (Shenzhen People's Hospital) of Jinan University Shenzhen China Center for Environmental Remote Sensing Chiba University Chiba‐shi Chiba 263‐8522 Japan State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, International School of Materials Science and Engineering, Wuhan University of Technology, Wuhan 430070, China College of Health Science and Engineering, Hubei University, Wuhan 430062, P. R. China Department of Materials Science, Fudan University, Shanghai 200433, P. R. China State Key Laboratory of Fluid Power & Mechatronic System, Key Laboratory of Soft Machines and Smart Devices of Zhejiang Province, Center for X-Mechanics, and Department of Engineering Mechanics, Zhejiang University, Hangzhou 310027, China. Key Laboratory of Auxiliary Chemistry & Technology for Chemical Industry, Ministry of Education, Shaanxi University of Science & Technology, Xi’an 710021, China Department of Cardiology, Heart Center of Henan Provincial People’s Hospital, Central China Fuwai Hospital, Central China Fuwai Hospital of Zhengzhou University, Zhengzhou, China; Henan Key Lab for Prevention and Control of Coronary Heart Disease, Central China Fuwai Hospital of Zhengzhou University, Zhengzhou, China Jiangsu Key Laboratory for Eco-Agricultural Biotechnology Around Hongze Lake, Jiangsu Collaborative Innovation Center of Regional Modern Agriculture and Environmental Protection, School of Life Science, Huaiyin Normal University, Huaian 223300, China Key Laboratory of Zoonosis Ministry of Education College of Veterinary Medicine Jilin University 5333 Xi'an Road Changchun Jilin 130062 China Department of Oncology, The Third Affiliated Hospital of Shenzhen University, Shenzhen, Guangdong 518000, P.R. China Environmental Sciences Graduate Program University of Nevada Reno Nevada; School of Community Health Sciences, University of Nevada Reno Nevada State Key Laboratory of Agricultural Microbiology, College of Life Science and Technology, Huazhong Agricultural University, Wuhan, P. R. China Clinical Trails Center, The Affiliated Hospital of Guizhou Medical University, Guiyang, China; State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Provincial Key Laboratory of Pharmaceutics, Guizhou Medical University, Guiyang, China Advanced Materials Institute, Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, China Laboratory of Advanced Optoelectronic Materials, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, Jiangsu 215123, P. R. China Department of ICU, Jingjiang People’s Hospital, Jingjiang, Jiangsu, China School of Community Health Sciences, University of Nevada, Reno, Nevada Center for Health Statistics and Informatics, University of Nevada, Reno Multidisciplinary Neuroprotection Laboratories, Department of Anesthesiology, Duke University Medical Center, Durham, NC, USA Center of Bioinformatics, Northwest A&F University, Yangling, Shaanxi, China College of Pharmaceutical Science, Zhejiang Chinese Medical University, Hangzhou, China;; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang Province, China Department of Diagnostic Radiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. Department of Hematology, Shengjing Hospital of China Medical University, Liaoning, China Department of Respiratory Medicine, Putuo Hospital Affilated Shanghai University of Traditional Chinese Medicine Shanghai China School of Community Health Sciences, University of Nevada, Reno, NV; State Key Laboratory of Luminescent Materials and Devices, and Institute of Polymer Optoelectronic Materials and Devices, South China University of Technology, Guangzhou 510640, China f Diagnostic Radiology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA; Department of Neurosurgery Daping Hospital & Research Institute of Surgery Third Military Medical University Chongqing China Jilin Provincial Key Laboratory on Molecular and Chemical Genetic, The Second Hospital of Jilin University, Ziqiang Street No. 218. Changchun, 130041, China Department of Ultrasound Key Laboratory of the Ministry of Education for Carcinogenesis and Translational Research, Peking University Cancer Hospital & Institute Beijing China Clinical Center for Tumor Therapy, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, P.R. China Department of Materials Science; Fudan University; Shanghai 200433; China Leibniz Institute for Solid State and Materials Research, Helmholtzstraße 20, 01069 Dresden, Germany; College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, Jiangsu, 215123, P. R. China Sichuan Agricultural University, Key Laboratory of Ecological Forestry Engineering of Sichuan Province/ College of Forestry, Chengdu, Sichuan, China Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305, USA Department of Biophysics and Department of Neurology of the Fourth Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310000, P.R. China. Department of General Surgery, Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, Henan Province 450008, China Department of Chemistry and Biochemistry Florida State University Tallahassee Florida USA; Institute of Molecular Biophysics Florida State University Tallahassee Florida USA Institute of Chinese Materia Medica China Academy of Chinese Medical Sciences Beijing China College of Landscape Architecture, Sichuan Agricultural University, Chengdu 625014, China School of Pharmacology, Shenyang Pharmaceutical University, Shenyang. Jilin Provincial Key Laboratory on Molecular and Chemical Genetic, Second Hospital of Jilin University, Changchun, People's Republic of China Global Energy Interconnection Research Institute Co., Ltd., Beijing 102209, P. R. China Department of Hematology, Shengjing Hospital of China Medical University, Shenyang, China. Professor of Zhejiang University and Former President of the National Natural Science Foundation of China Department of Microbiology, School of Basic Medical Sciences, Capital Medical University , Beijing, China; Department of Neurosurgery, Capital Medical University Sanbo Brain Hospital , Beijing, China Center for Pharmacoepidemiology Research and Training Perelman School of Medicine at the University of Pennsylvania Philadelphia Pennsylvania USA; Center for Clinical Epidemiology and Biostatistics Perelman School of Medicine at the University of Pennsylvania Philadelphia Pennsylvania USA; Department of Biostatistics, Epidemiology, and Informatics Perelman School of Medicine at the University of Pennsylvania Philadelphia Pennsylvania USA College of Polymer Science & Engineering, and The State Key Laboratory of Polymer Materials Engineering; Sichuan University; Chengdu 610065; P. R. China Department of Gastrointestinal Surgery Medical Research Institute Zhongnan Hospital of Wuhan University Wuhan 430071 China; Department of Pulmonary and Critical Care Medicine Zhongnan Hospital of Wuhan University Wuhan 430071 China; Frontier Science Center for Immunology and Metabolism Wuhan University Wuhan 430071 China; Department of Virology College of Life Sciences Wuhan University Wuhan 430072 China; Wuhan Research Center for Infectious Diseases and Cancer Chinese Academy of Medical Sciences Wuhan 430071 China W. Fraser Symmans, Caimiao Wei, Rebekah Gould, Xian Yu, Ya Zhang, Maheshwari Ramineni, Kelly Hunt, Thomas A. Buchholz, Vicente Valero, Aman U. Buzdar, Wei Yang, Abenaa M. Brewster, Stacy Moulder, and Gabriel N. Hortobagyi, University of Texas MD Anderson Cancer Center, Houston; Andrew Walls, Uniformed Services University of the Health Sciences, San Antonio, TX; Mei Liu, The General Hospital of People’s Liberation Army, Beijing, China; Alex Bousamra, Allegheny General Hospital, Pittsburgh, PA; Bruno Sinn,... Key Laboratory of Earth and Planetary Physics, Institute of Geology and Geophysics, Chinese Academy of Sciences, Beijing 100029, China Department of Cardiology Zhengzhou University Central China Fuwai Hospital Zhengzhou Henan China Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, 274 Zhijiang Road, Shanghai 200071, China Department of Biostatistics and Epidemiology Center for Clinical Epidemiology and Biostatistics University of Pennsylvania School of Medicine Philadelphia PA USA 2Tianjin Key Laboratory of Molecular Drug Research, Tianjin International Joint Academy of Biomedicine, Tianjin, China. School of Physics and Electronic Engineering, Anqing Normal University, Anqing 246011, P. R. China *Department of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL; and Department of Pediatrics, Stanford University School of Medicine, Stanford, California Cancer Hospital of Shantou University Medical College, Guangdong Province, People's Republic of China School of Food Science Henan Institute of Science and Technology Xinxiang China School of Municipal & Environmental Engineering, Harbin Institute of Technology, Harbin 150090, China. yangweixx@163.com Department of Cardiovascular Surgery The Second Affiliated Hospital of Nanchang University Nanchang China Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen University Town, Xili, Shenzhen 518055, China Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, USA Oncology Department of Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200071, China Department of General Surgery, Affiliated Tumor Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, Henan, China Department of Immunology School of Basic Medical Sciences Fudan University Shanghai China Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania (W.Y.) Department of Medicine, University of California Irvine, Orange, CA, USA; Department of Urology, Third Affiliated Hospital of The Second Military Medical University, Shanghai 200433, P.R. China Ultrasound Department, School of Oncology, Peking University, Beijing 100036, China. Fert Beijing Research Institute; MIIT Key Laboratory of Spintronics; School of Integrated Circuit Science and Engineering & Beijing Advanced Innovation Center for Big Data and Brain Computing; Beihang University; Beijing 100191 State Key Laboratory of Chem/Biosensing and Chemometrics Advanced Catalytic Engineering Research Center of the Ministry of Education College of Chemistry and Chemical Engineering Hunan University Changsha 410082 China Ultrasound Department of Clinical Oncology School, Peking University, Beijing 100036, China. Liver Immunology Laboratory, Institute of Immunology and The CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China, Hefei, China Division of Biotechnology, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, Liaoning, China. Preventive Treatment of Disease Center, Liuzhou Traditional Chinese Medical Hospital, Liuzhou, Guangxi Zhuang Autonomous Region, China Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062, China Department of Clinical Laboratory, Zhejiang Provincial People’s Hospital Bijie Hospital, Bijie, Guizhou, China Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, Pennsylvania Urological Diseases Research Center, Department of Urology, Children’s Hospital Boston, Boston, Massachusetts 02115, Department of Surgery, Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, Proteomics Center, Children’s Hospital Boston, Boston, Massachusetts 02115, Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, Department of Clinical Oncology, Prince of Wales Hospital, the Chinese University of... Department of Neurosurgery Beijing Children's Hospital, Capital Medical University Beijing China College of Biological and Pharmaceutical Science China Three Gorges University Yichang China Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892; Department of General Surgery, Affiliated Tumor Hospital of Zhengzhou University, Henan Cancer Hospital, Henan, Zhengzhou Authors' Affiliations: 1Department of Breast Surgery, Shanghai Cancer Center and Cancer Institute of Fudan University, Shanghai, China; 2Department of Systems Medicine and Bioengineering, The Methodist Hospital Research Institute; 3The Methodist Hospital Cancer Center; 4The University of Texas MD Anderson Cancer Center, Houston, Texas; 5Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, Tennessee; and 6Mount Vernon Hospital, London, United Kingdom Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Kaul Human Genetics Building Room 430, 720 South 20th Street South, Birmingham, AL 35294; Department of Pediatrics, Division of Neonatal and Developmental Medicine, Stanford University School of Medicine, Stanford, California; Lanzhou University, Lanzhou, China; Department of Gastroenterology, The First Hospital of Lanzhou University, Lanzhou, China; Key Laboratory for Gastrointestinal Diseases of Gansu Province, Lanzhou University, Lanzhou, China. College of Chemistry and Molecular Sciences Key Laboratory of Biomedical Polymers of, Ministry of Education The Institute for Advanced Studies Hubei Province Key Laboratory of Allergy and Immunology Wuhan University Wuhan Hubei 430072 P. R. China State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, People's Republic of China and College of Chemistry Chemical Engineering and Materials Science Soochow University Suzhou Jiangsu 215123 P. R. China Key Laboratory of Protein and Peptide Pharmaceuticals, CAS‐University of Tokyo Joint Laboratory of Structural Virology and Immunology, Institute of Biophysics, Chinese Academy of Sciences University of the Chinese Academy of Sciences Beijing PR China Department of Pediatrics; Division of Neonatology; Stanford University School of Medicine; Stanford California Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, 20 Penn Street, Baltimore, Maryland 21201, United States Beijing National Laboratory for Condensed Matter Physics and Institute of Physics, Chinese Academy of Sciences, Beijing 100190, China Department of Chemistry, State University at Stony Brook, Stony Brook, New York, 11794-3400 Institute of Molecular Biophysics and ‡Department of Chemistry and Biochemistry, Florida State University, Tallahassee, Florida 32306, United States School of Community Health Sciences University of Nevada Reno Nevada Department of Diagnostic Radiology, University of Texas, Houston, Texas, USA Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, Shaanxi, China; Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, Shaanxi, China Engineering Technology Research Center of Magnetic Materials of Anhui Province; School of Physics & Materials Science; Anhui University; Hefei 230601; China Institute of Tibetan Plateau Research, Chinese Academy of Sciences, Beijing 100101, China Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Ultrasound, Peking University Cancer Hospital & Institute, Beijing, China; Peking University 1 The State Key Laboratory for Artificial Microstructures and Mesoscopic Physics, School of Physics, , Beijing 100871, China; Peking University 2 Center for Quantitative Biology, Academy for Advanced Interdisciplinary Studies, , Beijing 100871, China College of Chemistry and Molecular Sciences, Key Laboratory of Biomedical Polymers of Ministry of Education, Wuhan University, Wuhan, China MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China Key Laboratory of Drug‐Targeting and Drug Delivery Systems Ministry of Education West China School of Pharmacy Sichuan University Chengdu China Peking University Stem Cell Research Center and Cell Biology Department, Beijing, China School of Biomedical Engineering, Southern Medical University, Guangzhou, China. Electronic address: weiyanggm@gmail.com. Institute of Tibetan Plateau Research, Chinese Academy of Sciences, 100101 Beijing, China Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania; Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing) Department of Ultrasound, Peking University Cancer Hospital & Institute, Beijing, China Department of Neurobiology, Key Laboratory of Medical Neurobiology of the Ministry of Health of China, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, China 1 Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138 Key Laboratory of Building Safety and Energy Efficiency of the Ministry of Education, College of Civil Engineering, Hunan University, Changsha 410082, China; National Center for International Research Collaboration in Building Safety and Environment, Hunan University, Changsha 410082, China; College of Civil Engineering, Hunan University, Changsha 410082, China Guangdong Institute of Applied Biological Resources, China State Key Laboratory of Agricultural Microbiology, Hubei Hongshan Laboratory, the Provincial Key Laboratory of Plant Pathology of Hubei Province, College of Plant Science & Technology, Huazhong Agricultural University, Wuhan 430070, China Department of Proctology, Shuguang Hospital Affiliated to Shanghai University of TCM, Shanghai 201203. Institute of Applied Mechanics, Zhejiang University, Hangzhou 310027, China Department of Ultrasound, School of Oncology, Peking University, 52 Fu-cheng Rd., Beijing 100036, People's Republic of China. State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Science, Changchun 130022, P. R. China; School of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei 230026, P. R. China First Affiliated Hospital of the Medical School of Xi'an Jiaotong University, and Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, Medical School of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; Department of Biophysics, and Department of Neurosurgery of the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, P. R. China College of Material Chemistry and Chemical Engineering, and Key Laboratory of Organosilicon Chemistry and Material Technology of Ministry of Education, Hangzhou Normal University Wei Yang is president of the National Natural Science Foundation of China and a professor in the Institute of Applied Mechanics at Zhejiang University, Hangzhou, China. College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, Hubei, China Laboratory of Molecular Biology, NIDDK; National Institutes of Health; Bethesda Maryland Hainan Provincial Fine Chemical Engineering Research Center, Hainan University, Haikou 570228, China; Hainan Xiangtai Fishery Co., Ltd., South of Yutang Road, Industrial Avenue, Laocheng Development Zone, Chengmai City 571924, China Department of Rehabilitation Medicine Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College Hangzhou China Department of Neurosurgery Shandong Provincial Hospital affiliated to Shandong University Jinan China Department of Laboratory Medicine, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, People’s Republic of China Shandong Weigao Group National Engineering Lab Weihai China Beijing Institute of Technology Beijing Institute of Technology School of Materials Science and Engineering Beijing 100081 China Intensive Care Unit, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China From the State Key Laboratory of Medical Neurobiology and Institute of Brain Science (W.Z., W.Y., Y.G., J.C.), Fudan University, Shanghai, China; the Department of Neurology and Center of Cerebrovascular Disease Research (W.Z., X.H., Y.G., J.C.), University of Pittsburgh School of Medicine, Pittsburgh, Pa; and the Geriatric Research, Educational and Clinical Center (X.H., J.C.), Veterans Affairs Pittsburgh Health Care System, Pittsburgh, Pa. Center for Perioperative Organ ProtectionDepartment of AnesthesiologyDuke University Medical Center Durham North Carolina USA Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China School of Community Health Sciences, University of Nevada, Reno, Nevada, USA State Key Laboratory of Fire Science, University of Science and Technology of China, 96 Jinzhai Road, Hefei, Anhui 230026, People’s Republic of China; Department of Chemical and Materials Engineering, Hefei University, 99 Jinxiu Road, Hefei, Anhui 230601, People’s Republic of China *Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases and State Key Laboratory of Advanced Technology for Materials Synthesis and Processing; Wuhan University of Technology; Wuhan 430070; China Proteome Group, National Laboratory of Protein Engineering, Peking University, Beijing 100871, PRC China Tobacco Yunnan Industrial Co. Ltd, Kunming, 650231, PR China Department of Nephrology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China From the Division of Cardiology, Department of Pediatrics, The Children’s Hospital of Philadelphia and the University of Pennsylvania Perelman School of Medicine, Philadelphia, PA (L.M.-R., J.R., M.F., E.G.); Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA (W.Y.); and Division of Pediatric Cardiology, Children’s Hospital and Medical Center, University of Nebraska College of Medicine, Omaha, NE (S.K.) Radiobiology Research Unit of Ministry of Health, School of Public Health, Jilin University, Changchun 130021, China. The Center for Drug Research and Development, Guangdong Pharmaceutical University, Guangzhou, China;; Department of Pharmaceutics, Guangdong Provincial Engineering Center of Topical Precise Drug Delivery System, Guangdong Pharmaceutical University, Guangdong, China;; Guangdong Provincial Key Laboratory of Advanced Drug Delivery Systems, Guangdong Pharmaceutical University, Guangdong, China; Key Laboratory of Horticultural Plant Biology Ministry of Education Huazhong Agricultural University Wuhan Hubei 430070 China; Key Laboratory of Horticultural Crop Biology and Genetic improvement (Central Region) Ministry of Agriculture Huazhong Agricultural University Wuhan Hubei 430070 China; The Institute of Citrus Science Huazhong Agricultural University Wuhan Hubei 430070 China Department of Infectious Diseases, Institute of Virology, University of Veterinary Medicine Hannover, Foundation, Hannover, Germany; College of Veterinary Medicine, Northeast Agricultural University, Harbin, China College of Chemistry and Molecular Sciences, Key Laboratory of Biomedical Polymers of Ministry of Education, The Institute for Advanced Studies, Hubei Province Key Laboratory of Allergy and Immunology, Wuhan University, Wuhan, Hubei 430072, P. R. China 2Department of Genetics, Washington University School of Medicine, St. Louis, Missouri. Department of Anesthesiology Duke University Medical Center Durham NC USA Department of Physiology, Key Laboratory of Cellular Physiology, Ministry of Education, Shanxi Medical University, Taiyuan, PR China Department of Pediatrics Stanford University School of Medicine Palo Alto California USA Key Laboratory of External Drug Delivery System and Preparation Technology in Universities of Yunnan, Yunnan University of Chinese Medicine, Kunming 650500, China; Faculty of Chinese Materia Medica, Yunnan University of Chinese Medicine, Kunming 650500, China School of Community Health Sciences, University of Nevada, Reno, 1664 North, Virginia Street, MS 274, Reno, NV 89557, USA Department of Anesthesiology, Duke University Medical Center, Durham, NC, USA Department of Physiology, Xi'an Jiaotong University, Shanxi Xi'an, China. Lanzhou University; Department of Gastroenterology, the First Hospital of Lanzhou University; Key Laboratory for Gastrointestinal Diseases of Gansu Province, Lanzhou University, Lanzhou, China Department of Pediatrics, School of Medicine, Stanford University, Stanford, California Division of Biostatistics Washington University School of Medicine St. Louis Missouri United States of America Department of Cell Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-2175, and Veterans Affairs Medical Center, Nashville, Tennessee 37212-2637 Division of Neonatology, Department of Pediatrics, Stanford University School of Medicine, Stanford, California; School of Physical Education and Sport Science, Fujian Normal University, Fuzhou, China College of Veterinary Medicine, Northeast Agricultural University, Harbin, China. Fert Beijing Institute, MIIT Key Laboratory of Spintronics, School of Integrated Circuit Science and Engineering, Beihang University, Beijing 100191, China Department of Anorectal Surgery Shuguang Hospital, Shanghai University of Traditional Chinese Medicine Shanghai China Department of Systems Biomedicine and Pharmacology Leiden Academic Centre for Drug Research (LACDR) Leiden University Leiden the Netherlands Department of Oncology Surgery, Beijing Children's Hospital Capital Medical University, National Center for Children's Health Beijing China School of Biomedical Sciences, Faculty of Biological Sciences, University of Leeds, Leeds, United Kingdom;; School of Medicine, Zhejiang University, Hangzhou, China; and Department of Endocrinology and Metabology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Ji'nan, China. Department of Neurology, The Second Hospital of Jilin University, Changchun, China Department of Environmental Engineering, Peking University, Beijing 100871, People’s Republic of China, and The Key Laboratory of Water and Sediment Sciences, Ministry of Education, Beijing 100871, People’s Republic of China Department of Biophysics Department of Neurology of the Fourth Affiliated Hospital Zhejiang University School of Medicine Hangzhou 310058 China; MOE Frontier Science Center for Brain Research and Brain‐Machine Integration Zhejiang University School of Medicine Hangzhou 310058 China Division of Neonatal and Developmental Medicine Department of Pediatrics Stanford University School of Medicine Stanford California Guangdong Key Laboratory of Animal Conservation and Resource Utilization, Guangdong Public Laboratory Wild Animal Conservation and Utilization Guangdong Institute of Applied Biological Resources Guangzhou China; Department of Medical Laboratory Science The Fifth People’s Hospital of Wuxi, The Medical School of Jiangnan University Wuxi Jiangsu China Department of Cardiothoracic Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China Jilin Provincial Key Laboratory on Molecular and Chemical Genetic, The Second Hospital of Jilin University, Changchun, Jilin, China Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College Huazhong University of Science and Technology Wuhan China Department of Pediatrics Stanford University Stanford California College of Chemistry; Dalian University of Technology; Dalian 116023; P. R. China Office of Drug Clinical Trial Institution, First Affiliated Hospital of Jinan University, Guangzhou, China. Key Laboratory of Horticultural Plant Biology (Ministry of Education), Huazhong Agricultural University, 430070 Wuhan, China Department of Biostatistics and Epidemiology, and Florida State University 1 Department of Chemistry and Biochemistry, , Tallahassee, Florida 32306, USA; Florida State University 2 Institute of Molecular Biophysics, , Tallahassee, Florida 32306, USA Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States Nephrology Department, Shanxi Traditional Chinese Medicine Institute, Shanxi, China Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, China; MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, China Department of Chemistry, Center of Drug Design and Advanced Biotechnology, Georgia State University, Atlanta, Georgia 30303, and Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts 02115 Center for Clinical Epidemiology and Biostatistics University of Pennsylvania Philadelphia Pennsylvania Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases and Department of Physical examination , Shenzhen Hospital of Beijing University of Chinese Medicine (Longgang) , Shenzhen , Guangdong , China School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, China. ethanyang@yahoo.cn State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, School of Material Science and Engineering, Wuhan University of Technology, Wuhan 430070, China Department of Chemistry & Biochemistry, Florida State University, Tallahassee, Florida 32306, United States; Institute of Molecular Biophysics, Florida State University, Tallahassee, Florida 32306, United States Breast Center, Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei�050035, P.R.�China Division of Neonatal and Developmental Medicine, Department of Pediatrics, Stanford University School of Medicine, Palo Alto, CA, USA Medical School, Jinan University, 601 Huangpu Road West, Guangzhou, Guangdong 510632, China Department of Biostatistics and Epidemiology and; Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; 1Division of Cancer Biology and Therapeutics, Department of Surgery and Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California. Shantou University Medical College, China (W.Y., J.C., S.Y.). Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, and; MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China State Key Laboratory of North China Crop Improvement and Regulation, Key Laboratory for Farmland Eco-Environment of Hebei Province, Hebei Collaborative Innovation Center for Green & Efficient Vegetable Industry, College of Resources and Environmental Science, Hebei Industrial Technology Institute of Microbial Fertilizers, Hebei Agricultural University, Baoding 071000, China National Key Laboratory of Agricultural Microbiology, Hubei Hongshan Laboratory, Hubei Key Laboratory of Plant Pathology, The Center for Crop Nanobiotechnology Huazhong Agricultural University Wuhan China The CBR Institute for Biomedical Research and Department of Pathology, Harvard Medical School, Boston, MA 02115 College of Information and Communication Engineering, Harbin Engineering University , Harbin 150001, China School of Chemistry and Chemical Engineering, Guangzhou University, Guangzhou 510006, China School of Economics and Management, Liaoning University of Technology, Jinzhou 121001, China School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong Special Administrative Region 999077, P. R. China Center for Real‐World Effectiveness and Safety of Therapeutics and the Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania USA; Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania USA Department of Agronomy Jilin Agricultural University Changchun 130118 China Nanoscale Physics and devices Laboratory, Beijing National Laboratory for Condensed, Matter Physics and Institute of Physics Chinese Academy of Sciences Beijing 100190 China National Engineering Research Center for Optical Fiber Sensing Technology and Networks, School of Material Science and Engineering, Wuhan University of Technology, Wuhan 430070, China From the Second Department of Neurology (F.Z., K.W.), Xinxiang Central Hospital, Henan Province; Department of Anorectal Surgery (P.D., W.Y., Z.M.), Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine; Anorectal Disease Institute of Shuguang Hospital (P.D., W.Y., Z.M.), Shanghai, China; Usher Institute of Population Health Sciences (Y.H.), University of Edinburgh, UK; and School of Basic Medicine (T.L.), Fourth Military Medical University, Xi'an, China. Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Ultrasound, Peking University Cancer Hospital and Institute, Haidian District, Beijing, China; State Key Laboratory of Organic Electronics and Information Displays & Institute of Advanced Materials (IAM) Nanjing University of Posts & Telecommunications (NJUPT) Nanjing 210023 P. R. China Key Laboratory of Biomaterials of Guangdong Higher Education Institutes, Department of Biomedical Engineering, Jinan University, Guangzhou 510632, China *Department of Cell, Developmental, and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL 35294; and Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Ultrasound, Peking University Cancer Hospital & Institute, Beijing 100191, China State Key Laboratory of Fluid Power & Mechatronic System, Key Laboratory of Soft Machines and Smart Devices of Zhejiang Province, Center for X-Mechanics, and Department of Engineering Mechanics, Zhejiang University, Hangzhou 310027, China College of Chemistry and Molecular Sciences, Key Laboratory of Biomedical Polymers of Ministry of Education, Wuhan University, Wuhan, Hubei, 430072, P. R. China MOE International Joint Laboratory of Materials Microstructure Institute for New Energy Materials and Low Carbon Technologies School of Materials Science and Engineering Tianjin University of Technology Tianjin 300384 China Division of Biostatistics Washington University School of Medicine Missouri United States of America Isotope Laboratory, Department of Geosciences University of Arkansas Fayetteville AR 72701 USA; Key Laboratory of the Earth's Deep Interior Institute of Geology and Geophysics, Chinese Academy of Sciences P.O. Box 9825 Beijing 100029 China Department of Endocrinology, Genetics and Metabolism, Children’s Hospital Affiliated to Zhengzhou University, Henan Children’s Hospital, Zhengzhou Children’s Hospital, Zhengzhou, China School of Resources Engineering, Xi'an University of Architecture and Technology, Xi'an 710055, People's Republic of China Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan 430030, PR China. Department of Immunology, College of Basic Medical Sciences, JiLin University, Changchun City, Jilin Province, China Department of Cardiothoracic Surgery, The Second Affiliated Hospital of Nanchang University Nanchang 330008, China. Department of Endocrinology, The First Affiliated Hospital of Shandong First Medical University, Ji’nan, Shandong, China. School of Materials Science and Engineering, Beijing Institute of Technology, Beijing, 100081, China Department of TCM, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China The Environmental Sciences and Health Graduate Program, University of Nevada, Reno, NV 89557-0186, USA; School of Community Health Sciences, University of Nevada, Reno, NV 89557-0274, USA Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China Henan University, School of Computer and Information Engineering, Kaifeng, Henan, China China Rehabilitation Research Center, Beijing, China College of Landscape Architecture, Sichuan Agricultural University, Chengdu, Sichuan 611130, China From University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania; Stanford University School of Medicine, Stanford, California; National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland; Johns Hopkins University School of Public Health, Johns Hopkins University School of Medicine, and University of Maryland School of Medicine, Baltimore, Maryland; Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana;; University of Illinois at Chicago College of Medicine, Chicago, Illinois; Case Western Reserve University School of Medicine, Cleveland, Ohio; and St. John Hospital/Renaissance Renal Research Institute, Detroit, Michigan. Department of Hepatobiliary Surgery The First Affiliated Hospital of Xi'an Jiaotong University Xi'an China Jiangsu Collaborative Innovation Center of Regional Modern Agriculture and Environmental Protection, Jiangsu Key Laboratory for Eco-Agricultural Biotechnology around Hongze Lake, School of Life Science, Huaiyin Normal University, Huai’an, People’s Republic of China Department of Materials Science, Fudan University, Shanghai 200433, People’s Republic of China State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, CAMS-PUMC, Beijing, China. Department of Geriatrics, Xuan Wu Hospital, Capital Medical University, Beijing, China. Department of Pharmacology, Faculty of Medicine and Dentistry, 9-62 Medical Sciences Building, University of Alberta, Edmonton, AB T6G 2H7, Canada. Division of Cancer Biology and Therapeutics, Departments of Surgery, Biomedical Sciences and Pathology and Laboratory Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA College of Landscape Architecture-Sichuan Agricultural University, Chengdu- Sichuan, China State Key Laboratory of Agricultural Microbiology, Hubei Hongshan Laboratory, The Center of Crop Nanobiotechnology, The Provincial Key Laboratory of Plant Pathology of Hubei Province, College of Plant Science & Technology Huazhong Agricultural University Wuhan China BGI Genomics, BGI-Shenzhen, Building NO.7, BGI Park, No. 21 Hongan 3rd Street, Yantian District, Shenzhen 518083, China Institute of Cardiology, Medical Science College of China Three Gorges University, Yichang, Hubei Province, People's Republic of China. Institute for New Energy Materials and Low Carbon Technologies School of Materials Science and Engineering Tianjin University of Technology Tianjin 300384 China 3Division of Systems Biomedicine and Pharmacology, Leiden Academic Centre for Drug Research (LACDR), Leiden University, Leiden, Zuid-Holland, The Netherlands College of Foreign Languages, Hunan Women’s University, Changsha, Hunan 410004, P. R. China University of Nevada, Reno, School of Community Health Sciences, Reno, Nevada State Key Laboratory of Fine Chemicals; Dalian University of Technology; Dalian; China; Chemical Analysis and Research Center University of Electronic Science and Technology of China School of Computer Science and Engineering, , Chengdu, Sichuan 611731 , China Pollution Ecology and Environmental Engineering, Institute of Applied Ecology, Chinese Academy of Sciences, Shenyang, P.R. China; University of Chinese Academy of Sciences, Beijing, P.R. China Department of Ophthalmology First Hospital of Jilin University Changchun China Reproduction Center Department of Obstetrics and Gynecology Tongji Hospital Huazhong University of Science & Technology Tongji Medical College Wuhan Hubei China National Research Center of Engineering Technology for Utilization of Functional Ingredients from Botanicals Department of Anesthesiology Kunming Medical University First Affiliated Hospital Kunming Yunnan China School of Civil and Environmental Engineering, Nanyang Technological University, Singapore. pg05544456@ntu.edu.sg Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, Pennsylvania; Department of Medical History, Harbin Medical University, Harbin 150081, China. Department of Thoracic Surgery Affiliated Hospital of Jilin Medical University Jilin China 1 Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Ultrasound, 2 Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Gastrointestinal Surgery IV, Peking University Cancer Hospital & Institute, Beijing 100142, China ; 3 State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China ; 4 Department of Cardiovascular and Neurovascular, Guangzhou Medical University, Guangzhou 510182, China ; 5 Department of Oncology, The first Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, China. Departments of Biochemistry and Protein Science, Chemistry, and Molecular Sciences, Infection Discovery, Cancer and Infection Research Area, AstraZeneca R&D Boston, Waltham, Massachusetts 02451 Department of Pediatrics, The Second Affiliated Hospital of Shenzhen University (The People’s Hospital of Baoan Shenzhen), Shenzhen, China Department of Computer Science, University of Illinois, Urbana-Champaign, Urbana, IL, USA Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA () Department of Biophysics, and Department of Neurosurgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China; Department of Radiobiology, School of Radiological Medicine and Public Health, Soochow University, Suzhou, China. College of Chemistry and Molecular Sciences, Key Laboratory of Biomedical Polymers of Ministry of Education, the Institute for Advanced Studies, Hubei Province Key Laboratory of Allergy and Immunology, Wuhan University, Wuhan, Hubei 430072, P. R. China Department of Nephrology, First Affiliated Hospital of Dalian Medical University, Dalian, China Center for X-Mechanics, Zhejiang University, Hangzhou 310027, China School of Resources Engineering, Xi’an University of Architecture and Technology, Xi’an 710055, China Department of Chemical Engineering, University of Washington, Seattle, Washington 98195 Institute of Brain and Gut Research, School of Chinese Medicine, Hong Kong Baptist University , Hong Kong SAR, China Department of Immunology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, People's Republic of China; and Key Laboratory of Medical Molecular Virology of Ministries of Education and Health, School of Basic Medical Sciences, Fudan University, Shanghai 200032, People's Republic of China College of Polymer Science & Engineering; and the State Key Laboratory of Polymer Materials Engineering; Sichuan University; Chengdu 610065; PR China Department of Biostatistics and Epidemiology, School of Medicine, University of Pennsylvania, Philadelphia Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, Tongji Medical College Huazhong University of Science and Technology Hangkong Road 13 430030 Wuhan China; Department of Nutrition and Food Hygiene and MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College Huazhong University of Science and Technology Hangkong Road 13 430030 Wuhan China Department of Materials Science Fudan University Shanghai 200433 P. R. China School of Mechanical and Electronic Engineering, Jingdezhen Ceramic University, Jingdezhen 333403, China MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China Contribution from the Institute of Molecular Biophysics, Florida State University, Tallahassee, Florida 32306, Department of Biological Sciences, Florida State University, Tallahassee, Florida 32306, National High Magnetic Field Laboratory, 1800 East Paul Dirac Drive, Tallahassee, Florida 32310, Department of Chemistry and Biochemistry, Florida State University, Tallahassee, Florida 32306, and School of Computational Science, Florida State University, Tallahassee, Florida 32306 *National Laboratory of Biomacromolecules,; †China-Japan Joint Laboratory of Structural Virology and Immunology, and; ‡Graduate School of the Chinese Academy of Sciences, Institute of Biophysics, Chinese Academy of Sciences, and College of Pharmacy, Jiamusi University, Jiamusi, Heilongjiang 154007, P. R. China; Heilongjiang Provincial Key Laboratory of New Drug Development and Pharmacotoxicological Evaluation, Jiamusi University, Jiamusi 154007, P. R. China State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, P. R. China; Center for DMPK Research of Herbal Medicines, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, P. R. China State Key Laboratory of Advanced Technology for Materials Synthesis and Processing; International School of Materials Science and Engineering; Wuhan University of Technology; Wuhan; China Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA; Center for Clinical Epidemiology and Biostatistics and the Department of Biostatistics and Epidemiology University of Pennsylvania School of Medicine Philadelphia Pennsylvania USA University of Pennsylvania Perelman School of Medicine, Philadelphia, PA. Electronic address: weiyang@mail.med.upenn.edu. Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health Department of Diagnostic Radiology, Unit 1350, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030. Beijing Advanced Innovation Center for Materials Genome Engineering, Beijing Key Laboratory for Science and Application of Functional Molecular and Crystalline Materials, Department of Chemistry and Chemical Engineering, School of Chemistry and Biological Engineering, University of Science and Technology Beijing, Beijing 100083, China Beijing Key Laboratory of Pediatric Hematology Oncology, National Discipline of Pediatrics, Ministry of Education, MOE Key Laboratory of Major Diseases in Children, Hematology Oncology Center, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, China National Forestry and Grassland Administration Key Laboratory of Forest Resources Conservation and Ecological Safety on the Upper Reaches of the Yangtze River, College of Forestry, Sichuan Agricultural University, Chengdu 611130, China Department of Biostatistics, Epidemiology and Informatics, and; Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Ministry of Education Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China College of Chemistry and Molecular Sciences, Department of Hematology of Zhongnan Hospital, Taikang Center for Life and Medical Sciences, Wuhan University, Wuhan, Hubei 430072, People’s Republic of China Key Laboratory of Carcinogensis and Translational Research of Ministry of Education, Department of Ultrasound, Peking University Cancer Hospital & Institute, Beijing 100142, China The State Key Laboratory of Respiratory Disease Guangdong Provincial Key Laboratory of Allergy & Clinical Immunology The Second Affiliated Hospital Guangzhou Medical University Guangzhou China Department of Chemistry and Chemical Biology; Harvard University; Cambridge; USA Department of College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, Daqing 163319, China Center for DMPK Research of Herbal Medicines Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences Beijing China State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing, 100029, China Microbiology Laboratory Lu'an Municipal Center for Disease Control and Prevention Lu'an Anhui China Neonatal and Developmental Medicine, and Department of Hematology, Shengjing Hospital of China Medical University, Shenyang 110004, China Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Department of Nutrition and Food Hygiene and MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; China-DRIs Expert Committee on Other Dietary Ingredients, Sun Yat-sen University, Guangzhou, China Department of Hematology, HangZhou Red Cross Hospital, Hangzhou, Zhejiang, China Department of Clinical Laboratory, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital & Institute, Beijing 100142, China Nanchang University, Nanchang, Jiangxi, People’s Republic of China; University of Nevada, Reno, NV, USA Section of Endocrinology and Diabetes (S.W., F.D.L.), St. Christopher's Hospital for Children, Drexel University College of Medicine, Philadelphia, Pennsylvania 19134; Center for Translational Medicine (S.W., W.Y.), the First Affiliated Hospital of Xi'an Jiaotong University School of Medicine, Xi'an, Shaanxi 710061, People's Republic of China Department of Hepatobiliary Surgery First Affiliated Hospital, Xi'an Jiaotong University Xi'an China CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, People’s Republic of China 4Department of Genetics, Washington University School of Medicine, St. Louis, MO Leibniz Institute for Solid State and Materials Research (IFW Dresden), 01069 Dresden, Germany Department of Ultrasonography, Clinical Oncologic Hospital, Beijing University, Beijing 100036, China Key Lab of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, P.R. China; Key Lab of Analytical Chemistry for Biology and Medicine (Ministry of Education), College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, P.R. China School of Materials Science and Engineering, Shaanxi University of Science & Technology, Xi’an, Shaanxi 710021, China Advanced Manufacturing School, Nanchang University, Nanchang 330031, Jiangxi, China Florida State University Department of Chemistry and Biochemistry, , Tallahassee, Florida 32306; Institute of Molecular Biophysics, , Tallahassee, Florida 32306; and School of Computational Science, , Tallahassee, Florida 32306; Florida State University Department of Chemistry and Biochemistry, , Tallahassee, Florida 32306; Institute of Molecular Biophysics, , Tallahassee, Florida 32306; and School of Computational Science, , Tallahassee, Florida 32306; Florida State University Department of Chemistry and Biochemistry, , Tallahassee, Florida 32306; Institute of Molecular Biophysics, , Tallahassee, Florida 32306; and School of Computational Science, , Tallahassee, Florida 32306 School of Public Health University of Nevada, Reno Reno Nevada USA Department of Pharmacology, Huangpu Hospital of The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, P. R. China. National Key Laboratory of Wheat Improvement, College of Life Science, Shandong Agricultural University, Tai’an 271018, China Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA; Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education & Key Lab of Swine Genetics and Breeding of Ministry of Agriculture and Rural Affairs, Huazhong Agricultural University, Wuhan 430070, China; Guangdong Laboratory of Lingnan Modern Agriculture, Guangzhou 510642, China Key State Laboratory of Chemical Cancer Genomics, Peking University Shenzhen Graduate School, Shenzhen University Town, Xili, Shenzhen 518055, China College of Biological and Pharmaceutical Science China Three Gorges University Yichang P. R. China College of Chemistry, Chemical Engineering and Materials Science, and State Key Laboratory of Radiation Medicine and Protection, Soochow University, Suzhou, Jiangsu 215123, P. R. China Software College, Northeastern University, Shenyang 110819, China Institute of Plant Biology and Zürich-Basel Plant Science Centre, University of Zürich, CH–8008 Zurich, Switzerland (L.B., M.H., E.V., S.V., P.B., U.G., M.D.C.); and CAMBIA, Canberra, Australian Capital Territory 2601, Australia (W.Y., R.A.J.) Department of Biophysics and Department of Neurosurgery, The Fourth Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China Health Science Center at Houston, McGovern Medical School, University of Texas, Houston, TX, USA; College of Resources and Environment, Northeast Agricultural University, Harbin, China School of Life Science, Jiangsu Normal University, No.101, Shanghai Road, Tangshan New Area, 221116, Xuzhou City, Jiangsu Province, PR China Institute of Animal Nutrition; Northeast Agricultural University; Harbin 150030; People's Republic of China Department of Radiation Oncology, Chinese PLA General Hospital, Beijing 100859, China Department of Biophysics, Institute of Neuroscience, NHC and CAMS Key Laboratory of Medical Neurobiology Zhejiang University School of Medicine Hangzhou Zhejiang China The First Affiliated Hospital, Orthopedic Center, Hengyang Medical School, University of South China, Hengyang 421001, Hunan, China Florida State University 1 Department of Chemistry and Biochemistry, , Tallahassee, Florida 32306, USA; Florida State University 2 Institute of Molecular Biophysics, , Tallahassee, Florida 32306, USA and School of Computational Science, , Tallahassee, Florida 32306, USA; Florida State University 2 Institute of Molecular Biophysics, , Tallahassee, Florida 32306, USA and School of Computational Science, , Tallahassee, Florida 32306, USA Beijing National Laboratory for Condensed Matter Physics and Institute of Physics Chinese Academy of Sciences Beijing 100190 China; School of Physical Sciences University of Chinese Academy of Sciences Beijing 100190 China College of Chemistry and Molecular Sciences, Key Laboratory of Biomedical Polymers of Ministry of Education, The Institute for Advanced Studies, Hubei Province Key Laboratory of Allergy and Immunology, Wuhan University; Wuhan; P. R. China Department of Biobank, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Peking University Cancer Hospital and Institute, Beijing 100142, P.R. China Department of Anesthesiology, Duke University Medical Center, Durham, USA Key Laboratory of Molecular Microbiology and Biotechnology (Ministry of Education) and Key Laboratory of Microbial Functional Genomics (Tianjin), College of Life Sciences, Nankai University, Tianjin, China Institute of Molecular Biophysics, Florida State University, Tallahassee, Florida 32306, United States; Department of Chemistry and Biochemistry, Florida State University, Tallahassee, Florida 32306, United States Tianjin Medical Device Evaluation and Inspection Center Tianjin China Wenzhou Institute University of Chinese Academy of Sciences No.1 Jinlian Road, Longwan District Wenzhou 325001 China Department of Thoracic Surgery, Shengjing Hospital of China Medical University, Shenyang 110004, China; Department of Clinical Laboratory, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, Zhejiang 310014, PRChina University of Cambridge Metabolic Research Laboratories, Wellcome Trust–Medical Research Council Institute of Metabolic Science, Cambridge CB2 0QQ, United Kingdom Environmental Sciences and Health Graduate Program, University of Nevada, Reno, NV 89557, USA; School of Community Health Sciences, University of Nevada, Reno, NV 89557, USA Department of Pathology School of Basic Medical Sciences Department of Pathology Nanfang Hospital, and Guangdong Provincial Key Laboratory of Molecular Oncologic Pathology Southern Medical University Guangzhou 510515 China Department of Geriatric Endocrinology The First Affiliated Hospital of Guangxi Medical University Nanning China Department of Infectious Diseases Shengjing Hospital, Affiliated Hospital of China Medical University Shenyang China Molecular and Cellular Developmental Biology Laboratory, Harbin Institute of Technology, Harbin 150001, China. dahaizhu@hotmail.com Infection Bioscience, AstraZeneca R&D Boston, Waltham, Massachusetts, USA Department of Neurology, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, China MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China Department of Pulmonary and Critical Care Medicine, Xiangya Hospital, Central South University, Changsha 410008, China. Department of Hematology, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110022, P.R. China College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325035, China Department of Pediatrics, Neonatal and Developmental Medicine, Stanford University School of Medicine, Stanford, CA. School of Public Health, University of Nevada, Reno, Reno, Nevada, USA Florida State University 1 Institute of Molecular Biophysics, , Tallahassee, Florida 32306, USA; Florida State University 4 Department of Chemistry and Biochemistry, , Tallahassee, Florida 32306, USA; Nankai University 5 College of Life Science, , Tianjin 300071, P. R. China State Key Laboratory of Ophthalmology Zhongshan Ophthalmic Center Sun Yat‐sen University Guangzhou China Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China Department of Pathology, School of Basic Medical Sciences & Nanfang Hospital Southern Medical University Guangzhou PR China Centre for Bioengineering and Biotechnology China University of Petroleum (East China) Changjiang West Road Qingdao 266580 P. R. China Department of Medical Genetics Capital Institute of Pediatrics Beijing China Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China. ywonline@163.com Department of Stomatology, Sijing Hospital. Shanghai 201601, China. E-mail:66806761@qq.com. Institutes of Physical Science and Information Technology; Hefei 230601; P. R. China Jan M. Eberth, Arnold School of Public Health, University of South Carolina, Columbia, SC; and Ying Xu, Grace L. Smith, Yu Shen, Jing Jiang, Thomas A. Buchholz, Kelly K. Hunt, Dalliah M. Black, Sharon H. Giordano, Gary J. Whitman, Wei Yang, Chan Shen, Linda Elting, and Benjamin D. Smith, The University of Texas MD Anderson Cancer Center, Houston, TX. Departments of Neurosurgery and Center for Pharmacoepidemiology Research and Training, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania Department of Hepatopancreatobiliary Surgery, China-Japan Union Hospital of Jilin University Jilin, China. Department of Physiology II, Kanazawa Medical University, Uchinada, Japan.; Department of Infectious Disease, Shengjing Hospital of China Medical University, Shenyang, China. Division of Neonatal and Developmental Medicine, Department of Pediatrics Stanford University School of Medicine Palo Alto California McDonnell Genome Institute, Genome Technology Access Center, Washington University in St Louis School of Medicine, St. Louis, Missouri, United States Xiamen Xian Yue Hospital, Xiamen, Fujian, China. Fellow in Hematopathology, Department of Pathology, Case Western Reserve University, Cleveland, OH, USA. Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Department of Nutrition and Food Hygiene and MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China Beijing Institute of Smart Energy, Beijing 102209, China. Email: 19630100@163.com School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou City, Zhejiang Province, China The Institute of Advanced Studies, and Key Laboratory of Biomedical Polymers-Ministry of Education, College of Chemistry and Molecular Sciences, Wuhan University, 40072 Wuhan, P.R. China Department of Molecular and Systems Biology, Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, NH 1 Division of Pharmaceutics, The University of Texas at Austin, 1 University Station A1920, Austin, Texas 78712 Jilin Provincial Key Laboratory on Molecular and Chemical Genetic Second Hospital of Jilin University Changchun China Department of Pediatrics, Division of Neonatal and Developmental Medicine, Stanford University School of Medicine Palo Alto California College of Polymer Science and Engineering Sichuan University Chengdu 610065 China College of Life Sciences, Liaoning University, Shenyang 110036, China. Contribution from the Department of Chemistry, Center of Drug Design, Georgia State University, Atlanta, Georgia 30303, and Department of Animal and Dairy Sciences, Auburn University, Auburn, Alabama 36849, and Medical Center, Department of Biochemistry, Duke University, Durham, North Carolina 27710, and Department of Geology, Georgia State University, Atlanta, Georgia 30303 Department of Pediatrics Stanford University School of Medicine Stanford California Guangzhou Bay Area Institute of Biomedicine, Guangdong Lewwin Pharmaceutical Research Institute Co., Ltd., Guangdong Provincial Key Laboratory of Drug Non-Clinical Evaluation and Research, Guangzhou, China.; Division of Life Science and State Key Lab of Molecular Neuroscience, The Hong Kong University of Science and Technology, Hong Kong, China. Department of Psychology, Changchun Sixth Hospital, Changchun, China. 1 Northeast Agricultural University College of Veterinary Medicine 59 Mucai Street, Xiangfang District 150030 Harbin China Department of Hepatobiliary Surgery The First Affiliated Hospital of Xi'an Jiaotong University Xi'an Shaanxi China The Key Laboratory of Cardiovascular Remodeling and Function Research of Chinese Ministry of Education and Chinese Ministry of Health, The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Department of Cardiology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan 250012, China. State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of Technology Wuhan 430070 Hubei P. R. China College of Polymer Science and Engineering and ‡State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, Sichuan, China State Key Laboratory of Water Environment Simulation School of Environment Beijing Normal University Beijing China; Yellow River Estuary Wetland Ecosystem Observation and Research Station Ministry of Education Shandong China Department of Engineering Mechanics, Zhejiang University, Hangzhou 310027, China. Department of General Surgery, Affiliated Tumor Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, Henan 450008, P.R. China Contribution from the Departments of Chemistry and Biology, Center for Drug Design and Biotechnology, Georgia State University, Atlanta, Georgia 30303, Department of Chemistry, University of Georgia, Athens, Georgia 30602-2556, Department of Biochemistry, Medical Center, Duke University, Durham, North Carolina 27710, and Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, OX1, 3RE, U.K. Department of Nephrology, Chinese Academy of Medical Science & Peking Union Medical College Hospital, Beijing, China Department of Physiology, Key Laboratory of Cellular Physiology, Ministry of Education; Shanxi Medical University; Taiyuan, Shanxi; 030001; China State Key Laboratory of Advanced Technology for Materials Synthesis and Processing; International School of Materials Science and Engineering; Wuhan University of Technology; Wuhan 430070; China Jilin Provincial Key Laboratory on Molecular and Chemical Genetic, The Second Hospital of Jilin University, Changchun, China College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, Daqing, China Center for Drug Non-clinical Research and Evaluation of Pharmaceutical Industrial Research Institute in Guangzhou Department of clinical laboratory, The Affiliated Hospital of Xizang Minzu University, Xianyang, Shaanxi 712082, PR China Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, Maryland 21201, United States Jiangsu Key Laboratory for Eco-Agricultural Biotechnology around Hongze Lake/Jiangsu Collaborative Innovation Center of Regional Modern Agriculture and Environmental Protection, Huaiyin Normal University, Huai’an, China Department of Neurosurgery, Beijing Children's Hospital, Capital Medical University National Center for Children's Health China China National GeneBank, Beijing Genomics Institute (BGI)–Shenzhen, Shenzhen, 518083, China. Hematology Center, Beijing Key Laboratory of Pediatric Hematology Oncology, National Key Discipline of Pediatrics (Capital Medical University), Key Laboratory of Major Diseases in Children, Ministry of Education, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, People’s Republic of China Department of Nutrition and Food Hygiene Hubei Key Laboratory of Food Technology School of Public Health Tongji Medical College Huazhong University of Science and Technology 13 Hangkong Road Wuhan 430030 China Department of General Practice, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, China. Department of Hepatobiliary Surgery, First Affiliated Hospital, Medical College, Xi'an Jiaotong University, Xi'an 710061, China. *Corresponding author, E-mail: tks0912@foxmail.com. Jilin Provincial Key Laboratory on Molecular and Chemical Genetic, Second Hospital of Jilin University, Changchun 130041, China Oncology f Diagnostic Radiology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA; h Morgan Welch Inflammatory Breast Cancer Research Program and Clinic, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA Department of Physiology, School of Basic Medical Sciences, Harbin Medical University, Harbin 150081, China Analysis Center of College of Resources and Environmental Sciences,, Nanjing Agricultural University, Nanjing 210095, Jiangsu, China State Key Laboratory of Hydraulics and Mountain River Engineering, College of Water Resource & Hydropower, Sichuan University, Chengdu 610065, P. R. China School of Pharmacy; Shenyang Pharmaceutical University; Shenyang; PR China Key Laboratory of Green Chemistry & Technology Ministry of Education College of Chemistry Sichuan University Chengdu 610064 China Department of Respiratory Disease, Peking University Third Hospital, Beijing 100083, China. Carl R. Woese Institute for Genomic Biology University of Illinois at Urbana‐Champaign Urbana Illinois; Department of Computer Science University of Illinois at Urbana‐Champaign Urbana Illinois Guangdong Research Center on Reproductive Control and Breeding Technology of Indigenous Valuable Fish Species, Fisheries College, Guangdong Ocean University, Zhanjiang, China; Guangdong Provincial Key Laboratory of Marine Biotechnology, Shantou University, Guangdong, China Department of Obstetrics and Gynecology, First Affiliated Hospital of Jiamusi University, Jiamusi, Heilongjiang, China Hebei Key Laboratory of New Functional Materials, School of Material Science and Engineering, Hebei University of Technology, No. 5340, Xiping Road, Beichen District, Tianjin 300401, China Laboratory of Molecular Biology, NIDDK, NIH, Bethesda, MD, USA College of Polymer Science and Engineering State Key Laboratory of Polymer Materials Engineering Sichuan University Chengdu 610065 China School of Physical Science and Technology, MOE Key Laboratory on Luminescence and Real-Time Analysis, Southwest University, Chongqing 400715, China Department of Cardiology, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, China State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Wuhan 430070, China Institute of Biomedical Engineering the Second Clinical Medical College (Shenzhen People's Hospital) of Jinan University Shenzhen Guangdong 518020 P. R. China Beijing National Laboratory for Condensed Matter Physics and Institute of Physics, Chinese Academy of Sciences, Beijing 100190, China; Laboratoire Pierre Aigrain, Ecole Normale Supérieure-PSL Research University, CNRS, Université Pierre et Marie Curie-Sorbonne Universités, Université Paris Diderot-Sorbonne Paris Cité, 24 rue Lhomond, 75231 Paris Cedex 05, France Department of Gastroenterology, Taizhou Hospital, Linhai, Zhejiang Province, China Key Laboratory of Multifunctional Nanomaterials and Smart Systems Advanced Materials Division Suzhou Institute of Nano‐Tech and Nano‐Bionics Chinese Academy of Sciences Suzhou 215123 China Warshel Institute for Computational Biology, School of Science and Engineering, The Chinese University of Hong Kong, Shenzhen, China; School of Biotechnology, University of Science and Technology of China, Hefei, China; Biomedicine Discovery Institute, Monash University, Melbourne, Australia North University of China Key Laboratory of Instrumentation Science and Dynamic Measurement, Ministry of Education, , Taiyuan 030051, People’s Republic of China and National Key Laboratory for Electronic Measurement Technology, School of Instrument and Electronics, , Taiyuan 030051, People’s Republic of China; North University of China Key Laboratory of Instrumentation Science and Dynamic Measurement, Ministry of Education, , Taiyuan 030051, People’s Republic of China and National Key Laboratory for Electronic Measurement Technology, School of Instrument and Electronics, , Taiyuan 030051, People’s Republic of China College of Resources and Environment, Hunan Agricultural University, Changsha 410128, China. 893315780@qq.com School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, China Department of Chemistry and Biochemistry Florida State University Tallahassee Florida 32306; Institute of Molecular Biophysics Florida State University Tallahassee Florida 32306 National Institute of Biological Sciences, Zhongguancun Life Science Park, Beijing 102206, China (J.L., P.D., X.H., W.Y., Y.Z.) The State Key Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai 200031, China. College of Chemistry, Chemical Engineering and Materials Science, Soochow University; Faculty of Food Science and Technology, Suzhou Polytechnical Institute of Agriculture 1Department of Pharmacology and Toxicology, Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire. Beijing System Design Institute of Electro-Mechanic Engineering, Beijing 100854, China School of Pharmacy, Nanjing Medical University, Nanjing, Jiangsu 211166, China Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, Philadelphia, Pennsylvania, USA. NHC Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China Department of Hepatobiliary Surgery, First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China Hebei Key Laboratory of New Functional Materials, School of Material Science and Engineering, Hebei University of Technology, No. 5340, Xiping Road, Tianjin 300401, China State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116024, People’s Republic of China; Chemical Analysis and Research Center, Dalian University of Technology, Dalian 116024, People’s Republic of China Department of Nutrition and Food Hygiene Hubei Key Laboratory of Food Nutrition and Safety Tongji Medical College Huazhong University of Science and Technology Wuhan China; Department of Nutrition and Food Hygiene MOE Key Lab of Environment and Health School of Public Health Tongji Medical College Huazhong University of Science and Technology Wuhan China Molecular Sciences, AstraZeneca R&D Boston, Waltham, Massachusetts 02451 Department of Biostatistics and Epidemiology, University of Pennsylvania Perelman School of Medicine, Philadelphia Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA. Department of Medical History, Harbin Medical University, Harbin, 150081, China. 2Department of Genetics, Washington University School of Medicine, St. Louis, MO 1Division of Endocrinology, Department of Internal Medicine School of Pharmacy, Memorial University of Newfoundland, St. John's, NL, Canada A1B 3V6 Department of Neurology, The Second Hospital of Jilin University, Changchun, Jilin 130041, P.R. China Center for DMPK Research of Herbal Medicines, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China School of Food Science and Technology in Jiangnan University Wuxi Jiangsu 214122 China The Second Hospital of Jilin University Jilin China Department of Urology, The Third Affiliated Hospital of Naval Military Medical University (Eastern Hepatobiliary Surgery Hospital), Shanghai 201805, China Department of Biostatistics and Epidemiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. Departments of cPathology and; Immune Disease Institute and Program in Cellular and Molecular Medicine, Children's Hospital Boston, Boston, MA 02115 Clinical Laboratory Center, The Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325027, China. Department of Ultrasound, Sichuan Cancer Hospital Department of Chemistry; Northeast Normal University; Changchun 130024; China Department of Engineering Mechanics, Zhejiang University, Hangzhou 310027, China Department of Physiology, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada.; Department of Pharmacology, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada.; Department of Pathology, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada.; Departments of Neuroscience, Pharmacology and Molecular Sciences and Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.; Department of Biology, Lakehead University, Thunder Bay, ON P7B 5E1, Canada. School of Public Health, University of Nevada, Reno, USA Department of Neurological Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Shandong University, Jinan, Shandong 250021, P.R. China Beijing National Laboratory for Condensed Matter Physics and Institute of Physics, Chinese Academy of Sciences , Beijing 100190 , China; School of Physical Sciences, University of Chinese Academy of Sciences , Beijing 100190 , China Department of Nephrology, Liaoning Translational Medicine Center of Nephrology, First Affiliated Hospital of Dalian Medical University, Dalian, China Contribution from the Institute of Polymer Optoelectronic Materials and Devices, Key Laboratory of Specially Functional Materials and Advanced Manufacturing Technology, South China University of Technology, Guangzhou 510640, China Department of Laboratory Diagnostics, The First Affiliated Hospital of Harbin Medical University, Harbin, P.R. China. Tianjin Key Laboratory of Molecular Drug Research, Tianjin International Joint Academy of Biomedicine, Tianjin, China Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110; Undergraduate, Department of Gastroenterology, Xiantao First People’s Hospital of Yangtze University, Xiantao, China Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032. State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of Technology Wuhan 430070 P. R. China Center for X-Mechanics, Department of Engineering Mechanics, Zhejiang University, Hangzhou 310027, P. R. China. Perelman School of Medicine, University of Pennsylvania, PA, 19104 Department of Pathophysiology, School of Basic Medical Sciences Harbin Medical University Harbin China; School of Public Health Qiqihar Medical University Qiqihar China Warshel Institute for Computational Biology School of Science and Engineering The Chinese University of Hong Kong Shenzhen China The Second Department of Respiration, Baoding No.1 Central Hospital, HeBei, China 1The Urological Diseases Research Center, Children's Hospital Boston; Departments of; 2Surgery and Infection and Immunity Program, Department of Microbiology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria 3800, Australia Department of Laboratory Diagnostics First Affiliated Hospital of Harbin Medical University Harbin Heilongjiang People's Republic of China State Key Laboratory of Artificial Microstructure and Mesoscopic Physics, School of Physics, Peking University, Beijing 100871, P. R. China Laboratories of Molecular Biology and Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, and Laboratory of Genomic Integrity, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 State Key Laboratory for Artificial Microstructure and Microscopic Physics, School of Physics, Peking University, Beijing 100871, China Jilin Provincial Key Laboratory for Molecular and Chemical Genetics, The Second Hospital of Jilin University, Changchun 130041, P.R. China; Department of Neurology, The Second Hospital of Jilin University, Changchun 130041, P.R. China School of Science, Linyi Normal University, Linyi Shandong 276005, P.R. China From the Multidisciplinary Neuroprotection Laboratories, Department of Anesthesiology, Duke University Medical Center, Durham, NC (M.J., S.Y., Z.Y., H.S., Y.L., S.L., D.S.W., W.P., W.Y.); Department of Anesthesiology (M.J.) and Department of Critical Care Medicine (Z.Y.), Renmin Hospital of Wuhan University, China; Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Collaborative Innovation Center of Neuroregeneration, Nantong University, China (S.Y.); and Department of... Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine University of Pennsylvania Philadelphia U.S.A. Department of Critical Care Medicine, The First Affiliated Hospital of Harbin Medical University, Harbin Medical University, Harbin, China. Department of Radiation Oncology, The First Medical Center of People’s Liberation Army General Hospital, Beijing, China; Department of Spleen and Stomach and Hepatology Kunshan Hospital of Traditional Chinese Medicine Kunshan Jiangsu China Department of Gastroenterology, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang Department of Integrative Medicine and Neurobiology Institutes of Integrative Medicine, School of Basic Medical Sciences, Institutes of Brain Science, Brain Science Collaborative Innovation Center, State Key Laboratory of Medical Neurobiology, Fudan University Shanghai People's Republic of China PKU-IDG/McGovern Institute for Brain Research, Peking-Tsinghua Center for Life Sciences, Beijing Advanced Innovation Center for Genomics, Peking University School of Life Sciences , Beijing , China; Chinese Institute for Brain Research , Beijing , China Department of Respiratory Medicine, Third Hospital of Peking University, Beijing 100083, China. College of Chemistry and Molecular Sciences, Key Laboratory of Biomedical Polymers of Ministry of Education, Wuhan University, Wuhan, 430072 Hubei, China Department of Traditional Chinese Medicine Beijing Obstetrics and Gynecology Hospital, Capital Medical University Beijing China The State Key Laboratory of Electroanalytic Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China School of Community Health Sciences, University of Nevada, Reno, New Brunswick, New Jersey Department of Chemical Engineering, University of Washington, Seattle, Washington 98195, United States State Key Laboratory of Heavy Oil Processing College of Chemical Engineering China University of Petroleum East China–Qingdao Campus No. 66, West Changjiang Road Huangdao District P. R. China Department of Hepatobiliary Surgery, First Hospital of Xian Jiaotong University , Xian , People’s Republic of China Genome Technology Access Center, Washington University, St. Louis, MO; Key Laboratory for the Physics and Chemistry of Nanodevices and Department of Electronics, Peking University, Beijing 100871, China Tianjin Key Laboratory of Aqua-ecology and Aquaculture, College of Basic Science, Tianjin Agricultural University Key Laboratory for the Physics and Chemistry of Nanodevices, School of Electronics, Peking University, Beijing 100871, China 1 MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China Department of Biophysic, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, P.R. China CAS Key Laboratory of Infection and Immunity, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China Department of Anesthesiology, First Affiliated Hospital of Kunming Medical University, Kunming 650032, Yunnan, China Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania; Department of Chemistry and Biochemistry, Florida State University, Tallahassee, Florida 32306, United States; Institute of Molecular Biophysics, Florida State University, Tallahassee, Florida 32306, United States Department of Clinical Laboratory Zhejiang Provincial People's Hospital Hangzhou China National Key Laboratory for Innovation and Transformation of Luobing Theory The Key Laboratory of Cardiovascular Remodeling and Function Research Chinese Ministry of Education Chinese National Health Commission and Chinese Academy of Medical Sciences Department of Cardiology Qilu Hospital of Shandong University Jinan 250012 China Department of Chemical Engineering, University of Washington, Box 351750, Seattle, Washington 98195, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, P.R.China Department of Microbiology, School of Basic Medical Sciences, Capital Medical University, Beijing, People’s Republic of China Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College Huazhong University of Science and Technology Wuhan China State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen 361102, Fujian, China Jilin Provincial Key Laboratory on Molecular and Chemical Genetics The Second Hospital of Jilin University Changchun People's Republic of China Department of Respiratory Medicine, Peking University Third Hospital, Beijing 100191, China. Department of Chemistry and Biochemistry, Institute of Molecular Biophysics, and School of Computational Science, Florida State University, Tallahassee, Florida 32306, Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, and Department of Chemistry, The Ohio State University, Columbus, Ohio 43210 Department of Pediatrics, Division of Neonatology Stanford University Stanford CA Microbiome Medicine Center,Zhujiang Hospital, Southern Medical University,Guangzhou,China; Department of Pathology,Southern Medical University,Guangzhou,China College of Land Science and Technology, China Agricultural University, Beijing, People’s Republic of China Harbin Medical University Cancer Hospital, 150 Haping Road, Harbin 150081, China The State Key Laboratories for Agrobiotechnology, Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, National Animal Transmissible Spongiform Encephalopathy Laboratory, College of Veterinary Medicine, China Agricultural University, Beijing, China Department of Traditional Chinese Medicine, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, PR China School of Biomedical Sciences, University of Leeds, Leeds LS2 9JT, U.K. Department of Surgery Division of Cancer Biology and Therapeutics Cedars‐Sinai Medical Center Los Angeles CA USA; Department of Biomedical Sciences Division of Cancer Biology and Therapeutics Cedars‐Sinai Medical Center Los Angeles CA USA; Samuel Oschin Comprehensive Cancer Institute Division of Cancer Biology and Therapeutics Cedars‐Sinai Medical Center Los Angeles CA USA; Department of Medicine David Geffen School of Medicine University of California Los Angeles Los Angeles CA USA Key Laboratory for Deep Processing of Major Grain and Oil (Wuhan Polytechnic University) of Ministry of Education in China, College of Food Science and Engineering, Wuhan Polytechnic University, Wuhan, P. R. China Harvard University Department of Chemistry and Chemical Biology, , Cambridge, Massachusetts 02138 College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, Jiangsu, 215123, P. R. China Department of Gastrointestinal Surgery College of Life Sciences Zhongnan Hospital of Wuhan University Wuhan 430071 China; Department of Pulmonary and Critical Care Medicine Zhongnan Hospital of Wuhan University Wuhan 430071 China; Department of Immunology Medical Research Institute and Frontier Science Center for Immunology and Metabolism Wuhan University Wuhan 430071 China Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang 110016, China Beijing National Laboratory for Condensed Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing 100190, China; Key Laboratory for Renewable Energy, Chinese Academy of Science, Beijing Key Laboratory for New Energy Materials and Devices, Beijing 100190, China Department of Imaging, Binzhou Medical University, Yantai 264003, Shandong, PR China Hubei Key Laboratory of Food Nutrition and Safety, School of Public Health Tongji Medical College, Huazhong University of Science and Technology 13 Hangkong Road Wuhan 430030 China; Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China Department of Biostatistics and Epidemiology, Center for Clinical Epidemiology and Biostatistics University of Pennsylvania Perelman School of Medicine Philadelphia PA U.S.A. Faculty of Food Science and Technology, Suzhou Polytechnic Institute of Agriculture, Suzhou 215008, China State Key Laboratory of Fluid Power & Mechatronic System, Key Laboratory of Soft Machines and Smart Devices of Zhejiang Province, Center for X-Mechanics, Department of Engineering Mechanics, Zhejiang University, Hangzhou 310027, China School of Geographical Science, Taiyuan Normal University, Jinzhong 030619, China. State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian, Liaoning 116024, China Reproductive Medicine Center, Tongji Hospital, Tongji Medicine College, Huazhong University of Science and Technology, Wuhan, Hubei, China National Animal Transmissible Spongiform Encephalopathy Laboratory and Key Laboratory of Animal Epidemiology and Zoonosis of Ministry of Agriculture College of Veterinary Medicine and State Key Laboratory of Agrobiotechnology China Agricultural University Beijing China; Hebei Institute of Animal Science and Veterinary Medicine Baoding China School of Environment Beijing Normal University Beijing China School of Community Health Sciences, University of Nevada, Reno, Nevada Beijing Key Laboratory of Functional Food from Plant Resources, College of Food Science & Nutritional Engineering, China Agricultural University, Beijing 100083, People’s Republic of China Laboratory of Molecular Biology, NIDDK, National Institutes of Health, Bethesda, MD, United States. Electronic address: wei.yang@nih.gov. School of Pharmaceutics Science, Wenzhou Medical College, Wenzhou City, Zhejiang Province, China Department of Human Genetics, University of Utah, Salt Lake City, Utah 84112 Bioelectromagnetic Lab, Institute of Electrical Engineering, Chinese Academy of Sciences, Beijing 100080, China. Food Chemistry and Food Development, Department of Biochemistry, §Instrument Centre, Department of Chemistry, and #The Kevo Subarctic Research Institute, University of Turku, FI-20014 Turku, Finland Department of Anesthesiology Duke University Durham North Carolina Key Laboratory of Integrated Pest Management on Crops in Northeast, Ministry of Agriculture, Institute of Plant Protection, Jilin Academy of Agricultural Sciences , Gongzhuling 136100 , China Global Energy Interconnection Research Institute, State Key Laboratory of Advanced Transmission Technology, Beijing 102211, P. R. China CBR Institute for Biomedical Research and Department of Pathology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115 Beijing Key Laboratory of Functional Food from Plant Resources, College of Food Science & Nutritional Engineering, China Agricultural University, P.O. Box 112, No. 17 Qinghua East Road, Beijing 100083, People’s Republic of China Mount Sinai School of Medicine, New York, New York. Center for X-Mechanics, Key Laboratory of Soft Machines and Smart Devices of Zhejiang Province and Department of Engineering Mechanics, Zhejiang University, Hangzhou 310027, China Soft Matter Research Center Key Laboratory of Soft Machines and Smart Devices of Zhejiang Province Department of Engineering Mechanics Zhejiang University Hangzhou Zhejiang 310027 P. R. China Department of Breast Imaging, The University of Texas MD Anderson Cancer Center, Houston, Texas Second Department of Hematology,Shengjing Hospital of China Medical University,Shenyang 110022, Liaoning Province, China. E-mail:yangw@sj-hospital.org. Department of Oral and Maxillofacial Surgery, The Second Hospital of Hebei Medical University, Shijiazhuang, China. Department of Biophysics, Zhejiang University School of Medicine, Hangzhou 310058, P. R. China State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, School of Materials Science and Engineering, Wuhan University of Technology, Wuhan 430070, People’s Republic of China Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia Radiotherapy Department, First Medical Center, General Hospital of Chinese People's Liberation Army, Beijing, 100853. Medical College of Qinghai University #16 Kunlun Road Xining 810001 P. R. China Department of Ultrasound, Peking University School of Oncology, 52 Fu-cheng Rd., Hai-dian District, Beijing 100036, People's Republic of China. A. Junaid, W. Yang, A. Mashaghi, T. Hankemeier Division of Systems Biomedicine and Pharmacology Leiden Academic Centre for Drug Research Leiden University Leiden 2333 CC The Netherlands Department of Pathology, Allen Hospital, Unitypoint Clinic, Waterloo, Iowa, United States. Department of Pediatrics Division of Neonatology Stanford University School of Medicine Stanford California Beijing Institute of Smart Energy, Beijing 102299, China Department of Hand Microsurgery, The First Affiliated Hospital, University of South China, Hengyang, Hunan 421001, P.R. China State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China From the Department of Cell, Developmental and Integrative Biology (Z.Y., W.Y., H.W., E.N.B., H.Q.), Department of Neurology (M.N.D., D.G.S.), and Department of Biostatistics (G.R.C.), University of Alabama at Birmingham. Department of Chemistry, Northeast Normal University, Changchun 130024, China National Clinical Research Center for Infectious Diseases, Shenzhen Third People's Hospital, Shenzhen, 518112, China Psychological Counselling Centre, Xijing University, Xi'an, China Department of Proctology, the First Affiliated Hospital of Guangxi College of Chinese Medicine, Nanning 530000, China. The Center for Drug Research and Development, Guangdong Pharmaceutical University, Guangzhou, China; Department of Biophysics, Institute of Neuroscience, NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China McKusick-Zhang Center for Genetic Medicine, State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. From the Department of Anesthesiology (W.Y., H.S., L.W., P.M., X.L., W.P.), Proteomics Core Facility (J.W.T., M.A.M.), and Department of Neurobiology (S.Z.), Duke University Medical Center, Durham, NC; and Department of Neurosurgery, The Fifth Central Hospital of Tianjin, Tianjin, China (X.L.). State Key Laboratory of Agricultural Microbiology, College of Plant Science and Technology, Huazhong Agricultural University, Wuhan, PR China Department of Pediatrics Division of Neonatal and Developmental Medicine Stanford University School of Medicine Stanford California USA Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA *CAS Key Laboratory of Infection and Immunity, Center for Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China;; †Graduate School of the Chinese Academy of Sciences, Beijing 100101, China; Department of Biomedical Engineering and ‡Department of Physics, The University of Texas at Austin, Austin, Texas 78712, United States; Institute of Molecular Biophysics and ∥Department of Chemistry and Biochemistry, Florida State University, Tallahassee, Florida 32306, United States Jilin Provincial Key Laboratory on Molecular and Chemical Genetic, The Second Hospital of Jilin University, Changchun 130041, P. R. China Division of Neonatology and Developmental Medicine, Department of Pediatrics Stanford University School of Medicine Stanford California USA |
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