http://rdf.ncbi.nlm.nih.gov/pubchem/author/MD5_840554fd804bcf7f3b216d8999d37ed2
Outgoing Links
Predicate | Object |
---|---|
family-name | Li Hua Li |
name | Hua Li |
given-name | Hua |
organization-name | University of Illinois at Urbana-Champaign, Department of Bioengineering, Urbana, Illinois State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences,1295 DingXi Road, Shanghai 20005095, People's Republic of China College of Chemistry, Chemical Engineering and Materials Science Collaborative Innovation Center of Suzhou Nano Science and Technology Soochow University Suzhou 215123 China Sir Run Run Shaw Hospital, Zhejiang University School of Medicine , Hangzhou , China Department of Pharmacology, School of Pharmacy, Tongji Medical College,Huazhong University of Science and Technology,Wuhan,China Department of Nursing, School of Stomatology, Peking University, Beijing, China Department of Neurology 3201 Hospital Xi'an Jiaotong University Health Science Center Hanzhong China Department of Basic and Forensic Medicine, Sichuan University, Chengdu, Sichuan 610041, P.R. China Authors' Affiliations: 1Center for Human Genetic Research; 2Department of Neurology, Molecular Neuro-Oncology Laboratory, Division of Neuropathology, Massachusetts General Hospital, Boston, Massachusetts; and 3Department of Molecular Genetics and Microbiology, University of Florida, Gainesville, Florida National Engineering Laboratory for Methanol-to-Olefins, Dalian National Laboratory for Clean Energy, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 116023 Dalian, China Liver Transplant Center, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China (mainland) Division of Radiation and Cancer Biology, Department of Radiation Oncology, University of Michigan, Ann Arbor, MI 48109; Department of General Surgery, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi'an, Shaanxi 710004, China Department of Vaccine and Diagnostics, The Institute of Medical Biology Chinese Academy of Medical Sciences and Peking Union Medical College Kunming Yunnan China Department of Biomedical Engineering, School of Engineering, China Pharmaceutical University, 639 Longmian Road, Jiangning District, Nanjing 210009, China College of Chemistry, Chemical Engineering and Materials Science, Collaborative Innovation Center of Suzhou Nano Science and Technology Soochow University Suzhou 215123 P. R. China Key Laboratory of Synthetic and Natural Functional Molecule of the Ministry of Education, College of Chemistry & Materials Science, Northwest University, Xi’an 710127, China; College of Chemistry and Chemical Engineering, Xi’an Shiyou University, Xi’an 710065, China Authors' Affiliations: Departments of 1Pharmacology and Toxicology, 2Surgery, 3Pathology, and 4Medicine; and 5Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Hanover, and Dartmouth-Hitchcock Medical Center, Lebanon, New Hamphshire; 6Molecular Therapeutics/Drug Discovery Program, University of Pittsburgh Cancer Institute; 7Department of Pharmaceutical Sciences, University of Pittsburgh School of Pharmacy, Pittsburgh, Pennsylvania; and 8MD Anderson Cancer Center, Houston, Texas The Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming, People’s Republic of China Department of Infectious Disease Department of Pathology and Laboratory Medicine, Albany Medical Center, Albany, NY Key Laboratory of Mesoscopic Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China. Beijing Institute of Pharmacology and Toxicology Department of Anesthesiology, Shanghai Dahua Hospital of Shanghai Xuhui District Hospital Shanghai 200237, China. Department of Otorhinolaryngology Head and Neck Surgery, The First Affiliated Hospital of Guangxi Medical University, No. 6, Shuangyong Street, Nanning 530021, P.R. China Peking University, Beijing, China. HUL@novonordisk.com From the Departments of Pediatrics (Cardiology) (Drs Towbin and Li), Cardiovascular Sciences (Drs Towbin and Wang), and Molecular and Human Genetics (Dr Towbin), Texas Children's Hospital and Baylor College of Medicine, Houston, Tex. Graduate School of Science and Technology, Kobe University, Japan State Key Laboratory of Metal Matrix Composites School of Materials Science and Engineering Shanghai Jiao Tong University 800 Dongchuan Road Shanghai 200240 P. R. China Department of Otolaryngology—Head and Neck Surgery University of California San Francisco San Francisco California USA Department of Nephrology, Sir Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China State Key Laboratory of Metal Matrix Composites, School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240, China Department of Anatomy, West China School of Predinical and Forensic Medicine, Sichuan University, Chengdu 610041 China. Department of Hepatic Surgery, the Third Affiliated hospital, Sun Yat-san University, Guangzhou 510630, China Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, P.R. China Department of Plastic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China Department of Math & Computer Science, University of Lethbridge, Canada State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan 430070, China. lh861218@163.com Department of Neurology Jinling Hospital Nanjing China Department of Hepatic Surgery, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510630, China. School of Business Administration, University of Science and Technology Liaoning, Anshan, Liaoning, China College of Chemistry, Chemical Engineering and Materials Science Collaborative Innovation Center of Suzhou Nano Science and Technology Soochow University Suzhou 215123 P. R. China Biological Carcinogenesis and Development Program, PRI/DynCorp, National Cancer Institute, Frederick Cancer Research and Development Center, Frederick, Maryland 21702-1201 Vanderbilt University Institute of Imaging Science Vanderbilt University Nashville Tennessee; Deparment of Physics and Astronomy Vanderbilt University Nashville Tennessee Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, Missouri 63110 Washington University in St. Louis, St. Louis, MO, USA Department of Critical Care Medicine, Linzi District People's Hospital, Zibo, Shandong 255400, P.R. China Department of Oncology, Jinan Central Hospital, Shandong University, Jinan, Shandong 250013, P.R. China Department of Neurosurgery, Shaanxi Fourth People’s Hospital, Xi’an, P.R. China Institute of Epidemiology & Preventive Medicine, College of Public Health National Taiwan University Taipei Taiwan Key Laboratory for Animal Disease-Resistance Nutrition of the Ministry of Education of China, Key Laboratory for Animal Disease-Resistance Nutrition and Feed of the Ministry of Agriculture of China, Key Laboratory of Animal Disease-Resistant Nutrition of Sichuan Province, Animal Nutrition Institute, Sichuan Agricultural University, Chengdu, China Department of Gynecology The Affiliated Taian City Central Hospital of Qingdao University Taian Shandong Province China Department of Natural Medicine, School of Pharmacy, Fourth Military Medical University, Xi’an 710032, China; Collaborative Innovation Center for Chinese Medicine in Qinba Moutains, 169 West Changle Road, Xi’an 710032, China Department of Cardiac Ultrasonography, The Fourth Affiliated Hospital of Xinjiang Medical University Urumqi 830000, China. Key Laboratory of Marine Materials and Related Technologies, Zhejiang Key Laboratory of Marine Materials and Protective Technologies, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences 2 , Ningbo 315201, China Shanghai Center for Systems Biomedicine; State Key laboratory on Oncogenes and Bio-ID Center; School of Biomedical Engineering; Shanghai Jiao Tong University; Shanghai 200240 Authors' Affiliations: Departments of 1Pharmacology and Toxicology and 2Surgery, Dartmouth Medical School, Hanover, New Hampshire; 3Department of Genetic Medicine, Weill Medical College of Cornell University, New York, New York; 4Bay Paul Center in Comparative Molecular Biology & Evolution, Marine Biological Laboratory, Woods Hole, Massachusetts; and 5Section of Biostatistics and Epidemiology, Department of Community and Family Medicine, Dartmouth Medical School; 6Norris Cotton Cancer Center, Lebanon, New Hampshire The Key Laboratory of Biomedical Information Engineering of Ministry of Education, Center for Mitochondrial Biology and Medicine, School of Life Science and Technology and Frontier Institute of Life Science, FIST, Xi'an Jiaotong University, Xi'an, China. 1University of Pittsburgh Cancer Institute, and Departments of Pathology and Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, Pennsylvania and Yunnan University of Chinese Medicine, Kunming, China; The First Affiliated Hospital of Yunnan University of Chinese Medicine, Kunming, China College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, P. R. China School of Public Health, Jilin University, No. 1163, Xinmin Street, Chaoyang District, Changchun, Jilin 130000, China; Department of Abdominal Ultrasound, Jilin University First Hospital, No. 1, Xinmin Street, Chaoyang District, Changchun, Jilin 130000, China Health Science Center, Peking University, Beijing, China State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu, P.R. China; China Agricultural Vet Biology and Technology limited liability company, Lanzhou, Gansu, P.R. China Department of Rehabilitation, The First Affiliated Hospital of Anhui Medical University , Hefei, Anhui Province , China Soochow University College of Chemistry Chemical Engineering and Materials Science No. 199 Renai Road, Suzhou Industrial Park Suzhou, Jiangsu 215123 P.R. China The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Ophthalmology and Chongqing Eye Institute; Chongqing P. R. China Brentwood Industries, Inc., 610 Morgantown Road, Reading, PA, USA Radiotherapy laboratory Shenzhen United Imaging Research Institute of Innovative Medical Equipment Shenzhen China Key Laboratory of Plant Resources Institute of Botany Chinese Academy of Sciences Beijing 100093 China; University of Chinese Academy of Sciences Beijing 100049 China Jiangxi Province Key Laboratory Medicine, Department of Clinical Laboratory, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, China Geriatric Research, Education and Clinical Center, Department of Veterans Affairs Medical Center, Gainesville 32608-1197; and Department of Pharmacology and Therapeutics, University of Florida College of Medicine, Gainesville, Florida 32610 Key Laboratory of Marine Materials and Related Technologies, Zhejiang Key Laboratory of Marine Materials and Protective Technologies, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo 315201, China and Cixi Institute of Biomedical Engineering, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo 315201, China Fifth Department of Gynecology, Affiliated Tumor Hospital of Xinjiang Medical University, Urumqi, Xinjiang Uyghur, People’s Republic of China Department of Radiation Oncology Washington University St. Louis MO USA Department of Psychology, University of Delaware, Newark, DE 19716 The Fishery Institute of the Sichuan Academy of Agricultural Sciences, Sichuan Provincial Laboratory for Natural Resources Protection and Sustainable Utilization, Chengdu, China and Department of Chinese Materia Medica and Natural Medicines, Air Force Medical University, Xi'an, Shaanxi 710032, P.R. China Department of Anesthesiology, Shanghai Pulmonary Hospital, Tongji University, School of Medicine, Shanghai, China; Department of Anesthesiology, Shanghai Pulmonary Hospital, Tongji University, School of Medicine, Shanghai, China Plant Pathology Department, University of Kentucky, Lexington, Kentucky 40546 Vanderbilt University Institute of Imaging Science Vanderbilt University Nashville Tennessee USA; Department of Physics and Astronomy Vanderbilt University Nashville Tennessee USA College of Chemistry and Chemical Engineering, Xi’an Shiyou University, Xi’an 710065, P. R. China Department of Biotherapeutics Discovery, Research Division, Boehringer Ingelheim Pharmaceuticals, Inc. Ridgefield, Connecticut National Center for Protein Science Shanghai, State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yueyang Road, Shanghai, 200031, China. Key Laboratory of Structure-Based Drug Design and Discovery Wuya College of Innovation Ministry of Education Shenyang Pharmaceutical University Shenyang China; Institute of Structural Pharmacology & TCM Chemical Biology College of Pharmacy Fujian University of Traditional Chinese Medicine Fuzhou 350122 China Department of Anesthesiology, Shanghai Pulmonary Hospital Shanghai, 200433, China. School of Medicine, Huzhou University, Huzhou, Zhejiang 313000, P.R. China Department of Cardiology Beijing TongRen Hospital Beijing China Key Laboratory of Plant Resources, Institute of Botany, Chinese Academy of Sciences, Beijing 100093, China; University of Chinese Academy of Sciences, Beijing 100049, China Department of Plastic Surgery, Sir Run Run Shaw Hospital, Medical School of Zhejiang University, Hangzhou, China Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100094, China. lixian78101@163.com College of Nursing University of Saskatchewan Saskatoon Saskatchewan Canada College of Chemistry Chemical Engineering and Materials Science Collaborative Innovation Center of Suzhou Nano Science and Technology National Center for International Research Soochow University Suzhou 215123 P. R. China Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China Institute for Biomedical Sciences of Pain, Capital Medical University, Beijing 100069, PR China Yongchuan Hospital Chongqing Medical University Chongqing China Neonatal Department, Maternal and Child Health Hospital of Hubei Province Tongji Medical College, Huazhong University of Science and Technology Wuhan Hubei China Department of Obstetrics and Gynecology, Second Xiangya Hospital of Central South University, Changsha 410011, China. Research Center for Cell Fate Control, College of Pharmacy, Sookmyung Women's University, Seoul, Korea. State Key Laboratory of Toxicology and Medical Countermeasures, Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing 100850, China Tongzhou District Center for Disease Control and Prevention, Beijing, China. Department of Pathogen Biology and Experimental Teaching Centre of Preventive Medicine, Key Laboratory of Prevention and Control for Emerging Infectious Diseases of Guangdong Higher Institutes, Key Laboratory for Tropical Disease Research of Guangdong Province, School of Public Health, Southern Medical University, Guangzhou, China; National Center for Protein Science Shanghai, State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China 3 Key Laboratory of Organic Synthesis of Jiangsu Province; School of Chemistry; Chemical Engineering and Materials Science; Soochow University (DuShuHu Campus); Suzhou, China Department of Ultrasound Medicine, The Thrid Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, People’s Republic of China Shenzhen United Imaging Research Institute of Innovative Medical Equipment, Shenzhen, Guangdong Province, P.R. China The First Affiliated Hospital of Chongqing Medical University Chongqing Key Laboratory of Ophthalmology and Chongqing Eye Institute, Chongqing, China 2Department of Ophthalmology, Yongchuan Hospital, Chongqing Medical University, Chongqing, China School of Molecular Sciences The University of Western Australia Perth Western Australia 6009 Australia; Centre for Microscopy Characterisation and Analysis The University of Western Australia Perth Western Australia 6009 Australia Digital Fujian Institute of Big Data for Agriculture and Forestry, Key Laboratory of Smart Agriculture and Forestry, Fujian Agriculture and Forestry University, Fuzhou 350002, China Sir Run Run Shaw Hospital, Zhejiang University School of Medicine Department of Biochemistry and Biophysics, School of Medicine, Gifu University, 40 Tsukasa-machi, Gifu 500-8705, Japan, Department of Molecular Science, Graduate School of Science and Technology, Kobe University, 1-1 Rokkodai-cho, Nada-ku, Kobe 657-8501, Japan, and Departments of Neurology, Biochemistry and Biophysics, and Pharmaceutical Chemistry and Institute for Neurodegenerative Diseases, University of California, San Francisco, California 94946-0446 Department of Emergency, Henan Traditional Chinese Medicine Hospital, Zhengzhou, Henan Department of Geriatric Cardiology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China 4MacroGenics, Inc., Rockville, Maryland. Department of Neurology, Yanbian University Hospital, Yanji, Jilin 133000, P.R. China Department of Gynecology, Beijing Obstetrics and Gynecology Hospital Capital Medical University Beijing China; Beijing Maternal and Child Health Care Hospital Beijing China Department of Gynecologic Oncology, Cancer Hospital (Institute), Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100021, China. Department of Pharmacology Toxicology and Therapeutics University of Kansas Medical Center Kansas City KS USA College of Chemistry, Chemical Engineering and Materials Science Collaborative Innovation Center of Suzhou Nano Science and Technology Institution Soochow University Suzhou 215123 P. R. China Department of Radiation Oncology; Washington University School of Medicine; St. Louis MO USA College of Materials Science and Engineering; Qingdao University of Science & Technology; Qingdao 266042; PR China College of Food Science and Engineering, Henan University of Technology Department of Ophthalmology The Second People's Hospital of Yunnan Province and The Fourth Affiliated Hospital of Kunming Medical University Kunming Yunnan China Department of Obstetrics and Gynecology, Fujian Maternity and Child Health Hospital, Affiliated Hospital of Fujian Medical University, Fuzhou, China Department of Anesthesiology, Shanghai Pulmonary Hospital, Shanghai, China (mainland) Department of Hepatic Surgery and Liver transplantation Center of The Third Affiliated Hospital, Organ Transplantation Institute, Sun Yat-sen University; Organ Transplantation Research Center of Guangdong Province, Guangzhou, Guangdong, China (mainland) Key Laboratory of Intelligent Information Processing Institute of Computing Technology Chinese Academy of Sciences Beijing China Priority Research Centre for Advanced Fluids and Interfaces, The University of Newcastle, Callaghan, New South Wales 2308, Australia Institute of Epidemiology and Preventive Medicine, College of Public Health National Taiwan University Taipei Taiwan State Key Laboratory of Metal Matrix Composites School of Materials Science and Engineering Shanghai Jiao Tong University Shanghai 200240 P. R. China Key Laboratory of Mesoscopic Chemistry of MOE School of Chemistry and Chemical Engineering Nanjing University Nanjing 210023 P. R. China Department of Plastic and Reconstructive Surgery, Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China Department of Obstetrics and Gynecology Tai'an City Central Hospital Tai'an City China Department of Radiation Oncology Washington University St. Louis MO College of Enology, Northwest University of Agriculture & Forestry, Yangling 712100, China. putj@263.net Division of Hormone Research (H.L., B.D., Z.-X.Y., V.P.), Departments of Cell Biology, Pharmacology, and Neuroscience, Georgetown University School of Medicine, Washington, DC 20007; 3Department of Structural Biology, Van Andel Institute, Grand Rapids, MI College of Pharmacy; Dalian Medical University; Western 9 Lvshunnan Road, Lvshunkou District Dalian Liaoning Province 116044 China Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China Department of Infectious Diseases, Affiliated Hospital of Hebei Engineering University, Handan 056002, China The key Laboratory of Cellular and Molecular Evolution, Kunming Institute of Zoology, the Chinese Academy of Sciences, Kunming 650223, China. okhua@yahoo.com.cn School of Chemical Engineering, Northwest University, Xi’an 710069, China Division of Hormone Research, Departments of Cell Biology and Pharmacology and Neuroscience, Georgetown University School of Medicine, Washington, DC. 20007 Center for Prostate Disease Research, Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA From the Department of Pediatrics, Toyama Medical and Pharmaceutical University, Toyama (F.I., S.T., K.U., T.M.), and Department of Pediatrics, Shimane Medical University (N.H.), Japan; the Departments of Molecular and Human Genetics (K.R.B., J.A.T.), Pediatrics (Cardiology) (W.J.D., H.L., N.E.B., J.A.T.), and Cardiovascular Sciences (J.A.T.), Baylor College of Medicine, Texas Children’s Hospital, Houston, Tex; and the Children’s Hospital at St Joseph’s, Paterson, NJ (J.M.). Landing Cloud Medical Laboratory Co. Wuhan China State Key Laboratory of Plant Physiology and Biochemistry, Department of Plant Sciences, College of Biological Sciences, China Agricultural University, Beijing 100094, China (T.M., L.J., H.L., M.Y.); and Section of Plant Biology, University of California, Davis, California 95616 (B.L.) Yunnan University of Traditional Chinese Medicine College of Chemistry, Chemical Engineering and Materials Science, Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou 215123, China Division of Radiation and Cancer Biology, Department of Radiation Oncology, University of Michigan, Ann Arbor, MI 48109, USA Center for Mitochondrial Biology and Medicine, The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology and Frontier Institute of Science and Technology, Xi’an Jiaotong University, Xi’an 710049, China; Tianjin Key Laboratory of Exercise Physiology and Sports Medicine, Tianjin University of Sport, Tianjin 300381, China Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110 School of Nursing, Peking University, 38 Xueyuan Road, Haidian District, Beijing 100191, China School of Economics and Management, Xidian University, Xi’an 471000, China Department of Physiology, University of Texas Southwestern Medical Center, Dallas, TX 75390–9040, USA.; Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390–9040, USA. School of Materials and Energy, Lanzhou University, Lanzhou 730000, China Authors' Affiliations: Departments of 1Otolaryngology, 2Biostatistics, and 3Pharmacology & Chemical Biology, University of Pittsburgh School of Medicine; 4University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania; 5The Broad Institute of Harvard and MIT, Cambridge; 6Department of Medical Oncology; and 7Center for Cancer Genome Discovery, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts Department of Pediatrics, Baylor College of Medicine Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, College of Chemistry and Materials Science, Northwest University, Xi’an 710069, China Institute of Medical Biology Chinese Academic Medical Sciences and Peking Union Medical College Kunming China; Key Laboratory for Vaccine Research and Development of Major Infectious Diseases in Yunnan Province Kunming Yunnan China Department of Orthopaedics Shanghai Ninth People's Hospital, Shanghai Key Laboratory of Orthopaedic Implant, Shanghai Jiao Tong University School of Medicine 639 Zhizaoju Road Shanghai China From the Departments of Physiology (D.A.L., A.N., D.W., C.L., A.J.L., J.T., J.N.W., P.P.) and Medicine, Division of Cardiology (D.A.L., A.N., M.C., R.M., J.N.W., P.P., M.C.D.), David Geffen School of Medicine at University of California, Los Angeles; Science for Life Laboratory, Royal Institute of Technology, Stockholm, Sweden (J.O., F.P., E. Larson, J.M., E. Lundberg, M.U.); Department of Pediatric and Adult Congenital Cardiac Surgery, Miller Children’s Hospital and Long Beach Memorial Hospital, CA... Shandong Provincial Key Laboratory of Animal Resistance Biology, College of Life Sciences, Shandong Normal University, Jinan, China School of Life Science and Engineering, Foshan University, Foshan, China State Key Laboratory of MMCs, School of Materials Science and Engineering, Shanghai Jiaotong University, Shanghai 200240, China China Wine Industry Technology Institute, Yinchuan, Ningxia, China. College of Chemistry Chemical Engineering and Materials Science Collaborative Innovation Center of Suzhou Nano Science and Technology Soochow University Suzhou 215123 China Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China. lihua621@hotmail.com Laboratoire de Recherche en Matériaux et Micro-spectroscopies Raman et FTIR; Université de Moncton; Shippagan; Canada Key Laboratory of Ecology and Environment in Minority Areas, Minzu University of China, National Ethnic Affairs Commission, Beijing 100081, China; College of Life and Environmental Sciences, Minzu University of China, Beijing 100081, China Department of Physiology and Pathophysiology, Key Laboratory of Molecular Cardiovascular Sciences of Education Ministry, Peking University Health Science Center, Beijing 100191, China. State Key Laboratory of Plant Genomics and National Center for Plant Gene Research (Beijing), Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100049, China Key Laboratory of Structure-Based Drug Design & Discovery, School of Traditional Chinese Materia Medica, Wuya College of Innovation, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China; School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai 200032, China; Research & Development Center, Shandong Buchang Pharmaceutical Company, Limited, Heze 274000, China Center for Molecular Imaging and Translational Medicine; State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics; School of Public Health; Xiamen University; 361102 Xiamen Department of Gynecology and Obstetrics Chengdu Jin Jiang Hospital for Women and Children Health Chengdu China Department of Anatomy, School of Basic Medical Sciences, Southern Medical University; Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University, School of Medicine Stowers Institute for Medical Research, Kansas City, MO 64110; Department of Infectious Disease The First Affiliated Hospital of Zhengzhou University Zhengzhou Henan P.R. China Department of Otolaryngology and Head and Neck Surgery, University of California San Francisco, San Francisco, California. Integration Application Center, Institute of Computing Technology, Chinese Academy of Sciences, Beijing, China. Department of Public Health Sciences, Division of Biostatistics, Biostatistics Collaboration and Consulting Core, University of Miami Miller School of Medicine, Miami, Florida, USA Department of Radiology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA. Department of Biochemistry and Molecular Biophysics, Box 8231, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, Missouri 63110 State Key Laboratory of Toxicology and Medical Countermeasures; Beijing China; Beijing Institute of Pharmacology and Toxicology; Beijing China Department of Gynecology and Obstetrics Ji’nan Maternity and Child Care Hospital Ji’nan Shandong China University of Tennessee Health Science Center, Memphis, Tennessee Department of Cardiac Surgery, Zhongshan Hospital Fudan University Shanghai China Department of Anatomy and Neurobiology, Xiangya School of Medicine, Central South University, Changsha 410013, Hunan Province, China ; Department of Histology and Embryology, Hunan University of Traditional Chinese Medicine, Changsha 410208, Hunan Province, China. College of Chemistry, Chemical Engineering and Materials Science Collaborative Innovation Center of Suzhou Nano Science and Technology National United Engineering Laboratory of Functionalized Environmental Adsorption Materials Soochow University Suzhou 215123 P. R. China Bio‐ID Center School of Biomedical Engineering Shanghai Jiao Tong University Shanghai China Institute of Imaging Science; Vanderbilt University; Nashville TN USA; Department of Physics and Astronomy; Vanderbilt University; Nashville TN USA University of Florida Genetics Institute, University of Florida Gainesville 1Department of Otolaryngology, University of Pittsburgh, Pittsburgh, Pennsylvania. Taian City Central Hospital, Taian, China Department of General Surgery The Second Affiliated Hospital of Xi'an Jiaotong University Xi'an China Department of Cell Biology, Georgetown University Medical Center, Washington, D.C. 20007 Department of Pediatrics, The First Affiliated Hospital of Jinan University, Guangzhou 510630, China Vanderbilt University Institute of Imaging Science Vanderbilt University Medical Center Nashville TN USA Institute of Polymer Science and Engineering; Hebei University of Technology; Tianjin 300130; P. R. China Key Laboratory of Stem Cell Engineering and Regenerative Medicine of Fujian Province University Fujian Medical University Fuzhou P. R. China; Department of Anatomy Histology, and Embryology School of Basic Medical Sciences Fujian Medical University Fuzhou P. R. China Center for Mitochondrial Biology and Medicine, The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology Xi'an Jiaotong University Xi'an 710049 China Key Laboratory for Magnetism and Magnetic Materials of the Ministry of Education, Lanzhou University; Lanzhou; P. R. China Fifth Surgical Department, Penglai People's Hospital Yantai, Shandong Province, China. Department of Obstetrics Jinan Zhangqiu District People's Hospital Jinan China Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences Beijing 100700 China; State Key Laboratory of Dao‐di Herbs China Academy of Chinese Medical Sciences Beijing 100700 China School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China Collaborative Innovation Center of Suzhou Nano Science and Technology College of Chemistry, Chemical Engineering and Materials Science Soochow University 199 Ren'ai Road Suzhou 215123 P. R. China Vanderbilt University Institute of Imaging Science Nashville Tennessee USA; Department of Radiology and Radiological Sciences Vanderbilt University Nashville Tennessee USA Dept. of Food Science and Technology Chung‐Ang Univ. Gyeonggi 456‐756 South Korea Affiliated Provincial Hospital of Anhui Medical University, China, Lujiang Road 17, Hefei, Anhui Province 230001, PR China College of Chemistry, Chemical Engineering and Materials Science Collaborative Innovation Center of Suzhou Nano Science and Technology Soochow University Suzhou 215123 P.R. China), Fax: (+86) 512-658-803-67 a School of Materials Science and Engineering, Tianjin University, Tianjin 300072, P. R. China; Tianjin Key Laboratory of Composite and Functional Materials, Tianjin University, Tianjin 300072, P. R. China Department of Biology, Brookhaven National Laboratory, Upton, NY 11973-5000 Shandong Provincial Key Laboratory of Animal Resistance Biology, College of Life Science, Shandong Normal University, Jinan, China Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, College of Chemistry and Materials Science, Northwest University, Xi’an, Shaanxi 710127, P. R. China; College of Chemistry and Chemical Engineering, Xi’an Shiyou University, Xi’an, Shaanxi 710065, P. R. China Materials Characterization and Preparation Center, Southern University of Science and Technology, Shenzhen 518055, People’s Republic of China School of Molecular Sciences, The University of Western Australia, Perth, Western Australia, Australia College of Resources and Environment, Southwest University, Chongqing 400716, China. 1056307239@qq.com China State Institutes of Pharmaceutical Industry National Shanghai Center for New Drug Safety Evaluation and Research, Shanghai, China; Shanghai InnoStar Bio-Tech Co., Ltd., 199 Guoshoujing Road, Pilot FreeTrade Zone, Shanghai 201203, China Department of Pathogen Biology and Experimental Teaching Centre of Preventive Medicine, Key Laboratory of Prevention and Control for Emerging Infectious Diseases of Guangdong Higher Institutes, Key Laboratory for Tropical Disease Research of Guangdong Province, School of Public Health, Southern Medical University, Guangzhou, 510515, China. Authors' Affiliations: 1Division of Radiation and Cancer Biology, Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan; and 2Millennium Pharmaceuticals, Inc., Cambridge, Massachusetts Shandong Provincial Key Laboratory of Animal Resistance Biology, College of Life Sciences, Shandong Normal University, Jinan 250014, China Department of Internal Medicine, Laizhou People's Hospital, Laizhou City, PR China Department of Gastrointestinal Surgery, Tangshan Central Hospital, Tangshan, China Department of Pharmacology, College of Pharmacy, Dalian Medical University, Dalian, Liaoning, China; Department of Oncology, The Affiliated Hospital of Binzhou Medical University, Binzhou, Shandong, China College of Food Science and Engineering Henan University of Technology Zhengzhou China Stowers Institute for Medical Research Kansas City MO USA Department of Elderly Endocrinology, First Affiliated Hospital, Zhengzhou University, Zhengzhou, China University of Tennessee Health Science CenterMemphisTennesseeUSA Department of Anatomy, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu 610041, China. Vanderbilt University Institute of Imaging Science Vanderbilt University Nashville Tennessee USA; Department of Radiology and Radiological Sciences Vanderbilt University Nashville Tennessee USA School of Sciences; Nantong University; Nantong 226019; China Department of Cardiology, Beijing Tongren Hospital, China (H.L.). 2State Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China From the Departments of Cardiovascular Pharmacology (J.T.P., H.L., T.M.A.B.), Pharmacokinetics and Drug Metabolism (H.H.), Biochemistry (L.J.), and Chemistry (P.M.O., D.R.S.), Pfizer Global Research and Development, Ann Arbor, Mich; and Cardiothoracic Surgery, Medical University of South Carolina, Charleston (M.L.C., T.E., F.G.S.). Institute of Medical Biology, Peking Union Medical College, Chinese Academy of Medical Science, Beijing 100730, China. huali10101@163.com Department of Clinical Laboratory, The Second Affiliated Hospital of Nanchang University, Jiangxi Province Key Laboratory of Laboratory Medicine, Nanchang 330006,China School of Graduate Study University of Chinese Academy of Sciences Beijing 100049 China; Key Laboratory of Terahertz Solid State Technology Shanghai Institute of Microsystem and Information Technology Chinese Academy of Sciences Shanghai 200050 China Ian Wark Research Institute, University of South Australia, Mawson Lakes 5095, Australia Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China; Singapore Centre for 3D Printing Department of Mechanical and Aerospace Engineering Nanyang Technological University Singapore 639798 Singapore Department of Oncology, Hangzhou Third People's Hospital, Hangzhou, Zhejiang 310009, P.R. China Department of Gastroenterology, Affiliated Xiamen First Hospital Fujian Medical University, Xiamen, Fujan, 361003 PR China. Liver Transplantation Center, The Third Affiliated Hospital Sun Yat-Sen University, Guangzhou 510630, China State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied Chemistry, Chinese Academy of Sciences Changchun 130022 P.R. China; University of Science and Technology of China Hefei 230026 P.R. China College of Chemistry Chemical Engineering and Materials Science Collaborative Innovation Center of Suzhou Nano Science and Technology Soochow University Suzhou 215123 P. R. China Departments of Cell Biology (V.P., H.L.), Georgetown University Medical Center, Washington, D.C. 20007 Department of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China. Bioinformatics Center, Stowers Institute for Medical Research, Kansas City, Missouri. School of Environmental and Municipal Engineering, Xi'an University of Architecture and Technology, Xi'an 710055, China. lihua19841119@163.com School of Traditional Chinese Materia Medica, Wuya College of Innovation, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China; Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China 1Pharmacology and Toxicology, Departments of State Key Laboratory of Applied Organic Chemistry College of Chemistry and Chemical Engineering Lanzhou University Lanzhou Gansu 730000 China; School of Materials and Energy Electron Microscopy Centre Lanzhou University Lanzhou Gansu 730000 China Key Laboratory of Geriatric Nutrition and Health, Ministry of Education of China School of Light Industry Beijing Technology and Business University Beijing China Authors' Affiliations: Departments of 1Otolaryngology, 2Pharmacology & Chemical Biology, 3Pathology, and 4Medicine, University of Pittsburgh School of Medicine; 5Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania; 6Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas; and 7Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts Senior Department of Orthopedics, General Hospital of Chinese PLA, Beijing, 100853, P.R.China. National Clinical Research Center for Orthopedics, Sports Medicine & Rehabilitation, Beijing, 100853, P.R.China. Center for Molecular Imaging and Translational Medicine; State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics; School of Public Health; Xiamen University; Xiamen Dep. of Environmental Engineering College of Natural Resources and Environmental Science, Zhejiang Univ. Hangzhou 310029 China College of Engineering Nanjing Agricultural University Nanjing People's Republic of China Institute of Imaging Science Department of Radiology and Radiological Sciences Vanderbilt University Medical Center Nashville Tennessee Stowers Institute for Medical Research, Kansas City, United States Pancreatic Disease Center, Department of General Surgery Ruijin Hospital, Affiliated to Shanghai Jiaotong University School of Medicine No. 197 Ruijin Er Road 200025 Shanghai People’s Republic of China College of Pharmacy, Guilin Medical University, Guilin 541004, People’s Republic of China Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, P.R. China The Third People’s Hospital of Chengdu, Affiliated Hospital of Southwest Jiao Tong University Medical School, Chengdu, China Stowers Institute for Medical Research, Kansas City, MO 1 Proctology Department, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, Guangxi, China Department of Radiation Oncology, Washington University in St. Louis, St. Louis, Missouri, USA Contribution from the Department of Chemistry, Case Western Reserve University, Cleveland, Ohio 44106-7078, Department of Biochemistry, University of Georgia, Athens, Georgia 30602, Department of Chemistry, Chemical Instrumentation Center, The Ohio State University, Columbus, Ohio 43210, Department of Neurology, Duke University Medical Center, Durham, North Carolina 27710, and Suntory Institute of Bioorganic Research, Wakayamadai, Shimamoto-cho, Mishima-gun, Osaka 618, Japan Cancer Center, The General Hospital of Western Theater Command, Chengdu, China Division of Hormone Research, Departments of Cell Biology and of Pharmacology and Neurosciences, Georgetown University Medical Center, Washington, D.C. 20057, Unité INSERM U410, Faculté de Médecine Xavier Bichat, 16 Rue Henri Huchard, 75870 Paris Cedex 18, France, and Unité INSERM U472, 16 Avenue Paul Vaillant-Couturier, Batiment INSERM, 94807 Villejuif, France Cancer Center, Chengdu Military General Hospital, Chengdu, China College of Chemistry Chemical Engineering and Materials Science Collaborative Innovation Center of Suzhou Nano Science and Technology Institution Soochow University Suzhou 215123 China Department of Otolaryngology Head and Neck Surgery,Guangdong Province Hospital of Chinese Medicine. College of Environmental and Resource Science Shanxi University Taiyuan 030006 China College of Chemistry; Chemical Engineering and Materials Science; Collaborative Innovation Center of Suzhou Nano Science and Technology; Soochow University; Suzhou Shanghai Innostar Bio-tech Co., Ltd, Shanghai Institute of Pharmaceutical Industry, Shanghai, China Department of Hepatic Surgery The Third Affiliated Hospital of Sun Yat‐sen University Guangzhou China The Co-construction Laboratory of Microbial Molecular Biology of Province Department and Ministry of Science and Technology, College of Life Sciences, Hunan Normal University, Changsha, Hunan, 410081, People’s Republic of China Institute of Chinese Materia Medica; China Academy of Chinese Medical Sciences; 16 Nanxiaojie, Dongzhimennei Ave Beijing China 1University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania. School of Materials and Energy Electron Microscopy Centre Lanzhou University Lanzhou 730000 P. R. China Key Laboratory of Mariculture, Ministry of Agriculture, Dalian Ocean University, Dalian 116023, China. lihua@dlou.edu.cn Stowers Institute for Medical Research, Kansas City, Missouri 64110, and Department of Physical Examination,Yanbian University Hospital (Yanbian Hospital), Yanji 133000, Jilin Province, China. Research Center for Cell Fate Control College of Pharmacy Sookmyung Women's University Seoul Korea 1Plant Biotechnology Group – Plant Virology, Western Australian State Agricultural Biotechnology Centre, School of Veterinary and Life Sciences, Murdoch University, Perth, WA 6150, Australia Center for Prostate Disease Research, Department of Surgery, Uniformed Services University of the Health Sciences and the Walter Reed National Military Medical Center, Bethesda, Maryland, 20814, USA; John P. Murtha Cancer Center, Walter Reed National Military Medical Center, Bethesda, Maryland, 20814, USA SUSTech Core Research Facilities, Southern University of Science and Technology, Shenzhen 518055, China Department of Oral and Maxillofacial Surgery, College of Stomatology, Hospital of Stomatology, Guangxi Medical University, Nanning, China; Guangxi Key Laboratory of Oral and Maxillofacial Rehabilitation and Reconstruction, Nanning, China; Guangxi Clinical Research Center for Craniofacial Deformity, Nanning, China Department of Biomedical Engineering, College of Engineering, China Pharmaceutical University, Nanjing 210009, China College of Environmental & Resource Science, Shanxi University, Taiyuan, People’s Republic of China Guangdong Institute for Drug Control, Guangzhou 510180, China. Key Laboratory for Biorheological Science and Technology of Ministry of Education, State and Local Joint Engineering Laboratory for Vascular Implants, Bioengineering College of Chongqing University, Chongqing 400044, China National Engineering Research Center of Lower-Carbon Catalysis Technology Dalian National Laboratory for Clean Energy Dalian Institute of Chemical Physics Chinese Academy of Sciences Dalian 116023 P. R. China Department of Emergency, Qinghai Hospital for Infectious Diseases, Xining 810000, Qinghai, China. School of National Defence Science and Technology, Southwest University of Science and Technology, Mianyang Sichuan 621010, China Wuya College of Innovation, Key Laboratory of Structure‐Based Drug Design & Discovery, Ministry of Education Shenyang Pharmaceutical University Shenyang China; College of Pharmacy Fujian University of Traditional Chinese Medicine Fuzhou China Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China Department of Parasitology, First Military Medical University, Guangzhou 510515, China. Department of Physics and Key Laboratory for Atomic and Molecular Nanosciences, Tsinghua University, Beijing, 100084, China Department of General Practice, Chongqing Qianjiang Central Hospital Chongqing 409000, China. Department of Disease Prevention and Control, Xi’an Children’s Hospital, The Children’s Hospital Affiliated to Xi’an Jiaotong University, Xi’an, Shaanxi, China Department of Obstetrics & Gynecology, The Third Hospital, Peking University, Beijing 100083, China. Key Laboratory of Optoelectronic Chemical Materials and Devices, School of Chemical and Environmental Engineering, Jianghan University, Wuhan 430056, China Tianjin Medical University, Clinical College of Ophthalmology, Tianjin Eye Hospital, Tianjin Eye Institute, Tianjin Key Laboratory of Ophthalmology and Visual Science, Tianjin 300020, China. Epilepsy Center, Guangdong 999 Brain Hospital, Guangzhou, Guangdong 510510, China. Email: lihual051@163.com. From the Diabetes Research Institute (R.D.M., T.B., H.L., P.C., A.P.,C.V., N.S.K., C.R., L.I.), University of Miami School of Medicine, Miami,Florida; and Biogen (L.C.B.), Cambridge, Massachusetts. School of Molecular Sciences, University of Western Australia, Perth, Western Australia, Australia Department of Geratology Yantai Yuhuangding Hospital Yantai 264000 Shandong China Shandong Academy of Governance Jinan Shandong Province China Shandong Provincial Key Laboratory of Animal Resistance Biology, College of Life Sciences, Shandong Normal University, Jinan, Shandong 250014, P.R. China Department of Obstetrics and Gynecology, Taian City Central Hospital, Taian, Shandong, China (mainland) Research Institute of Toxicology and Pharmacology, Academy of Military Medical Science, Beijing 100850, China. Department of Ophthalmology, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China State Key Laboratory of Applied Organic Chemistry, Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, Laboratory of Special Function Materials and Structure Design of the Ministry of Education, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China Division of GI and Hepatology, The Research Institute of Clinical Medicine, Department of Internal Medicine, Chonbuk National University Medical School and Hospital, Jeonju 561-712, Korea. Center for Evidence-Based Chinese Medicine, Beijing University of Chinese Medicine, Beijing China. From the NHLBI Proteomics Center at UCLA/NHLBI Proteomics Program (N.C.Z., Ha.L., M.P.Y.L., R.C.J., C.S.K., N.D., A.K.K., J.H.C., I.Z., D.L., J.O., T.X., J.W., H.D., M.U., J.R.Y., R.A., H.H., P.P.), and Departments of Physiology and Medicine/CVRL (N.C.Z., Ha.L., Hu.L., M.P.Y.L., C.S.K., A.K.K., J.H.C., I.Z., D.L., D.M., J.W., P.P), UCLA School of Medicine, Los Angeles, CA; College of Biomedical Engineering and Instrumentation, Zhejiang University, the Key Laboratory for Biomedical Engineering of... State Key Laboratory of Metal Matrix Composites; School of Materials Science and Engineering; Shanghai Jiaotong University; Shanghai 200240, The People's Republic of China Department of Cardiology Tsinghua University, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine Beijing China Department of Radiation Oncology School of Medicine Washington University in Saint Louis 4921 Parkview Place St. Louis MO 63110 USA Beijing Institute of Medical Device Testing, Beijing Center for Testing and Research of Medical Biological Protective Equipment, Beijing 101111, China State Key Laboratory of Fine Chemicals DUT–KTH Joint Education and Research Center on Molecular Devices Dalian University of Technology (DUT) 116024 Dalian P. R. China Institute of Materia Medica, School of Pharmacy, Fourth Military Medical University, Xi'an, China. Stowers Institute for Medical Research, Kansas City, Missouri 64110 National Research Laboratory of Lipid Metabolism and Atherosclerosis, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Korea.; Department of Biomolecular Science, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Korea University of Science and Technology, Daejeon, Korea. Department of Surgery, First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China. Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, P.R. China; Wuya College of Innovation, School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, P.R. China Department of Oncology, Chengdu Military General Hospital, Chengdu 610083, China Bio-ID Center; School of Biomedical Engineering; Shanghai Jiao Tong University; Shanghai 200240; China College of Chemistry and Chemical Engineering, Xi’an Shiyou University, Xi’an, Shaanxi 710065, People’s Republic of China Stowers Institute for Medical Research, 1000 E. 50th St, Kansas City, MO 64110, USA College of Pharmacy, Sookmyung Women’s University Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Institute of Animal Nutrition, Sichuan Agricultural University, Wenjiang District, Chengdu, Sichuan, People’s Republic of China Department of Oncology, Chengdu Military General Hospital, Chengdu 610083, Sichuan Province, China Discipline of Chemistry; The University of Newcastle; Callaghan; Australia Departments of Pediatrics and Microbiology and Immunology, Emory University, Atlanta, Georgia 30322 Experimental Teaching Center of Preventive Medicine, School of Public Health and Tropical Medicine, Southern Medical University, Guangzhou, People's Republic of China. Computational Biology, Stowers Institute for Medical Research , Kansas City, MO, USA College of Chemistry and Chemical Engineering, Graduate University of Chinese Academy of Sciences, Beijing 100049, P. R. China, and Genome Center, University of California, Davis, California 95616 Program Resources, Inc./DynCorp, NCI-FCRDC, Frederick, MD 21702-1201. College of Chemistry, Chemical Engineering and Materials Science Soochow University No.199 Renai Road Suzhou Jiangsu Sheng 215123 P. R. China Department of Hepatic Surgery, The Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, People's Republic of China Department of Neurosurgery, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, Jiangsu 210002, P.R. China Radiation Oncology, Washington University School of Medicine Saint Louis MO UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania.; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania. 2MacroGenics, Inc., Rockville, Maryland. 5th Department of Gynecology Affiliated Tumor Hospital of Xinjiang Medical University Urumqi China Shanghai Key Laboratory of Orthopaedic Implants, Department of Orthopaedics, Ninth People’s Hospital, Shanghai Jiaotong University School of Medicine, Shanghai Department of Natural Products Chemistry School of Traditional Chinese Materia Medica, Key Laboratory of Structure‐Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University Shenyang China College of Chemistry, Chemical Engineering and Materials Science; Collaborative Innovation Center of Suzhou Nano Science and Technology; National United Engineering Laboratory of Functionalized Environmental Adsorption Materials; Soochow University; Suzhou 215123 Department of Emergency, Xiangyang NO. 1 People's Hospital, Hubei University of Medcine, Xiangyang, Hubei, China Department of Chemistry, Southern University of Science and Technology, Shenzhen 518055, China Department of Tuberculosis, Beijing Chest Hospital Affiliated to Capital Medical University, Beijing Tuberculosis & Thoracic Tumor Research Institute, Beijing, China Tianjin Eye Hospital & Eye Institute Tianjin Key Lab of Ophthalmology and Visual Science, Tianjin Medical University, Tianjin, China Department of Infectious Disease, The First Affiliated Hospital of Zhengzhou University, Zhengzho 450052, Henan, China Wuya College of Innovation, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education Shenyang Pharmaceutical University Shenyang 110016 China; Institute of Structural Pharmacology & TCM Chemical Biology, College of Pharmacy Fujian University of Traditional Chinese Medicine Fuzhou 350122 China Department of Clinical Laboratory, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China (mainland) Institute of Medical Biology, Chinese Academic Medical Sciences and Peking Union Medical College, Kunming, People’s Republic of China School of Pharmacy, Wenzhou Medical College, Campus of Chashan High Education, Wenzhou, China. Department of Oral and Maxillofacial Surgery, Capital Medical University School of Stomatology, Beijing - China National Engineering Laboratory for Methanol-to-Olefins Dalian National Laboratory for Clean Energy Dalian Institute of Chemical Physics Chinese Academy of Sciences Dalian 116023 P. R. China 1MacroGenics, Rockville, Maryland. Department of Pediatrics Guangdong 999 Brain Hospital Guangzhou China Institute of Epidemiology and Preventive Medicine, National Taiwan University, Taipei, Taiwan College of Animal Science and Technology, Hebei Agricultural University, Baoding, Hebei, China College of Life Sciences, Shandong Normal University, Jinan, China College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, P.R. China Department of Nursing Care School of National Defense Science and Technology, Southwest University of Science and Technology, Mian yang 621010, China At the time of the study, all of the authors were with the University of Miami, Miami, FL. School of Environment and Resources, Shanxi University, Taiyuan, People’s Republic of China; Shanxi Laboratory for Yellow River, Taiyuan, People’s Republic of China Authors' Affiliations: Departments of 1Pharmacology and Chemical Biology, 2Pathology, 3Cell Biology and Physiology, and 4Human Genetics, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, Pennsylvania Key Laboratory of Pesticide & Chemical Biology of Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, People’s Republic of China Key Laborary of Special Function Materials and Structure Design, Ministry of Education, Department of Materials Science, School of Physical Science and Technology, National & local Joint Engineering Laboratory for Optical Conversion Materials and Technology, Lanzhou University, Tianshui South Road No. 222, Lanzhou, Gansu 730000, PR China Institute of Chinese Materia Medica China Academy of Chinese Medical Sciences Beijing China Department of Anesthesiology, Shanghai Pulmonary Hospital, Shanghai 200433, P.R. China Vanderbilt University Institute of Imaging Science Nashville Tennessee; Department of Radiology and Radiological Sciences Vanderbilt University Medical Center Nashville Tennessee College of Enology, Northwest A & F University, Yangling, China; Shaanxi Engineering Research Center for Viti-Viniculture, Yangling, China; Heyang Experimental and Demonstrational Stations for Grape, Weinan, China Institute of Genetic Engineering, Southern Medical University, Guangzhou 510515, China. li_hua@139.com State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China; University of Science and Technology of China, Hefei 230026, P. R. China Department of General Surgery Chinese People's Liberation Army General Hospital Beijing China; Department of Surgical Oncology Affiliated Xing Tai People Hospital of Hebei Medical University Xingtai Hebei China Department of Neurology, the 476th Hospital of PLA, Fuzhou, 350002, China. Department of Neurosurgery, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei China Beijing Institute of Pharmacology\remvoliss and Toxicology, No. 27 Taiping Road, Haidian District, 100850 Beijing, China State Key Laboratory of Fine Chemicals; Dalian University of Technology (DUT); DUT-KTH Joint Education and Research Center on Molecular Devices; Dalian 116024; China Biotherapeutics Discovery, Boehringer Ingelheim Pharmaceuticals, 900 Ridgebury Road, Ridgefield, CT 06877, USA School of Environmental & Life Sciences, The University of Newcastle, Callaghan, New South Wales 2308, Australia Stowers Institute for Medical Research 1000 E 50 St, Kansas City, MO 64110, USA. College of Chemistry Chemical Engineering and Materials Science, Collaborative Innovation Center of Suzhou Nano Science and Technology Soochow University Suzhou 215123 P.R. China College of Chemistry, Chemical Engineering and Materials Science; Collaborative Innovation Center of Suzhou Nano Science and Technology; Soochow University; Suzhou 215123 China State Key Laboratory of Agromicrobiology, College of Life Science and TechnologyHuazhong Agricultural University Wuhan China; National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of BiophysicsChinese Academy of Sciences Beijing China From MacroGenics, Rockville, MD. Pulmonary, Allergy and Critical Care Division, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania Department of Endocrinology, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China Department of Neurology Sichuan University West China Hospital Chengdu China Department of Neurosurgery, Tongji Hospital Tongji Medical College, Huazhong University of Science and Technology Wuhan Hubei China State Key Laboratory of Advanced Electromagnetic Engineering and Technology, School of Electrical and Electronic Engineering, Huazhong University of Science and Technology 1 , Wuhan, Hubei Province, China; Key Laboratory of Pulsed Power Technology, Huazhong University of Science and Technology, Ministry of Education 2 , Wuhan, Hubei Province, China Industrial Biomaterials Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Republic of Korea Department of Plastic & Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University, School of Medicine b School of Mechanical and Aerospace Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798, Republic of Singapore Quest Diagnostics, 33608 Ortega Highway, San Juan Capistrano, California 92690, United States The Second Affiliated Hospital, Nanchang University, Nanchang, China Department of Oral and Maxillofacial‐Head and Neck Oncology, Beijing Stomatological Hospital Capital Medical University Beijing China Bell Research Center for Reproductive Health and Center; Nagoya Japan From the J. Philip Kistler Stroke Research Center (S.L., N.S.R., L.M.B., A.C., R.E.G., T.K.T., B.T.), Department of Neurology, and Department of Radiology (H.L., G.J.H.), Massachusetts General Hospital and Harvard Medical School, Boston; Department of Neurology (M.K., K.L.F.), Rhode Island Hospital, Alpert Medical School of Brown University, Providence; Massachusetts General Hospital Biostatistics Center (A.M.), Boston; Neuroprotection Research Laboratory (K.A., A.T.S., L.-D.D.P., E.H.L.),... Department of Pharmacology, Toxicology and Therapeutics and Department of Neurology, Jinling Hospital, Nanjing University School of Medicine, Nanjing, China Department of Obstetrics Changsha Hospital for Maternal & Child Health Care Changsha Hunan Province China Authors' Affiliations: 1Women's Cancer Program and Epigenetics and Progenitor Cell Keystone Program, 2Cancer Biology Program, 3Biostatistics and Bioinformatics Facility, Fox Chase Cancer Center, Philadelphia, Pennsylvania; 4Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, Massachusetts; and 5Cancer Epigenetics Discovery Performance Unit, Oncology R&D, GlaxoSmithKline Pharmaceuticals, Inc., Collegeville, Pennsylvania J. Philip Kistler Stroke Research Center, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA; Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA 1Center for Prostate Disease Research, Department of Surgery, Uniformed Services University of the Health Sciences and Walter Reed National Military Medical Center, Bethesda, Maryland. CAS Key Lab of Separation Sciences for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China School of Materials Science and Engineering, South China University of Technology, Guangzhou 510640, China Department of Anesthesiology and Operation Room , Xinqiao Hospital, , Chongqing , China , 400038; Army Medical University , Xinqiao Hospital, , Chongqing , China , 400038 Jiangxi Province Key Laboratory of Laboratory Medicine, Department of Clinical Laboratory, The Second Affiliated Hospital of Nanchang University, Nanchang Jiangxi 330006, PR China Faculty of Informatics and Engineering, The University of Electro Communications, 1-5-1 Chofugaoka, Chofu, Tokyo 182-8585, Japan Department of Cuisine and Nutrition, Yangzhou University, Yangzhou 225127, China State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China; University of Science and Technology of China, Hefei 230026, PR China Department of Biological Sciences, Wayne State University, Detroit, MI 48202 State Key Laboratory of Fine Chemicals; DUT-KTH Joint Education and Research Center on Molecular Devices; Dalian University of Technology (DUT); 116024 Dalian; China Department of Surgical Oncology, Affiliated Xing Tai People Hospital of Hebei Medial University, Xingtai 054001, China Bio-ID Center, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China. Department of Molecular Genetics and Microbiology, University of Florida, Gainesville, FL 32610, USA Institute of Imaging Science; Vanderbilt University; Nashville Tennessee USA; Department of Physics and Astronomy; Vanderbilt University; Nashville Tennessee USA Department of Nephrology, Second Xiangya Hospital; Institute of Nephrology, Central South University, Changsha 410011, China. Department of Burns and Plastic Surgery, Shanghai Electric Power Hospital, Shanghai 200050, P.R. China. University of Illinois at Urbana–Champaign, Department of Bioengineering, Urbana, Illinois Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China Betta Pharmaceuticals Hangzhou China Department of Geriatric Taizhou People's Hospital Affiliated to Nantong University Taizhou Jiangsu China Department of Pediatrics, First Affiliated Hospital, Jinan University, Guangzhou 510632, China. songyuanzong@vip.tom.com. Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100083, China. Institute of Animal Nutrition, Sichuan Agricultural University, Chengdu 625014, China; Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Chengdu 625014, China Department of Pathology, Shanghai Medical College of Fudan University, Shanghai 200032, China. Department of Nursing, School of Medicine, Sir Run Run Shaw Hospital Zhejiang University Hangzhou China Institute of Structural Pharmacology & TCM Chemical Biology, College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian 350122, China Department of Biomedical Engineering School of Engineering China Pharmaceutical University 24 Tongjia Lane, Gulou District Nanjing 210009 China Department of Orthopedic Surgery, Harrison International Peace Hospital, Hengshui, Hebei, China (mainland) School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, P. R. China Organ Transplantation Institute of Sun Yat-Sen University Guangzhou 510630, China. Department of Plastic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, People’s Republic of China Wuya College of Innovation, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, China. Nanoelectronics Laboratory, Department of Electrical Engineering and Computer Science, University of Cincinnati, Cincinnati, Ohio 45221-0030, United States School of Medicine Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, , Shanghai Jiao Tong University, 639 Zhizaoju Rd, Shanghai 200011, P.R . China Department of Endocrinology, Diabetes and Metabolism, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV, USA Institute of High Performance Computing, National University of Singapore, 1 Science Park Road, #01-01 The Capricorn, Singapore Science Park II, Singapore 117528 Department of Immunology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan. Department of Anatomy, School of Preclinical and Forensic Medicine, Sichuan University, Chengdu 610041, China. leehua117@yahoo.com.cn Naval Aeronautical and Astronautical University, Yantai 264001, China. Department of Neurology National Center for Children's Health Beijing Children's Hospital Capital Medical University Beijing China Key Laboratory of Mesoscopic Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China Department of Otolaryngology – Head and Neck Surgery, University of California, San Francisco, San Francisco, CA 3 State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences; Department of Obstetrics and Gynecology, Peking University Third Hospital, Peking University, Beijing, China *Department of Neuroimmunology, Research Institute of Environmental Medicine, Nagoya University, Nagoya 464-8601, Japan; and State Key Laboratory of Applied Organic Chemistry, Laboratory of Special Function Materials and Structure Design of the Ministry of Education, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China College of Nursing, University of Saskatchewan, Saskatoon, SK, Canada. 1Gene Expression and Regulation Program, The Wistar Institute, Philadelphia, Pennsylvania. Capital Medical University School of Stomatology Beijing P.R. China Department of Cardiology, Affiliated Hospital of Binzhou Medical University, Binzhou, China Key Laboratory for Magnetism and Magnetic Materials of the Ministry of Education; Lanzhou University; Lanzhou; 730000 P.R. China School of Mechanical and Aerospace Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798, Singapore Department of Microbiology, College of Medicine, Kyung Hee University Department of Cardiology; The First Affiliated Hospital of Nanjing Medical University; Nanjing 210029 China Guangdong Provincial Key Laboratory of Animal Molecular Design and Precise Breeding, School of Life Science and Engineering, Foshan University, Foshan, China Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China HuaZhong University of Science and Technology (HUST) State Key Laboratory of Advanced Electromagnetic Engineering and Technology, , Wuhan 430074, China Department of Surgical Oncology, Xingtai People’s Hospital, No.16, Hongxing Street, Xingtai , 054031 , Hebei , China State Key Laboratory of Plant Genomics Institute of Genetics and Developmental Biology Chinese Academy of Sciences Beijing China Beijing Institute of Pharmacology and Toxicology Beijing China College of Chemistry, Chemical Engineering and Materials Science Soochow University Suzhou 215123 P. R. China 1First Department of Internal Medicine, Sapporo Medical University, Sapporo, Japan; Bio‐ID Center School of Biomedical Engineering Shanghai Jiao Tong University Shanghai 200240 China Department of Plastic Surgery, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Research Institute of Clinical Medicine, Biomedical Research Institute Chonbuk National University Medical School and Hospital, Jeonju, Jeonbuk, Republic of Korea Laboratoire de Recherche en Matériaux et Micro-spectroscopies Raman et FTIR; Université de Moncton-Campus de Shippagan; Shippagan; Canada; Department of Inorganic Materials College of Horticulture, FAFU-UCR Joint Center for Horticultural Biology and Metabolomics, Haixia Institute of Science and Technology, Fujian Agriculture and Forestry University, Fuzhou, 35002, China Department of Head and Neck-Plastic Surgery, Sir Run Shaw Hospital, Zhejiang University, Hangzhou 310016, China. Key Lab of Intelligent Information Processing, Institute of Computing Technology and University of Chinese Academy of Sciences, Beijing 100190, China Department of Ophthalmology Clinical Medical College of Shandong University Jinan China; State Key Laboratory Cultivation Base Shandong Provincial Key Laboratory of Ophthalmology Shandong Eye Institute Shandong First Medical University & Shandong Academy of Medical Sciences Qingdao China Department of Magnetic Resonance Imaging HYK High‐throughput Biotechnology Institute Shenzhen China College of Chemistry Chemical Engineering and Materials Science Collaborative Innovation Center of Suzhou Nano Science and Technology National United Engineering Laboratory of Functionalized Environmental Adsorption Materials Soochow University Suzhou 215123 P. R. China Key Lab of Separation Sciences for Analytical Chemistry; Dalian Institute of Chemical Physics; Chinese Academy of Sciences; Dalian; China 1 Stowers Institute for Medical Research, 1000 E 50th Street, Kansas City, MO 64110 and 2Department of Statistics, University of Michigan, Ann Arbor, MI 48105, USA Priority Research Centre for Advanced Fluids and Interfaces; The University of Newcastle; Callaghan; Australia Department of Molecular Genetics and Microbiology University of Florida College of Medicine Gainesville Florida USA Tsinghua University 1 Department of Physics and State Key Laboratory of Low-Dimensional Quantum Physics, , Beijing, 100084, China Department of Clinical Laboratory, Jiangbing Hospital of Guangxi Zhuang Autonomous Region, Nanning, PR China Research, MacroGenics, Inc., Rockville, Maryland. College of Nursing, University of Saskatchewan, Saskatoon, SK, Canada The Kidney Institute (S.L., W.T., J.R., H.L., Z.X., L.D.Q.), University of Kansas Medical Center, Kansas City, Kansas 66160 Authors' Affiliations: 1Women's Cancer Program, 2Biosample Repository Facility, and 3Epigenetics and Progenitor Cells Keystone Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China. d Emperor Qin's Terra-Cotta Warriors and Horses Museum , Xi'an, China State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China College of Chemistry Chemical Engineering and Materials Science Collaborative Innovation Center of Suzhou Nano Science and Technology Soochow University Suzhou 215123 P.R. China Department of Infectious Disease, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan, China Department of Obstetrics and Gynecology, Third Hospital, Peking University, Beijing 100083, China. huali88@sina.com The Fishery Institute of the Sichuan Academy of Agricultural Sciences, Sichuan Provincial Laboratory for Natural Resources Protection and Sustainable Utilization, Chengdu, China MacroGenics Inc., 9640 Medical Center Drive, Rockville, MD 20850, USA. 3Department of Otolaryngology-Head and Neck Surgery, University of California, San Francisco, San Francisco, California. Department of Anesthesiology and Perioperative Medicine, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Science and Technology Town Hospital, No. 1 Lijiang Road, Suzhou 215153, China Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania Department of Neurobiology, School of Medicine, Kangwon National University, Chuncheon, Republic of Korea. Materials Characterization & Preparation Center; Southern University of Science and Technology; Shenzhen 518055; China College of Chemistry, Chemical Engineering and Materials Science, Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou 215123, People’s Republic of China; State Key Laboratory of Treatments and Recycling for Organic Effluents by Adsorption in Petroleum and Chemical Industry, Suzhou 215123, People’s Republich of China State Key Laboratory of Microbial Metabolism, School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, Shanghai, China School of Biomedical Engineering, Shenzhen University , Shenzhen, China 905249388@qq.com , xyzhang9@szu.edu.cn Department of Molecular Genetics and Microbiology, University of Florida, Gainesville, FL, USA National Key Laboratory of Veterinary Public Health and Safety, Key Laboratory of Animal Epidemiology of the Ministry of Agriculture and Rural Affairs, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China Department of Obstetrics and Gynecology Third Hospital, Peking University Beijing China Unit of Innate Immunity, Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China; College of Life Science, Shandong Normal University, Jinan, Shandong, China Orthopedics Department, First Affiliated Hospital of Kunming Medical University, Kunming 650032, Yunnan Province, China Department of Oncology, The Affiliated Hospital of Binzhou Medical University, Binzhou, Shandong 256603, China Department of Gastroenterology, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian Province, China Department of Ophthalmology, Yongchuan Hospital, Chongqing Medical University, Chongqing, China Department of Ophthalmology, West China Hospital of Sichuan University, Sichuan - PR China; Yongchuan Hospital, Chongqing Medical University, Chongqing - PR China College of Enology, Northwest A&F University, Xianyang 712100, China; China Wine Industry Technology Institute, Yinchuan 750021, China State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen 361102, Fujian, China Beijing Institute of Pharmacology and Toxicology, Beijing, China Department of Pharmacology and Toxicology, Dartmouth Medical School, Hanover, New Hampshire, USA Department of Echocardiography, Traditional Chinese Medical Hospital of Xinjiang Uygur Autonomous Region Department of Oral and Maxillofacial Surgery, School of Stomatology, Ninth People's Hospital School of Medicine, Shanghai Jiao Tong University, Shanghai 200011, China. lh3009100@sina.com Department of Parasitology, Southern Medical University, Guangzhou 510515, China. Guangdong Provincial Key Laboratory of Animal Molecular Design and Precise Breeding, Key Laboratory of Animal Molecular Design and Precise Breeding of Guangdong Higher Education Institutes, School of Life Science and Engineering, Foshan University, Foshan, China Department of Chemistry, Beijing Normal University, 19# Street Xinjiekou, Beijing, China, 100875 Institute of Computing Technology Chinese Academy of Sciences Beijing China Department of Emergency, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China Department of Obstetrics and Gynecology, Nagoya Graduate University School of Medicine; Department of Neurology, Yanbian University Hospital Collaborative Innovation Center of Suzhou Nano Science and Technology College of Chemistry Chemical Engineering and Materials Science Soochow University 199 Ren'ai Road Suzhou 215123 P. R. China Department of Diagnostic and Therapeutic Ultrasonography, Tianjin Medical University Cancer Institute and Hospital , Tianjin 300060 , China Department of Biological Science, Sookmyung Women’s University, Seoul 140-742, Republic of Korea.; College of Pharmacy, Sookmyung Women’s University, Seoul 140-742, Republic of Korea.; College of Pharmacy, Chungbuk National University, Cheungju 361-763, Republic of Korea. From Lillie Frank Abercrombie Section of Cardiology, Department of Pediatrics (H.L, Q.C., V.G., S.W.D., Q.W., J.A.T.), and Department of Molecular and Human Genetics (J.A.T.), Baylor College of Medicine, Houston, Tex; Children’s Hospital and Health Center, San Diego, Calif (J.C.P.); Department of Medicine, University of Rochester Medical Center, Rochester, NY (A.J.M., J.R.); Department of Medicine, LDS Hospital and University of Utah School of Medicine, Salt Lake City (G.M.V.); Department of... Department of Orthopedics the First Affiliated Hospital of Kunming Medical University Kunming China The Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College Kunming Yunnan China Department of Pathology Affiliated Hospital of Yanbian University Jilin China; Division of GI and Hepatology, Departments of Internal Medicine, The Research Institute of Clinical Medicine Chonbuk National University Medical School and Hospital Jeonju Jeonbuk Republic of Korea 5th Department of Gynecological Surgery, Affiliated Tumor Hospital of Xinjiang Medical University, Ürümqi, Xinjiang Uyghur Autonomous Region, China Liver Transplantation Center, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China. lihua100@yeah.net 2Department of Gynecologic Oncology, Cancer Institute and Hospital Department of Otolaryngology Head and Neck Surgery, University of California at San Francisco, San Francisco, California, USA Department of Nephrology Wuhan Fourth Hospital Puai Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan P.R. China Institute of Environment, Resource, Soil and Fertilizer, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, China Department of Chemistry, Nanchang University, Nanchang 330031, China. School of Life Sciences, Institute of Microbial Engineering Henan University Kaifeng China Key Laboratory for Magnetism and Magnetic Materials of the Ministry of Education; Lanzhou University; Lanzhou; People's Republic of China Department of General Surgery Zhenjiang First People’s Hospital, Medical School of Jiangsu University Zhenjiang Jiangsu China The Fishery Institute of The Sichuan Academy of Agricultural Sciences, Sichuan Provincial Laboratory for Natural Resources Protection and Sustainable Utilization, Chengdu, People’s Republic of China Key Laboratory of Terahertz Solid State Technology Shanghai Institute of Microsystem and Information Technology Chinese Academy of Sciences Shanghai 200050 China Southern Medical University, Guangzhou, People's Republic of China Key Laboratory of Plant Resources, Institute of Botany, Chinese Academy of Sciences, Beijing 100093, China; and; University of Chinese Academy of Sciences, Beijing 100049, China Institute of Structural Pharmacology & TCM Chemical Biology, College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China; Wuya College of Innovation, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China School of Environment Science and Resources, Shanxi University, Taiyuan 030031, China; Shanxi Laboratory for Yellow River, Taiyuan 030031, China Shanghai Institute of Cardiovascular Diseases Zhongshan Hospital Fudan University Shanghai China; Department of Physiology and Medicine/Cardiology University of California Los Angeles CA USA From the Departments of Medicine, Cardiovascular Sciences (Z.Y., J.A.T.) and General Medicine (G.D., B.C.), Pediatrics (Cardiology) (N.E.B., M.D.T., S.G., V.V.N., L.I.B., H.L., J.A.T.), Molecular and Human Genetics (S.E.S., J.A.T.), and Pathology (D.L.K.), Baylor College of Medicine, Houston, Tex; the Departments of Pathology and Dermatology (L.M.G., K.J.G.), Northwestern University Feinberg School of Medicine, Chicago, Ill; the Department of Pathology (J.E.S.), Beth Israel Deaconess Medical Center,... f School of Materials Science and Engineering, Tianjin Key Laboratory of Composite and Functional Materials, Tianjin University, Tianjin 300072, P. R. China Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, College of Chemistry & Materials Science, Northwest University, Xi’an, Shaanxi 710069, P. R. China Key Lab. of Non‐point Source Pollution Control Ministry of Agriculture the People's Republic of China; Institute of Environmental Science and Technology, Zhejiang Univ. HangZhou 310029 China MacroGenics Inc, Rockville, MD Shanghai Institute of Cardiovascular Diseases of Zhongshan Hospital Fudan University Shanghai China; Institute of Biomedical Science Fudan University Shanghai China Department of Plant and Soil Sciences, University of Kentucky, Lexington, KY 40546-0312, USA; and Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing 100850, China. Nephrology Department, Shaoyifu Hospital, Zhejiang Medical University, Hangzhou, China Division of Molecular Science, The Graduate School of Science and Technology, and Department of Chemistry, Faculty of Science, Kobe University, 1-1 Rokkodai-cho, Nada-ku, Kobe 657, Japan School of Cyberspace Security (School of Cryptology), Hainan University, Haikou 570228, China The First Affiliated Hospital of Chongqing Medical University Chongqing Key Laboratory of Ophthalmology and Chongqing Eye Institute, Chongqing, People's Republic of China Faculty of Informatics and Engineering The University of Electro‐Communications 1‐5‐1 Chofugaoka Chofu Tokyo 182–8585 Japan College of Pharmacy Sookmyung Women's University 52 Hyochangwon‐Gil, Yongsan‐Gu Seoul 140‐742 Korea Collaborative Innovation Center of Suzhou Nano Science and Technology College of Chemistry, Chemical Engineering and Materials ScienceSoochow University 199 Ren'ai Road Suzhou 215123 P.R. China Department of Rheumatology and Clinical Immunology, the Affiliated Hospital of Qingdao University, Qingdao, China Huazhong University of Science and Technology State Key Laboratory of Advanced Electromagnetic Engineering and Technology, , Wuhan, Hubei 430074, People's Republic of China Department of Cardiac Surgery; Zhongshan Hospital; Fudan University; Shanghai 200032; China Department of Orthopaedics Chinese PLA General Hospital Beijing China; National Clinical Research Center for Orthopaedics Sports Medicine & Rehabilitaion Beijing China First Hospital, Zhengzhou University, Zhengzhou 450052. Department of Bone and Joint Surgery and Sports Medicine Center, The First Affiliated Hospital, Jinan University, Guangzhou, People’s Republic of China College of Architecture and Environment, Sichuan University, Chengdu 610065, China. lh-506@163.com Tianjin Eye Hospital, Tianjin Eye Institute, Tianjin Key Lab of Ophthalmology and Visual Science, Tianjin Medical University and Nankai University, Tianjin 300020, China Plant Biotechnology Research Group (Virology), Western Australian State Agricultural Biotechnology Centre, Murdoch University, Murdoch 6150, Australia Army Engineering University of PLA-Shijiazhuang Campus, Shijiazhuang, Hebei 050003, P. R. China Department of Endocrinology and Metabolism The Affiliated Hospital of Southwest Medical University Luzhou Sichuan China College of Life Science and Engineering, Foshan University, Foshan, China Department of Clinical Laboratory Jiangbin Hospital of Guangxi Zhuang Autonomous Region Nanning Guangxi China Department of Gastroenterology, Cheeloo Children's Hospital, Shandong University, Jinan, Shandong 250022, China Department of Cardiology, Beijing Tongren Hospital, Beijing, China State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-Products, Institute of Environment, Resource, Soil and Fertilizer, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, China Department of Pediatrics, Affiliated Renhe Hospital of China Three Gorges University, Second Clinical Medical College of China Three Gorges University, Yichang, China Department of General Surgery, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710004, P.R. China Department of Immunology, Graduate School of Medicine, Kagoshima University, Kagoshima, Japan The Institute of Medical Biology, Chinese Academic Medical Sciences & Peking Union Medical College, Kunming, China School of Software Engineering, Huazhong University of Science and Technology, Wuhan 430074, Hubei, China Institute of Imaging Science; Vanderbilt University; Nashville Tennessee USA; Department of Radiology and Radiological Sciences; Vanderbilt University; Nashville Tennessee USA Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai China Department of Traditional Chinese Medicine; Guangdong Institute for Food and Drug Control; Guangzhou P.R. China Biotherapeutics Disccovery Research, Boehringer Ingelheim Pharmaceuticals, Inc, Ridgefield, CT, USA State Key Laboratory of Molecular Biology, Chinese Academy Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China;; National Center for Protein Science Shanghai, Shanghai Science Research Center, Chinese Academy of Sciences, Shanghai 200031, China; The State Key Laboratory of Remote Sensing Science; Institute of Remote Sensing and Digital Earth; Chinese Academy of Sciences; Beijing; China Institute of Epidemiology and Preventive Medicine College of Public Health National Taiwan University Taipei Taiwan Collaborative Innovation Center of Suzhou Nano Science and Technology College of Chemistry Chemical Engineering and Materials Science Soochow University 199 Ren'ai Road Suzhou 215123 P.R. China Department of Laboratory Medicine, The First Affiliated Hospital of China Medical University, Shenyang, China. Department of Anesthesiology Shanghai Pulmonary Hospital, Tongji University School of Medicine Shanghai China Authors' Affiliations: Departments of 1Pharmacology and Toxicology, 2Biochemistry, 3Pathology, 4Medicine, and 5Norris Cotton Cancer Center, Dartmouth Medical School, Hanover, New Hampshire and Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire; 6Center for Molecular Therapeutics, Massachusetts General Hospital Cancer Center, Charlestown, Massachusetts; and 7Cyclacel Ltd., Dundee, United Kingdom College of Pharmacy Dalian Medical University Western 9 Lvshun South Road Dalian 116044 China Institute of Imaging Science Vanderbilt University Nashville TN USA; Department of Physics and Astronomy Vanderbilt University Nashville TN USA Department of Cardiac Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China Department of Geriatric Endocrinology; The First Affiliated Hospital of Zhengzhou University; Zhengzhou; China Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China; Institutes of Biomedical Sciences, Fudan University, Shanghai, China Key Laboratory of Structure-Based Drug Design & Discovery, School of Traditional Chinese Materia Medica, Ministry of Education, Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, People’s Republic of China; Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of China College of Chemistry Chemical Engineering and Materials Science Collaborative Innovation Center of Suzhou Nano Science and Technology Soochow University Suzhou Jiangsu 215123 China; National Center of International Research on Intelligent New Nanomaterials and Detection Technologies in Environmental Protection Suzhou Jiangsu 215123 China State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Shandong Eye Institute, Shandong First Medical University & Shandong Academy of Medical Sciences, Qingdao, China Institute of Clinical Medicine Research, The Affiliated Suzhou Science and Technology Town Hospital of Nanjing Medical University, Suzhou, Jiangsu 215153, P.R. China State Key Laboratory of Molecular Biology, Shanghai Science Research Center, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China. Electronic address: lihua@sibcb.ac.cn. Wistar Institute, Philadelphia, PA 19104. Department of Molecular Science, Graduate School of Science and Technology, Kobe University, 1-1, Rokkodai-cho, Nada-ku, Kobe 657-8501, Japan; Department of Molecular Physiology and Biophysics, Faculty of Medicine, University of Fukui, Yoshida, Fukui 910-1193, Japan; Department of Biotechnological Science, School of Biology-Oriented Science and Technology, Kinki University, 930 Nishimitani, Uchita-cho, Wakayama 649-6493, Japan; and Department of Biology, Faculty of Science, Kobe University, 1-1,... Department of Plastic and Reconstructive Surgery, Sir Run Run Shaw Institution of Clinic Medicine, Zhejiang University, Hangzhou, China. 15Department of Oncology, Chengdu Military General Hospital, Chengdu, Sichuan, P.R. China. Department of Neurology, Xi'an Children's Hospital Xi'an 710003, China. Wuya College of Innovation, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China | Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China Department of Public Health Sciences, University of Miami Miller School of Medicine, Miami, Florida Jiangxi Province Key Laboratory of Laboratory Medicine, Department of Laboratory Medicine, Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China (mainland) Henan Joint International Research Laboratory of Veterinary Biologics Research and Application, Anyang Institute of Technology, Anyang, Henan 455000, P.R. China; Key Laboratory of Pesticide and Chemical Biology of the Ministry of Education, International Joint Research Center for Intelligent Biosensor Technology and Health, College of Chemistry, Chemical Biology Center, Central China Normal University, Wuhan, Hubei 430079, P.R. China Department of Pediatrics, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong 510630, P.R. China Department of Bioengineering University of Illinois at Urbana‐Champaign Urbana Illinois USA; Carle Foundation Hospital Urbana Illinois USA; Cancer Center at Illinois Urbana Illinois USA Department of Biochemistry and Molecular Biology, College of Basic Medicine, Jinzhou Medical University, Jinzhou, Liaoning 121000, P.R. China Department of Oral and Maxillofacial Surgery Beijing Stomatological Hospital, Capital Medical University Beijing 100050 China Animal Nutrition Institute; Sichuan Agricultural University; Key Laboratory for Animal Disease-Resistance Nutrition of Ministry of Education of China; Key Laboratory for Animal Disease-Resistance Nutrition and Feed of Ministry of Agriculture of China; Key laboratory of Animal Disease-resistant Nutrition of Sichuan Province Department of Neurology, The 476th Hospital of The People’s Liberation Army, Fuzhou, China Departments of aOtolaryngology, Guangdong Provincial Key Laboratory of Animal Molecular Design and Precise Breeding, School of Life Science and Engineering, Foshan University, Foshan, 528231 Guangdong, China Department of Chemistry and Chemical Engineering, Hunan Institute of Science and Technology, Yueyang 414006, China School of Pharmacy and Medical Sciences, Sansom Institute, University of South Australia, Adelaide, SA 5000, Australia School of Molecular Sciences, University of Western Australia, Crawley, Western Australia 6009, Australia Department of Gastrointestinal Oncology, Xingtai People’s Hospital, Xingtai, China Department of Pediatrics, Hezhou City People’s Hospital, Hezhou, China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of Sciences Beijing 100049 China; Key Laboratory of Terahertz Solid State Technology Shanghai Institute of Microsystem and Information Technology Chinese Academy of Sciences Shanghai 200050 China Plant Biotechnology Research Group – Virology, Western Australian State Agricultural Biotechnology Centre, School of Veterinary and Life Sciences, Murdoch University, Perth, WA, Australia Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education; College of Chemistry & Materials Science; Northwest University; Xi'an 710069; P. R. China Department of Nephrology, Wuhan Fourth Hospital, Puai Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei China Department of Orthopedics Harrison International Peace Hospital The People's Hospital of Hengshui City Hengshui China Department of Obstetrics and Gynecology, Fujian Provincial Maternity and Children’s Hospital, Affiliated Hospital of Fujian Medical University, Fuzhou Fujian, China Department of Paediatrics The First Affiliated Hospital of Jinan University Guangzhou China Department of Neurology, Zhuhai Hospital of Integrated Traditional Chinese and Western Medicine, Zhuhai, China State Key Laboratory of Toxicology and Medical Countermeasures; Beijing; China; Beijing Institute of Pharmacology and Toxicology; Beijing Department of Computational Medicine and Bioinformatics, University of Michigan. Wuya College of Innovation, Key Laboratory of Structure‑Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, P.R. China Department of Radiation Oncology; Washington University School of Medicine; 4921 Parkview Place St. Louis MO 63110 USA Clinical College of Ophthalmology, Tianjin Medical University, Tianjin 300020, China; Tianjin Eye Hospital, Tianjin 300020, China; Tianjin Key Laboratory of Ophthalmology and Visual Science, Tianjin 300020, China; Tianjin Eye Institute, Tianjin 300020, China Department of General Surgery Second Affiliated Hospital Xi'an Jiaotong University School of Medicine Xi'an China College of Chemistry, Chemical Engineering and Materials Science, Collaborative Innovation Center of Suzhou Nano Science and Technology Institution Soochow University Suzhou 215123 P. R. China Institute of High Performance Computing, National University of Singapore, 1 Science Park Road, #01-01 The Capricorn, Singapore Science Park II, Singapore 117528, and School of Mechanical and Production Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798 College of Enology, Northwest A&F University, Yangling, China; China Wine Industry Technology Institute, Yinchuan, China; Shaanxi Engineering Research Center for Viti-Viniculture, Yangling, China Key Laboratory of Pesticide & Chemical Biology of Ministry of Education, International Joint Research Center for Intelligent Biosensor Technology and Health of Ministry of Science and Technology, Central China Normal University, Wuhan 430079, People’s Republic of China Institute of Chinese Materia Medica, China Academy of Traditional Chinese Medicine, Beijing, 100700 China. The First College of Clinical Medical Science, China Three Gorges University/Yichang Central People's Hospital, Yichang, Hubei 443000, P.R. China Department of Gastroenterology, The First Affiliated Hospital, School of Medicine, Xiamen University , Xiamen , China; The School of Clinical Medicine, Fujian Medical University , Fuzhou , China School of Software Engineering, Huazhong University of Science and Technology, Wuhan, China; Department of AIDS Prevention and Control, Shaanxi Provincial Center for Disease Prevention and Control, Xi'an, China. Department of Ultrasonography Yantai Affiliated Hospital of Binzhou Medical University Yantai People's Republic of China Department of Gynecologic Oncology, Cancer Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100021, China. The Second Affiliated Hospital; Nanchang University; Nanchang 330006; China Central Research Institute, Shanghai Pharmaceutical Holding Co., Ltd., Building 5, 898 Ha Lei Road, Zhangjiang Hi-Tech Park, Shanghai 201203, China State Key Laboratory of Plant Genomics Institute of Genetics and Developmental Biology Chinese Academy of Sciences Beijing 100101 China; National Center for Plant Gene Research (Beijing) Institute of Genetics and Developmental Biology Chinese Academy of Sciences Beijing 100101 China Department of Nephrology and Rheumatology, Puai Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China Wuya College of Innovation, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China; Institute of Structural Pharmacology & TCM Chemical Biology, College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China Department of Cardiovascular Surgery Maoming People's Hospital Maoming China Nanyang Technological University School of Mechanical and Aerospace Engineering, , 50 Nanyang Avenue, Singapore 639798 Department of Pathobiology, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA Department of Medical Oncology, The Fourth Affiliated Hospital of Guangxi Medical University, Liuzhou, Guangxi, China Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, P. R. China Boehringer Ingelheim Pharmaceuticals, 900 Ridgebury Road, Ridgefield, CT 06877, USA Department of Oncology, Hebei Chest Hospital, Research Center of Hebei Lung Cancer Prevention and Treatment, Shijiazhuang, Hebei 050041, P.R. China College of Food Science and Engineering, Shanxi Agricultural University, Jinzhong 030801, China Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai Key Laboratory of Applied Surface and Colloid Chemistry Ministry of Education, School of Chemistry and Chemical Engineering Shaanxi Normal University Xi'an 710119 P.R. China Sir Run Run Shaw Hospital Zhejiang University School of Medicine Hangzhou China Department of Rheumatology and Immunology, The Affiliated Hospital of Qingdao University, Qingdao 266555, China. Key Laboratory of Mariculture and Stock Enhancement in North China’s Sea, Ministry of Agriculture, Dalian Ocean University, Dalian 116023, China Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China; Graduate University of Chinese Academy of Sciences, Beijing 100049, China Changchun University of Science and Technology, School of Compute Science and Technology, Changchun, Jilin 130022, China Department of Food Science and Nutrition, Zhejiang University, 268 Kaixuan Road, Hangzhou, Zhejiang, China 310029. Department of Surgical Oncology, Xingtai People’s Hospital, Hebei Medical University , Xingtai, Hebei, P. R. China Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan 48109 Department of Plastic Surgery, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, People’s Republic of China Liver Transplantation Center, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510630, China. Department of Human Anatomy, School of Preclinical and Forensic Medicine, Sichuan University, Chengdu 610041, China. Tianjin Eye Hospital, Tianjin Key Lab of Ophthalmology and Visual Science, Tianjin Eye Institute, Clinical College of Ophthalmology Tianjin Medical University, Tianjin, China; Tianjin Eye Hospital, Nankai University Affiliated Eye Hospital, Tianjin, China Department of Anatomy, Chungbuk National University Medical School, Cheongju, Korea. School of Mechanical and Aerospace Engineering Nanyang Technological University Singapore Singapore Department of Pediatrics, The First Affiliated Hospital, Jinan University, Guangzhou 510630, China. songyuanzong@vip.tom.com. Wuya College of Innovation, Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education Shenyang Pharmaceutical University Shenyang 110016 P. R. China; Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 P. R. China Department of Burns & Plastic Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, PR China Public Health Sciences, Division of Biostatistics, University of Miami Leonard Miller School of Medicine, Miami, FL Department of Cardiology People's Liberation Army No. 105 Hospital Hefei Anhui China Katzin Diagnostic & Research PET/MRI Center, Nemours/Alfred I. duPont Hospital for Children, Wilmington, DE Department of General Toxicology National Shanghai Center for New Drug Safety Evaluation and Research Shanghai 201203 China Department of Plant Pathology, University of Kentucky, 1405 Veteran’s Dr., Lexington, KY 40546 Institute of Imaging Science, Vanderbilt University Nashville Tennessee USA; Department of Physics and Astronomy Vanderbilt University Nashville Tennessee USA Clinical College of Ophthalmology, Tianjin Medical University, Tianjin 300020, P.R. China Division of Biostatistics Department of Epidemiology and Public Health University of Miami Miller School of Medicine Miami FL Department of Biomedical Engineering, School of Engineering, China Pharmaceutical University, 24 Tongjia Lane, Gulou District, Nanjing 210009, China Department of Chemistry and Chemical Engineering; Hunan Institute of Science and Technology; Yueyang 414006; China Department of Epilepsy center, Guangdong 999 Brain Hospital, Guangzhou, China. 1Department of Otolaryngology – Head and Neck Surgery, University of California San Francisco, San Francisco, California. Key Laboratory of Marine Materials and Related Technologies, Zhejiang Key Laboratory of Marine Materials and Protective Technologies, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences 1 , Ningbo 315201, China State Key Laboratory of Applied Organic Chemistry, Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, Lanzhou University, Gansu, Lanzhou 730000, China Department of Cardiology, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Xueyuanxi Road, No. 109, Wenzhou, Zhejiang 325000, China Department of Pathology, Hua Bei Oil Field Total Hospital Hebei, People's Republic of China. Nanoelectronics Laboratory, Department of Electrical Engineering and Computing Systems, University of Cincinnati 1 , Cincinnati, Ohio 45221, USA Center for Mitochondrial Biology and Medicine, The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi’an Jiaotong University, Xi’an 710049, China The Key Laboratory of Cellular and Molecular Evolution, Kunming Institute of Zoology, the Chinese Academy of Sciences, Kunming, Yunan 650 223, China. okhua@yahoo.com.cn Guangdong Provincial Key Laboratory of Animal Molecular Design and Precise Breeding, School of Life Science and Engineering Foshan University Foshan China; Guangdong Tinoo’s Foods Co., Ltd Qingyuan Guangdong China School of Molecular Sciences, The University of Western Australia, Crawley, Perth 6009, Australia Department of Oncology, The General Hospital of Western Theater Command, Chengdu, Sichuan 610083, P.R. China Beijing Institute of Pharmacology and Toxicology, Beijing, China; State Key Laboratory of Toxicology and Medical Countermeasures, Beijing, China Department of Physiology and BiophysicsAlbert Einstein College of MedicineBronxNew YorkUSA College of Chemistry, Chemical Engineering and Materials Science, Collaborative Innovation Center of Suzhou Nano Science and Technology, National United Engineering Laboratory of Functionalized Environmental Adsorption Materials, Soochow University, Suzhou 215123, People’s Republic of China School of Plant Biology, The University of Western Australia, Crawley, W.A. 6009, Australia College of Enology, Northwest A&F University, Xianyang 712100, China; China Wine Industry Technology Institute, Yinchuan 750021, China; Shaanxi Engineering Research Center for Viti-Viniculture, Xianyang 712100, China; Engineering Research Center for Viti-Viniculture, National Forestry and Grassland Administration, Xianyang 712100, China Institute of Imaging Science Vanderbilt University Medical Center Nashville Tennessee; Department of Radiology and Radiological Sciences Vanderbilt University Medical Center Nashville Tennessee State Key Laboratory of Fine Chemicals; DUT-KTH Joint Education and Research Center on Molecular Devices; Dalian University of Technology (DUT); 116024 Dalian; P. R. China College of Agronomy, Anhui Agricultural University, Hefei 230036, China Graduate School of Science and Technology, Kobe University, 1-1 Rokkodai-cho, Nada-ku, Kobe 657-8501, Japan Department of Anatomy and Neurobiology, Institute of Neurodegeneration and Neuroregeneration, College of Medicine, Hallym University, Chuncheon, Republic of Korea Stowers Institute for Medical Research, Kansas City, MO 64110, USA. Materials Characterization & Preparation Center South University of Science and Technology of China Shenzhen 518055 China College of Geography and Environmental Science; College of Chemistry and Life Science; Zhejiang Normal University; Jinhua 321004, China From the Lindsley F. Kimball Research Institute of The New York Blood Center, New York. Clinical College of Ophthalmology, Tianjin Medical University, Tianjin, China Key Laboratory of Applied Surface and Colloid Chemistry Ministry of Education Key Laboratory for Advanced Energy Devices Shaanxi Engineering Lab for Advanced Energy Technology School of Materials Science and Engineering Shaanxi Normal University Xi'an 710119 China 1Department of Otolaryngology - Head and Neck Surgery, University of California San Francisco, San Francisco, California. Shanghai Institute of Cardiovascular Diseases of Zhongshan Hospital Fudan University Shanghai China College of Chemistry, Chemical Engineering, and Materials Science, Collaborative Innovation Center of Suzhou Nano Science and Technology, National Center for International Research, and ‡Institute of Functional Nano & Soft Materials Laboratory and Jiangsu Key Laboratory for Carbon-Based Functional Materials, Soochow University, Suzhou 215123, P. R. China Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, P.R. China; State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai, P.R. China College of Chemistry and Molecular Sciences Wuhan University Wuhan 430072 China Department of Oncology, The General Hospital of Western Theater CommandChengduP.R. China CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences (CAS), Beijing, PR China Urban Environmental Management Field of Study, Asian Institute of Technology, Pathumthani, Thailand Department of Cardiology, First Affiliated Hospital, China Medical University, Shenyang 110001, China. Department of Geriatric Medicine, Qingdao University Affiliated Yantai Yuhuangding Hospital Qingdao, China. SUSTech Core Research Facilities, Southern University of Science and Technology, Shenzhen 518055, China; State Key Laboratory of Environmental and Biological Analysis, Department of Chemistry, Hong Kong Baptist University, Hong Kong SAR, China Key Laboratory of Laboratory Medicine in Jiangxi Province, Department of the Clinical Laboratory, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China; Southern Center for Biomedical Research and Fujian Key Laboratory of Developmental and Neural Biology, College of Life Sciences, Fujian Normal University, Fuzhou, Fujian Province 350108, P.R. China; Department of Cell and Molecular Biology, Tulane University, New Orleans, LA 70118, USA Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China the Departments of Pediatrics (R.O.-L., H.L., J.S., V.G., J.A.T.) and Molecular and Human Genetics (J.A.T.), Baylor College of Medicine, Houston, Tex. College of Life and Environmental Sciences & Beijing Engineering Research Center of Food Environment and Public Health; Minzu University of China; Beijing 100081; P. R. China State Key Laboratory of Metal Matrix Composites School of Materials Science and Engineering Shanghai Jiao Tong University Shanghai 200240 PR China Department of Orthopedics The Second Affiliated Hospital of Xuzhou Medical University Xuzhou China MacroGenics, Inc., Rockville, Maryland 20850 Department of Biochemistry and Molecular Biology, Medical Experimental Teaching Center, Nanchang University, Nanchang, Jiangxi, China (mainland) Department of Parasitology, School of Public Health and Tropical Medicine, Southern Medical University, Guangzhou 510515, China. Key Laboratory of Structure-Based Drug Design & Discovery, Wuya College of Innovation, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China; Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China Department of Endoscopic Diagnosis and Therapy, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy of Tianjin, Tianjin Clinical Research Center for Cancer, Tianjin 300060, P.R. China Department of Ophthalmology, Yongchuan Hospital of Chongqing Medical University, Chongqing, China Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Institute of Animal Nutrition, Sichuan Agricultural University, Chengdu, Sichuan, People’s Republic of China Institute of Imaging Science, Vanderbilt University; Nashville Tennessee USA; Department of Physics and Astronomy; Vanderbilt University; Nashville Tennessee USA College of Enology, Northwest A&F University, Yangling, Shaanxi, PR China; Shaanxi Engineering Research Center for Viti-Viniculture, Yangling, Shaanxi, PR China; China Wine Industry Technology Institute, Zhongguancun innovation Center, Yinchuan, Ningxia, PR China Department of Ophthalmology, No.2 People’s Hospital of Yunnan Province, Kunming, China Fifth Department of Surgery, Penglai People's Hospital Yantai 265600, Shandong, China. Department of Oral and Maxillofacial‐Head and Neck Oncology Beijing Stomatological Hospital, Capital Medical University Beijing China State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, People’s Republic of China Department of Endoscopy Tianjin Medical University Cancer Institute and Hospital National Clinical Research Center for Cancer Key Laboratory of Cancer Prevention and Therapy of Tianjin Tianjin's Clinical Research Center for Cancer Tianjin People's Republic of China Institute of Animal Nutrition Sichuan Agricultural University Chengdu China State Key Laboratory of Applied Organic Chemistry; Laboratory of Special Function Materials and Structure Design of the Ministry of Education; College of Chemistry and Chemical Engineering; Lanzhou University; Lanzhou 730000 State Key Laboratory of Metal Matrix Composites, School of Materials Science and Engineering, Shanghai Jiaotong University, Shanghai 200240, People’s Republic of China School of Light Industry, Beijing Technology and Business University, Beijing 100048, China Department of Neurology Guangdong 999 Brain Hospital Guangzhou China; China Paroxysmal Dyskinesia Collaborative Group (CPDCG) Shanghai China From the Department of Neurology (J.W., F.L., L.X., W.S., M.L., D.L., Y.J., R.G., H.L., W.Z., G.X., X.L.), Jinling Hospital, Medical School of Nanjing University, Nanjing; Department of Neurology (F.P.), Jinling Hospital, Nanjing Medical University, Nanjing; Department of Neurology (F.P.), Zhongshan Hospital Xiamen University, Xiamen; Department of Neurology (D.L.), the First People's Hospital Affiliated to Shanghai Jiao Tong University, Shanghai; and Department of Neurology (Y.J.), the Second... Authors' Affiliations: 1MacroGenics, Inc., South San Francisco, California and 2MacroGenics, Inc., Rockville, Maryland Research center for cell fate control, College of Pharmacy, Sookmyung Women’s University, Seoul, Republic of Korea Key Laboratory of Plant Resources, Institute of Botany, The Innovative Academy of Seed Design, Chinese Academy of Sciences, Beijing, China; University of Chinese Academy of Sciences, Beijing, China Department of Basic Medicine Huzhou University School of Medicine Huzhou Zhejiang China Institute of Imaging Science Vanderbilt University Nashville Tennessee USA; Department of Physics and Astronomy Vanderbilt University Nashville Tennessee USA Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine *Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai 200031, China;; †University of Chinese Academy of Sciences, Beijing 100039, China; and; ‡College of Life Science, Shandong Normal University, Jinan 250014, China Department of Obstetrics and Gynecology, University of Wisconsin–Madison, Madison, Wisconsin 53715; Department of Rheumatology and Immunology, the Affiliated Hospital of Qingdao University, Qingdao 266000, Shandong, China College of Chemistry, Chemical Engineering and Materials Science Collaborative Innovation Center of Suzhou Nano Science and Technology Soochow University 199 Ren'ai Road, Sushou Jiangsu P.R. China School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, PR China; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, Liaoning, 110016, PR China Department of Plastic Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China Department of Public Health SciencesUniversity of Miami Leonard M. Miller School of MedicineMiami Florida Key Laboratory of Computational Intelligence and Chinese Information Processing of Ministry of Education, Shanxi University, Taiyuan, Shanxi 030006, China; Department of Mathematics and Physics, Shijiazhuang Tiedao University, Shijiazhuang, Hebei 050043, China Stowers Institute for Medical Research, Kansas City, MO 64110 Biotherapeutics Discovery, Boehringer Ingelheim Pharmaceuticals, Inc., 900 Ridgebury Road, Ridgefield CT 06877, USA Stowers Institute for Medical Research, Kansas City, MO, USA State Key Laboratory of Plant Physiology and Biochemistry China Agricultural University Beijing China; National Center for Evaluation of Agricultural Wild Plants (Rice) Beijing Key Laboratory of Crop Genetic Improvement Laboratory of Crop Heterosis and Utilization MOE Department of Plant Genetics and Breeding China Agricultural University Beijing China West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Chengdu, Sichuan 610041, P.R. China Department of Orthopedics, Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Luzhou, Sichuan Province, China. Department of Biochemistry and Molecular Biology, College of Basic Medicine, Jinzhou Medical University, Jinzhou, Liaoning Province, PR China Department of Plant Pathology, University of Kentucky, Lexington, KY 40546 Department of Radiation Oncology Washington University in St. Louis School of Medicine St. Louis Missouri USA Centre for Advanced Particle Processing and Transport, The University of Newcastle, Callaghan, New South Wales 2308, Australia Department of Rehabilitation, Shenzhen Second People’s Hospital, The First Affiliated Hospital, Shenzhen University School of Medicine, Shenzhen, China Department of Nephrology Zhejiang University Medical College Affiliated Sir Run Run Shaw Hospital Qingchun Road 3rd Hangzhou 310016 Zhejiang Province China Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China Department of Ophthalmology, Qilu Medical College of Shandong University, Jinan 250012, Shandong Province, China. Qingdao Eye Hospital, State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Shandong Eye Institute, Shandong First Medical University&Shandong Academy of Medical Sciences, Qingdao 266071, Shandong Province, China. School of Biomedical Engineering, Bio-ID Research Center, State Key Laboratory for Oncogenes and Related Genes, Shanghai Jiao Tong University, Shanghai, China Department of Chemistry; Collaborative Innovation Center of Chemical Science and Engineering; Tianjin University; Tianjin 300072; P. R. China Department of Orthopaedic Surgery Shanghai Key Laboratory of Orthopaedic Implants Shanghai Ninth People's Hospital Shanghai JiaoTong University School of Medicine Shanghai China College of Life Science, Foshan University, Foshan, Guangdong 528231, China Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China; Wuya College of Innovation, School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China School of Life Sciences, Henan University, Kaifeng 475004, China; Engineering Research Center for Applied Microbiology of Henan Province, Kaifeng 475004, China Department of Anesthesiology, Affiliated Hospital of Yunnan University, Kunming, PR China. College of Enology, Northwest A&F University, Xianyang 712100, China; China Wine Industry Technology Institute, Yinchuan 750021, China; Shaanxi Engineering Research Center for Viti-Viniculture, Xianyang 712100, China College of Chemistry Chemical Engineering and Materials Science Soochow University Suzhou Jiangsu 215123 China School of Mechanical and Aerospace Engineering Nanyang Technological University Singapore 639798 Singapore Department of Neurology, the 476 Hospital of Chinese PLA, Fuzhou 350002, Fujian Province, China. School of Molecular Sciences; The University of Western Australia; Australia Stowers Institute for Medical Research Kansas City Missouri USA Fifth Department of Surgery, The People's Hospital of Penglai Yantai, Shandong Province, China. Wuya College of Innovation, School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China; Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, People's Republic of China Key Laboratory of Molecular Engineering of Polymer Ministry of Education Department of Macromolecular Science, Fudan University, 200433, Shanghai, China Department of Geriatric Endocrinology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, P. R. China Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430074, China Authors' Affiliations: 1Gene Expression and Regulation Program, The Wistar Institute; 2Histopathology Facility; 3Department of Pathology; 4Biostatistics and Bioinformatics Facility; 5Transgenic Facility; 6Women's Cancer Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania; 7Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts; 8Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, Alabama; and 9Human Genetics Programme, Spanish National Cancer Research Centre (CNIO) and Hospital Universitario Puerta de Hierro-Majadahonda, Madrid, Spain The Shanghai Institute of Hypertension Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China Department of Radiation Oncology Washington University St. Louis MO 63110 USA School of Earth and Geographical Sciences, Faculty of Natural and Agricultural Sciences, The University of Western Australia, Crawley, W.A. 6009, Australia Authors' Affiliations: 1Women's Cancer Program, 2Biosample Repository Facility, 3Department of Pathology, 4Transgenic Facility, 5Department of Bioinformatics and Biostatistics, and 6Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania; 7Massachusetts General Hospital Cancer Center, Boston, Massachusetts; and 8University of Kansas Medical Center, Kansas City, Kansas Institute of Pharmacology and Toxicology Beijing China Key Laboratory of Agro‐ecological Processes in Subtropical Region Institute of Subtropical Agriculture, Chinese Academy of Sciences Changsha China; University of Chinese Academy of Sciences Beijing China Guangdong Provincial Key Laboratory of Animal Molecular Design and Precise Breeding Foshan University Foshan China Department of Ophthalmology, Yongchuan Hospital, Chongqing Medical University National Shanghai Center for New Drug Safety Evaluation and Research Shanghai China Institute of Biomedical Science Fudan University Shanghai China College of Enology Northwest A & F University Yangling China; Shaanxi Engineering Research Center for Viti‐Viniculture Yangling China Department of Nephrology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China grid.258151.a 0000000107081323 The Key Laboratory of Industrial Biotechnology of Ministry of Education, National Engineering Laboratory for Cereal Fermentation Technology School of Biotechnology, Jiangnan University 1800 Lihu Road 214122 Wuxi Jiangsu People’s Republic of China Chengdu Qingbaijiang Maternal and Child Health Care Hospital, Chengdu, 610300 Sichuan, China Biotherapeutics Pharmacokinetics, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT, USA Biology Department, Brookhaven National Laboratory, Upton, NY 11973-5000; Experimental Teaching Center of Preventive Medicine, School of Public Health, Southern Medical University, Guangzhou, Guangdong, China Authors' Affiliations: 1First Department of Internal Medicine, Sapporo Medical University, Sapporo, Japan; Departments of 2Medicine and 3Cell Biology, Vanderbilt-Ingram Cancer Center and Vanderbilt University, Nashville, Tennessee; and 4The Institute of Medical Science, The University of Tokyo, Tokyo, Japan Institute for Infectious Diseases and Endemic Diseases Prevention and Control Beijing Tongzhou Center for Diseases Prevention and Control Beijing China Institute of Polymer Science and Engineering Hebei University of Technology Tianjin 300130 P. R. China From the Departments of Biotechnology (R.W., H.L, H. Wu) and Bioscience (Y.Q., X.W., X.Z.), School of Life Science, Jilin Normal University, Siping, China; Key Laboratory of Cardiovascular Medicine Research of Ministry of Education, Harbin Medical University, Harbin, China (R.W.); Department of Physiology, Zhejiang University School of Medicine, Hangzhou, China (Q.H., R.Z., H. Wang, E.Y.L.); Department of Cardiology, the First Affiliated Hospital, Harbin Medical University, Harbin, China (Z.D.);... College of Polymer Science and Engineering Sichuan University Chengdu 610065 China Hemodialysis Center Royal Adelaide Hospital Adelaide South Australia Australia Department of Pathology, Medical School, Fudan University, Shanghai 200032, China. Department of Biomedical Engineering, School of Engineering, China Pharmaceutical University, 639 Longmian Road, Jiangning District, Nanjing, 210009, China Department of General Surgery, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710004, China. Department of Ultrasound, the Third Hospital of Hebei Medical University, Shijiazhuang, P.R. China Department of Respiratory and Critical Care Medicine, Second Hospital of Tianjin Medical University, Tianjin 300211, China Department of Medical Genetics & the Prenatal Diagnosis Center of Hunan Province Hunan Provincial Maternal and Child Health Care Hospital Changsha Hunan China Key Laboratory of Stem Cell Engineering and Regenerative Medicine of Fujian Province University Fujian Medical University Fuzhou China; Department of Anatomy, Histology and Embryology School of Basic Medical Sciences Fujian Medical University Fuzhou China Department of Neurology Affiliated Hospital of Hebei University of Engineering Handan Hebei China Department of Stomatology, The First Medical Center of PLA General Hospital, Beijing, P.R. China 1Department of Pharmacology and Toxicology, Dartmouth Medical School, Hanover, New Hampshire; Department of Hepatic Surgery,The Third Affiliated Hospital of Sun Yat‐sen University,Guangzhou,China From the J. Philip Kistler Stroke Research Center, Department of Neurology (S.L., N.S.R., F.O.L., M.B.M., R.E.G., T.K.T., A.J.D.), Department of Radiology (H.L., G.J.H.), and Neuroprotection Research Laboratory, Neuroscience Center, Departments of Neurology and Radiology (K.A., A.T.S., L.-D.D.P., E.H.L.), Massachusetts General Hospital, Harvard Medical School, Boston; Department of Neurology, Rhode Island Hospital, Alpert Medical School of Brown University, Providence (M.K., K.L.F.); Athinoula A.... Center for Mitochondrial Biology and Medicine, the Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi’an Jiaotong University, Xi’an 710049, China State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, P. R. China Department of Cardiovascular Medicine, Centre for Epidemiological Studies and Clinical Trials, Shanghai Key Laboratory of Hypertension, The Shanghai Institute of Hypertension, Shanghai, China; Department of Hypertension, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China College of Information and Computer Taiyuan University of Technology Taiyuan 030600 China Department of Liver Surgery and Liver Transplantation, Guangzhou Clinical Research and Translation Center for Liver Disease, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China Laboratory animal center, The Second Affiliated Hospital Guangzhou Medical University Guangzhou China Ultrasound Department of Hepatology, First Hospital of Jilin University, 71 Xin Min Street, Changchun, Jilin Province 130021, China Department of Head & Neck-Plastic Surgery, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou 310016, China. Department of Clinical Laboratory of the Second Affiliated Hospital Nanchang University Nanchang China Division of Radiation and Cancer Biology, Department of Radiation Oncology, University of Michigan, Ann Arbor, MI 48109 Wuya College of Innovation Key Laboratory of Structure-Based Drug Design & Discovery Ministry of Education Shenyang Pharmaceutical University Shenyang 110016 China; Institute of Structural Pharmacology & TCM Chemical Biology, College of Pharmacy Fujian University of Traditional Chinese Medicine Fuzhou 350122 China Laboratory of Regenerative Biology, Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China Departments of Physics, School of Physics and Electronic Engineering, Harbin Normal University, Harbin, 150025, P. R. China Department of Plastic Surgery, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Department of Neurology, the 476th Hospital of the People’s Liberation Army Department of Gastroenterology, First Affiliated Hospital of Xiamen University, Fujian Province, China. Faculty of Informatics and Engineering, The University of Electro-Communications, 1-5-1 Chofugaoka, Chofu, Tokyo 182-8585, Japan College of Nursing University of Saskatchewan Saskatoon Canada *Chinese Academy of Sciences Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai 200031, China;; †College of Life Science, Shandong Normal University, Jinan 250014, China; Department of Microbiology, College of Life Science, Hunan Normal University, Changsha, Hunan 410081, China Authors' Affiliations: 1Division of Radiation and Cancer Biology, Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan; 2Department of Biochemistry, Molecular and Cellular Biology, Key Laboratory of the Education Ministry for Cell Differentiation and Apoptosis, Institutes of Medical Sciences, Shanghai Jiaotong University School of Medicine, Shanghai, PR China; and 3Division of Hematology/Oncology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan Department of Oral and Maxillofacial Surgery, Ninth People's Hospital, School of Stomatology, Shanghai, China. Vanderbilt University Institute of Imaging Science Vanderbilt University Nashville TN USA; Department of Radiology and Radiological Sciences Vanderbilt University Nashville TN USA Key Laboratory for Special Function Materials and Structural Design of the Ministry of Education School of Physical Science and Technology Lanzhou University Lanzhou 730000 China Affiliated Obstetrics and Gynecology Hospital of Fudan University, Shanghai 200011, China. Vanderbilt University Institute of Imaging Science Nashville Tennessee; Department of Radiology and Radiological Sciences Vanderbilt University School of Medicine Nashville Tennessee Systems and Structural Biology Center, RIKEN, 1-7-22 Suehiro-cho, Tsurumi, Yokohama, Kanagawa, 230-0045 Japan; Department of Biochemistry and Molecular Biology, Centre of Experimental Medicine, Nanchang University, Nanchang, Jiangxi 330006, P.R. China Department of Emergency, The Third People’s Hospital of Yunnan Province, Kunming, Yunnan, China College of Life Science and Engineering, Foshan University, Foshan Guangdong China 2Department of Otolaryngology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania. Department of Endocrinology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, China Department of Pharmacology, Nanjing Medical University, Nanjing, People's Republic of China. Department of Medicine Miller School of Medicine University of Miami Miami Florida Department of Psychology, University of Illinois at Urbana-Champaign, Champaign, Illinois 61820; and Department of Bioengineering University of Illinois at Urbana‐Champaign Urbana IL USA; Department of Radiation Oncology Carle Cancer Center, Carle Foundation Hospital Urbana IL USA Department of General Practice, Taizhou People's Hospital Taizhou 225300, Jiangsu Province, China. Department of Otolaryngology‑Head and Neck Surgery, University of California at San Francisco, San Francisco, CA 94143, USA State Key Laboratory of Fine Chemicals, Dalian University of Technology (DUT), DUT-KTH Joint Education and Research Center on Molecular Devices, Dalian 116024, China Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Wuya College of Innovation, Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, China Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation; School of Pharmacy; Tongji Medical College; Huazhong University of Science and Technology; Wuhan 430030 College of Enology, Northwest A&F University , Yangling , China; Shaanxi Engineering Research Center for Viti-Viniculture , Yangling , China Department of Obstetrics and Gynecology University of Wisconsin‐Madison Madison WI USA; Department of Rheumatology and Immunology Affiliated Hospital of Qingdao University Qingdao Shandong China Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics; Chinese Academy of Sciences; Dalian China School of Life Science and Engineering Foshan University Foshan Guangdong P.R. China 3 Technology Innovation Center for Exploration and Exploitation of Strategic Mineral Resources in Plateau Desert Region, Ministry of Natural Resources, Xining 810000, China Department of Rheumatology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong Province, China Authors' Affiliations: 1Gene Expression and Regulation Program, The Wistar Institute; 2Immune Cell Development and Host Defense Program, 3Women's Cancer Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania; and 4Kazan Federal University, Kazan, Russia Industrial Bio-materials Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 305-806, Republic of Korea; Department of Biomolecular Science, Korea University of Science and Technology, KRIBB, Daejeon 305-806, Republic of Korea College of Chemistry; Chemical Engineering and Materials Science; Collaborative Innovation Center of Suzhou Nano Science and Technology; Soochow University; Suzhou 215123, China Betta Pharmaceuticals Co., Ltd Hangzhou China The Fourth Military Medical University, School of Pharmacy, Institute of Materia Medica, 710032 Xi’an, People’s Republic of China Chongqing Key Laboratory of Green Synthesis and Applications, College of Chemistry, Chongqing Normal University, Chongqing 401331, China Department of Obstetrics and Gynecology, Third Hospital, Peking University, Beijing, China. MacroGenics Inc., Rockville State Key Laboratory of Metal Matrix Composites, School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240, P.R. China Key Laboratory of Special Function Materials and Structure Design of the Ministry of Education, School of Physical Science and Technology, Lanzhou University, Lanzhou 730000, China Katzin Diagnostic & Research PET/MR Center, Nemours/Alfred duPont Hospital for Children, Wilmington, DE 19803, USA |
Incoming Links
Total number of triples: 4371.