http://rdf.ncbi.nlm.nih.gov/pubchem/author/MD5_8a041d35e381b427c8059ed870cf731b
Outgoing Links
Predicate | Object |
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family-name | Yang Zhang Zhang |
name | Yang Zhang |
given-name | Yang |
organization-name | School of Electronic and Information Engineering, Beijing Jiaotong University, Beijing 100044, China Department of Ophthalmology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China Center for Plant Science Innovation University of Nebraska‐Lincoln Lincoln NE 68588 USA School of Biological SciencesThe University of Hong KongHong KongChina From the Departments of Physiology and Pharmacology (Y. Zheng, Q.H., A.M., Y. Zhang, Y.P., L.X., Junjia Tang, Jiping Tang, J.H.Z.), and Neurosurgery (J.H.Z.), Loma Linda University School of Medicine, Loma Linda, CA; and Department of Physiology, Medical School of Yangtze University, Jingzhou, Hubei, China (Y. Zheng). Integration Application Center, Institute of Computing Technology, Chinese Academy of Sciences. Molecular Medicine Research Center Beijing Lu Daopei Institute of Hematology Beijing China Rehabilitation Center, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China Department of Ultrasound in Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai Institute of Ultrasound in Medicine, Shanghai, P.R. China Key Laboratory of Green Chemistry and Technology (Ministry of Education); College of Chemistry; Sichuan University; Chengdu 610064, PR China Center for Immunology and Microbial Disease, Albany Medical College, Albany, New York, USA From the *Department of Radiology, Weill Medical College of Cornell University, New York, NY; †Department of Radiology, Qilu Hospital, Shandong University, Jinan, China; ‡Department of Nephrology, Weill Medical College of Cornell University; and §Department of Radiology, Columbia College of Physicians and Surgeons, New York, NY. Key Laboratory of Wooden Materials Science and Engineering of Jilin Province, Beihua University, Jilin City 132013, China; Key Laboratory for the Structure and Function of Polysaccharides in Traditional Chinese Medicine, Beihua University, Jilin City 132013, China Department of Physical Education Shandong Jianzhu University Jinan Shandong China National Special Superfine Powder Engineering Research Center, School of Chemistry and Chemical Engineering, Nanjing University of Science and Technology, Nanjing 210094, China From the Department of Neurosurgery (J.W., G.C.), the First Affiliated Hospital of Soochow University, Suzhou, China; and Department of Physiology (J.W., Y.Z., P.Y., B.E., A.M., J.T., W.J.P., R.H., A.O., J.H.Z.), School of Behavioral Science (R.H.), Department of Pediatrics (A.O.), and Department of Anesthesiology (J.H.Z.), Loma Linda University, CA. Department of Pharmacology (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), College of Pharmacy, Harbin Medical University, Heilongjiang, China (Y.Y., Y.Z., J.Y., M.Z., T.T., Y.J., X.L., G.X., X.L., X.Z., S.L., X.H., Z.L., Y.G., L.Z., H.B., Z. Zhou, J.S., G.Y., L.X., H.S., Y.L., B.Y., Z.P.). University of Houston, College of Pharmacy, Department of Pharmacological & Pharmaceutical Sciences, Houston, TX, USA. Key Laboratory of Eco-Environment-Related Polymer Materials, College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070, China 4Prelude Therapeutics, Wilmington, DE Department of Urology, Jiangsu Provincical Hospital of Traditional Chinese Medicine, Nanjing University of Traditional Chinese Medicine, Nanjing, Jiangsu 210029, China. Key Laboratory of Medical Molecular Virology, Department of Medical Microbiology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, PR China Department of Ultrasound, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, P.R. China State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Fujian 361102, China Department of Neurosurgery, Peking University First Hospital; and Department of Entomology, Nanjing Agricultural University, Xuanwu District, Nanjing, China Department of Pharmacy, Tongji Hospital of Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei China Department of Chemistry Rutgers University 73 Warren Street Newark NJ 07102 USA Massachusetts Institute of Technology 1 Department of Nuclear Science and Engineering, , Cambridge, Massachusetts 02139, USA ByteDance Inc, Beijing, China Department of Mathematical Sciences, New Jersey Institute of Technology, Newark, United States Cancer Centre, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, P.R. China Department of Epidemiology, School of Public Health, Air Force Medical University, Xi’an, Shaanxi, PR China; Shaanxi Energy Institute, College of nursing, Xi’an, China; Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment. Department of Neurosurgery, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China School of Materials Science and Engineering, University of Science and Technology Beijing, Beijing 100083, China Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing 100084, China Department of Neurosurgery, Jining No. 1 People's Hospital Department of Pharmacy, Tongji Hospital of Tongji Medical College Huazhong University of Science and Technology 13 Hangkong Road Wuhan Hubei 430030 China Department of Speech-Language-Hearing Science & Center for Neurobehavioral Development, University of Minnesota, Minneapolis Sun Yat-Sen University Key Laboratory for Polymeric Composite and Functional Materials of Ministry of Education, Key Laboratory of High Performance Polymer-based Composites of Guangdong Province, GBRCE for Functional Molecular Engineering, School of Chemistry CHINA Department of Neurosurgery, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine University of Science and Technology of China Hefei Anhui P.R. China; Department of Neurosurgery Anhui Provincial Hospital Affiliated to Anhui Medical University Hefei Anhui P.R. China School of Biology and Food Engineering Changshu Institute of Technology Changshu 215500 Jiangsu China 1 Department of Medical School, Center for Computational Medicine and Bioinformatics, University of Michigan, 100 Washtenaw Avenue, Ann Arbor, MI 48109 and 2 Department of Molecular Biosciences, Center for Bioinformatics, University of Kansas, 2030 Becker Drive, Lawrence, KS 66047, USA; 1 Department of Medical School, Center for Computational Medicine and Bioinformatics, University of Michigan, 100 Washtenaw Avenue, Ann Arbor, MI 48109 and 2 Department of Molecular Biosciences, Center for Bioinformatics, University of Kansas, 2030 Becker Drive, Lawrence, KS 66047, USA Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology & Visual Sciences Key Lab, Beijing Ophthalmology Institute, Beijing 100730, China. Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, 48109, United States Department of Emergency State Key Laboratory of Biotherapy West China Hospital and School of Chemical Engineering Sichuan University No. 17 Renmin Nan Road Chengdu 610041 China College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China Shanghai Cancer Center and Institutes of Biomedical Sciences Fudan University Shanghai P. R. China State Key Laboratory of Environment-friendly Energy Materials, National Co-innovation Center for Nuclear Waste Disposal and Environmental Safety, Sichuan Civil-military Integration Institute, School of National Defence & Technology, School of Materials and Chemistry, Southwest University of Science and Technology, Mianyang621010, Sichuan, P. R. China Family Planning Research Institute Center for Reproductive Medicine Tongji Medical College Huazhong University of Science and Technology Wuhan China; Hospital for Reproductive Medicine Affiliated to Shandong University Jinan China Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China Department of Materials Science and Engineering, National University of Singapore, 117575 Singapore; Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China Department of Pesticide Science, Plant Protection College, Shenyang Agricultural University, Shenyang 110161, Liaoning, People’s Republic of China Beijing National Laboratory for Molecular Sciences; CAS Key Laboratory of Analytical Chemistry for Living Biosystems; National Centre for Mass Spectrometry in Beijing; Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China; University of Chinese Academy of Sciences, Beijing 100049, P. R. China Cell Engineering Research Center and Department of Cell Biology, State Key Laboratory of Cancer Biology, Fourth Military Medical University, Xi’an, Shaanxi Province 710032, People's Republic of China Department of Laboratory Medicine, National Center for Cardiovascular Diseases, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China Department of Computational Medicine and Bioinformatics University of Michigan Ann Arbor Michigan USA; Department of Biological Chemistry University of Michigan Ann Arbor Michigan USA Center of Advanced Analysis & Gene Sequencing, Zhengzhou University, Zhengzhou, 450001, China Smart Hybrid Materials (SHMs) Lab, Department of Chemical Sciences and Engineering, Advanced Membranes and Porous Materials Center, King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Kingdom of Saudi Arabia Department of Biomedical Engineering, Tufts University, Medford, Massachusetts, USA. Department of Computational Medicine and Bioinformatics , Ann Arbor, MI, USA; Department of Biological Chemistry, University of Michigan , Ann Arbor, MI, USA Wuhan Hongren Biopharmaceutical Inc. Wuhan China Key Laboratory of Mariculture and Stock Enhancement in North China's Sea, Ministry of Agriculture and Rural Affairs, Dalian Ocean University, Dalian, P. R. China Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Pharmacy, Shanghai Jiao Tong University, No. 800 Dongchuan Road, Minhang District, Shanghai 200240, PR China School of Chemistry and Chemical Engineering, Lanzhou Jiaotong University, Lanzhou, Gansu 730070, China Department of Polymer Science & Engineering and Key Laboratory of Mesoscopic Chemistry of MOE, School of Chemistry & Chemical Engineering, Nanjing University, Nanjing 210093, China College of Management, Xi’an University of Architecture and Technology, Xi’an 710055, China School of Pharmacy, University of Wisconsin—Madison, Madison. BIG Data Center, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China; CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China; College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China Department of Clinical Research, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center , Guangzhou , People’s Republic of China Department of Nuclear, Plasma, and Radiological Engineering, University of Illinois at Urbana—Champaign, Urbana, Illinois 61801, United States; Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana—Champaign, Urbana, Illinois 61801, United States State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics Center for Molecular Imaging and Translational Medicine School of Public Health Xiamen University Xiamen 361102 China; Shen Zhen Research Institute of Xiamen University Shenzhen 518057 China Department of Neurosurgery, Beijing Tiantan Hospital Capital Medical University Beijing China; National Clinical Research Center for Neurological Diseases (China) Beijing China Department of Nursing, Zhangjiagang TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou, China Health Science Center, School of Stomatology, Shenzhen University, Shenzhen, China. Materia Medica Development Group, Institute of Medicinal Chemistry Lanzhou University School of Pharmacy Lanzhou China; School of Pharmaceutical Sciences Chongqing University Chongqing China Department of Analytical Biochemistry, Groningen Research Institute of Pharmacy, University of Groningen, 9713 AV Groningen, The Netherlands; Institute of Biochemistry and Center for Molecular Biosciences Innsbruck, University of Innsbruck, 6020 Innsbruck, Austria; Laboratory of Pediatrics, Section Systems Medicine of Metabolism and Signaling, University of Groningen, University Medical Center Groningen, 9713 AV Groningen, The Netherlands School of Life Sciences, Anhui University, Hefei, Anhui Province, China Department of Otolaryngology, Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China; Key Laboratory of Otolaryngology Head and Neck Surgery (Capital Medical University), Ministry of Education, Beijing 100730, China; Key Laboratory of Molecular Pathology of Head and Neck, Beijing 100730, China College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 401331, China Key Laboratory of Medicinal Chemistry for Natural Resource (Ministry of Education and Yunnan Province); State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan; School of Chemical Science and Technology; Library of Yunnan University; Yunnan University Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing, China (mainland) State Key Laboratory of Cellular Stress Biology School of Life Sciences Xiamen University Fujian 361102 P. R. China Department of Chemical Engineering Michigan Technological University Houghton Michigan 49931 Department of Chemistry Key Laboratory of Biomedical Polymers of Ministry of Education, Wuhan University Wuhan 430072 China State Key Laboratory of Infectious Disease Vaccine Development Xiang An Biomedicine Laboratory & Center for Molecular Imaging and Translational Medicine School of Public Health Xiamen University Xiamen 361102 China Institute of Modern Optics and Tianjin Key Laboratory of Micro‐Scale Optical Information Science and Technology Nankai University Tianjin 300350 China State Key Laboratory of Low Dimensional Quantum Physics and Department of Physics Tsinghua University Beijing 100084 China Department of Vascular Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, P.R. China 1 Department of Biological Chemistry, 2Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA, 3Department of Basic Sciences, University of North Dakota, School of Medicine and Health Sciences, Grand Forks, ND 58203, USA and 4Department of Computer Engineering, Bogazici University, Istanbul, Turkey; 1 Department of Biological Chemistry, 2Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA, 3Department of Basic Sciences, University of North Dakota, School of Medicine and Health Sciences, Grand Forks, ND 58203, USA and 4Department of Computer Engineering, Bogazici University, Istanbul, Turkey College of Forestry Guizhou University Guiyang China Department of Laboratory Medicine; Southwest Hospital; Third Military Medical University (Army Medical University); Chongqing 400038; China Department of Neurosurgery, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310000, China Department of Radiology and Tianjin Key Laboratory of Functional Imaging Tianjin Medical University General Hospital Tianjin China Shilei Liu, Rui Wang, Yang Zhang, Yuan Li, Chao Cheng, Yunjian Pan, Jiaqing Xiang, Yawei Zhang, Haiquan Chen, and Yihua Sun, Fudan University Shanghai Cancer Center, Rui Wang, Yang Zhang, Yuan Li, Chao Cheng, Yunjian Pan, Jiaqing Xiang, Yawei Zhang, and Yihua Sun, Shanghai Medical College, Fudan University; Haiquan Chen, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai; and Shilei Liu, Henan Cancer Hospital, The Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, China Department of Mechanical and Materials Engineering University of Nebraska–Lincoln Lincoln NE 68588‐0656 USA Department of Pathology and Medical Laboratorial Examination, Hebei Yanda LU Dao-Pei Hospital, Langfang 065201, Hebei Province, China. Department of Infectious Diseases, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610072, Sichuan, China; Department of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, Sichuan, China Center for High Pressure Science (CHiPS), State Key Laboratory of Metastable Materials Science and Technology, Yanshan University, Qinhuangdao 066004, China; Key Laboratory of Microstructural Material Physics of Hebei Province, School of Science, Yanshan University, Qinhuangdao 066004, China Department of Chemistry and Chemical Biology Cornell University Ithaca NY 14853 USA Department of Cardiology, Shanghai Ninth Peoples Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China Biomedical Engineering The University of Texas at El Paso El Paso TX Department of Biomedical Engineering , Northwestern University , 2145 Sheridan Rd. , Evanston 60208 , IL , USA Institute of Modern Optics and Tianjin Key Laboratory of Micro-Scale Optical Information Science and Technology, Nankai University grid.22935.3f 0000000405308290 State Key Laboratories for Agro-biotechnology and College of Biological Sciences China Agricultural University 100193 Beijing People’s Republic of China Department of Anesthesiology, Northern Jiangsu People’s Hospital Affiliated to Yangzhou University, Yangzhou City, Jiangsu Province, China Department of Chemistry, KTH Royal Institute of Technology, Teknikringen 30, S-10044, Stockholm, Sweden; Cancer Center The First Affiliated Hospital of Xinjiang Medical University Urumqi China Earth Resources Laboratory, Department of Earth, Atmospheric and Planetary Sciences, Massachusetts Institute of Technology , 77 Massachusetts Avenue, Cambridge, Massachusetts 02139 Cell Engineering Laboratory of Orthopaedic Institute Tianjin Hospital Tianjin China Department of Chemistry and Chemical Biology, 120 Baker Laboratory, Cornell University, Ithaca, New York 14853, and Department of Biochemistry, University of Mississippi Medical Center, 2500 North State Street, Jackson, Mississippi 39216 Department of Biochemistry and Molecular Biology (H.M., Y.Z., Z.L., L.G.), The Third Military Medical University, Chongqing, China, 400038; State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics Center for Molecular Imaging and Translational Medicine School of Public Health Xiamen University Xiamen 361102 P. R. China Department of Pharmacology (State Key Laboratory of Frigid Zone Cardiovascular Disease Key Laboratory of Cardiovascular Research, Ministry of Education) College of Pharmacy Harbin Medical University Harbin Heilongjiang 150086 P. R. China Laboratory of Synthetic Microbiology, School of Chemical Engineering & Technology, Tianjin University, Tianjin, PR China; Key Laboratory of Systems Bioengineering (Ministry of Education), Tianjin University, Tianjin, PR China; SynBio Research Platform, Collaborative Innovation Center of Chemical Science and Engineering, Tianjin, PR China Department of Internal Medicine, First Affiliated Hospital of Heilongjiang University of Chinese Medicine Laboratory of the Second Hospital Attached to Mudanjiang Medical University, , , China; , Mudanjiang Medical University, , , China Third Hospital of Daqing Daqing Heilongjiang China Department of Biomaterials, Radboud University Medical Centre, Nijmegen, The Netherlands Authors' Affiliations: 1Department of Epidemiology and Biostatistics, School of Public Health, Peking University; 2Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Cancer Epidemiology; and 3Department of Pathology, Peking University School of Oncology, Beijing Cancer Hospital & Institute, Beijing, P.R. China College of Food Science and Engineering, Ocean University of China, No. 5 Yushan Road, Qingdao 266003, China Innovative Drug Research and Bioinformatics Group, School of Pharmaceutical Sciences and Chongqing Key Laboratory of Natural Drug Research, Chongqing University, Chongqing 401331, China Department of Physics, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States Zhejiang Academy of Traditional Chinese Medicine, Hangzhou 310000, China Jiangsu Institute of Hematology, The First Affiliated Hospital and Collaborative Innovation Center of Hematology, State Key Laboraotry of Radiation Medicine and Protection, Soochow University, Key Laboratory of Thrombosis and Hemostasis, Ministry of Health, Suzhou, Jiangsu 215006, China; Computational Biology Department,School of Computer Science,Carnegie Mellon University,Pittsburgh,PA University of Chinese Academy of Sciences Department of Computational Medicine and Bioinformatics; University of Michigan; Ann Arbor Michigan 48109 Jiangsu Key Laboratory for Animal Genetic, Breeding and Molecular Design, Yangzhou University, Yangzhou 225009, China State Key Laboratory of Chemistry and Utilization of Carbon Based Energy Resources; College of Chemistry, Institute of Applied Chemistry, Xinjiang University, Urumqi, 830046, Xinjiang, PR China Department of General Surgery, The First Affiliated Hospital of Nanchang University, Nanchang, JX, China Key Laboratory for Evaluation and Utilization of Poultry Genetic Resources, Ministry of Agriculture and Rural Affairs, Yangzhou University, Yangzhou 225009, China Department of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, Virginia; and Department of Pharmacy, The Second Affiliated Hospital, Dalian Medical University , No. 467 Zhongshan Road , Dalian 116000 , China Department of Anesthesiology, Clinical Medical College of Yangzhou University, Northern Jiangsu People's Hospital, Yangzhou, Jiangsu 225001, P.R. China Cell Engineering Research Centre and Department of Cell Biology, State Key Laboratory of Cancer Biology, Fourth Military Medical University, Xi'an 710032, People's Republic of China Department of General Surgery, The General Hospital of The Central Military Theater of The People's Liberation Army, Wuhan, Hubei 430030, P.R. China Department of Industrial Design, Guangdong University of Technology, Guangzhou 510090, China Department of Orthopedics Xijing Hospital, The Fourth Military Medical University Xi'an China School of Materials Science and Engineering, East China Jiao Tong University, Nanchang, Jiangxi, China School of Pharmacy, Hebei Medical University , Shijiazhuang 050017 , China Department of Interventional Radiology, The First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233004, P.R. China Cancer Control Research Program, British Columbia Cancer Research Centre, British Columbia Cancer Agency, Vancouver, BC, Canada V5Z 1L3; School of Population and Public Health, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada V6T 1Z3 Matrix Dynamics Group, Faculty of Dentistry; University of Toronto; Toronto Ontario Canada Department of Pharmacology & Toxicology School of Medicine Virginia Commonwealth University Richmond VA USA; Department of Pharmacological & Pharmaceutical Sciences College of Pharmacy University of Houston Houston TX USA From the Cardiology Division, Department of Medicine (Q.L., Y.Z., X.W., Y.Z., S.K., W.-H.L., K.-W.A., Y.Y.S., C.-W.S., H.-F.T.) and Research Centre of Heart, Brain, Hormone, and Healthy Aging (Q.L., C.-W.S., H.-F.T.), University of Hong Kong, Hong Kong, China; Institute of Medical Biology, Singapore (J.Z.); School of Biomedical Sciences, Chinese University of Hong Kong, Hong Kong, China (F.F.-Y.L.); Central Laboratory of Shenzhen Maternity and Child Healthcare Hospital, Shenzhen, China (H.K.Z.);... Department of Physical Medicine and Rehabilitation, Qilu Hospital of Shandong University, No. 107 Wenhuaxi Road, Jinan, Shandong 250012, China University of Wisconsin School of Pharmacy, Madison, WI, USA State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022 Jilin P. R. China; University of the Chinese Academy of Sciences, Beijing 100049, P. R. China School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, People's Republic of China Shanxi Datong University Center of Laboratory Medicine National Center for Cardiovascular Diseases & Fuwai Hospital Peking Union Medical College & Chinese Academy of Medical Sciences , Beijing China The 3rd Xiangya Hospital of Central South University Research Center of National Health Ministry on Transplantation Medicine Engineering and Technology Changsha Hunan China; Institute of Hepatobiliary Diseases of Wuhan University Zhongnan Hospital of Wuhan University, Transplant Center of Wuhan University, Hubei Key Laboratory of Medical Technology on Transplantation Wuhan Hubei China Department of Anesthesiology, First Affiliated Hospital of Nanchang University, Nanchang, China Center for Medical Information and Statistics, The Third Affiliated Hospital of Chongqing Medical University, Chongqing 401120, China Department of Plastic Surgery, Xiangyang Center Hospital, Xiangyang Hubei, 441000, P.R.China. Key Laboratory for Polymeric Composite and Functional Materials of Ministry of Education and Key Laboratory of High Performance Polymer-Based Composites of Guangdong Province, School of Chemistry, Sun Yat-Sen University, Guangzhou 510006, China National Key Laboratory of Energetic Materials, Xi’an Modern Chemistry Research Institute, Xi’an 710065, People’s Republic of China School of Environment and Guangdong Key Laboratory of Environmental Pollution and Health; Jinan University; Guangzhou 510632; China Department of Orthopedic Surgery, Xijing Hospital, The Air Force Medical University, Xi’an, Shaanxi, China (mainland) Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China. Department of Pharmacy, The Second Affiliated Hospital, Air Force Medical University School of Public Health, Jilin University, Changchun, Jilin 130021, P. R. China Green Fan Manufacturing Collaborative Innovation Center in Hubei Province, Wuchang Institute of Technology, Wuhan, Hubei, 430065, China Department of Chemistry and Institutes of Biomedical Sciences, Fudan University, Shanghai 200433, China Department of Computational Medicine and Bioinformatics University of Michigan Ann Arbor MI USA; Department of Biological Chemistry University of Michigan Ann Arbor MI USA State Key Laboratory of Rare Earth Resource Utilization; Changchun Institute of Applied Chemistry; Chinese Academy of Sciences; Changchun 130022; P. R. China Department of Chemistry, Tsinghua University, 100084, Beijing, People's Republic of China Department of Immunology, Nanjing Medical University, Nanjing, Jiangsu, China. National Key Laboratory of Plant Molecular Genetics, Shanghai Center for Plant Stress Biology, Center of Excellence for Molecular Plant Sciences, Chinese Academy of Sciences, 200032 Shanghai, China;; College of Resources and Environmental Sciences, Nanjing Agricultural University, 210095 Nanjing, China; 1 Institute of Image Processing and Pattern Recognition, Shanghai Jiao Tong University, 2Key Laboratory of System Control and Information Processing, Ministry of Education of China, Shanghai 200240, China, 3Department of Computational Medicine and Bioinformatics and 4Department of Biological Chemistry, University of Michigan, Ann Arbor, MI 48109, USA; 1 Institute of Image Processing and Pattern Recognition, Shanghai Jiao Tong University, 2Key Laboratory of System Control and Information Processing, Ministry of Education of China, Shanghai 200240, China, 3Department of Computational Medicine and Bioinformatics and 4Department of Biological Chemistry, University of Michigan, Ann Arbor, MI 48109, USA National Engineering Lab for Textile Fiber Materials and Processing Technology Zhejiang Sci‐Tech University Hangzhou 310018 P. R. China; Zhejiang Provincial Innovation Center of Advanced Textile Technology Zhejiang Sci‐Tech University Shaoxing 312000 P. R. China Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, National Center for Nanoscience and Technology (NCNST), Beijing, 100083, P. R. China College of Veterinary Medicine, Sichuan Agricultural University, Wenjiang, Chengdu, China Department of Experimental Pharmacology and Toxicology, School of Pharmacy, Jilin University, Changchun 130021, P. R. China Chongqing Key Laboratory for Oral Diseases and Biomedical Sciences Chongqing Municipal Key Laboratory for Oral Biomedical Engineering of Higher Education Stomatological Hospital of Chongqing Medical University Chongqing China Department of Cell Biology, National Translational Science Center for Molecular Medicine, Fourth Military Medical University, Xi'an, Shaanxi 710032, P.R. China Center for Bioinformatics and Department of Molecular Bioscience, University of Kansas, 2030 Becker Dr, Lawrence, KS 66047, USA School of Dentistry, Health Science Center, Shenzhen University, Shenzhen, China.; School of Biomedical Engineering, Health Science Center, Shenzhen University, Shenzhen, China. Department of Hematology, Tianjin Medical University General Hospital, Tianjin 300052, China. 1Key Laboratory of Medical Molecular Virology and Department of Medical Microbiology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, PR China 3Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital and Institute, Beijing, China. Key Laboratory of Oil Crops in Huanghuaihai Plain, Ministry of Agriculture, PR China,Henan Provincial Key Laboratory for Oil Crops Improvement, Zheng Zhou, PR China State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, CAS, Beijing 100190, China; School of Life Science and Technology, Henan Institute of Science and Technology, Xinxiang, Henan 453003, China Hefei National Laboratory for Physical Sciences at the Microscale and Synergetic Innovation Center of Quantum Information and Quantum Physics, University of Science and Technology of China , Hefei, Anhui 230026, China Sichuan Industrial Institute of Antibiotics, Chengdu University, Chengdu, China School of the Environment, and State Key Laboratory of Pollution Control and Resource Reuse, Nanjing University, 163 Xianlin Avenue, Nanjing, Jiangsu 210023, China Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, United States Department of Neurosurgery The Third People's Hospital of Chengdu Chengdu China Department of Anesthesiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China Minhang Hospital and Institutes of Biomedical Sciences, Fudan University, Shanghai, China Comprehensive Technical Service Center of Xuzhou Customs, Xuzhou Customs, Xuzhou 221000, China School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China; State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China State Key Laboratory of Cellular Stress Biology Innovation Center for Cell Signaling Network School of Life Sciences Xiamen University Fujian 361102 China State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine School of Public Health Xiamen University Xiamen 361102 China Diabetes Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland Department of Molecular Biology, University of Duisburg-Essen, Hufelandstrasse 55, D-45122 Essen, Germany National Institute on Drug Dependence Peking University Beijing China; Department of Pharmacology, School of Basic Medical Sciences Peking University Health Science Center Beijing China Institutes of Biomedical Sciences, Department of Chemistry, School of Life Sciences, and Zhongshan Hospital, Fudan University, 130 DongAn Road, Shanghai 200032, China Division of Abdominal Cancer, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Collaborative Innovation Centre for Biotherapy, Chengdu, China From the Departments of Clinical Developmental Sciences (A.R.A.), and Cardiac and Vascular Sciences (Y.P.D., A.W., Y.Z.), St George’s University of London, London, UK; the Cardiovascular Division (Q.X.), King’s College London, London, UK; the Department of Neurology (S.K., M.R., J.W.), Medical University of Innsbruck, Innsbruck, Austria; and the Departments of Internal Medicine (S.W.), and Laboratory Medicine (A.M.), Bruneck Hospital, Bruneck, Italy. Department of Oncology The Second Hospital of Dalian Medical University Dalian Liaoning People's Republic of China Institute of Molecular Biology, University of Duisburg-Essen, Essen, Germany Biomedical Engineering; The University of Texas at El Paso; El Paso; USA Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Cancer Epidemiology, Peking University School of Oncology Peking University Cancer Hospital & Institute Beijing China Department of Otolaryngology‐Head and Neck Surgery, Beijing Tongren Hospital Capital Medical University Beijing China; Key Laboratory of Otolaryngology Head and Neck Surgery Capital Medical University Beijing China; Department of Head and Neck Surgery The University of Texas MD Anderson Cancer Center Houston Texas State Key Laboratory of Oncology in South China, Guangzhou 510060, China. National Engineering Lab for Textile Fiber Materials & Processing Technology Zhejiang Sci-Tech University Hangzhou 310018 P. R. China; Zhejiang Provincial Innovation Center of Advanced Textile Technology Shaoxing 312000 P. R. China CAS Key Laboratory of Environmental Biotechnology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China; University of Chinese Academy of Sciences, Beijing, China Key Laboratory of Superlight Materials and Surface Technology Ministry of Education College of Materials Science and Chemical Engineering Harbin Engineering University Harbin 150001 China College of Stomatology, China Medical University, Shengyang 110002, China. xzf7090@yahool.com.cn. Department of Ophthalmology, Ruijin Hospital Affiliated Medical School, Shanghai Jiaotong University, Shanghai, China Department of Stomatology, The Air Force Hospital From Eastern Theater , Nanjing , People’s Republic of China Department of Cardiology, Guizhou Provincial People's Hospital, Guiyang, Guizhou 550002, P.R. China Institute of Orthopadics and Traumatology, the First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310053,China Department of Pharmacology and Toxicology, School of Medicine, Virginia Commonwealth University, Richmond, VA, 23298. Hefei National Laboratory for Physical Sciences at the Microscale and Synergetic Innovation Center of Quantum Information & Quantum Physics, University of Science and Technology of China, Hefei, Anhui 230026, China Department of Genetics and Cell Biology, Frontiers Science Center for Cell Responses, Tianjin Key Laboratory of Protein Sciences, College of Life Sciences, Nankai University , Tianjin, 300071 , People’s Republic of China Key Laboratory for Polymeric Composite and Functional Materials of Ministry of Education, Key Laboratory of High-Performance Polymer-based Composites of Guangdong Province, School of Chemistry, Sun Yat-sen University, Guangzhou 510006, People’s Republic of China TEDA Institute of Biological Sciences and Biotechnology, Nankai University, Tianjin, People’s Republic of China School of Electronic and Information Engineering, Beijing Jiaotong University, Beijing, 100044, China Department of Computational Medicine and Bioinformatics, University of Michigan Ann Arbor Michigan; Department of Biological Chemistry, University of Michigan Ann Arbor Michigan Laboratory of Veterinary Pathology and Public Health, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China Key Laboratory of Animal Genetics and Breeding and Molecular Design of Jiangsu Province Yangzhou University Yangzhou China College of Chemistry, The Key Laboratory of Chemical Biology and Organic Chemistry of Henan Province, Zhengzhou University, Zhengzhou 450052, P. R. China School of Biology and Food Engineering; Changshu Institute of Technology; Changshu 215500; China Cell Engineering Research Center & Department of Cell Biology, State Key Laboratory of Cancer Biology, National Key Discipline of Cell Biology, Fourth Military Medical University, Xi'an, China State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen 361102, China Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, and Shanghai Institute of Infectious Disease and Biosecurity, Fudan University, Shanghai, People’s Republic of China Laboratory for Molecular Photonics, Department of Chemistry, University of Miami, 1301 Memorial Drive, Coral Gables, Florida 33146-0431, United States Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA Hefei National Laboratory for Physical Sciences at the Microscale and Synergetic Innovation Center of Quantum Information and Quantum Physics, University of Science and Technology of China, Hefei 230026, China Department of Geriatric Respiratory and Sleep, The First Affiliated Hospital of Zhengzhou University Zhengzhou 450052, Henan, China. Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, United States Key Laboratory of Molecular Microbiology & Technology, Ministry of Education, Tianjin Economic-Technological Development Area, Tianjin, PR China; TEDA Institute of Biological Sciences & Biotechnology, Nankai University, Tianjin Economic-Technological Development Area, Tianjin, PR China; Tianjin Key Laboratory of Microbial Functional Genomics, Tianjin Economic-Technological Development Area, Tianjin, PR China Institute of Biotechnology and Food Science, Hebei Academy of Agricultural and Forestry Sciences, Shijiazhuang 050051, China; Key Laboratory of Plant Genetic Engineering Center of Hebei Province, Shijiazhuang 050051, China School of Chemistry and Chemical Engineering and ‡Key Laboratory of Energy Material Chemistry, Ministry of Education, Institute of Applied Chemistry, Xinjiang University, Urumqi 830046, Xinjiang China Department of Anesthesiology, Medical Center of Anesthesiology and Pain, The 1st Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang 330006, Jiangxi, China Department of Neurobiology and Key Laboratory of Neurodegenerative Diseases of Liaoning Province Jinzhou Medical University Jinzhou China Max Planck Institute for Chemical Physics of Solids, 01187 Dresden, Germany Department of Anesthesiology Tianjin Fourth Central Hospital Tianjin 300142 China Department of Urology, The Second Hospital of Tianjin Medical University; Tianjin Institute of Urology, Tianjin, China. Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, China; Key Laboratory of Otolaryngology Head and Neck Surgery of the Ministry of Education, Beijing, China Department of Physical Medicine & Rehabilitation Qilu Hospital, Shandong University Jinan China Department of Clinical Research State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Sun Yat‐sen University Cancer Center Guangzhou Guangdong P. R. China Beijing National Laboratory for Molecular Sciences, State Key Lab of Rare Earth Materials Chemistry and Applications, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China School of Chemistry and Chemical Engineering Xi'an University of Science and Technology Xi'an 710054 China Center for X-Mechanics, Zhejiang University, Hangzhou 310012, P. R. China; Institute of Applied Mechanics, Zhejiang University, Hangzhou 310012, P. R. China; Key Laboratory of Soft Machines and Smart Devices of Zhejiang Province, Hangzhou 310012, P. R. China 5Department of Pathology, Affiliated Hospital of Jining Medical University, Jining Medical University, Jining, Shandong, China. Yang Zhang, Jian-Xing Luo, Xiao-Yu Hu, Sen Zhong, Department of Infectious Diseases, Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610072, Sichuan Province, China. University of Shanghai for Science and Technology, Shanghai, P.R. China Natural Product Laboratory, Department of Food Science and Technology, Huazhong AgriculturalUniversity, Wuhan, Hubei 430070, People’s Republic of China Division of Orthopaedic Surgery, Department of Orthopaedics, Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong, China Department of Polymer Materials, Zhejiang Sci-Tech University, Hangzhou, Zhejiang 310018, China; National Engineering Laboratory for Textile Fiber Materials and Processing Technology, Hangzhou, Zhejiang 310018, China; Institute of Smart Fiber Materials, Zhejiang Sci-Tech University, Hangzhou, Zhejiang 310018, China State Key Laboratory of Fine Chemicals, Research and Development Center of Membrane Science and Technology, School of Chemical Engineering, Dalian University of Technology, Dalian 116024, China Department of Infectious Diseases, Municipal Hospital of Zaozhuang, Zaozhuang 277100, China. zhangyangziyan@163.com Institute of Hybrid Materials, National Center of International Research for Hybrid Materials Technology, College of Materials Science and Engineering, Qingdao University, Qingdao 266071, China. zyybfq@163.com. 2nd Inpatient Department Binzhou People's Hospital Binzhou China Department of Urology Mianzhu City People's Hospital Mianzhu Sichuan P.R. China University of Michigan 2 Department of Computational Medicine and Bioinformatics, , Ann Arbor, Michigan 45108, USA Department of Hematology Tianjin Medical University General Hospital Tianjin China Department of Oncology , The First Affiliated Hospital, Xinjiang Medical University, Urumqi Xinjiang 830011, China. National Genomics Data Center, Beijing 100101, China; Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100049, China Key Laboratory of Medical Molecular Probes, School of Basic Medical Sciences Xinxiang Medical University Xinxiang Henan 453003 China Department of Gastrointestinal Surgery, First Hospital of Jilin University, Changchun, Jilin province, China School of Agriculture, Henan Institute of Science and Technology, Xinxiang 453003, China; The Genetic Engineering International Cooperation Base of Chinese Ministry of Science and Technology, The Key Laboratory of Molecular Biophysics of Chinese Ministry of Education, College of Life Science and Technology, Huazhong University of Science & Technology, Wuhan 430074, China Beijing Key Laboratory of Applied Experimental Psychology National Demonstration Center for Experimental Psychology Education (Beijing Normal University) Faculty of Psychology Beijing Normal University Beijing China Beijing National Laboratory for Molecular Sciences; CAS Key Laboratory of Analytical Chemistry for Living Biosystems; Beijing Centre for Mass Spectrometry; Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, People’s Republic of China Department of Oncology People's Hospital of Pudong Shanghai China Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853-1301, and Department of Biochemistry, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061-0308 Savaid Medical School, University of Chinese Academy of Sciences, Beijing, China; School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China Key Laboratory of Pesticide & Chemical Biology (CCNU), Ministry of Education, Department of Chemistry, Central China Normal University, Wuhan 430079, China Department of Mechanical and Electrical Engineering, Xiamen University, Xiamen361005, China; Shenzhen Research Institute of Xiamen University, Shenzhen518057, China Uppsala University, Dept. Immunology, Genetics and Pathology, Rudbeck Laboratory, Dag Hammarskjölds väg 20, SE751 85 Uppsala, Sweden Department of Pediatric Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan Wuhan University, Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Diseases of Wuhan University Transplant Center of Wuhan University, Hubei Key Laboratory of Medical Technology on Transplantation Wuhan, Hubei; Research Center of National Health Ministry on Transplantation Medicine Engineering and Technology The 3rd Xiangya Hospital of Central South University Changsha China Department of Ultrasound in Medicine Shanghai Jiao Tong University Affiliated Sixth People's Hospital Shanghai 200233 P. R. China; Shanghai Institute of Ultrasound in Medicine Shanghai Jiao Tong University Affiliated Sixth People's Hospital Shanghai 200233 P. R. China Department of Cardiology, Shanghai Deji Hospital, Shanghai, 200331, China Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education/Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College Heilongjiang University of Chinese Medicine Harbin 150040, China. College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China; State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China; Key Laboratory of Preventive Veterinary Medicine in Hubei Province, Huazhong Agricultural University, Wuhan, China Department of Neurology, West China Hospital, Sichuan University, No. 37, Wainan Guoxue Xiang, Chengdu 610041, Sichuan, China Department of Speech-Language-Hearing Sciences and Center for Neurobehavioral Development, University of Minnesota, Minneapolis Department of Radiation Oncology, Yantai Yuhuangding Hospital Affiliated to Qingdao University Medical College, Yantai, Shandong 264000, P.R. China Department of the 7th General Surgery and 1st Breast Surgery, Shengjing Hospital of China Medical University, Shenyang 110022, People’s Republic of China. Ministry of Education Key Laboratory of Cell Activities and Stress Adaptations, School of Life Sciences, Lanzhou University, Lanzhou, China Department of Medical Oncology The Second Affiliated Hospital Dalian Medical University Dalian China Institutes of Biomedical Sciences and Department of Chemistry, 130 DongAn Road, Fudan University, Shanghai 200032, China Center for High Pressure Science (CHiPS), State Key Laboratory of Metastable Materials Science and Technology, Yanshan University, Qinhuangdao 066004, PR China; Key Laboratory for Microstructural Material Physics of Hebei Province, School of Science, Yanshan University, Qinhuangdao 066004, PR China Department of Clinical Laboratory, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China Department of Biochemistry, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China 3Department of Laboratory Medicine, Guangdong Provincial People's Hospital, Guangzhou, China Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Provincial Key Laboratory of Applied Marine Biology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, China; South China Sea Bio-Resource Exploitation and Utilization Collaborative Innovation Center, Guangzhou, China; Hainan Provincial Key Laboratory of Tropical Marine Biology Technology, Sanya Institute of Oceanology Chinese Academy of Sciences, Tropical Marine Biological Research Station in Hainan, Chinese Academy of Sciences, Sanya, China State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen 361102, P. R. China Information Center of Science and Technology, Shanghai Innovation Center of TCM Health Service, Shanghai University of Traditional Chinese Medicine, Shanghai (201203), China State Key Laboratory for Agrobiotechnology, College of Biological Sciences China Agricultural University Beijing 100193 P. R. China; France‐China Bio‐mineralization and Nano‐structure Laboratory Beijing 100193 P. R. China Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology Department of Energy and Petroleum Engineering University of Stavanger 4036 Stavanger Norway; Beyonder AS Kanalsletta 2 4033 Stavanger Norway Institutes of Biomedical Sciences, Fudan University, Mingdao Bldg. 815, 138 Yixueyuan Road, Shanghai 200032, China Department of Tumor Cell Biology, St. Jude Children’s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA Department of Health Sciences and Technology; ETH Zurich; Ch-8093 Zurich; Switzerland Department of Laboratory Medicine, Fuwai Hospital, National Centre for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China Department of Biochemistry & Biophysics, Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA; Nutrition Graduate Program, School of Biological & Population Health Sciences, College of Public Health & Human Sciences, Oregon State University, Corvallis, OR 97331, USA Beijing Institute of Hepatology Beijing Youan Hospital, Capital Medical University Beijing China The School of Communication Engineering, Hangzhou Dianzi University, Hangzhou 310018, P.R.China. Key Laboratory of Theoretical and Computational Photochemistry Ministry of Education College of Chemistry Beijing Normal University Beijing 100875 China Department of Speech-Language-Hearing Sciences and Center for Neurobehavioral Development, University of Minnesota 4 , Minneapolis, Minnesota 55455, USA Department of Pharmacological & Pharmaceutical Sciences College of Pharmacy University of Houston Houston Texas Lab of Innovative Drug Research and Bioinformatics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China; Innovative Drug Research and Bioinformatics Group, School of Pharmaceutical Sciences and Collaborative Innovation Center for Brain Science, Chongqing University, Chongqing 401331, China Tianjin Orthopedic Research Institute Tianjin China Department of Laboratory Diagnostics, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China Department of Polymer Materials; Zhejiang Sci Tech University; Hangzhou 310018; China; National Engineering Laboratory for Textile Fiber Materials and Processing Technology (Zhejiang) CAS Key Laboratory of Tropical Marine Bio-resources and Ecology and Guangdong Provincial Key Laboratory of Applied Marine Biology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China School of Life Science and Technology, Henan Institute of Science and Technology, Henan, 453003, China Tsinghua Laboratory of Brain and Intelligence (THBI) and Department of Biomedical Engineering, Tsinghua University, Beijing, P.R. China Department of Molecular and Medical Pharmacology, Crump Institute for Molecular Imaging (CIMI), California NanoSystems Institute (CNSI), University of California, Los Angeles, California 90095, United States Department of Computational Medicine & Bioinformatics, University of Michigan , Ann Arbor, MI 48109, USA Department of Biochemistry, Duke University Medical Center, Durham, NC 27710 School of Materials and Energy, Guangdong University of Technology, Guangzhou 510006, China Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, Virginia. Department of Metabolic Biology, John Innes Center, Norwich NR4 7UH, United Kingdom;, Beijing Tongren Hospital, Capital Medical University, No. 1 Dongjiaomin Lane, Dongcheng District, Beijing 100730, China Department of Physiology and Pharmacology, Loma Linda University School of Medicine, CA, USA Department of Computational Medicine and Bioinformatics, University of Michigan, 100 Washtenaw Avenue, Ann Arbor, MI, 48109-2218, USA. zhng@umich.edu. Department of Biological Chemistry, University of Michigan, 100 Washtenaw Avenue, Ann Arbor, MI, 48109-2218, USA. zhng@umich.edu. Department of Neurology, Center for Human Genetics Research Vanderbilt Brain Institute, Vanderbilt University School of Medicine Nashville TN Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA. zhng@umich.edu. Istituto Italiano di Tecnologia (IIT), Via Morego 30, 16163 Genova, Italy Beijing National Laboratory for Molecular Sciences; CAS Key Laboratory of Analytical Chemistry for Living Biosystems; National Centre for Mass Spectrometry in Beijing; Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China Chinese Academy of Sciences Key Laboratory of Pathogenic Microbiology and Immunology and Key Laboratory of Microbial Physiological and Metabolic Engineering, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China;; University of Chinese Academy of Science, Beijing 100149, China; Aerospace Balance Medical Center, Chinese PLA Air Force Medical Center, Beijing, China School of Materials Science and Engineering, Wuhan University of Technology, Wuhan, 430070, China Department of Orthopedic Lu'an Fourth People's Hospital Lu'an Anhui China Department of Chemistry and Biochemistry, Texas Tech University, Box 41061, Lubbock, Texas 79423-1061 Division of Pathology & Laboratory Medicine Hebei Yanda Lu Daopei Hospital Langfang China Innovative Drug Research and Bioinformatics Group, School of Pharmaceutical Sciences, Chongqing University, Chongqing 401331, China School of Biology and Food Engineering, Changshu Institute of Technology, Changshu 215500, China Department of Plastic Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China. Department of Polymer Materials; Zhejiang Sci Tech University; Hangzhou 310018; China Research Center for Analytical Sciences; College of Sciences; Northeastern University; Shenyang 110189; China Engineering Research Center of Electronic Information Materials and Devices (Ministry of Education) Guangxi Key Laboratory of Information Materials School of Materials Science and Engineering Guilin University of Electronic Technology Guilin Guangxi 541004 P. R. China Hunan Institute of Advanced Sensing and Information Technology Xiangtan University Hunan 411105 China CAS Key Laboratory of Design and Assembly of Functional Nanostructures; Fujian Provincial Key Laboratory of Nanomaterials; Fujian Institute of Research on the Structure of Matter; Chinese Academy of Sciences; Xiamen 361021 Department of Anesthesiology, First Affiliated Hospital of Nanchang University, Nanchang, China. Department of Health Statistics, School of Preventive Medicine, Fourth Military Medical University From the Department of Pharmacology (The Key Laboratory of Cardiovascular Research, Ministry of Education) at College of Pharmacy (B.C., Yang Zhang, Y. Zhao, J.W., T.L., Yiyuan Zhang, Y.J., X.J., G.X., P.L., Yilin Sun, Q.H., X.Z., W.S., Y.Y., Yangyang Sun, L.S., X.L., Y.L., B.Y., Z.P.), Harbin Medical University, China. The College of Architecture and Civil Engineering; Beijing University of Technology; Beijing; China Department of Orthopaedics, Zhejiang Provincial Hospital of Traditional Chinese Medicine, Hangzhou 310006, Zhejiang, China. Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana−Champaign, Urbana, Illinois 61801, United States; Department of Nuclear, Plasma, and Radiological Engineering, University of Illinois at Urbana−Champaign, Urbana, Illinois 61801, United States China Rehabilitation Research Center for Hearing and Speech Impairment, Beijing, China; Department of Chemistry and Biochemistry, Miami University, Oxford, Ohio 45056, United States Key Laboratory of Advanced Civil Engineering Materials; Ministry of Education; School of Materials Science & Engineering; Tongji University; Shanghai 201804 1Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Cancer Epidemiology, Peking University Cancer Hospital and Institute, Beijing, China. State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, People’s Republic of China; University of Chinese Academy of Sciences, Beijing 100049, People’s Republic of China Department of Gastroenterology The Second Affiliated Hospital of Chengdu Medical College, Nuclear Industry 416 Hospital Chengdu Sichuan Province China Shanghai Electrochemical Energy Devices Research Center; School of Chemistry and Chemical Engineering and State Key Laboratory of Metal Matrix Composites; Shanghai Jiao Tong University; Shanghai; P. R. China Hubei Key Laboratory of Animal Nutrition and Feed Science, Hubei Collaborative Innovation Center for Animal Nutrition and Feed Safety, Wuhan Polytechnic University, Wuhan, China Key Laboratory of Chemical Biology and Organic Chemistry of Henan Province, College of Chemistry, Zhengzhou University, Zhengzhou 450052, China Laboratory for Molecular Photonics, Department of Chemistry, University of Miami, Coral Gables, FL, United States; Department of Biomedical Engineering, Northwestern University, Evanston, IL, United States. Department of Pharmacology and Toxicology, School of Pharmacy, Jilin University, Changchun 130021, China Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China Department of Laboratory Medicine, National Center for Cardiovascular Disease Chinese Academy of Medical Sciences & Peking Union Medical College Fuwai Hospital Beijing China The Second Hospital of Anhui Medical University,Hefei,China Cancer Research Institute, School of Medicine, University of South China, China Key Laboratory of Low Dimensional Materials and Application Technology of Ministry of Education, School of Materials Science and Engineering, Xiangtan University, Xiangtan 411105, People’s Republic of China Department of Chemistry and Biochemistry, Texas Tech University, Box 41061, Lubbock, Texas 79409-1061 robert.flowers@ttu.edu Authors' Affiliations: Departments of 1Thoracic Surgery and 2Pathology, Fudan University Shanghai Cancer Center; 3Department of Oncology, Shanghai Medical College, Fudan University; 4Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institute for Biological Science, Chinese Academy of Science; and 5Promed Cancer Centers, Shanghai, China; Authors' Affiliations: Departments of 1Thoracic Surgery and 2Pathology, Fudan University Shanghai Cancer Center; 3Department of Oncology, Shanghai Medical College, Fudan University; 4Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institute for Biological Science, Chinese Academy of Science; and 5Promed Cancer Centers, Shanghai, China Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials Department of Chemistry Fudan University 2205 Songhu Road Shanghai 200438 China Nanotechnology and Intestinal Microecology Research Center Shanghai Tenth People's Hospital, School of Medicine Tongji University Shanghai China; Precision Medicine Center Taizhou Central Hospital Taizhou Zhejiang China The Department of Molecular and Cellular Physiology (X.M., Y.Z., A.S., J.V., P.R., L.E.), Diabetes Research Unit, Institute of Physiological Sciences, BMC B11, SE-221 84 Lund, Sweden Department of Chemical Engineering, Institute of Polymer Science and Engineering, Tsinghua University, Beijing 100084, China Department of Chemical Engineering, Process Engineering for Sustainable Systems, KU Leuven, W. de Croylaan 46, B-3001 Leuven, Belgium; Separation and Conversion Technology, Flemish Institute for Technological Research (VITO), Boeretang 200, B-2400 Mol, Belgium *Department of Immunology, State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, Jiangsu 211166, China; and School of Biology and Food Engineering Changshu Institute of Technology Changshu Jiangsu China Department of Neurosurgery, West China Hospital, Sichuan University; Department of Radiology, West China Hospital, Sichuan University State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China; and Key Laboratory of Preventive Veterinary Medicine in Hubei Province, The Cooperative Innovation Center for Sustainable Pig Production, Wuhan, China Department of Plastic & Laser Cosmetology, Hunan Provincial People’s Hospital & The First Affiliated Hospital of Hunan Normal University, Changsha, Hunan, China Microelectronics Research Center, The University of Texas at Austin, 10100 Burnet Road, Bldg. 160, Austin, Texas 78758, United States Department of Cardiology, Shanghai Ninth People’s Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200011, China; Department of Cardiology, Shanghai Deji Hospital, Qingdao University, Shanghai 200331, China Key Laboratory of Advanced Technologies of Materials, Ministry of Education, School of Chemistry, Southwest Jiaotong University, Chengdu, Sichuan 610031, P R China Department of Applied Physics, Xi’an Jiaotong University, Xi’an 710049, China Shanghai Municipality Key Laboratory of Veterinary Biotechnology, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, People's Republic of China Department of Ophthalmology, Peking Union Medical College Hospital, Peking Union Medical College, Eye Research Center of Chinese Academy of Medical Sciences, Beijing 100730, China. ICU Center; First Affiliated Hospital; Heilongjiang University of Chinese Medicine; Harbin 150040; China SCNU‐TUE Joint Lab of Device Integrated Responsive Materials (DIRM) National Center for International Research on Green Optoelectronics South China Normal University No. 378, West Waihuan Road, Guangzhou Higher Education Mega Center Guangzhou 510006 China Innovative Institute of Chinese Medicine and Pharmacy, Academy for Interdiscipline, Chengdu University of Traditional Chinese Medicine , Chengdu, China Department of Neurosurgery The First Affiliated Hospital of Jilin University Changchun Jilin China Department of Laboratory Medicine Hongqi Hospital of Mudanjiang Medical University Mudanjiang Heilongjiang China Department of Respiratory Medicine, First Affiliated Hospital, Guangxi Medical University, Nanning 530021, China. Jiangsu Key Laboratory of Environmentally Friendly Polymeric Materials, School of Materials Science and Engineering, Jiangsu Collaborative Innovation Center of Photovoltaic Science and Engineering, Changzhou University, Changzhou 213164, Jiangsu, P.R. China College of Agriculture, Guangxi University, Nanning, China Institute of Biomedical Sciences, Fudan University, Shanghai 200433, China Sichuan University Key Laboratory of Bio-resource and Eco-environment of Ministry of Education, College of Life Sciences, , Chengdu, 610065, China Department of Otorhinolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Key Laboratory of Otorhinolcryngology Head and Nech Surgery, Ministry of Education, Beijing 100730, China. State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, 38 Xueyuan Road, Beijing 100191, China Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences Chongqing China; Stomatological Hospital of Chongqing Medical University Chongqing China School of Physics, Southeast University, Nanjing 211189, China Department of Materials Science and Engineering, National University of Singapore, 117575, Singapore Key Laboratory of Medical Molecular Probes, Department of Medical Chemistry, School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang 453003, China Department of Respiratory Medicine, First Affiliated Hospital of Soochow University Suzhou, Jiangsu, P. R. China. School of Biological Sciences, The University of Hong Kong, Pokfulam, Hong Kong. Department of Endocrinology and Metabolism, Affiliated Hospital of Weifang Medical University, Weifang, China; Clinical Research Center, Affiliated Hospital of Weifang Medical University, Weifang, China Department of Clinical Research Sun Yat‐sen University Cancer Center State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Guangzhou China Department of Biomedical Engineering, Shenzhen University, Shenzhen, 518037, P. R. China Department of Gastroenterology, Digestive Disease Hospital The First Affiliated Hospital of Nanchang University Nanchang China Department of Hematology, Lu Daopei Hospital, Langfang, Hebei 065201, China Department of Radiological Sciences Tu & Yuen Center for Functional Onco‐Imaging. University of California Irvine California USA Key Laboratory of Semiconductor Materials Science, Chinese Academy of Sciences, Beijing 100083, P. R. China School of Physics, Southeast University, Nanjing 211189, China. State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen 361102, China *Center of Excellence in Bioinformatics, University at Buffalo, State University of New York, 901 Washington Street, Buffalo, NY 14203; and Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China Department of Oncology, Second Affiliated Hospital of Dalian Medical University, Dalian, PR China Department of Nuclear Science and Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, NIST Center of Neutron Research, National Institute of Standard and Technology, Gaithersburg, Maryland, Department of Materials Science and Engineering, University of Maryland, College Park, Maryland, and Department of Chemistry, National Taiwan University, Taipei, Taiwan 106 College of Instrumentation and Electrical Engineering, Jilin University 1 , Ximin Zhu Street, Changchun 130061, China; Key Laboratory of Geo-Exploration Instruments, Ministry of Education of China 2 , Changchun 130061, China Institute of Combined Traditional Chinese and Western Medicine, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China Department of Biochemistry, Zhongshan School of Medicine, Sun Yat-sen University, and Department of Medicine, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, PR China. State Key Laboratory of Polymer Physics and Chemistry Institute of Chemistry Chinese Academy of Sciences Beijing 100190 China; University of Chinese Academy of Sciences Beijing 100049 China Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, National Clinical Research Center for Digestive Disease, Beijing Digestive Disease Center, Beijing Key Laboratory for Precancerous Lesion of Digestive Disease, Beijing, China; Department of Materials Science and Engineering, National University of Singapore, Singapore 117575, Singapore; Instrumental Analysis Center of Xi’an Jiaotong University, Xi’an Jiaotong University, Xi’an 710049, China State Key Laboratory of Rice Biology and Breeding, Ministry of Agriculture Key Laboratory of Molecular Biology of Crop Pathogens and Insects, Key Laboratory of Biology of Crop Pathogens and Insects of Zhejiang Province, Institute of Biotechnology, Zhejiang University, Hangzhou 310058, China Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, Texas. Department of Dermatology, The First Affiliated Hospital of Baotou Medical College Inner Mongolia University of Science and Technology Baotou China Department of Clinical Research, Sun Yat‐Sen University Cancer Center, State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Guangzhou Guangdong China; Research Unit of Precision Diagnosis and Treatment for Gastrointestinal Cancer Chinese Academy of Medical Sciences Guangzhou Guangdong P. R. China Department of Biomechanics, Orthopaedic Research Institute Tianjin Hospital Tianjin China Department of Otorhinolaryngology, Head and Neck Surgery, Beijing Tong Ren Hospital Capital Medical University Beijing China; Key Laboratory of Otorhinolaryngology, Head and Neck Surgery Beijing Institute of Otorhinolaryngology Beijing China Department of Chemistry Fudan University 220 Handan Road Shanghai 200433 P.R. China Department of Pharmacy Beijing Friendship Hospital Capital Medical University Beijing China Department of Molecular and Medical Pharmacology University of California at Los Angeles Los Angeles California Department of Chemistry South China University of Technology Guangzhou 510640 People's Republic of China Key Laboratory for Evaluation and Utilization of Poultry Genetic Resources of Ministry of Agriculture and Rural Affairs Yangzhou China Department of Respiratory Medicine the First Affiliated Hospital of Soochow University Suzhou China; Suzhou Key Laboratory for Respiratory Diseases Suzhou China Department of Neurosurgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing; and State Key Laboratory of Biocontrol and Guangdong Key Laboratory of Plant Resources School of Life Sciences Sun Yat–sen University 510275 Guangzhou China School of Biological Science and Medical Engineering, Key Laboratory for Biomechanics and Mechanobiology, Beihang Univeristy, Beijing 100083, China Department of Chemistry; KTH – Royal Institute of Technology; Stockholm; Sweden Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA 23298, USA; Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX 77204, USA State Key Laboratory of Catalysis, 2011-Collaborative Innovation Center of Chemistry for Energy Materials, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian116023, People’s Republic of China College of Chemistry, Key Laboratory of Theoretical & Computational Photochemistry of Ministry of Education Beijing Normal University Beijing 100875 China Center for Population and Development Studies, Renmin University of China , Beijing , China Department of Research and Development, Sinotech Genomics Inc., Shanghai, China Department of Hepatobiliary Surgery, The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang City, China. Department of Oncology, Xiangyang Central Hospital, Medical College, Hubei University of Arts and Science Xiangyang, Hubei 441000, P.R. China. Consultant for Biopharma Companies, New York, USA Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, P.R. China School of Public Health, Jilin University, Changchun, Jilin, P. R. China Shanghai Key Laboratory of Chemical Biology School of Pharmacy East China University of Science and Technology Shanghai China Department of Computer and Information Science, University of Macau, Macau, China Department of Surgical Oncology, Tangshan People's Hospital, Tangshan, Hebei, China. From the State Key Laboratory of Medical Molecular Biology, Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, P.R. China (Y.-F.Y., J.-F.P., Y.Z., R.Z., F.W., P.G., Z.-Q.Z., T.-T.W., Z.-G.S., H.-Z.C, D.-P.L.); and Key Laboratory of Tumor Molecular Biology, Department of Biochemistry and Molecular Biology, Binzhou Medical University, YanTai, ShanDong, P.R. China (Y.-F.Y.). University of Birmingham Medical School, Birmingham, United Kingdom Ophthalmology Department, First affiliated hospital of Kunming Medical University, Kunming State Key Laboratory of Multiphase Flow in Power Engineering, Xi’an Jiaotong University, Xi’an 710049, China; Nuclear and Radiation Safety Center, Beijing 100082, China Department of Biomaterials Radboud University Medical Centre P.O. Box 9101 6500 HB Nijmegen The Netherlands School of History and Culture, Hubei University, Wuhan 430062, China; School of Chemistry and Chemical Engineering, Hubei Key Laboratory of Coal Conversion and New Carbon Materials, Wuhan University of Science and Technology, Wuhan 430081, China; Jingzhou Conservation Center, 108 Jingbei Road, Jingzhou 434020, China Innovative Institute of Chinese Medicine and Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China Pharmacy School of Jilin University, Changchun, Jilin 130021, China. AVIC Composite Corporation Ltd., Beijing 101300, China Department of Pathology, Peking University Health Science Center, Beijing 100191, China. State Key Laboratory of Biobased Material and Green Papermaking, Key Laboratory of Pulp and Paper Science & Technology of Ministry of Education/Shandong Province, Key Laboratory of Pulp, Paper, Printing & Packaging of China National Light Industry, Key Laboratory of Green Printing & Packaging Materials and Technology in Universities of Shandong Province, School of Light Industry Science and Engineering, School of Chemistry and Pharmaceutical Engineering, Qilu University of Technology (Shandong Academy of... The Key Laboratory of Resource Chemistry of Ministry of Education, Shanghai Key Laboratory of Rare Earth Functional Materials, and Shanghai Municipal Education Committee Key Laboratory of Molecular Imaging Probes and Sensors, Shanghai Normal University, Shanghai 200234, China Department of Pharmacology Key Laboratory of Cardiovascular Medicine Research, Ministry of Education; State‐Province Key Laboratories of Biomedicine‐Pharmaceutics of China, Harbin Medical University Harbin Heilongjiang People's Republic of China Institute of Nephrology, Zhong Da Hospital, Southeast University School of Medicine, Nanjing City, Jiangsu Province, China From the Institute of Vascular Medicine, Li Ka Shing Institute of Health Sciences, and School of Biomedical Sciences, Chinese University of Hong Kong, Hong Kong SAR, China (X.Y.T., W.T.W., Y.L., Y.Z., L.W., W.S.C., X.Y., Y.H.); Department of Medicine (A.X.) and Department of Pharmacology and Pharmacy (A.X., Y.W.), University of Hong Kong, Hong Kong SAR, China. Department of Gastroenterology, the Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou, Henan, China Department of Hematology, Tianjin Medical University General Hospital, Heping, Tianjin 300052, P.R. China Department of Systems Biology for Medicine, and Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai 200032, China Department of Orthopedics, Xinqiao Hospital, Third Military Medical University, Chongqing, People's Republic of China Department of Head and Neck Surgery the University of Texas MD Anderson Cancer Center Houston TX; Department of Otolaryngology Head and Neck Surgery Beijing Tongren Hospital, Capital Medical University, Key Laboratory of Otolaryngology Head and Neck Surgery Capital Medical University, Ministry of Education Beijing China Department of Cardiac Surgery, The First Affiliated Hospital of Nanchang University, Nanchang, China. Department of Clinical Research, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, China College of Biological and Environmental Sciences, Zhejiang Wanli University, Ningbo 315100, China Department of Medical Laboratory Guangdong General Hospital Guangdong Academy of Medical Science Guangzhou China Bayer AG, Research & Development, Pharmaceuticals Wuppertal/Leverkusen Germany Department of Neurosurgery, The First Hospital of Jilin University, Changchun, Jilin, China Jiangsu Key Laboratory of Advanced Materials and Technology; School of Petrochemical Engineering; Changzhou University; Changzhou; China Lenovo Research Beijing China National Special Superfine Powder Engineering Research Center School of Chemistry and Chemical Engineering Nanjing University of Science and Technology Nanjing 210094 China State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics Center for Molecular Imaging and Translational Medicine School of Public Health Xiamen University Xiamen 361102 China 1 Institute of Image Processing and Pattern Recognition, Shanghai Jiao Tong University, and Key Laboratory of System Control and Information Processing, Ministry of Education of China, Shanghai 200240, China and 2Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA Department of Physics, University of Science and Technology of China, Hefei, Anhui 230026, People's Republic of China Department of Infectious Diseases, Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610072, Sichuan, China National Energy R&D Center for Biorefinery, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China; Beijing Key Laboratory of Bioprocess, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China Department of Gastrointestinal Surgery, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China Department of Experimental Pharmacology and Toxicology, School of Pharmacy, Jilin University, 1266 Fujin Road, Changchun, Jilin 130021, China Department of Anesthesiology, Tianjin Fourth Center Hospital, Tianjin 300140, P.R. China Computer Science and Engineering in 2015 fromNorthwestern Polytechnical University, China Department of Neurology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing 210008, China; Department of Neurology, Nanjing Drum Tower Hospital, State Key Laboratory of Pharmaceutical Biotechnology and Institute of Translational Medicine for Brain Critical Diseases, Nanjing University, Nanjing 210008, China Key Laboratory of Medicinal Chemistry for Natural Resources (Ministry of Education and Yunnan Province); School of Chemical Science and Technology; Yunnan University; Kunming 650091; China Department of Chemistry, University of Utah, 315 South 1400 East, Salt Lake City, Utah 84112 Department of Obstetrics & Gynecology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China. Email: zhangyang@coga.org.cn. Dept. of Pharmacy, Tongji Hospital of Tongji Medical College Huazhong Univ. of Science and Technology 13 Hangkong Road Wuhan Hubei China Institute of Vascular Medicine, Li Ka Shing Institute of Health Sciences, School of Biomedical Sciences, Chinese University of Hong Kong, Hong Kong SAR, China. Department of Physics Massachusetts Institute of Technology Cambridge MA 02139 USA Department of General Surgery, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China Department of Pharmacy, Tongji Hospital of Tongji Medical College, Huazhong University of Science & Technology, 13 Hangkong Road, Wuhan, Hubei 430030, China National Center for Electron Microscopy in Beijing, School of Materials Science and Engineering, The State Key Laboratory of New Ceramics and Fine Processing, Key Laboratory of Advanced Materials (MOE), Tsinghua University, Beijing 100084, P.R. China Centre for Lipid Research & Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, Department of Infectious Diseases, the Second Affiliated Hospital, Chongqing Medical University, Chongqing, China. Department of Orthopaedics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China. The State Key Laboratory of Physical Chemistry of Solid Surfaces, Fujian Provincial Key Laboratory of Theoretical and Computational Chemistry, iChEM, and College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, Fujian 361005, China School of Physics, Dalian University of Technology, Dalian 116024, China Neurosurgery,Yangzhou Hongquan Hospital, Yangzhou 225200, Jiangsu, China 2Department of Biochemistry and Molecular BiologyIndiana University School of Medicine, Indianapolis, Indiana, USA Rehabilitation Center, Qilu Hospital of Shandong University, Jinan, Jinan 250012, P. R. China Physicochemical Group of College of Criminal Science and Technology & Forensic Center of Public Security of Bureau of National Forestry Bureau, Nanjing Forest Police College, Nanjing 210023, China Key Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, China Department of Respiratory Medicine, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, P.R. China Department of Histology and Embryology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology , Wuhan , China Canadian Economic Analysis Department, Bank of Canada Ottawa Ontario Canada Department of Molecular and Medical Pharmacology; Crump Institute for Molecular Imaging (CIMI); California NanoSystems Institute (CNSI); University of California; Los Angeles CA 90095-1770 USA National Special Superfine Powder Engineering Research Center of China Nanjing University of Science and Technology Nanjing Jiangsu 210094 P. R. China Department of Neurosurgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310000, P.R. China Electron Microscopy for Materials Science (EMAT) University of Antwerp Groenenborgerlaan 171 Antwerp 2020 Belgium; NANOlab Center of Excellence University of Antwerp Groenenborgerlaan 171 Antwerp 2020 Belgium Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University; Key Laboratory of Thrombosis and Hemostasis, Ministry of Health; Collaborative Innovation Center of Hematology, Soochow University, Suzhou 215006, Jiangsu Province, China. Neuroscience Research Institute and Department of Neurobiology, Peking University Health Science Center, Beijing, China Department of Vascular Surgery, Beijing Chao Yang Hospital, Affiliate of Capital Medical University, Beijing, People's Republic of China e Tianjin Orthopedic Hospital, Tianjin 300211, P. R. China Henan Tumor Research Institute, Zheng Zhou, Henan 450000, People’s Republic of China; Central Hospital, Nan Yang, Henan 473000, People’s Republic of China; People’s First Hospital of Nan Yang, Nan Yang, Henan 473000, People’s Republic of China; and Laboratory for Cancer Research, Department of Chemical Biology, College of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854-8020 Molecular Medicine Center Beijing Lu Daopei Institute of Hematology Beijing China; Division of Pathology & Laboratory Medicine Hebei Yanda Lu Daopei Hospital Langfang China School of Energy and Power Engineering, Xi’an Jiaotong University, Xi’an 710049, China No.598, Heping West Road, Shijiazhuang, China.Shijiazhuang, China, 050051; Qingdao University Medical College Affiliated Yantai Yuhuangding Hospital, Yantai, China Department of Geriatric Cardiology, National Clinical Research Center for Geriatric Diseases, 2nd Medical Center, Chinese PLA General Hospital, Beijing, China; and Department of Radiological Sciences University of California Irvine California USA National Energy R&D Center of Biorefinery, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China Sichuan Engineering Research Center for Biomimetic Synthesis of Natural Drugs, School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, People’s Republic of China State Key Laboratory of Tea Plant Biology and Utilization; Anhui Agricultural University; Hefei 230036; China Frontiers Science Center for Flexible Electronics Xi'an Institute of Flexible Electronics (IFE) and Xi'an Institute of Biomedical Materials & Engineering Northwestern Polytechnical University 127 West Youyi Road Xi'an 710072 China Department of Laboratory Medicine, Chongqing University Cancer Hospital, Chongqing 400038, China Department of Orthopaedic Surgery, Nanfang Hospital, Guangdong Province - China College of Chemistry, Beijing Normal University, 100875, Beijing, China Jilin Ginseng Academy Changchun University of Chinese Medicine Changchun 130117 China Anhui Agricultural University, Hefei, China The State Key Laboratory of Polymer Materials Engineering Sichuan Provincial Engineering Laboratory of Plastic/Rubber Complex Processing Technology Polymer Research Institute of Sichuan University Chengdu 610065 China The Second Department of Breast Surgery, Tangshan People's Hospital, Tangshan, Hebei 063000, P.R. China Department of Immunology and Microbial Disease, MC-151, Albany Medical College, 47 New Scotland Avenue, Albany, NY 12208–3479, USA Department of Respiratory The First Affiliated Hospital of Zhengzhou University Zhengzhou China 1Cell Engineering Research Centre and Department of Cell Biology, State Key Laboratory of Cancer Biology and Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, USA; Department of Biological Chemistry, University of Michigan, Ann Arbor, USA School of Clinical Medicine, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China Jilin Provincial Center for Disease Control and Prevention, Changchun, China; Computational Medicine & Bioinformatics University of Michigan Ann Arbor MI 48109 USA From the Departments of Neurosurgery (Y.C., H.F.) and Neurology (C.L.), Southwest Hospital, Third Military Medical University, Chongqing, China; and Department of Physiology and Pharmacology, Loma Linda University, CA (Y.C., Y.Z., J.T., F.L., Q.H., J.T., J.H.Z.). Nanomedicine and Intestinal Microecology Research Center, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai 200072, China; Precision Medicine Center, Taizhou Central Hospital, 999 Donghai Road, Taizhou, Zhejiang 318000, China Jiangsu Province Key Laboratory of Anesthesiology, Jiangsu Province Key Laboratory of Anesthesia and Analgesia Application Technology, NMPA Key Laboratory for Research and Evaluation of Narcotic and Psychotropic Drugs, Xuzhou Medical University, 209 Tongshan Rd, Xuzhou, Jiangsu 221004, China Cancer Control Research Program British Columbia Cancer Research Centre British Columbia Cancer Agency Vancouver British Columbia Canada 3Department of Guangzhou Blood Center, Guangzhou, China. The Research Center for Medical Genomics and MOH Key Laboratory of Cell Biology, China Medical University, Shenyang, China. Key Laboratory for Aerosol-Cloud-Precipitation of China Meteorological Administration, Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters, Nanjing University of Information Science & Technology, Nanjing 210044, China. Department of Cardiology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing Department of Orthopedics, Second Hospital of Shanxi Medical University, Taiyuan, China Department of Nephrology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China; Department of Anesthesiology and Perioperative Medicine, The Second Hospital of Anhui Medical University, Hefei, Anhui, China (mainland) Key Laboratory of Saline-alkali Vegetation Ecology Restoration (Northeast Forestry University), Ministry of Education , Harbin 150040 , China; College of Life Sciences, Northeast Forestry University , Harbin 150040 , China Department of Emergency, Renji Hospital, Shanghai Jiao Tong University School of Medicine, 2000 Jiangyue Road, Minhang District, Shanghai, 200025, China Laboratory of Atmospheric Physico-Chemistry, Anhui Institute of Optics and Fine Mechanics, Chinese Academy of Sciences, Hefei 230031, Anhui, China Department of Anesthesiology, The First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233003, P.R. China School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, People’s Republic of China College of Mechanical and Electrical Engineering, Qingdao University, 308 Ningxia Road, Qingdao266071, China Center for Smart Materials and Devices; State Key Laboratory of Advanced Technology for Materials Synthesis and Processing; Wuhan University of Technology; Wuhan 430070; China BIG Data Center, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China; CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100049, China school of data science, Fudan University, China John Innes Centre Norwich Research Park NR4 7UH Norwich UK †Department of Computational Medicine and Bioinformatics, University of Michigan School of Medicine, Ann Arbor, MI 48109; and Department of endocrinology, Shengli Clinical Medical College of Fujian Medical University, Fuzhou, China; Department of Endocrinology, Fujian Provincial Hospital, Fuzhou, China Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853-1301, and Departments of Cellular and Molecular Physiology and Pharmacology, Milton S. Hershey Medical Center, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033 Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde Foshan), Foshan 528308, China State Key Laboratory of Optoelectronic Materials and Technology, Guangdong Provincial Key Laboratory of Low Carbon Chemistry and Process Energy Conservation, School of Materials Science and Engineering, Sun Yat-sen University, Guangzhou 510275, P. R. China State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics Center for Molecular Imaging and Translational Medicine School of Public Health Xiamen University Xiamen Fujian 361005 China College of Chemical and Biological Engineering; Lanzhou Jiaotong University; Lanzhou; China Department of Biopharmacy, School of Pharmaceutical Sciences, Jilin University, Changchun, Jilin 130022, P.R. China Department of Anesthesiology, Northern Jiangsu People's Hospital Affiliated to Yangzhou University/Clinical Medical College, Yangzhou University, Institute of Anesthesia, Emergency and Critical Care of Northern Jiangsu People's Hospital, Yangzhou 225001, Jiangsu, China. Corresponding author: Gao Ju, Email: gaoju_003@163.com. State Key Laboratory of Biotherapy and Cancer Center, and Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu 610041, China Department of Orthopedics, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, P.R. China Department of Anesthesiology The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University Huai'an Jiangsu China Divison of Pathology & Laboratory Medicine Hebei Yanda Lu Daopei Hospital Langfang China Institute of Environment and Sustainable Development in Agriculture, Chinese Academy of Agriculture Sciences, Beijing 100081, China. The Department of Physical Medicine and Rehabilitation, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan 250012, P. R. China Department of Endocrinology, Peking University First Hospital, Beijing, China Department of Sports Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, China National Genomics Data Center & CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China; China National Center for Bioinformation, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100049, China Department of Biomaterials Radboudumc Nijmegen the Netherlands State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Beijing, China. Department of Breast Surgery, Xingtai People’s Hospital of Hebei Medical University, Xingtai, Hebei, People’s Republic of China Center for X-Mechanics and Institute of Applied Mechanics, Zhejiang University, Hangzhou 310027, P. R. China Instrumental Analysis Center Xi'an Jiaotong University Xi'an 710049 China Hand Surgery Department, Central Hospital Affiliated to Shen Yang Medical Collage, Shenyang 110024, Liaoning Province, China University of Minnesota Department of Speech-Language-Hearing Sciences and Center for Neurobehavioral Development, , Minneapolis, Minnesota 55455 zhang470@umn.edu Anhui University, School of Life Sciences, Center for Stem Cell and Translational Medicine, Hefei, Anhui Province, P. R. China Caltech Optical Imaging Laboratory Andrew and Peggy Cherng Department of Medical Engineering California Institute of Technology Pasadena CA 91125 USA School of Chemistry and Chemical Engineering Shanghai Jiao Tong University Shanghai 200240 China Department of Bioinformatics, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China Key Laboratory of Medicinal Chemistry for Natural Resource (Ministry of Education and Yunnan Province), School of Chemical Science and Technology, and Yunnan University Library, Yunnan University, 2 North Cuihu Road, Kunming 650091, China Department of Oncology, Shanghai Medical College Fudan University Shanghai China; Department of Thoracic Surgery Fudan University Shanghai Cancer Center Shanghai China; Institute of Thoracic Oncology Fudan University Shanghai China; State Key Laboratory of Genetic Engineering, School of Life Sciences Fudan University Shanghai China Department of Thoracic Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang, China. Department of Hepatobiliary Surgery, Taizhou Municipal Hospital Affiliated with Taizhou University, Taizhou, Zhejiang, China Center for Smart Materials and Devices, State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Wuhan 430070, China Department of Pharmacy, Beijing Friendship Hospital Capital Medical University Beijing China Center for Reproductive Medicine and Obstetrics and Gynecology, Nanjing Drum Tower Hospital Nanjing University Medical School Nanjing China; Center for Molecular Reproductive Medicine Nanjing University Nanjing China Department of Breast Surgery, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, China Department of Chemistry and Chemical Biology, Cornell University, 120 Baker Lab, Ithaca, New York 14853, United States Naval Research Academy, Beijing 100161, China State Key Laboratory of Optoelectronics Materials and Technologies and ‡School of Chemistry and Chemical Engineering/MOE Laboratory of Bioinorganic and Synthetic Chemistry, Sun Yat-sen University, Guangzhou 510275, China; Department of Chemistry and ∥Department of Applied Physics, South China University of Technology, Guangzhou 510641, China Institute for Integrative Nanosciences IFW Dresden Helmholtzstraße 20 01069 Dresden Germany Key Laboratory of Semiconductor Materials Science, Institute of semiconductors, Chinese Academy of Sciences, Beijing, China Department of Gastric and Colorectal Surgery, The First Hospital, Jilin University, Changchun, Jilin 130021, P.R. China SCNU-TUE Joint Lab of Device Integrated Responsive Materials (DIRM), National Center for International Research on Green Optoelectronics, South China Normal University, Guangzhou Higher Education Mega Center, No. 378, West Waihuan Road, 510006 Guangzhou, China; Guangdong Provincial Key Laboratory of Optical Information Materials and Technology & Institute of Electronic Paper Displays, South China Academy of Advanced Optoelectronics, South China Normal University, Guangzhou 510006, P. R. China Department of Neurosurgery, The First Affiliated Hospital of Jilin University, Jilin University, Changchun, Jilin 130033, P.R. China Department of Orthopedics, Xinqiao Hospital, Army Medical University, Chongqing 400037, P.R. China College of Chemistry; Key Laboratory of Theoretical & Computational Photochemistry of Ministry of Education; Beijing Normal University; Beijing; China Fudan University, Institutes of Biomedical Sciences, Shanghai, Shanghai, China Department of Nuclear Science and Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139;; Neutron Scattering Science Division and Joint Institute for Neutron Sciences, Oak Ridge National Laboratory, Oak Ridge, TN 37831; Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan 250117, Shandong China Department of Anesthesiology, Tianjin Medical University General Hospital, Tianjin 300054, China. Corresponding author: Xie Keliang, Email: daguang521521@163.com. Institute of Nephrology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, China; and Biomedical Engineering, University of Texas at El Paso, El Paso, Texas, USA Institute of Orthopedics and Traumatology The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Traditional Chinese Medicine) Hangzhou China Department of Medical Oncology State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Sun Yat‐sen University Cancer Center Guangzhou Guangdong 510060 P. R. China Minhang Hospital and Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, China Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Cancer Epidemiology Peking University Cancer Hospital & Institute Beijing China School of Materials Science and Engineering Center of Advanced Analysis & Gene Sequencing Zhengzhou University Zhengzhou 450001 P. R. China School of Materials Science and Engineering, University of Science and Technology Beijing, Beijing 100083, China; Beijing Municipal Key Laboratory of New Energy Materials and Technologies, Beijing 100083, China 1 College of Information Engineering, Northwest A&F University, Yangling 712100, China, 2Department of Biochemistry and Molecular Biology, Monash University, Melbourne, VIC 3800, Australia, 3National Engineering Laboratory for Industrial Enzymes and Key Laboratory of Systems Microbial Biotechnology, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China, 4Centre for Research in Intelligent Systems, Faculty of Information Technology, Monash University, Melbourne, VIC 3800, Australia and 5ARC Centre of Excellence in Advanced Molecular Imaging, Monash University, Melbourne, VIC 3800, Australia Key Laboratory of Advanced Civil Engineering Materials of Ministry of Education; Functional Materials Research Laboratory; School of Materials Science & Engineering; Tongji University; Shanghai 201804 Institute for Immunology and Immunotherapy University of Birmingham Medical School Birmingham UK Department of Oncology, The Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116023, P.R. China Department of Neurology, Drum Tower Hospital, Medical School of Nanjing University, Nanjing, China Department of Radiology, Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai P.R. China School of Public Health (Shenzhen); Sun Yat-sen University; Shenzhen; China Department of Ultrasound in Medicine, Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University, Shanghai 200233, P.R. China Innovative Institute of Chinese Medicine and Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 611137, P.R. China Department of Chemistry and Institutes of Biomedical Sciences Shanghai Medical School Fudan University Shanghai P. R. China Department of Anesthesiology, Clinical Medical College of Yangzhou University, Subei People's Hospital of Jiangsu, Yangzhou, Jiangsu 225001, P.R. China Institute of Medicinal Chemistry, School of Pharmaceutical Science, Lanzhou University State Key Laboratory of Southwestern Chinese Medicine Resources Chengdu University of Traditional Chinese Medicine Chengdu 611137 China Department of Gastroenterology, Changhai Hospital, Second Military Medical University, Shanghai, China; Department of Cancer Biology, University of Texas, MD Anderson Cancer Center, Houston, Texas Dalian Medical University, College of Basic Medical Sciences, Department of Biotechnology The Key Laboratory of Monitoring and Management of Plant Diseases and Insects, Ministry of Agriculture, Nanjing Agricultural University, 1 Weigang Street, Nanjing 210095, China. Department of Chemistry and Institutes of Biomedical Science Shanghai Medical School; Fudan University; Shanghai 200032; China Institute of Modern Optics Nankai University Tianjin 300071 China Institute of Biotechnology, Fuzhou University, Fuzhou 350002, China. zy_94@hotmail.com Biostatistical research methodologist at the BC Cancer Agency. Department of Gastroenterology, The First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine, Harbin, Heilongjiang 150001, P.R. China Key Laboratory of Theoretical & Computational Photochemistry of Ministry of Education College of Chemistry Beijing Normal University Beijing 100875 China Department of Speech–Language–Hearing Sciences & Center for Neurobehavioral Development, University of Minnesota, Twin Cities, MN 55455, USA Smart Hybrid Materials (SHMs) Laboratory, Advanced Membranes and Porous Materials Center, King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Kingdom of Saudi Arabia Department of Polymer Materials, Zhejiang Sci-Tech University, Hangzhou, 310018 China Center of Laboratory Medicine, Beijing Key Laboratory for Molecular Diagnostics of Cardiovascular Diseases State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases & Fuwai Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Beijing China Department of Chemistry, Lehigh University, Bethlehem, Pennsylvania 18015 College of Anesthesia, Xuzhou Medical University, Xuzhou, China 3Department of Geriatric Respiratory and Sleep, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China Department of Rehabilitation Medicine National Key Laboratory of Medical Molecular Biology, Department of Physiology and Pathophysiology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences/School of Basic Medicine, Peking Union Medical College, Beijing 100005, China Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, Wuhan 430074, China ; Key Laboratory of Biomedical Photonics of Ministry of Education, Department of Biomedical Engineering, Huazhong University of Science and Technology, Wuhan 430074, China. Department of Molecular and Medical Pharmacology, Crump Institute for Molecular Imaging (CIMI), California NanoSystems Institute (CNSI), University of California, Los Angeles, 570 Westwood Plaza, Los Angeles, California 90095-1770, United States Polytechnique Montreal,Department of Electrical Engineering,Canada Department of Pharmacy, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China School of Civil & Environmental Engineering, University of Science and Technology, Beijing, Beijing, 100083, China First Affiliated Hospital of Heilongjiang University of Chinese Medicine CAF; National Engineering Laboratory for Biomass Chemical Utilization, Key and Open Laboratory on Forest Chemical Engineering, SFA, Key Laboratory of Biomass Energy and Material, Institute of Chemical Industry of Forest Products, Nanjing, Jiangsu 210042, China Department of Geriatric Cardiology, National Clinical Research Center for Geriatric Diseases, 2nd Medical Center, Chinese PLA General Hospital, Beijing 100853, China Department of Immunology and Microbial Disease, Albany Medical College, Albany, New York, USA Department of Orthopaedics, Xijing Hospital The Fourth Military Medical University Xi’an China Joint Pathology Center , Silver Spring, MD , USA Beijing National Laboratory for Molecular Sciences; CAS Key Laboratory of Analytical Chemistry for Living Biosystems; Beijing Centre for Mass Spectrometry; Institute of Chemistry; Chinese Academy of Sciences Center of Excellence in Bioinformatics, University at Buffalo 901 Washington Street, Buffalo, NY 14203, USA. National Translational Science Center for Molecular Medicine, Department of Cell Biology, Fourth Military Medical University, Xi'an, P.R. China Division of Laboratory Medicine Hebei Yanda Lu Daopei Hospital Langfang China Institute of Modern Optics & Tianjin Key Laboratory of Micro-Scale Optical Information Science and Technology, Nankai University, Tianjin 300071, China Department of Medical Ultrasound and Central Laboratory Nanotechnology and Intestinal Microecology Research Center Shanghai Tenth People's Hospital Tongji University School of Medicine No. 301 Yan‐chang‐zhong Road Shanghai 200072 P. R. China MRC Centre for Immune Regulation, School of Immunity and Infection University of Birmingham Birmingham B15 2TT United Kingdom Department of Medicine; Zhejiang Academy of traditional Chinese Medicine; Hangzhou 310007 Zhejiang China College of Fores-try, Northeast Forestry University, Harbin 150040, China. Hubei Key Laboratory of Animal Nutrition and Feed Science Hubei Collaborative Innovation Center for Animal Nutrition and Feed Safety Wuhan Polytechnic University Wuhan P.R. China Key Laboratory of Biomedical Polymers; Ministry of Education; Department of Chemistry; Wuhan University; Wuhan 430072 Solar Energy Research Institute Yunnan Normal University Kunming 650500 China Department of Ophthalmology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences College of Life Science and Biotechnology, Dalian University, Dalian 116622, China Departments of Thoracic Surgery and State Key Laboratory of Genetic Engineering Fudan University Shanghai Cancer Center Shanghai China; Institute of Thoracic Oncology Fudan University Shanghai China; Department of Oncology Shanghai Medical College, Fudan University Shanghai China Department of Pharmacology, School of Basic Medical Sciences Anhui Medical University Hefei China Institute of Infectious Diseases Beijing Ditan Hospital, Capital Medical University Beijing China Program of Polymer and Color Chemistry, Department of Textile Engineering, Chemistry and Science, North Carolina State University, Raleigh, North Carolina 27606, United States Department of Hygienic Toxicology, College of Public Health, Harbin Medical University, Harbin, Heilongjiang Province, Peoples’ Republic of China North Carolina State University Center of Excellence in Bioinformatics, University at Buffalo, 901 Washington St, Buffalo, NY 14203–1199, USA Center for High Pressure Science (CHiPS), State Key Laboratory of Metastable Materials Science and Technology, Yanshan University, Qinhuangdao 066004, P. R. China; Key Laboratory for Microstructural Material Physics of Hebei Province, School of Science, Yanshan University, Qinhuangdao 066004, P. R. China Department of Chemistry KTH-Royal Institute of Technology Teknikringen 36 10044 Stockholm Sweden Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, USA Department of Cardiology, Taizhou Hospital Affiliated to Wenzhou Medical University, Linhai, 317000 Zhejiang Province, China Department of Materials Science and Engineering National University of Singapore 117575 Singapore Singapore Center of Clinical Laboratory, Zhongshan Hospital Xiamen University Nanjing University Reproductive Medicine Center, the Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, Jiangsu, People’s Republic of China Department of General Surgery, Peking University Third Hospital, Beijing, China. Key Laboratory of Marine Drugs; Ministry of Education & Shandong Provincial Key Laboratory of Glycoscience and Glycotechnology; School of Medicine and Pharmacy; Ocean University of China; Qingdao 266003 Department of Gastroenterology, Changhai Hospital, Shanghai, China Department of Physical Medicine and RehabilitationQilu Hospital, Shandong University, Jinan, China Department of Entomology, College of Plant Protection, Nanjing Agricultural University, Nanjing 210095, Jiangsu, China; The Key Laboratory of Monitoring and Management of Plant Diseases and Insects, Ministry of Agriculture, Nanjing 210095, Jiangsu, China.; Department of Entomology, College of Plant Protection, Nanjing Agricultural University, Nanjing 210095, Jiangsu, China; The Key Laboratory of Monitoring and Management of Plant Diseases and Insects, Ministry of Agriculture, Nanjing 210095, Jiangsu, China. 1 Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 45108, USA,; 3 Department of Biological Chemistry, University of Michigan, Ann Arbor, MI 45108, USA Department of Systems Biology for Medicine, Shanghai Medical College, and Institutes of Biomedical Sciences, Fudan University, 138 Yixueyuan Road, Shanghai 200032, China College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, China State Key Laboratory of Materials-Oriented Chemical Engineering, College of Food Science and Light Industry, Nanjing University of Technology, Nanjing 210009, China. zy886024@163.com Massachusetts Institute of Technology 3 Department of Nuclear Science and Engineering, , Cambridge, Massachusetts 02139, USA Department of Pharmacology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, 100191, China. National Institute on Drug Dependence, Peking University, No. 38, Xueyuan Road, Haidian District, Beijing, 100191, China. School of Chemical Sciences, University of Chinese Academy of Sciences, Beijing 100049, China NMPA Key Laboratory for Research and Evaluation of Narcotic and Psychotropic Drugs Xuzhou Medical University Xuzhou China; Jiangsu Province Key Laboratory of Anesthesiology Xuzhou Medical University Xuzhou China Key Laboratory of Animal Genetics and Breeding and Molecular Design of Jiangsu Province, College of Animal Science and Technology, Yangzhou University, Yangzhou, China Jiangsu Key Laboratory of Neuropsychiatric Diseases and College of Pharmaceutical Sciences Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases Soochow University Suzhou Jiangsu China Key Laboratory of Horticultural Plant Biology College of Horticulture and Forestry Sciences Huazhong Agricultural University Wuhan China College of Materials Science and Engineering, Wuhan Textile University, Wuhan 430200, China; Hubei Key Laboratory of Advanced Textile Materials & Application, Wuhan 430200, China State Key Laboratory of Kidney Diseases, Department of Nephrology, Chinese PLA Institute of Nephrology, National Clinical Research Center for Kidney Disease, Chinese PLA General Hospital Anhui Institute of Optics and Fine Mechanics Department of Materials Science and Engineering National University of Singapore Singapore 117575 Singapore Department of Medicine Zhejiang Academy of Traditional Chinese Medicine Hangzhou Zhejiang China Mechanical and Electronical Engineering College, Gansu Agricultural University, Lanzhou 730070, China Laboratory of Medical Genetics Harbin Medical University People's Republic of China Department of Thoracic Surgery and State Key Laboratory of Genetic Engineering, Fudan University Shanghai Cancer Center, Shanghai, China; Institute of Thoracic Oncology, Fudan University, Shanghai, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China Research Center of Neuroscience, Jiaxing University Medical College, Jiaxing, 314001 Zhejiang, China; Department of Physiology, Shihezi University Medical College, Shihezi, 832002 Xinjiang, China; Department of Anesthesiology, Affiliated Hospital of Jining Medical University, Guhuai Road, Jining, 272000 Shandong, China State Key Laboratory of Rare Earth Resource Utilization; Changchun Institute of Applied Chemistry; Chinese Academy of Sciences; Changchun; P. R. China Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan, USA Shanghai Key Laboratory of Chemical Biology, School of Pharmacy East China University of Science and Technology Shanghai China Department of Chemistry KTH—Royal Institute of Technology Teknikringen 36 10044 Stockholm Sweden Key Laboratory of Behavioral and Mental Health of Gansu Province, School of Psychology, Northwest Normal University, Lanzhou, P. R. China Institute of Medicinal Plant Development; Chinese Academy of Medicinal Sciences; Peking Union Medical College; Beijing; China School of Biology and Food Engineering; Changshu Institute of Technology; Changshu; PR China Authors' Affiliations: Departments of 1Thoracic Surgery and 2Pathology, Fudan University Shanghai Cancer Center; 3Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China; and 4Vanderbilt-Ingram Cancer Center, Nashville, Tennessee; Authors' Affiliations: Departments of 1Thoracic Surgery and 2Pathology, Fudan University Shanghai Cancer Center; 3Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China; and 4Vanderbilt-Ingram Cancer Center, Nashville, Tennessee Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, United States Department of Oncology The Second Hospital of Dalian Medical University Dalian Liaoning P. R. China Shanxi Key Laboratory of Bone and Soft Tissue Injury Repair, Department of Orthopedics, the Second Hospital of Shanxi Medical University, Taiyuan, China State Key Laboratory of Coal Combustion School of Energy and Power Engineering Huazhong University of Science and Technology 1037 Luoyu Road Wuhan 430074 China Center for Computational Medicine and Bioinformatics, University of Michigan, 100 Washtenaw Ave, Ann Arbor, MI 48109, USA Department of Clinical Laboratory Center, Fuwai Hospital & Cardiovascular Institute, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. The State Key Laboratory of Polymer Materials Engineering, Polymer Research Institute of Sichuan University, Chengdu 610065, China Laboratory for Molecular Photonics, Departments of Biology and Chemistry, University of Miami, 1301 Memorial Drive, Coral Gables, Florida 33146-0431, United States Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Cancer Epidemiology, Peking University Cancer Hospital and Institute, Beijing, China School of Chemistry & Chemical Engineering, Henan University of Technology, Zhengzhou 450001, P. R. China Department of Oncology the Second Xiang‐Ya Hospital Central South University Changsha Hunan China Department of Otorhinolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, PR China Jiangsu Key Laboratory of Crop Genetics and Physiology/Co-Innovation Center for Modern Production Technology of Grain Crops/Research Institute of Rice Industry Engineering Technology, Yangzhou University, Yangzhou 225009, P.R. China. Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China. State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, P. R. China Laboratory of Regenerative Biomaterials Department of Biomedical Engineering Health Science Center Shenzhen University Shenzhen Guangdong Province 518037 P. R. China Department of Chemistry and Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Fudan University, Shanghai, 200433, P. R. China, and Department of Chemistry and Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Fudan University, Han Dan Road, 220, Shanghai, 200433, P. R. China University of Wisconsin-Madison, School of Pharmacy, Madison, Wisconsin 57305-2222, USA. Department of Radiation Oncology, Rutgers–Cancer Institute of New Jersey, Rutgers-Robert Wood Johnson Medical School, 195 Little Albany St., New Brunswick, NJ 08903, USA Jiangsu Key Laboratory of Translational Research and Therapy for Neuro‐Psycho‐Diseases and College of Pharmaceutical Sciences Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases Soochow University Suzhou Jiangsu P. R. China Shunde Hospital, Southern Medical University (The First People’s Hospital of Shunde Foshan) , Foshan 528308, China Third Military Medical University The Southwest Hospital, , Chongqing, Gaotanyan Road, Shapingba District, 400038, P.R . China Shenyang Fourth People’s Hospital of China Medical University, Shenyang 110000, China Peking Union Medical College Hospital, Department of Ophthalmology, Chinese Academy of Medical Sciences, Beijing, China; Key Lab of Ocular Fundus Diseases, Chinese Academy of Medical Sciences, Beijing, China Weifang Teda Environmental Protection Equipment Co., Ltd., Weifang 262100, China Innovative Drug Research and Bioinformatics Group; School of Pharmaceutical Sciences and Collaborative Innovation Center for Brain Science; Chongqing University; Chongqing 401331; China College of Mechanical and Electrical Engineering, Qingdao University, 308 Ningxia Road, Qingdao 266071, China State Key Laboratory of Biobased Material and Green Papermaking, Key Laboratory of Pulp and Paper Science & Technology of Ministry of Education/Shandong Province, Key Laboratory of Pulp, Paper, Printing & Packaging of China National Light Industry, Key Laboratory of Green Printing & Packaging Materials and Technology in Universities of Shandong Province, School of Light Industry Science and Engineering, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250353, China Department of Anesthesiology, Xiangyang No. 1 People's Hospital, Hubei University of Medicine, Xiangyang, Hubei 441000, P.R. China Cambridge-Suda Genomic Research Center, Soochow University, Suzhou, China Li Ka Shing Institute of Health Sciences and Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong Key Laboratory of Microbiology, School of Life Science, Heilongjiang University, Harbin 150080, China Department of Chemistry Zhejiang University Hangzhou 310027 China Department of Speech-Language-Hearing Sciences and Masonic Institute for the Developing Brain, University of Minnesota, Minneapolis, Minnesota, USA. State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Fujian 361102, China. Li Ka Shing Institute of Health Sciences, Departments of Medicine and Therapeutics, Chemical Pathology, and Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Hong Kong SAR, China State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences Nanjing University Nanjing Jiangsu 210023 P. R. China Department of Applied Physics The Hong Kong Polytechnic University Kowloon, Hong Kong P. R. China; The Hong Kong Polytechnic University Shenzhen Research Institute Shenzhen 518057 P. R. China Cancer Center, Cancer Research Institute, Foshan Hospital, Sun Yat-sen University, Foshan, Guangdong 528000, China State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian National Laboratory for Clean Energy, Zhongshan Road 457, Dalian 116023, China Traditional Chinese Medical hospital of Zhuji, Zhejiang province, China Centre for Inflammation Research, Centre for Inflammation Research at the University of Edinburgh, Queen’s Medical Research Institute, Edinburgh BioQuarter, Edinburgh, Scotland Department of Computer Science, New Mexico State University, Las Cruces, New Mexico, USA College of Chemistry; Beijing Normal University; Beijing 100875; China Department of Pharmacology, School of Basic Medical Sciences, Anhui Medical University, Hefei 230032, China Department of Neurology Affiliated Drum Tower Hospital of Nanjing University Medical School Nanjing Jiangsu China Zhejiang Lab, Hangzhou, China 1 Department of Computational Medicine and Bioinformatics and 2Department of Biological Chemistry, University of Michigan, 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218, USA; 1 Department of Computational Medicine and Bioinformatics and 2Department of Biological Chemistry, University of Michigan, 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218, USA Department of Orthodontics, School of Stomatology; China Medical University; Shenyang 110001 China Authors' Affiliations: 1Cell Engineering Research Center and Department of Cell Biology, Fourth Military Medical University, Xi'an; Key Laboratory of Behavioral and Mental Health of Gansu Province, School of Psychology, Northwest Normal University, Lanzhou, People’s Republic of China Cancer Research Institute, Medical School, University of South China, Hengyang, Hunan 421001, P.R. China Department of Immunology, School of Basic Medical Sciences, and Key Laboratory of Medical Immunology of Ministry of Health, Peking University Health Science Center, Beijing 100191, China State Key Laboratory of Crop Stress Biology for Arid Areas, College of Plant Protection, Northwest A&F University, Xianyang, Shaanxi 712100, China State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health Xiamen Xiamen University Xiamen 361102 China School of Mechanics and Civil Engineering, China University of Mining and Technology, Beijing Campus, Beijing 100083, China School of Pharmaceutical Sciences, Jilin University, Changchun 130021, PR China. The Pennsylvania State University 2 Materials Research Institute, , University Park, Pennsylvania 16802, USA; Harbin Engineering University 3 Key Laboratory of Superlight Materials and Surface Technology, Ministry of Education, College of Materials Science and Chemical Engineering, , Harbin 150001, China School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, People’s Republic of China Department of Clinical Research, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China Electron Microscopy for Materials Science, University of Antwerp, Antwerp 2000, Belgium Ultrasound, Shengjing Hospital of China Medical University, Shenyang, China Department of Pharmacy, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, China; State Key Laboratory of Genetic Engineering Department of Biochemistry School of Life Sciences Fudan University Shanghai China ‡Institute of Molecular Biology, University Hospital Essen, University Duisburg-Essen, D-45147 Essen, Germany School of Mechanical and Electrical Engineering, Heilongjiang University, Harbin 150080, China. zhangyang@hlju.edu.cn Department of Chemical Engineering Shanghai Jiao Tong University Shanghai 200240 China Neuro-Oncology Branch, Center for Cancer Research, National Cancer Institute, MD 20892, U.S.A. Department of Gastroenterology, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou, Henan 450007, P.R. China Supercomputing Center of Lanzhou University Lanzhou China Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, Texas Chinese Academy of Sciences, Hefei Institutes of Physical Science, Anhui Institute of Optics and Fin Department of Pathology University of Maryland School of Medicine Baltimore MD USA Center for Smart Materials and Devices, State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Luoshi Road 122, Wuhan, 430070, P. R. China Center for Computational Medicine and Bioinformatics, University of Michigan, 100 Washtenaw Avenue, Ann Arbor, Michigan 48109-2218, United States Department of Health Statistics, Fourth Military Medical University, Xi’an, China Department of Respiratory Medicine The First Affiliated Hospital of Soochow University Suzhou China; Institute of Respiratory Diseases Soochow University Suzhou China Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery Systems; School of Pharmaceutical Sciences; Peking University; Beijing 100191; China Shandong Provincial Key Laboratory of Animal Resistant, School of Life Sciences, Shandong Normal University, Jinan, China State Key Laboratory of Silkworm Genome Biology Key Laboratory for Sericulture Functional Genomics and Biotechnology of the Agricultural Ministry Southwest University Chongqing China Jiangsu Key Laboratory of Biological Cancer Therapy, Xuzhou Medical College, Xuzhou, P.R. China. Neurosurgical Department, Peking University First Hospital, No. 8 Xishiku Street, Xicheng District, Beijing 100034, China College of Optical Science and Engineering, Zhejiang University, Hangzhou 310027, China Department of Psychology, Soochow University, Suzhou, P. R. China; yzhangpsy@suda.edu.cn School of Pharmacy, Shenyang Medical College, Shenyang 110034, China Northeast Normal University, Changchun 130024, P. R. China University of California Department of Physics and Astronomy, , Irvine, California 92697, USA Department of Physics and Nanjing National Laboratory of Microstructures, Nanjing University, Nanjing 210093, PR China Department of Radiotherapy, Tumor Hospital of First People's Hospital of Foshan, Foshan, Guangdong 528041, P.R. China Key Laboratory of Animal Genetics and Breeding and Molecular Design of Jiangsu Province, Yangzhou University, Yangzhou, People's Republic of China Department of Nuclear, Plasma and Radiological Engineering, University of Illinois at Urbana−Champaign, Urbana, Illinois 61801, United States; Department of Materials Science and Engineering, University of Illinois at Urbana−Champaign, Urbana, Illinois 61801, United States Department of Neurosurgery The Affiliated Guangdong Second Provincial General Hospital of Jinan University Guangzhou City China The State Key Laboratory of Polymer Materials Engineering, Sichuan Provincial Engineering Laboratory of Plastic/Rubber Complex Processing Technology, Polymer Research Institute of Sichuan University, Chengdu 610065, China 1 Bioinformatics Centre and Key Laboratory for NeuroInfomation of the Education Ministry of China, School of Life Science, University of Electronic Science and Technology of China, Chengdu 610054 and 2 College of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150086, China Department of Radiation Oncology Rutgers‐Cancer Institute of New Jersey New Brunswick New Jersey USA Department of Mechanical and Materials Engineering Nebraska Center for Materials and Nanoscience University of Nebraska-Lincoln Lincoln USA Xidian University State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Science, Shanghai 200050, China Hefei National Laboratory for Physical Sciences at the Microscale and Synergetic Innovation Center of Quantum Information and Quantum Physics, University of Science and Technology of China, Hefei, Anhui 230026, China Research Center for Analytical Sciences, Northeastern University, Box 332, Shenyang 110819, China Division of Gastrointestinal and Hepatic Pathology, Joint Pathology Center , Silver Spring, Maryland , USA Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China; China National Clinical Research Center for Neurological Diseases, Beijing, China Bayer AG Wuppertal Germany Rui Wang, Haichuan Hu, Yunjian Pan, Yuan Li, Ting Ye, Chenguang Li, Xiaoyang Luo, Lei Wang, Hang Li, Yang Zhang, Yongming Lu, Qiong Lu, Jie Xu, Lei Shen, Yihua Sun, and Haiquan Chen, Fudan University Shanghai Cancer Center; Rui Wang, Haichuan Hu, Yunjian Pan, Yuan Li, Ting Ye, Chenguang Li, Xiaoyang Luo, Lei Wang, Hang Li, Yang Zhang, Yongming Lu, Qiong Lu, Jie Xu, Lei Shen, Yihua Sun, and Haiquan Chen, Shanghai Medical College, Fudan University; David Garfield, ProMed Cancer Centers; Fei Li and Hongbin... The State Key Laboratory of Physical Chemistry of Solid Surfaces, iChEM, Fujian Provincial Key Laboratory of Theoretical and Computational Chemistry and College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, Fujian 361005, China Department of Orthopaedics, The Second Affiliated Hospital of Harbin Medical University, Harbin, P. R. China Plant Protection Research Institute, Guangdong Academy of Agricultural Science Guangzhou China State Key Laboratory of High-Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 585 Heshuo Road, Shanghai 201899, China; Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, Beijing 100049, China Medical Research Center, Taizhou Hospital of Zhejiang Province, Wenzhou Medical University, Linhai, Zhejiang, China b Department of Cell Engineering , Institute of Orthopedics, Tianjin Hospital , Tianjin , 300211 , P. R. China Key Laboratory of Green Process and Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China. yangzhang@home.ipe.ac.cn Centre for Behavioural Ecology and Evolution (CBEE) and Hubei Collaborative Innovation Center for Green Transformation of Bio‐Resources College of Life Sciences, Hubei University Wuhan China Key Laboratory of Carcinogenesis and Translational Research, Ministry of Education/Beijing, Department of Cancer Epidemiology, Peking University Cancer Hospital and Institute, Beijing, China. Department of Orthodontics, School of Stomatology, China Medical University, Shenyang, China Department of Oral & Maxillofacial Surgery, The Key Laboratory of Stomatology, College and Hospital of Stomatology, Hebei Medical University, Shijiazhuang, Hebei, China Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde), Foshan, China Department of Pharmacy, Tongji Hospital of Tongji Medical College, Huazhong University of Science & Technology, 13 Hangkong Road, Wuhan 430030, Hubei, China Department of Computational Medicine and Bioinformatics , University of Michigan, Ann Arbor, MI 48109; Department of Biological Chemistry , University of Michigan, Ann Arbor, MI 48109, USA State Key Laboratory of Coal Combustion, School of Energy and Power Engineering Huazhong University of Science and Technology 430074 Wuhan PR China 1Biology DepartmentSchool of Life Sciences2State Key Laboratory of BiocontrolInstitute of Aquatic Economic Animals, School of Life Sciences, Sun Yat-Sen University, Guangzhou 510275, People's Republic of China3The Key Laboratory of Applied Marine Biology of Guangdong Province and Chinese Academy of SciencesSouth China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, People's Republic of China Hangzhou Traditional Chinese Medicine Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China Faculty of Education, Henan Normal University, Xinxiang, China College of Life Science, South China Normal University, Guangzhou 510631, China; Department of Bioscience, Aarhus University, Aarhus C8000, Denmark Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China Department of Computational Medicine and Bioinformatics Department of Biological Chemistry, The University of Michigan, Ann Arbor, MI 2 Center for Informational Biology, University of Electronic Science and Technology of China , Chengdu, China Shandong University Institute of Ecology and Biodiversity, School of Life Sciences, , 72 Binhai Road, Qingdao 266237 , China; Shandong University Shandong Provincial Engineering and Technology Research Center for Vegetation Ecology, , 72 Binhai Road, Qingdao 266237 , China; Shandong University Qingdao Forest Ecology Research Station of National Forestry and Grassland Administration, , 72 Binhai Road, Qingdao 266237 , China Dalian Ecological and Environmental Affairs Service Center, Dalian 116000, China. Research Center for Analytical Sciences; Department of Chemistry; College of Sciences; Northeastern University; Shenyang 110819 Department of Thoracic Surgery, the Northern Hospital, Shenyang, Liaoning, China.; Department of Thoracic Surgery, Shengjing Hospital, China Medical University, 36 Sanhao Street, Heping District, Shenyang, Liaoning 110004, China.; Research Center for Medical Genomics and MOH Key Laboratory of Cell Biology, School of Medicine, China Medical University, Shenyang, Liaoning, China. Department of Ophthalmology,PUMC Hospital,CAMS and PUMC,Beijing 100730,China. a School of Food Science and Technology, Research Center of Natural Products, Jiangnan University , Wuxi, China Beijing Tongren Hospital, Capital Medical University, Beijing, China Department of Bioengineering, Beckman Institute of Advanced Science and Technology, UIUC, Urbana, IL 61801, USA, Department of Endocrinology, the First Affiliated Hospital of Xi'an Jiaotong University School of Medicine, Xi'an, China Department of Experimental Pharmacology and Toxicology, School of Pharmaceutical Science, Jilin University, Changchun, Jilin 130021, P.R. China Key Laboratory of Saline-Alkali Vegetation Ecology Restoration, Ministry of Education, Northeast Forestry University, Harbin 150040, China; College of Life Science, Northeast Forestry University, Harbin 150040, China 10Biomedical Engineering, The University of Texas at El Paso, El Paso, Texas. Department of Biomaterials, Radboud Institute for Molecular Life SciencesRadboudumc Nijmegen The Netherlands Department of Orthopedics, Xinqiao Hospital, The Third Military Medical University, Chongqing 400037, P.R. China Department of Oncology, The Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116027, P.R. China Department of Neurosurgery, The Third People’s Hospital of Chengdu, Chengdu, Sichuan 610031, China Department of Radiation Oncology Rutgers‐Cancer Institute of New Jersey Robert Wood Johnson Medical School New Brunswick NJ USA; Department of Radiological Sciences University of California Irvine CA USA State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing, People's Republic of China. Department of Epidemiology and Medical Statistics, School of Public Health, and Institute of Medical Systems Biology, Guangdong Medical College, Dongguan, Guangdong, China. School of Energy and Environmental Engineering, Beijing Key Laboratory of Resource-oriented Treatment of Industrial Pollutants, University of Science and Technology Beijing, Beijing 100083, China; China-ASEAN Environmental Cooperation Center, Ministry of Environmental Protection, Beijing, China Fujian Provincial Key Laboratory of Theoretical and Computational Chemistry, The State Key Laboratory of Physical Chemistry of Solid Surfaces, and College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, Fujian 361005, China Clinical Pharmacometrics, Bayer AG Wuppertal Germany Department of Pharmacology, Hebei Medical University, Shijiazhuang 050017, China Department of Biochemistry and Molecular Biology, University of Georgia , Athens , GA 30602 , USA Massachusetts Institute of Technology Department of Earth, Atmospheric and Planetary Sciences, Earth Resources Laboratory, , Cambridge, Massachusetts 02139 Department of Biochemistry & Molecular Biology, State Key Laboratory of Common Mechanism Research for Major Diseases, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College , 5 Dong Dan San Tiao, Beijing 100005 , China Institutes of Biomedical Sciences, Department of Chemistry and Zhongshan Hospital, Fudan University, 130 DongAn Road, Shanghai 200032, China Department of Hepatobiliary Surgery, Binzhou Medical University Hospital, Binzhou, Shandong 256603, P.R. China Key Laboratory of Biomedical Polymers of Ministry of Education; Department of Chemistry; Wuhan University; Wuhan 430072; P. R. China State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China. Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, 10085, China School of Public Health, Jilin University, Changchun 130021, Jilin, P. R. China Department of Ophthalmology, Huashan Hospital, Fudan University, Shanghai 200040, P.R. China 2Department of Biosystems Science and Engineering, ETH Zürich, Basel, Switzerland. 1Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Cancer Epidemiology, Peking University Cancer Hospital and Institute, Beijing, People's Republic of China. Department of Cardiology, Shunde Hospital, Southern Medical University, Foshan, China Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China. Institute of Vascular Medicine and Li Ka Shing Institute of Health Sciences Chinese University of Hong Kong Hong Kong China Endocrinology Department Peking University First Hospital Beijing China Department of Dermatology, The Central Hospital of Enshi Tujia and Miao Autonomous Prefecture, Enshi, PR China 1College of Veterinary Medicine, Southwest University, Rongchang District, Chongqing 402460, China. Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China Department of Urology, the Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China *Department of Molecular Biology, University of Duisburg-Essen, Essen; and Department of OB/GYN, Peking University Third Hospital, Beijing 100191, P.R. China Department of Pediatrics, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, China Department of Speech-Language-Hearing Sciences and Center for Neurobehavioral Development, University of Minnesota 4 , Minneapolis, Minnesota 55455, USA zhanglinjunb@sina.com , absenteedec@163.com , charlesyuli@sina.com , shuhua@bnu.edu.cn , zhang470@umn.edu Key Laboratory for Biobased Materials and Energy of Ministry of Education Guangdong Laboratory for Lingnan Modern Agriculture College of Materials and Energy South China Agricultural University Guangzhou 510642 China Department of Clinical Research, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangzhou, People's Republic of China Department of Neurology, The Second Affiliated Hospital University of South China Hengyang Hunan China e Tianjin Orthopedic Hospital, Tianjin 300211, P.R. China Research and Development, Pharmaceuticals Bayer AG Wuppertal/Leverkusen Germany State key laboratory of optoelectronic materials and technology, Guangdong Provincial Key Laboratory of low carbon chemistry and process energy conservation, School of Materials Science and Engineering, Sun Yat-sen University, Guangzhou 510275, People’s Republic of China State Key Laboratory of Petroleum Pollution Control China University of Petroleum (East China) Qingdao 266580 P. R. China College of Environmental and Chemical Engineering; Zhaoqing University; Zhaoqing; China Key Laboratory of Maricultural Organism Disease Control, Yellow Sea Fisheries Research Institute, Chinese Academic of Fishery Sciences, Qingdao 266071, China; College of Fisheries and Life Science, Shanghai Ocean University, Shanghai 201306, China Department of Neurosurgery, The First Affiliated Hospital of Jilin University, Changchun, China. State Key Laboratory of Rare Earth Resource Utilization; Changchun Institute of Applied Chemistry; Chinese Academy of Sciences; Changchun 130022; People's Republic of China Department of Vascular Surgery, General Surgery Center, The First Hospital of Jilin University, Changchun, China. Central Hospital Affiliated to Shenyang Medical College, Shenyang, China Fuzhou Neuro-Psychiatric Hospital Affiliated to Fujian Medical University, Fuzhou, Fujian 350008, China Hefei National Laboratory for Physical Sciences at the Microscale and Synergetic Innovation Center of Quantum Information and Quantum Physics University of Science and Technology of China Hefei Anhui 230026 China ENT Institute and Otorhinolaryngology Department Affiliated Eye and ENT Hospital State Key Laboratory of Medical Neurobiology Fudan University Shanghai 200031 China; Key Laboratory of Hearing Medicine of NHFPC Shanghai 200031 China Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College Department of Orthopedics, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China Department of Polymer Materials, Zhejiang Sci-Tech University, Hangzhou, Zhejiang 310018, China; National Engineering Laboratory for Textile Fiber Materials and Processing Technology (Zhejiang), Hangzhou, Zhejiang 310018, China; Key Laboratory of Advanced Textile Materials and Manufacturing Technology (ATMT), Ministry of Education, Hangzhou, Zhejiang 310018, China; Institute of Smart Fiber Materials, Zhejiang Sci-Tech University, Hangzhou, Zhejiang 310018, China Department of Biotechnology Dalian Medical University Dalian 116044 China Laboratory Animal Center Wenzhou Medical University Zhejiang People's Republic of China Key Laboratory of Animal Genetics and Breeding and Molecular Design of Jiangsu Province, Yangzhou University, Yangzhou, Jiangsu, P. R. China The MOH Key Laboratory of Geriatrics, Beijing Hospital, National Center of Gerontology, Beijing 100730, P.R. China From the Shenzhen Research Institute, School of Biomedical Sciences, Institute of Vascular Medicine and Li Ka Shing Institute of Health Sciences (W.H., Y.Z., L.W., C.W.L., J.X., J.-Y.L., L.G., X.Y., X.Y.T., Y.H), the School of Life Science (Z.-Y.C.), Department of Medicine and Therapeutics, the Prince of Wales Hospital, Hong Kong; and Institute of Diabetes and Obesity (R.C.W.M), Chinese University of Hong Kong, Hong Kong SAR, China. Department of Biomedical Engineering, College of Biomedical Engineering, Taiyuan University of Technology, Taiyuan, P.R. China Department of Orthopedic and Microsurgery, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China. Institute for Biosensing, and College of Chemistry and Chemical Engineering; Qingdao University; Qingdao 266071; China; School of Pharmacy Biomass and Bioresource Utilization Laboratory, College of Engineering, China Agricultural University, Beijing 100083, P.R. China Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400044, China Department of Bone Surgery, Yangzhou Hongquan Hospital, Yangzhou, Jiangsu, China (mainland) Forestry College of Guizhou University, Guizhou University, Guiyang, China; Research Center of Biodiversity and Nature Conservation, Guizhou University, Guiyang, China State Key Laboratory of Polymer Materials Engineering, Polymer Research Institute of Sichuan University, Chengdu 610065, China Department of Computational Medicine and Bioinformatics , MI 48109, USA; Department of Biological Chemistry, University of Michigan , Ann Arbor, MI 48109, USA School of Chemistry & Chemical Engineering, South China University of Technology, Guangzhou 510640, China. Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Research & Development Center for Natural Products, School of Pharmacy, Yunnan University, Kunming 650500, China Institut Européen des Membranes, IEM, UMR 5635, Université Montpellier, ENSCM, CNRS, Montpellier 34000, France; Institute of Microscale Optoelectronics, Shenzhen University, Shenzhen, Guangdong 518060, China Center of Excellence in Bioinformatics, University at Buffalo, 901 Washington Street, Buffalo, NY 14203 First Clinical Medical School, Shandong University of Traditional Chinese Medicine, Jinan, Shandong 250000, China Department of Orthopedics, Xi Jing Hospital, The Fourth Military Medical University, Xi’an 710032, China Hunan Institute of Advanced Sensing and Information Technology, Xiangtan University, Xiangtan 411105, Hunan, China Institute of Animal Husbandry, Xinjiang Academy of Animal Husbandry, Urumqi, China Department of Anesthesiology The Affiliated Huaian No.1 People’s Hospital of Nanjing Medical University Huai’an Jiangsu China School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China. zhangyang19880702@126.com Department of Otorhinolaryngology Head and Neck Surgery,Children Hospital Affiliated to Zhejiang University of Medicine,Hangzhou,310051,China. National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, Wuhan 430070, China Department of Computational Medicine and Bioinformatics; Department of Biological Chemistry , University of Michigan, Ann Arbor, MI 48109, USA Center for High Pressure Science (CHiPS), State Key Laboratory of Metastable Materials Science and Technology, Yanshan University, Qinhuangdao 066004, People’s Republic of China Department of Oncology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China Key Laboratory for Ultrafine Materials of Ministry of Education, Shanghai Key Laboratory of Advanced Polymeric Materials, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, P.R. China State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine; School of Public Health; Xiamen University; Xiamen 361102; China Center for Immunology and Microbial Disease, MC‐151 Albany Medical College 47 New Scotland Avenue Albany NY USA Department of Cell Biology, National Translational Science Center for Molecular Medicine, Fourth Military Medical University, Xi'an, P.R. China Department of Nursing, Central Hospital of Heilongjiang Province Prison, No. 85, Qi Zheng Street, Nangang District, Harbin, Heilongjiang Province 150805, P.R. China Division of Orthopaedic Surgery, Department of Orthopaedics, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China. nfgjzy@126.com. Hepatobiliary and Enteric Surgery Center Xiangya Hospital, Central South University Changsha Hunan People's Republic of China Department of Neurosurgery, The First Hospital of Jilin University Changchun 130021, P. R. China. College of Veterinary Medicine Jilin University Changchun 130062 China Department of Cardiology, Shunde Hospital, Southern Medical University, Guangdong, China Institute of Modern Optics & Tianjin Key Laboratory of Micro-Scale Optical Information Science and Technology, Nankai University, Tianjin300071, P. R. China Department of Neurosurgery/China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China Tianjin Institute of Orthopedics in Traditional Chinese and Western Medicine Tianjin China Department of Anesthesiology Huai'an First People's Hospital Nanjing Medical University 6 Beijing Road West Huai'an Jiangsu 223300 China a Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital Affiliated with Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China State Key Laboratory of Severe Weather/Laboratory of Lightning Physics and Protection Engineering, Chinese Academy of Meteorological Sciences, China John Innes Centre, Norwich NR4 7UH, United Kingdom University of Strasbourg, CNRS, ISIS UMR 7006, 8 allée Gaspard Monge, 67000 Strasbourg, France Department of Urology, Huadong Hospital, Fudan University, Shanghai 200040, P.R. China Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China College of Chemistry and Chemical Engineering, Hunan University, Changsha, P.R. China School of Energy Materials and Chemical Engineering, Hefei University, Hefei 230000, China 1Cell Engineering Research Center and Department of Cell Biology, State Key Laboratory of Cancer Biology, Fourth Military Medical University, Xian, PR China. Electron Microscopy for Materials Research (EMAT), University of Antwerp, Groenenborgerlaan 171, 2020 Antwerp, Belgium Department of Computational Medicine and Bioinformatics, University of Michigan State Key Laboratory of Petroleum Pollution Control, China University of Petroleum (East China), 66 West Changjiang Road, Qingdao 266580, PR China Key Laboratory of Molecular Biophysics of Ministry of Education, School of Life Science and Technology, Huazhong University of Science and Technology, 1037 Luo Yu Road, Wuhan, Hubei, China, National Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, 189 Guo Shou Jing Road, Shanghai 201203, China, and Institute of Functional Genomics, CNRS UMR5203, INSERM U661, University of... Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Cancer Epidemiology, Peking University Cancer Hospital & Institute, Beijing, China Department of Gastrointestinal Surgery First Hospital of Jilin University Changchun China Department of Medicinal Chemistry Anhui University of Chinese Medicine Hefei China State Key Laboratory of Antitoxic Drugs & Toxicology, Beijing Institute of Pharmacology & Toxicology, Beijing 100850, People’s Republic of China Key Laboratory of Animal Genetics & Breeding and Molecular Design of Jiangsu Province, Yangzhou University, Yangzhou, 225009, China Department of Bioengineering University of Illinois at Urbana‐Champaign Urbana IL USA Department of Histology and Embryology Chongqing Medical University Chongqing People's Republic of China; Laboratory of Stem Cells and Tissue Engineering Chongqing Medical University Chongqing People's Republic of China Shanghai Electrochemical Energy Devices Research Center; School of Chemistry and Chemical Engineering; State Key Laboratory of Metal Matrix Composites; Shanghai Jiao Tong University; Shanghai 200240 Beijing National Laboratory for Molecular Sciences; National Centre for Mass Spectrometry in Beijing; CAS Key Laboratory of Analytical Chemistry for Living Biosystems; Institute of Chemistry; Chinese Academy of Sciences Department of Pathology, Johns Hopkins School of Medicine, Baltimore, MD g Tianjin Orthopedic Hospital, Tianjin 300211, P. R. China 1 Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan 48109, USA; 5 Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan 48109, USA College of Food Science and Engineering, Tianjin University of Science & Technology Tianjin China Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Cancer Epidemiology Peking University Cancer Hospital & Institute Beijing China; PYLOTUM Key Joint Laboratory for Upper GI Cancer, Technische Universität München/Peking University Cancer Hospital & Institute Munich Germany; PYLOTUM Key Joint Laboratory for Upper GI Cancer, Technische Universität München/Peking University Cancer Hospital & Institute Beijing China Material Science Center, Institute of Semiconductors, Chinese Academy of Sciences, P.O. Box 912, Beijing, 100083, People’s Republic of China Department of Neurosurgery, Jining No. 1 People’s Hospital, Jining, Shandong, P.R. China Family Planning Research Institute, Center for Reproductive Medicine, Tongji Medical College, Huazhong University of Science and Technology Wuhan China Department of Hematology, Tianjin Medical University General Hospital, Tianjin, People’s Republic of China Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China National Center for Electron Microscopy in Beijing Key Laboratory of Advanced Materials (MOE) Beijing 100084 China; State Key Laboratory of New Ceramics and Fine Processing School of Materials Science and Engineering Tsinghua University Beijing 100084 China Tufts Univ. Prenatal Diagnosis Center, People's Hospital of Peking University, Beijing 100044, P.R. China Department of Histology and Embryology, Chongqing Medical University, Chongqing, China; Laboratory of Stem Cells and Tissue Engineering, Chongqing Medical University, Chongqing, China Research Center of National Health Ministry on Transplantation Medicine Engineering and Technology The 3rd Xiangya Hospital of Central South University Changsha China Division of Genetics, Department of Medicine, Brigham and Women’s Hospital, Boston, MA; Aging Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA Department of Neurology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China - chenweian2006@126.com. Department of Anesthesiology, Xiangyang No. 1 People’s Hospital, Hubei University of Medicine, Hubei, P.R. China WuXi AppTec, 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131, P. R. China Department of Hematology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China. National Engineering Laboratory for Textile Fiber Materials and Processing Technology (Zhejiang), Hangzhou, Zhejiang 310018, China Instrumental Analysis Center of Xi'an Jiaotong University Xi'an Jiaotong University Xi'an 710049 China Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, National Center for Nanoscience and Technology (NCNST), Beijing 100083, China Graduate Department of Zhejiang Chinese Medicine University , Hangzhou , Zhejiang , China; Department of Infectious Diseases, Affiliated Jinhua Hospital, Zhejiang University School of Medicine , Jinhua , China Department of Neurosurgery China National Clinical Research Center for Neurological Diseases Beijing Tiantan Hospital Capital Medical University Beijing 100050 China Department of Toxicology, Public Health School, Harbin Medical University, Harbin, P.R. China, Laboratory of Regenerative Biomaterials, Department of Biomedical Engineering, Health Science Center, Shenzhen University, Shenzhen 518037, P.R. China Key Laboratory for Ultrafine Materials of Ministry of Education Shanghai Engineering Research Center of Hierarchical Nanomaterials School of Materials Science and Engineering East China University of Science and Technology 130 Meilong Road Shanghai 200237 P. R. China College of Chemistry and Chemical Engineering; Central South University; Changsha; China State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University , Xiamen 361102, China State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical Sciences Peking University Xue Yuan Road No. 38 Beijing 100191 China Department of Molecular Biology, University of Duisburg–Essen, Essen, Germany. Department of Anesthesiology, Liaocheng People’s Hospital , No. 67 of Dongchang West Road , Liaocheng , 252000, Shandong , China Division of Hepatobiliary and Pancreas Surgery Department of General Surgery The First Affiliated Hospital of Nanchang University (The First Clinical Medical College of Nanchang University) Nanchang City Jiangxi Province China Department of Anesthesiology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China Department of Chemistry; KTH-Royal Institute of Technology; Stockholm; Sweden Department of Orthopedics; Spinal Pain Research Institute; Shanghai Tenth People's Hospital; Tongji University School of Medicine; Shanghai 200072 Jiangsu Institute of Hematology, The First Affiliated Hospital, Collaborative Innovation Center of Hematology, Soochow University, Key Laboratory of Thrombosis and Hemostasis, Ministry of Health, Suzhou 215006, China; HwaMei Hospital, University of Chinese Academy of Sciences; Ningbo Institute of Life and Health Industry, University of Chinese Academy of Sciences; Key Laboratory of Diagnosis and Treatment of Digestive System Tumors of Zhejiang Province; Ningbo Clinical Research Center for Digestive System Tumors, Ningbo, Zhejiang, P. R. China School of Agricultural Engineering, Jiangsu University, Zhenjiang 212013, China; School of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, China Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China Department of Orthopedics, Xinqiao Hospital Third Military Medical University, Chongqing, People's Republic of China School of Biology and Food Engineering Changshu Institute of Technology Changshu 215500 China Department of Spine Surgery, the Fourth People's Hospital of Guiyang City, Guiyang Guizhou, 550002, P.R.China. Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, China Zhongnan Hospital Institute of Hepatobiliary Diseases Transplant Center Hubei Key Laboratory of Medical Technology on Transplantation Wuhan University Wuhan Hubei; The 3rd Xiangya Hospital of Central South University Research Center of National Health Ministry on Transplantation Medicine Engineering and Technology Changsha China WuXi AppTec (Shanghai) Co., Ltd., Shanghai, China Department of General Surgery, Tai Zhou Municipal Hospital of Zhe Jiang, Jiaojiang 318099, Zhe Jiang, P. R. China School of Life Sciences (S.Z., Y.Z., W.C., Y.W., L.Z., W.Z.), Sun Yat-sen University, Guangzhou 510275, People's Republic of China Departments of Neurosurgery and Medical Equipment, Second Hospital, Hebei Medical University, Shijiazhuang City, Hebei, China College of Basic Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510006, P.R. China Department of Thyroid and Breast Surgery, Liaocheng People's Hospital, Liaocheng, Shandong 252000, P.R. China State Key Laboratory of Metastable Materials Science and Technology, Yanshan University, Qinhuangdao 066004, China Department of Pediatrics, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China Department of Pharmaceutical Science, School of Pharmacy, The Second Military Medical University, Shanghai 200433, China.; Department of Scientific Research, TongRen Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200050, China. Institutes of Biomedical Sciences and Department of Chemistry, Fudan University, Shanghai 200032, China 2University of Birmingham National Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences , Beijing 100190, China Functional Materials Research Laboratory; School of Materials Science & Engineering; Tongji University; Shanghai 201804; China Department of Pediatric The Second Affiliated Hospital of Xi'an Jiaotong University Xi'an China State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, Hubei, China State Key Laboratory of Toxicology & Medical Countermeasures, Beijing Institute of Pharmacology & Toxicology, Beijing 100850, People’s Republic of China Department of Urology, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China. State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China; Graduate School of the Chinese Academy of Sciences, Beijing 100049, P. R. China Authors' Affiliations: Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), 1Department of Cancer Epidemiology; 2Department of Pathology, Peking University Cancer Hospital & Institute, Beijing, China; and 3Technical University, Munich, Germany 1Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Beijing, China.; 2Department of Cancer Epidemiology, Peking University Cancer Hospital & Institute, Beijing, China. Department of Materials Science and Engineering, National University of Singapore, 9 Engineering Drive 1, Singapore 117575 Beijing Key Laboratory of Bioprocess, National Energy R&D Center for Biorefinery Beijing University of Chemical Technology Beijing People's Republic of China College of Electromechanical Engineering, Qingdao University of Science & Technology, Qingdao 266000, China; Collaborative Innovation Center for Intelligent Green Manufacturing Technology and Equipment of Shandong Province, Qingdao 266000, China Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, China; West China School of Medicine, West China Hospital, Sichuan University, Chengdu, China Heilongjiang Provincial Transportation Investment Group, Harbin 150036, China School of infection and Immunity, College of Medical and Dental Sciences, University of Birmingham, B15 2TT, United Kingdom; University of Florida, Gainesville, FL, USA Department of Cardiology, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, People's Republic of China Istituto Italiano di Tecnologia, Via Morego 30, 16163 Genova, Italy, and CNR-Istituto di Crystallografia (IC), Via Amendola 122/O, I-70126 Bari, Italy Computational Biology Department, School of Computer Science, Carnegie Mellon University , Pittsburgh, PA 15213, USA Center for High Pressure Science (CHiPS), State Key Laboratory of Metastable Materials Science and Technology, Yanshan University , Qinhuangdao 066004, China; Key Laboratory for Microstructural Material Physics of Hebei Province, School of Science, Yanshan University , Qinhuangdao 066004, China Department of Biochemistry and Molecular Biology,Indiana University School of Medicine,Indianapolis,IN Department of Soil, Water, and Environmental Science, University of Arizona, Tucson, AZ 85721 Department of Breast and Thyroid Surgery, Liaocheng People’s Hospital, Liaocheng, Shandong, P.R. China Department of Anesthesiology, Tianjin 4th Center Hospital, Tianjin, China Department of Radiation Oncology, Zhongshan Hospital, Fudan University, Shanghai, China Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, China; Department of Systems Biology for Medicine, Shanghai Medical College, Fudan University, Shanghai 200032, China School of Pharmaceutical Sciences, Jilin University, Changchun 130022. Department of Experimental Pharmacology and Toxicology, School of Pharmacy, Jilin University, Changchun, Jilin Province 130021, China Northwestern Polytechnical University, China National Key Laboratory for Germplasm Innovation & Utilization of Horticultural Crops, College of Horticulture and Forestry Science Huazhong Agricultural University Wuhan 430070 China; Hubei Key Laboratory of Germplasm Innovation and Utilization of Fruit Trees Institute of Fruit and Tea, Hubei Academy of Agricultural Sciences Wuhan 430064 China Cancer Control Research Program, British Columbia Cancer Research Centre, British Columbia Cancer Agency Vancouver BC Canada; School of Population and Public Health, University of British Columbia Vancouver BC Canada Department of Orthopedics, the Seventh Medical Center of Chinese PLA General Hospital, Beijing, 100700, China; College of Enology, Northwest A&F University, Yangling 712100, Shaanxi, People’s Republic of China Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai, China Department of Orthodontics, School and Hospital of Stomatology, China Medical University, Liaoning Provincial Key Laboratory of Oral Diseases, Shenyang, Liaoning 110002, P.R. China Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China;; Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Shanghai, China Hefei National Research Center for Physical Sciences at the Microscale and CAS Center for Excellence in Quantum Information and Quantum Physics University of Science and Technology of China Hefei Anhui 230026 China; School of Physics and Department of Chemical Physics University of Science and Technology of China Hefei Anhui 230026 China; Hefei National Laboratory, University of Science and Technology of China Hefei 230088 China National University of Defense Technology Department of Sociology, and Population Studies Center, University of Michigan, Ann Arbor, MI, USA Guangzhou Zhongda Medical Equipment Company, Guangzhou, China Department of Laboratory Medicine Hebei Yanda Lu Daopei Hospital Langfang China State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Materials Science and Engineering Donghua University Shanghai 201620 China Chinese Education Ministry Key Laboratory of Resource Chemistry, Shanghai Key Laboratory of Rare Earth Functional Materials, Shanghai Normal University, Shanghai 200234, P. R. China Key Laboratory of Green Chemistry Technology Ministry of Education College of Chemistry Sichuan University 610064 Chengdu P. R. China College of Stomatology Chongqing Medical University Chongqing China; Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences Chongqing China Department of Anorectal Surgery, Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Nanjing Department of Urology The second hospital of Tianjin Medical University Tianjin China; Tianjin Institute of Urology Tianjin China Department of Radiation Oncology The Second Affiliated Hospital of Xi'an Jiaotong University Xi'an ShaanXi China John Innes Centre Norwich Research Park Colney Norwich NR4 7UA UK Department of Gastroenterology Tangdu Hospital the Fourth Military Medical University Xi'an China Department of Chemistry, Lehigh University, Bethlehem, Pennsylvania 18105 Department of Oncology, Jilin Province Cancer Hospital, Jilin 130012, China Shenzhen Research Institute of Hunan University Nanshan District Shenzhen 518000 China; State Key Laboratory of Chemo/Biosensing and Chemometrics College of Chemistry and Chemical Engineering Hunan University Changsha 410082 China Department of Pharmacology and Toxicology School of Medicine Virginia Commonwealth University Richmond VA USA Smart Hybrid Materials (SHMs) Lab, Department of Chemical Sciences and Engineering, Advanced Membranes and Porous Materials Center King Abdullah University of Science and Technology (KAUST) Thuwal 23955-6900 Kingdom of Saudi Arabia Jiangsu Key Laboratory of Environmentally Friendly Polymeric Materials, School of Materials Science and Engineering, Jiangsu Collaborative Innovation Center of Photovoltaic Science and Engineering, Changzhou University, Changzhou 213164, Jiangsu, P. R. China Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853 Department of Vascular Surgery, The First Hospital of Jilin University, Changchun, Jilin, China Laboratory of Regenerative Biomaterials, Department of Biomedical Engineering, Health Science Center, Shenzhen University, Shenzhen 518037, P. R. China Pediatric Gastroenterology Division, Department of Pediatrics, School of Medicine, Oregon Health and Science University, Portland, Oregon Department of Experimental Pharmacology and Toxicology; School of Pharmacy; Jilin University; Changchun; China College of Water Sciences Beijing Normal University Beijing China Department of Surgical Oncology, Tangshan People's Hospital, Tangshan, China. McGill University - Montréal Neurological Institute, Montréal, QC, Canada Jiangsu Key Laboratory of Therapeutic Material of Chinese Medicine, Department of Biopharmaceutics and Food Science, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210023, P.R. China State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, Center for Molecular Imaging and Translational Medicine, School of Public Health Xiamen University Xiamen China; Amoy Hopeful Biotechnology Co., Ltd. Xiamen China Tianjin Hospital of Integrated Traditional Chinese and Western Medicine, Tianjin, China Shi-Changxu Innovation Center for Advanced Materials, Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110016, China; School of Materials Science and Engineering, University of Science and Technology of China, Shenyang 110016, China University of Maryland Medical System 22 S. Greene St., Baltimore 21201 MD Department of Thoracic Surgery and State Key Laboratory of Genetic Engineering Fudan University Shanghai Cancer Center Shanghai China; Institute of Thoracic Oncology Fudan University Shanghai China; Department of Oncology Shanghai Medical College Fudan University Shanghai China Department of Materials Science and Engineering, National University of Singapore, 9 Engineering Drive 1, Singapore 117575, Singapore Department of Orthodontics, School of Stomatology, China Medical University, Shenyang, Liaoning, China. State Key Laboratory of Agro-Biotechnology and Laboratoire International Associe Franco-Chinois de Bio-Mineralisation et Nano-Structures, College of Biological Sciences, China Agricultural University, Beijing 100193, China Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, Tianjin, People’s Republic of China; TEDA Institute of Biological Sciences and Biotechnology, Nankai University, Tianjin, People’s Republic of China Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, China From the Department of Pharmacology & Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University. Department of Gastrointestinal Surgery, The First Hospital of Jilin University, Changchun, Jilin, China Medical Research Council Centre for Immune Regulation, School of Immunity and Infection 1 ; and 2; Centre for Systems Biology, School of Biosciences; University of Birmingham, Birmingham B15 2TT, England, UK 1 ; and 2 Henan Key Laboratory of Crystalline Molecular Functional Materials, Green Catalysis Center and College of Chemistry, Zhengzhou University, Zhengzhou 450001, China Department of Anesthesiology, Liaocheng People’s Hospital, Liaocheng, Shandong, China Gansu Analyze and Research Center, Lanzhou 730000, China. Department of Orthopaedics, The Second Hospital of Shanxi Medical University; Shanxi Key Laboratory of Bone and Soft Tissue Injury Repair, Taiyuan, China Department of Applied Physics; Xi'an Jiaotong University; Xi'an 710049; China Institute of Semiconductors Chinese Academy of Sciences Beijing 100083 P.R. China Department of Mechanical & Electrical Engineering, Xiamen University, Xiamen 361005, China; Shenzhen Research Institute of Xiamen University, Shenzhen 518057, China Department of Anesthesiology, Binzhou City People’s Hospital, Binzhou, Shandong, China (mainland) Department of Materials Science and Engineering, National University of Singapore, 117575 Singapore. School of Stomatology, Health Science Center, Shenzhen University, Shenzhen, P.R. China. State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, People’s Republic of China; University of the Chinese Academy of Sciences, Beijing 100049, People’s Republic of China Department of Computational Medicine and Bioinformatics , University of Michigan, Ann Arbor, MI 48109, USA Department of Psychology, College of Education Northeast Normal University Changchun 130024 China School of Horticulture, Anhui Agricultural University, Hefei, 230036, China Department of Thoracic Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang, China Statistical Consultant, University of Florida College of Medicine School of Medicine and Pharmacy, Key Laboratory of Marine Drugs, Ministry of Education Ocean University of China Qingdao China Laboratory of Computational Genomics, Donald Danforth Plant Science Center, 975 North Warson Road, St. Louis, MO 63132; and Faculty of Chemistry, Warsaw University, Pasteura 1, 02-093 Warsaw, Poland 3Department of Biochemistry and Molecular BiologyIndiana University School of Medicine, Indianapolis, USA Department of Computational Medicine and Bioinformatics, University of Michigan, Washtenaw Avenue, Ann Arbor, MI, USA State Key Laboratory of Palaeobiology and Stratigraphy, Nanjing Institute of Geology and Palaeontology, CAS, Nanjing 210008, China; School of Earth Sciences and Resources, China University of Geosciences (Beijing), Beijing 100083, China Jiangsu Key Laboratory of Neuropsychiatric Diseases and College of Pharmaceutical Sciences, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Soochow University, 199 Ren'ai Road, Suzhou, Jiangsu 215123, China College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China; School of Pharmaceutical Sciences, Chongqing University, Chongqing, China School of Biology and Food Engineering Changshu Institute of Technology Changshu China Pen-Tung Sah Institute of Micro-Nano Science and Technology, Xiamen University, Xiamen 361005, China Orthopaedic Department Tongren Hospital affiliated to Shanghai Jiaotong University China State Key Laboratory of Biocontrol, Key Laboratory of Gene Engineering of the Ministry of Education and Guangdong Key Laboratory of Plant Resources, School of Life Sciences, Sun Yat-sen University, 510275 Guangzhou, People’s Republic of China First Affiliated Hospital, Heilongjiang University of Chinese Medicine Department of Thoracic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China From the Department of Laboratory Medicine (Y.Z., W.F.) and Department of Neurosurgery (Y.C.), Southwest Hospital, Third Military Medical University, Chongqing, China; Department of Physiology and Pharmacology, Loma Linda University, CA (Y.Z., Y.C., J.W., A.M., P.Y., J.T., J.H.Z.); and Department of Neurosurgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, 215006, China (J.W.). Innovative Drug Research and Bioinformatics Group, School of Pharmaceutical Sciences, Chongqing University, Chongqing 401331, China; 1 Department of Computer Science, New Mexico State University, Las Cruces, NM 88003, USA, 2Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA, 3Molecular and Cellular Biology Graduate Program, University of Washington, Seattle, WA 98195, USA and 4German Cancer Research Center (DKFZ)–Center for Molecular Biology Heidelberg (ZMBH) Alliance, Im Neuenheimer Feld 282, D-69120 Heidelberg, Germany Department of Computational Medicine and Bioinformatics, University of Michigan, 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218, USA State Key Laboratory of Coordination Chemistry; Nanjing National Laboratory of Microstructures and School of Chemistry and Chemical Engineering; Nanjing University; Nanjing, P. R. China Hebei Yanda Lu Daopei Hospital, Langfang, P.R. China Department of Radiotherapy, Shuguang Hospital Affiliated to Shanghai University of Chinese Traditional Medicine, Zhang Heng Road, Pudong New Area, Shanghai 201203, China The Academy of Military Medical Science, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China. Caltech Optical Imaging Laboratory Andrew and Peggy Cherng Department of Medical Engineering Department of Electrical Engineering California Institute of Technology Pasadena CA 91125 USA State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Science, Beijing 100190, China Ministry of Education Key Laboratory for Nonequilibrium Synthesis and Modulation of Condensed Matter, School of Physics, Xi’an Jiaotong University, Xi’an 710049, China Institute of Stem Cell Research and Regenerative Medicine, Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, People’s Republic of China University of Nebraska-Lincoln, Lincoln, NE School of Materials Science and Engineering, State key Laboratory of Optoelectronic Materials and Technology Sun Yat‐Sen University Guangzhou 510275 P. R. China School of Dentistry Medical School Shenzhen University Shenzhen 518060 China University of Strasbourg CNRS ISIS UMR 7006 8 allée Gaspard Monge 67000 Strasbourg France Uppsala University, Department of Immunology, Genetics and Pathology, Dag Hammarskjölds väg 20, 752 85 Uppsala, Sweden Department of Hematology, The Second Affiliated Hospital, Xi'an Jiaotong University Medical School, Xi'an 710004, Shanxi Province, China. Institutes of Biomedical Sciences Fudan University, Shanghai, China Key Laboratory of Bio‐resource and Eco‐environment of Ministry of Education, College of Life Sciences Sichuan University Chengdu China School of Microelectronics, Xi’an Jiaotong University, Xi’an710049, China Department of Chemistry; Zhejiang University; Hangzhou 310027; P. R. China School of Pharmacy Lanzhou University Lanzhou China Department of Medicine & Therapeutics, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China College of Veterinary Medicine, Yangzhou University, Yangzhou, People’s Republic of China; State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing, People’s Republic of China Key Laboratory of Tropical Marine Bio‐resources and Ecology South China Sea Institute of Oceanology Chinese Academy of Sciences Guangzhou 510301 China Peking University Fifth School of Clinical Medicine, Beijing, China; The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Beijing Hospital, National Center of Gerontology, National Health Commission, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China School of Economics and Management, Beijing Forestry University, Beijing 100083, China College of Mechanical and Electrical Engineering, Beijing University of Chemical Technology, Beijing 100029, China State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, CAS , Beijing 100190, China School of Pharmaceutical Science and Technology Tianjin University Tianjin China Shenzhen Research Institute of Hunan University Nanshan District Shenzhen 518000 State Key Laboratory of Chemo/Biosensing and Chemometrics College of Chemistry and Chemical Engineering Hunan University Changsha 410082 China State Key Laboratory of Genetic Engineering Department of Biochemistry School of Life Sciences Fudan University Shanghai P. R. China Biostatistics Atara Biotherapeutics Inc Thousand Oaks California Key Laboratory for Liquid-Solid Structural Evolution and Processing of Materials (Ministry of Education) School of Materials Science and Engineering Shandong University Ji'nan 250061 Shandong P. R. China Tianjin First Center Hospital, NO.24 Fukang Road, Nankai District, Tianjin 300192, China Department of Neurology, Drum Tower Hospital, Medical School of Nanjing University, Nanjing, PR China; The State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, PR China; Jiangsu Key Laboratory for Molecular Medicine, Nanjing University Medical School, Nanjing, PR China; Jiangsu Province Stroke Center for Diagnosis and Therapy, Nanjing, PR China; Nanjing Neuropsychiatry Clinic Medical Center, Nanjing, PR China Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University and Beijing Ophthalmology & Visual Sciences Key Laboratory, National Engineering Research Center for Ophthalmology, Beijing 100005, China MOE Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology Department of Chemistry Tsinghua University Beijing 100084 China Department of Speech-Language-Hearing Sciences and Center for Neurobehavioral Development, University of Minnesota , Minneapolis, Minnesota 55455, USA zhang470@umn.edu The Genetic Engineering International Cooperation Base of Chinese Ministry of Science and Technology Key Laboratory of Molecular Biophysics of Chinese Ministry of Education College of Life Science and Technology Huazhong University of Science and Technology (HUST) Wuhan China Esperion Therapeutics, Inc. Ann Arbor MI Istituto Italiano di Tecnologia, Via Morego 30, 16163 Genova, Italy University of Wisconsin-Madison, School of Pharmacy, Madison, WI 53705-2222, USA. Department of Anesthesiology, Huai'an First People's Hospital, Nanjing Medical University, Huai'an, Jiangsu 223300, P.R. China Institute of Nephrology Zhong Da Hospital Southeast University School of Medicine Nanjing City Jiangsu Province China School of Materials Science and Engineering, Key Laboratory for Ultrafine Materials of Ministry of Education, East China University of Science and Technology, Shanghai 200237, China Supercomputer Center, Lanzhou University, Lanzhou 730000, China Beijing Great‐Agri Institute of Pesticide Technology Beijing China College of Information Science and Technology, Beijing University of Chemical Technology, Beijing, China National Center for Electron Microscopy in Beijing, School of Materials Science and Engineering, The State Key Laboratory of New Ceramics and Fine Processing, Key Laboratory of Advanced Materials (MOE), Tsinghua University, Beijing 100084, P.R. China; State Key Laboratory of Low Dimensional Quantum Physics and Department of Physics, Tsinghua University, Beijing 100084, P.R. China; Ji Hua Laboratory, Foshan 528299, P.R. China Department of Occupational and Environmental Medicine, School of Public Health, Wuhan University of Science and Technology, Wuhan 430060, China Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing Tongren Hospital, Capital Medical University, Beijing, China Yang Zhang, Xiao-Yu Hu, Sen Zhong, Guo Chen, Yan-Yan Wang, Department of Infectious Diseases, Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610072, Sichuan Province, China. Department of Urology, The Second People’s Hospital of Neijiang, Neijiang, Sichuan Province 641000, China Department of Material Chemistry, Graduate School of Engineering, Kyoto University, Katsura Nishikyo-ku, Kyoto 615-8510, Japan Department of Vascular Surgery, Beijing Chaoyang Hosptial, Capital Medical University, Beijing 100020, China. Parasites Laboratory, Veterinary College, Xinjiang Agricultural University, Nongda East 311, Urumqi, Xinjiang, 830052, P. R. China. College of Chemistry and Life Science, Shenyang Normal University, Shenyang 110034, China. zywjb1975@hotmail.com Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853, United States Research Institute of Neural Tissue Engineering, Mudanjiang College of Medicine, Mudanjiang, P.R. China Department of Pharmacy, Shanghai Tenth People’s Hospital of Tongji University, Shanghai, China; Department of Computational Medicine and Bioinformatics; Department of Biological Chemistry, University of Michigan , Ann Arbor, MI 48109, USA Division of Pathology and Laboratory Medicine, Hebei Yanda Lu Daopei Hospital, Langfang, China; Department of Nuclear Science and Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, Department of Chemistry, National Taiwan University, Taipei, 106, Taiwan, and Neutron Scattering Science Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831 HKU-Pasteur Research Centre, Hong Kong SAR, People's Republic of China; Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, People's Republic of China State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine School of Public Health Xiamen Xiamen University Xiamen 361102 China Laboratory of Medical Genetics Harbin Medical University Harbin China Department of Periodical Press, West China Hospital, Sichuan University, Chengdu, China Chengdu Medical College Second Affiliated Hospital, Chengdu, China School of Public Health, Harbin Medical University, Harbin 150086,China. zhangyang1962@sina.com Key Laboratory of Horticultural Plant Biology (MOE) College of Horticulture and Forestry Sciences Huazhong Agricultural University Wuhan 430070 China Department of Anesthesiology, The First Affiliated Hospital of Nanchang University, Nanchang 330006, P.R. China Electron Microscopy for Materials Science (EMAT), University of Antwerp, Groenenborgerlaan 171, 2020 Antwerp, Belgium College of Materials Science and Engineering, Sichuan University, Chengdu, 610064, China Department of Laboratory Medicine; Southwest Hospital; Third Military Medical University; Chongqing 400038; China Department of Neurology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325027, China Tufts University Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Provincial Key Laboratory of Applied Marine Biology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, China; South China Sea Bio-Resource Exploitation and Utilization Collaborative Innovation Center, Guangzhou, China; Innovation Academy of South China Sea Ecology and Environmental Engineering, Chinese Academy of Sciences, Guangzhou, China Department of Urology, Jiangsu Provincial Hospital of Traditional Chinese Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210029, China. Key Laboratory for Evaluation and Utilization of Poultry Genetic Resources of Ministry of Agriculture and Rural Affairs, Yangzhou University, Yangzhou 225009, China From the Departments of Anesthesiology and Basic Sciences, Loma Linda University School of Medicine, CA (Y.H., L.X., B.L., Z-N.G., Q.H., Z.G., Junjia Tang, Y.C., Y.Z., Jiping Tang, J.H.Z.); Department of Neurosurgery, Tong-ji Hospital, Wuhan, PR China (Y.H.); Department of Neurosurgery, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, PR China (L.X., J.T.); Department of Neurosurgery, Jinan General Military Hospital, Jinan, PR China (B.L.); and Department of... Innovative Institute of Chinese Medicine and Pharmacy, Chengdu University of Traditional Chinese Medicine , Chengdu 611137, China CAS Key Laboratory of Tropical Marine Bio-Resources and Ecology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China Department of Computational Medicine & Bioinformatics, University of Michigan, Ann Arbor, MI, USA. Department of Biological Chemistry, University of Michigan, Ann Arbor, MI, USA. State Key Laboratory of Oncology in South China, Guangzhou, Guangdong, 510060, P. R. China. Department of Gynaecology , Xuzhou Medical University Affiliated Hospital of Lianyungang Lianyungang , Jiangsu , China Institute for Integrative Nanosciences, IFW Dresden, Helmholtzstraße 20, 01069 Dresden, Germany Department of General Surgery, The First Affiliated Hospital of University of Science and Technology of China, Hefei 230031, China National Energy R&D Center for Biorefinery, Beijing Key Laboratory of Bioprocess, Beijing University of Chemical Technology, Beijing, 15th Beisanhuan East Road, Beijing, 100029, PR China Department of Anesthesiology, The First Affiliated Hospital of Nanchang University, Nanchang City, Jiangxi Province, 330006, China National Translational Science Center for Molecular Medicine,; Department of Cell Biology, Fourth Military Medical University, Xi’an, China; School of Dentistry, Health Science Center, Shenzhen University, Shenzhen, China. Department of Pharmacological and Pharmaceutical SciencesCollege of Pharmacy, University of HoustonHoustonTX Department of Dermatology, The Second Affiliated Hospital, School of Medicine, Xi’an Jiaotong University, Xi’an, 710004 Shaanxi, China;; Department of Dermatology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599; Department of Chemical Engineering, Tsinghua University, Beijing 100084, People's Republic of China School of Environmental Science and Engineering, State Key Laboratory of Separation Membranes and Membrane Processes, Tiangong University, Tianjin 300387, China Nankai University Institute of Arid Ecology and Environment, Xinjiang University, Urumqi 830046, China; Key Laboratory of Oasis Ecology, Education Ministry, Urumqi 830046, China; Institute of Resources and Environment Sciences, Xinjiang University, Urumqi 8300462, China Institute of Vascular Medicine, Chinese University of Hong Kong, Hong Kong SAR, China.; Li Ka Shing Institute of Health Sciences, Chinese University of Hong Kong, Hong Kong SAR, China. Department of Gastrointestinal Surgery, The First Hospital, Jilin University, Changchun, 130021 Jilin Province, China Department of Neurology Affiliated Drum Tower Hospital of Nanjing University Medical School Nanjing China; Stroke Center for Diagnosis and Therapy in Jiangsu province Nanjing China Department of Civil and Environmental Engineering, Arizona State University, Tempe, Arizona 85287-5306 Department of Pediatrics, Guizhou Provincial People’s Hospital, Guiyang, Guizhou, China Spine Division, Department of Orthopedics, Central Hospital Affiliated to Shenyang Medical College, Shenyang, Liaoning 110024, P.R. China Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA; Department of Biological Chemistry, University of Michigan, Ann Arbor, MI 48109, USA Department of Pharmacy, Beijing Friendship Hospital, Capital Medical University, Beijing, China; Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery Systems, State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, China Department of Rehabilitation Medicine, Anhui Provincial Hospital, Hefei, Anhui, China Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Cancer Epidemiology, Peking University Cancer Hospital and Institute, Beijing, China Department of Medicine and Therapeutics and Li Ka Shing Institute of Health Sciences, the Chinese University of Hong Kong, Hong Kong, China Peking University Fifth School of Clinical Medicine, Beijing 100730, P.R. China Affiliated Psychological Hospital of Anhui Medical University Hefei Anhui China; Anhui Clinical Center for Mental and Psychological Diseases Hefei Fourth People's Hospital Hefei Anhui China; Anhui Mental Health Center Hefei Anhui China Department of Radiology, Fuyang People’s Hospital, Fuyang 236000, Anhui Province, China Center for X-Mechanics and Institute of Applied Mechanics, Zhejiang University, Hangzhou 310012, PR China Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education Beijing Advanced Innovation Center for Biomedical Engineering School of Biological Science and Medical Engineering Beihang University Beijing 100191 China Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Provincial Center for Research & Development of Natural Products, School of Chemical Science and Technology, Yunnan University, Kunming 650091, China Nursing Teaching and Research Institute, Medical College of Guangxi University of Science and Technology, Liuzhou, Guangxi Province, China School of Materials Science and Engineering, Shaanxi University of Technology, Hanzhong 723001, China Starkey Hearing Technologies, Eden Prairie, Minnesota. College of Life Science and Health, Wuhan University of Science and Technology, Wuhan 430065, China Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine Ministry of Education/Institute of Medicinal Plant Development Chinese Academy of Medical Sciences Peking Union Medical College Beijing China The Kidney Transplantation and Hemopurification Center of PLA, 181 Hospital of PLA, Guilin, Guangxi Province, P.R. China. Key Laboratory for Polymeric Composite and Functional Materials of Ministry of Education Key Laboratory of High Performance Polymer-based Composites of Guangdong Province GBRCE for Functional Molecular Engineering School of Chemistry Sun Yat-sen University Guangzhou 510006 China Anhui Province Key Laboratory of Advanced Catalytic Materials and Reaction Engineering, School of Chemistry and Chemical Engineering Hefei University of Technology Hefei China The Pennsylvania State University 2 Materials Research Institute, , University Park, Pennsylvania 16802, USA; Harbin Engineering University 4 Metal Research Institute for Marine Engineering, College of Materials Science and Chemical Engineering, , Harbin 150001, China Department of Biology University of Utah Salt Lake City UT 84112 USA a Department of Marine, Earth and Atmospheric Sciences , North Carolina State University , Raleigh , NC , USA Center for Nanomedicine, Department of Anesthesiology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA Shanghai Center for Plant Stress Biology and National Key Laboratory of Plant Molecular Genetics CAS Center for Excellence in Molecular Plant Sciences Chinese Academy of Sciences Shanghai 200032 China ENT Institute and Otorhinolaryngology Department of Affiliated Eye and ENT Hospital State Key Laboratory of Medical Neurobiology Fudan University Shanghai 200031 China; Key Laboratory of Hearing Medicine of NHFPC Shanghai 200031 China Department of Endocrinology Affiliated Hospital of Weifang Medical University Weifang China National Integrative Medicine Clinical Base for Infectious Diseases/Department of Infectious Diseases, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610072, Sichuan Province, China; Clinical Medical College, Chengdu University of Traditional Chinese Medicine, Chengdu 610072, Sichuan Province, China National Translational Science Center for Molecular Medicine, Xi’an, China; Department of Cell Biology, Fourth Military Medical University, Xi’an, China Department of Marine, Earth, and Atmospheric Sciences, North Carolina State University, Raleigh, NC 27695; Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education) Department of Cancer Epidemiology Peking University Cancer Hospital & Institute Beijing China Department of Thoracic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China Department of Pharmacology, Key Laboratory of Cardiovascular Medicine Research, State‐Province Key Laboratories of Biomedicine‐Pharmaceutics of China, Ministry of Education College of Pharmacy, Harbin Medical University Harbin China Innovative Institute of Chinese Medicine and Pharmacy, Chengdu University of Traditional Chinese Medicine, China Department of Radiology and Department of Dermatology and Dermatopathology at Columbia and Cornell Universities, 416 E 55th St., New York, NY 10022. Jiangsu Key Laboratory for Animal Genetic, Breeding, and Molecular Design, Yangzhou University, Yangzhou 225009, China China-ASEAN Environmental Cooperation Center, 100035 Beijing, China; South China Institute of Collaborative Innovation, Dongguan523808, China; Guangdong Dongguan Quality Supervision Testing Center, Dongguan523808, China Department of Entomology, University of California, Riverside, CA 92521;; Key Laboratory of Tropical Marine Bio-Resources and Ecology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China; State Key Laboratory of Applied Organic Chemistry, Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, College of Chemistry and Chemical Engineering, and ‡Ministry of Education Key Laboratory of Cell Activities and Stress Adaptations, School of Life Sciences, Lanzhou University, Lanzhou 730000, P. R. China Department of Orthopaedic Surgery, Division of Orthopaedics Nanfang Hospital, Southern Medical University Guangzhou China; Pediatric Research Center, Department of Pediatrics UTHealth McGovern Medical School Houston TX USA Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan. Department of Experimental Pharmacology and Toxicology, School of Pharmacy, Jilin University, Changchun, China Department of Radiation Oncology, Zhongshan Hospital, Fudan University , Shanghai , China Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Department of Radiation Oncology, The Second Affiliated Hospital of Xian Jiaotong University, Xi’an City, Shanxi Province, 710003, China School of Pharmaceutical Sciences, Chongqing University, Chongqing 401331, China Department of the Gastrointestinal Surgery, The First Hospital of Jilin University, Changchun, Jilin 130021, China The first affiliated hospital of the University of Science and Technology of China, Hefei, 230031, China Department of Clinical Laboratory; Union Hospital; Tongji Medical College; Huazhong University of Science and Technology; Wuhan Hubei China Department of Ophthalmology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China. Department of Sociology and Population Studies, Renmin University of China , Beijing, China Department of Speech-Language Hearing Science, University of Minnesota, Minneapolis, Minnesota; Center for Neurobehavioral Development, University of Minnesota, Minneapolis, Minnesota; Center for Applied and Translational Sensory Science, University of Minnesota, Minneapolis, Minnesota Department of Physical Medicine & Rehabilitation, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China Chinese Badminton Association, Zhejiang Jiaxing Badminton Association, Zhejiang Province, China; Computational Biology Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, PA, USA Department of Biomedical Engineering Northwestern University 2145 Sheridan Road Evanston IL 60208 USA School of Food Science and Technology, Dalian Polytechnic University, No. 1 Qinggongyuan, Ganjingzi District, Dalian 116034, China; Liaoning Key Lab for Aquatic Processing Quality and Safety, No. 1 Qinggongyuan, Ganjingzi District, Dalian 116034, China Department of Breast Surgery, Shengjing Hospital of China Medical University, Sanhao Street No. 36, Heping District, Shenyang, Liaoning 110004, China The Education Ministry Key Laboratory of Resource Chemistry and Shanghai Key Laboratory of Rare Earth Functional Materials, Department of Chemistry, College of Life and Environmental Sciences, Shanghai Normal University, Shanghai, China Center for Immunology and Microbial Disease, MC‐151 Albany Medical College 47 New Scotland Avenue Albany NY 12208‐3479 USA Department of Anesthesiology, Xuzhou Medical University, Xuzhou, Jiangsu 221004, P.R. China Key Laboratory of Breeding Biotechnology and Sustainable Aquaculture, Key Laboratory of Tropical Marine Bio-resources and Ecology and Guangdong Provincial Key Laboratory of Applied Marine Biology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, China Benxi institute for Drug Control, No. 31 Shengli Road, Mingshan District, Benxi 117000, P.R. China West China School of Medicine, West China Hospital, Sichuan University, Chengdu 610041, China; Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu 610041, China China Building Materials Academy The State Key Laboratory of Physical Chemistry of Solid Surfaces, Fujian Provincial Key Laboratory of Theoretical and Computational Chemistry, and College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, Fujian 361005, China Department of Breast Surgery, Xingtai First Hospital, Xingtai, Hebei 054001, P.R. China Key Laboratory for Ultrafine Materials of Ministry of Education School of Materials Science and Engineering East China University of Science and Technology Shanghai 200237 China) E-mails Department of Neurosurgery, Guangdong No. 2 Provincial People's Hospital, Guangzhou, Guangdong 510317, P.R. China Department of Orthopaedic Surgery Nanfang Hospital, Southern Medical University Guangzhou China Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853, and Department of Chemistry, Texas A&M University, College Station, Texas 77842 Department of Speech-Language-Hearing Sciences and Center for Neurobehavioral Development, University of Minnesota 3 , Minnesota 55455, USA pang_wenbin@126.com , xinghb@blcu.edu.cn , zhanglinjunb@sina.com , shuhua@bnu.edu.cn , zhang470@umn.edu School of Materials Science and Engineering Key Laboratory of Advanced Joining Technology Tianjin University Tianjin 300072 China Developmental Therapeutics Branch, Center for Cancer Research National Cancer Institute, National Institutes of Health Bethesda MD USA Hefei National Laboratory for Physical Sciences at the Microscale and ‡CAS Key Laboratory of Soft Matter Chemistry and Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, China Department of Laboratory Diagnostics, The First Affiliated Hospital of University of Science and Technology of China, Hefei, Anhui 230031, P.R. China School of Pharmacy, Anhui Medical University, No. 81 Meishan Road, Shushan District, Hefei 230032, China Beijing Institute of Ophthalmology, Beijing Tongren Eye Center and Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing Tongren Hospital, Capital Medical University, Beijing, China Multifunctional Materials & Composites (MMC) Laboratory, Department of Engineering Science, University of Oxford, Parks Road, Oxford OX1 3PJ, U.K. State Key Laboratory of Crop Stress Biology for Arid Areas, College of Plant Protection Northwest A&F University Yangling 712100 Shaanxi China Department of Hepatology, Zaozhuang Municipal Hospital, Zaozhuang, Shandong, China State Key Laboratory of Photocatalysis on Energy and Environment College of Chemistry Fuzhou University 350116 Fuzhou China Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, USA Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan China Department of Anesthesiology, University of Illinois College of Medicine, Chicago, Illinois;; Department of Anesthesiology, Xuzhou Medical College, Xuzhou, China Department of Neurology Affiliated Drum Tower Hospital of Nanjing University Medical School Nanjing 210008 China Institute of Agricultural Economics and Information Research, Anhui Academy of Agricultural Science, Hefei, Anhui 230031, People’s Republic of China College of Informatics, Huazhong Agricultural University, Wuhan, Hubei, China Henan Institute of Science and Technology, School of Agriculture, Xinxiang 453003, China; The Genetic Engineering International Cooperation Base of Chinese Ministry of Science and Technology, The Key Laboratory of Molecular Biophysics of Chinese Ministry of Education, College of Life Science and Technology, Huazhong University of Science & Technology, Wuhan 430074, China *Department of Anesthesiology, University of Illinois College of Medicine, Chicago, IL 60612; Nursing Teaching and Research Institute, Medical College of Guangxi University of Science and Technology, Liuzhou, Guangxi Province, 545005 Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania, USA Department of Radiological Sciences, University of California, Irvine, CA 92697, USA Department of Pharmacology, State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Medicine Research, Ministry of Education (H.X., M.Z., H.W., J.W., X.H., X.P., D.L., L.Z., Q.H., B.M., X.Z., L.P., Z.L., W.Y., Q.Z., Y.Z., Y.L., Z.P.), Harbin Medical University, P.R. China. Department of General Surgery, Wuhan General Hospital of Guangzhou Military Command, Wuhan 430070, China School of Pharmaceutical Sciences; Chongqing University; Chongqing 401331; China; College of Pharmaceutical Sciences Laboratory of Regeneromics, School of Pharmacy, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, China. Department of Orthopedics The First Affiliated Hospital of Zhengzhou University Zhengzhou China b Department of Arthroscopic Surgery Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China Laboratory of Atmospheric Physico-Chemistry, Anhui Institute of Optics and Fine Mechanics, HFIPS, Chinese Academy of Sciences, Hefei, 230031 Anhui, China Department of Emergency State Key Laboratory of Biotherapy West China Hospital School of Chemical Engineering Sichuan University No. 17 Renmin Nan Road Chengdu 610041 China Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853, USA State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics and Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen 361102, China Center for Molecular Reproductive Medicine Nanjing University Nanjing China Institute of Nephrology, Zhongda Hospital, School of Medicine, Southeast University Department of Gastrocolorectal Surgery, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 45108, USA National Key Laboratory of Crop Genetic Improvement Huazhong Agricultural University Wuhan 430070 China Institute of Modern Optics & Tianjin Key Laboratory of Micro‐Scale Optical Information Science and Technology Nankai University Tianjin 300071 China Department of Computational Medicine and Bioinformatics, University of Michigan , Ann Arbor, MI 48109-2218, USA Department of Rheumatology and Immunology, Shuyang County Hospital of Traditional Chinese Medicine, Suqian, P.R. China Department of Tumor Cell Biology, St. Jude Children’s Research Hospital , Memphis, TN, USA Institute of Clinical Blood Transfusion, Guangzhou Blood Center Guangzhou P.R. China Department of Computational Medicine and Bioinformatics University of Michigan Ann Arbor Michigan USA; Department of Biological Chemistry University of Michigan Ann Arbor Michigan USA; Department of Computer Science School of Computing, National University of Singapore Singapore Singapore; Cancer Science Institute of Singapore, National University of Singapore Singapore Singapore; Department of Biochemistry Yong Loo Lin School of Medicine, National University of Singapore Singapore Singapore Department of Infectious Diseases, First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China. Department of Computational Medicine and Bioinformatics, University of Michigan , Ann Arbor, MI 48109, USA; Department of Biological Chemistry, University of Michigan , Ann Arbor, MI 48109, USA Key Laboratory of Energy Materials Chemistry; Ministry of Education; Institute of Applied Chemistry; Xinjiang University; Urumqi 830046; China Department of Orthopedics, State Key Discipline of Cell Biology, Xijing Hospital, The Fourth Military Medical University Xi'an 710018, Shaanxi, China. Division of Digestive Diseases, Department of Internal Medicine, and Departments of Pharmacology and Molecular Physiology, Rush University Medical Center, Chicago, Illinois 60612; and CAS Key Laboratory of Forest Ecology and Management, Institute of Applied Ecology, Chinese Academy of Sciences , Shenyang 110016, China Beijing Advanced Innovation Center for Soft Matter Science and Engineering Beijing University of Chemical Technology Beijing 100029 P. R. China Institute for Immunology and Immunotherapy, Institute for Biomedical Research, University of Birmingham Medical School, Vincent Drive, B15 2TT, Birmingham, UK. Y.Zhang.10@bham.ac.uk. University of Minnesota Department of Speech-Language-Hearing Sciences and Center for Neurobehavioral Development, , Minneapolis, Minnesota 55455, USA zhang470@umn.edu 5School of Public Health (Shenzhen), Sun Yat-sen University, Guangdong, China Department of Systems Biology for Medicine, Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai, China Department of Radiotherapy, Tumor Hospital of First People’s Hospital of Foshan, Foshan, Guangdong 528041, China Key Laboratory of Tropical Marine Bio-resources and Ecology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, China Department of Thoracic Surgery Fudan University Shanghai Cancer Center Shanghai China; Department of Oncology Shanghai Medical College Fudan University Shanghai China Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China Department of Joint Trauma, General Hospital of Shenzhen University, Shenzhen Guangdong, 518055, P.R.China. Department of Neurology, West China Hospital of Sichuan University, Chengdu, PR China Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, P.R. China Beijing National Laboratory for Molecular Sciences; Beijing 100190; PR China; CAS Key Laboratory of Analytical Chemistry for Living Biosystems; Institute of Chemistry Beijing Key Laboratory of Bioprocess, National Energy R&D Center for Biorefinery, Beijing University of Chemical Technology. 15th, Beisanhuan East Road, Beijing 100029, People’s Republic of China Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology & Visual Sciences Key Lab, Beijing, China State Key Laboratory of Rice Biology and Ministry of Agriculture Key Laboratory of Molecular Biology of Crop Pathogens and Insects, Institute of Biotechnology Zhejiang University Hangzhou 310058 China; Institute of Genetics and Physiology Hebei Academy of Agriculture and Forestry Sciences Shijiazhuang 050051 China Jiangsu Key Laboratory of Environmentally Friendly Polymeric Materials, School of Materials Science and Engineering, Jiangsu Collaborative Innovation Center of Photovoltaic Science and Engineering, Changzhou University, Changzhou 213164, Jiangsu, People’s Republic of China Max Planck Institute for Chemical Physics of Solids, 01187 Dresden, Germany; School of Materials Science and Engineering State key laboratory of optoelectronic materials and technology Guangdong Provincial Key Laboratory of low carbon chemistry and process energy conservation Guangzhou Key Laboratory of Flexible Electronic Materials and Wearable Devices Sun Yat‐sen University Guangzhou 510275 P. R. China Department of Human Anatomy, Henan Key Laboratory of Medical Tissue Regeneration, School of Basic Medical Sciences Xinxiang Medical University Xinxiang China University of Illinois at Urbana-Champaign 3 Department of Nuclear, Plasma, and Radiological Engineering, , Urbana, Illinois 61801, USA First Affiliated Hospital of Xinjiang Medical University, Oncology Center, 137 Liyushan Road, Urumqi 830011, China Institute of Orthopaedics, Xijing Hospital, The Fourth Military Medical University, No. 17 Changle Xi Road, Xi’an, Shaanxi province 710032, P.R. China Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, IL 2; Computational Biology Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, PA 3 Department of Systems Biology for Medicine, Shanghai Medical College, Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, China Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing, China Department of Biopharmacy, School of Pharmacy, Jilin University, Changchun 130021, Jilin Province, China. Department of Orthopaedics, Xinqiao Hospital Army Medical University Chongqing China Department of Endocrinology, Peking University First Hospital, Beijing 100034, China. The Center of Clinical Aviation Medicine, PLA, General Hospital of Air Force, Beijing, 100142, China. Department of Pharmacology and Toxicology Virginia Commonwealth University School of Medicine Richmond VA USA Heilongjiang University of Chinese Medicine, Heilongjiang 150040, China. Department of Thoracic Surgery Fudan University Shanghai Cancer Center Shanghai China; Department of Oncology Shanghai Medical College, Fudan University Shanghai China Department of Cardiology,PUMC Hospital,CAMS and PUMC,Beijing 100730,China. School of Pharmacy, East China University of Science and Technology, Shanghai Key Laboratory of Chemical Biology, Shanghai, China; Department of Chemical Engineering, Process Engineering for Sustainable Systems (ProcESS), KU Leuven, W. de Croylaan 46, B-3001 Leuven, Belgium; Separation and Conversion Technology, Flemish Institute for Technological Research (VITO), Boeretang 200, B-2400 Mol, Belgium Department of Anesthesiology Huai'an First People's Hospital, Nanjing Medical University 6 Beijing Road West, Huai'an Jiangsu 223300 China Department of Pathophysiology, School of Basic Medical Sciences, Shanxi Medical University, Taiyuan, China Electrical Power Research Institute, Jilin Electrical Power Company Limited, Changchun 130021, Jilin, China Institute of Modern Optics, and Tianjin Key Laboratory of Micro-Scale Optical Information Science and Technology, Nankai University, Tianjin 300071, P.R. China Department of Physical Medicine and Rehabilitation, Qilu Hospital of Shandong University, Jinan, China Department of Geriatric Gastroenterology, The First Affiliated Hospital with Nanjing Medical University, Institute of Neuroendocrine Tumor Nanjing Medical University Nanjing China Department of Cadre Ward Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical College Beijing China Department of Neurosurgery, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, P.R. China Department of Ultrasound in Medicine Sixth People's Hospital Affiliated to Shanghai Jiao Tong University Shanghai China School of Engineering, Faculty of Science and Engineering Macquarie University Sydney, NSW 2109 Australia Authors' Affiliations: Departments of 1Head and Neck Surgery, and 2Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas; and 3Department of Otolaryngology-Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, China; Authors' Affiliations: Departments of 1Head and Neck Surgery, and 2Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas; and 3Department of Otolaryngology-Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, China Department of Biochemistry, Duke University Medical Center, Durham, NC, USA. ENT Institute and Otorhinolaryngology Department of Affiliated Eye and ENT Hospital, State Key Laboratory of Medical Neurobiology, Fudan University; Key Laboratory of Hearing Medicine of NHFPC Department of Orthopaedics, Xijing Hospital, the Air Force Medical University, Xi'an City, China Department of Tissue Engineering Research Office, Orthopaedic Research Institute of Tianjin Hospital, Tianjin, China Department of Medicine and Pathology, Cancer Research Institute, Beth Israel Deaconess Cancer Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. Institute of Vascular Medicine, Shenzhen Research Institute, and Li Ka Shing Institute of Health Sciences, Chinese University of Hong Kong, Hong Kong, China Department of Chemistry; Zhejiang University; Hangzhou 310027; China Department of Anesthesiology, Xiangyang NO.1 People’s Hospital, Hubei University of Medicine, Xiangyang, China Clincal College of Acupuncture-Moxibustion and Orthopedic, Anhui University of Chinese Medicine, Hefei, Anhui Province, China Department of Thoracic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China2Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China Department of Cardiology, Shanghai Ninth People’s Hospital, China University of Maryland, Baltimore, MD, USA Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, People's Republic of China Department of Pathology and Laboratory Medicine Division, Hebei Yanda Lu Daopei Hospital, Sanhe, Hebei 065201, P.R. China Department of Nephrology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, P.R. China State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics and Center for Molecular Imaging and Translational Medicine School of Public Health Xiamen University Xiamen 361102 China Key Laboratory of Horticultural Plant Biology (MOE), College of Horticulture and Forestry Sciences Huazhong Agricultural University Wuhan 430070 China Department of Agronomy and Horticulture University of Nebraska‐Lincoln Nebraska USA School of Materials Science and Engineering, State Key Laboratory of Optoelectronic Materials and Technology, Guangdong Provincial Key Laboratory of Low Carbon Chemistry and Process Energy Conservation, Guangzhou Key Laboratory of Flexible Electronic Materials and Wearable Devices, Sun Yat-sen University, Guangzhou 510275, P. R. China Department of Hematology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710004, P.R. China Institute of Theoretical Physics, Shanxi Datong University, Datong 037009, China 1Developmental Therapeutics Branch, Center for Cancer Research, NCI, Bethesda, Maryland. National Center for Electron Microscopy in Beijing, School of Materials Science and Engineering, Key Laboratory of Advanced Materials of Ministry of Education of China, State Key Laboratory of New Ceramics and Fine Processing, Tsinghua University, Beijing 100084, China 2Chemistry and Biomedicine Innovation Center (ChemBIC), Nanjing University, Nanjing, Jiangsu, China.; 3State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, China. School of Basic Medicine, Gannan Medical University, Ganzhou, China School of Mechanics and Safety Engineering, National Center for International Research of Micro-Nano Molding Technology, Zhengzhou University, Zhengzhou 450001, China Dentistry – Regenerative Biomaterials Nijmegen The Netherlands; School of Medicine, Shenzhen University Shenzhen China Department of Oncology, The Second Xiang-Ya Hospital, Central South University, Changsha, PR China; Department of Chemistry, Zhejiang University, Hangzhou 310027, China Tu and Yuen Center for Functional Onco-Imaging, Department of Radiological Sciences, University of California Irvine, Irvine, CA 92697, USA State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing, China; Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China The State Key Laboratory of Physical Chemistry of Solid Surfaces, Fujian Provincial Key Laboratory of Theoretical and Computational Chemistry, and College of Chemistry and Chemical Engineering,, Xiamen University, Xiamen, Fujian 361005, China College of Chemistry and Chemical Engineering, Chongqing University of Science and Technology, Chongqing 401331, China Department of Emergency, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, and School of Chemical Engineering, Sichuan University, Chengdu 610041, China Key Laboratory of Biotechnology of Antibiotics; Ministry of Health; Institute of Medicinal Biotechnology; Chinese Academy of Medical Sciences & Peking Union Medical College; Beijing China Department of Neurosurgery From the Institute of Vascular Medicine, Li Ka Shing Institute of Health Sciences (Y.Z., L.W., J.L., W.S.C., C.W.L., X.Y., Y.H.), School of Biomedical Sciences (J.L., Y.C., X.Y., Y.H.), School of Life Sciences (K.M.K.), Chinese University of Hong Kong, Hong Kong SAR, China; Department of Cardiovascular Sciences, Houston Methodist Research Institute, Houston, TX (X.Y.T., W.T.W.); and Institute of Cardiovascular Sciences, Peking University Health Science Center, Beijing, China (N.W.). Smart Hybrid Materials Laboratory (SHMs), Advanced Membranes and Porous Materials Center, King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Saudi Arabia Cancer Research Institute, Hengyang Medical College, University of South China, 28 Western Changsheng Road, Hengyang, Hunan 421001, P.R. China School of Public Health (Shenzhen), Sun Yat-sen University, Guangdong, China (Y.Z.). Division of Pharmaceutical Sciences and Department of Chemistry, University of Wisconsin, Madison, Wisconsin 53705 Anhui Engineering Laboratory of Functional Membrane Materials and Technology Collaborative Innovation Centre of Chemistry for Energy Materials School of Chemistry and Material Science University of Science and Technology of China Hefei 230026 P. R. China Department of Endocrinology Peking University First Hospital Beijing China Department of Periodical Press and National Clinical Research Center for Geriatrics, West China Hospital Sichuan University Chengdu China; Chinese Evidence‐Based Medicine Center, West China Hospital Sichuan University Chengdu China School of Public Health, Jilin University, Changchun, Jilin 130021, China State Key Laboratory of Genetic Engineering, Department of Biochemistry, School of Life Sciences, Fudan University, Shanghai 200438, China Anesthesiology and Department of Oncology, The Second Hospital of Dalian Medical University , No.467 Zhongshan Road, Shahekou District , Dalian , Liaoning , China Department of Endocrinology, Peking University First Hospital , Beijing 100034 , China Department of Endocrinology, Peking University First Hospital, Beijing, People’s Republic of China Internet Medical Department of Love Life Insurance Company Beijing China Key Laboratory for Green Processing of Chemical Engineering of Xinjiang Bingtuan/School of Chemistry and Chemical Engineering; Shihezi University; People's Republic of China State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences Xiamen University Fujian China Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, Beijing 100083, China Department of Dermatology Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical College, Xuzhou, Jiangsu, China. Engineering Research Center of Electronic Information Materials and Devices (Ministry of Education), Guangxi Key Laboratory of Information Materials, Guangxi Collaborative Innovation Center of Structure and Property for New Energy and Materials, College of Materials Science and Engineering, Guilin University of Electronic Technology, Guilin 541004 Guangxi, China Shenzhen Research Institute, Institute of Vascular Medicine, and Li Ka Shing Institute of Health Sciences Chinese University of Hong Kong Hong Kong SAR China; Division of Genetics, Department of Medicine, Brigham and Women's Hospital Harvard University Boston MA USA Laboratory of Regenerative Biomaterials, Department of Biomedical Engineering, Health Science Center, Shenzhen University, 3688 Nanhai Avenue, Shenzhen 518037, P. R. China; Regenerative Biomaterials Group, Department of Dentistry, Radboudumc, Geert Grooteplein Zuid 10, Nijmegen 6525GA, The Netherlands State Key Laboratory of Molecular Biology, Shanghai Key Laboratory of Molecular Andrology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, 200031, China. Department of Pediatric, Peking University People’s Hospital, Beijing 100044, China Department of Periodical Press and National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China Sichuan Industrial Institute of Antibiotics; Chengdu University; Chengdu 610052; China State Key Laboratory of Crop Stress Biology for Arid Areas, College of Plant Protection Northwest A&F University Yangling Shaanxi 712100 China Institutes of Biomedical Sciences Fudan University Shanghai China Department of Pharmacological & Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX 77204. Key Laboratory of Biomechanics and Mechanobiology (Beihang University), Ministry of Education, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing, China Department of Chemistry and Biochemistry, University of South Carolina, Columbia, South Carolina 29208, United States Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Science, National Center for Nanoscience and Technology, Beijing 100083, China. Laboratory for Molecular Photonics; Department of Chemistry; University of Miami; Coral Gables; USA Instrumental Analysis Center of Xi’an Jiaotong University, Xi’an Jiaotong University, Xi’an 710049, China Laboratory for Image and Vision Engineering, Department of Electronic and Electrical Engineering, The University of Sheffield, Sheffield, S1 3JD, United Kingdom, Department of Nephrology Chinese PLA General Hospital Medical School of Chinese PLA Chinese PLA Institute of Nephrology State Key Laboratory of Kidney Diseases National Clinical Research Center for Kidney Diseases Beijing Key Laboratory of Kidney Diseases Beijing China Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA 23298 Department of Colorectal and Anal Surgery Hepatobiliary and Enteric Surgery Center, Xiangya Hospital, Central South University Changsha China State Key Laboratory of Materials-Oriented Chemical Engineering, College of Chemical Engineering, Nanjing Tech University, 30 Puzhu South Road, Nanjing 211816, P. R. China Gastrointestinal Pathology, Joint Pathology Center, Silver Spring, MD 20910, USA. Inner Mongolia Key Laboratory of Environmental Chemistry, College of Chemistry and Environmental Science, Inner Mongolia Normal University, Huhhot010022, China College of Resources and Environment, University of Chinese Academy of Sciences, Beijing 100049, China The Medical Department of the Xiamen University, Xiamen, Fujian 361000, P.R. China 1Institute of Aquatic Economic AnimalsSchool of Life Sciences, Sun Yat-Sen University, Guangzhou, People’s Republic of China Department of Anesthesiology, Tianjin Fourth Central Hospital No. 1 Zhongshan Road, Tianjin 300140, China. Key Laboratory of Biotechnology of Antibiotics, Ministry of Health, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China Department of Orthopedics, Yangzhou Hongquan Hospital, Yangzhou, Jiangsu Province 225000, China College of Chemistry Key Laboratory of Theoretical & Computational Photochemistry of Ministry of Education Beijing Normal University Beijing 100875 China Ministry of Education Key Laboratory for Nonequilibrium Synthesis and Modulation of Condensed Matter; Department of Applied Physics; Xi'an Jiaotong University; Xi'an 710049; China Department of Gastrointestinal Surgery, The First Affiliated Hospital, Nanchang University, Nanchang, Jiangxi 330000, P.R. China 3 Department of Computational Medicine and Bioinformatics and; 4 Department of Biological Chemistry, University of Michigan, Ann Arbor, MI 48109, USA a Department of Marine, Earth, and Atmospheric Sciences , North Carolina State University , Raleigh , NC , USA Department of Neurology the First Affiliated Hospital of Wenzhou Medical University Wenzhou Zhejiang 325027 China Jilin University, China *Department of Immunology, School of Basic Medical Sciences, and Key Laboratory of Medical Immunology of Ministry of Health, Peking University Health Science Center, Beijing 100191, China; Department of Chemistry South China University of Technology Guangzhou 510640 China Anhui Provincial Engineering Technology Research Center for Biomedical Optical Instrument, Anhui Provincial Engineering Laboratory for Medical Optical Diagnosis &Treatment Technology and Instrument, Anhui Institute of Optics and Fine Mechanics, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, 230031, China; University of Science and Technology of China, Hefei, 230026, China Shanghai Jieyue Technologies Company Limited, Shanghai, China. soaraway577@sina.com Department of Solid State Chemistry Max Planck Institute for Chemical Physics of Solids 01187 Dresden Germany Cancer Research Institute College of Medicine University of South China Chang Sheng Xi Avenue 28 Hengyang Hunan 421001 P.R. China Department of Neurology, West China Hospital, Sichuan University, Chengdu, P.R. China State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen 361021, P. R. China Department of General Surgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, China; Department of General Surgery, Yancheng City No.1 People’s Hospital, Yancheng, Jiangsu Province, China State Key Laboratories for Agrobiotechnology and College of Biological Sciences, China Agricultural University, Beijing, China; France-China Bio-Mineralization and Nano-Structure Laboratory, Beijing, China Institute of Sound and Vibration Research, Hefei University of Technology , 193 Tunxi Road, Hefei 230009, People's Republic of China i Tianjin Orthopedic Hospital, Tianjin 300211, P. R. China SINOPEC Beijing Research Institute of Chemical Industry, Beijing 100013, China College of Resource and Environment Sciences, Xinjiang University, Urumqi, Xinjiang, China East China University of Science and Technology Engineering Research Centre of Pharmaceutical Process Chemistry, Ministry of Education Shanghai Key Laboratory of New Drug Design Department of Endocrinology Peking University First Hospital Beijing P. R. China Key Laboratory of National Forestry and Grassland Administration for the Protectionand Restoration of Forest Ecosystem in Poyang Lake Basin, Jiangxi Agricultural University, Nanchang 330045, China Department of Orthopedics, Xijing Hospital, Fourth Military Medical University, 710032, Xi'an, Shaanxi, China School of Life Science, Liaocheng University, Liaocheng 252000, China State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China; University of Chinese Academy of Sciences, Beijing 100049, P. R. China Department of Spine Surgery the First Affiliated Hospital of Weifang Medical University (Weifang People's Hospital) Weifang China South China Academy of Advanced Optoelectronics, South China Normal University, Guangzhou 510006, China Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia. National Engineering Research Center for Process Development of Active Pharmaceutical Ingredients, Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, P. R. China Clinical and Research Center for Infectious Diseases, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China; Department of Dermatology, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China Department of Environmental and Occupational Health, Graduate School of Public Health, The University of Pittsburgh, 100 Technology Drive, Pittsburgh, Pennsylvania 15219, United States Shandong Provincial Key Laboratory of Animal Resistant, School of Life Sciences Shandong Normal University Jinan China Beijing Institute of Nanoenergy and Nanosystems Chinese Academy of Sciences Beijing 100083 P. R. China; CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology (NCNST) Beijing 100190 P. R. China Department of Occupational and Environmental Medicine, West China School of Public Health, Sichuan University, Chengdu 610042, China. Department of Computational Medicine and Bioinformatics, ‡Department of Internal Medicine, §Department of Human Genetics and School of Public Health, ∥Department of Electrical Engineering and Computer Science University of Michigan, Ann Arbor, Michigan 48109, United States Cellular Signaling Laboratory, Key Laboratory of Molecular Biophysics of Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei, China Laboratory for Molecular Photonics Departments of Biology and Chemistry University of Miami 1301 Memorial Drive Coral Gables FL 33146-0431 USA State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, 2999 North Renmin Road, Shanghai 201620, China Department of Fluid Machinery and Engineering, Xi'an Jiaotong University, Xianning Western Road 28, Xi'an 710049, China Department of Hematology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi’an, 710004, China The Supercomputing Center, Lanzhou University, Lanzhou, China University of Strasbourg, CNRS, ISIS UMR 7006, 8 allée Gaspard Monge, 67000 Strasbourg, France. Department of Sports Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, China. Obstetrics and Gynecology Hospital Fudan University Shanghai China; Department of Obstetrics and Gynecology Shanghai Medical College Fudan University Shanghai China Departments of Thoracic Surgery and State Key Laboratory of Genetic Engineering Fudan University Shanghai Cancer Center Shanghai China; Institute of Thoracic Oncology Fudan University Shanghai China; Department of Oncology, Shanghai Medical College Fudan University Shanghai China Department of Orthorpaedics, PLA Army Genertal Hospital, Beijing The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China Department of Medicine, Zhejiang Academy of Traditional Chinese Medicine, Hangzhou, Zhejiang, China (mainland) University of Minnesota, Minneapolis; Center for Neurobehavioral Development, University of Minnesota, Minneapolis; Center for Applied and Translational Sensory Science, University of Minnesota, Minneapolis Sichuan University, West China Hospital, Department of Neurology, Chengdu 610064, People’s Republic of China Pathology & Laboratory Medicine Division, Hebei Yanda Lu Daopei Hospital, Langfang, China; Department of Pharmacy, Beijing Friendship Hospital, Capital Medical University, Beijing,China Department of Chemistry, Zhejiang University, Hangzhou 310027, People’s Republic of China Department of Cardiology, Shunde Hospital Southern Medical University Foshan China Department of Arthroscopic Surgery; Shanghai Sixth People's Hospital; Shanghai Jiao Tong University; School of Medicine; Shanghai Department of Ophthalmology, Ruijin Hospital Affiliated Medical School Shanghai Jiaotong University Shanghai China Department of Behavioral Biology, Walter Reed Army Institute of Research, Silver Spring, Maryland. School of Chemistry and Chemical Engineering, Tianjin University of Technology, Tianjin, China Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education–Beijing), Department of Cancer Epidemiology, Peking University Cancer Hospital and Institute, Beijing, China Department of Biomaterials, Radboudumc, Nijmegen, The Netherlands. Guangxi Key Laboratory of Processing for Non-ferrous Metallic and Featured Materials, School of Resources, Environment and Materials, Guangxi University, Nanning 530004, China Department of Pharmaceutical Sciences, Shenyang Pharmaceutical University, Shenyang, Liaoning, China Department of Materials Science and the Advanced Coatings Research Center of China Educational Ministry, Fudan University, Shanghai 200433, P. R. China Department of Materials Science and Engineering, National University of Singapore, Singapore 117575, Singapore Department of Breast and Thyroid Surger, Liaocheng People’s Hospital, Liaocheng, Shandong, China (mainland) Department of Urology, Affiliated Hospital of Nanjing University of Traditional Chinese Medicine, Jiangsu Provincial Hospital of Traditional Chinese Medicine, Nanjing, PR China Xuzhou Prison Hospital of Jiangsu Province Xuzhou China Department of Mechanical Engineering, University of Maine, Orono, ME, 04469, USA Department of Clinical Research Center, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine , Guangzhou , People’s Republic of China State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen, China Authors' Affiliations: Department of 1Thoracic Surgery and; 3Department of Oncology, Shanghai Medical College, Fudan University; Department of Anesthesiology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China Department of Chemistry, University of Utah, 315 South 1400 East, Salt Lake City, Utah 84112-8500 Key Laboratory of Mariculture & Stock Enhancement in North China’s Sea, Ministry of Agriculture and Rural Affrairs, Dalian Ocean University, Dalian, Liaoning, P. R. China First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, China Department of Plastic and Cosmetic Surgery Hunan Provincial People's Hospital, The First Affiliated Hospital of Hunan Normal University Changsha China Hubei Key Laboratory of Animal Nutrition and Feed Science, Wuhan Polytechnic University, PR China; Hubei Collaborative Innovation Center for Animal Nutrition and Feed Safety, PR China Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai 200240, China Department of Systems Biology for Medicine and Institutes of Biomedical Sciences Shanghai Medical College, Fudan University Shanghai P. R. China Department of Computational Medicine & Bioinformatics University of Michigan Ann Arbor MI USA State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine; School of Public Health; Xiamen University; China Department of Clinical Laboratory, Affiliated Hongqi Hospital, Mudanjiang Medical University, Aimin District, Mudanjiang, 157011, China Center for Medical Education, China Medical University, Shenyang, China. Department of Pharmacology and Toxicology, School of Medicine, Virginia Commonwealth University, Richmond, Virginia. Program of Polymer and Color Chemistry, Department of Textile Engineering, Chemistry and Science, North Carolina State University, Raleigh, NC 27606, USA Division of Pathology & Laboratory Medicine, Hebei Yanda Lu Daopei Hospital, Langfang 065201, China Department of Infectious Disease, Zaozhuang Municipal Hospital, Zaozhuang, Shandong, People's Republic of China. Center for High Pressure Science (CHiPS); State Key Laboratory of Metastable Materials Science and Technology; Yanshan University; Qinhuangdao; China Department of Pharmacology and Toxicology, Jilin University School of Pharmaceutical Sciences, 1163 Xinmin Ave, Changchun 130021, China School of Chemistry and Chemical Engineering, Shanghai Electrochemical Energy Devices Research Center, Shanghai Jiao Tong University, Shanghai200240, People’s Republic of China Department of Laboratory Medicine, Chongqing University Cancer Hospital and Chongqing Cancer Institute and Chongqing Cancer Hospital, Chongqing 400030, P.R. China College of Chemical Engineering, Guizhou Minzu University, Guiyang 550025, China School of Food Science and Engineering, South China University of Technology, Guangzhou, China. National Center for Electron Microscopy in Beijing; School of Materials Science and Engineering; Key Laboratory of Advanced Materials of Ministry of Education of China; State Key Laboratory of New Ceramics and Fine Processing; Tsinghua University Department of Hepatobiliary Surgery, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China Department of Urology Affiliated Hospital of Nanjing University of Traditional Chinese Medicine Jiangsu Provincial Hospital of Traditional Chinese Medicine Nanjing China Medical Center for Human Reproduction, Beijing Chaoyang Hospital, Capital Medical University, Beijing, PR China Institute of Biotechnology and Food Science, Hebei Academy of Agriculture and Forestry Sciences, Shijiazhuang 050051, China State Key Laboratory of Biobased Material and Green Papermaking, Qilu University of Technology, Shandong Academy of Sciences, Jinan 250353, China Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education; Yunnan Provincial Center for Research & Development of Natural Products; School of Pharmacy, Yunnan University, Kunming 650500, P. R. China Department of Periodical Press and National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, China; Chinese Evidence-Based Medicine Center, West China Hospital, Sichuan University, Chengdu, China Department of Ophthalmology, Peking Union Medical College Hospital, Peking Union Medical College, Eye Research Center of Chinese Academy of Medical Sciences, Beijing 100730, China. zhaojialiang@medmail.com.cn School of Materials Science and Engineering Zhengzhou University Zhengzhou 450001 China Department of Nutrition and Food Hygieney School of Public Health Nantong University Nantong Jiangsu China State Key Laboratory of Environmental Chemistry and Eco-toxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China; School of Chemistry and Chemical Engineering, University of Chinese Academy of Sciences, Beijing 100049, China Wenzhou Medical College, Wenzhou, Zhejiang, People's Republic of China. Department of Orthodontics, School of Stomatology, China Medical University, Shenyang 110002, Liaoning Province, China. zhangyangcmu@yahoo.com.cn Department of Biomedical Engineering Department of Neurosurgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, 88 Jiefang Road, Hangzhou 310009, China; Clinical Research Center for Neurological Diseases of Zhejiang Province, Hangzhou 310009, China Department of General Surgery, West China Hospital, Sichuan University, Chengdu 610041, China; Colorectal Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, China Department of Biosystems Science and Engineering; ETH Zurich; Basel; Switzerland Anhui Province Key Laboratory of Biological Macro-Molecules Research, Wannan Medical College Wuhu 241001, China. Department of General Surgery, Central Theater General Hospital, Wuhan 430070, Hubei Province, China. School of Public Health, Harbin Medical University, Harbin, 150081 China School of Chemistry and Chemical Engineering Guangzhou University Guangzhou China Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA; Department of Biological Chemistry, University of Michigan, Ann Arbor, MI, USA Department of Experimental Pharmacology and Toxicology, School of Pharmaceutical Sciences, Jilin University, 1266 Fujin Road, Changchun 13002, Jilin, China *Department of Anesthesiology, University of Illinois at Chicago College of Medicine, Chicago, IL 60612;; †Department of Anesthesiology, Xuzhou Medical College, Xuzhou 221002, China; and Department of Thoracic Surgery Shanghai Cancer Center, Fudan University Shanghai China; Institute of Thoracic Oncology Fudan University Shanghai China; State Key Laboratory of Genetic Engineering, School of Life Sciences Fudan University Shanghai China; Department of Oncology, Shanghai Medical College Fudan University Shanghai China 1 Institute of Image Processing and Pattern Recognition, Shanghai Jiao Tong University, and Key Laboratory of System Control and Information Processing, Ministry of Education of China, Shanghai 200240, China, 2Department of Computational Medicine and Bioinformatics and 3Department of Biological Chemistry, University of Michigan, Ann Arbor, MI 48109, USA; 1 Institute of Image Processing and Pattern Recognition, Shanghai Jiao Tong University, and Key Laboratory of System Control and Information Processing, Ministry of Education of China, Shanghai 200240, China, 2Department of Computational Medicine and Bioinformatics and 3Department of Biological Chemistry, University of Michigan, Ann Arbor, MI 48109, USA Joint International Research Laboratory of Agriculture and Agri‐Product Safety of Ministry of Education of China, Key Laboratory of Animal Breeding Reproduction and Molecular Design for Jiangsu Province, College of Animal Science and Technology Yangzhou University Yangzhou China Cancer Research Institute, Beth Israel Deaconess Cancer Center, Harvard Medical School, Boston, MA 02215, USA.; Department of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA. Key Laboratory of Bio-resource and Eco-environment of Ministry of Education, College of Life Sciences, Sichuan University , Chengdu , China Chinese Academy of Sciences, P.R. China; University of Chinese Academy of Sciences, P.R. China; Texas A & M University, USA Department of Biomaterials, Radboudumc, P.O. Box 9101, 6500HB Nijmegen, The Netherlands Department of General Surgery, The First Affiliated Hospital of Nanchang University, Nanchang, China State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics; Center for Molecular Imaging and Translational Medicine; School of Public Health; Xiamen University; Xiamen 361102 From the Department of Pharmacology (the State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), Harbin Medical University, Harbin, China. Department of Computational Medicine and Bioinformatics University of Michigan Ann Arbor Michigan 48109; Department of Biological Chemistry University of Michigan Ann Arbor Michigan 48109 College of Modern Service, Harbin Vocational College of Science and Technology, Harbin 150300, China Jiangsu Key Laboratory of Neuropsychiatric Diseases and College of Pharmaceutical Sciences, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Soochow University, Suzhou, Jiangsu 215123, China Institutes of Biomedical Sciences, Fudan University, 138 YiXueYuan Road, Shanghai 200032, P. R. China Cancer Center, The First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China Institute of Diagnostic and Interventional Radiology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai 200233, China Medical Research Council Centre for Immune Regulation, School of Immunity and Infection, College of Medicine and Dental Sciences, University of Birmingham, Birmingham B15 2TT, England, UK 4 Department of Tumor Cell Biology & Cancer Biology Program/Comprehensive Cancer Center St. Jude Children’s Research Hospital Memphis TN USA Department of Pharmacology, School of Basic Medical Sciences, Anhui Medical University, Hefei, China. Department of Neurosurgery, The Second Affiliated Hospital of Zhejiang University Medical College, Hangzhou, Zhejiang 310009, P.R. China Department of Immunology, Key Laboratory of Immune Microenvironment and Diseases, State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, Jiangsu, China 1 Department of Periodical Press and National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, Sichuan, P.R. China; Chinese Evidence-Based Medicine Center, West China Hospital, Sichuan University, Chengdu, Sichuan, P.R. China WuXi AppTec (Shanghai) Co., Ltd., 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131, P. R. China Department of Respiratory Medicine, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China; and Beijing Institute of Nanoenergy and Nanosystems Chinese Academy of Sciences Beijing 100083 China 2 Department of Computational Medicine and Bioinformatics, 100 Washtenaw Avenue, Ann Arbor, MI 48109, USA; 4 Department of Biological Chemistry, 100 Washtenaw Avenue, Ann Arbor, MI 48109, USA Minhang Hospital and Institutes of Biomedical Sciences; Fudan University; Shanghai; P. R. China Department of Neurology, Xuzhou Central Hospital, Xuzhou, Jiangsu Province, China Department of Histology and Embryology School of Basic Medicine Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China Department of Computational Medicine and Bioinformatics, Ann Arbor, MI 48109, USA; Department of Biological Chemistry, University of Michigan, Ann Arbor, MI 48109, USA Department of Neurology , West China Hospital of Sichuan University , Wainan Guoxue Xiang #37 , Chengdu 610041 , China School of Artificial Intelligence, University of Chinese Academy of Sciences, Beijing 100049, China; The Laboratory of Cognitive and Decision Intelligence for Complex System, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China Institute of Modern Optics & Tianjin Key Laboratory of Micro-Scale Optical Information Science and Technology, Nankai University, Tianjin 300071, People’s Republic of China Department of Histology and Embryology, Shanxi Medical University, Jinzhong 030604, Shanxi, China; College of Biomedical Engineering, Taiyuan University of Technology, Taiyuan 030024, Shanxi, China Ministry of Education Key Laboratory for Nonequilibrium Synthesis and Modulation of Condensed Matter, Department of Applied Physics, Xi’an Jiaotong University, Xi’an 710049, China Division of Pharmacy Practice, School of Pharmacy, University of Wisconsin (UW)— Madison |
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