author/MD5_a8883c39648b363852faa57b084c3654

http://rdf.ncbi.nlm.nih.gov/pubchem/author/MD5_a8883c39648b363852faa57b084c3654

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Predicate	Object
family-name	Li Sun Sun
name	Li Sun
given-name	Li
organization-name	Department of Respiratory Medicine, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China Molecular Infectious Diseases Group, University of Oxford, Department of Paediatrics, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DS, UK 1Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Qingdao, PR China; 2Laboratory for Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, Qingdao, PR China From the Sino-German Laboratory for Molecular Medicine and Center for Molecular Cardiology, Fuwai Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences (L.S., Z.L., H.Z., Z. Zhang, W.W., R.H.), Beijing, China; First Teaching Hospital, Xi’an Jiao Tong University (A.M.), Xi’an City, China; Department of Cardiology, Tongji Hospital (Y.L.) and Cardiovascular Institute, Union Hospital (D.W.), Huazhong University of Science and Technology, Wuhan City, China; Tianjin Cardiovascular... School of Life Science, Shanghai University, Shanghai, China Department of Hernia and Abdominal Wall Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China Department of Oncology Nanfang Hospital, Southern Medical University Guangzhou 510515 China Siping Central People's Hospital Siping China Department of Rheumatology, Children's Hospital of Fudan University, Shanghai, China Department of Polymer Materials Science and Engineering; South China University of Technology; Guangzhou 510640 China Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, Washington 98195, United States College of Chemistry and Molecular Sciences, National Demonstration Center for Experimental Chemistry Education (Wuhan University), Wuhan University, Wuhan, 430072, People’s Republic of China Department of Breast Surgery, The Affiliated Changzhou No. 2 People’s Hospital of Nanjing Medical University, Changzhou 213000, Jiangsu Province, China Department of Cardiology, The First Affiliated Hospital, Harbin Medical University, Harbin, 150001, Heilongjiang Province, P. R. China Key Laboratory of Functional Protein Research of Guangdong Higher Education Institutes, Institute of Life and Health Engineering, College of Life Science and Technology, Jinan University, Guangzhou 510632, China Department of Oncology, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, Hubei Province, China Anesthesia and Operation Centre; Chinese PLA General Hospital; Beijing 410078; P. R. China Department of Radiology, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China MOE Key Laboratory of Cluster Science; School of Chemistry and Chemical Engineering; Beijing Institute of Technology; Beijing 100081; China Department of Rheumatology and Immunology The First Affiliated Hospital of Wenzhou Medical University Wenzhou China Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China CAS Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai 200031, China Department of Physics, Emory University, Atlanta, Georgia 30322 Laboratory for Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, Qingdao, PR China; Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Qingdao, PR China Department of Elderly Respiratory Medicine, Shaanxi Provincial People's Hospital, Xi'an, Shaanxi 710068, P.R. China 1Department of Thoracic/Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas. Department of Digestive Surgery, Honghui Hospital, Xi'an Jiaotong University , Xi'an, Shaanxi, People's Republic of China College of Information Science and Engineering, Shandong Agricultural University, China Department of Burns, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, China. Department of Respiratory Medicine; First Affiliated Hospital of Anhui Medical University; Hefei China Department of Neurology The First Affiliated Hospital of Nanjing Medical University Nanjing China Department of Chemical and Environmental Engineering, University of California, Riverside, California 92521, Department of Mechanical Engineering, University of Houston, Houston, Texas 77057, and Department of Chemical and Biomolecular Engineering, Tulane University, New Orleans, Louisiana 70118 Departments of Pediatrics and Medicine (M.I.N., T.Y., C.P., A.K., M.Y., S.-M.K., L.S., M.Z.), Mt Sinai School of Medicine, New York, New York 10029 College of Horticulture and Landscape Architecture, Henan Institute of Science and Technology, Xinxiang, Henan, PR China; Henan Provincial Research Center for Horticultural Plant Resource Utilization and Germplasm Innovation Engineering, Henan, Xinxiang, China School of Physics, State Key Laboratory of Crystal Materials, School of Microelectronics, Shandong University, Jinan 250100, China Murad Research Institute for Modernized Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China. State Key Laboratory of Natural Medicines; Department of Organic Chemistry; China Pharmaceutical University; Nanjing; P. R. China Department of Obstetrics and Gynecology, Yantai Hospital of Traditional Chinese Medicine, Yantai, China Jiangsu Key laboratory of Drug Screening, China Pharmaceutical University, Nanjing, China The Mount Sinai Bone Program, Department of Medicine, Mount Sinai School of Medicine, NY 10029; Department of Library, Foshan Women and Children Hospital, Foshan, Guangdong, China Department of Histology and Embryology, College of Basic Medicine, Guilin Medical University Guilin, Guangxi 541001, P.R. China. M. Mohammadi, B. K. Yeh, J. Schlessinger, Department of Pharmacology, New York University Medical Center, New York, NY 10016, USA.; G. McMahon, L. Sun, C. Tang, P. Hirth, SUGEN, Redwood City, CA 94063, USA.; S. R. Hubbard, Skirball Institute of Biomolecular Medicine and Department of Pharmacology, New York University Medical Center, New York, NY 10016, USA. Department of Medicine, The Mount Sinai Bone Program Icahn School of Medicine at Mount Sinai New York New York NHC Key Laboratory of Birth Defects Research, Prevention and Treatment, Hunan Provincial Maternal and Child Health Care Hospital, Changsha, PR China. Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Center for Ocean Mega-Science, Chinese Academy of Sciences, Qingdao 266071, China;; †Laboratory for Marine Biology and Biotechnology, Pilot National Laboratory for Marine Science and Technology, Qingdao 266237, China; and Departments of Medicine, Pediatrics, and Chemical and Structural Biology, and the Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029; School of Engineering and Applied Sciences, Harvard University, 9 Oxford Street, Cambridge, Massachusetts 02138, United States Clinical Laboratory, Jiaxing No. 1 Hospital, Jiaxing, Zhejiang 314001, P.R. China Department of Gynecological Oncology, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China. School of Life Science, Liaoning Normal University, Dalian 116081, China Department of Ophthalmology Huashan Hospital Affiliated to Fudan University Shanghai China New York R&D Center for Translational Medicine and Therapeutics, Inc. New Rochelle New York Department of Biomedical Engineering and Cleveland Clinic, Cleveland, Ohio. Department of Pulmonary, Allergy and Critical Care Medicine, College of Physicians and Surgeons, Columbia University, New York, New York Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, AB, Canada T6G 2P5 Laboratory Animal Research Center, Soochow University School of Medicine, Suzhou 215123, China Department of Oncology Nanfang Hospital, Southern Medical University Guangzhou China Department of Nephrology, the First Affiliated Hospital of China Medical University, Shenyang 110001, People's Republic of China Linyi University, Linyi 276000, China Centre for Disruptive Photonic Technologies & Division of Physics and Applied Physics School of Physical and Mathematical Sciences Nanyang Technological University 637371 Singapore Department of Neurology and Neuroscience Center, First Hospital of Jilin University, Changchun, China The Affiliated Children Hospital of Medical School, Zhejiang University, Hangzhou 310003, Zhejiang, China. hjsl@mail.hz.zj.cn State Key Laboratory of Advanced Processing and Recycling of Nonferrous Metals, Lanzhou University of Technology, 730050 Lanzhou, Gansu, P. R. China Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, The Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, China Department of Mechanical Engineering, University of Houston, Houston, Texas 77204, United States Department of Clinical Laboratory Affiliated Kunshan Hospital of Jiangsu University Suzhou Jiangsu China Health Management Center, Southwest Hospital, Army Military Medical University, Chongqing 400038, China Trauma Center, Southern Central Hospital of Yunnan Province (First People’s Hospital of Honghe State), Yunnan, People’s Republic of China, 661199 1General Clinical Research Center, Nanjing First Hospital, Nanjing Medical University, Nanjing, China. Henan Key Laboratory of New Optoelectronic Functional Materials, College of Chemistry and Chemical Engineering, Anyang Normal University, 436 Xian’ge Road, Anyang 455000, PR China Department of Ultrasound, HeBei General Hospital Shijiazhuang, Hebei, China Department of Pathology, Beijing Cancer Hospital, Beijing 100142, PR China Department of Nephrology and Rheumatology, Children's Hospital of Fudan University, Shanghai, China. Department of Nephrology Xuyi People's Hospital Huaian China Department of Neurology, Ruprecht-Karls-University Heidelberg, Heidelberg, Germany Department of Biomedical Sciences, Florida State University, College of Medicine, Tallahassee, FL, USA 2Department of Oncology, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China. Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi'an, Shaanxi Province, China. Department of Biomedical Sciences Florida State University, College of Medicine Tallahassee Florida Engineering Research Center of Environmental DNA and Ecological Water Health Assessment Shanghai Ocean University Shanghai China; Shanghai Universities Key Laboratory of Marine Animal Taxonomy and Evolution Shanghai Ocean University Shanghai China Department of Rheumatology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China Peking University Sixth Hospital/Institute of Mental Health, and the Key Laboratory of Mental Health, National Clinical Research Center for Mental Disorder, Ministry of Health, Peking University, Beijing, China Shanghai Key Laboratory of Multidimensional Information Processing East China Normal University Shanghai China Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Anhui Provincial Laboratory of Population Health and Eugenics, Hefei 230032, China. Department of Neurology and Neuroscience Center, The First Hospital of Jilin University, Changchun, China Department of Respiratory Medicine, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, P.R. China Department of Rheumatism Children's Hospital of Fudan University Shanghai China Department of Biology and Skidmore Microscopy Imaging Center, Skidmore College, Saratoga Springs, NY, USA. Department of Clinical Laboratory, XuZhou Central Hospital, China Changchun Children's Hospital, Changchun, Jilin, China (mainland) Department of Chemical and Biomedical Engineering FAMU‐FSU College of Engineering Florida State University Tallahassee FL 32310 USA; Department of Biomedical Sciences College of Medicine Florida State University Tallahassee FL 32306 USA Department of Neurology and Neuroscience Center, The First Hospital of Jilin University, Jilin University, Changchun, China Sleep Center, Department of Respiratory Medicine, Second Affiliated Hospital, Soochow University, Suzhou 215004, China. Jiangsu Center for Drug Screening, China Pharmaceutical University Contribution from the Department of Chemistry and Biochemistry, The University of Texas at Austin, 1 University Station, A5300, Austin, Texas 78712-0165 Department of Housing and Urban-Rural Development of Heilongjiang Province, Harbin 150070, China School of Microelectronics, Northwestern Polytechnical University, Taicang, 215400 Suzhou, China Department of Ultrasound, The Affiliated Huai’an No. 1 People’s Hospital of Nanjing Medical University, Huai’an, Jiangsu 223300, China State Key Laboratory of Crop Genetics and Germplasm Enhancement, College of Agronomy Nanjing Agricultural University/JCIC‐MCP Nanjing 210095 Jiangsu China State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources School of Chemistry and Pharmacy of Guangxi Normal University Guilin China Department of Cardiothoracic Surgery, Zaozhuang Municipal Hospital, Zaozhuang, Shandong 277000, P.R. China Radiology Department, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China. Department of Gynecologic Oncology, Shandong Cancer Hospital Affiliated to Shandong University, Shandong Academy of Medical Sciences, Jinan, Shandong Province, People's Republic of China; Division of Gynecologic Oncology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA College of Agriculture and Biotechnology Zhejiang University Hangzhou 310058 China; National Key Laboratory of Plant Molecular Genetics and National Center of Plant Gene Research Institute of Plant Physiology and Ecology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 200032 China Department of Physics, Emory University, Atlanta, Georgia 30322, United States Departments of Chemistry, and ‡Physics, and §the Center for Theoretical Biological Physics, Rice University, Houston, Texas 77030, United States Xiamen China CAS Key Laboratory of Science and Technology on Applied Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China Grade Three-level Laboratory of TCM Preparation, State Administration of Traditional Chinese Medicine , The First Affiliated Hospital/College of integrated Chinese and Western Medicine of Anhui University of Chinese Medicine , Hefei , China Institute of Molecular Medicine, University of Oxford, Headington, Oxford OX3 9DS, UK. Department of Ophthalmology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, Hubei Province, China. Department of Ultrasound, Hebei General Hospital, Shijiazhuang, Hebei, China (mainland) Department of Cardiology, The First Affiliated Hospital, Harbin Medical University, Harbin, China Department of Immunology and Rheumatology; The Frist Affiliated Hospital of Wenzhou Medical University; Wenzhou 325035 China Institute of Mental Health, Peking University, Beijing 100083, China. The Mongolian medical & TCM Hospital of Wuhai Inner Mongolia, PR China. Department of Clinical Pharmacology, National Institute on Drug Dependence, Peking University, Beijing, China. Department of Breast Surgery, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China (mainland) Department of Respiratory and Critical Care Medicine, The Fourth Affiliated Hospital, School of Medicine Zhejiang University Yiwu China Hangzhou Normal University, Hangzhou, China MOE Key Laboratory of Cluster Science; Key Laboratory of Photoelectronic/Electrophotonic Conversion Materials; School of Chemistry and Chemical Engineering; Beijing Institute of Technology; P. R. China School of Chemistry Beihang University Beijing 100191 China Department of Pathology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100021 , China Siping Central Hospital, Siping, China Department of Neurosurgery Huashan Hospital Fudan University Shanghai P. R. China Department of Health Services Research and Policy, London School of Hygiene & Tropical Medicine, London, United Kingdom; Centre for Experimental Cancer Medicine, Barts Cancer Institute, Queen Mary University of London, London, United Kingdom College of Plant Protection, Yangzhou University, Yangzhou 225009, China Center for Osteoporosis and Skeletal Aging, Veterans Affairs Medical Center, and Department of Medicine, Medical College of Pennsylvania–Hahnemann School of Medicine, Philadelphia, Pennsylvania 19104; ‡Division of Endocrinology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205; and §School of Dentistry, University of Southern California, Los Angeles, California 90089 Department of Mechanical Engineering, University of Houston, Houston, TX, USA Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Qingdao, China AmCare Genomics Laboratory Guangzhou Guangdong Province China Department of Rheumatology, Children's Hospital of Fudan University, Children's National Medical Center Department of Oncology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China Medical Department Shandong Energy Zibo Mining Group Co. Ltd. Central Hospital Zibo China MOE Key Laboratory of Cluster Science, School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing 102488, China The Department of Materials Science and Engineering, The Department of Electrical Engineering, University of Texas at Arlington, Arlington, Texas 76019, and The Department of Mechanical Engineering, University of Houston, Houston, Texas 77004 Department of Breast Surgery, The Second Affiliated Changzhou People's Hospital of Nanjing Medical University, Changzhou, Jiangsu 213000, P.R. China Institute of Clinical Pharmacy, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang, China The Mount Sinai Bone Program Mount Sinai School of Medicine New York New York School of Animal Husbandry and Veterinary Medicine, Jiangsu Vocational College of Agriculture and Forestry, Jurong 212400, P. R. China Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan China Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing 211198, China Departments of General Surgery, The Affiliated Changzhou No. 2 People's Hospital, Nanjing Medical University, Changzhou, China. Department of Urology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, 210029, China School of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, China Qinghai University Affiliated Hospital, Xining, Qinghai Province State Key Laboratory of Crystal Materials, Center for Optics Research and Engineering, Shandong University, Jinan 250100, P. R. China Laboratory Animal Center, Jinzhou Normal University, Jinzhou, Liaoning, China Department of Orthopaedics, Binzhou Central Hospital, Binzhou, China. Department of Ophthalmology, Huashan Hospital, Fudan University Shanghai, China. Department of Gastroenterology Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong 250117, P.R. China The Mount Sinai Bone Program, Departments of Medicine and Pediatrics, Mount Sinai School of Medicine, New York, NY 10029; The Mount Sinai Bone Program and The Thyroid Research Unit at the Bronx Veterans Affairs Medical Center, Mount Sinai School of Medicine, New York, NY 10029; Department of Endocrinology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China; Institute of Endocrinology & Metabolism, Anhui Medical University, Hefei, Anhui, China School of Pharmaceutical Sciences & Institute of Materia Medica, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 250117, Shandong, P. R. China Department of Chemistry, Texas A&M University, P.O. Box 30012, College Station, Texas 77842-3012, and Department of Chemical Engineering, Texas A&M University, MS 3122, College Station, Texas 77843-3122 Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. sunli.gz_1980@yahoo.com 3 SUGEN, Inc., 230 East Grand Ave., South San Francisco, CA 94080-4811, USA Department of Clinical Laboratory, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450000, P.R. China Department of Orthopedics, Guizhou Provincial People’s Hospital, Guiyang 550002, China Institute of Optoelectronic Technology, Key Lab of Materials for Information Storage and Display, Beijing Jiaotong University, Beijing 100044, China. Division of Orthopaedic Trauma & Adult Reconstruction, Department of Orthopaedic Surgery, Jersey City Medical Center - RWJBarnabas Health, Jersey City, NJ, USA Department of Cardiology, China-Japan Friendship Hospital, Beijing 100029, China Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States Division of Endocrinology and Metabolism, Mount Sinai School of Medicine, and Bronx Veterans Affairs Geriatric Research Education and Clinical Center, New York 10029; Mount Sinai Bone ProgramMount Sinai School of MedicineNew YorkNew YorkUSA Anesthesia and Operation Center, General Hospital of PLA, Beijing 100853, China. sunli22@sohu.com Laboratory of the second people's Hospital of Jiaxing 314000, Zhejiang Province, China. lilssun@163.com. State Key Laboratory of Soil and Sustainable Agriculture, Institute of Soil Science, Chinese Academy of Sciences, Nanjing, Jiangsu, China; State Key Lab of Crop Genetics and Germplasm Enhancement, Cytogenetics Institute, Nanjing Agricultural University/JCIC-MCP, Nanjing, Jiangsu, China Department of Biology, Skidmore College, Saratoga Springs, NY, USA Children's Hospital of Fudan University Department of Nephrology, The First Affiliated Hospital of China Medical University, Shenyang 110001, China Shandong Provincial Qianfoshan Hospital The First Hospital Affilliated with Shandong First Medical University Jinan Shandong China Department of Health Service Management, School of Public Health, Tianjin Medical University, Tianjin, 300070, China Authors' Affiliations: 1Department of Medical Oncology, National Cancer Centre, Singapore; 2DanDrit Biotech A/S, Copenhagen, Denmark; 3Singapore General Hospital, Singapore; and 4The Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark National Engineering Research Center for Efficient Utilization of Soil and Fertilizer Resources, College of Resources and Environment of Shandong Agricultural University, Taian, China 1Department of Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, P.R. China. Institute of Mental Health,Peking University, Beijing 100083, China. Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck & Co., Inc., West Point, Pennsylvania, USA Departments of cMedicine and College of Traditional Chinese Medicine, Jilin Agricultural University, Changchun 130118, China State Key Laboratory of Silicate Materials for Architectures, Wuhan University of Technology, Wuhan 430070, PR China School of Physics and Center for Nanoscale Characterization & Devices (CNCD) Wuhan National Laboratory for Optoelectronics (WNLO) Huazhong University of Science and Technology (HUST) Wuhan 430074 China Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Pathology Peking University Cancer Hospital & Institute Beijing China School of Medicine, Jiangsu University, Zhenjiang, Jiangsu 212013, P.R. China Peking University Sixth Hospital/Institute of Mental Health Beijing China; National Clinical Research Center for Mental Disorders & Key Laboratory of Mental Health Ministry of Health (Peking University Beijing China Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029; Department of Clinical Laboratory, Xuzhou Central Hospital, China Department of Rheumatology, Children’s Hospital of Fudan University, National Children’s Medical Center , Shanghai, China Department of Medical Oncology, Central Hospital of Xuzhou, the Cancer Institute of Southeast University, Xuzhou 221009, China. Department of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, Florida 32306, United States Department of Hepatology, The Third Hospital of Zhenjiang Affiliated Jiangsu University , Zhenjiang 212003 , Jiangsu Province , China Laboratory for Marine Biology and Biotechnology, Pilot National Laboratory for Marine Science and Technology (Qingdao), Qingdao, China; CAS and Shandong Province Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Center for Ocean Mega-Science, Chinese Academy of Sciences, Qingdao, China Peking University Sixth Hospital & Peking University Institute of Mental Health,China Department of Oncology, Shengjing Hospital of China Medical University Department of Ophthalmology, Huashan Hospital Affiliated to Fudan University Shanghai 200040, China. Department of Anesthesiology, The Second Affiliated Hospital of Air Force Medical University, Xi’an 710038, China Departments of Medicine and Pharmacological Sciences and Center for translational Medicine and Pharmacology, Icahn School of Medicine at Mount Sinai Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing, Jiangsu, China Department of Urology, The First Affiliated Hospital with Nanjing Medical University, Nanjing 210029, China Jiangsu Center for Pharmacodynamics Research and Evaluation, China Pharmaceutical University, Nanjing 210009, PR China The Mount Sinai Bone Program, Department of Medicine Icahn School of Medicine at Mount Sinai New York New York Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Qingdao, China; Collaborative Innovation Center of Deep Sea Biology, Zhejiang University, Hangzhou, China Department of Stomatology First Outpatient Clinic, General Logistics Department of Chinese PLA, Beijing, China. Department of Gynecologic Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, P. R. China Department of Cardiology, the First Affiliated Hospital, Harbin Medical University, Harbin, Heilongjiang Province, China; From the Departments of Neurology (L.S., R.V.) and Physiology (H.H.M.), Ruprecht-Karls-University Heidelberg, Heidelberg, Germany. Department of Health Services Research and Policy, London School of Hygiene and Tropical Medicine , London , United Kingdom Department of Oncology, Affiliated Hospital of Xuzhou Medical College, Xuzhou 221002, Jiangsu Province, China. Department of Critical Medicine, Jinan Central Hospital of Shandong University, Jinan, Shandong 250013, People’s Republic of China. College of Transportation, Shandong University of Technology, Zibo 255049, China Department of Gastroenterological Surgery, Xijing Hospital, The Fourth Military Medical University, Xi'an, China Department of Neurobiology and Department of Neurology of Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China; NHC and CAMS Key Laboratory of Medical Neurobiology, MOE Frontier Science Center for Brain Research and Brain-Machine Integration, School of Brain Science and Brain Medicine, Zhejiang University, Hangzhou, China Department of Gastroenterological Surgery, Xi’an Honghui Hospital, Xi’an, China Mount Sinai Bone Program and Department of Medicine, Mount Sinai School of Medicine, New York. Department of Pharmacy; Institute of Clinical Pharmacy Department of Health Services Research and Policy, London School of Hygiene & Tropical Medicine, London, United Kingdom; Wolfson Institute of Population Health, Queen Mary University of London, London, United Kingdom Rehabilitation and Treatment Centre for Cerebral Palsy, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, China School of Horticulture and Plant Protection Yangzhou University Yangzhou China Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Qingdao, China; Laboratory for Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, Qingdao, China Nanjing University of Science and Technology 1 School of Electronic and Optical Engineering, , Nanjing 210094, China Department of Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, China Department of Nephrology, The First Affiliated Hospital of China Medical University, Shenyang, People’s Republic of China Department of Digestive Surgery, Xijing Hospital, Fourth Military Medical University, 710032, Xi'an, Shaanxi, China Dizziness Clinic, Jilin Provincial Academy of Chinese Medicine Sciences , No. 20 Gongnong Street, Changchun 130000 , Jilin , China Icahn School of Medicine at Mount Sinai, New York, NY, USA University of Pittsburgh. Department of Hepatic Biliary Pancreatic Medicine First Hospital of Jilin University Changchun China Peking University Sixth Hospital/Institute of Mental Health, Beijing, China; National Clinical Research Center for Mental Disorders & Key Laboratory of Mental Health, Ministry of Health (Peking University), Beijing, China *Mount Sinai Bone Program, Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029; The University of Texas, M. D. Anderson Cancer Center, Houston, Texas 77030, United States Department of Gynecological Oncology, Cancer Hospital (Institute), Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China. Xiamen Amoytop Biotech Co., Ltd.,Xiamen,Fujian Province,P.R. China aCenter for Osteoporosis and Skeletal Aging, Department of Medicine, Medical College of Pennsylvania and Veterans Affairs Medical Center, Philadelphia, Pennsylvania 19104 College of Chemistry, Nanchang University, Nanchang, Jiangxi 330031, People’s Republic of China CAS and Shandong Province Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Center for Ocean Mega-Science, Chinese Academy of Sciences, Qingdao, China; Laboratory for Marine Biology and Biotechnology, Pilot National Laboratory for Marine Science and Technology (Qingdao), Qingdao, China; College of Earth and Planetary Sciences, University of Chinese Academy of Sciences, Beijing, China CAS Key Laboratory of Science and Technology on Applied Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, P.R. China; University of Chinese Academy of Sciences, Beijing 100049, P.R. China Departments of Gynecological Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China Department of Animal Nutrition and Management, Swedish University of Agricultural Sciences, SE-750 07 Uppsala, Sweden; Department of Molecular Sciences, Swedish University of Agricultural Sciences, SE-750 07 Uppsala, Sweden Department of Clinical Laboratory, Affiliated to Medical College of Southeast University and Xuzhou Central Hospital, Xuzhou, People’s Republic of China Department of Respiratory and Critical Care Medicine First Affiliated Hospital of Anhui Medical University Hefei China Department of Hematology, The Second Hospital of Hebei Medical University, Key Laboratory of Hematology, Shijiazhuang, Hebei 050000, P.R. China Department of Pathophysiology, School of Basic Medical Science, Central South University, Changsha 410078, China. Department of Thyroid Surgery, Dalian Central Hospital Affiliated to Dalian Medical University, Dalian, 116033, Liaoning Province, China Division of Digestive Surgery, Xijing Hospital of Digestive Disease, Fourth Military Medical University, Xi’an, Shaanxi, China Merck Sharp & Dohme Corp. Whitehouse Station NJ USA Department of Mechanical Engineering and Texas Center for Superconductivity (TcSUH), University of Houston, Houston, Texas 77204, United States Mount Sinai Bone Program, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York Department of Clinical Laboratory, Affiliated to Medical College of Southeast University and Xuzhou Central Hospital, Xuzhou, People's Republic of China School of Nursing, Tianjin Medical University, Tianjin 300070, China School of Chemical Engineering, East China University of Science and Technology, 200237 Shanghai, China State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China; Savaid Medical School, University of Chinese Academy of Sciences, Beijing, P. R. China Institute of Oceanology, Chinese Academy of Sciences, Qingdao, People's Republic of China Gynaecological Clinic and Pre-Pregnancy Clinic, Family Planning Service Station, Zaozhuang, Shandong 277300, China Department of Public Health; Qingdao University; Qingdao 266021; China Department of Chemistry, Merkert Chemistry Center, Boston College, Chestnut Hill, Massachusetts 02167 The Mount Sinai Bone Program, Department of Medicine, Icahn School of Medicine at Mount Sinai, Mount Sinai Hospital, New York, NY 10029 Mount Sinai Bone Program, Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029; and SUGEN, Inc., 230 East Grand Avenue, South San Francisco, California 94080-4811 Department of Rheumatology, Children's Hospital of Fudan University , Shanghai, China School of Energy and Environment and Key Laboratory of Energy Thermal Conversion and Control of Ministry of Education, Southeast University, Nanjing, People’s Republic of China Departments of Nephrology and Rheumatology, Department of Breast Surgery, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China College of Animal Science and Technology, Northeast Agricultural University, Harbin, Heilongjiang, China Shanghai University of Traditional Chinese Medicine, Shanghai, China. Key Laboratory of Horticultural Plant Biology (Ministry of Education), Huazhong Agricultural University, Wuhan 430070, China Department of Pharmacy People's Hospital of Xinjiang Uygur Autonomous Region Urumqi China; Institute of Clinical Pharmacy People's Hospital of Xinjiang Uygur Autonomous Region Urumqi China Department of Anesthesiology, 7th Medical Center, General Hospital of PLA, Beijing 100700, P.R. China Department of Chemistry, Texas A&M University, P.O. Box 30012, College Station, Texas 77842-3012 Department of Oncology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China; Department of Oncology, Air Force Medical Center of PLA, Air Force Medical University, Beijing 100089, China School of Public Health Tianjin Medical University Tianjin 300070 China Guangxi Key Laboratory of Brain and Cognitive Neuroscience, Guilin Medical University, Guilin, 541001, China Mount Sinai Bone Program and; Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029; MOE Key Laboratory of Biosystems Homeostasis & Protection, State Conservation Centre for Gene Resources of Endangered Wildlife, College of Life Sciences Zhejiang University Hangzhou China Anhui Provincial Key Laboratory for Conservation and Exploitation of Biological Resources College of Life Science Anhui Normal University Wuhu 241000 China The University of Leeds Leeds UK Department of Biomedical Engineering Cleveland Clinic Cleveland Ohio USA Department of Chemistry; Huaibei Normal University; Huaibei; P. R. China National Engineering Research Center of Cereal Fermentation and Food Biomanufacturing, Jiangnan University, Wuxi 214122, China; Jiangsu Provincial Research Center for Bioactive Product Processing Technology, Jiangnan University, Wuxi 214122, China Murad Research Institute for Modernized Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China Peking University Sixth Hospital and Institute of Mental Health, Beijing, China; National Clinical Research Centre for Mental Disorders & Key Laboratory of Mental Health, Ministry of Health (Peking University), Beijing, China Department of Radiology, Xuan Wu Hospital, Capital Medical University Beijing 100053, China. Mental Health Institute, Peking University, Beijing 100083, China. Department of Cardiology, the First Affiliated Hospital, Harbin Medical University, Harbin 150001, Heilongjiang Province, P. R. China School of Pharmacy, Pharmaceutical Engineering Technology Research Center, Anhui University of Chinese Medicine, Hefei 230012, China; Anhui Province Key Laboratory of Pharmaceutical Preparation Technology and Application, Hefei 230012, China Department of Neurology, Tianjin Medical University General Hospital, Tianjin 300052, China; Email: sunli_2000@hotmail.com. †The Center for Microbes, Development, and Health, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, China;; ‡University of Chinese Academy of Sciences, Beijing, China;; §Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, China; Department of Anesthesiology; Beijing Military Region General Hospital; Beijing China Department of Elderly Respiratory Medicine, Shaanxi Provincial People's Hospital, Xi'an, Shaanxi, China.; Department of Elderly Medicine, The Affiliated Shaanxi Provincial People's Hospital, Xi'an Medical College, Xi'an, Shaanxi, China. National Center for Safety Evaluation of Drugs National Institutes for Food and Drug Control A8 Hong Da Middle Street, Yizhuang Economic Development Area Beijing 100176 China Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China Department of Colorectal Surgery, Cleveland Clinic, Cleveland, Ohio Key Laboratory of E&M, Zhejiang University of Technology, Ministry of Education & Zhejiang Province, Hangzhou, 310014, China Department of Anesthesiology and Pain Center, Shanghai Changhai Hospital Naval Medical University Shanghai China Institute of Interdisciplinary Medical Science, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China Basic Medical College, Guilin Medical University, Guilin, China Department of Neurology, The First Hospital of Jilin University, Changchun, Jilin Province, China Mount Sinai Bone Program, Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029; Department of Laboratory Medicine Shanghai Sixth People's Hospital Jinshan Branch Shanghai China Department of Rheumatology Department of Rehabilitation Medicine, Affiliated Hospital of Nantong University, Nantong, China Department of General Surgery Shengjing Hospital of China Medical University Shenyang China Reproductive Medicine Center, Obstetrics and Gynecology Department, Shengjing Hospital Affiliated to China Medical University, Shenyang 110022, China; Key Laboratory of Reproductive Dysfunction Diseases and Fertility Remodelling of Liaoning Province, Shengjing Hospital Affiliated to China Medical University, Shenyang 110022, China Department of Orthopedics Guizhou Provincial People's Hospital Guiyang China Florida State University College of Medicine, Department of Biomedical Sciences, Tallahassee, Florida, USA Department of Oncology Shengjing Hospital of China Medical University Shenyang China Department of Cardiology, The First Affiliated Hospital, Harbin Medical University, Harbin 150001, Heilongjiang Province, P. R. China Key Laboratory of Wheat and Maize Crops Science, College of Agronomy, Henan Agricultural University, Zhengzhou 450002, China Henan Provincial Key Laboratory of Nanocomposites and Applications, Institute of Nanostructured Functional Materials, Huanghe Science and Technology College, Zhengzhou 450006, China Department of Neurology and Neuroscience Center, The First Hospital of Jilin University, Jilin University, Changchun, China; Cognitive Center, Department of Neurology, The First Hospital of Jilin University, Jilin University, Changchun, China. Mount Sinai Bone ProgramDepartment of Medicine and GeriatricsMount Sinai School of MedicineDivision of EndocrinologyGeriatric Research Education and Clinical Center (GRECC)Veterans Affairs Medical CenterNew YorkNew YorkUSA Department of Digestive Surgery, Xijing Hospital of Digestive Diseases, Fourth Military Medical University of China, Xi'an, Shaanxi Province, China. State Key Laboratory of Pathogenesis, Prevention, and Treatment of Central Asian High Incidence Diseases, Clinical Medical Research Institute, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China Center of Laboratory Medicine, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, 210011 Jiangsu P.R. China Department of Biochemistry, Max F. Perutz Laboratories, University of Vienna, Vienna, A–1030, Austria Department of Respiratory and Critical Care Medicine, First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, P.R. China CAS Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, China Department of Gynecological Oncology, Cancer Hospital, Chinese Academy of Medical Science, Peking Union Medical College, Beijing, PR China. xjsunli@sina.com Department of Clinical Research, Singapore General Hospital, Singapore 169608. Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China School of Humanities Management, Changchun University of Chinese Medicine, Changchun, Jilin, China. Department of Rheumatology, Children's Hospital of Fudan University, Shanghai, China. State Key Laboratory of Cancer Biology Institute of Digestive Diseases Xijing Hospital Fourth Military Medical University Xi'an China State Key Laboratory of Cancer Biology & Xijing Hospital of Digestive Diseases, the Fourth Military Medical University, Department of Pharmacology, School of Pharmacy, the Fourth Military Medical University, and Department of Gynecology and Obstetrics, Tangdu Hospital, the Fourth Military Medical University Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai 200031, China Department of Rheumatology Children's Hospital of Fudan University, National Children's Medical Center Shanghai China Department of Rehabilitation, Daqing Longnan Hospital, Daqing, Heilongjiang 163453, P.R. China Center for Animal Experiment/ABSL-III Laboratory, State Key Laboratory of Virology, Wuhan University School of Basic Medical Sciences, Wuhan, China. Tianjin Medical University General Hospital , Ministry of Education and Tianjin City, Tianjin Neurological Institute , Key Laboratory of Post-Neuroinjury Repair and Regeneration in Central Nervous System , Tianjin , China Xiamen Amoytop Biotech Co., LTD., Xiamen, China State Key Laboratory of Cellular Stress Biology and School of Life Sciences, Xiamen University, Xiamen, Fujian 361005, China Department of Neurology and Neuroscience Center First Hospital of Jilin University Changchun China Department of Gynecology, Xi’an First Hospital, Xi’an, Shaanxi 710002, China Department of Clinical Laboratory The First Affiliated Hospital of Zhengzhou University Zhengzhou China Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, United Kingdom Department of Infectious Diseases Tangdu Hospital Fourth Military Medical University Xi'an Shannxi China d Jiujiang Municipal Bureau of Ecology and Environment, Jiujiang, Jiangxi 332005, China Department of Rheumatology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325003, P.R. China State Key Laboratory of Food Nutrition and Safety, Key Laboratory of Industrial Microbiology, Ministry of Education, Tianjin Key Laboratory of Industrial Microbiology, College of Biotechnology, Tianjin University of Science and Technology, Tianjin, 300457, China Department of Chemistry, Zhengzhou University, 100 Science Avenue, Zhengzhou, Henan Province 450001, PR China Peking University Sixth Hospital and Peking University Institute of Mental Health Beijing China; NHC Key Laboratory of Mental Health (Peking University) and National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital) Beijing China Department of Pharmacy, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang, China; Institute of Clinical Pharmacy, People\'s Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang, China Department of Ophthalmology, The First Affiliated Hospital, China Medical University, Shenyang 110001, China. sunlishu@hotmail.com Department of Hematology, Shengli Hospital of Shengli Petroleum Administration Bureau,Dongying 257055, Shandong Province, China. Department of Radiation Oncology Huadong Hospital Fudan University Shanghai 200040 P. R. China College of Chemistry, Nanchang University, Nanchang 330031, China Department of Orthopaedics Guizhou Provincial People's Hospital Guizhou China Pharmaceutical Engineering Technology Research Center, School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China; Anhui Province Key Laboratory of Pharmaceutical Preparation Technology and Application, Hefei 230012, China State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Science, Guangxi Normal University, Guilin 541004, China Shenzhen Key Laboratory of Gene Regulation and Systems Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen 518055, China; Department of Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen 518055, China Liaoning Provincial Center for Disease Control and Prevention, Shenyang 110005, China Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, PR China Vivian L. Smith Department of Neurosurgery, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA; Center for Stem Cell and Regenerative Medicine, The University of Texas Health Science Center at Houston, Houston, TX, USA; Department of Oncology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China The Mount Sinai Bone Program, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029; Shanghai Key Laboratory of Multidimensional Information Processing, East China Normal University, Shanghai, China Division of Environment and Sustainability The Hong Kong University of Science and Technology Hong Kong China Xiamen Amoytop Biotech Company, Ltd., 330 Wengjiao Road, Xiamen, Fujian, China 361022 Authors' Affiliations: 1State Key Laboratory of Cancer Biology & Xijing Hospital of Digestive Diseases; and 2Department of Dermatology, the Fourth Military Medical University, Xi'an, China Medicine, Mount Sinai School of Medicine, New York, NY 10029; School of Physics State Key Laboratory of Crystal Materials Shandong University Jinan 250100 China Department of Neurology and Neuroscience Center The First Hospital of Jilin University Changchun China Department of Molecular Sciences, Swedish University of Agricultural Sciences , Uppsala, SE-750 07 , Sweden College of Liffe Science, Xinjiang Shihezi University, Shihezi 823003, China. State Key Laboratory of Crystal Materials, Center for Optics Research and Engineering, Shandong University, Jinan 250100, P. R. China; Key Laboratory of Laser & Infrared System, Shandong University, Ministry of Education, Qingdao 266237, China The Mount Sinai Bone Program, Department of Medicine, and Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY, USA School of Medical Science and Laboratory Medicine, Jiangsu University, Zhenjiang, Jiangsu 212013, China The First Ward, Shannxi Provincial People’s Hospital, Xi’an 710068, China Department of Orthopaedics People's Hospital of Guizhou Province Shiyan China Chief Physician of Jilin Academy of Chinese Medicine, Chaoyang District, Changchun City, Jilin Province, China. 1State Key Laboratory of Cancer Biology and Institute of Digestive Diseases, Xijing Hospital, the Fourth Military Medical University, Xi'an, Shaanxi Province, P.R. China and Department of Molecular Sciences, Swedish University of Agricultural Sciences, SE-750 07 Uppsala, Sweden Chinese Academy of Inspection and Quarantine, No. 11, Ronghua South Road, Yizhuang Economic and Technological Development Zone, Beijing 100176, China State Key Laboratory of Pathogenesis, Prevention, and Treatment of Central Asian High Incidence Diseases, Clinical Medical Research Institute, The First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China The Mount Sinai Bone Program, Icahn School of Medicine at Mount Sinai, New York, NY 10029;; Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029; Department of Geosciences, Texas Tech University, Lubbock, TX, USA College of Chemistry, Nanchang University, Nanchang 330031, Jiangxi, P.R. China; National Research Center for Carbohydrate Synthesis, Jiangxi Normal University, Nanchang 330022, Jiangxi, P.R. China State Key Laboratory of Cancer Biology & Xijing Hospital of Digestive Diseases Fourth Military Medical University Xi'an China Division of Nanomaterials and Chemistry Hefei National Laboratory for Physical Sciences at Microscale Collaborative Innovation Center of Suzhou Nano Science and Technology Department of Chemistry, Hefei Science Center, CAS University of Science and Technology of China Anhui 230026 P. R. China Department of Health Services Research and Policy, London School of Hygiene and Tropical Medicine, London, England. Prenatal Diagnosis Center, Women and Children’s Hospital, School of Medicine, Xiamen University, Xiamen, Fujian Province 361000, China Clinical Pharmacy & Pharmacology Research Institute, the Second Xiangya Hospital, Central South University, 139 Renmin Middle Road, Changsha, Hunan Province 410011, People's Republic of China School of Chemical Engineering, East China University of Science and Technology, Shanghai 200237, China Sichuan Provincial Center for Disease Control and Prevention, Chengdu, People's Republic of China Department of Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong Province, China Department of Obstetrics and Gynecology, the Affiliated Yantai Yuhuangding Hospital of Qingdao University, No. 20 Yuhuangding East Road, Yantai, Shandong 264000, China.; Department of Obstetrics and Gynecology, the Affiliated Yantai Yuhuangding Hospital of Qingdao University, No. 20 Yuhuangding East Road, Yantai, Shandong 264000, China. School of Life Sciences, Shandong University, 27 Shanda South Road, Jinan 250100, People's Republic of China Key Laboratory of Green and Precise Synthetic Chemistry and Applications, Ministry of Education; Department of Chemistry, Huaibei Normal University Department of Orthopaedic Surgery, Icahn School of Medicine at Mount Sinai, New York, NY Department of Dermatology and Venereology Nanjing Medical University Affiliated Wuxi People's Hospital Wuxi China Department of Rheumatology, Children's Hospital of Fudan University, Shanghai, China. lillysun@263.net. Department of Pathology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital and Institute, Beijing 100142, China. Wolfson Institute of Preventive Medicine, Barts Cancer Institute, Queen Mary University of London Charterhouse Square, London, United Kingdom College of Chemical and Environmental Engineering, Shandong University of Science and Technology, Qingdao 266590, China Department of Dermatology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, 210029, P.R. China Beijing Key Laboratory of Photoelectronic/Electrophotonic Conversion Materials; MOE Key Laboratory of Cluster Science; School of Chemistry and Chemical Engineering; Beijing Institute of Technology; Beijing 100081 From Taiho Pharmaceutical Co, Ltd (Y.Y., K.M., N.O., M.W., H.M.), Hanno Research Center, Saitama, Japan, and SUGEN, Inc (J.C., X.W., L.S., C.T., G.M., K.E.L.), South San Francisco, Calif. Department of Elderly Respiratory Medicine, Shaanxi Provincial People's Hospital, Xi'an, China.; Department of Elderly Medicine, the Affiliated Shaanxi Provincial People's Hospital, Xi'an Medical College, Xi'an, China. Department of Laboratory Medicine, The Second Affiliated Hospital, Nanjing Medical University, Nanjing, People's Republic of China. Department of Medicine, Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD 21205; Department of Medicine, Division of Biomolecular Medicine, Boston University School of Medicine, Boston, MA 02118; and Department of Molecular Microbiology and Immunology and Center for Tuberculosis Research, Department of International Health, Johns Hopkins School of Public Health and Hygiene, Baltimore, MD 21205 College of Physics Qingdao University Qingdao 266071 PR China Department of Rheumatology, Children’s Hospital of Fudan University, National Children’s Medical Center, Shanghai, China Division of Digestive Surgery, Xijing Hospital of Digestive Diseases, Fourth Military Medical University, 710032, Xi’an, Shaanxi, China Zhejiang Academy of Agricultural Sciences, Institute of Horticulture, Hangzhou, Jianggan, China Department of Rheumatology and Immunology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China Division of Endocrinology, Diabetes and Bone Disease, Mount Sinai School of Medicine, New York, NY, USA Department of Clinical Laboratory, Xuzhou Central Hospital Affiliated to Southeast University, Xuzhou 221009, China New Drug Screening Center China Pharmaceutical University Nanjing China Peking University Sixth Hospital/Institute of Mental Health, National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing, China; Key Laboratory of Mental Health, Ministry of Health, Peking University, Beijing, China Department of Histology and Embryology, Guilin Medical College, Guilin, Guangxi 541004, China. sunli2196@glmc.edu.cn Department of Orthopedics, Guizhou Province People's Hospital Guiyang 550002, China. School of Engineering and Applied Sciences; Harvard University; Cambridge; USA Department of Neurology, Hongqi Hospital Affiliated to Mudanjiang Medical University Mudanjiang 157011, Heilongjiang, China. Heilongjiang Key Laboratory of Ischemic Stroke Prevention and Treatment Mudanjiang 157011, Heilongjiang, China. From the Division of Brain Sciences, Imperial College London, United Kingdom (M.M., R.V.); Departments of Neurology (M.M., L.S., R.V.) and Cardiology (L.L.), University of Heidelberg, Germany; Department of Neurology, Medical Faculty Mannheim (M.F.), Computer Assisted Clinical Medicine (A.N., L.S.), University Heidelberg, Mannheim, Germany; and Department of Cardiometabolic Research, Boehringer Ingelheim, Biberach, Germany (J.v.R.). Department of Medicine Engineering Research Center for the Development and Application of Ethnic Medicine and TCM (Ministry of Education) Guizhou Medical University Guiyang China; School of Pharmaceutical Sciences Guizhou Medical University Guiyang China Department of Urology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, Jiangsu, China (mainland) Chair of Structural Dynamics and Earthquake Engineering Institute of Structural Engineering ETH Zurich Switzerland Department of Gynecology Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases Shanghai China; Department of Ultrasound Obstetrics and Gynecology Hospital of Fudan University Shanghai China Department of Pediatrics, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei 442000, P.R. China Department of Microbiology, Swedish University of Agricultural Science, Uppsala BioCenter, Uppsala, Sweden Departments of Gynecological Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital l & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen; Departments of Gynecological Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China Department of Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China Jiangsu key laboratory of Drug Screening, China Pharmaceutical University, Nanjing 210009, China State Key Laboratory of Soil and Sustainable Agriculture Institute of Soil Science Chinese Academy of Sciences No. 71 East Beijing Road Nanjing 210008 China Department of Biochemistry, Kanazawa Medical University School of Medicine, 1-1 Daigaku, Uchinada, Kahoku-gun, Ishikawa 920-0293, Japan; Department of Nephrology, the First Hospital of China Medical University, Shenyang, People's Republic of China Department of Physics, N201 Mathematics and Science Center, Emory University, 400 Dowman Drive, Atlanta, Georgia 30322-2430, United States Department of Medicine, College of Physicians and Surgeons, and Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, PR China Henan Provincial Key Laboratory of Nanocomposites and Applications, Institute of Nanostructured Functional Materials, Huanghe Science and Technology College, Zhengzhou, Henan 450006, China Anhui Provincial Key Laboratory of Molecular Enzymology and Mechanism of Major Diseases, College of Life Sciences, Anhui Normal University, Wuhu 241000, China; Anhui Provincial Key Laboratory of the Conservation and Exploitation of Biological Resources, College of Life Sciences, Anhui Normal University, Wuhu 241000, China; Key Laboratory of Biomedicine in Gene Diseases and Health of Anhui Higher Education Institutes, College of Life Sciences, Anhui Normal University, Wuhu 241000, China Peking University Sixth Hospital/Institute of Mental Health, China; National Clinical Research Center for Mental Disorders & Key Laboratory of Mental Health, Ministry of Health (Peking University), China Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Qingdao, PR China; Laboratory for Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, Qingdao, PR China Medical College Guizhou University Guiyang China; Department of Orthopedics Guizhou Provincial People's Hospital Guiyang China Department of Rehabilitation, Daqing Longnan Hospital, Daqing, Heilongjiang 163001, P.R. China Department of Physics, N201 Mathematics and Science Center, 400 Dowman Drive Emory University Atlanta GA 30322‐2430 Department of Neuropharmacology Institute of Nautical Medicine Nantong University Jiangsu China Cancer Research Laboratory, University of Auckland School of Medicine, Private Bag 92019, Auckland, New Zealand, and Parke-Davis Pharmaceutical Research, Division of Warner-Lambert Company, 2800 Plymouth Road, Ann Arbor, Michigan 48106-1047 Sixth Hospital/Institute of Mental Health Peking University Beijing China; National Clinical Research Center for Mental Disorders & The Key Laboratory of Mental Health Ministry of Health (Peking University) Beijing China Shengli Hospital of Shengli Petroleum Administration, Dongying, Shandong 257055, P.R. China Department of Chemistry, Texas A&M University, Post Office Box 30012, College Station, Texas 77842-3012 Department of Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China Department of Nephrology, The First Hospital of China Medical University, Shenyang, Liaoning Province, People’s Republic of China The First Affiliated Hospital of Bengbu Medical College & Tumor Hospital Affiliated to Bengbu Medical College, Bengbu 233004, China The State Key Laboratory of VirologySchool of Basic Medical Sciences, Wuhan University Wuhan China State Key Laboratory of Cancer Biology Xijing Hospital of Digestive Diseases Fourth Military Medical University Xi'an China Wolfson Institute of Population Health, Barts CRUK Cancer Centre Queen Mary University of London London UK Department of Laboratory Medicine, The Second Affiliated Hospital of Nanjing Medical University, Nanjing 210011, China Department of Orthopaedics People’s Hospital of Guizhou Province, Guiyang Guangzhou China Department of Cardiology The First Affiliated Hospital of Harbin Medical University Harbin Heilongjiang Province China Department of Stomatology, General Hospital of PLA, Beijing 100853, China. sunli112@sina.com Department of Microbiology, Swedish University of Agricultural Sciences, Uppsala, Sweden Department of Obstetrics and Gynecology, Yuhuangding Hospital Affiliated to Qingdao University, Yantai, China Key Laboratory for Animal Genetics, Breeding, Reproduction and Molecular Design of Jiangsu Province, College of Animal Science and Technology, Yangzhou University, Yangzhou, Jiangsu 225009, China Division of Digestive Surgery, Xijing Hospital of Digestive Disease, Fourth Military Medical University, 710032, Xi’an, Shaanxi, China Department of Neurology and Neuroscience Center Department of Medical Laboratory, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan, China; Henan Key Laboratory of Medical Laboratory, Zhengzhou, Henan, China Peking University Sixth Hospital/Institute of Mental Health, National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital) Faculty of TCM, Medical College, Jinan University, Guangzhou 510632. Central Laboratory of Qinghai University Affiliated Hospital, Qinghai University Affiliated Hospital, Xining, Qinghai province, China Department of Physics and Tsinghua-Foxconn Nanotechnology Research Center, Tsinghua University, Beijing, People’s Republic of China, 100084 Peking University Sixth Hospital/Institute of Mental Health, Key Laboratory of Ministry of Health, Peking University, Beijing 100191, China Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China MOE Key Laboratory of Cluster Science; Beijing Key Laboratory of Photoelectronic/Electrophotonic Conversion Materials; School of Chemistry and Chemical Engineering; Beijing Institute of Technology; Beijing 102488 National Engineering Research Center for Efficient Utilization of Soil and Fertilizer Resources, College of Resources and Environment of Shandong Agricultural University, Tai’an, China Department of Gynecology and Obstetrics, Yantai Hospital of Traditional Chinese Medicine, Yantai, Shandong 264016, P.R. China Northeast Institute of Geography and Agroecology, Chinese Academy of Sciences, Changchun 130012, China. sunli7912@163.com School of Medicine, Center of Prenatal Diagnosis, Women and Children’s Hospital, School of Medicine, Xiamen University, Xiamen, P.R. China MOE Key Laboratory of Cluster Science, Beijing Key Laboratory of Photoelectronic/Electrophotonic Conversion Materials, School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing 102488, People’s Republic of China Department of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, P.R. China Department of Oncology, Shengjing Hospital of China Medical University, Shenyang 110004, China Department of Endocrinology, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210028, P.R. China Department of Chemistry KU Leuven Celestijnenlaan 200F Leuven 3001 Belgium The First Affiliated Hospital of Wenzhou Medical University Wenzhou China State Key Lab of Crop Genetics and Germplasm Enhancement, Cytogenetics Institute, College of Agriculture Nanjing Agricultural University/JCIC‐MCP Nanjing Jiangsu China University of Leeds, UK Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei PR China; Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei PR China Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, People's Republic of China Division of Orthopaedic Trauma and Adult Reconstruction, Department of Orthopaedic Surgery, Jersey City Medical Center - RWJBarnabas Health, Jersey City, NJ, USA Department of Pharmacokinetics, Pharmacodynamics & Drug Metabolism, Merck & Co., Inc., West Point, PA, USA Division of Digestive Surgery, Xijing Hospital of Digestive Diseases, The Fourth Military Medical University, 710032, Xi’an, Shaanxi Province, China Center for Infection and Immunity Institute of Biophysics, Chinese Academy of Sciences Beijing China; University of Chinese Academy of Sciences Beijing China State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen 361102, China Department of Endocrinology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong 250021, China; Shandong Key Laboratory of Endocrinology and Lipid Metabolism, Jinan, Shandong 250021, China; The First Affiliated Hospital of Shandong First Medical University, Jinan, Shandong 250014, China The Mount Sinai Bone Program and Department of Medicine and Pediatrics, Mount Sinai School of Medicine, New York, NY 10029, USA. Peking University Cancer Hospital and Institute, Beijing, China Peking University Sixth Hospital/Institue of Mental Health, Beijing, China; National Clinical Research Center for Mental Disorders, Beijing, China School of BioSciences The University of Melbourne Parkville Victoria Australia College of Physics; Qingdao University; Qingdao 266071; China Department of Hematology, Quanzhou First Hospital, Quanzhou City, Fujian Province, China Department of Hematology, The Second Hospital of Hebei Medical University, Shijiazhuang 050000, China Department of Biological Sciences, Texas Tech University, Lubbock, TX 79409, USA State Key Laboratory of Cellular Stress Biology, Xiamen University Department of Psychology, School of Public Health, Southern Medical University School of Physics & Wuhan National Laboratory for Optoelectronics Huazhong University of Science and Technology (HUST) Wuhan 430074 China Department of Orthopaedics People's Hospital of Guizhou Province Guiyang China Institute of Horticulture Zhejiang Academy of Agricultural Sciences Hangzhou China Department of Oncology; Nanfang Hospital, Southern Medical University; Guangzhou; 510515; People's Republic of China Center for Skeletal Aging and Osteoporosis, Geriatric Medicine and Extended Care Service, VA Medical Center, and Department of Medicine, Medical College of Pennsylvania, Philadelphia, Pennsylvania, U.S.A. Department of Biological Sciences, School of Science , Xi’an Jiaotong-Liverpool University , 111 Ren’ai Road , Suzhou , Jiangsu 215123 , P. R. China Division of Infection and Immunity, Department of Electromagnetic and Laser Biology, Beijing Institute of Radiation Medicine, Beijing 100850, China School of Public Health, Tianjin Medical University, Tianjin 300070, P.R. China Department of Child Psychiatry, Peking University Sixth Hospital/Institute of Mental Health, Key Laboratory of Ministry of Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing 100191, China; Email: sunlioh@bjmu.edu.cn. State Key Laboratory of Rice Biology, Institute of Biotechnology, Zhejiang University, Hangzhou, China College of Physics, Center for Marine Observation and Communications, Qingdao University, Qingdao 266071, China Life Science Research Center, Hebei North University, Zhangjiakou 075000, Hebei Province, China. Department of Microbiology Uppsala BioCenter Swedish University of Agricultural Sciences Uppsala SE 750 07 Sweden Jiangsu Center for Pharmacodynamics Research and Evaluation, China Pharmaceutical University, Nanjing 210009, China Department of Respiratory Diseases, Shaanxi Provincial People's Hospital, Xi'an, Shaanxi 710068, China. State Key Laboratory of Pathogenesis Prevention, and Treatment of Central Asian High Incidence Diseases Clinical Medical Research Institute The First Affiliated Hospital of Xinjiang Medical University Urumqi China Peking University Sixth Hospital/Institute of Mental Health; Key Laboratory of Mental Health, Ministry of Health (Peking University), Beijing, China Jiangsu Cancer Hospital The Affiliated Cancer Hospital of Nanjing Medical University Jiangsu Institute of Cancer Research Nanjing China Department of Histology and Embryology, Guilin Medical University, Guangxi, Guilin, China; and Division of Digestive Surgery, Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi’an 710032 School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts 02138, United States Mount Sinai Bone ProgramDepartments of Medicine and GeriatricsBronx Veterans Affairs Geriatrics Research Education and Clinical Center (GRECC) New York New York 10029 USA Laboratory of Neuro‐Chemistry Tianjin Neurological Institute, Tianjin Medical University General Hospital Tianjin China Mount Sinai Bone Program and Division of Endocrinology, Mount Sinai School of Medicine, New York, 10029, and Endocrine Division and The Geriatric Research Education and Clinical Center, Veterans Affairs Medical Center, Bronx, New York 10468; The Mount Sinai Bone Program, Icahn School of Medicine at Mount Sinai, New York, New York; Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York Department of Gastrointestinal Surgery, Xi’an Jiaotong University School of Medicine Affiliated Honghui Hospital, Xi’an, China. Department of Ophthalmology, Shanghai Huashan Hospital, Fudan University Shanghai, China. The First Hospital of Jilin University, Changchun Jiangsu Cancer Hospital, the Affiliated Cancer Hospital of Nanjing Medical University, Jiangsu Institute of Cancer Research, Nanjing 210009, China Key Laboratory for Animal Genetics, Breeding, Reproduction and Molecular Design, College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China Evans Department of Clinical Research and Department of Medicine, and Department of Biochemistry, Boston University School of Medicine, Boston, MA 02118 Department of Nephrology, Children's Hospital, Fudan University, Shanghai 200032, China. Department of Anesthesiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, China Department of Anesthesiology National Cancer Center/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China College of Chemical Engineering, Shijiazhuang University, Shijiazhuang, Hebei 050035, China Department of Applied Physics and Materials Research Center, The Hong Kong Polytechnic University, Hong Kong SAR, China State Key Laboratory of Stress Biology and Fujian Provincial Key Laboratory of Innovative Drug Target Research, School of Pharmaceutical Sciences Xiamen University Xiamen China Department of Obstetrics and Gynecology, Yantai Hospital of Traditional Chinese Medicine, Yantai, Shandong, China (mainland) SUGEN Inc., South San Francisco, California 94080 Department of Mechanical Engineering, University of Houston, Houston, TX 77204, USA Urology & Nephrology Center, Department of Urology Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College Hangzhou Zhejiang China Merck Research Laboratories, West Point, Pennsylvania Beijing Key Laboratory of Materials Utilization of Nonmetallic Minerals and Solid Wastes; National Laboratory of Mineral Materials; School of Materials Science and Technology; China University of Geosciences; Beijing Department of Obstetrics, Yantai Yuhuangding Hospital , 20 Yudong Road, Zhifu District, Shandong Province, 264000 , Yantai , Shandong , China Shanghai Kidney Development and Pediatric Kidney Disease Research Center Shanghai China; Department of Rheumatology Children's Hospital of Fudan University Shanghai China Henan Key Laboratory of Organic Functional Molecule and Drug Innovation, College of Life Science, Henan Normal University, Xinxiang 453007, China 1The Mount Sinai Bone Program, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA Engineering Research Center for Nanomaterials, Henan University, Kaifeng 475004, China Department of Chemistry Division of Molecular Imaging and Photonics KU Leuven Celestijnenlaan 200F Leuven B‐3001 Belgium Departments of Chemistry and of Chemical Engineering and Materials Science, University of Minnesota, 207 Pleasant Street SE, Minneapolis, Minnesota 55455, and Theoretical Separation Science Laboratory, Rohm and Haas Company, 727 Norristown Road, P.O. Box 0904, Spring House, Pennsylvania 19477 Lung Biology Laboratory, Pulmonary Division, Department of Medicine, and Laboratory Medicine Center The Second Affiliated Hospital Nanjing Medical University Nanjing Jiangsu China Department of Health Services Research and Policy, London School of Hygiene and Tropical Medicine, London, United Kingdom Jiangsu key Laboratory of Drug Screening China Pharmaceutical University Nanjing Jiangsu China Mount Sinai Bone Program, Mount Sinai School of Medicine, and James J. Peters VA Medical Center, New York, NY 10029 Department of Cardiology the First Affiliated Hospital Harbin Medical University Harbin China Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Pathology, Peking University Cancer Hospital (Beijing Cancer Hospital), Beijing The Mount Sinai Bone Program, Icahn School of Medicine at Mount Sinai, New York, NY 10029; Li Sun, Qiang Zhou, Su Yan, Ming Xiu, Rong-Li Piao, Yan-Hang Gao, Run-Ping Gao, Department of Hepatic-Biliary-Pancreatic Medicine, First Hospital, Jilin University, Changchun 130021, Jilin Province, China. Department of Nephrology and Rheumatology Children's Hospital of Fudan University Shanghai China Department of Anesthesiology, The Seventh Medical Center of PLA General Hospital, Beijing 100700, China. Department of Biomedical Sciences, Florida State University College of Medicine, Tallahassee, Florida, USA Department of Gynecology and Obstetrics, The 980th Hospital of the Joint Logistic Support Force of the Chinese People's Liberation Army, Shijiazhuang, Hebei 050082, P.R. China Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210028, China; Jiangsu Provincial Academy of Traditional Chinese Medicine, Nanjing 210028, China Department of Respiratory Medicine, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China Department of Physics and Tsinghua-Foxconn Nanotechnology Research Center; Tsinghua University; Beijing 100084, China Department of Oncology, Shengjing Hospital of China Medical University, Shenyang 110022, China. The Mount Sinai Bone Program, Mount Sinai School of Medicine, New York, NY 10029; Obstetrics and Gynecology Hospital Fudan University Shanghai China Department of Rheumatology, Children's Hospital of Fudan University, Shanghai, China. lillysun@263.net Department of Dermatology, Central Hospital of Shengli Oil Field, Shandong, People's Republic of China Department of Urology the First Affiliated Hospital of Nanjing Medical University Nanjing Jiangsu P. R. China Department of Experimental Surgery, The Second Affiliated Hospital of Air Force Medical University, Xi’an, Shaanxi Province, China; Department of Anesthesiology, The Second Affiliated Hospital of Air Force Medical University, Xi’an, Shaanxi Province, China Jiangsu Center for Drug Screening Department of Reproductive Medical Center Guangdong Women and Children Hospital Guangzhou China From the Department of Neurology (A.L., S.H., C.Z., J.A., W.Z., L.S., A.H., R.V.), University Heidelberg, Heidelberg, Germany; the Department of Internal Medicine (M.Z., P.N.), University Heidelberg, Heidelberg, Germany; and the Department of Hygiene and Medical Microbiology (A.D.), University Heidelberg, Heidelberg, Germany. Bone Program and Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029; Departments of Pathology and of Physiology and Cell Biology, University of Pittsburgh, and Pittsburgh Veterans Administration Healthcare System, Pittsburgh, PA 15260; and Bronx Veterans Affairs Medical Center, New York, NY 10463 The First Affiliated Hospital of Wenzhou Medical University Key Laboratory of Spin Electron and Nanomaterials of Anhui Higher Education Institutes, School of Chemistry and Chemical Engineering, Suzhou University, Suzhou 234000, People's Republic of China Division of Cardiovascular Medicine, Kobe University Graduate School of Medicine. The Mount Sinai Bone Program Department of Medicine Icahn School of Medicine at Mount Sinai New York New York USA Institute of Crystal Materials; Center for Optics Research and Engineering of Shandong University; Jinan 250100; P. R. China State Key Laboratory of Plant Physiology and Biochemistry, College of Life Sciences Zhejiang University Hangzhou 310058 China Department of Histology and Embryology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China Sichuan Center for Disease Control and Prevention, Chengdu, People's Republic of China Institute of Clinical Epidemiology, Key Laboratory of Public Health Safety (Ministry of Education), School of Public Health, Fudan University, Shanghai 200032, China. Department of Gynecological Oncology, Qingdao Central Hospital, The Second Affiliated Hospital of Medical College of Qingdao University, Qingdao, China. School of Medicine, Jiangsu University, Zhenjiang, Jiangsu, People's Republic of China School of Chemical Engineering, Northwest University, Xi'an 710069, Shaanxi, China Faculty of Basic Medical Sciences, Guilin Medical University, Guilin, Guangxi 541004, P.R. China SUGEN, Inc., 230 E. Grand Avenue, South San Francisco, California 94080 Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029;; Mount Sinai Bone Program, Icahn School of Medicine at Mount Sinai, New York, NY 10029; State Key Laboratory for Managing Biotic and Chemical Threats to Quality and Safety of Agro-Products, Institute of Horticulture, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, China Department of Neurology, China Rehabilitation Research Center, Beijing, China (mainland). MOE Key Laboratory of Cluster Science, School of Chemistry and Chemical Engineering Beijing Institute of Technology Beijing 102488 P.R. China Beijing Key Laboratory of Materials Utilization of Nonmetallic Minerals and Solid Wastes; National Laboratory of Mineral Materials; School of Materials Sciences and Technology; China University of Geosciences (Beijing); Beijing, China Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029; Mount Sinai Bone Program, Mount Sinai School of Medicine, New York, New York Department of Endocrinology, Zhongnan Hospital of Wuhan University, Wuhan 430071, China Emergency Department, Shanxi Provincial People’s Hospital, Xi'an, Shaanxi, China §Department of Clinical Research, Singapore General Hospital, Singapore 169608; State Key Laboratory of Physical Chemistry of Solid Surfaces, College of Chemistry and Chemical Engineering, Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province, Xiamen University, Xiamen 361005, China School of Medicine Jiangsu University Zhenjiang Jiangsu China Center for Skeletal Aging, Veterans Affairs Medical Center, and Department of Medicine, Medical College of Pennsylvania School of Medicine, Philadelphia 19104;; Departments of Medicine and Geriatrics, Mount Sinai School of Medicine, and Bronx Veterans Affairs Geriatrics Research, Education, and Clinical Center, New York, New York, 10029; Graduate School, Tianjin Medical University, Tianjin, PR China National Laboratory of Solid‐State Microstructures School of Electronic Science and Engineering Key Lab of Optoelectronic Devices and Systems with Extreme Performances and Collaborative Innovation Center of Advanced Microstructures Nanjing University Nanjing 210093 China Mount Sinai Bone Program,; Department of Medicine, and Department of Proctology, Yongchuan Hospital of Traditional Chinese Medicine, Chongqing Medical University, Chongqing, China From the Departments of Neurology (R.V., D.A.S., L.S., S.S., S.N., M.S.), Neuroradiology (S.H.), and Physiology (K.B., H.M.), Ruprechts-Karls-University Heidelberg, Germany. Peking University Sixth Hospital / Institute of Mental Health Beijing China Department of Digestive Surgery, Honghui Hospital, Xi’an Jiaotong University Department of Cardiology The First Affiliated Hospital (Key Laboratory of Cardiac Diseases and Heart Failure) Harbin Medical University Harbin China Jiangsu Key Laboratory of Drug Screening and Jiangsu Center for Pharmacodynamics Research and Evaluation, China Pharmaceutical University, Nanjing, P.R. China College of Chemistry and Chemical Engineering; Shaoxing University; Shaoxing; China; School of Materials Science and Chemical Engineering Department of Rheumatology and Immunology The First Affiliated Hospital of Wenzhou Medical University Wenzhou 325000 China Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals, Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, Henan 453007, P. R. China Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen 518116, China School of Medicine, Jiangsu University, Zhenjiang, Jiangsu, China State Key Laboratory of Cancer Biology and Xijing Hospital of Digestive Diseases, Fourth Military Medical University of China, Xi'an, Shaanxi Province, China. Department of Occupational Disease, Taian City Central Hospital Branch, Taian, Shandong, China Department of Respiratory and Critical Care Medicine The Fourth Affiliated Hospital of Zhejiang University School of Medicine Yiwu Zhejiang China Department of Orthopedics Guizhou Provincial People's Hospital Guiyang Guizhou 550000 China Department of Pharmacy, People's Hospital of Xinjiang Uygur Autonomous Region;; Institute of Clinical Pharmacy, People's Hospital of Xinjiang Uygur Autonomous Region; The College of Pharmacy Anhui University of Chinese Medicine Hefei China Zhejiang Academy of Agricultural Sciences Hangzhou 310021 P. R. China Department of Microbiology Swedish University of Agricultural Science Uppsala BioCenter P.O. Box 7025 SE‐750 07 Uppsala Sweden Department of Hepatic, Biliary Pancreatic Medicine First Hospital of Jilin University Changchun China SUGEN, Inc., 230 East Grand Avenue, South San Francisco, California 94080-4811, and Skirball Institute of Biomolecular Medicine and Department of Pharmacology, New York University Medical Center, New York, New York 10016 Department of Neurology, Tianjin Medical University General Hospital, Tianjin 300052, China. Email: sunli_2000@hotmail.com. State Key Laboratory of Tea Plant Biology and Utilization, School of Tea and Food Sciences and Technology, Anhui Agricultural University, Hefei 230036, China; The College of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China State Key Laboratory of New Ceramics and Fine Processing; School of Materials Science and Engineering; Tsinghua University; Beijing 100084; China Department of Urology, Nanjing Medical University First Affiliated Hospital, Nanjing, Jiangsu, China (mainland) Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing 210009, China Jiangsu Key Laboratory of Drug Screening China Pharmaceutical University Nanjing China School of Arts and Design, Yanshan University, Qinhuangdao, China Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China State Key Laboratory of Physical Chemistry of Solid Surfaces, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, People’s Republic of China Department of Respiratory and Critical Care Medicine, The Fourth Affiliated Hospital of Zhejiang University School of Medicine, Yiwu, Zhejiang, China School of Medicine Hangzhou Normal University 310012 Hangzhou China Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, PR China; Function Laboratory for Marine Biology and Biotechnology, Qingdao National Oceanography Laboratory, Qingdao, PR China Department of Basic Medicine, Liaoning University of Traditional Chinese Medicine, Shenyang 110847, China. Department of Pharmacy, The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, China Merck Research Laboratories, West Point, Pennsylvania, 19486, United States Division of Physics and Applied Physics, School of Physical and Mathematical Sciences, Nanyang Technological University, 637371 Singapore Department of Health Services Research and Policy, Faculty of Public Health and Policy, London School of Hygiene and Tropical Medicine, London, UK. Wolfson Institute of Population Health, Barts CRUK Cancer Centre, Queen Mary University of London, London, UK. Division of Cardiovascular Medicine, Kobe University Graduate School of Medicine, Kobe, Japan Mount Sinai Bone Program and Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029 Department of Dermatology and Venereology Nanjing Medical University Affiliated Wuxi People’s Hospital Wuxi China Department of Laboratory Medicine Jinshan Branch of Shanghai 6th People's Hospital Affiliated to Shanghai Jiaotong University Shanghai China Peking University Sixth Hospital/Institute of Mental Health, National Clinical Research Center for Mental Disorders, Beijing, China; Key Laboratory of Mental Health, Ministry of Health (Peking University), Beijing, China State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China. Department of Health Care Center Shandong Provincial Hospital affiliated to Shandong University Jinan 250021 China Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing, Jiangsu 210009, P.R. China From the Department of Nuclear Medicine, 1st Hospital of Harbin Medical University; Department of Administration, Harbin Medical University; and Department of Nuclear Medicine, 4th Hospital of Harbin Medical University, Harbin, China. Department of Gynecological Oncology, Qingdao Central Hospital, The Second Affiliated Hospital of Qingdao University, Qingdao; Department of Gynecological Oncology From the Departments of Neurology (L.S., W.Z., R.P., R.V.), Neuroradiology (S.H.), and Internal Medicine I (M.Z.), Ruprecht-Karls-University Heidelberg, Germany. Department of Radiology, Guang'anmen Hospital of China Academy of Chinese Medical Sciences, Beijing 100053, China. Faculty of Materials Science and Engineering, Kunming University of Science and Technology , Kunming 650093, China School of Civil Engineering, Shenyang Jianzhu University, Shenyang 110168, China Ward of VIP, Shaanxi People’s Hospital, Xi’an 710068, China Department of Radiology Guang'anmen Hospital, China Academy of Chinese Medical Sciences Beijing China SUGEN, Inc., 351 Galveston Drive, Redwood City, California 94063 National Engineering Research Center for Efficient Utilization of Soil and Fertilizer Resources, College of Resources and Environment, Shandong Agricultural University, Tai’an, People’s Republic of China Beijing Key Laboratory of Materials Utilization of Nonmetallic Minerals and Solid Wastes, National Laboratory of Mineral Materials, School of Materials Science and Technology, China University of Geosciences, 100083 Beijing, China; Department of Physics and Tsinghua-Foxconn Nanotechnology Research Center, Tsinghua University, Beijing 100084, China CAS Key Laboratory of Magnetic Materials and Devices Key Laboratory of Additive Manufacturing Materials of Zhejiang Province Division of Functional Materials and Nanodevices Ningbo Institute of Materials Technology and Engineering Chinese Academy of Sciences 1219 Zhong‐guan West Road, Zhen‐hai District Ning‐bo Zhe‐jiang 315201 P. R. China Department of Clinical Research, Singapore General Hospital, Singapore Jiangsu Key Laboratory for Drug Screening China Pharmaceutical University Nanjing China Department of Applied Physics The Hong Kong Polytechnic University Hong Kong China Department of Respiratory Medicine, Zaozhuang Municipal Hospital, Zaozhuang, China State Key Laboratory of Natural Medicines, Center for Drug Discovery, China Pharmaceutical University, 211198 Nanjing, China; Department of Radiation Oncology, The Affiliated Cancer Hospital of Nanjing Medical University & Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research, Nanjing, China Department of Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang, China. University of Science and Technology of China Department of Respiration, Shanxi Province People's Hospital, Xi'an, Shanxi 710068, P.R.China. Anesthesia and Operation Center, Chinese PLA General Hospital, Beijing 100853, P.R. China

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http://rdf.ncbi.nlm.nih.gov/pubchem/reference/34871058
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/26361986
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/9983892
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/23760330
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/9455441
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/30999375
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/28932230
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/10147221
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/26360507
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/16280374
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/29661860
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/34599633
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/205884308
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/34347537
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/36174093
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/35503391
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/18258042
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/29153056
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/5838556
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/31192542
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/35185304
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/18885408
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/14057131
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/18168808
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/28343951
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/7463165
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/28472978
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/23566649
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/32154601
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/5944766
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/13430935
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/9521817
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/30410651
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/34487611
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/211794396
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/12839082
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/7401836
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/14723037
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/12909911
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/4012527
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/33087239
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/663063
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/24327149
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/6728393
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/35968323
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/530749
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/3226284
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/9457795
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/3150245
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/35036018
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/4756817
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/36746934
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/35329122
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/3959979
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/25520287
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/23503341
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/33546097
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/26268144
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/30451030
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/3110689
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/3707751

Total number of triples: 3326.