http://rdf.ncbi.nlm.nih.gov/pubchem/author/MD5_80d2054433a00b49722040a4d35fa69a
Outgoing Links
Predicate | Object |
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family-name | Jing Li Li |
name | Jing Li Jing. Li |
given-name | Jing Jing. |
organization-name | Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan, PR China; South Sichuan Institution for Translational Medicine, Luzhou, Sichuan, PR China; Department of Oncology and Hematology, Hospital (T.C.M.) Affiliated to Southwest Medical University, Luzhou, Sichuan, China State and Local Joint Engineering Laboratory for Novel Functional Polymeric Materials, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China Department of Nursing, Hainan Western Central Hospital, Danzhou, Hainan, China (mainland) Key Laboratory of Green Chemistry and Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu, Sichuan 610064, China Department of Chemistry and Chemical Biology, Rutgers University, 610 Taylor Road, Piscataway, New Jersey 08854, and Department of Chemistry, Campus Box 194, University of Colorado at Denver, P.O. Box 173364, Denver, Colorado 80217-3364 Department of General Surgery The Second Affiliated Hospital of Soochow University Suzhou China; Department of Hepatic Surgery Shanghai Eastern Hepatobiliary Surgery Hospital Shanghai China Department of Allergy and Clinical Immunology National Clinical Research Center for Respiratory Disease State Key Laboratory of Respiratory Disease Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University Guangzhou China Department of Pulmonary and Critical Care Medicine, Second Xiangya Hospital; Research Unit of Respiratory Disease; Diagnosis and Treatment Centre of Respiratory Disease, Central South University, Changsha, Hunan, China; Clinical Medical Research Centre for Respiratory and Critical Care Medicine in Hunan Province, China Department of Pathology Tianjin Medical University Tianjin China State Laboratory for Conservation and Utilization of Bio-resources, Yunnan University, Kunming 650091, PR China Department of Spine Surgery, Lishui Central Hospital, Lishui, China Department of Oncology and Hematology, Hospital (T.C.M) Affiliated to Southwest Medical University, Luzhou, Sichuan 646000, P.R. China Department of Radiology Changhai Hospital, Naval Medical University Shanghai China Department of Chemistry, Key Laboratory for Green Organic Synthesis and Application of Hunan Province, Key Laboratory of Environmentally Friendly Chemistry and Applications of Ministry of Education, Xiangtan University, Hunan Province 411105, China Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China Department of Intensive Care Unit, The Fourth Hospital of Xi’an, Xi’an, Shannxi Province, China. Department of Oncology, Tianjin Union Medicine Centre, 190 Jieyuan Road, Hongqiao District, Tianjin 300121, China Key Laboratory of Freshwater Aquaculture and Enhancement of Anhui Province, Fisheries Research Institute, Anhui Academy of Agricultural Sciences , Hefei 230031 , China School of Industrial and Systems Engineering, Georgia Institute of Technology, Atlanta, GA, USA Department of Epidemiology and Biostatistics, Indiana University, School of Public Health, Bloomington, IN, USA Radiation Oncology; MD Anderson Cancer Center; Houston Texas USA Hubei Province Key Laboratory on Cardiovascular, Cerebrovascular and Metabolic Disorders, Hubei University of Science and Technology, Xianning, Hubei 437100, P.R. China Guangzhou Institute of Respiratory Disease, First Affiliated Hospital of Guangzhou Medical College, Guangzhou 510120, China. jingli1016@vip.163.com College of Environmental Science and Engineering, Ocean University of China, Qingdao 266100, China Shenzhen Byoryn Technology Co., Ltd. , Shenzhen 518118 , P. R. China Department of Chemistry and Chemical Biology; Rutgers University; Piscataway; USA Key Laboratory of the Ministry of Education for Coastal and Wetland Ecosystems, College of the Environment and Ecology, Xiamen University , Xiamen 361102 , China Department of Chemistry, Capital Normal University, Xisanhuan North Road. 105, Beijing 100048, China Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin 150040, China Department of Radiation Oncology, Air Force General Hospital, Beijing 100142, P.R. China Department of Epidemiology and Biostatistics,West China School of Public Health,Sichuan University,Chengdu 610041,China. Henan Provincial Chest Hospital, Zhengzhou, P.R. China Chongqing Three Gorges Medical College, Chongqing 404120, China. State Key Laboratory of Polymer Physics and Chemistry; Changchun Institute of Applied Chemistry; Chinese Academy of Sciences; Changchun 130022, P. R. China Department of Clinical Laboratory The First Affiliated Hospital of Bengbu Medical College Bengbu Anhui People's Republic of China State Key Laboratory of Applied Organic Chemistry (SKLAOC) The Key Laboratory of Catalytic Engineering of Gansu Province College of Chemistry and Chemical Engineering Lanzhou University Lanzhou Gansu 730000 PR China Electronic Materials Research Laboratory, Key Laboratory of the Ministry of Education & International Center for Dielectric Research, Xi’an Jiaotong University, Xi’an 710049, Shaanxi, China School of Public Health, Evidence‐based Social Sciences Research Center, Health Technology Assessment Center Lanzhou University Lanzhou China Department of Cardiology, XuanWu Hospital Capital Medical University, Beijing 100053, China School of Pharmacy; Guangdong Medical University; Dongguan; China School of Industrial and Systems Engineering, Georgia Tech Atlanta Georgia USA State Key Laboratory and Institute of Elemento-Organic Chemistry, the College of Chemistry, Nankai University, Tianjin 300071, China; Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Weijin Road 94, Nankai District, Tianjin 300071, China Department of Rheumatology and Clinical Immunology, Chinese Academy of Medical Sciences and Peking Union Medical College, National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Ministry of Science and Technology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital (PUMCH), Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China. State Key Laboratory of Silicon Materials, School of Materials Science and Engineering, Zhejiang University, Hangzhou 310027, People’s Republic of China Key Laboratory of the Ministry of Education for Coastal and Wetland Ecosystems, College of the Environment and Ecology Xiamen University Xiamen China School of Chemistry and Chemical Engineering Yangzhou University Yangzhou P.R. China Department of Epidemiology and Biostatistics, School of Public Public Health, Peking University, Beijing, China. Department of Integrated Systems Engineering, The Ohio State University, OH, USA Division of Medicinal Chemistry, College of Pharmacy, and Department of Chemistry and Biochemistry, The University of Texas at Austin, Austin, Texas 78712, and Department of Chemistry and Biochemistry, Texas State University, San Marcos, Texas 78666 Department of RheumatologyPeking Union Medical College HospitalChinese Academy of Medical SciencesBeijingChina College of Natural Resources and Environment, Guangdong Provincial Key Laboratory of Agricultural & Rural Pollution Abatement and Environmental Safety, South China Agricultural University, 483 Wushan Road, Guangzhou, Guangdong 510642, China; School of Environment, Beijing Jiaotong University, 3 Shangyuancun, Haidian District, Beijing 100044, China College of Science; China Agricultural University; China Department of Emergency, Shanxi Bethune Hospital, Taiyuan, China State Key Laboratory of Advanced Welding and Joining, School of Materials Science and Engineering, Harbin Institute of Technology (Shenzhen), Shenzhen 518055, China State Key Laboratory of Pulp and Paper Engineering, South China University of Technology, Guangzhou, China; Department of Physiology and Pathophysiology; Peking University Health Science Center; Key Laboratory of Cardiovascular Science of the Ministry of Education; Beijing China Department of Cardiology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China Real World Solutions, IQVIA, Durham, NC, USA. Department of Allergy and Clinical Immunology State Key Laboratory of Respiratory Disease Guangzhou Institute of Respiratory Health The First Affiliated Hospital of Guangzhou Medical University Guangzhou China Institute of Tropical Medicine, Third Military Medical University, 30 Gaotanyan Street, Chongqing 400038, China Changchun University of Science and Technology, School of Economics and Management, Changchun, Jilin, China The University of Texas MD Anderson Cancer Center, Houston, TX Key Laboratory of Biomass Chemical Engineering of Ministry of Education College of Chemical and Biological Engineering Zhejiang University Hangzhou 310027 P.R. China Department of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 8Hutchison MediPharma Limited, Shanghai, China. State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Research Unit of Oral Carcinogenesis and Management, Chinese Academy of Medical Sciences, West China Hospital of Stomatology, Sichuan University Department of Infectious Diseases, Fifth Medical Center of Chinese PLA General Hospital National Clinical Research Center for Infectious Diseases Beijing China; 302 Clinical Medical School, Peking University Beijing China State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Ocular Surface Center, Sun Yat-sen University, Guangzhou, China; Department of Otorhinolaryngology–Head and Neck Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China Department of Traditional Chinese Medicine, Shaanxi People’s Hospital, Shaanxi Xi’an 710068, China Department of Pharmacology Nanomedicine Engineering Laboratory of Jilin Province College of Basic Medical Sciences Jilin University Changchun 130021 China Department of Psychology, Institute of Public Health, Xi’an Medical University, Xi’an, China; School of Public Health, Institute for Research on Health Information and Technology, Xi’an Medical University, Xi’an, China Department of Chemistry, Graduate School of Science, Tohoku University, 6-3 Aramaki Aza-Aoba, Aoba-ku, Sendai, Miyagi 980-8578, Japan Department of Pathology and Electron Microscopy Faculty of Basic Medical Science Harbin Medical University No. 157 Baojian Road Harbin 150086 China Key Laboratory of the Ministry of Education for Medicinal Resources and Natural Pharmaceutical Chemistry, National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest China, College of Life Sciences, Shaanxi Normal University, Xi’an, P R China Department of Neurology Xiangya Hospital Central South University Changsha China Department of Oncology & Hematology, Hospital (T.C.M) Affiliated to Southwest Medical University, Luzhou, Sichuan, PR China Emergency Resuscitation Center, Section of Emergency Medicine, Department of Medicine, University of Chicago, Chicago, IL, USA Department of Population Health Sciences Weill Cornell Medical College Cornell University New York NY USA The China PEACE Collaborative Group: NHC Key Laboratory of Clinical Research for Cardiovascular Medications National Clinical Research Center of Cardiovascular Diseases, Fuwai Hospital National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China; Central China Subcenter of the National Center for Cardiovascular Diseases Henan People's Republic of China Department of Orthodontics, Peking University School and Hospital of Stomatology, National Center for Stomatology, National Clinical Research Center for Oral Diseases, National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing Key Laboratory of Digital Stomatology, Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health, Beijing 100081, China School of Chemistry and Chemical Engineering; Jiangsu University; Zhenjiang 212013; P. R. China Department of Pharmacology, New York Medical College, Valhalla, New York 10595. Department of Senior Ward, National Clinical Research Center for Cancer, Tianjin Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer Tianjin Medical University Cancer Institute and Hospital Tianjin China Ultrasonography Department First Affiliated Hospital Heilongjiang University of Chinese Medicine Harbin Heilongjiang China Huanghuai Region Key Laboratory of Biology and Genetic Improvement of Horticultural Crops, Ministry of Agriculture and Rural Affairs, Tai'an 271018, Shandong, China. Wuhan National Laboratory for Optoelectronics Huazhong University of Science and Technology Wuhan Hubei 430074 P. R. China; School of Computer Science and Technology Huazhong University of Science and Technology Wuhan Hubei 430074 P. R. China Department of Infectious Diseases, Huashan Hospital, Fudan University, Shanghai 200040, China College of Life Science Northwest University Xi'an China Temasek Life Sciences Laboratory; Singapore Department of Blood Transfusion, The Second Hospital of Shandong University, Jinan, Shandong 250033, P.R. China Shenyang National Laboratory for Materials Science (SYNL), Institute of Metal Research (IMR) Chinese Academy of Sciences (CAS), No. 72 Wenhua Road, Shenyang 110016, China College of Horticulture, Gansu Agricultural University, Yingmen Village, Anning District, Lanzhou, Gansu 730070, People’s Republic of China Department of Cardiovascular Surgery, The First Affiliated Hospital of Medical College of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China College of Tourism and Environment Shaanxi Normal University Xi'an 710062 People's Republic of China Medical Electronic Engineering Department, Fourth Military Medical University, Xi'an, China; School of Mechanical Engineering, Northwestern Polytechnical University, Xi'an, China The Key Lab of Animal Disease and Public Health /Luoyang Key Laboratory of Live Carrier Biomaterial and Animal Disease Prevention and Control, Henan University of Science and Technology , Luoyang, Henan, China College of Plant Protection, Hebei Agricultural University, Baoding 071001, China State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, Guangdong, 510060, People's Republic of China Shanghai Academy of Agricultural Sciences/Shanghai Key Laboratory of Agricultural Genetics and Breeding, Shanghai, PR China; Shanghai Baixin Biotechnology Company Limited, Shanghai, PR China; College of Public Health, Shanghai University of Medicine & Health Sciences, Shanghai, PR China Center for Health Services Research University of Kentucky Lexington Kentucky Department of Geriatrics, Xuanwu Hospital, Capital Medical University National Clinical Research Center for Geriatric Diseases Beijing China School of Physics and Physical Engineering, Qufu Normal University, Qufu 273165, China Tianjin Eye Hospital, Tianjin Eye Institute, Tianjin Key Lab of Ophthalmology and Visual Science, Nankai University, Tianjin 300000, China. Department of Urology Shaanxi Provincial People's Hospital The Third Affiliated Hospital of the Medical College of Xi'an Jiaotong University Xi'an China State Key Laboratory of Natural Medicines Department of Pharmaceutics School of Pharmacy China Pharmaceutical University Nanjing Jiangsu P. R. China; National Medical Products Administration Key Laboratory for Research and Evaluation of Pharmaceutical Preparations and Excipients China Pharmaceutical University Nanjing Jiangsu P. R. China Research Center of Laser Fusion; China Academy of Engineering Physics; Mianyang 621900; China Department of Cardiovascular Medicine, Tianjin Chest Hospital, China Maize Research Institute, Sichuan Agricultural University , Wenjiang 611130, Chengdu, Sichuan , China Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Yushan Road, Qingdao, China; Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology, Qingdao, China National Clinical Research Center of Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of China Department of Obstetrics and Gynecology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai, China Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas; State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, P.R. China Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44 West Culture Road, 250012 Jinan, Shandong, PR China Research Center for Translational Medicine and Shanghai Heart Failure Research Center, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, People's Republic of China Department of Hepatobiliary Surgery, Xinqiao Hospital, Army Medical University, Chongqing, PR China Sanlitun Community Health Service Center, Beijing, China Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, Center of Excellence in Tissue Engineering, School of Basic Medicine Peking Union Medical College, Beijing, China. Department of Physiology, Wannan Medical College, Wuhu 241002, China.E-mail: muzisanri520@163.com. Department of Polymer Science and Engineering College of Chemistry Chemical Engineering and Materials Science Soochow University Suzhou 215123 China Department of Pharmacology and Anesthesiology, University of Illinois College of Medicine, Chicago, IL; and State Key Laboratory of Crystal Materials, Shandong University, Jinan 250100, China Department of Clinical Laboratory, the Affiliated Hospital of Qingdao University, Qingdao, China. Key Laboratory of Bio-Resources and Eco-Environment; Ministry of Education; College of Life Science; Sichuan University; Chengdu Linde + Robinson Laboratories, California Institute of Technology, Pasadena, California, USA School of Medicine, Nankai University, Tianjin, P.R. China Department of Urology, Second Hospital of Tianjin Medical University, Tianjin Institute of Urology 23 Pingjiang Road, Tianjin, 300211, China ; Department of Urology, Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital 127 Dongming Road, Zhengzhou, 450008, China. Department of Pharmacy Science, Binzhou Medical University, Yantai, Shandong264003, China Department of Rheumatology, Affiliated Hospital of Jiangsu University, Zhenjiang 212050, China Department of Rehabilitation, The Second Xiangya Hospital, Central South University, Changsha, China Animal Nutrition Institute, Sichuan Agricultural University, Chengdu, China; Key Laboratory for Animal Disease-Resistant Nutrition of the Ministry of Education of China, Sichuan Agricultural University, Chengdu, China; Key Laboratory of Animal Disease-Resistant Nutrition of Sichuan Province, Sichuan Agricultural University, Chengdu, China Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450003, P.R. China Department of Biology, Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218, USA; Thomas C. Jenkins Department of Biophysics, Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218, USA School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan, Hubei 430074, P.R. China Integrated Chinese and Western Medicine Postdoctoral research station, Jinan University, Guangzhou, Guangdong 510632, China; Formula-pattern Research Center, School of Traditional Chinese Medicine, Jinan University, Guangzhou, Guangdong 510632, China; Guangdong-Hongkong-Macau Institute of CNS Regeneration, Jinan University, Guangzhou, Guangdong 510632, China Department of Gynecological Oncology, Sun Yat‑sen Memorial Hospital, Sun Yat‑sen University, Guangzhou, Guangdong 510288, P.R.�China CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences (CAS), Beijing, China Department of Strabismus and Pediatric Ophthalmology, Tianjin Medical University Eye Hospital, Tianjin, China Key Laboratory of Eco‐Environment‐Related Polymer Materials of Ministry of Education, Key Laboratory of Polymer Materials of Gansu Province, College of Chemistry and Chemical Engineering Northwest Normal University Lanzhou 730070 China Department of Ultrasound, The Second Affiliated Hospital of Xi'an Medical College, Xi'an, Shaanxi 710038, P.R. China Department of Pediatric, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering; Key Laboratory for Bio-Nanotechnology and Molecular Engineering of Hunan Province; Hunan University; Changsha; China 1Department of Oncology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.; 2Key-Discipline Laboratory of Clinical Medicine Henan, Zhengzhou, China. Department of Pharmacy, Xiangya Hospital, Central South University, Changsha 410008, China; National Clinical Research Center for Geriatric Disorders, Institute for Rational and Safe Medication Practices, Xiangya Hospital, Central South University, Changsha 410008, China Department of Surgery University of Kentucky Lexington KY USA; Markey Cancer Center University of Kentucky Lexington KY USA Department of Integrated System Engineering, Ohio State University, Columbus, OH, USA Alnylam Pharmaceuticals, Inc., Cambridge, MA 02142, USA Department of Urology First Affiliated Hospital of Zhengzhou University Zhengzhou Henan China Department of Atmospheric and Oceanic Sciences, School of Physics, Peking University, Beijing, 100871, China The Second General Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China Department of Chemistry, Liaocheng University, Liaocheng 252059, China School of Life Science and Technology, ShanghaiTech University, 100 Haike Road, Shanghai 201210, P.R. China State Key Laboratory of Bioorganic and Natural Products Chemistry Shanghai Institute of Organic Chemistry Chinese Academy of Sciences Shanghai P. R. China; School of Physical Science and Technology Shanghai Tech University Shanghai P. R. China The State Key Laboratory of Power Transmission Equipment & System Security and New Technology; Chongqing Key Laboratory of Chemical Process for Clean Energy and Resource Utilization; School of Chemistry and Chemical Engineering, Chongqing University; Chongqing 400044; P. R. China State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Provincial Key Laboratory of Pharmaceutics, Guizhou Medical University, Guiyang, 550004 Guizhou, PR China; School of Pharmacy, Guizhou Medical University, Guiyang, 550004 Guizhou, PR China Provincial-Level Key Laboratory for Molecular Medicine of Major Diseases and The Prevention and Treatment with Traditional Chinese Medicine Research in Gansu Colleges and Universities, Gansu University of Chinese Medicine, Lanzhou, China. Department of Gastroenterology, Tongji Hospital, Tongji University, Shanghai, China From the Singapore Eye Research Institute, the School of Pharmaceutical Sciences Shandong University of Traditional Chinese Medicine Jinan China Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs; School of Pharmacy; Shanghai Jiao Tong University; Shanghai 200240; P. R. China Department of Endocrinology & Metabolism, Renmin Hospital of Wuhan University, Wuhan, China Joint National Laboratory for Antibody Drug Engineering, The First Affiliated Hospital, School of Medicine Henan University Kaifeng China Department of Spine Surgery The Second Xiangya Hospital Central South University Changsha China For the author affilations, please see the Appendix. Department of Hematology Zhongshan Hospital, Fudan University Shanghai China Hefei National Research Center for Physical Sciences at the Microscale, Department of Materials Science & Engineering, CAS Key Laboratory of Materials for Energy Conversion, University of Science and Technology of China, Hefei, Anhui 230026, China Exercise and Health Research Center/Department of Kinesiology, Shenyang Sport University, Shenyang, 110102 Liaoning, China Microelement Research Center, Huazhong Agricultural University, Wuhan, China; Key Laboratory of Arable Land Conservation (Middle and Lower Reaches of Yangtze River), Ministry of Agriculture and Rural Affairs, Wuhan, China Department of Clinical Laboratory Science, The Affiliated Hospital of Qingdao University, 19 Jiangsu Road, Qingdao, Shandong 266003, China. Third Military Medical University, China Department of Molecular Pharmacology School of Medicine Nankai University Tianjin Tianjin 300071 China Weldon School of Biomedical Engineering, Purdue University, 206 S Martin Jischke Dr, West Lafayette, IN 47907, USA Laboratory of Immunobiology, Dana-Farber Cancer Institute, and Department of Medicine, Harvard Medical School, Boston, MA 02115; and Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115 School of Materials and Chemical Engineering, Xuzhou University of Technology, Xuzhou, Jiangsu 221018, P. R. China Key Laboratory of Bioresources and Ecoenvironment (Ministry of Education) College of Life Sciences Sichuan University Chengdu 610064 China; Sichuan Key Laboratory of Conservation Biology on Endangered Wildlife College of Life Sciences Sichuan University Chengdu Sichuan 610064 China School of Chemical and Biological Engineering, Yichun University, Yichun, Jiangxi 336000, China. wblong77 @126.com. Department of Chemical Engineering, Sichuan University, Chengdu 610065, China; Beijing Key Laboratory of Green Chemical Reaction Engineering and Technology, Department of Chemical Engineering, Tsinghua University, Beijing 100084, China Department of Cardiology General Hospital of Shenyang Military Region Shenyang 110016 China College of Pharmaceutical Sciences; Zhejiang University; Hangzhou 310058; China Department of Hepatobiliary Surgery, The Second Affiliated Hospital of Army Medical University, Chongqing, China School of Pharmacy; Shanghai Jiao Tong University; Shanghai 200240; China Department of Physiology, School of Basic Medical Sciences, Xinjiang Medical University, Urumqi, Xinjiang, China Program in Cellular and Molecular Medicine, Boston Children’s Hospital, Boston, MA 02115;; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115; School of Biological Sciences, University of Western Australia, Perth, WA 6009, Australia Department of Pediatrics, University of Chicago, Chicago, Illinois; and Albert Einstein Cancer Center, Department of Medicine and Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, New York From the Departments of Medicine and Family and Preventive Medicine, University of California, San Diego; the Department of Veterans Affairs Medical Center, San Diego; and Charles R. Drew University of Medicine and Science, Los Angeles, Calif. Department of Rheumatology, Affiliated Hospital of Nantong University, Nantong, Jiangsu 22600, P.R. China Department of Urologic Oncosurgery Affiliated Cancer Hospital & Institute of Guangzhou Medical University Guangzhou China Department of Pharmacology, New York Medical College, Valhalla, New York 10595, USA. Department of Oncology, Huashan Hospital, Fudan University, Shanghai 200040, China Key Laboratory for Anisotropy and Texture of Materials (Ministry of Education); Northeastern University; Shenyang, Liaoning 110819; China; Institute of Ceramics and Powder Metallurgy Department of Genetics; University of Alabama at Birmingham; Birmingham AL Department of Nephrology, First Central Hospital of Tianjin, Tianjin, People’s Republic of China State Key Laboratory of Coordination Chemistry; School of Chemistry and Chemical Engineering; Nanjing University; Nanjing 210023; China Guangdong Provincial Key Laboratory of Quantum Engineering and Quantum Materials, Institute for Advanced Materials, South China Academy of Advanced Optoelectronics, South China Normal University, Guangzhou 510006, P. R. China Laboratory of Cellular Biology, College of Basic Medicine, Jilin University, Changchun, Jilin 130021, China. Diagnosis Institute of Traditional Chinese Medicine, Hunan University of Chinese Medicine Changsha 410208, China. Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas Hematology Center, Beijing Key Laboratory of Pediatric Hematology Oncology, National Key Discipline of Pediatrics (Capital Medical University), Key Laboratory of Major Diseases in Children, Ministry of Education, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, China School of Environmental and Safety Engineering, Advanced Plasma Catalysis Engineering Laboratory for China Petrochemical Industry, Changzhou University, Changzhou, Jiangsu 213164, China; Engineering Research Center of Construction Technology of Precast Concrete of Zhejiang Province, Hangzhou 310018, China CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, People's Republic of China. Fourth Military Medical University, Department of Radiation Medicine, Xi'an, P. R. China SINO‐US Diagnostics Tianjin Enterprise Key Laboratory of AI‐aided Hematopathology Diagnosis Tianjin China Department of Gynecology and Obstetrics, Tongji Hospital, Tongji Medical College, Huazhong Science and Technology University, Wuhan 430030, P. R. China. Department of Psychiatry, First Affiliated Hospital of Kunming Medical University , Kunming , China Department of Allergy and Clinical Immunology, National Clinical Research Center for Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China. Electronic address: lijing@gird.cn. Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, 610 Taylor Road, Piscataway, New Jersey 08852, United States Biomaterial R&D Center of China Institute for Radiation Protection, Shanxi Osteorad Biomaterial Co., Ltd, Taiyuan Shanxi, 030006, P. R. China. State Key Laboratory of Silicon Materials, School of Materials Science and Engineering, Zhejiang University, Hangzhou 310027, China Tianjin University for the mAF-App II Trial investigators Institute of Animal Nutrition and Ministry of Education of ChinaSichuan Agricultural UniversityChengduChina; Key Laboratory for Animal Disease‐Resistant NutritionMinistry of Education of ChinaSichuan Agricultural UniversityChengduChina The Key Laboratory of Fuel Cell Technology of Guangdong Province, School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510641, China Department of Pharmacy, Lu’an Hospital of Anhui Medical University, Lu’an People’s Hospital of Anhui Province, Lu’an Department of Hematology, Tianjin Medical University General Hospital, Tianjin, China Department of Cell Biology, University of Alberta, Edmonton, Canada. jli4@ualberta.ca National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China Department of Plastic and Burn Surgery, Tangdu Hospital, Forth Military Medical University, Xi’an, Shaanxi 710038, China State Key Laboratory of Bioorganic and Natural Products Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai200032, China; School of Physical Science and Technology, ShanghaiTech University, Haike Road 100, Shanghai200120, China Department of Gastroenterology, West China Hospital, Sichuan University, Chengdu, China Hainan Key Laboratory of Tropical Oil Crops Biology/Coconut Research Institute, Chinese Academy of Tropical Agricultural Science, Wenchang, Hainan 571339, China Institute of Pharmaceutical Research and Development, College of Pharmacy, Wonkwang University; Department of Pharmacy, Jiujiang University Affiliated Hospital Department of Gastroenterology, First Affiliated Hospital, Jinzhou Medical University, Jinzhou, Liaoning, China Key Laboratory of Functional Inorganic Material Chemistry; School of Chemistry and Materials; Heilongjiang University; Ministry of Education; Harbin 150080, P. R. China School of Public Health, Kunming Medical University, Kunming, Yunnan, China; NHC Key Laboratory of Drug Addiction Medicine, Kunming Medical University, Kunming, Yunnan, China Department of Urology, Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, Henan, China Department of Minimal-Invasive Intervention, The Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer Hospital, Zhengzhou, China Department of Ophthalmology, Guangdong Women and Childrens’ Hospital, Guangzhou, Guangdong, China (mainland) Wenzhou University College of Chemistry and Materials Engineering Wenzhou 325035 China Yunnan Key Laboratory of Vaccine Research and Development on Severe Infectious Diseases, Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming, People’s Republic of China Institute for Immunity, Transplantation and Infection, School of Medicine, Stanford University, Stanford, CA 94305; College of Agricultural and Life Sciences, Kunming University, Kunming 650214, China Department of Chemistry; Graduate School of Science; Tohoku University; Sendai 980-8578; Japan Key Laboratory of Magnetic Molecules & Magnetic Information Materials Ministry of Education; The School of Chemical and Material Science; Shanxi Normal University; Linfen 041004; China Department of Chemistry; University of Oxford; Physical & Theoretical Chemistry Laboratory; Oxford; UK Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun, P. R. China Tianjin Key Lab of Ophthalmology and Visual Science Tianjin Eye Institute Tianjin Eye Hospital Clinical College of Ophthalmology Tianjin Medical University Tianjin China Mental Health Center, West China Hospital, Sichuang University, Chengdu, China College of Power Engineering, Naval University of Engineering, No. 717, Jiefang Road, Qiaokou District, Wuhan 430033, P. R. China Business School, Lanzhou City University, Lanzhou, China Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, People’s Republic of China Department of Radiology, Beijing Tongren Hospital Capital Medical University Beijing China Department of Urology, Cancer Center of Guangzhou Medical University, Guangzhou, P. R. China Department of Physiology, Basic Medical College, Jiamusi University, Jiamusi, Heilongjiang 154007, P.R. China Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan 430071, China The Second Department of Orthopaedics, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, Shaanxi, China. Department of Pharmacy, Affiliated Hospital of Qingdao University, Qingdao, China Department of Pharmacology, School of Medicine, Nankai University, Tianjin, China; Assisted Reproduction Unit, Department of Obstetrics and Gynecology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Key Laboratory of Reproductive Dysfunction Management of Zhejiang Province, Hangzhou, China Department of Gynecology Harbin Medical University Cancer Hospital Harbin Heilongjiang China Sinovac Biotech Co., LTD., Beijing, China Department of Epidemiology and Biostatistics, West China School of Public Health and West China Fourth Hospital Sichuan University Chengdu China School of Medicine, University of Leeds, Leeds LS2 9JT, UK Department of Chemistry, Liaocheng University, Liaocheng, Shandong 252059, China School of Materials Science and Engineering, Northeastern University, Shenyang 110819, China; Foshan Graduate School of Northeastern University, No. 2, Zhihui Road, Shunde District, Foshan 528300, China Department of Traditional Chinese Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China Department of Surgery (J.L., J.S., B.M.E.) University of Kentucky, Lexington, Kentucky 40536; Lucille P. Markey Cancer Center (J.L., J.S., H.L.W., T.W., B.M.E.), University of Kentucky, Lexington, Kentucky 40536 Key Laboratory of Feed Biotechnology of the Ministry of Agriculture and Rural Affairs, Institute of Feed Research, Chinese Academy of Agricultural Sciences, Beijing 100081, China Division of Nephrology, Huashan Hospital, Fudan University, Shanghai, China Hunan University of Chinese Medicine Changsha 410208, China Hunan Key Laboratory of Colleges and Universities of Intelligent Traditional Chinese Medicine Diagnosis and Preventive Treatment of Chronic Diseases,Hunan University of Chinese Medicine Changsha 410208, China. Gynecology, Wuhan Children’s Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China Institute of Psychology, Chinese Academy of Sciences,CAS Key Laboratory of Behavioral Science,Beijing,China Shanghai University of Medicine and Health Sciences Affiliated Sixth People's Hospital South Campus 6600 Nanfeng Road Shanghai 201400 China Department of Cardiology, Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of Zhejiang Province, Sir Run Run Shaw Hospital, School of Medicine Zhejiang University Hangzhou 310016 China; Department of Cardiology Jinhua Wenrong Hospital Jinhua 322118 China Center for Translational Medicine, the First Affiliated Hospital of Xi’an Jiaotong University College of Medicine, Xi’an, Shaanxi 710061, People’s Republic of China. Department of Pediatrics, Department of Pharmacological and Physiological Sciences, University of Chicago, Chicago, Illinois Department of Pancreatic-Hepatobiliary Surgery, The Second Affiliated Hospital, Army Medical University, People's Liberation Army, Chongqing, Chongqing Municipality, China; Department of Hepatobiliary Surgery, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan Province, China. Division of National HIV/HCV Reference Laboratory, National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China. Department of Pathology Harbin Medical University Harbin China Key Laboratory of Human Disease Comparative Medicine NHFPC Institute of Laboratory Animal Science Chinese Academy of Medical Sciences & Comparative Medical Center Peking Union Medical College Beijing China Divisions of Cardiovascular Diseases (A.J.F., M.G., J.L., Y.M., M.R., D.L., R.D.S., A.L.), Rochester, Minnesota 55905 Department of Critical Care Medicine, Children's Hospital of Chongqing Medical University, Chongqing 400014, China. Corresponding author: Tan Liping, Email: tanlp0825@hotmail.com. School of Information Engineering, Nanchang University, Nanchang 330031, China Temasek Life Sciences Laboratory, National University of Singapore, Singapore 117604; and; Department of Biological Sciences, National University of Singapore, Singapore 117543 Key Laboratory of Chemical Biology (Ministry of Education), Institute of Pharmacognosy, School of Pharmaceutical Sciences, Shandong University, Jinan, Shandong 250012, People’s Republic of China Department of Epidemiology and Biostatistics School of Public Health, Peking University Health Science Center Beijing China Department of Otolaryngology, Head and Neck Surgery, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing, People’s Republic of China Department of Pathology, Zibo Central Hospital, Zibo 2550036, China Department of Gastroenterology State Key Laboratory of Organ Failure Research Guangdong Provincial Key Laboratory of Gastroenterology Nanfang Hospital Southern Medical University Guangzhou China; Department of Gastroenterology The First Affiliated Hospital of Zhengzhou University Zhengzhou China School of Physics and Technology, Wuhan University, Wuhan 430072, People’s Republic of China Sunshine Lake Pharma Co., Ltd. (HEC), Guangdong 523871, China State Key Laboratory of Applied Organic Chemistry (SKLAOC) College of Chemistry and Chemical Engineering Lanzhou University Lanzhou Gansu 730000 P. R. China; Gansu Provincial Engineering Laboratory for Chemical Catalysis College of Chemistry and Chemical Engineering Lanzhou University Lanzhou Gansu 730000 P. R. China Department of Rheumatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences; Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education & National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID) CSIRO Waite Campus Urrbrae SA 5064 Australia; College of Tourism and Environment Shaanxi Normal University Xi'an Shaanxi 710062 China College of Integrated Chinese and Western Medicine, Hebei Medical University, Shijiazhuang 050017, Hebei, China; Department of Traditional Chinese Medicine, Tumor Hospital of Hebei Province, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, Hebei, China Mental Health Center, West China Hospital of Sichuan University , Chengdu 610041, China Department of Radiology Affiliated Hospital of Guizhou Medical University 28 Guiyi Road Guiyang China Department of Endocrinology Health Management Center Tianjin Union Medical Center Nankai University Affiliated Hospital Tianjin China Department of Oral and Maxillofacial Surgery Hospital of Stomatology China Medical University Shenyang China; Liaoning Provincial Key Laboratory of Oral Diseases Shenyang China Reproductive Medical Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China; State Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, 678 Haping Road, Harbin 150069, China Department of Pathology, Central Hospital of Zibo, Shandong, China Department of Endoscopic Diagnosis and Treatment Center Affiliated Cancer Hospital of Zhengzhou University Zhengzhou China Zhong-Da Hospital, Southeast University, Nanjing, China Department of Pharmaceutical Sciences, Center for Drug Delivery and Nanomedicine University of Nebraska Medical Center, Durham Research Center 985830 Nebraska Medical Center Omaha NE 68198‐5830 USA University of Manitoba, Winnipeg 1 Department of Physics and Astronomy, , Manitoba R3T 2N2, Canada College of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, China; Key Laboratory of Environment Correlative Dietology, Ministry of Education, Huazhong Agricultural University, Wuhan 430074, China Department of Forensic Medicine, School of Basic Medicine and Biological Sciences, Soochow University, Suzhou 215123, China Department of Traditional Chinese Medicine Shaanxi Provincial People's Hospital Xi'an China Department of Geriatrics, The Second Hospital of Harbin Medical University, Harbin, Heilongjiang, P.R. China Mental Health Center, West China Hospital of Sichuan University , No. 28 Dian Xin Nan Jie, Wuhou District, Chengdu , China Shire (a member of the Takeda group of companies) Lexington Massachusetts USA Department of Cellular and Molecular Physiology, Yale University, New Haven, Connecticut; Department of Basic Medical Science, Chengdu Medical College, Chengdu, China Environment Research Institute, Shandong University, 72 Binhai Road, Qingdao 266237, China State Key Laboratory of Bioelectronics Jiangsu Key Laboratory for Biomaterials and Devices School of Biological Sciences and Medical Engineering Southeast University Nanjing 210096 P. R. China Department of Urology, Cancer Center of Guangzhou Medical University, Guangzhou, People's Republic of China State Key Laboratory of Bioelectronics Jiangsu Key Laboratory for Biomaterials and Devices School of Biological Sciences and Medical Engineering Southeast University Nanjing 201196 P. R. China Department of Cadre Ward, The 181st Hospital of Chinese People's Liberation ArmyGuilin 541002, China. From the Center for Reproductive Medicine, Shandong Provincial Hospital–Shandong University, the Key Laboratory of Reproductive Endocrinology of Ministry of Education, and the National Research Center for Assisted Reproductive Technology and Reproductive Genetics (Y. Shi, D.W., Z.W., M.S. H. Liu, J.L., L.Z., Z.-J.C.), and the Center for Reproductive Medicine, Qilu Hospital of Shandong University (X.D.), Jinan, the Center for Reproductive Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong... Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, People’s Republic of China State Key Laboratory of Chemo/Biosensing and Chemometrics; College of Chemistry & Chemical Engineering; Key Laboratory for Bio-Nanotechnology and Molecular Engineering of Hunan Province; Hunan University; Changsha 410082 Academy for Advanced Interdisciplinary Research, North University of China, Taiyuan 030051, China; Center for Microsystem Intergration, North University of China, Taiyuan 030051, China; School of Instrument and Intelligent Future Technology, North University of China, Taiyuan 030051, China; School of Instrument and Electronics, North University of China, Taiyuan 030051, China Key Laboratory for Organic Electronics and Information Displays & Jiangsu Key Laboratory for Biosensors; Institute of Advanced Materials; Jiangsu National Synergetic Innovation Centre for Advanced Materials; Nanjing University of Posts and Telecommunications (NJUPT); Nanjing 210023 Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing 100029, China. Department of Otolaryngology; Affiliated Eye and Ear, Nose and Throat Hospital; Shanghai Medical College; Fudan University; Shanghai China International Joint Research Center for Smart Agriculture and Water Security of Yunnan Province, Yunnan Agricultural University, Kunming 650201, China Department of Spine Surgery, The Second Xiangya Hospital of Central South University, No.139, Renmin Middle Road, Changsha 410011, China Department of Rheumatology and Clinical Immunology, Peking Union Medical College and Chinese Academy of Medical Sciences; National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Ministry of Science & Technology; State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital (PUMCH), Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education , Beijing , China Department of Ophthalmology, Children's Hospital of Soochow University, Suzhou, Jiangsu 215025, P.R. China Geneplus‐Beijing Institute Beijing China; Geneplus‐Beijing Beijing China Department of Oncology, Wayne State University School of Medicine, Detroit, Michigan 48201, United States; Barbara Ann Karmanos Cancer Institute, Detroit, Michigan 48201, United States College of Chemistry Sichuan University Chengdu P. R. China Department of Pediatrics and the Ben May Institute for Cancer Research, University of Chicago, Chicago, Illinois; Herbert Irving Comprehensive Cancer Center, College of Physicians and Surgeons, Columbia University, New York; and Department of Medicine and Developmental and Molecular Biology, Albert Einstein Cancer Center, Albert Einstein College of Medicine, New York, New York Anshun University, Guizhou Anshun 561000, China Department of Spine Surgery, Second Xiangya Hospital, Central South University, Changsha 410011,China. State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201620, China School of Marine Sciences, Sun Yat-sen University, Guangzhou 510006, P. R. China Department of Orthopaedics, Tianjin Medical University General Hospital, Tianjin, China Department of Ultrasound, Tianjin Union Medical Center, Nankai University, Tianjin 300121, China. Institute of Environmental Processes and Pollution Control, and School of Environment and Civil Engineering, Jiangnan University, Wuxi, Jiangsu 214122, People’s Republic of China; Jiangsu Engineering Laboratory for Biomass Energy and Carbon Reduction Technology, Jiangnan University, Wuxi, Jiangsu 214122, People’s Republic of China; Jiangsu Key Laboratory of Anaerobic Biotechnology, Jiangnan University, Wuxi, Jiangsu 214122, People’s Republic of China Key Laboratory for Organic Electronics & Information Displays (KLOEID), Institute of Advanced Materials (IAM), National Syngerstic Innovation Center for Advanced Materials (SICAM), Jiangsu Key Laboratory for Biosensor, Nanjing University of Posts & Telecommunications, 9 Wenyuan Road, Nanjing 210023 China Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Pharmacy, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China Department of Ophthalmology, The First Affiliated Hospital of Chengdu Medical College, Chengdu, China Department of Physiology, First Affiliated Hospital of Jiamusi University, Jiamusi, China. Department of Infectious Diseases, Shunde Hospital, Southern Medical University, Shunde, Guangdong 528308, China Department of Neurology, Daping Hospital, Third Military Medical University, Chongqing 400042, China; Sports Center, Xi’an Jiaotong University, Shaanxi 710049, Xi’an, China Chongqing Key Laboratory of Inorganic Special Functional Materials, College of Chemistry and Chemical Engineering, Yangtze Normal University, Fuling, Chongqing 408100, China Department of Applied Chemistry China Agricultural University Beijing China State Key Laboratory of Military Stomatology National Clinical Research Center for Oral Diseases Shaanxi Key Laboratory of Stomatology Department of Prosthodontics School of Stomatology The Fourth Military Medical University 145 Changle West Road Xi'an Shaanxi 710032 P. R. China Department of Radiation Oncology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China. State Key Laboratory of Natural Medicines and Department of Pharmaceutics China Pharmaceutical University Nanjing 210009 China Department of Pharmacy, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China (mainland) Guangdong Provincial Key Laboratory of Liver Disease Research, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China Department of Respiratory Medicine, Guangdong Provincial People's Hospital, Guangzhou 510080, China. Peking University First Hospital Beijing China Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan 528400, China State Key Laboratory of Military Stomatology and National Clinical Research Center for Oral Diseases and Shaanxi Key Laboratory of Stomatology Department of Prosthodontics School of Stomatology The Fourth Military Medical University Xi'an Shaanxi 710032 China Department of Surgical Oncology The First Affiliated Hospital of Bengbu Medical College Bengbu City China State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China, and University of the Chinese Academy of Sciences, Beijing 100039, China State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, P. R. China; Graduate School of the Chinese Academy of Sciences, Beijing, 100039, P. R. China Department of Orthopaedics, Ghent University Hospital, Ghent, Belgium. CAS Key Laboratory of Biofuels, Shandong Key Laboratory of Energy Genetics and BioEnergy Genome Center, Qingdao Institute of BioEnergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao, Shandong 266101, China (J.L.) From the Department of Neurology, Daping Hospital, Third Military Medical University, Chongqing, China. Department of Anatomy, Academy of Basic Medicine, Jining Medical University, Shandong, China; lijing800912@yahoo.com.cn. Key Laboratory of Luminescence Analysis and Molecular Sensing (Southwest University), Ministry of Education, College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, P. R. China Key Laboratory for Polymeric Composite and Functional Materials of Ministry of Education Key Laboratory of High Performance Polymer‐based Composites of Guangdong Province School of Chemistry Sun Yat‐sen University Guangzhou 510275 China College of Life Science and Technology, Huazhong Agricultural University, Wuhan, Hubei Province, China School of Public Health, Nantong University, Nantong 226019, P. R. China CAS Key Laboratory of Urban Pollutant Conversion, Department of Applied Chemistry, University of Science and Technology of China, Hefei 230026, China Institute of Systems Epidemiology, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu 610041, China Center for Translational Medicine, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, People’s Republic of China Department of Applied Chemistry China Agricultural University Beijing P. R. China Division of Dermatology Rush University Medical Center Chicago Illinois USA School of Environmental Science and Engineering, Suzhou University of Science and Technology, Suzhou 215009, China. Contribution from the Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, New Jersey 08854 From the Institute of Membrane and Systems Biology (S.-Z.X., F.Z., J.L., P.S., A.M.D., P.K.F., D.M., J.N., A.C., A.N.B., D.J.B.), University of Leeds, United Kingdom; Cellular Pharmacology (K.M.), School of Pharmacy, Aichi Gakuin University, Nagoya, Japan; School of Medicine (K.E.P.), University of Leeds, United Kingdom; and Yorkshire Heart Centre (S.S., C.M.M.), General Infirmary at Leeds, United Kingdom. Sichuan Key Laboratory of Conservation Biology on Endangered Wildlife College of Life Sciences Sichuan University Chengdu Sichuan 610064 China Functional Nanomaterials Laboratory, Center for Micro/Nanomaterials and Technology, and Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Zhongguancundonglu 29, Haidianqu, Beijing 100190, China Institute of Plant Protection, Jiangsu Academy of Agricultural Sciences Jiangsu Key Laboratory for Food and Safety‐State Key Laboratory Cultivation Base of Ministry of Science and Technology Nanjing China; College of Plant Protection Nanjing Agricultural University Nanjing China Department of Pediatric, The Affiliated Hospital of Changchun University of Chinese Medicine Changchun, China. Key Laboratory for Space Bioscience and Biotechnology, School of Life Sciences Northwestern Polytechnical Univ 127 Youyi Xilu Xi'an Shaanxi 710072 China Departments of Neurological Surgery and Department of Ultrasonic medicine The 1st Affiliated Hospital of Heilongjiang University of Chinese Medicine Harbin China College of Pharmacy, Southwest University, Chongqing, People's Republic of China Temasek Life Sciences Laboratory, 1 Research Link, National University of Singapore, 117604 Singapore; Department of Biological Sciences, National University of Singapore, 117845 Singapore Group of cell motility and muscle contraction, National Laboratory of Integrated Management of Insect Pests and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China Beijing Key Laboratory of DNA Damage Response and College of Life Science, Capital Normal University, Beijing, China State Key Laboratory of Silicon Materials, School of Materials Science and Engineering, Zhejiang University, Hangzhou 310027, P. R. China Endocrinology, The Affiliated Nanhua Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, China Department of Pediatrics, Guangdong Women and Children Hospital, Guangzhou, China Radiology Department Tangshan Maternal and Child Health Hospital Tangshan China Department of Nephrology, Affiliated Hospital of Qingdao University Qingdao, China. School of Pharmacy,Shaanxi University of Chinese Medicine Xi'an 712046,China State Key Laboratory of Dao-di Herbs Breeding Base,Joint Laboratory of Infinitus (China) Herbs Quality Research,National Resource Center for Chinese Materia Medica,China Academy of Chinese Medical Sciences Beijing 100700,China. Department of Pharmacy Affiliated Hospital of Qingdao University Qingdao China University of Arizona, Tucson, Arizona Department of Pathology Tianjin Medical University Tianjin China; Department of Pathology General Hospital of Tianjin Medical University Tianjin China National Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry Production, Hunan Province Key Laboratory of Animal Nutritional Physiology and Metabolic Process, Key Laboratory of Agro‐ecological Processes in Subtropical Region Institute of Subtropical Agriculture, Chinese Academy of Sciences Changsha China Center for Reproductive Medicine, Shandong Provincial Hospital Affiliated to Shandong University, 157 Jingliu Road, Jinan, China; National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Key Laboratory of Reproductive Endocrinology (Shandong University), Ministry of Education, 157 Jingliu Road, Jinan, China; Shandong Provincial Key Laboratory of Reproductive Medicine, 157 Jingliu Road, Jinan, China Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, People's Republic of China Department of Hepatobiliary Surgery, Xinqiao Hospital Third Military Medical University Chongqing P. R. China Department of Gastroenterology, Tongji Hospital of Tongji University, Shanghai, China School of Microelectronics, Dalian University of Technology, No. 321 Tuqiang Road, Dalian 116620, China; Key Laboratory of Materials Modification by Laser, Ion, and Electron Beams (Ministry of Education), School of Physics, Dalian University of Technology, No. 2 Linggong Road, Dalian 116024, China State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China; University of Chinese Academy of Sciences, Beijing 100039, China Institute of Basic Medical Sciences & School of Basic Medicine, Center of Excellence in Tissue Engineering, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100005, China Professor of Medicine, Laboratory of Stem Cell and Tissue Engineering, Department of Histology and Embryology, Chongqing Medical University. State Key Laboratory of Protein and Plant Gene Research, School of Life Sciences, Peking University, 100871 Beijing, China; College of Marine Life Sciences; Ocean University of China; Qingdao 266003; People's Republic of China The University of Texas MD Anderson Cancer Center Houston Texas USA Department of Psychiatry, West China Hospital of Sichuan University, Chengdu, China, University of Arizona Health Sciences Center, Tucson, Arizona State Key Laboratory of Functional Materials for Informatics; Shanghai Institute of Microsystem and Information Technoloy (SIMIT); Chinese Academy of Sciences; Shanghai 200050; China State Key Laboratory for Mesoscopic Physics and School of Physics, Peking University 1 , Beijing 100871, China MD Anderson Cancer Center, Houston, TX, USA Research Institute of Clinical Medical Science, Gansu Provincial Maternity and Child-care Hospital, Lanzhou, China Department of Endocrinology, Chinese PLA General Hospital, Beijing, China. Department of Oncology, The Seventh Affiliated Hospital Sun Yat-sen University, Shenzhen, Guangdong, 518107, PR China Authors' Affiliations: Departments of 1Surgery, 2Internal Medicine, and 3Biostatistics; 4Markey Cancer Center, University of Kentucky, Lexington, Kentucky; and 5Department of Surgery, University of Texas Medical Branch, Galveston, Texas; Authors' Affiliations: Departments of 1Surgery, 2Internal Medicine, and 3Biostatistics; 4Markey Cancer Center, University of Kentucky, Lexington, Kentucky; and 5Department of Surgery, University of Texas Medical Branch, Galveston, Texas Department of Hospital Infection, Chengdu Women's and Children's Central Hospital, School of Medicine University of Electronic Science and Technology of China Chengdu China Ultrasound medical center, Lanzhou University Second Hospital Lanzhou Gansu China Beijing Key Lab of TCM Collateral Disease Theory Research, School of Traditional Chinese Medicine Capital Medical University Beijing 100069 PR China Department of Nutrition, Institute of Health & Environmental Medicine, Academy of Military Medical Sciences, Tianjin 300050, China ; Department of Nutrition and Food Hygiene, College of Public Health, Zhengzhou University, Zhengzhou 450001, Henan Province, China. School of Life Science; Qufu Normal University; Qufu 273165; China Key Laboratory for Biomechanics and Mechanobiology of the Ministry of Education, Beijing Advanced Innovation Centre for Biomedical Engineering, School of Engineering Medicine, Beihang University, Beijing, China College of Food Science and Technology, Hunan Agricultural University, Changsha 410128, China Department of Electrical Engineering and Computer Science, Case Western Reserve University, Cleveland, OH 44106. Donggang Center Hospital, Donggang, China Department of Central Laboratory, 89 Hospital of PLA Weifang, Shandong Province, China. Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724; Dana–Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, MA 02115; and Departments of Pathology and Medicine, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, New York, NY 10032 State Key Laboratory of Drug Research, National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, People’s Republic of China Department of Cardiology, Hospital Affiliated to Shenyang Medical College, Shenyang, Liaoning 110021, P.R. China Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas. Return Visit Office, Cangzhou Central Hospital, Cangzhou, Hebei 061000, P.R. China Horticulture Research Institute, Sichuan Academy of Agricultural Sciences, Chengdu 610066, China; Key Laboratory of Horticultural Crop Biology and Germplasm Creation in Southwestern China of the Ministry of Agriculture and Rural Affairs, Chengdu 610066, China From the Department of Human Oncology, University of Wisconsin Comprehensive Cancer Center, Madison, WI; and Oncology Clinical Development, Pharmacyclics, Sunnyvale, CA Beijing National Laboratory for Condensed Matter Physics Institute of Physics Chinese Academy of Sciences Beijing 100190 China; School of Physical Sciences University of Chinese Academy of Sciences Beijing 100190 China Program in Cellular and Molecular Medicine, Boston Children’s Hospital, Boston, MA 02115; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115 Beijing Key Laboratory of Oil and Gas Pollution Control College of Geosciences China University of Petroleum Beijing Beijing China Department of Hematology, Zhongda Hospital, Southeast University, Nanjing 210009, Jiangsu Province, China. Key Laboratory of Cluster Science, Ministry of Education of China, Beijing Key Laboratory of Photoelectronic/Electrophotonic Conversion Materials, School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing 100081, P. R. China CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences , Beijing 100101, China Department of Cardiovascular Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China; and Department of Otolaryngology, Affiliated Hangzhou First People's Hospital, School of Medicine, Zhejiang University Hangzhou, Zhejiang Province, China. Department of Ophthalmology, Xinhua Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China Jiangxi Provincial Institute of Traditional Chinese Medicine Nanchang 330046, China Jiangxi Research Center for Protection and Development of Traditional Chinese Medicine Resources Nanchang 330046, China. Department of Tuberculosis, No.309 Hospital of PLA, Beijing, China. Institute of Medical Biology, Chinese Academy of Medical Sciences, Yunnan Key Laboratory of Vaccine Research & Development on Severe Infectious Disease Kunming China National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China. College of Applied Sciences, Beijing University of Technology, Beijing, P. R. China Department of Bioinformatics and Biostatistics, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China Institute of Crop Sciences, The National Key Facility for Crop Gene Resources and Genetic Improvement and CIMMYT China office, Chinese Academy of Agricultural Sciences, Beijing, China School of Ecology and Environment, Beijing Technology and Business University, Beijing 100048, China Department of Public Health and General Medicine, Anhui University of Chinese Medicine, Hefei, Anhui, China and School of Life Sciences, Anhui Agricultural University, Hefei, China. CAS Key Laboratory of Pathogenic Microbiology and Immunology; Institute of Microbiology, Chinese Academy of Sciences; Beijing China Department of Radiation Oncology, University of Texas-MD Anderson Cancer Center, Houston, TX, USA. School of Environment and Guangdong Key Laboratory of Environmental Pollution and Health, Jinan University, Guangzhou 510632, China The State Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, People’s Republic of China; Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Weijin Road No. 94, Nankai District, Tianjin 300071, People’s Republic of China Division of Cardiovascular Surgery The Hospital for Sick Children Toronto Ontario Canada; Department of Surgery University of Toronto Toronto Ontario Canada National Clinical Research Center of Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China The Alabama Center for Paper and Bioresource Engineering; Auburn University; USA Photosynthesis Research Center, Key Laboratory of Photobiology, Institute of Botany, Chinese Academy of Sciences, Beijing 100093, China; Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, 190 Kaiyuan Avenue, Guangzhou 510530, China Center for Microsystem Integration, North University of China, Taiyuan 030051, China; School of Instrument and Intelligent Future Technology, North University of China, Taiyuan 030051, China; Academy for Advanced Interdisciplinary Research, North University of China, Taiyuan 030051, China; School of Instrument and Electronics, North University of China, Taiyuan 030051, China Department of Anesthesiology Zunyi Medical University Zunyi Guizhou China Key Laboratory of Horticultural Plant Biology (Ministry of Education), College of Horticulture and Forestry Sciences, Huazhong Agricultural University, Wuhan 430070, People’s Republic of China; Key Laboratory of Urban Agriculture in Central China (Ministry of Agriculture), Huazhong Agricultural University, Wuhan 430070, People’s Republic of China University of Arizona Health Sciences Center, Tucson, Arizona; and Department of Emergency, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, Hainan 570311, P.R. China State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China College of Pharmacy, Southwest Minzu University, No.16 South 4th Section, 1st Ring Road, Chengdu, Sichuan 610041, PR China Department of Tumor Surgery, The 1st Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui, China (mainland) Capital Medical University,Beijing Friendship Hospital,Department of Radiology,Beijing,China Electron Microscopy Centre Harbin Medical University China Division of Cardiology, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada State Key Laboratory of Respiratory Disease, The First Affiliated Hospital, Guangzhou Medical College, Guangzhou, Guangdong, China School of Chemistry Monash University Clayton Victoria 3800 Australia; State Key Laboratory of High-efficiency Coal Utilization and Green Chemical Engineering College of Chemistry and Chemical Engineering Ningxia University Yinchuan Ningxia 750021 P. R. China Key Laboratory for Organic Electronics and Information Displays & Jiangsu Key Laboratory for Biosensors, Institute of Advanced Materials (IAM), Jiangsu National Synergistic Innovation Center for Advanced Materials (SICAM), Nanjing University of Posts & Telecommunications, 9 Wenyuan Road, Nanjing 210023, China Life Science and Technology Center China National Seed Group Co., Ltd Wuhan China College of Marine Life Science; Ocean University of China; Qingdao 266003; China National Clinical Research Center of Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, 167 Beilishi Road, Beijing, China State Key Laboratory of Brain and Cognitive Science, Institute of Psychology, Chinese Academy of Sciences, Graduate School of Chinese Academy of Sciences Liaoning Key Laboratory of Diabetic Cognitive and Perceptive Dysfunction, Jinzhou Medical University, Jinzhou, China; Department of Anatomy, College of Basic Medical Sciences, China Medical University, Shenyang, China National Clinical Research Center for Cardiovascular Diseases, NHC Key Laboratory of Clinical Research for Cardiovascular Medications, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, National Center for Cardiovascular Diseases Department of Chemistry, Rutgers University, Camden, New Jersey 08102 Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125; National Center for Clinical Laboratories, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital/National Center of Gerontology , Beijing , P.R. China; National Center for Clinical Laboratories, Chinese Academy of Medical Sciences & Peking Union Medical College , Beijing , P.R. China; Beijing Engineering Research Center of Laboratory Medicine, Beijing Hospital , Beijing , P.R. China Department of Internal Medicine, Center for Health Services Research University of Kentucky Lexington Kentucky College of Chemical and Material Engineering, Chaohu University, Hefei, Anhui 230009, People’s Republic of China; Anhui Engineering Research Center for High Efficiency Intelligent Photovoltaic Module, Chaohu University, Hefei, Anhui 230009, People’s Republic of China CAS Key Laboratory of Tropical Plant Resources and Sustainable Use , Yunnan Key Laboratory of Crop Wild Relatives Omics, Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences, Kunming 650223 , China Research Center for Marine Drugs, State Key Laboratory of Oncogene and Related Genes, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China; Biotech Research Institute, Shanghai Academy of Agricultural Sciences, Shanghai Key Laboratory of Agricultural Genetics and Breeding, Shanghai, 201106, China Department of Endocrinology and Metabolism, Department of Guideline and Rapid Recommendation, Cochrane China Center, MAGIC China Center, Chinese Evidence-Based Medicine Center, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, China Center for Health Services Research (CHSR), University of Kentucky College of Medicine, Lexington, Kentucky, USA. Division of Health Policy and Economics, Department of Population Health Sciences, Weill Cornell Medical College, New York, New York State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200032, P.R. China Authors' Affiliations: 1Karmanos Cancer Institute, Wayne State University, Detroit, Michigan and 2Department of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai, China 1Prostate Cancer Discovery and Development Program, Thomas Jefferson University, Philadelphia, Pennsylvania. Department of Population Health Sciences Weill Cornell Medical College Cornell University New York New York USA Key Laboratory of Automobile Materials Ministry of Education School of Materials Science and Engineering Jilin Provincial International Cooperation Key Laboratory of High‐Efficiency Clean Energy Materials Jilin University Changchun 130012 China The State Key Laboratory and Institute of Elemento-Organic Chemistry; Nankai University; Collaborative Innovation Center of Chemical Science and Engineering (Tianjin); Tianjin, China Department of Pathology and Centre of Electron Microscope, Faculty of Basic Science, Harbin Medical University, Harbin, China; Laboratory Medicine and Pathology, Faculty of Medicine & Dentistry, University of Alberta, Edmonton, Canada The University of Texas MD Anderson Cancer Center, Houston, Texas, USA School of Pharmacy and Chemistry, Dali University, Dali, Yunnan 671000, P.R. China Department of Chemistry, Washington University in St. Louis, St. Louis, Missouri 63130-4889, United States Bone and Joint Research Center, The First Affiliated Hospital, Frontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an 710061, China; Department of Orthopaedics, Alpert Medical School/Rhode Island Hospital, Brown University, Providence, RI 02903, USA Beijing Key Laboratory for Pediatric Otolaryngology, Head and Neck Science, Department of Otolaryngology Head and Neck Surgery, Beijing Pediatric Research Institute, Beijing Children’s Hospital, Capital Medical University, Beijing, China Department of Allergy and Clinical Immunology, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University Guangzhou China Department of Virology State Key Laboratory of Pathogens and Biosecurity Beijing Institute of Microbiology and Epidemiology Beijing PR China Northeast Institute of Geography and Agricultural Ecology, Chinese Academy of Sciences, Changchun 130012, China. lijing806521@hotmail.com Center for Molecular Recognition, Columbia University, New York, NY 10032; and Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA 22908 Hebei Shenghong Environmental Technology Co., Ltd., Chengde 067000, China. Department of Neurology, Beijing Tiantan Hospital Capital Medical University Beijing China Organic Chemistry and Catalysis Debye Institute for Nanomaterials Science Utrecht University Universiteitsweg 99 Utrecht 3584CG The Netherlands Department of Cardiothoracic Surgery, University Medical Center Regensburg, Regensburg, Germany State Key Laboratory of Bioelectronics; Jiangsu Key Laboratory for Biomaterials and Devices; School of Biological Sciences and Medical Engineering; Southeast University; Nanjing 210096 Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, New Jersey 08854, and Department of Physics, University of Arkansas, Fayetteville, Arkansas 72701 Georgia Tech, School of Industrial and Systems Engineering, Georgia, USA College of Life Science, Institute of Life Science and Green Development, Hebei University, Baoding 071002, China College of Chemistry and Chemical Engineering, North Minzu University, Yinchuan 750021, Ningxia, China Department of Ultrasound, Xijing Hypertrophic Cardiomyopathy Center, Xijing Hospital, Fourth Military Medical University, Xi’an, Shannxi, China Collaborative Innovation Center for Optoelectronic Semiconductors, Efficient Devices, Pen-Tung Sah Institute of Micro-Nano Science, Technology, Xiamen University, Xiamen 361005, China H. Milton Stewart School of Industrial and Systems Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854 Peking University School of Stomatology Beijing China Functional Nanomaterials Laboratory, Center for Micro/Nanomaterials and Technology, and Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, China Plant Protection Station of Xinjiang Uygur Autonomous Region , Urumqi 830006 , China Department of Radiology, The First Hospital (Eastern Division) of Jilin University, Changchun, China CAS Key Laboratory of Soft Matter Chemistry, Hefei National Laboratory for Physical Sciences at Microscale and Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, People’s Republic of China Department of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University Department of Breast Surgery, The Central Hospital of Enshi Tujia and Miao Autonomous Prefecture , No. 158 Wuyang Street , Enshi 445000 , Hubei , China Heart Center, Beijing ChaoYang Hospital, Capital Medical University, Beijing, China.; Beijing Key Laboratory of Hypertension, Beijing, China. State Key Laboratory of Chemo/Biosensing and Chemometrics; College of Chemistry and Chemical Engineering; Key Laboratory for Bio-Nanotechnology and Molecular Engineering of Hunan Province, Hunan University; Changsha; China Cancer Research Program Julius L Chambers Biomedical Biotechnology Research Institute, North Carolina Central University Durham NC USA; Department of Thoracic Surgery Ningxia Medical University General Hospital Yinchuan PR China From the Division of Cardiology, Xuanwu Hospital Capital Medical University, Beijing, China (J.L., Q.H.); Division of Cardiovascular Diseases (C.S.R., Y.M., A.C., J.H., M.R.B., D.R.H., J.F.B., A.L.), Division of General Internal Medicine (M.Y.E.), Biomedical Statistics (R.J.L.), and Division of Nephrology and Hypertension (L.O.L.), Mayo Clinic, Rochester, MN; Cardiovascular Center, Cardiology, University Hospital Zurich, Zurich, Switzerland (A.J.F.); and Department of Preventive Medicine, College of... Department of Pharmacy; Shanghai Children Hospital; Shanghai Jiao Tong University; Shanghai; China National Clinical Research Center of Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China; NHC Key Laboratory of Clinical Research for Cardiovascular Medications, Beijing, People’s Republic of China National Center for Drug Screening, CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China State Key Laboratory of Petroleum Resources and Engineering in China, University of Petroleum at Beijing, Beijing 102249, P. R. China; Chemical and Petroleum Engineering, University of Calgary, Calgary, Alberta T2N1N4, Canada State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Shandong Eye Institute, Shandong First Medical University & Shandong Academy of Medical Sciences, Qingdao, China Department of Breast Internal Medicine, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan 410013, P.R. China Pen-Tung Sah Institute of Micro-Nano Science and Technology, Xiamen University, Xiamen 361005, China Department of Diagnostic Radiology National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China Department of Radiology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin, 130022, China Department of Anesthesiology, Honghui Hospital, Xi’an Jiaotong University, Xi’an, Shannxi, China Office of Laboratory Management, Chinese Center for Disease Control and Prevention, Beijing 102206, China. Department of Respiratory Diseases, Shenzhen Children’s Hospital, No. 7019, Yitian Road, Futian District, Shenzhen 518026, China Internal Medicine-Carddiovarscular Department, Tianyou Hospital Affiliated to Wuhan University of Science and Technology No. 9 Tujialing, Wuchang District, Wuhan 430064, Hubei, China. Tianjin Key Laboratory of Food Biotechnology Tianjin University of Commerce Tianjin China Department of Pediatrics, Second Hospital of Jiaotong University, Xi' an 710004, China. Department of Hematology, Zhongshan Hospital, Fudan University, Shanghai 200032, China Department of Obstetrics, Gansu Provincial Maternity and Child-care Hospital, Lanzhou, China Merck & Co., Inc. Kenilworth NJ USA From the Multidisciplinary Cardiovascular Research Centre (L.M., N.K.M., P.T., J.L., N.H., K.E.P., D.J.B.), Faculty of Biological Sciences (L.M., N.K.M., P.T., J.L., N.H., D.J.B.), Faculty of Medicine and Health (M.S.G., K.E.P., D.J.B.), University of Leeds, Leeds, United Kingdom; and Leeds Teaching Hospitals, General Infirmary, Leeds, United Kingdom (D.B., D.O.). Obstetric Department, The Second Hospital of Tianjin Medical University, Tianjin, China Department of Bioinformatics, Center for Translational Medicine Second Military Medical University Shanghai 200433 China CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China; Department of Chemistry; Durham University; Durham DH1 3LE; UK Institute of Environmental Science, Department of Chemistry, Shanxi University, Taiyuan 030006, China Department of Hematology, Hebei Province Chinese Medicine Hospital, Shijiazhuang, Hebei, China (mainland) State Key Laboratory of Coordination Chemistry School of Chemistry and Chemical Engineering Collaborative Innovation Center of Advanced Microstructures Nanjing University Nanjing 210023 China Key Laboratory for Petroleum Engineering of the Ministry of Education, China University of Petroleum, Beijing 102249, China Division of Cardiology, Xuanwu Hospital Capital Medical University, Beijing, China Department of Applied Chemistry, China Agricultural University, Beijing 100193, People’s Republic of China Department of Allergy and Clinical Immunology Guangzhou Institute of Respiratory Health State Key Laboratory of Respiratory Disease The First Affiliated Hospital of Guangzhou Medical University Guangzhou China; People's Hospital of Yangjiang Yangjiang China; Guangdong Provincial Key Laboratory of Allergy and Clinical Immunology Guangzhou Medical University Guangzhou China Department of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University Guangzhou, Guangdong Province 510515, China. Department of Urological Tumors, Tumor Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510095, China. State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Collaborative Innovation Center of Advanced Microstructures, Nanjing University, Nanjing 210093, China Department of Food and Nutrition, Hallym University, Chuncheon, Kangwon-do 200-702, South Korea Citrus Research Institute, Southwest University, Chongqing 400712, China; Quality Supervision and Testing Center for Citrus and Seedling, Ministry of Agriculture and Rural Affairs, Chongqing 400712, China; Key Laboratory of Quality and Safety Control of Citrus Fruits, Ministry of Agriculture and Rural Affairs, Chongqing 400712, China; Laboratory of Quality and Safety Risk Assessment for Citrus Products, Ministry of Agriculture and Rural Affairs, Chongqing 400712, China; National Citrus Engineering Research Center, Chongqing 400712, China Department of Oncology Shanghai University Affiliated Mengchao Cancer Hospital Shanghai China State Key Laboratory of Polymer Chemistry and Physics Changchun Institute of Applied Chemistry Chinese Academy of Sciences 5625 Renmin Street Changchun Jilin 130022 P. R. China Institute of Basic Medical Sciences and School of Basic Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China. Shenzhen Key Laboratory of Interfacial Science and Engineering of Materials, State Environmental Protection Key Laboratory of Integrated Surface Water-Groundwater Pollution Control, Guangdong Provincial Key Laboratory of Soil and Groundwater Pollution Control, School of Environmental Science and Engineering, Southern University of Science and Technology, Shenzhen 518055, P. R. China Center for Translational Medicine the First Affiliated Hospital of Xi'an Jiaotong University Xi'an 710061 P.R. China; Key Laboratory for Tumor Precision Medicine of Shaanxi Province the First Affiliated Hospital of Xi'an Jiaotong University Xi'an 710061 P.R. China Key Laboratory of Pulsed Power Technology, IFP, CAEP , Mianyang 621900, China Department of Acupuncture, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430020. Departments of 1Radiology and Medical Imaging,; School of Chemical Engineering and Technology, Tianjin University, Tianjin, China Department of Nephrology, Affiliated Hospital of Hebei University, Baoding, Hebei 071000, P.R. China CAS Center for Excellence in Nanoscience Beijing Key Laboratory of Micro‐Nano Energy and Sensor Beijing Institute of Nanoenergy and Nanosystems Chinese Academy of Sciences Beijing 101400 P. R. China Beijing EviSkin Inc. Beijing China School of Biomedical Sciences, Faculty of Biological Sciences, University of Leeds, Leeds, United Kingdom Changchun University of Traditional Chinese Medicine School of Pharmacy Changchun 130117,China. School of Materials and Chemistry, University of Shanghai for Science and Technology, No. 334 Jungong Road, Shanghai 200093, China; Public Experiment Center, University of Shanghai for Science and Technology, No. 334 Jungong Road, Shanghai 200093, China State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China; Department of Pediatric Dentistry, West China Hospital of Stomatology, Sichuan University, Chengdu, China Department of Gerontology, General Hospital of Air Force, Beijing 100036, China. lijingzw@sina.com a New Materials Research Institute of Shandong Academy of Sciences , Jinan , People's Republic of China Department of Neurology First Hospital of Jilin University Changchun China; Department of Neurological Surgery and Brain and Mind Research Institute Weill Cornell Medicine, Cornell University, New York‐Presbyterian Hospital New York New York USA From Department of Physiology and Biophysics, University of Washington, Seattle. Department of Military Preventive Medicine The fourth military Medical University Xi'an China College of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang, PR China Department of Economic Plants and Biotechnology Yunnan Key Laboratory for Wild Plant Resources Kunming Institute of Botany the Chinese Academy of Sciences Kunming 650201 China Key Laboratory of Resource Biology and Biotechnology in Western China (Northwest University) Ministry of Education, School of Life Sciences, Northwest University Xi’an, Shaanxi China Real World Solutions, Iqvia, Durham, North Carolina Department of Gynecological Oncology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China. Department of Biochemistry, University of Toronto, Toronto, ON M5S 1A8, Canada. Department of Oncology, YangZhou No.1 People's Hospital, The Second Clinical School of Yangzhou University, Yangzhou, Jiangsu Province, China Core Genomic Facility Beijing Institute of Genomics Chinese Academy of Sciences 100101 Beijing China Department of Spine Surgery, The Second Xiangya Hospital, Central South University, Changsha, China; State Key Laboratory of Reproductive Medicine, Institute of Toxicology, Nanjing Medical University, Nanjing, China; Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, China; Department of Public Health, Xuzhou Medical University, Xuzhou, Jiangsu, China School of Information and Communication Engineering, The North University of China, Taiyuan 030051, China. lijingnuc@163.com College of Integrated Chinese and Western Medicine, Hebei Medical University, Shijiazhuang, Hebei 050011, P.R. China Department of Molecular and Cellular Physiology, University of Cincinnati College of Medicine, Cincinnati, Ohio; Duke University, Durham, North Carolina. Anhui Key Laboratory of Tissue Transplantation, Bengbu Medical College, Bengbu, Anhui; Department of Clinical Laboratory, First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui School of Pharmacy, Hebei University of Chinese Medicine, Shijiazhuang, China; Hebei Higher Education Institute Applied Technology Research Center on TCM Formula Preparation, Shijiazhuang, China Institute of computational biology, College of Intelligence and Computing, Tianjin University, Tianjin, China From the Division of Cardiology, Shanghai Sixth Hospital, Shanghai Jiao Tong University School of Medicine, State Key Discipline Division, Shanghai, People's Republic of China (M.W., P.X., S.L., J.T., Y.L., M.L., J.L., W.Z.); Division of Cardiology, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada (J.L., W.Z., A.N.R.). National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention; State Key Laboratory for Infectious Disease Prevention and Control, Beijing, People's Republic of China School of Food and Biological Engineering Jiangsu University Zhenjiang China Affiliated Children's Hospital, Capital Institute of Pediatrics, Beijing, China. Department of Ophthalmology, Yangpu Hospital, School of Medicine, Tongji University, Shanghai, China. Bioinformatics and Computational Biology Program, Iowa State University , Ames, IA, USA; Genetics, Development, and Cell Biology, Iowa State University , Ames, IA, USA Department of Pharmacology and ‡Cancer Therapy & Research Center, University of Texas Health Science Center at San Antonio, Texas 78229, United States State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China Industrial Engineering, Arizona State University, Tempe, AZ, USA School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, China; The Clinical Metabolomics Center, China Pharmaceutical University, Nanjing 210009, China Department of Pediatrics Beijing Tongren Hospital Capital Medical University Beijing China Citrus Research Institute Southwest University Chongqing P. R. China; Laboratory of Citrus Quality and Safety Risk Assessment for Citrus Products Ministry of Agriculture and Rural Affairs Chongqing P. R. China; Quality Supervision and Testing Center for Citrus and Seedling Ministry of Agriculture and Rural Affairs Chongqing P. R. China College of Electronic Information Engineering, Shandong University of Science and Technology, Qingdao 266590, China Department of Nephrology Affiliated Hospital of Hebei University Baoding Hebei China Institut Néel-CNRS and Université Grenoble-Alpes, F-38042 Grenoble, France; CEA, IRIG, MEM-L_Sim, Université Grenoble-Alpes, F-38000 Grenoble, France Department of Microbiology, University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania, USA School of Public Health Weifang Medical University Weifang People's Republic of China Electrocardiogram Room, Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, Shandong 264000, P.R. China Radiology Department, Southwest Hospital Army Medical University Chongqing China School of Chemistry and Chemical Engineering Southeast University Nanjing 211189 China Department of Biostatistics Indiana University Richard M. Fairbanks School of Public Health Indianapolis Indiana USA 3School of Medicine, Tsinghua University, Beijing, China. Molecular Biology Laboratory. Department of Radiology, The First Medical Centre, Chinese PLA General Hospital, Beijing, China Department of Hematology, First Hospital of Xi'an Jiaotong University, Xi'an 710061, China. anlj1676@eyou.com Department of Neurology, General Hospital of Jinan Military Command of Chinese PLA, Jinan 250031, Shandong Province, China. Environment Research Institute, Shandong University, Qingdao 266237, China Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China; University of Chinese Academy of Sciences, Beijing 100049, China Shenyang National Laboratory for Materials Science Institute of Metal Research Chinese Academy of Sciences No. 72 Wenhua Road Shenhe District Shenyang 110016 China the State Key Laboratory and Institute of Elemento-Organic Chemistry College of Chemistry Nankai University Tianjin 300071 P. R. China; Collaborative Innovation Center of Chemical Science and Engineering (Tianjin) Weijin Road 94#, Nankai District Tianjin 300071 China Department of Chemistry and Chemical Biology, Rutgers University, 610 Taylor Road, Piscataway, New Jersey 08854, National Energy Technology Laboratory, United States Department of Energy, P.O. Box 10940, Pittsburgh, Pennsylvania 15236, and Department of Chemical Engineering, University of Pittsburgh, Pittsburgh, Pennsylvania 15261 Laboratory of Stem Cells and Tissue Engineering, College of Basic Medical, Chongqing Medical University, Chongqing 400016, China Key Laboratory for Polymeric Composite and Functional Materials of Ministry of Education School of Chemistry Sun Yat‐sen University Guangzhou Guangdong Province 510275 China Traditional Chinese Medicine Department, The Sixth Medical Center of Chinese PLA General Hospital, Beijing, China Xiamen University Department of Electronic Science, Fujian Provincial Key Laboratory of Plasma and Magnetic Resonance, State Key Laboratory of Physical Chemistry of Solid Surfaces, , Xiamen 361005, China Department of Traditional Chinese Medicine, Children' Hospital of Kaifeng, Kaifeng 475000, China. Department of Pediatrics, Beijing Tongren Hospital Capital Medical University, Beijing, People’s Republic of China Blood Group Reference Laboratory, Shandong Blood Center, Jinan, Shandong 250014, P.R. China State Key Laboratory of Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China Department of Foot Ankle Surgery, the Pu'ai Hospital Affiliated to Huazhong Science and Technology University, Wuhan 430030, Hubei, China. likun2121@yahoo.com.cn Department of Pharmacy, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China Department of Hepatobiliary Surgery of Xinqiao Hospital, Third Military Medical University, Chongqing, PR China. xqyylijing@163.net Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China Key Laboratory of Human Disease Comparative Medicine, NHFPC, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences & Comparative Medical Center, Peking Union Medical College, Building 5, Panjiayuan Nanli, Chaoyang District, Beijing 100021, China; School of Life Science and Technology, China Pharmaceutical University, Nanjing, Jiangsu 210009, P. R. China Weldon School of Biomedical Engineering; Purdue University; West Lafayette; USA 2Department of Translational Chemistry, Eisai AiM Institute, Eisai Inc., Andover, Massachusetts. a Departments of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA Institute of Plant Protection, Chinese Academy of Agricultural Sciences Key Laboratory of Pesticide Chemistry and Application Ministry of Agriculture Beijing P. R. China Department of Nursing, Tianjin Medical College, Tianjin 300222, P.R. China Laboratory Department, Capital Institute of Pediatrics, Beijing 100020, PR China Biomedical Center, School of Life Sciences, Sun Yat-sen University, Guangzhou, China; Department of Genetics and Biochemistry, Clemson University, USA West China Hospital, Chengdu, China Department of Cardiothoracic Surgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, P.R. China Department of Anesthesiology, General Hospital of Tianjin Medical University, Tianjin 300052, China Department of Food Science and Technology , College of Light Industry and Food Engineering, Nanjing Forestry University, Longpan road, Xuanwu district, Nanjing 210037 , China Department of Orthopaedic, First Affiliated Hospital, School of Medicine, Shihezi University, ShiHeZi, Xinjiang, China Hematology Department, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330000, P.R. China Department of Biotherapy, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, China. Nursing College of Beihua University, Jilin Province, China. Center for Immunochemistry, Veterans Administration Medical Center,2 San Francisco, California National Clinical Research Center of Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. Tianjin Eye Hospital, Tianjin Key lab of Ophthalmology and Visual Science, Tianjin Eye Institute, Tianjin, China; Nankai University Affiliated Eye Hospital, Tianjin, China; Clinical College of Ophthalmology, Tianjin Medical University, Tianjin, China College of Pharmacy, 3rd Military Medical University, Chongqing, China Center for Advanced Resuscitation Medicine, Department of Emergency Medicine University of Illinois at Chicago Chicago Illinois USA; Center for Cardiovascular Research University of Illinois at Chicago Chicago Illinois USA Department of Civil and Environmental Engineering, University of Wisconsin - Madison Madison, Wisconsin 53706, United States Central South University Institute of Food Science and Engineering Jinzhou Medical University Jinzhou P.R. China Department of Gynecology, Shenzhen Second People’s Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen, Guangdong, China; Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, National-Regional Key Technology Engineering Laboratory for Medical Ultrasound, School of Biomedical Engineering, Shenzhen University Medical School, Shenzhen, Guangdong, China Beijing Key Laboratory for Bioengineering and Sensing Technology, Research Center for Bioengineering and Sensing Technology, School of Chemistry and Biological Engineering, University of Science and Technology Beijing, Beijing 100083, P. R. China 1Oncology and Departments of State Key Laboratory of Silicon Materials; School of Materials Science and Engineering; Zhejiang University; Hangzhou 310027; People's Republic of China Department of Neurology The Third Affiliated Hospital of Sun Yat‐Sen University Guangzhou Guangdong Province China Authors' Affiliation: Karmanos Cancer Institute, Wayne State University, Detroit, Michigan Department of Genetics and Biochemistry, Clemson University, Clemson, South Carolina, USA Department of Laboratory Medicine, Ningbo Medical Center, Lihuili Hospital Ningbo University Ningbo China School of Environmental Studies, China University of Geosciences, Wuhan 430074, China. Department of Medical Biochemistry and Biophysics, Karolinska Institutet, S-171 77 Stockholm, Sweden, Division of Pulmonary Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229-3039, Division of Newborn Medicine, Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri 63110, Endotoxin Group, UMR-8619 of the National Center for Scientific Research, University of Paris-Sud, 91405 Orsay, France, Division of Neonatology, Department of Pediatrics,... Department of Liver Disease, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen, Guangdong 518033, P.R. China Center for Reproductive Medicine, Cheeloo College of Medicine, Shandong University; The Key Laboratory of Reproductive Endocrinology of Ministry of Education; National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Jinan, Shandong Province, 250001,China Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, New Jersey 08854, United States Department of Thoracic Surgery, The Second Hospital of Hebei Medical University, Shijiazhuang, China; Graduate school of Hebei Medical University, Shijiazhuang, China Department of Neurology, Beijing Tiantan Hospital Capital Medical University Beijing China; China National Clinical Research Center for Neurological Diseases Beijing Tiantan Hospital, Capital Medical University Beijing China Safety, Environment, and Technology Supervision Research, Institute of PetroChina Southwest Oil & Gasfield Company, Chengdu, People’s Republic of China Department of Anesthesiology, Rutgers, New Jersey Medical School, Newark, NJ, USA. State Key Laboratory of Natural Medicines, Department of Pharmaceutics, China Pharmaceutical University, Nanjing, China Upper Airway Research Laboratory, Hackensack Meridian Health Center for Discovery and Innovation, Nutley, NJ 07110, USA Hoffmann Institute of Advanced Materials, Shenzhen Polytechnic 7098 Liuxian Blvd., Nanshan District Shenzhen 518055 P. R. China; Department of Chemistry and Chemical Biology Rutgers University 123 Bevier Road Piscataway NJ 08854 USA Harbin Medical University; Wenzhou Medical University Harvard–MIT Division of Health Sciences and Technology, Koch Institute for Integrative Cancer Research, Singapore–MIT Alliance for Research and Technology, Department of Biological Engineering, Massachusetts Institute of Technology (MIT), 77 Massachusetts Avenue, Cambridge, MA 02139, U.S.A. School of Life Sciences and Technology Xinxiang Medical University Xinxiang Henan China School of Chemistry and Chemical Engineering; Xi'an University of Arts and Sciences; Xi'an, China Department of Epidemiology, School of Public Health Fudan University, and The Key Laboratory of Public Health Safety of Ministry of Education Shanghai China State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Collaborative Innovation Center of Advanced Microstructures, Nanjing University, Nanjing 210023, People’s Republic of China National Institute for Materials Science, 1-2-1 Sengen, Tsukuba, Ibaraki 305-0047, Japan State Key Laboratory of Marine Pollution (SKLMP), and Department of Chemistry, City University of Hong Kong, Hong Kong SAR, China; Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai), Zhuhai 519080, China; Research Centre for the Oceans and Human Health, City University of Hong Kong Shenzhen Research Institute, Shenzhen 518057, China State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Centre Sun Yat‐sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Centre for Ocular Diseases Guangzhou China Department of Biological and Environmental Engineering, Hefei University, Hefei, China Department of Clinical Oncology The First Affiliated Hospital Zhengzhou University Zhengzhou 450052 P. R. China College of Agronomy, Anhui Agricultural University, No.130 Changjiangxilu Hefei 230036 P.R. China Centre for Advanced 2D Materials, National University of Singapore, 117543, Singapore Department of Immunobiology, Institute of Tissue Transplantation and Immunology, Jinan University, Guangzhou, China School of Chemistry and Chemical Engineering, Jiangxi Provincial Key Laboratory of Functional Molecular Materials Chemistry, Jiangxi University of Science and Technology, Ganzhou, Jiangxi Province 341000, P.R. China Collaborative Innovation Center for Optoelectronic Semiconductors and Efficient Devices Pen‐Tung Sah Institute of Micro‐Nano Science and Technology/Department of Physics Xiamen University Xiamen 361005 China From the Center for Outcomes Research and Evaluation, Yale-New Haven Hospital, CT (E.S.S., Y.W., Y.L., X.X., H.M.K.); Section of Cardiovascular Medicine, Department of Internal Medicine (E.S.S., Y.W., H.M.K.), Department of Obstetrics and Gynecology and Reproductive Sciences (X.X.), Yale School of Medicine, New Haven, CT; Harvard Medical School, Boston, MA (A.L.B.); National Center for Cardiovascular Diseases, Fuwai Hospital, Beijing, China (X.W., X.D., J.L., L.J.); Johns Hopkins School of Nursing,... Department of Spine Surgery, The Second Xiangya Hospital, Central South University, Hunan, P.R. China Radiation Oncology, and Key Laboratory of Photochemical Conversion and Optoelectronic Materials Technical Institute of Physics and Chemistry Chinese Academy of Sciences Beijing 100190 P. R. China National Clinical Research Center for Oral Diseases State Key Laboratory of Military Stomatology Shaanxi Key Laboratory of Stomatology Department of Prosthodontics School of Stomatology The Fourth Military Medical University Xi'an Shaanxi P. R. China Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University College of Veterinary Medicine, Yangzhou, Jiangsu, China Institute for Immunology and School of Medicine, Tsinghua University, Beijing 100084, P.R. China College of Chemistry and Chemical Engineering, Yantai University, Yantai 264005, Shandong, China Department of Biological and Environmental Sciences, Genetics, University of Helsinki, 00014 Helsinki, Finland Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China; Beijing Eye Institute, Beijing Ophthalmology and Visual Science Key Laboratory, Beijing, China Key Laboratory for Advanced Materials and Institute of Fine Chemicals, East China University of Science and Technology, Shanghai 200237, People’s Republic of China Department of Surgery, The People's Hospital of Zhangqiu Area, Jinan 250200, P.R. China Endocrinology Department, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian 350005, P.R. China Coordination Chemistry Institute; State Key Laboratory of Coordination Chemistry; Nanjing University; Nanjing 210093; P.R. China School of Biology and Biological Engineering, South China University of Technology, Guangzhou 510006, P. R. China Key Laboratory of Drug Quality Control and Pharmacovigilance (China Pharmaceutical University), Ministry of Education; Center for Instrumental Analysis, China Pharmaceutical University IQVIA, Real-World Solutions, Durham, North Carolina (J.L., J.B.) Institute of Crop Science, Chinese Academy of Agricultural Sciences First Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China (mainland) State Key Laboratory Breeding Base for Zhejiang Sustainable Pest and Disease Control, Key Laboratory of Plant Protection and Biotechnology, Ministry of Agriculture, and Zhejiang Provincial Key Laboratory of Plant Virology, Institute of Virology and Biotechnology, Zhejiang Academy of Agricultural Sciences, Hangzhou, China Department of Urology, Shaanxi Provincial People’s Hospital, Xi’an, China Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA Center for Applied Chemical Research, Frontier Institute of Science and Technology, and State Key Laboratory for Mechanical Behavior of Materials, Xi’an Jiaotong University, Xi’an 710049, China Department of Gynecology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510630, China Department of Chemistry, Graduate School of Science Tohoku University Aza Aramaki Aoba-ku Sendai 980-8578 Japan Shanghai Center for Plant Stress Biology and Center for Excellence in Molecular Plant Sciences, Chinese Academy of Sciences, Shanghai 200032, China; University of Chinese Academy of Sciences, Beijing 100049, China College of Life Sciences, Institute of Life Sciences and Green Development Hebei University Baoding Hebei Province 071002 China Hoffmann Institute of Advanced Materials Shenzhen Polytechnic 7098 Liuxian Blvd., Nanshan District Shenzhen Guangdong 518055 P. R. China; Department of Chemistry and Chemical Biology Rutgers University 123 Bevier Road Piscataway NJ 08854 USA Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China Department of Oncology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450000, China Department of Economic Plants and Biotechnology Yunnan Key Laboratory for Wild Plant Resources Kunming Institute of Botany Chinese Academy of Sciences Kunming 650201 China Laboratory of Stem Cell and Tissue Engineering, Department of Histology and Embryology, Chongqing Medical University Chongqing 400016, China. Department of Genetics and Biochemistry, Clemson University, South Carolina Experiment Station, 190 Collings Street, Clemson, South Carolina 29634, United States Nursing College, Xi'an Medical University, Xi'an 710021, China. Bone and Joint Research Center The First Affiliated Hospital and Frontier Institute of Science and Technology Xi'an JiaoTong University Xi'an China Heart Center & Beijing Key Laboratory of Hypertension, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China Department of Hematology and Oncology, Wake Forest School of Medicine, Winston-Salem, NC, USA National Clinical Research Center of Cardiovascular Diseases, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China School of Biological Science and Medical Engineering, Beihang University, Beijing, China; Department of Integrated Systems Engineering, The Ohio State University, Columbus, OH, USA Center of Excellence in Tissue Engineering, Chinese Academy of Medical Sciences and Peking Union Medical College, Institute of Basic Medical Sciences and School of Basic Medicine, Beijing, People's Republic of China. Department of Pathology Dalian Medical University Dalian China Key Laboratory of Luminescent and Real-Time Analytical Chemistry, Ministry of Education, School of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, P. R. China Department of Allergy and Clinical Immunology Guangzhou Institute of Respiratory Health The First Hospital Guangzhou Medical University Guangzhou China Department of Physiology Shandong University School of Medicine Jinan China Department of Emergency Medicine, University of Illinois Hospital and Health Sciences System, Chicago, IL, USA Department of Orthopaedics, Xi Jing Hospital Affiliated to the Air Force Medical University, Shaanxi, China Hainan University, 74629, school of plant protection, Hainan Province, Haikou, No.58, Renmin Avenue, Meilan District, Haikou, Hainan, China, 570288, ; MIIT Key Laboratory of Advanced Display Materials and Devices School of Environmental and Biological Engineering Nanjing University of Science and Technology Nanjing 210094 P. R. China Neurology Department The First Hospital of Tsinghua University Beijing China Department of Pediatrics, Steele Children's Research Center, University of Arizona, Tucson, Arizona; and Jing Li, Weill Cornell Medical College. School of Chemical and Biomolecular Engineering The University of Sydney Darlington New South Wales 2006 Australia Clinical Laboratory The First Affiliated Hospital of Chengdu Medical College Chengdu Sichuan China Department of Dermatology, Northwest Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi 710004, P.R. China Key Laboratory of the Ministry of Education for Coastal and Wetland Ecosystems, College of the Environment and Ecology, Xiamen University , South Xiangan Road, Xiangan District, Xiamen, Fujian 361102 , China Department of Anatomy, Academy of Basic Medicine, Jining Medical University, Shandong, China; alexlijing800912@yahoo.com. Department of Anesthesiology; Rutgers, New Jersey Medical School; Newark New Jersey The Key Laboratory of Myocardial Ischemia, Harbin Medical University, Ministry of Education, Harbin 150086, China; Department of Clinical Pharmacy, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China Department of Physiology, Guangxi Medical University, Nanning 530021, China; Center of Translational Medicine, Guangxi Medical University, Nanning 530021, China First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China Basic Medical College,Xinjiang Medical University,Urumqi,China †Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Vanderbilt University Medical Center, Nashville, TN;; ‡Vanderbilt Institute of Infection, Immunity, and Inflammation, Vanderbilt University Medical Center, Nashville, TN; Department of Pharmacy The First Affiliated Hospital of Xinjiang Medical University Urumqi Xinjiang China Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, China Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston Shanghai Fengxian District Central Hospital and East China Normal University Joint Center for Translational Medicine, Department of Orthopaedics, Shanghai Fengxian District Central Hospital Shanghai China School of Chemistry and Chemical Engineering, Yancheng Institute of Technology, Yancheng 224051, P. R. China Key Laboratory of Eco-textiles, Ministry of Education, Jiangnan University, Wuxi 214122, P.R. China Anqing Medical College; Anqing 246052; People's Republic of China Department of Cardiology, Gansu Provincial Hospital, Gansu, Lanzhou 730000, P. R. China Department of Orthopedics & Traumatology, Rizhao Hospital of Traditional Chinese Medicine, Rizhao, China Department of Infectious Diseases, Shunde Hospital, Southern Medical University, Shunde District, Guangdong, China, Shunde, Guangdong, China Center for Functional Nanomaterials, Brookhaven National Laboratory, Upton, New York 11973, United States Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, China 1State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 2Karmanos Cancer Institute, Cancer Biology Program, Wayne State University School of Medicine, Detroit, Michigan. Department of Cardiology, Beijing Hospital, Beijing 100730, China. leejingabc@sina.com Xingaoyi Medical Equipment Company Limited, China Department of CyberKnife, Huashan Hospital, Fudan University, Shanghai 201206, China Department of Pulmonary Medicine Beijing University People's Hospital Beijing China Department of Pediatrics and Ben May Institute for Cancer Research, University of Chicago, Chicago, Illinois 60637 State Key Laboratory of Oral Diseases National Clinical Research Center for Oral Diseases West China Hospital of Stomatology Sichuan University Chengdu China; Department of Pediatric Dentistry West China Hospital of Stomatology Sichuan University Chengdu China Key laboratory of Eco-textiles, Jiangnan University, Ministry of Education, Wuxi 214122, China Department of Chemistry, Texas A&M University, College Station, Texas, USA Department of Pharmacy, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266003, P.R. China State Key Laboratory of Heavy Oil Processing and Center for Bioengineering & Biotechnology; China University of Petroleum; Qingdao China National Engineering Research Center for Modernization of Extraction and Separation Process of TCM, Guangzhou 510240, China Department of Healthcare Policy and Research, Weill Cornell Medical College, New York, NY 10065; State Key Laboratory of Coordination Chemistry; School of Chemistry and Chemical Engineering; Collaborative Innovation Center of Advanced Microstructure; Nanjing University; Nanjing 210023 National Clinical Research Center of Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, Peopl Digestive Department, Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning, China Ministry of Education Key Laboratory of Analytical Science for Food Safety and Biology; College of Chemistry; Fuzhou University; Fuzhou; China Department of Ultrasound XiJing Hypertrophic Cardiomyopathy Center XiJing Hospital/AFMU Xi'an Shannxi China tcz9065@hotmail.com Division of Nephrology, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China Department of Cardiology,the Second Affiliated Hospital of Medical College of Zhejiang University Hangzhou 310003,China. Laboratory of Stem Cells and Tissue Engineering, Department of Histology and Embryology, Chongqing Medical University, Chongqing 400016, P.R. China State Key Laboratory of Elemento‐Organic Chemistry, College of Chemistry Nankai University Tianjin 300071 People's Republic of China Department of Epidemiology and Biostatistics School of Public Health Tianjin Medical University Tianjin China Key Laboratory of Jianghuai Agricultural Product Fine Processing and Resource Utilization Ministry of Agriculture and Rural Affairs, Anhui Engineering Laboratory for Agro-Products Processing, Food Processing Research Institute, College of Tea & Food Science and Technology, Anhui Agricultural University, Hefei 230036, China Program in Cellular and Molecular Medicine, Boston Children’s Hospital, Boston, MA 02115; Department of Endocrine and Metabolism, the Second Affiliated Hospital, Sun Yat-sen University, Guangzhou 510120, China. Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey Department of Clinical Laboratory, Central Hospital of Panzhihua City, Panzhihua, Sichuan 617067, P. R. China Neonatal Department Chengdu Women’s and Children’s Central Hospital School of Medicine University of Electronic Science and Technology of China Chengdu Sichuan China The first school of clinical medicine, Guangxi of university of Chinese medicine Nanning China Department of BioMolecular Sciences School of Pharmacy University of Mississippi University MS USA; Research Institute of Pharmaceutical Sciences School of Pharmacy University of Mississippi University MS USA Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing 100029, China Life Science College, Southwest Forestry University, Kunming 650224, China. *Corresponding authors, E-mail: lijingcas@163.com. Department of Oral Pathology, Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, China. College of Food Science and Technology; Huazhong Agricultural University; Wuhan 430070; China; Key Laboratory of Environment Correlative Dietology Department of Organic Chemistry, College of Chemistry, Jilin University, 2699 Qianjin Street, Changchun 130012, China College of Mechanical Engineering, Yangzhou University, Yangzhou 225127, China Department of Chemistry State University of New York at Binghamton Binghamton NY 13902 USA Department of Rheumatology and Clinical Immunology, Chinese Academy of Medical Sciences & Peking Union Medical College, National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID) , Ministry of Science & Technology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital (PUMCH), Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education , Beijing , China Department of Pharmacy, Zhongshan Hospital Fudan University Shanghai China College of Food Science Southwest University Chongqing China; Chongqing Key Laboratory of Speciality Food Co‐Built by Sichuan and Chongqing Chongqing China Division of Gastroenterology and Hepatology, Shanghai Institute of Digestive Disease, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China Department of Radiation Oncology Jinling Hospital Medical School of Nanjing University Nanjing China Key Laboratory on Assisted Circulation of Health Ministry, First Affiliated Hospital, Sun Yat-sen University, Guangzhou Guangdong, 510089, P.R.China;School of Biomedical Engineering, Sun Yat-sen University, Guangzhou Guangdong, 510006, P.R.China. Innovation and Practice Center, Changchun University of Chinese Medicine Changchun 130117, China. College of Resources and Environmental Sciences, China Agricultural University, Beijing 100193, China; Beijing Key Laboratory of Biodiversity and Organic Farming, China Agricultural University, Beijing 100193, China College of Plant Protection, Agricultural University of Hebei, Baoding, Hebei, P. R. China School of Agriculture and Biology, Shanghai Jiao Tong University, 800 Dongchuan Road, Minhang District, Shanghai 200240, China H. Milton Stewart School of Industrial and Systems Engineering Georgia Institute of Technology Atlanta GA USA Department of Pathology Central Hospital of Zibo Zibo China School of Medicine and Life Sciences, University of Jinan-Shandong Academy of Medical Sciences, Jinan, China Singapore Eye Research Institute, Singapore Canadian Institutes of Health Research Group in Membrane Biology, Departments of Biochemistry and Medicine, University of Toronto, Toronto, Ontario, Canada M5S 1A8 Department of Nutrition and Food Hygiene, Nanjing Medical University, Nanjing 210029, China. State Key Laboratory of Food Science and Technology, School of Food Science and Technology Nanchang Univ. Nanchang 330047 China School of Chemistry and Chemical Engineering, Yangzhou, University, Yangzhou 225002, China College of Food Science, Southwest University, Chongqing 400715, P.R. China State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences and Neuroscience Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, China 1 State Key Joint Laboratory for Environmental Simulation and Pollution Control, College of Environmental Sciences, Peking University, Beijing 100871, China Clinical Research Academy Peking University Shenzhen Hospital, Peking University Shenzhen Guangdong China; Renal Division Peking University Shenzhen Hospital, Peking University Shenzhen China State Key Laboratory of Coordination Chemistry; School of Chemistry and Chemical Engineering; Collaborative Innovation Center of Advanced Microstructures; Nanjing University; Nanjing 210046 State Key Laboratory of Separation Membranes and Membrane Processes; School of Textiles; Tianjin Polytechnic University; Tianjin 300387; China Beihang University School of Instrumentation Science and Opto-electronics Engineering, , 37 Xueyuan Road, Beijing 100191, China 2Markey Cancer Center, University of Kentucky, Lexington, Kentucky, USA School of Electrical and Control Engineering, Shaanxi University of Science and Technology, Xi'an 710021, China State Key Lab. for Conservation and Utilization of Bio‐Resources in Yunnan, Ministry of Education Key Lab. of Agriculture Biodiversity for Plant Disease Management, Yunnan Agricultural Univ. Kunming 650201 China Northwest Institute of Eco-Environment and Resources, Chinese Academy of Sciences/Key Laboratory of Petroleum Resources Research, Lanzhou, Gansu Province 730000, China School of Industrial and Systems Engineering, Georgia Tech, Atlanta, GA, USA Department of Materials Science and Chemical Engineering, State University of New York at Stony Brook, Stony Brook, New York 11794-2275, United States Department of Social Medicine, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, School of Public Health Soochow University Suzhou China Beijing Tongren Eye Center Beijing Key Laboratory of Ophthalmology and Visual ScienceBeijing Tongren Hospital of Capital Medical University Beijing China School of Chemistry and Chemical Engineering University of Surrey Guildford GU2 7XH UK Medical Center of Ultrasound Lanzhou University Second Hospital Lanzhou Gansu China Department of Burn and Plastic Surgery Shandong Provincial Hospital Affiliated to Shandong First Medical University Jinan China Heart Center & Beijing Key Laboratory of Hypertension Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing People's Republic of China Key Laboratory of Ministry of Education for Genetics, Breeding and Multiple Utilization of Crops, Fujian Agriculture and Forestry University, Fuzhou 350002, China; Fujian Key Laboratory of Crop Breeding for Design, Fujian Agriculture and Forestry University, Fuzhou 350002, China Department of Acupuncture and Moxibustion, the Third Affiliated Hospital of Nanjing University of CM, Nanjing 210001, Jiangsu Province, China. State Key Laboratory of Animal Biotech Breeding, College of Animal Science and Technology, China Agricultural University , Beijing, China Department of Clinical Laboratory, The Affiliated Hospital of Qingdao University, Qingdao, China Radiation Oncology Department of Information, Zhejiang Hospital, Hangzhou, China State Key Laboratory of Crystal Materials, Shandong University, Jinan 250100, P. R. China Wuhan National Laboratory for Optoelectronics, School of Optical and Electronic Information, Huazhong University of Science and Technology, Wuhan 430074, China State Key Laboratory of New Ceramics and Fine Processing School of Materials Science and Engineering Tsinghua University Beijing 100084 China Department of Pulmonary Medicine, People's Hospital, Beijing University, Beijing 100044, China. School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, People's Republic of China Key Laboratory of Green Chemistry & Technology of Ministry of Education, College of Chemistry, Sichuan University, 29 Wangjiang Road, Chengdu 610064, P. R. China School of Pharmacy Anhui University of Chinese Medicine Hefei China College of Landscape and Horticulture, Yunnan Agricultural University, Kunming 650201, China State Key Laboratory of Molecular and Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China. University of Macau Institute of Applied Physics and Materials Engineering CHINA State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, P.R. China State Key Laboratory of Plant Physiology and Biochemistry, College of Biological Sciences, China Agricultural University, Beijing 100193, China Department of Food Nutrition and Safety, Sanda University, Shanghai 201209, China College of Life Engineering, Shenyang Institute of Technology, Fushun Liaoning, China School of Acupuncture Moxibustion and Tuina, Beijing University of Chinese Medicine, Beijing, China College of Chemistry and College of Chemical Engineering Sichuan University Chengdu P. R. China State Key Laboratory of Pollution Control and Resources Reuse College of Environmental Science and Engineering Tongji University Shanghai China Key Laboratory for Special Functional Aggregate Materials of Education Ministry, School of Chemistry and Chemical Engineering, Shandong University, Jinan, 250100, P. R. China College of Chemistry and Chemical Engineering; Yantai University; Yantai; China First Affiliated Hospital of Hunan Normal University Hunan Provincial People's Hospital Changsha China State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Health, National Clinical Centre of Respiratory Disease, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong 510120, P.R. China Department of Infectious Diseases, Research Laboratory of Clinical Virology, Ruijin Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, People’s Republic of China Cell Signaling Technology, 3 Trask Lane, Danvers, MA 01923, U.S.A. Department of Basic Nursing, Tianjin Medical College, Tianjin 300222, P.R. China Department of Immunology, School of Basic Medical, Zhengzhou University, Zhengzhou, China School of Biomedical Sciences, Lo Kwee‐Seong Integrated Biomedical Sciences Building The Chinese University of Hong Kong Hong Kong SAR China †Department of Biological Sciences, Xi’an Jiaotong-Liverpool University, Suzhou 215123, Jiangsu Province, China; School of Materials and Chemical Engineering, Xuzhou University of Technology, Xuzhou 221018, PR China Université Grenoble Alpes, CNRS, Inst NEEL, F-38042 Grenoble, France Jilin Ginseng Academy, Changchun University of Chinese Medicine, Changchun, 130117, China Department of Chemical and Biomolecular Engineering and Minerals, Metals, and Materials Technology Center, Faculty of Engineering, National University of Singapore, 10 Kent Ridge Crescent, Singapore 119260 School of Pharmacy, Guangdong Medical University, Dongguan, China Foshan Graduate School of Northeastern University, No. 2, Zhihui Road, Foshan, China Department of Chemistry, College of Science Shanghai University Shanghai 200444 P. R. China Department of Physiology, Capital Medical University; Department of Allergy and Clinical Immunology, Guangzhou Institute of Respiratory Health, State Key Lab of Respiratory Disease The First Affiliated Hospital of Guangzhou Medical University Guangzhou China Department of Cell Biology and Neurobiology Xuzhou Key Laboratory of Neurobiology, Xuzhou Medical University Xuzhou Jiangsu China Department of Radiology, Jing’an District Center Hospital of Shanghai, Shanghai, 200040, China State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi Key Laboratory of Stomatology Department of Prosthodontics School of Stomatology The Fourth Military Medical University Xi'an 710032 Shaanxi China CAS Key Laboratory of Soft Matter Chemistry and Department of Chemistry; University of Science and Technology of China; Hefei; People's Republic of China Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, Beijing Advanced Innovation Centre for Biomedical Engineering, School of Engineering Medicine, School of Biological Science and Medical Engineering, Beihang University, No.37 Xueyuan Road, Haidian District, Beijing 100083, P. R. China Department of Radiation Oncology, MD Anderson Cancer Center , Houston, Texas , USA Key Laboratory of Bio-resources and Eco-environment of Ministry of Education, College of Life Sciences, Sichuan University , Chengdu 610064 , China Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences,Xi'an Jiaotong University Health Science Center,Xi'an,China; Key Laboratory of Environment and Genes Related to Diseases,Xi'an Jiaotong University, Ministry of Education of China,Beijing,China School of Traditional Chinese Materia Medica Shenyang Pharmaceutical Univ. 110016 Shenyang China Beijing Key Laboratory of Pediatric Hematology Oncology National Key Discipline of Pediatrics Ministry of Education Key Laboratory of Major Diseases in Children Ministry of Education Hematology Oncology Center Beijing Children's Hospital Capital Medical University National Center for Children’s Health Beijing China Division of Nutritional Sciences, Mammalian NutriPhysioGenomics, Department of Animal Sciences, University of Illinois, 1207 West Gregory Drive, Urbana IL61801, USA Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA. Department of Child and Adolescent Health , School of Public Health, , Suzhou, Jiangsu 215123, P.R. China; Medical College of Soochow University , School of Public Health, , Suzhou, Jiangsu 215123, P.R. China Department of Chemistry; Graduate School of Science; Tohoku University; 6-3 Aramaki Aza-Aoba; Aoba-ku 1Department of Biochemistry and Molecular Medicine, George Washington University School of Medicine and Health Sciences, Washington, D.C. Department of Epidemiology and Biostatistics, School of Public Health, Tianjin Medical University, Tianjin, China; Tianjin Center for International Collaborative Research on Environment, Nutrition and Public Health, Tianjin, China; Tianjin Key Laboratory of Environment, Nutrition and Public Health, Tianjin, China College of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, Hubei, China; Key Laboratory of Environment Correlative Dietology (Huazhong Agricultural University), Ministry of Education, Wuhan, China Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China Key Laboratory of Behavioral Science, Institute of Psychology Chinese Academy of Sciences Beijing China; Graduate School Chinese Academy of Sciences Beijing China Department of PhysiologyUniversity of Texas Health Science Center at San AntonioSan AntonioTX78229USA 10Department of Chemistry, Case Western Reserve University, Cleveland, Ohio. Department of Oncology, The First Affiliated Hospital, Shihezi University School of Medicine, Shihezi City State Key Laboratory of Fundamental Science on Synthetic Vision, College of Computer Science, Sichuan University, Chengdu, Sichuan 610064, China Kunming Police Dog Base of the Ministry of Public Security Kunming Yunnan China Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, China The Comparative Health Outcomes, Policy, and Economics (CHOICE) Institute, Department of Pharmacy, University of Washington, Seattle, Washington Institut für Organische Chemie, RWTH Aachen University, Landoltweg 1, Aachen 52074, Germany Key Laboratory of Functional Inorganic Material Chemistry, Ministry of Education, Heilongjiang University, 74 Xuefu Road, Harbin 150080, P.R. China Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA 15260, 2Department of Electrical Engineering and Computer Science, Case Western Reserve University, Cleveland, OH 44106, 3Department of Biological Sciences and 4Department of Mathematics, University of North Texas, Denton, TX 76203, USA Key Laboratory of Eco-Textiles of Ministry of Education; College of Textiles and Clothing; Jiangnan University; Wuxi 214122; China Key Laboratory of Optoelectronic Technology and System of Ministry of Education, College of Optoelectronic Engineering, Chongqing University, Chongqing 400044, People’s Republic of China Department of Nephrology, PUMC Hospital, CAMS and PUMC, Beijing 100730, China. Key Laboratory of Cancer Prevention and Therapy, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, China College of Medicine and Forensics Xi'an Jiaotong University Health Science Center Xi'an China Jiangsu Key Laboratory of Druggability of Biopharmaceuticals, China Pharmaceutical University, Nanjing 210009, P. R. China Key Laboratory of Resource Biology and Biotechnology in Western China, Northwest University, Ministry of Education, School of Life Sciences, Northwest University, Shaanxi, 710069, China Shanghai Key Laboratory of Advanced Polymeric Materials, School of Materials Science and Engineering, East China University of Science and Technology; Shanghai 200237; China The First Affiliated Hospital of Lanzhou University, Lanzhou, China. Beijing Institute of Fashion Technology, Beijing 100029, China; School of Environment, Tsinghua University, Beijing 100084, China Department of Medicine, Rush University Medical Center, Chicago, IL 60612, USA. School of Pharmacy, Xinxiang Medical University, Xinxiang, Henan 453003, People's Republic of China Department of Pediatrics, Steele Children's Research Center, University of Arizona College of Medicine, Tucson, Arizona; Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, College of Life Sciences, Northwest University, Xi’an, Shaanxi, China State Key Laboratory of Urban and Regional Ecology, Research Centre for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China Faculty of State Key Laboratory of Crop Stress Biology for Arid Areas, College of Agronomy, Northwest A&F University, Yangling 712100, China Department of Interventional Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China; Interventional Institute of Zhengzhou University, Zhengzhou, Henan 450052, China; Interventional Treatment and Clinical Research Center of Henan Province, Zhengzhou, Henan 450052, China Department of Computer and Data Sciences, Case Western Reserve University , Cleveland, Ohio , USA Center for Applied Chemical Research; Frontier Institute of Science and Technology; and State Key Laboratory for Mechanical Behavior of Materials; Xi'an Jiaotong University; Xi'an 710049, China State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, China 1GMU-GIBH Joint School of Life Sciences, Guangzhou Medical University, Guangzhou, China. School of Medicine University of Leeds Leeds LS2 9JT UK State Key Laboratory of Food Science and Technology, Institute for Advanced Study Nanchang University Nanchang Jiangxi 330047 China Tianjin Eye Hospital, Tianjin Key Lab of Ophthalmology and Visual Science, Tianjin Eye Institute, Clinical College of Ophthalmology Tianjin Medical University, Tianjin, China Department of Otorhinolaryngology,the Affiliated Jiangning Hospital of Nanjing Medical University,Nanjing,211100,China. Microbial Genome Research Center, CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, P. R. China; Graduate University of Chinese Academy of Sciences, CAS, Beijing 100049, P. R. China; China General Microbiological Culture Collection Center, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, P. R. China; and Beijing Genomics Institute, Shenzhen 518000, P. R. China Department of Obstetrics, People’s Hospital of Guangxi Zhuang Autonomous Region, Nanning, P.R. China Key Laboratory of Bio-Resources and Eco-Environment (Ministry of Education), College of Life Sciences, Sichuan University, Chengdu, China. University of California San Francisco Guangzhou Institutes of Biomedicine and Health; Chinese Academy of Sciences; Guangzhou 510530; China Key Laboratory for Molecular Genetic Mechanisms and Intervention Research on High Altitude Disease of Tibet Autonomous Region, Xizang Minzu University, Xianyang 712082, Shaanxi, China; Key Laboratory of High Altitude Environment and Gene Related to Disease of Tibet Ministry of Education, School of Medicine, Xizang Minzu University, Xianyang 712082, Shaanxi, China 1Karmanos Cancer Institute, Detroit, Michigan.; 2Department of Oncology, Wayne State University School of Medicine, Detroit, Michigan. Liver Cirrhosis Study Group, Department of Gastroenterology, General Hospital of Shenyang Military Area, Shenyang, Liaoning, China (mainland) Liver Cirrhosis Study Group, Department of Gastroenterology, General Hospital of Shenyang Military Area, 83 Wenhua Road, Shenyang 110840, China College of Chemistry; Chemical Engineering and Environmental Engineering; Liaoning Shihua University; Fushun 113001; P. R. China State Key Laboratory of Electroanalytical Chemistry; Changchun Institute of Applied Chemistry; Changchun; P. R. China; Chinese Academy of Sciences National Engineering Research Center for Biomaterials; College of Biomedical Engineering; Sichuan University; Chengdu 610064; China College of Pharmacy and Research Institute of Pharmaceutical Sciences Seoul National University Seoul 151‐742 Republic of Korea Department of Physiology, Xinjiang Medical University, Urumqi, Xinjiang 830011, P.R. China Department of Chemistry, Rutgers University, Camden, New Jersey 08102, Department of Chemistry, Rutgers University, Piscataway, New Jersey 08855, and Dipartimento di Chimica Strutturale e Stereochimica Inorganica, Università di Milano, 20133 Milano, Italy Department of Biochemistry and Molecular Biology, Harbin Medical University, Harbin, China; Key Laboratory of Cardiovascular Medicine Research (Harbin Medical University), Ministry of Education, Harbin, China; State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Harbin, China State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210093, China; Key Laboratory of Advanced Display Materials and Devices, Ministry of Industry and Information Technology, Institute of Optoelectronics & Nanomaterials, College of Materials Science and Engineering, Nanjing University of Science and Technology, Nanjing 210094, China Central Laboratory, Southern Medical University, Guangzhou, China. Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, 5 Yushan Road, Qingdao, Shandong 266003, People’s Republic of China Microbial Genome Research Center; CAS Key Laboratory of Pathogenic Microbiology and Immunology; Institute of Microbiology; Chinese Academy of Sciences; Beijing; China Shanghai Municipal Center for Disease Control and Prevention, Shanghai 200336, China. State Key Laboratory of Silicon Materials School of Materials Science and Engineering Zhejiang University Hangzhou 310027 China Institute of Plant Protection Jiangsu Academy of Agricultural Sciences Jiangsu Key Laboratory for Food and Safety‐State Key Laboratory Cultivation Base of Ministry of Science and Technology Nanjing 210014 China State Key Laboratory of Transient Optics and Photonics; Xi'an Institute of Optics and Precision Mechanics of CAS; Xi'an 710119; China; School of Future Technology Department of Pathology, Central Hospital of Zibo, Zibo, China Photoelectric Lab, Department of Precision Machinery and Precision Instrument, University of Science and Technology of China, Hefei 230027, China. Department of Respiratory Medicine, Guangdong General Hospital, Guangdong Academy of Medical Science, Guangzhou 510080, China. College of Food Science and Engineering, Ocean University of China, No. 5 Yushan Road, Qingdao, People’s Republic of China Beijing Neurosurgical Institute, Capital Medical University, Beijing, China; State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao Special Administrative Region, China State Key Laboratory of Electroanalytical Chemistry Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun Jilin 130022 China; University of Chinese Academy of Sciences Beijing 100049 China The School of Public Health, Xuzhou Medical College 84 West Huai‐hai Road Xuzhou Jiangsu 221002 China Sichuan Provincial Education Department Key Laboratory of Medicinal and Edible Plant Resources Development, College of Pharmacy, Chengdu University, Chengdu, China Department of Chemistry National University of Singapore 3 Science Drive 3 Singapore 117543 Singapore; Centre for Advanced 2D Materials and Graphene Research Centre National University of Singapore Singapore 117546 Singapore School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang 212013, Peoples Republic of China Department of Infectious Diseases, Research Laboratory of Clinical Virology, National Research Center for Translational Medicine (Shanghai), Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China Jiangsu Key Laboratory of Marine Biological Resources and Environment, Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, School of Pharmacy, Jiangsu Ocean University, Lianyungang 222005, China; Co-Innovation Center of Jiangsu Marine Bio-Industry Technology, Jiangsu Ocean University, Lianyungang 222005, China Department of Cardiology, The General Hospital of Western Theater Command, Chengdu, China State Key Laboratory of Remote Sensing Science, Aerospace Information Research Institute, Chinese Academy of Sciences, Beijing 100101, China; College of Resources and Environment, University of Chinese Academy of Sciences, Beijing 100049, China Key Laboratory of Synthetic and Self-Assembly Chemistry for Organic Functional Molecules, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China School of Materials and Chemical Engineering Xuzhou University of Technology Xuzhou 221018 P.R. China School of Public Health, Xuzhou Medical University, Xuzhou 221004, China; Key Laboratory of Human Genetics and Environmental Medicine, Xuzhou Medical University, Xuzhou 221004, China; Key Lab of Environment and Health, Xuzhou Medical University, Xuzhou 221004, China Division of Cardiovascular Diseases, Mayo Clinic, Rochester, USA. Department of Critical Care Medicine The Third Affiliated Hospital of Guangzhou Medical University Guangzhou Guangdong China; Guangdong Provincial Key Laboratory of Major Obstetric Diseases Guangzhou China; Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology Guangzhou China Henan Institute of Medical and Pharmaceutical Sciences, Academy of Medical Sciences, Zhengzhou University, Zhengzhou, China; BGI College, Zhengzhou University, Zhengzhou, China; Henan Key Medical Laboratory of Tumor Molecular Biomarkers, Zhengzhou University, Zhengzhou, China Department of Biochemical and Cellular Pharmacology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA. State Key Laboratory of Organ Failure Research, Guangdong Key Laboratory of Viral Hepatitis Research, Department of Infectious Diseases and Hepatology Unit Institutes of Liver Diseases Research of Guangdong Province, Nanfang Hospital, Southern Medical University Guangzhou China Department of Molecular and Cellular Pharmacology; School of Pharmaceutical Science and Technology; Tianjin University; Tianjin; China Food Crops Research Institute, Yunnan Academy of Agricultural Sciences, Kunming 650200, China. Department of Medicine, Respiratory, Emergency and Intensive Care Medicine The Affiliated Dushu Lake Hospital of Soochow University Suzhou China Atherosclerosis (J.L.), Merck Research Laboratories, Rahway, New Jersey 07065 School of Life Sciences University of Science and Technology of China Hefei China; State Key Laboratory of Stem Cell and Reproductive Biology Institute of Zoology Chinese Academy of Sciences Beijing China; Institute for Stem Cell and Regeneration Chinese Academy of Sciences Beijing China Department of Physiology and Cardiovascular Research Center, Temple University Medical Center, Philadelphia, PA Department of Ophthalmology, First Hospital of Lanzhou University, Lanzhou 730000, China. Department of Neurosurgery, Huai’an Second People’s Hospital, the Affiliated Huai’an Hospital of Xuzhou Medical University, Huai’an, China; The authors contributed equally to this paper. College of Animal Science and Technology, Shandong Agricultural University, 61 Daizong Street, Taian 271000, China; Shandong Provincial Key Laboratory of Animal Biotechnology and Disease Control and Prevention, 61 Daizong Street, Taian 271000, China; Shandong Provincial Engineering Technology Research Center of Animal Disease Control and Prevention, 61 Daizong Road, Taian 271000, China; Sino-German Cooperative Research Centre for Zoonosis of Animal Origin Shandong Province, 61 Daizong Street, Taian 271000, China School of Marine Sciences Sun Yat-sen University Guangdong Provincial Key Laboratory of Marine Resources and Coastal Engineering Pearl River Estuary Marine Ecosystem Research Station Ministry of Education Southern Laboratory of Ocean Science and Engineering (Guangdong, Zhuhai) Zhuhai 519000 China Department of Oncology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China Department of Pharmacy, Clinical Medical College and The First Affiliated Hospital of Chengdu Medical College, Chengdu, SiChuan, China State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, P. R. China Huaxi MR Research Center (HMRRC), Department of Radiology West China Hospital of Sichuan University Chengdu China Department of Chemical and Petroleum Engineering University of Calgary Alberta T2N 1N4 Canada Changchun Institute of Applied Chemistry Chinese Academy of Sciences Lab Rare Earth Chem Phys CHINA Natural Products LINCHPIN Laboratory and Department of Chemistry, Texas A&M University, P.O. Box 30012, College Station, TX 77843, USA. Institute of Crop Sciences, Chinese Academy of Agricultural Sciences , Beijing 100081 , China School of Acupuncture Moxibustion and Tuina, Beijing University of Chinese Medicine, Beijing 100029, China School of Chemistry and Chemical Engineering, Yancheng Institute of Technology, Yancheng 224051, PR China Department of Oncology, Shanghai University Affiliated Mengchao Cancer Hospital, Shanghai, China State Key Laboratory of Advanced Technology for Materials Synthesis and Processing; Wuhan University of Technology; Wuhan 430070; PR China Laboratory of Photochemistry, Center for Molecular Sciences, Institute of Chemistry, The Chinese Academy of Sciences, Beijing 100080, China Key Laboratory of Drug Quality Control and Pharmacovigilance, China Pharmaceutical University; Center for Instrumental Analysis, China Pharmaceutical University School of Chemistry & Materials Science; Jiangsu Normal University; Xuzhou; P. R. China College of Pharmaceutical Sciences, Zhejiang University, 866 Yu Hang Tang Road, Hangzhou, China Department of Cancer Biology, Prostate Cancer Discovery and Development Program, University of Massachusetts Medical School, Worcester, Massachusetts School of Pharmacy, Xinxiang Medical University, Xinxiang city, Henan Province 453003, People's Republic of China Department of Gynecology and Obstetrics, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. Department of Gastroenterology, Clinical College of Air Force General Hospital, Anhui Medical University, Beijing, China Beijing Key Laboratory of DNA Damage Response and College of Life Sciences, Capital Normal University, 105 Xisanhuan North Road, Beijing, 100048, China Department of Neurosurgery The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology Luoyang China 471003 Department of Gastroenterology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, P.R. China Department of Chemistry Zhejiang University Hangzhou 310027 China; Institute of Biological Engineering Department of Chemical and Biological Engineering, Zhejiang University Hangzhou 310027 Zhejiang China Department of Dermatology Henan Province Hospital of Traditional Chinese Medicine The Second Affiliated Hospital of Henan University of Chinese Medicine Zhengzhou China Department of Anesthesiology, Red Cross Hospital Affiliated to Medical College of Xi'an Jiaotong University, Xi'an 710054, China. Department of Pharmaceutical Chemistry, Xiangya School of Pharmaceutical Sciences, Central South University , Changsha, PR China Department of Burns and Plastic Surgery Second Affiliated Hospital of Air Force Military Medical University Xi'an China Department of Health Statistics, School of Public Health Shanxi Medical University Taiyuan China T.C. Jenkins Department of Biophysics, Johns Hopkins University, Baltimore, MD, United States. Division of Health Policy and Economics, Department of Population Health Sciences, Weill Cornell Medical College, New York, USA Department of Dermatology, Chongqing Traditional Chinese Medicine Hospital Chongqing 400011, P. R. China. Department of Plastic Surgery, Union Hospital, Tongli Medical College of Huazhong University of Science and Technology, Wuhan 430022, China. Department of Respiratory Medicine, Peking University People's Hospital, Beijing, China Department of Chemistry and Chemical Biology, Rutgers University, 610 Taylor Road, Piscataway, New Jersey 08854 a The Chinese University of Hong Kong; b The Chinese University of Hong Kong; c The Chinese University of Hong Kong Department of Obstetrics and Gynecology Nanfang Hospital Southern Medical University Guangzhou Guangdong PR China Department of Neonatology, Children's Hospital Affiliated to Zhengzhou University, Henan Children's Hospital, Zhengzhou Children's Hospital, Zhengzhou, Henan, China. Shanghai Jiao Tong University Affiliated Sixth People's Hospital South Campus Shanghai University of Medicine & Health Sciences Affiliated Sixth People's Hospital South Campus Southern Medical University Affiliated Fengxian Hospital 6600th Nanfeng Road, Fengxian District Shanghai 201 499 China National Clinical Research Center of Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China Beijing Anzhen Hospital of Capital University of Medical Sciences, Beijing 100029, China. Department of Cellular and Molecular Physiology, Yale University, New Haven, Connecticut School of Environmental Studies China University of Geosciences Wuhan 430074 China; Hubei Key Laboratory of Wetland Evolution & Ecological Restoration China University of Geosciences Wuhan 430074 China; Laboratory of Basin Hydrology and Wetland Eco‐restoration China University of Geosciences Wuhan 430074 China Department of Gastroenterology, Peking University First Hospital, Beijing, China Department of Thoracic Surgery Ningxia Medical University General Hospital Yinchuan Ningxia China; Cancer Research Program, JLC‐BBRI North Carolina Central University Durham North Carolina Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, China School of Materials Science and Engineering, Jiangsu Collaborative Innovation Center of Photovolatic Science and Engineering, Changzhou University, Changzhou, Jiangsu 213164, China College of Chemistry, Beijing Normal University, Beijing 100875, China Department of Pulmonary Medicine Zhongshan Hospital Fudan University, Shanghai Respiratory Research Institute Shanghai China BGI Education Center, University of Chinese Academy of Sciences, Shenzhen, China.; BGI-Shenzhen, Shenzhen, China. Department of Pharmacy, Affiliated Hospital of Qingdao University, Shandong, 266000, Qingdao, China School of Chemistry, Xi’an Jiaotong University, Xi’an, Shaan’xi 710049, China 1Department of Oncology, Wayne State University School of Medicine and Barbara Ann Karmanos Cancer Institute, Detroit, Michigan. Department of Hematology, Mongolian Medical Hospital, Fuxin Mongolian Autonomous County 123199, P.R. China The Brain Cognition and Brain Disease Institute, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions, Shenzhen, Guangdong, China Department of Endocrinology and metabolism, Affiliated Hospital of Zunyi Medical University, Zunyi, China Department of Digestive Diseases, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. Lijing1801@126.com School of Integrated Circuits, Dalian University of Technology, No. 321 Tuqiang Road, Dalian 116620, China; Key Laboratory of Materials Modification by Laser, Ion, and Electron Beams (Ministry of Education), School of Physics, Dalian University of Technology, No.2 Linggong Road, Dalian 116024, China Departamento de Química, Universidade de Coimbra, 3004-535 Coimbra, Portugal Single Cell Center Chinese Academy of Sciences Key Laboratory of Biofuels and Shandong Key Laboratory of Energy Genetics Qingdao Institute of BioEnergy and Bioprocess Technology Chinese Academy of Sciences Qingdao Shandong 266101 China School of Chemistry and Chemical Engineering Nanchang University No 999, Xuefu Road Nanchang Jiangxi 330031 China; Institute of Rare Earths Nanchang University No 999, Xuefu Road Nanchang Jiangxi 330031 China Department of Laboratory Medicine & Central Laboratory; Southern Medical University Affiliated Fengxian Hospital; Shanghai; China; Joint Research Center for Precision Medicine MOE Key Laboratory of Low-grade Energy Utilization Technologies and Systems, CQU-NUS Renewable Energy Materials & Devices Joint Laboratory, School of Energy & Power Engineering, Chongqing University, Chongqing 400044, China Department of Entomology and Key Laboratory of Pest Monitoring and Green Management, MOA, College of Plant Protection China Agricultural University Beijing China Institute of Acu-Moxibustion and Meridian, College of Acupuncture and Massage, Anhui University of Chinese Medicine, Hefei, China State Key Laboratory of Pathogens and Bio-security, Academy of Military Medical Sciences, Beijing, China Department of Hepatology, The Affiliated Hospital of Northwest University for Nationalities, The Second People’s Hospital of Gansu Province, China Division of Cardiology, Labatt Family Heart Center, Hospital for Sick Children, Toronto, Ontario, Canada M5G1X8 Department of Rheumatology and Clinical Immunology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, National Clinical Research Center for Dermatologic and Immunologic Diseases, Ministry of Science and Technology, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education , Beijing, China Arizona State University, School of Computing, Informatics and Decision Systems Engineering, Tempe, AZ, USA College of Food Science and Engineering; Ocean University of China; Nucleic Acids Chemistry and Biotechnology Laboratory; Qingdao 266003; China School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China Institute of Cancer Genetics, College of Physicians and Surgeons, Columbia University, New York, New York 10032 West China Hospital of Sichuan University Sichuan Sheng China Xiangya Hospital of Central South University, Central South University, Changsha, Hunan 410008, People's Republic of China School of Pharmacy, Xinxiang Medical University Department of Oncology The First Affiliated Hospital of Zhengzhou University Zhengzhou China College of Pharmacy, Shaanxi University of Chinese Medicine , Xianyang 712046 , China Department of Rheumatology, Affiliated Hospital of Jiangsu University, Jiangsu, China State Key Laboratory of Chemo/Biosensing and Chemometrics Key Laboratory for Bio-Nanotechnology and Molecular Engineering of Hunan Province College of Chemistry and Chemical Engineering College of Biology Hunan University Changsha 410082 China Chief Physician, Department of Stomatology, Nanjing Children's Hospital, Affiliated with Nanjing Medical University, Nanjing, China Department of Rheumatology Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong University Nantong China Temasek Lifesciences Laboratory, 1 Research Link, National University of Singapore, 117604 Singapore; Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, 117543 Singapore State Key Laboratory of Advanced Welding and Joining School of Materials Science and Engineering Harbin Institute of Technology (Shenzhen) Shenzhen 518055 P. R. China; Key Laboratory for Liquid‐Solid Structural Evolution and Processing of Materials (Ministry of Education) Research Center for Carbon Nanomaterials School of Materials Science and Engineering Shandong University Jinan 250061 P. R. China College of Pharmacy; Lanzhou University; Lanzhou 730000, P. R. China From the Department of Surgery, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania Jiangsu Diabetes Center, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, 22 Hankou Road, Nanjing 210093, China Department of Pharmacy, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China Department of Chemistry, CB#3290, University of North Carolina, Chapel Hill, North Carolina 27599,and Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, New Jersey 08854 The 306th Hospital of People's Liberation Army, Beijing, China. Key Laboratory of Hormones and Development (Ministry of Health), Metabolic Disease Hospital & Tianjin Institute of Endocrinology, Tianjin Medical University Department of Medical Oncology, State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Guangzhou, 510060, PR China Heart Center & Beijing Key Laboratory of Hypertension, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China Department of Electrical Engineering and Computer Science, Case Western Reserve University, Cleveland, OH, 44106, USA Shenyang National Laboratory for Materials Science, Institute of Metal Research, Chinese Academy of Sciences, No. 72 Wenhua Road, Shenyang 110016, China Department of Pathology Fan Yu District Central Hospital Guangzhou Guangdong Province China Department of Rheumatology and Immunology, Peking Union Medical College Hospital (PUMCH), Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Beijing, China; Ministry of Education, Key Laboratory of Rheumatology and Clinical Immunology, Beijing, China Chongqing Academy of Animal Science, Rongchang District, Chongqing 402460, China; Chongqing Engineering Research Center of Goose Genetic Improvement, Rongchang District, Chongqing 402460, China State Key Laboratory of Urban and Regional Ecology Research Centre for Eco‐Environmental Sciences, Chinese Academy of Sciences Beijing 100085 China State Key Laboratory of Advanced Welding and Joining School of Materials Science and Engineering Harbin Institute of Technology (Shenzhen) Shenzhen 518055 China; Key Laboratory for Liquid‐Solid Structural Evolution & Processing of Materials (Ministry of Education) School of Materials Science and Engineering Shandong University Jinan 250061 China Shandong Agricultural University/State Key Laboratory of Crop Biology College of Horticulture Science and Engineering, , Tai’an, Shandong 271018, China; Ministry of Agriculture and Rural Affairs Key Laboratory of Biology and Genetic Improvement of Horticultural Crops (Huanghuai Region), , Tai’an, Shandong 271018, China; Shandong Agricultural University Shandong Collaborative Innovation Center for Fruit and Vegetable Production with High Quality and Efficiency, , Tai’an, Shandong 271018, China School of Chemistry and Chemical Engineering Chongqing University Shapingba 174 Chongqing 400044 China Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China. zzhlq3@hotmail.com. Laboratory of Stem Cell and Tissue Engineering, Chongqing Medical University, Chongqing 400016, P.R. China State Key Laboratory of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, P. R. China; Frontiers Science Center for New Organic Matter, College of Chemistry, Nankai University, Tianjin 300071, P. R. China Safety, Environment and Technology Supervision Research Institute, PetroChina Southwest Oil and Gas Field Company, Chengdu, People’s Republic of China; Sichuan Key Laboratory of Evaluation and Exploitation of Shale Gas, Chengdu, People’s Republic of China State Key Laboratory of Natural Medicines Department of Pharmaceutics China Pharmaceutical University Nanjing 210009 P. R. China Department of Urinary Surgery, First People’s Hospital of Jinan, Jinan, Shandong, China Department of Hematology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, People’s Republic of China Yunnan Provincial Key Lab of Soil Carbon Sequestration and Pollution Control, Faculty of Environmental Science & Engineering, Kunming University of Science & Technology, Kunming, Yunnan, People’s Republic of China Key Laboratory of Acupuncture of Tianjin, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China Beijing Advanced Innovation Center for Soft Matter Science and Engineering, and State Key Laboratory of Organic−Inorganic Composites, Beijing University of Chemical Technology, Beijing 100029, P. R. China Department of Biomedical Engineering; School of Materials Science and Engineering; South China University of Technology; Guangzhou 510641; China Laboratory of Molecular Biology of Tomato, Bioengineering College, Chongqing University, Chongqing, People’s Republic of China Department of Forensic Science, School of Basic Medical Sciences, Central South University, Changsha, Hunan 410013, China. Department of Infectious Diseases, Huashan Hospital, Fudan University, Shanghai 200032, P.R. China Shenyang National Laboratory for Materials Science (SYNL), Institute of Metal Research (IMR), Chinese Academy of Sciences (CAS), No. 72 Wenhua Road, Shenyang 110016 China School of Renewable Energy, North China Electric Power University, Beijing, China Department of Neurology Weihai Municipal Hospital, Cheeloo College of Medicine, Shandong University Weihai China; Department of Neurology Weifang Medical University Weifang China Department of Obstetrics, Affiliated Hospital of Qingdao University, Qingdao, China Hebei Mental Health Center, Hebei, China Department of Epidemiology and Biostatistics, School of Public Health Tianjin Medical University Tianjin China; Tianjin Key Laboratory of Environment Nutrition and Public Health Tianjin China; Tianjin Center for International Collaborative Research on Environment Nutrition and Public Health Tianjin China Key Lab of Molecular Biophysics of Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, 1037 Luoyu Road, Wuhan 430074, China School of Marine Sciences, Sun Yat-Sen University, Guangzhou 510006, China Program in Cellular and Molecular Medicine, Boston Children’s Hospital, Boston, MA 02115;; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115 Department of Chemistry, University of Shanghai for Science and Technology, Shanghai 200093, P. R. China Department of Healthcare Policy & Research, Weill Cornell Medical College, New York, NY 10065, USA Department of Epidemiology and Health Statistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu 610041, China. Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Peking Union Medical College Hospital, Beijing Key Laboratory of New Drug Development and Clinical Trial of Stem Cell Therapy, Beijing, 100005, China College of Life Sciences, Shanghai Normal University, Shanghai 220234, PR China; Division of Glycoscience, Department of Chemistry, School of Engineering Sciences in Chemistry, Biotechnology and Health, Royal Institute of Technology (KTH), AlbaNova University Center, Stockholm SE10691, Sweden; School of Pharmacy, College of Pharmacy, Taipei Medical University, 250 Wuxing Street, Taipei 110, Taiwan Department of Gastroenterology and Hepatology Tongji Hospital School of Medicine Tongji University Shanghai China College of Animal Science and Technology, Northwest A&F University, Yangling 712100, China Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Haihe Education Park, 38 Tongyan Road, Tianjin 300353, People’s Republic of China; Department of Chemistry and Center of Diagnostics & Therapeutics, Georgia State University, 50 Decatur St SE, Atlanta, Georgia 30303, United States Department of Respiratory Medicine, Zhongshan Hospital, Fudan University, Shanghai, China;; Shanghai Respiratory Research Institute, Shanghai, China; and The State Key Laboratory of Natural and Biomimetic and Drugs and Department of Pharmaceutical Analysis School of Pharmaceutical Sciences and Peking University Beijing 100191 People's Republic of China Department of Nutrition and Food Hygiene, School of Public Health, Qingdao University, 308 Ningxia Road, Qingdao 266071, China State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, Guangdong Laboratory for Lingnan Modern Agriculture, College of Life Sciences, South China Agricultural University , Guangzhou 510642, China Methadone Maintenance Treatment Clinic, Compulsory Isolation Drug Rehabilitation Center, Taiyuan, Shanxi, China College of Marine Life Sciences, Ocean University of China, Qingdao 266003, People’s Republic of China Department of Epidemiology and Biostatistics School of Public Health, Research Center of Basic Medical Sciences, Tianjin Medical University Tianjin China Research Center of Bioenergy and Bioremediation, College of Resource and Environment, Southwest University, Chongqing 400715, China College of Pharmacy; Jinan University; Guangzhou 510632; China; Research Center for Marine Drugs State Key Laboratory of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, China, Department of Materials Science and Engineering; Southern University of Science and Technology; Shenzhen; P. R. China Department of Biochemistry, Beckman Institute for Advanced Science and Technology, and Center for Biophysics and Computational Biology, University of Illinois at Urbana-Champaign, 405 North Mathews Avenue, Urbana, Illinois 61801, United States The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, PR China. lijing1982wh@163.com. Department of Endocrinology and Metabolism, Institute of Endocrinology, The First Affiliated Hospital, China Medical University, Liaoning Provincial Key Laboratory of Endocrine Diseases, Shenyang, P. R. China Department of Radiology, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou 450000, China Department of Ultrasound the First Affiliated Hospital of Wannan Medical College Wuhu Anhui China Department of Information Management, School of Economics and Management, Beijing Jiaotong University, Beijing 100044, China (Li J, Li M, Zhao XK); Department of Emergency, Chinese PLA General Hospital, Beijing 100853, China (Zhao YZ, Li TS). Corresponding author: Li Tanshi, Email: lts301@163.com. Nursing Department The Second Hospital of Hebei Medical University Shijiazhuang China Department of Medical Research Shanghai MajorMed Diagnostics Company Shanghai China State Key Laboratory of Bioelectronics, Jiangsu Key Laboratory for Biomaterials and Devices, School of Biological Sciences and Medical Engineering, Southeast University, Nanjing 210096, China State Key Laboratory of Food Nutrition and Safety (Tianjin University of Science and Technology); Tianjin 300457; China Functional Nanomaterials Laboratory, Center for Micro/Nanomaterials and Technology and Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Zhongguancundonglu 29, Haidianqu, Beijing 100190, China Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun 130021, China School of Environment and Energy, Guangdong Provincial Key Laboratory of Solid Wastes Pollution Control and Recycling, South China University of Technology, Guangzhou, Guangdong 510006, P. R. China; The Key Laboratory of Pollution Control and Ecosystem Restoration in Industry Clusters (Ministry of Education), Guangzhou, Guangdong 510006, P. R. China Center for Metabolic Biology, Iowa State University, Ames, IA 50014, USA; Department of Genetics Development and Cell Biology, Iowa State University, Ames, IA 50014, USA University of Arizona Health Science Center, Tucson, Arizona Department of Radiology Changhai Hospital of Shanghai, Second Military Medical University Shanghai China Department of Burn and Plastic Surgery, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China Department of Gastroenterology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, P. R. China College of Applied Sciences, Beijing University of Technology, Beijing 100124, China Collaborative Innovation Center for Optoelectronic Semiconductors and Efficient Devices, Department of Physics/Pen-Tung Sah Institute of Micro-Nano Science and Technology, Xiamen University, Xiamen, Fujian, 361005 China; State Key Laboratory for Manufacturing Systems Engineering Xi’an Jiaotong University, Xi’an, Shaanxi, 710049 P.R. China; Department of Mechanical Engineering, University of California, Berkeley, California 94720, United States Max Planck Institute for Polymer Research, Ackermannweg 10, 55128 Mainz, Germany Genentech, South San Francisco, CA; Key Laboratory of Functional Inorganic Material Chemistry Ministry of Education & School of Chemistry and Material Science Heilongjiang University 74 Xuefu Road Harbin 150080 PR China Institute of Biomechanics and Medical Engineering; AML; Department of Engineering Mechanics; Tsinghua University; Beijing 100084, P. R. China College of Animal Science and Technology Northwest A&F University Xianyang Shaanxi China Department of Chemical and Pharmaceutical Engineering, College of Chemical Engineering, Huaqiao University, Xiamen, Fujian 361021, China Sichuan Key Laboratory of Conservation Biology on Endangered Wildlife College of Life Sciences Sichuan University Chengdu 610064 China College of Food Science and Nutritional Engineering, China Agricultural University Beijing China; National Engineering Research Center for Fruit & Vegetable Processing Beijing China; Key Laboratory of Fruit & Vegetable Processing Ministry of Agriculture and Rural Affairs Beijing China; Beijing Key Laboratory for Food Non‐thermal Processing Beijing China Provincial Key Laboratory of Pharmaceutics in Guizhou Province, School of Pharmacy Guiyang Medical University 9 Beijing Road Guiyang Guizhou 550004 PR China Institute of Cardiology, Tongji Medicd College, Huazhong Science and Technology University, Human Genome Research Center of Wuhan Union Hospital, Wuhan, Hubei, 430022, PR China. MIIT Key Laboratory of Advanced Display Materials and Devices, School of Materials Science and Engineering, Nanjing University of Science and Technology, Nanjing210094, China Faculty of Pharmacy, Bengbu Medical College, Bengbu 233030, China. E-mail: lijing2828@126.com. Hypertension Center of People’s Hospital of Xinjiang Uygur Autonomous Region, Xinjiang Hypertension Institute, National Health Committee Key Laboratory of Hypertension Clinical Research, Key Laboratory of Xinjiang Uygur Autonomous Region, Hypertension Research Laboratory, Xinjiang Clinical Medical Research Center for Hypertension (Cardio-Cerebrovascular) Diseases, Urumqi, Xinjiang China Tianjin University of Traditional Chinese Medicine, Tianjin 300193, P. R. China Department of Physiology and Functional Genomics (E.M.R., J.L., B.R.S., M.K.R.), University of Florida College of Medicine, Gainesville, Florida. Clinical Metabolomics Center, China Pharmaceutical University, Nanjing (J.L., Y.-Y.C., G.M., B.L., L.-W.Q.) Department of Respiratory and Critical Care Medicine, the Second Xiangya Hospital, Central South University, Changsha, Hunan, China; Research Unit of Respiratory Disease, Central South University, Changsha, Hunan, China; Diagnosis and Treatment Center of Respiratory Disease, Central South University, Changsha, Hunan, China Department of Cancer Epidemiology, Cancer Institute & Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, P.R. China Jilin Technology Innovation Centre for Chinese Medicine Biotechnology College of Biology and Chemistry, Beihua University Jilin Jilin China Spoon‐billed Sandpiper (Shanghai) Environmental Protection Technology Co., Ltd Shanghai China School of Pharmacy, Shenyang Medical College, Shenyang, PR China From the Multidisciplinary Cardiovascular Research Centre (J.N., J.L., C.J.M., F.Z., P.S., B.H., A.S., N.Y., Y.M., D.B., S.J., V.A.L.S., L.M., S.B.W., M.T.K., K.E.P., D.J.B.), Institute of Membrane & Systems Biology (J.N., J.L., C.J.M., F.Z., P.S., B.H., A.S., Y.M., D.B., S.J., V.A.L.S., L.M., B.K., D.J.B.), and Faculties of Biological Sciences (J.N., J.L., C.J.M., F.Z., P.S., B.H., A.S., Y.M., D.B., S.J., V.A.L.S., L.M., B.K., D.J.B.) and Medicine & Health (N.Y., S.B.W., M.T.K., K.E.P.),... Department of Materials and Chemistry Engineering Guilin University of Technology Guilin China a Key Laboratory of Urban Stormwater System and Water Environment, Ministry of Education, Beijing University of Civil Engineering and Architecture, Beijing 100044, China; b National Demonstration Center for Experimental Water Environment Education, Beijing University of Civil Engineering and Architecture, Beijing 100044, China State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Research Unit of Oral Carcinogenesis and Management, Chinese Academy of Medical Sciences, West China Hospital of Stomatology Sichuan University Chengdu China First Ward of Orthopedics Department, The Affiliated Hongqi Hospital of Mudanjiang Medical University, Mudanjiang, 157011, China State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia Medica Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100050 P. R. China Institute of Nuclear Physics and Chemistry, China Academy of Engineering Physics, Mianyang 621900, China Genomics Institute of the Novartis Research Foundation (GNF) 10675 John Jay Hopkins Drive San Diego CA 92121 USA Advanced Materials Institute Qilu University of Technology (Shandong Academy of Sciences) Jinan China; Advanced Materials Institute, Shandong Provincial Key Laboratory of High Strength Lightweight Metallic Materials Qilu University of Technology (Shandong Academy of Sciences) Jinan China Department of Orthopedics; The Second Affiliated Hospital of Xi'an Jiaotong University; Xi'an; China Cottage Health Research Institute, Santa Barbara Cottage Hospital, Santa Barbara, CA, USA Institute of Human Virology University of Maryland School of Medicine 725 West Lombard Street Baltimore MD 21201 USA; Department of Epidemiology and Biostatistics, School of Public Health Peking University Health Science Center Beijing China Department of Radiology Beijing Friendship Hospital Capital Medical University Beijing China Department of Quality Management, Zhejiang Hospital, Hangzhou, Zhejiang, China CAS Key Laboratory of Pathogenic Microbiology and Immunology Institute of Microbiology Chinese Academy of Sciences Beijing China; Savaid Medical School University of Chinese Academy of Sciences Beijing China Department of Plant Pathology, College of Plant Protection, China Agricultural University, Beijing, China CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology; Chinese Academy of Sciences; Beijing China Department of Pharmacy Renmin Hospital of Wuhan University Wuhan, China Photoelectric Lab, Department of Precision Machinery and Precision Instrument, University of Science and Technology of China, Hefei 230027, China. lijing@ustc.edu.cn Department of Otolaryngology, Hangzhou First People's Hospital, Nanjing Medical University, Hangzhou 310006, China. Department of Echocardiography and Vascular Ultrasound Center, The First Affiliated Hospital, Zhejiang University School of Medicine, 79 Qingchun Road, Hangzhou, Zhejiang Province 310003, China Department of Pathology, Central Hospital of Zibo, Zibo, Shandong, China Department of Endocrinology and Metabolism, The Affiliated Hospital of Medical School of Ningbo University, Ningbo, Zhejiang 315020, P.R. China Department of Internal Medicine, Municipal Hospital, Qingdao, Shandong, People’s Republic of China 1The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland; Department of Urology, Xinxiang Central Hospital, Xinxiang, China Key Laboratory of Photochemical Conversion and Optoelectronic Materials; Technical Institute of Physics and Chemistry; Chinese Academy of Sciences; Beijing 100190; China Chinese Academy of Sciences Key Laboratory of Receptor Research, National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, P.R. China Helmholtz-Zentrum Geesthacht, Centre for Materials and Coastal Research, Institute of Coastal Research, Geesthacht, 21502, Germany; University of Hamburg, School of Integrated Climate System Sciences, Hamburg, 20144, Germany a Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Peking Union Medical College Hospital Center of Excellence in Tissue Engineering Chinese Academy of Medical Sciences, Beijing Key Laboratory (No.BZO381), Beijing, People's Republic of China Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Peking Union Medical College Hospital, Center of Excellence in Tissue Engineering, School of Basic Medicine, Peking Union Medical College, Beijing 100005, China Jiangxi College of Applied Technology, Ganzhou 341000, China; Engineering Research Center of Nano-Geo Materials of Ministry of Education, China University of Geosciences, Wuhan 430074, China Beijing Engineering Research Center for Experimental Animal Models of Human Diseases, Institute of Laboratory Animal Science, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China Key Laboratory of Industrial Microbiology, Ministry of Education, College of Biotechnology Tianjin University of Science & Technology Tianjin 300457 China Pen-Tung Sah Institute of Micro-Nano Science and Technology; Xiamen University; Xiamen, China College of Pharmacy Jinan University Guangzhou 510632 P. R. China; Research Center for Marine Drugs State Key Laboratory of Oncogenes and Related Genes Department of Pharmacy Ren Ji Hospital School of Medicine Shanghai Jiao Tong University Shanghai 200127 P. R. China Department of Acupuncture and Moxibustion, Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Nanjing 210000, Jiangsu Province. College of Integrated Chinese and Western Medicine, Hebei Medical University, Shijiazhuang, Hebei, 050017, China State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 China; School of Applied Chemistry and Engineering University of Science and Technology of China Hefei 230026 China Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Dongdan Santiao No. 5, Beijing 100005, China Key Laboratory for Polymeric Composite and Functional Materials of Ministry of Education Key Laboratory of High Performance Polymer‐Based Composites of Guangdong Province School of Chemistry Sun Yat‐Sen University Guangzhou 510275 China Institute of Fundamental and Frontier Sciences, University of Electronic Science and Technology of China, Chengdu 610054, China Department of Chemistry Graduate School of Science Tohoku University Aza Aramaki, Aoba-ku Sendai 980-8578 Japan Key Laboratory of Materials Modification by Laser; Ion; and Electron Beams (Ministry of Education); Dalian University of Technology; Dalian 116024 Department of Surgical Oncology, The First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233000, P.R. China Department of Neurological Surgery, and Department of Nursing, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, China Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, 190 Kaiyuan Avenue, Guangzhou 510530, People’s Republic of China Karmanos Cancer Institute Wayne State University School of Medicine Detroit Michigan USA Cancer Research Center Nantong, Nantong Tumor Hospital and Affiliated Tumor Hospital of Nantong University, Nantong, China Department of Radiology, The First Hospital (Eastern Division) of Jilin University, Changchun, Jilin, China Department of Clinical Laboratory The First Affiliated Hospital of Nanchang University Nanchang China Department of Physiology and Functional Genomics, College of Medicine University of Florida Gainesville Florida USA Nanjing Drum Tower Hospital Center of Molecular Diagnostic and Therapy, Chinese Academy of Medical Sciences Research Unit of Extracellular RNA, State Key Laboratory of Pharmaceutical Biotechnology, Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, NJU Advanced Institute of Life Sciences (NAILS), Institute of Artificial Intelligence Biomedicine, School of Life Sciences, Nanjing University, Jiangsu, China (Z.W., Y.T., J.X., H.W., Y.S., L.C., Jing Li, Y.Z., X.C., D.W., C.-Y.Z.... State Key Laboratory of Respiratory Disease; Guangzhou Institutes of Biomedicine and Health; Chinese Academy of Sciences; Guangzhou 510530; China Department of Intensive Care Unit, The First Hospital of Jilin University, Changchun 130021, China Mental Health Center, West China Hospital of Sichuan University, Chengdu, China; College of Pharmacy, Jiamusi University, Jiamusi 154007, China Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research (Ministry of Education), College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha 410081, P. R. China; Department of Chemical Engineering and Textile, Shaanxi Polytechnic Institute, Xianyang 721000, P. R. China NHC Key Laboratory of Carcinogenesis, Department of Hematology, Xiangya Hospital, Central South University, Changsha, China; Department of Microbiology, School of Basic Medical Sciences, Central South University, Changsha, China; China-Africa Research Center of Infectious Diseases, Central South University, Changsha, China Department of Humanity and Art, School of Public Health and Management, Chongqing Medical University, Chongqing, SC, China National Cancer Center/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, Liaoning, China; Cell Therapy Laboratory, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei 050031, China; Department of Immunology, Basic Medical College, Hebei Medical University, Shijiazhuang, Hebei 050017, China Key Laboratory of Colloid and Interface Chemistry Ministry of Education Shandong University Jinan People's Republic of China School of Economics and Management, Beijing Jiaotong University, Beijing, China Hypertension Center, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; Heart Center & Beijing Key Laboratory of Hypertension, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China Institute of Diagnostic and Interventional Radiology; Shanghai Jiao Tong University Affiliated Sixth People's Hospital; Shanghai; China Department of Burn and Plastic Surgery, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China Department of Mechanical Engineering; Johns Hopkins University; Baltimore; USA; Hopkins Extreme Materials Institute School of Materials and Metallurgy, University of Science and Technology Liaoning, Anshan 114051, China Department of Orthodontics, Shandong Provincial Key Laboratory of Oral Tissue Regeneration, School of Stomatology, Shandong University, Jinan, P. R. China Department of Ultrasound, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100037. Department of Dermatology, Shanghai Eighth People’s Hospital, Shanghai, China Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu, China Clinical School of Acupuncture and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou, China Department of Radiology Changhai Hospital Shanghai China Department of Materials Science and Engineering Southern University of Science and Technology 1088 Xueyuan Blvd. Nanshan District Shenzhen, Guangdong 518055 P.R. China Departamento de Química, Universidade de Coimbra, 3004-535 Coimbra,Portugal Shenzhen Key Laboratory of Interfacial Science and Engineering of Materials, State Environmental Protection Key Laboratory of Integrated Surface Water-Groundwater Pollution Control, Guangdong Provincial Key Laboratory of Soil and Groundwater Pollution Control, School of Environmental Science and Engineering, Southern University of Science and Technology, Shenzhen 518055, China Department of Respiratory and Critical Care, Hebei PetroChina Central Hospital, Langfang, China Key Laboratory of Medical Imaging Research and Application of Hebei Province, Hebei Medical University, Shijiazhuang, Hebei, China Key Laboratory of Education Ministry on Traditional Chinese Medicine Resource and Compound Prescription Hubei University of Chinese Medicine Wuhan 430065 China Division of Abdominal Tumor Multimodality Treatment Cancer Center NHC Key Lab of Transplant Engineering and Immunology Regenerative Medicine Research Center West China Hospital Sichuan University Chengdu 610041 China; Sichuan Provincial Engineering Laboratory of Pathology in Clinical Application West China Hospital Sichuan University Chengdu 610041 China; Institutes for Systems Genetics Frontiers Science Center for Disease‐Related Molecular Network West China Hospital Sichuan University Chengdu 610041 China Department of Clinical Laboratory Capital Institute of Pediatrics Beijing China Department of Pathophysiology, College of Basic Medicine, Chongqing University of Medical Sciences, Chongqing 400016, China. College of Food Science and Engineering Qilu University of Technology Jinan China Key Laboratory of Forest and Flower Genetics and Breeding of Ministry of Education, College of Biological Science and Technology, Beijing Forestry University, Beijing 100083, China College of Life Science, Engineering Research Center of the Chinese Ministry of Education for Bioreactor and Pharmaceutical Development, Jilin Agricultural University, Changchun, PR China for the RICAMIS Investigators Department of Chemistry; State University of New York at Binghamton; Binghamton; USA Hoffmann Institute of Advanced Materials Shenzhen Polytechnic 7098 Liuxian Blvd Nanshan District, Shenzhen 518055 People's Republic of China; Department of Chemistry and Chemical Biology Rutgers University 123 Bevier Road Piscataway NJ 08854 USA Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, 410008 PR China. Department of Bone Surgery, Affiliated Hongqi Hospital, Mudanjiang Medical University, Mudanjiang, Heilongjiang 157011, P.R. China Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of China Chengdu 610054 P. R. China Department of Pediatrics, University of Chicago, Chicago, Illinois School of Pharmaceutical Sciences, South-Central University for Nationalities, 430000 Wuhan, Hubei, China. Department of Cardiothoracic Surgery, People's Hospital of Changshou, Chongqing 401220, P.R. China Institute of Basic Medical Sciences and School of Basic Medicine, Center of Excellence in Tissue Engineering, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China. The Innovative Fine Chemical Co., Ltd. Yixing China Key Laboratory of Plant Germplasm Enhancement and Specialty Agriculture, Wuhan Botanical Garden, Chinese Academy of Sciences, Wuhan 430074, China; Department of Physiology and Aging, University of Florida College of Medicine, Gainesville, FL 32610, USA Institute for Translational Medicine, The Affiliated Hospital of Qingdao University, Medical College, Qingdao University, Qingdao, China State Key Laboratory of Organ Failure Research, National Clinical Research Center of Kidney Diseases, Division of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou, China, Bioland Laboratory (Guangzhou Regenerative Medicine and Health Guangdong Laboratory), Guangzhou, China Beijing Engineering Research Center of Environmental Material for Water Purification, College of Chemical Engineering, Beijing University of Chemical Technology, Beijing 100029, China Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China Department of Orthopaedics, Xijing Hospital Affiliated to the Air Force Medical University, Xi'an Shaanxi, 710032, P.R.China.zyfmmu@fmmu.edu.cn. Department of Physiology and Pathophysiology, Peking University Health Science Center,; Key Laboratory of Cardiovascular Science of the Ministry of Education, State Key Laboratory of Coordination Chemistry Collaborative Innovation Center of Advanced Microstructures School of Chemistry and Chemical Engineering Nanjing University Nanjing 210023 P. R. China Department of Radiology, The Affiliated Hospital of Jining Medical University; Shandong-China. lijingmeical@163.com. Harbin Medical University, Harbin, P. R. China; Wenzhou Medical University, Wenzhou College of Pharmacy, Jinan University, Guangzhou 510632, China. Research Institute of Pomology Chinese Academy of Agricultural Sciences Xingcheng China Department of Pediatrics, University of Arizona Health Sciences Center, Tucson, Arizona; and School of Materials and Chemistry, University of Shanghai for Science and Technology, No. 516 Jungong Road, Shanghai 200093, China Department of Data and Information, The Children’s Hospital Zhejiang University School of Medicine, Hangzhou 310052, China; Sino-Finland Joint AI Laboratory for Child Health of Zhejiang Province, Hangzhou 310052, China; National Clinical Research Center for Child Health, Hangzhou 310052, China State Key Laboratory of Integrated Optoelectronics, Institute of Semiconductors, Chinese Academy of Sciences, No. A35, Qinghua East Road, Haidian District, Beijing 100083, China; Center of Materials Science and Optoelectronic Engineering, University of Chinese Academy of Sciences, No. 19A, Yuquan Road, Shijingshan District, Beijing 100049, China Key Laboratory of Green Prevention and Control of Tropical Plant Diseases and Pests (Hainan University), Ministry of Education, Haikou, Hainan Province, China; College of Plant Protection, Hainan University, Haikou, Hainan Province, China Department of Virology, School of Public Health, Shandong University, Jinan 250012, Shandong, China; The Second Hospital of Shandong University, Jinan 250033, Shandong, China. Department of Radiation Medicine and Protection, Faculty of Preventive Medicine The Fourth Military Medical University Xi'an Shaanxi People's Republic of China State Key Laboratory of Vegetation and Environmental Change Institute of Botany Chinese Academy of Sciences Beijing 100093 China; College of Resources and Environment University of Chinese Academy of Sciences Beijing 100049 China Department of Epidemiology and Biostatistics School of Public Health Tianjin Medical University Tianjin China; Tianjin Key Laboratory of Environment Nutrition and Public Health Tianjin China; Tianjin Center for International Collaborative Research on Environment Nutrition and Public Health Tianjin China Department of Biochemistry, University of Toronto, Toronto, ON, Canada; and Xuan Wu Hospital, Capital Medical University, Beijing, China. From the Department of Pharmacology (E.L.L., A.B.D., J.W., J.L., C.T.S., M.A.C.), New York Medical College, Valhalla, NY; Molecular Genetics (J.R.F.), University of Texas Southwestern Medical Center, Dallas, Tex. Songjiang District Zhongshan Street Community Healthcare Center Shanghai China Institute of Psychology, Chinese Academy of Sciences, Beijing, China Key Laboratory of Cluster Science, Ministry of Education of China, School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing 100081, China BGI‐Shenzhen Shenzhen 518083 PR China; China National GeneBank, BGI‐Shenzhen Shenzhen 518120 China Sustainable Energy Laboratory, Faculty of Materials Science and Chemistry, China University of Geosciences, Wuhan 430074, China Department of Obstetrics and Gynecology, Nanfang Hospital Southern Medical University Guangzhou China Department of Endocrinology and Metabolism , Institute of Endocrine, NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Hospital of China Medical University , Shenyang , P.R. China Department of Infectious Diseases, Tangdu Hospital, Fourth Military Medical University, Xi’an, Shaanxi Province, China The Research Institute for the Development Strategy of the Equine Industry, Chifeng University, Chifeng, China; College of Chemistry and Life Science, Chifeng University, Chifeng, China Department of Neurology, The Affiliated Suzhou Hospital of Nanjing University Medical School, Jiangsu, China Key Laboratory of Environmental Material and Environmental Engineering of Jiangsu Province, College of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225002, China Department of Bioinformatics and Biostatistics, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, People’s Republic of China Department of Pediatric Intensive Care Unit, Critical Care Medicine Center, Women and Children's Hospital, Qingdao University, Qingdao, Shandong 266000, China. lisang1976@aliyun.com. Department of Rheumatology and Immunology, Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis, Peking University People’s Hospital, Beijing, China School of Psychology, Central China Normal University Department of Burns and Plastic Surgery Second Affiliated Hospital of Air Force Military Medical University Xi'an 710038 P. R. China Department of Functional Medicine, School of Basic Medical Sciences Jiamusi University Jiamusi China Department of Intensive Care Medicine The First Affiliated Hospital of Soochow University SuZhou China Department of Life Sciences Bengbu Medical College Bengbu Anhui PR China School of Physics and Physical Engineering, Shandong Provincial Key Laboratory of Laser Polarization and Information Technology, Qufu Normal University, 273165, Qufu, China Target Validation, Merck and Co., Inc., Rahway, NJ 07065, U.S.A. Department of Cardiology, Tianyou Hospital, Affiliated to Wuhan University of Science and Technology, Wuhan, Hubei, China. MD Anderson Cancer Center, Houston, TX College of Pharmacy, Southwest Minzu University, Chengdu, People’s Republic of China Life-Science College, Nankai University, Tianjin. Division of Cardiovascular Diseases Mayo Clinic Rochester Minnesota Anshun University, Guizhou, Anshun 561000, China Department of Operating Room, West China Hospital, Sichuan University/West China School of Nursing, Sichuan University, Chengdu, Si Chuan, PR China School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, China National Clinical Research Center for Cardiovascular Diseases, NHC Key Laboratory of Clinical Research for Cardiovascular Medications, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, National Center for Cardiovascular Diseases, Beijing 100037, China Department of Gastroenterology The First Affiliated Hospital of Xi'an Jiaotong University Xi'an China College of Life Sciences, Wuhan University, Wuhan 430072, China Key Laboratory of Horticultural Plant Biology, Ministry of Education, Huazhong Agricultural University, Wuhan, China Department of Gynecology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China Huadong Research Institute for Medicine and Biotechniques, 210002, #293 Zhongshandonglu, Nanjing, Jiangsu, China College of Environment and Ecology, Chengdu University of Technology the Second Outpatient Department, Sichuan Cancer Hospital, Chengdu 610041, China. Department of Preventive Medicine, School of Public Health, Fujian Medical University, Fuzhou 350122, China National Clinical Research Center for Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China. Evidence-Based Medicine Center, School of Basic Medical Sciences; Lanzhou University; Lanzhou China; Evidence-Based Social Science Research Center, School of Public Health; Lanzhou University; Lanzhou China From the Department of Cardiology, Institute of Cardiovascular Diseases, First Affiliated Hospital of Dalian Medical University, China (J.L., X.-L.Y., Y.-L.Z., Y.-Z.Y., H.-H.L.); Department of Nutrition and Food Hygiene, School of Public Health, Dalian Medical University, China (J.B., H.-H.L.); and Department of Ophthalmology (S.W.) and Department of Radiotherapy Oncology (Y.-L.C.), The Second Affiliated Hospital of Dalian Medical University, China. Key Laboratory for Advanced Materials and Institute of Fine Chemicals, East China University of Science & Technology, Shanghai 200237, P. R. China Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China 2Merck Research Laboratories, North Wales, Pennsylvania. Department of Medicinal and Applied Chemistry; Kaohsiung Medical University; Kaohsiung City 807; Taiwan Department of Neurology, The First Hospital of Jilin University, Changchun, Jilin, China International Flavors & Fragrances Inc, R&D Union Beach NJ USA Department of Orthopaedics The Fourth Medical Center, Chinese PLA General Hospital Beijing China College of Electrical Enginerring, Zhejiang University, Hangzhou 310027, China. ljagu@163.com Department of Pathology, the General Hospital of Beijing Military Command, Beijing 100700, China. State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology Chinese Academy of Sciences Beijing China State Key Laboratory of Robotics and System Harbin Institute of Technology Harbin 150001 China Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology, Qingdao 266003, China Department of Ophthalmology, Shaanxi Provincial People's Hospital, Xi'an, Shaanxi 710068, P.R.�China Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College; National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Ministry of Science & Technology; State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital (PUMCH); Key Laboratory of Rheumatology, and Clinical Immunology, Ministry of Education, Beijing, China State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China. Shandong Provincial Key Laboratory of Chemical Energy Storage and Novel Cell Technology; College of Chemistry and Chemical Engineering; Liaocheng University; Liaocheng; P. R. China Dental Medical Center, China-Japan Friendship Hospital, Beijing 100029, China Department of Otolaryngology, Head and Neck Surgery, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, China Department of Central Laboratory The First Affiliated Hospital of Bengbu Medical College Bengbu China; Department of Clinical Laboratory The First Affiliated Hospital of Bengbu Medical College Bengbu China Department of Nephrology Chengdu First People's Hospital, Chengdu Sichuan China Linde + Robinson Laboratories, California Institute of Technology, Pasadena, California 91125, United States Key Laboratory of Green Chemistry & Technology of Ministry of Education College of Chemistry Sichuan University Chengdu 610064 P. R. China The Department of Cardiology General Hospital of Shenyang Military Region Shenyang China Institute of Plant Protection, Jiangsu Academy of Agricultural Sciences Jiangsu Key Laboratory for Food and Safety‐State Key Laboratory Cultivation Base of Ministry of Science and Technology Nanjing China Department of Gastroenterology, Peking University People's Hospital, Beijing 100044, China Acupuncture and Massage Department, Weifang Hospital of Traditional Chinese Medicine, Weifang Key Laboratory of Eco-textiles of Ministry of Education, College of Textiles and Clothing, Jiangnan University, Wuxi 214122, Jiangsu, China Key Laboratory of Marine Drugs Chinese Ministry of Education School of Medicine and Pharmacy Ocean University of China Qingdao 266003 P. R. China Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, P. R. China Cancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China Department of Pediatric Dentistry, Peking University School and Hospital of Stomatology, Beijing 100081, China. Department of Tumor Biological Treatment, The Third Affiliated Hospital of Soochow University, Jiangsu Changzhou 213003, China; Research Center for Cancer Immunotherapy Technology of Jiangsu Province, The Third Affiliated Hospital of Soochow University, Jiangsu Changzhou 213003, China Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases and State Key Laboratory of Natural Medicines, China Pharmaceutical University, 24 Tongjia Xiang, Nanjing 210009, China From the Department of Neurology (S.P., Q.L., J.L., H.L., B.X.), and National Clinical Research Center for Geriatric Disorders (S.P., Q.L., J.L., H.L., B.X.), Xiangya Hospital, Central South University, Changsha, Hunan, China. Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, China 4State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, Nankai University, Tianjin, China; 6State Key Laboratory of Elemento-Organic Chemistry, Institute of Elemento-Organic Chemistry, Collaborative Innovation Center of Chemical Science and Engineering, College of Chemistry, Nankai University, Tianjin, China CAS Key Laboratory of Molecular Nanostructure and Nanotechnology and Beijing National Laboratory for Molecular Sciences; Institute of Chemistry; Chinese Academy of Sciences (CAS); Beijing 100190; P. R. China Institute of Geriatric Medicine, Xiyuan Hospital of China Academy of Chinese Medical Sciences Stomatology Department Sichuan Provincial People's Hospital Chengdu China Department of Neurology, National Key Clinical Department and Key Discipline of Neurology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China Institute of Animal Genetics and Breeding, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China Critical Care Medical Center, Qingdao Women and Children’s Hospital, Qingdao University, Qingdao, China Department of Public Health and Preventive Medicine, School of Medicine, Jinan University , Guangzhou, China. 601 Huangpu Avenue West, Tianhe District, Guangzhou City, Guangdong Province Department of Radiation Oncology University of Texas MD Anderson Cancer Center Houston Texas Department of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou, China School of Nursing, Peking Union Medical College, Beijing, P.R. China Department of Ultrasound, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China. Department of Cardiology General Hospital of Northern Theater Command Shenyang China Department of Basic Medical Science, School of Medicine, Tsinghua University, Beijing 100084, China Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials, and Ministry of Education Key Laboratory for the Green Preparation and Application of Functional Materials, Hubei University, Wuhan 430062, PR China The State Key Laboratory of Anti-Infection Drug Development, HEC Pharma Group, Dong Guan 523871, China Sinovac Life Sciences Co., Ltd., Beijing, People’s Republic of China Department of Endocrinology and Metabolism West China Hospital of Sichuan University Key Laboratory for Organic Electronics & Information Displays and Jiangsu Key Laboratory for Biosensors, Institute of Advanced Materials, Jiangsu National Synergetic Innovation Centre for Advanced Materials, Nanjing University of Posts and Telecommunications, Nanjing 210023, China Department of Chemistry and Chemical Biology Rutgers University Piscataway NJ 08854 USA State Key Laboratory of Functional Materials for Informatics Shanghai Institute of Microsystem and Information Technology Chinese Academy of Sciences Shanghai 200050 China; Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of Sciences Beijing 100049 China Key Laboratory of Bioresources and Eco-Environment (Ministry of Education), College of Life Sciences, Sichuan University, Chengdu, Sichuan, China State Key Laboratory on Integrated Optoelectronics; Institute of Semiconductors; Chinese Academy of Sciences; P. R. China; College of Materials Science and Optoelectronic Technology Department of Mechanical Engineering, City University of Hong Kong, Hong Kong 999077, China Department of Endocrinology and Metabolism, Institute of Endocrinology, the First Affiliated Hospital, China Medical University, Liaoning Provincial Key Laboratory of Endocrine Diseases, Shenyang, China School of Environment and Civil Engineering, Jiangnan University, Wuxi 214122, China Department of Pharmacology, School of Pharmacy, Qingdao University, Qingdao, Shandong, China. College of Pharmacy and Traditional Chinese Medicine, Jiangsu College of Nursing, Huaian, Jiangsu 223005, China Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, People’s Republic of China Department of Chemistry, and System Science and Industrial Engineering State University of New York at Binghamton Binghamton NY 13902 USA Department of Anesthesiology, The Second Affiliated Hospital of Xi’an Medical University, Xi’an, Shaanxi, China Center for Reproductive Medicine, Cheeloo College of Medicine, Shandong University , Jinan, Shandong, China; Key Laboratory of Reproductive Endocrinology of Ministry of Education, Shandong University , Jinan, Shandong, China; Shandong Key Laboratory of Reproductive Medicine , Jinan, Shandong, China; Shandong Provincial Clinical Research Center for Reproductive Health , Jinan, Shandong, China; National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University , Jinan, Shandong, China Department of Chemistry and Chemical Biology; Rutgers University; Piscataway New Jersey 08854 USA Department of Evidence-Based Medicine and Clinical Epidemiology, West China Hospital, Sichuan University, Chengdu, China Department of Gastroenterology Peking University People's Hospital Beijing China Department of Data and Information, The Children's Hospital, Zhejiang University School of Medicine, Hangzhou, China; Sino-Finland Joint AI Laboratory for Child Health of Zhejiang Province, Hangzhou, China 5Department of Pharmacology and Pharmaceutical Sciences, School of Medicine, Tsinghua University, Beijing, China. NMPA Key Laboratory for Research and Evaluation of Pharmaceutical Preparations and Excipients State Key Laboratory of Natural Medicines Department of Pharmaceutics China Pharmaceutical University Nanjing 210009 China Department of Biochemistry and Molecular Biology, Harbin Medical University, Harbin, China The Department of TB Control, Shanghai Municipal Centers for Disease Control and Prevention, Shanghai 200336, China Department of Cardiology, Shenzhen Hospital, University of Chinese Academy of Sciences, Guangming District, Shenzhen, Guangdong Province, China The Research Institute of Pomology, Chinese Academy of Agricultural Sciences, Xingcheng 125100, China Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, 5 Yu-Shan Road, Qingdao 266003, China Department of Neonatology The First Affiliated Hospital of Zheng Zhou University Zhengzhou China Department of Surgery, Union Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan China Department of Cardiology, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116011, P.R. China Division of Cardiology, Xuanwu Hospital, Capital Medical University, Beijing, People’s Republic of China; Beijing Key Laboratory of Metabolic Disorder Related Cardiovascular Disease, Beijing, People’s Republic of China School of Integrated Chinese and Western Medicine Anhui University of Chinese Medicine Hefei China; Institute of Integrated Chinese and Western Medicine Anhui Academy of Chinese Medicine Hefei China The Key Laboratory of Chemical Metallurgy Engineering of Liaoning Province, University of Science and Technology Liaoning, Anshan, Liaoning Province 114051, China From the Department of Cardiology, Renmin Hospital of Wuhan University, China; School of Basic Medical Sciences and Medical Research Institute, School of Medicine, Wuhan University, China; and Institute of Model Animal of Wuhan University, China. Department of Ultrasound, Wuhan Asia General Hospital, Wuhan 430010, China College of Chemistry and Chemical Engineering, China University of Petroleum (East China), Qingdao 266580, People’s Republic of China Pharmaceutical Candidate Optimization, Research and Development, Bristol-Myers Squibb Company, Princeton, New Jersey 08540, United States Division of Rheumatology, University of California, San Francisco Shijiazhuang Posts and Telecommunications Technical College, Shijiazhuang, Hebei 050021, China Center for Research and Development of Fine Chemicals, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guizhou University, Guiyang 550025, P.R. China Department of Urology, Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou 450008, China Department of Neurology Xiangya Hospital, Central South University Changsha China; Key Laboratory of Neurology of Hunan Province, Central South University, Xiangya Hospital Changsha China School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan, Hubei 430074, PR China Department of Respiratory and Critical Care Medicine, Chongqing University Jiangjin Hospital, Chongqing 402260, P.R. China Department of Ophthalmology, Xin Hua Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China Photo-Electric Lab, Department of Precision Machinery and Precision Instrument, University of Science and Technology of China, Hefei 230027, China. Department of Nuclear Medicine, The Second Affiliated Hospital of Zhejiang University School of Medicine , 310009 Hangzhou , China State Key Laboratory of Marine Resource Utilization in South China Sea, Hainan Provincial Key Lab of Fine Chemistry, School of Chemical Engineering and Technology, Hainan University, Haikou 570228, China State Key Laboratory of Information Photonics and Optical Communications, Beijing University of Posts and Telecommunications, Beijing 100876, China Beijing Center for Disease Prevention and Control, No. 16, Hepingli Middle Street, Dongcheng District, Beijing 100013, China Division of Cardiology, Hospital for Sick Children, University of Toronto, Canada; From the Singapore Eye Research Institute, Singapore; the 2Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; College of Chemistry; Key Laboratory of Inorganic-Organic Hybrid Functional Material Chemistry; Ministry of Education; Tianjin Key Laboratory of Structure and Performance for Functional Molecules; Tianjin Normal University School of Food Science and Engineering Ocean University of China Qingdao China Department of Traditional Chinese Medicine, Shaanxi People's Hospital, Xi'an 710068, China. Department of Geriatrics, Department of Cardiac Surgery, and Department of Cardiology, Fujian Heart Disease Center, Fujian Medical University Union Hospital, Fuzhou, China (W.X., Q.Y., J.L., L.C., J.F., X.C., Y.Z., L.C., H.H.). Yunnan Key Laboratory for Wild Plant Resources Department of Economic Plants and Biotechnology Kunming Institute of Botany Chinese Academy of Sciences Kunming 650201 China State Key Laboratory of Traditional Chinese Medicine Resources in Southwest China, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China State Key Laboratory of Solid Lubrication; Lanzhou Institute of Chemical Physics; Chinese Academy of Sciences; Lanzhou; People's Republic of China Department of Cancer Epidemiology, Cancer Institute & Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York Thermo Fisher Scientific Shanghai 201206 China Key Laboratory of Synthetic and Self-Assembly Chemistry for Organic Functional Molecules, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China State Key Laboratory of Respiratory Disease, National Clinical Research Center of Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, China; Institute of Chinese Integrative Medicine, Guangzhou Medical University, Guangzhou, Guangdong, China Department of Pharmacy, the First Hospital Harbin Medical University 23 Youzheng Street, Nangang District Harbin 150001 China Department of Epidemiology and Biostatistics, School of Public Health, Tianjin Medical University, Tianjin 300070, China; Tianjin Key Laboratory of Environment, Nutrition and Public Health, Tianjin 300070, China; Tianjin Center for International Collaborative Research on Environment, Nutrition and Public Health, Tianjin 300070, China State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica Chinese Academy of Sciences 555 Zu Chong Zhi Road Shanghai 201203 P. R. China Department of Cell Biology, Harvard Medical School, Boston, MA 02115; Modern Research Center for Traditional Chinese Medicine Shanxi University Taiyuan China; The Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education Shanxi University Taiyuan PR China Beijing Institute of Nanoenergy and Nanosystems Chinese Academy of Sciences CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology (NCNST) Beijing 100083 P. R. China From the Department of Epidemiology (H.P., J.L., X.Z., C.Z., Z.Z., Y.H., M.Z., Y.Z.), School of Public Health, Medical College of Soochow University; Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases (H.P.); and Medical College of Soochow University (Y.F.), Suzhou, China. Department of Chemistry and Centre for Advanced 2D Materials (CA2DM) National University of Singapore 3 Science Drive 3 Singapore 117543 Singapore From the Singapore Eye Research Institute and the3Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; and the Laboratory of Controllable Nanopharmaceuticals, Chinese Academy of Sciences (CAS) Center for Excellence in Nanoscience and CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, 100190 Beijing, China Department of Respiratory and Critical Care Medicine, Chronic Airways Diseases Laboratory, Nanfang Hospital, Southern Medical University, Guangzhou, China Department of Chemistry Graduate School of Science Tohoku University Aza-Aoba, Aoba-ku Sendai 980-8578 Japan Faculty of Basic Science, Harbin Medical University, Harbin, China State Key Laboratory of Pathogens and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, PR China Singapore Eye Research Institute, The Academia, 20 College Road, Discovery Tower Level 6, Singapore 169856, Singapore; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, 1E Kent Ridge Road, NUHS Tower Block Level 7, Singapore 119228, Singapore; Department of Ophthalmology, Xin Hua Hospital, Shanghai Jiao Tong University School of Medicine, 1665 Kongjiang Road, Shanghai 200092, China Genomics Institute of the Novartis Research Foundation (GNF), 10675 John Jay Hopkins Drive, San Diego, California 92121, United States School of Chemistry, and Xi'an Key Laboratory of Sustainable Energy Materials Chemistry, Xi'an Jiaotong University, Xi'an 710049, P. R. China Department of Anesthesiology, New Jersey Medical School, Rutgers, The State University of New Jersey Newark, NJ 07103, USA. Center for Reproductive Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, China; Henan Province Key Laboratory of Reproduction and Genetics, Henan, China Department of Pharmacology, School of Norman Bethune Medical Sciences, Jilin University, Changchun, Jilin 130021, China Department of Physiology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. School of Marine Sciences, Sun Yat-sen University, Zhuhai 519082, P. R. China; Guangdong Provincial Key Laboratory of Marine Resources and Coastal Engineering, Zhuhai, China, 519082 State Key Laboratory of Molecular Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences; University of Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 200031, P.R. China Department of Oncology, First Affiliated Hospital, School of Medicine, Shihezi University, Xinjiang, P.R. China The Second Affiliated Hospital of Xi'an Jiaotong University State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, 38 Xueyuan Road, Beijing 100191, China Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. E-mail: 15622143848@163.com. Department of Cardiology, Intervention Cardiology Center Wuhan No.1 Hospital, No.215 Zhongshan Avenue, QiaoKou District Wuhan China Department of Clinical Laboratory, Shanxi Provincial Tuberculosis Hospital, Xi’an, People’s Republic of China College of Animal Science & Technology, Shihezi University, Shihezi, Xinjiang 832000, China. Hematology and Department of Critical Care Medicine, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, China School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine, Beijing 100029, China West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China; Department of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, UK State Key Laboratory of Petroleum Resources and Prospecting, China University of Petroleum (Beijing), Beijing 102249, China; Department of Chemical and Petroleum Engineering, University of Calgary, Calgary, Alberta T2N 1N4, Canada Department of Oncology, Xiangyang Central Hospital Affiliated Hospital of Hubei University of Arts and Science Xiangyang China Department of Chemistry, Tongji University, Shanghai, 200092, People's Republic of China Department of Cell Biology, Harvard Medical School, Boston, MA 02115 3 State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, China School of Psychology, Nanjing Normal University Department of Pharmacy The First Affiliated Hospital of Xinjiang Medical University Urumqi China College of Chemistry; Jilin University; Changchun 130012; China Key Laboratory of Environmentally Friendly Chemistry and Applications of Ministry of Education, College of Chemistry, Xiangtan University, Xiangtan, Hunan 411105, China School of Material Science and Engineering, Northeastern University, No. 11 Wenhua Road, Shenyang 110819, China; Foshan Graduate School of Innovation, Northeastern University, No. 2 Zhihui Road, Foshan 528311, China College of Life Science and Technology, Huazhong Agricultural University, Wuhan, Hubei 430070, China School of Food Science and Technology; Jiangnan University; Wuxi 214122 China; National Engineering Research Center for Functional Food; Jiangnan University; Wuxi 214122 China i-Lab, CAS Center for Excellence in Nanoscience, Suzhou Institute of Nano-Tech and Nano-Bionics (SINANO), Chinese Academy of Sciences, Suzhou 215123, P.R. China State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Ocular Surface Center, Sun Yat-sen University, Guangzhou, China Key Laboratory of Applied Surface and Colloid Chemistry (Ministry of Education), Key Laboratory for Macromolecular Science of Shaanxi Province, School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi’an 710119, P. R. China Linde+Robinson Laboratories, California Institute of Technology, Pasadena, California 91125, United States School of Public Health, Weifang Medical University, Weifang, Shandong Province, PR China Department of Public Health, Zhongshan Street Community Health Service Center, Shanghai, China Department of Chemistry; Tsinghua University; Beijing, China Department of Stomatology, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China (mainland) Department of Physiology, College of Basic Medicine, Xinjiang Medical University, Urumqi 830054, China. *Corresponding author, E-mail: lijing0527@163.com. International Flavors & Fragrances Inc., Research & Development 1515 State Highway 36, Union Beach, New Jersey 07735, United States College of Chemistry, Sichuan University, Chengdu 610064, People’s Republic of China State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, China; Collaborative Innovation Center of Chemical Science and Engineering, Nankai District, Tianjin 300071, China Affiliated Hospital of Changchun University of Chinese Medicine Changchun Jilin China Key Laboratory for Marine Drugs, Department of Pharmacy, State Key Laboratory of Oncogenes and Related Genes, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, People’s Republic of China Institute of Basic Medical Sciences and School of Basic Medicine, Center of Excellence in Tissue Engineering, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, P.R. China. Department of Pharmacy, Binzhou Medical University, Yantai, 264003, PR China Jiangsu Key Laboratory of Advanced Food Manufacturing Equipment & Technology School of Mechanical Engineering Jiangnan University Wuxi China State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, P. R. China Department of Cardiovasology, Second Xiangya Hospital,Central South University,Changsha 410011, China. Fuwai Hospital and Cardiovascular Institute, Chinese Academy of Medical Sciences, and Peking Medical Union College, Beijing, People’s Republic of China Department of Thoracic Surgery of General Hospital, Ningxia Medical University, Yinchuan, Ningxia 750004, China Tianjin Medical University Eye Hospital, Tianjin Medical University Eye Institute, College of Optometry and Ophthalmology, Tianjin Medical University, Fukang Rd. 251, Nankai District, Tianjin 300384, China Foshan Graduate School of Innovation, Northeastern University, Foshan 528311, China School of Materials and Chemistry, University of Shanghai for Science and Technology, Shanghai 200093, China Department of Radiology Hopp Children’s Cancer Center (KiTZ), 69120 Heidelberg, Germany; Division of Translational Pediatric Sarcoma Research, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), 69120 Heidelberg, Germany; National Center for Tumor Diseases (NCT), NCT Heidelberg, a Partnership between DKFZ and Heidelberg University Hospital, 69120 Heidelberg, Germany Sunshine Lake Pharma Co. Ltd, Dong Guan, China Department of Anesthesiology, the Second People Hospital of Dezhou, Dezhou, Shandong, Province, 253024, China Beijing National Laboratory for Molecular Sciences; CAS Key Laboratory of Molecular Recognition and Function; Institute of Chemistry; Chinese Academy of Sciences; Beijing 10090, China School of Public Health, Kunming Medical University, Kunming, Yunnan Province, China Department of Neurology, Second Hospital of Lanzhou University , Lanzhou , China State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, People's Republic of China, and Graduate School of the Chinese Academy of Sciences, Beijing 100039, People's Republic of China School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China Sinovac Life Sciences Co., Ltd., No. 21, Tianfu St., Daxing Biomedicine Industrial Base of Zhongguancun Science Park, Daxing District, Beijing 100050, China 9Department of Breast Medical Oncology, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China. Department of Physiology, Pre‐Clinical Science Guangxi Medical University Nanning 530021 China Department of Medicinal Chemistry; School of Pharmacy; Chongqing Medical University; Chongqing 400016; P. R. China Animal Quarantine Laboratory, Technology Center of Kunming Customs, Kunming 650200, China The Clinical Metabolomics Center China Pharmaceutical University Nanjing Jiangsu China Department of Ophthalmology, Central Hospital of Wuhan, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China Department of Chemistry and Chemical Biology, Rutgers University, 610 Taylor Road, Piscataway, New Jersey 08854, United States Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China Department of Anesthesia, Honghui Hospital, Xi'an Jiaotong University, Shaanxi, China. Heilongjiang Provincial Key Laboratory of Agricultural Microbiology, Northeast Agricultural University, Harbin 150030, China State Key Laboratory of High‐Efficiency Utilization of Coal and Green Chemical Engineering School of Chemistry and Chemical Engineering Ningxia University Yinchuan 750021 China Department of Neurology, The Third Affiliated Hospital of Xinxiang Medical University, Xinxiang, China. Department of Gastroenterology, Nanjing Children's Hospital, Nanjing Medical University, Nanjing 210008, China. State Key Laboratory of Pollutants Control and Pretreatment in Petroleum and Petrochemical Industry, Beijing, China; Department of Environment and Safety Engineering, China University of Petroleum (East China), Qingdao, China Shenyang Environment Monitor Central Station, Key Laboratory of Atmospheric Organic Compound Monitoring and Analysis, Ministry of Environmental Protection, Shenyang, People’s Republic of China Department of Urology, Affiliated Cancer Hospital and Institute of Guangzhou Medical University, Guangzhou, Guangdong 510095, P.R. China Institute of Biomechanics and Medical Engineering, School of Aerospace, Tsinghua University, Beijing 100084, People’s Republic of China School of Pharmacy, Hebei University of Chinese Medicine, Shijiazhuang 050200, China Key Laboratory for Molecular Genetic Mechanisms and Intervention Research on High Altitude Disease of Tibet Autonomous Region, School of Medicine Xizang Minzu University Xianyang China State Key Laboratory of Food Science and Technology Nanchang Univ. Nanchang 330047 Jiangxi China The College of Chemistry the State Key Laboratory of Elemento-Organic Chemistry Nankai University Wiejin Road 94# Tianjin 300071 P. R. China; Collaborative Innovation Center of Chemical Science and Engineering (Tianjin) Tianjin 300071 P. R. China National Clinical Research Center of Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, 167 Beilishi Road, Beijing 100037, China Institute of Virology and Biotechnology, Zhejiang Academy of Agricultural Sciences, 310021 Hangzhou, China; College of Basic Medical Sciences Dalian Medical University No. 9, West Segment of South Lvshun Road Dalian 116044 China National Engineering Laboratory for Modern Silk; College of Textile and Clothing Engineering; Soochow University; Suzhou 215123; China Botanical Review Team, Science Staff, Immediate Office, Office of Pharmaceutical Quality, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, MD, USA State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research Nankai University Tianjin P. R. China Department of Epidemiology, School of Public Health. State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210093, China; Institute for Research on Cancer and Aging, Nice (IRCAN), Nice, France Department of Neurology, The Fourth Affiliated Hospital of China Medical University, Shenyang, Liaoning, China (mainland) Department of Medical Imaging, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, China (mainland) Division of Evidence‐Based Medicine and Clinical Epidemiology West China Hospital of Sichuan University Chengdu Sichuan China Department of Hepatobiliary Surgery, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, P.R. China Center for Reproductive Medicine, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China; Key Laboratory of Reproductive Endocrinology, Shandong University, Ministry of Education, and National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Jinan, China School of Life Sciences, University of Science and Technology of China, Hefei 230026, China State Key Laboratory of Advanced Welding and Joining School of Materials Science and Engineering Harbin Institute of Technology (Shenzhen) Shenzhen 518055 China Spine Center Department of Orthopedics Changzheng Hospital Naval Medical University Shanghai 200003 China State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China; University of Chinese Academy of Sciences, Number 19A Yuquan Road, Beijing 100049, China NASA Ames Research Center, Moffett Field, California 94035, United States State Key Laboratory of Developmental Biology of Freshwater Fish & Key Laboratory of Protein Chemistry and Developmental Biology of the Ministry of Education, College of Life Science, Hunan Normal University, Changsha, Hunan, China. College of Food Science and Engineering, Jilin Agricultural University, Changchun, Jilin Province 130118, China; National Engineering Laboratory of Wheat and Corn Deep Processing, Changchun, Jilin Province 130118, China; Sports Health Technology College, Jilin Sports University, Jilin, China Department of Chemistry, Washington University, St. Louis, Missouri 63130, United States International Joint Cancer Institute Second Military Medical University Shanghai China Department of Pathology, Dalian Medical University, Dalian 116044, China Department of Neurological Surgery, State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Provincial Key Laboratory of Pharmaceutics, Guizhou Medical University, Guiyang, P R China; School of Pharmacy, Guizhou Medical University, Guiyang, P R China Department of Bioengineering, Rice University, Houston, TX 77030, USA. Department of Emergency Medicine, Center for Cardiovascular Research, University of Illinois Hospital and Health Sciences System, Chicago, IL 60612, USA Department of Pharmacognosy and National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, University, Mississippi 38677 Department of Gastroenterology, Tongji Hospital, Tongji University, Shanghai 200065, China Faculty of Life Science College, Southwest Forestry University, Kunming, Yunnan, China Institute of Clinical Pharmacology, Zhengzhou University, Zhengzhou, Henan, China Department of Research and Development GenePlus‐Beijing Beijing 102206 P. R. China Department of Radiation Oncology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China Department of Plastic, Second Affiliated Hospital, Air Force Medical University, Xi’an, Shaanxi 710038, China Department of Ophthalmology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China Department of Information Management, School of Economics and Management, Beijing Jiaotong University, Beijing 100044, China. From the Department of Tissue Engineering, Beijing Institute of Basic Medical Sciences and Tissue Engineering Research Center, Academy of Military Medical Sciences, Beijing, People’s Republic of China (X.G., Y.Z., H.C., C.W., L.E., X.Z., C.D., L.D., H.J., J.L., Y.S., X.Y.); Xytex Research, Augusta, Ga (Y.S.); Department of Surgery and Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta (Y.S.); and Center for Regenerative Biology, University of Connecticut, Storrs (X.Y.). Tianjin Key Laboratory for Modern Drug Delivery and High Efficiency, School of Pharmaceutical Science and Technology Tianjin University Tianjin China; Key Laboratory of Systems Bioengineering, Ministry of Education Tianjin University Tianjin China Department of Biochemistry and Molecular Biology From Genomics and Oncology Research, Roche Molecular Systems, Inc, Pleasanton, California. Pharmacology Core, Karmanos Cancer Institute, Wayne State University, Detroit, MI, USA School of Agriculture and Biology Shanghai Jiao Tong University 800 Dongchuan Road, Minhang District Shanghai 200240 China Single-Cell Center, CAS Key Laboratory of Biofuels and Shandong Key Laboratory of Energy Genetics, Qingdao Institute of BioEnergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao, Shandong 266101, China; University of Chinese Academy of Sciences, Beijing 100049, China College of Pharmacy, Southwest University for Nationalities, Chengdu, Sichuan, P.R. China Department of Emergency, Nanxishan Hospital of Guangxi Zhuang Autonomous Region, Guilin 541002, Guangxi Zhuang Autonomous Region, China. Center for Integrated Protein Science at the Department Chemie, Technische Universität München, Lichtenbergstrasse 4, D-85747 Garching, Germany Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.; Amgen Research, Thousand Oaks, CA 91320, USA. College of Pharmacy Tianjin Key Laboratory of Molecular Drug Research Nankai University Tianjin 300353 P. R. China Key Laboratory of Advanced Synthetic Chemistry (Yunnan Minzu University) of State Ethnic Affairs Commission, Key Laboratory of Green-chemistry Materials in University of Yunnan Province, School of Chemistry & Environment, Yunnan Minzu University, Kunming, 650500, P. R. China Key Laboratory of Marine Drugs, Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao, P. R. China Department of Vascular Anomalies and Interventional Radiology, Jinan, Shandong 250022, P.R. China Department of Clinical Laboratory The Third Affiliated Hospital of Zhengzhou University Zhengzhou China Department of Gastroenterology, Jiaozuo Renmin Hospital, Jiaozuo, P.R. China Harbin Medical University, School of Public Health, Harbin 150081, China. School of Chemistry and Chemical Engineering Anhui University Hefei 230601 P. R. China College of Veterinary Medicine China Agricultural University Beijing China National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China;; University of Chinese Academy of Sciences, Beijing 100049, China; School of Industrial and Systems Engineering Georgia Institute of Technology Atlanta GA USA Central Laboratory, Southern Medical University, Guangzhou 510515, China Key Laboratory of Plant-microbe Collaboration Research, School of Biological and Environmental Engineering, Xi'an University, Xi'an 710065, China. Department of Environmental Health, School of Public Health, China Medical University, Shenyang, People's Republic of China Department of Emergency Medicine, Center for Advanced Resuscitation Medicine, University of Illinois Hospital & Health Sciences System, Chicago, IL 60612, USA Department of Hematology, Hebei Province Hospital of Chinese Medicine, Shijiazhuang, Hebei Province, China Assistant professor in the Comparative Health Outcomes, Policy, and Economics Institute and in the Department of Pharmacy in the School of Pharmacy at the University of Washington in Seattle. Hematology Department, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, People’s Republic of China; Key Laboratory of Hematology, Education Department of Guangxi Zhuang Autonomous Region, Guangxi Medical University, Nanning, Guangxi, People’s Republic of China State Key Laboratory of Natural Medicines, Department of Pharmaceutics, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, China Department of Pathogenic Biology School of Basic Medical Science Shandong University Department of Neonatology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China Department of Neurology The Second Affiliated Hospital of Dalian Medical University Dalian China 4The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland; and Department of Infectious Diseases Huai‐An Fourth People's Hospital Jiangsu China The Martin Boyer Laboratories, Gastroenterology Section, Department of Medicine, The University of Chicago, IL 60637, USA. From the Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, United Kingdom (H.V., N.Y.Y., A.S., H.I., N.H., A.M.N.W., A.S., N.M., S.G., P. Shah, P. Sukumar, K.E.P., P.J.G., J.L., D.J.B., S.B.W., R.M.C., M.T.K.); Division of Medicine, Department of Metabolism & Experimental Therapeutics, University College London, United Kingdom (M.C.G.); and British Heart Foundation Centre of Research Excellence, King’s College London, United Kingdom (A.M.S., C.X.C.S.). Key Laboratory for Subtropical Wetland Ecosystem Research of MOE, College of the Environment and Ecology, Xiamen University , Xiang'an South Road, Xiamen, Fujian 361005 , P.R. China Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801 Institute of Applied Electronics, China Academy of Engineering Physics (CAEP), Mianyang, China Department of Dermatology, Henan Province Hospital of Traditional Chinese Medicine, The Second Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou 450002, People's Republic of China School of Public Health, Nanjing Medical University, Nanjing, China Department of Ophthalmology, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China; Future Medical Laboratory, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China College of Storage and Architecture Engineering, China University of Petroleum, Qingdao 266555, China. jingli@upc.edu.cn College of Life Sciences, Yan’an University, Yan’an 716000, PR China State Key Laboratory of Electroanalytical Chemistry; Changchun Institute of Applied Chemistry; Chinese Academy of Sciences; Changchun; P. R. China Department of Automotive Engineering; School of Transportation Science and Engineering; Beihang University; Beijing; China State Key Laboratory and Institute of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, China; Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Weijin Road #94, Nankai District, Tianjin 300071, China Department of Rheumatology Jiangsu University Affiliated Hospital Zhenjiang China Department of Interventional Radiology, First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, China Department of Pharmacology, College of Basic Medical Science, Jilin University Department of Gastroenterology, The First Affiliated Hospital of Liaoning Medical University, Jinzhou, China Key Laboratory for Biotechnology on Medicinal Plants of Province, School of Life Science, Xuzhou Normal University, Xuzhou 221116, China School of Medicine, South China University of Technology, Guangzhou 510006, China Department of Environment and Health; Tianjin Institute of Health and Environmental Medicine; Key Laboratory of Risk Assessment and Control for Environment & Food Safety; Tianjin 300050; China School of Life Sciences; Key Laboratory of Preclinical Study for New Drugs of Gansu Province; School of Basic Medical Sciences; Lanzhou University; Lanzhou Research Institute of Pomology of CAAS, Xingcheng 125100, China State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Collaborative Innovation Center of Advanced Microstructures, Nanjing University, Nanjing 210046, People’s Republic of China Department of Molecular Biophysics and Biochemistry, Yale University, 333 Cedar Street, New Haven, Connecticut 06520 Department of Pathogenic Biology Shandong University School of Medicine Jinan Shandong China Key Laboratory of Resource Biology and Biotechnology in Western China (Northwest University), Ministry of Education, Xi’an 710069, China VIP Cardiovascular Department, the Sixth Medical Center of Chinese PLA General Hospital, Beijing, China. Department of Orthopedics, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China College of Urban and Rural Construction, Shaoyang University, Shaoyang, Hunan, China Department of Digestion, The First Hospital of Handan City, Handan, Hebei 056002, P.R. China Orthopaedic Department, Xi Jing Hospital Affiliated to the Air Force Medical University of PLA, Xi'an, China Department of Radiology Beijing Friendship Hospital, Capital Medical University Beijing China Department of Hepatobiliary Surgery, Xinqiao Hospital, Army Medical University, Chongqing 400037, P.R. China National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China; Graduate University of Chinese Academy of Sciences, Beijing, 100049, China Department of Endocrinology and Metabolism, The Institute of Endocrinology, NHC Key Laboratory of Diagnosis and Treatment of Thyroid Disease, The First Hospital of China Medical University, Shenyang, China. Millennium Pharmaceuticals, Inc., 40 Landsdowne Street, Cambridge, Massachusetts 02139, United States College of Food Science & Technology Huazhong Agricultural University Wuhan Hubei China Department of Hematology/Oncology, Shanghai Children's Medical Center, School of Medicine Shanghai Jiao Tong University Shanghai China; Department of Pediatric Henan Provincial People's Hospital Zhengzhou China Key Laboratory of Optoelectronic Technology and System of Ministry of Education, College of Optoelectronic Engineering, Chongqing University, Chongqing400044, People’s Republic of China Department of Chemistry, Southern University of Science and Technology, Shenzhen 518055, China School of Basic Sciences, ChangChun University of Technology, A1018 Huguang Road, Changchun 130012, China Weifang Hospital of Traditional Chinese Medicine, Weifang Department of Nutrition and Food Hygiene, College of Public Health, Qingdao University, Ning Xia Road 308, Qingdao 266071, China State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, China State Key Laboratory of Food Science and Technology Nanchang University Nanchang 330047 China Department of Biopharmaceutical Sciences Harbin Medical University Daqing Heilongjiang China; Department of Biopharmaceutical Key Laboratory of Heilongjiang Province Harbin Medical University Harbin Heilongjiang China Joint National Laboratory for Antibody Drug Engineering, Henan International Union Laboratory of Antibody Medicine, Department of Cell Biology and Genetics, Henan University School of Medicine, Kaifeng, China. From the National Clinical Research Center of Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing (X.L., J.L., S.H., L.J.); Yale School of Medicine (K.M., Y.W., N.S.D., H.M.K.) and Yale School of Public Health (H.M.K.), Yale University, New Haven, CT; Center for Outcomes Research and Evaluation, Yale New Haven Hospital, CT (K.M., Y.W., N.S.D.... State Key Laboratory of Marine Resource Utilization in South China Sea, Hainan Provincial Key Lab of Fine Chemistry School of Chemical Engineering and Technology Hainan University Haikou 570228 P. R. China State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China; School of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei 230026, China Multidisciplinary Cardiovascular Research Centre University of Leeds Leeds UK; Faculty of Biological Sciences University of Leeds Leeds UK Center for Functional Nanomaterials, Brookhaven National Laboratory, Upton, NY 11973, USA. Department of Biochemistry and Molecular Biology, College of Basic Medical Sciences, Second Military Medical University, Shanghai, People’s Republic of China; 1 Department of Electrical Engineering & Computer Science, Case Western Reserve University, Cleveland, OH 44106, USA and 2Joint Institute of Systems Biology, College of Computer Science & Technology, Jilin University, Changchun, Jilin Province, 130012, China; 1 Department of Electrical Engineering & Computer Science, Case Western Reserve University, Cleveland, OH 44106, USA and 2Joint Institute of Systems Biology, College of Computer Science & Technology, Jilin University, Changchun, Jilin Province, 130012, China Sichuan Center for Disease Control and Prevention, Chengdu, Sichuan, China. Department of Integrated Traditional Chinese and Western Medicine, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China Department of Anesthesiology, Qilu Hospital of Shandong University (Qingdao), Qingdao, P.R. China College of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, PR China Medical College, University of Jinan, Jinan, China Wayne State University Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, 1 Xian Nong Tan Street, Beijing 100050, P. R. China Key Laboratory for Space Bioscience and Space Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi’an, Shaanxi, P. R. China; Jiangsu Key Laboratory of Engineering Mechanics, Southeast University, Nanjing 210096, China Department of Scientific Research Center, China-Japan Union Hospital of Jilin University, Changchun 130000, Jilin, China Key Laboratory of Bio-inspired Smart Interfacial Science and Technology of Ministry of Education, School of Chemistry, Beihang University, Beijing 100191, P. R. China Department of Neonatology, Affiliated Hangzhou First People’s Hospital, Zhejiang University School of Medicine, Hangzhou City, China Department of Echocardiography and Vascular Ultrasound Center, The First Affiliated Hospital, School of Medicine Zhejiang University Hangzhou Zhejiang Province China Key Laboratory of New Low-Carbon Green Chemical Technology, Education Department of Guangxi Zhuang Autonomous Region, Guangxi Key Laboratory of Clean Pulp & Papermaking and Pollution Control, School of Chemistry and Chemical Engineering, School of Light Industry and Food Engineering, Guangxi University, Nanning 530004, China State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, P.R. China Contribution from the Department of Process Research, Merck Research Laboratories, P.O. Box 2000, Rahway, New Jersey 07065 Hunan Cancer Hospital, and the Affiliated Cancer Hospital of Xiangya Medical School, Central South University, Changsha, China; Medical Department of Breast Cancer, Hunan Cancer Hospital, Changsha, China; Department of Breast Cancer Medical Oncology, the Affiliated Cancer Hospital of Xiangya Medical School, Central South University, Changsha, China Department of Pharmacy, the Affiliated Hospital of Qingdao University, Qingdao, PR China; Department of Pharmacology, ‡Cancer Therapy & Research Center, and §Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, United States Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, 410008 P. R. China. Department of Hepatobiliary Surgery, Second Affiliated Hospital of Third Military Medical University, Chongqing 400037, China School of Pharmaceutical Sciences, National Demonstration Center for Experimental Ethnopharmacology Education, South-Central University for Nationalities, Wuhan 430074, China Wuhan National High Magnetic Field Center & School of Physics; Huazhong University of Science and Technology; Wuhan; P. R. China Department of Pediatrics, China Medical University affiliated with Shengjing Hospital, Shenyang, 110004 Liaoning, China Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, IL 60637 State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin, China Institute of Food Science and Engineering, School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, People’s Republic of China Section of Comprehensive Lymphoma, Department of Internal Medicine, Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou, Henan 450008, P.R. China Department of Hepatic Surgery I Eastern Hepatobiliary Surgery Hospital Shanghai China Department of Rheumatology and Immunology Peking University People's Hospital Beijing China National Clinical Research Center of Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, People’s Republic of China Institute of NBC Defense of PLA, Beijing, China Anhui Province Key Laboratory of Chinese Medicinal Formula, Anhui University of Chinese Medicine,Hefei 230012,China Key Laboratory for Advanced Materials and Institute of Fine Chemicals School of Chemistry&Molecular Engineering East China University of Science and Technology 130 Mei Long Road Shanghai 200237 China School of Marine Science and Engineering State Key Laboratory of Marine Resource Utilization in South China Sea Hainan University Haikou 570228 China Department of Radiology and Medical Imaging, University of Virginia, Charlottesville, Virginia Key Laboratory for the Green Preparation and Application of Functional Materials Hubei Key Laboratory of Polymer Materials School of Materials Science and Engineering Hubei University Wuhan 430062 China Alnylam Pharmaceuticals Inc., Cambridge, MA 02142, USA Chongqing Institute of Green and Intelligent Technology, Chinese Academy of Sciences, Chongqing 400714, China The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Hunan Cancer Hospital, Changsha 410000, China; Department of Breast Cancer Medical Oncology, Hunan Cancer Hospital, Changsha 410000, China Department of Urology The Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital Zhengzhou Henan China Department of Pediatric Intensive Care Unit, Qingdao Women and Children's Hospital, Qingdao, Shandong 266000, China. lisang1976@aliyun.com. School of Public Health and Family Medicine, Capital Medical University, Beijing 100069, China. Department of Hematology, Tianjin Medical University General HospitalTianjin 300052, China; Department of Hematology, Shangyu People's HospitalShangyu 312300, Shaoxing, Zhejiang, China. Department of Mathematics, Pennsylvania State University, University Park, State College, PA 16802, USA Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University College of Veterinary Medicine, Yangzhou, Jiangsu 225009, China Jiangsu Key Lab of Biomass-based Green Fuels and Chemicals; College of Chemical Engineering; Nanjing Forestry University; Nanjing 210037; China School of Chemistry and Chemical Engineering; Yantai University; 264005 Yantai; China Department of Pharmacy, Gansu Gem Flower Hospital, Lanzhou, China. State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun, Jilin 130022, China Department of Internal Medicine, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China. College of Basic Medical Sciences; Jilin University; Changchun; China Department of Chemistry; College of Science; Huazhong Agricultural University; Wuhan 430070; China State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Research Unit of Oral Carcinogenesis and Management Chinese Academy of Medical Sciences, West China Hospital of Stomatology, Sichuan University Chengdu China Key Laboratory for Polymeric Composite and Functional Materials of Ministry of Education Key Laboratory of High-Performance Polymer-based Composites of Guangdong Province School of Chemistry Sun Yat-Sen University Guangzhou China Nephropathy Department China‐Japan Friendship Hospital Beijing China Department of Oral and Maxillofacial Surgery Peking University School and Hospital of Stomatology Beijing P. R. China Department of Thoracic Surgery, General Hospital, Ningxia Medical University, Yinchuan, Ningxia, China Department of Endocrinology and Metabolism and Institute of Endocrinology, NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, First Hospital of China Medical University , Shenyang, China Shandong Provincial Key Laboratory of Chemical Energy Storage and Novel Cell Technology, College of Chemistry and Chemical Engineering, Liaocheng University, Liaocheng, Shandong, 252059, P. R. China School of Public Health, Hangzhou Normal University Hangzhou 311121, China Trauma Center/National Center for Trauma Medicine/Key Laboratory of Trauma Treatment and Neural Regeneration (Peking University), People's Hospital, Peking University Beijing 100044, China. Department of plastic and Burn Surgery, Tangdu Hospital, Forth Military Medical University, Xi'an, China C School of Materials and Chemical Engineering, Xuzhou University of Technology, Xuzhou 221018, PR China State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun 130012, People’s Republic of China BGI-Shenzhen, Shenzhen 518083, China; China National GeneBank, BGI-Shenzhen, Shenzhen 518120, China 1Department of Oncology, Wayne State University School of Medicine, and the Barbara Ann Karmanos Cancer Institute, Detroit, Michigan. From the Department of Physiology and Functional Genomics (J.L., E.M.R., M.K.R.), University of Florida College of Medicine, Gainesville, Florida. Physical Chemistry I; Department of Chemistry and Pharmacy; University of Erlangen-Nürnberg; 91058 Erlangen, Germany Center for Translational Medicine, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, P. R. China State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Wuhan 430070, PR China Department of Geriatrics Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences Beijing China Department of Ophthalmology, Xinhua Hospital, Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China Department of Animals Sciences College of Animal Sciences Jilin University Changchun China College of Life Sciences, Capital Normal University, Beijing 100048, China Department of Cardiology, Xuanwu Hospital, Capital Medical University, Beijing, China State Key Lab of Electroanalytical Chemistry Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 China State Key Laboratory of Chemical Engineering Department of Chemical Engineering Tsinghua University Beijing 100084 China Key Laboratory of Luminescence Analysis and Molecular Sensing (Southwest University), Ministry of Education, College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, China Department of Oncology Tongji Hospital Huazhong University of Science and Technology Wuhan Hubei Province China School of Computing, Informatics, and Decision Systems Engineering, Arizona State University Phoenix AZ USA Department of Stomatology, Beijing Friendship Hospital, Capital Medical University, Beijing, China. Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, United States The Comparative Health Outcomes, Policy, and Economics Institute, Department of Pharmacy, University of Washington, Seattle State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200032, China Centre for Bioengineering and Biotechnology, China University of Petroleum (East China), Qingdao 266555, China Sports Center, Xi’an Jiaotong University, Xi’an, Shaanxi 710049, China Harvard University, Harvard School of Public Health, 401 Park Dr, Landmark Center West, 404N, Boston, MA 02215 Department of Pathology, Shantou University Medical College, Shantou, Guangdong, China Dongzhimen Hospital, Beijing University of Chinese Medicine, No. 5 Hai Yun Cang, Dongcheng District, Beijing 100700, China Department of Radiology, Affiliated Zhongshan Hospital of Dalian University, Dalian, Liaoning, China;; Medical Imaging Center, Central Hospital of Shaoyang, Shaoyang, Hunan, China; Key Laboratory of Organic Optoelectronics and Molecular Engineering of Ministry of Education Chemistry Department Tsinghua University Beijing 100084 China Key Laboratory of Ecosystem Network Observation and Modeling, Institute of Geographic Sciences and Natural Resources Research, Chinese Academy of Sciences, Beijing 100101, China Discovery Process Chemistry, Merck & Co., Inc., West Point, Pennsylvania 19486, United States Amsterdam UMC Location Vrije Universiteit Amsterdam, Medical Oncology, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands; Cancer Center Amsterdam, Cancer Biology and Immunology, Amsterdam, The Netherlands School of Life Science and Technology ShanghaiTech University Shanghai China Key Laboratory of Green Chemistry & Technology of Ministry of Education College of Chemistry Sichuan University 29 Wangjiang Road Chengdu 610064 P. R. China Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu From the Division of Gynecologic Oncology; Division of Human Gene Therapy, Departments of Medicine, Pathology, Surgery, Obstetrics and Gynecology, and Gene Therapy; Laboratory of Multimodality Imaging; and Department of Pathology, University of Alabama at Birmingham, Birmingham, AL. Department of Applied Chemistry; China Agricultural University; Beijing 100193, China Authors' Affiliations: 1Prostate Cancer Discovery and Development Program; Departments of 2Cancer Biology and 3Pathology, Thomas Jefferson University, Philadelphia, Pennsylvania; Department of 4Cell Biology, 5Radiation Oncology, 6Pathology, and 7Orthopedics, University of Massachusetts Medical School, Worcester; 8Biogen Idec, Inc., Cambridge, Massachusetts; and 9Department of Biochemistry, The University of Vermont, Burlington, Vermont; Authors' Affiliations: 1Prostate Cancer Discovery and Development Program; Departments of 2Cancer Biology and 3Pathology, Thomas Jefferson University, Philadelphia, Pennsylvania; Department of 4Cell Biology, 5Radiation Oncology, 6Pathology, and 7Orthopedics, University of Massachusetts Medical School, Worcester; 8Biogen Idec, Inc., Cambridge, Massachusetts; and 9Department of Biochemistry, The University of Vermont, Burlington, Vermont College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, People's Republic of China Laboratory of Tumor Biology The Second Clinical College of Guangzhou University of Chinese Medicine Guangzhou China; Department of Human Resource The Second Clinical College of Guangzhou University of Chinese Medicine Guangzhou China Women's Health Research Center, University of Mississippi Medical Center, Jackson, Mississippi;; Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi; and Department of Laboratory Medicine, Panzhihua Central Hospital, Panzhihua, Sichuan, China Center for Infectious Disease Research, Department of Basic Medical Science, School of Medicine, Tsinghua University, Beijing 100084, China Key Laboratory of Environmental Pollution and Microecology of Liaoning Province, Shenyang Medical College, Huanggu, Shenyang City, Liaoning Province 110034, P. R. China Department of Clinical Laboratory Center, The Second Hospital of Lanzhou University, Lanzhou, Gansu, 730000, China Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, School of Pharmaceutical Sciences, Wuhan University, Wuhan, China Department of Orthodontics, Peking University School and Hospital of Stomatology, Beijing, China National Pain Diagnosis Centre, China‐Japan Friendship Hospital Beijing P.R. China Department of Cardiovascular Surgery, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, China State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116012, China Department of Medicine, University of Chicago, Chicago, IL 60637 Departments of Neuroscience, Anatomy, Histology, and Embryology, Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University, Lanzhou, PR China; Departments of Anatomy, Histology, and Embryology, School of Basic Medical Sciences, Gansu University of Chinese Medicine, Lanzhou, PR China Key Laboratory of Bioresources and Ecoenvironment (Ministry of Education), College of Life Sciences, Sichuan University, Chengdu 610064, People's Republic of China Department of Oncology, Guangzhou General Hospital of Guangzhou Command, Guangzhou 510010, China. School of Forensic Medicine, Southern Medical University The First Affiliated Hospital of Zhengzhou University, 1 Jianshe East Road, Zhengzhou, Henan, P.R. China Yangtze River Pharmaceutical Group Beijing Haiyan Pharmaceutical Co., Ltd 2 Institute of Biopharmaceutical Research, , Beijing 102206, China Huzhou Center for Disease Control and Prevention, Huzhou, Zhejiang, China Aviation and Nautical Medical Center, Navy General Hospital, No. 6 Fucheng Road, Haidian District, Beijing 100048, China State Key Laboratory Breeding Base for Zhejiang Sustainable Pest and Disease Control, Key Laboratory of Plant Protection and Biotechnology, MOA and Zhejiang Province, Institute of Virology and Biotechnology, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, PR China Radiotherapy Center, The First People's Hospital of Chenzhou, Xiangnan University, Chenzhou 423000, China. Division of Cardiovascular Surgery, The Hospital for Sick Children, Toronto, ON, Canada.; Department of Surgery, University of Toronto, Toronto, ON, Canada. Ministry of Education, Key Laboratory of Resource Biology and Biotechnology in Western China (Northwest University), Xi’an 710069, China; Biomedicine Key Laboratory of Shaanxi Province, College of Life Sciences, Northwest University, Xi’an 710069, China Sichuan Agricultural University, China Key Laboratory of Environment Correlative Dietology, Ministry of Education, Huazhong Agricultural University, Wuhan, Hubei 430070, People’s Republic of China Department of Ultrasound, Nuclear Industry 215 Hospital of Shanxi Province, Xianyang, Shanxi 712000, P.R. China College of Food Science and Engineering, Ocean University of China, Qingdao 266003, China State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center , Guangzhou , China; Department of Radiology, Sun Yat-Sen University Cancer Center , Guangzhou , China The Fist Ward, Department of Pulmonary and Critical Care Medicine, The Second Affiliated Hospital of Kunming Medical University, Kunming, 650101, China School of Chemical and Biological Engineering Lanzhou Jiaotong University Lanzhou China Center of Infectious Diseases, Tangdu Hospital, Fourth Military Medical University, Xi’an 710038, China State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China Tongji School of Pharmacy; Huazhong University of Science and Technology; Wuhan China Key Laboratory of Synthetic and Self-Assembly Chemistry for Organic Functional Molecules, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China Key Laboratory of Tobacco Chemistry of Yunnan Province, China Tobacco Yunnan Industrial Co., Ltd, Kunming 650231, China Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Center of Excellence in Tissue Engineering, Chinese Academy of Medical Sciences; Beijing Key Laboratory of New Drug Development and Clinical Trial of Stem Cell Therapy (BZ0381), P.R. China Center for Biophysics and Computational Biology, Department of Biochemistry, and Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana–Champaign, Urbana, IL 61801 Department of Orthopaedic Surgery Xijing Hospital, The Air Force Medical University Xi'an China Université Grenoble Alpes, INAC-SPMM, F-38000 Grenoble, France; CEA, INAC-SPMM, F-38054 Grenoble, France Department of MRI, Affiliated Hospital, Logistics University of Chinese People's Armed Police Forces, Tianjin 300162, China. Corresponding author: Wang Yongqiang, Email: yongqiangwang1962@sina.com. Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, P. R. China Cell Therapy Laboratory, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, China; Department of Immunology, Basic Medical College, Hebei Medical University, Shijiazhuang, Hebei 050017, China Institute of Human Virology, University of Maryland School of Medicine, 725 West Lombard Street, Baltimore, MD 21201; Department of Hematology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China (mainland) Department of General Medicine, Sichuan Cancer Hospital & Institute, Chengdu 610041, Sichuan Province, China Program in Advanced Resuscitation Medicine, Department of Emergency Medicine, Center for Cardiovascular Research, University of Illinois Hospital & Health Sciences System, Chicago, Illinois; Department of Respiratory & Critical Care Medicine, Peking University People's Hospital, Beijing 100044, China. Department of Clinical Laboratory First Affiliated Hospital of Kunming Medical University Kunming China; Yunnan Institute of Diagnosis Kunming China; Yunnan Key Laboratory of Laboratory Medicine Kunming China Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany Department of Neurology and Center for Clinical Neuroscience, Daping Hospital, Third Military Medical University, Chongqing, China. School of Pharmacy and ‡School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, Wuhan University School of Pharmaceutical Sciences, Wuhan University, Wuhan 430000, Hubei, People’s Republic of China From the Multidisciplinary Cardiovascular Research Centre (J.L., R.M.C., L.A.W., M.S.A., L.M., B.H., Y.M., S.T., V.A.L.S., H.T., M.S., K.E.P., M.T.K., D.J.B.), Faculty of Biological Sciences (J.L., L.A.W., M.S.A., L.M., B.H., Y.M., S.T., V.A.L.S., H.T., M.S., D.J.B.), Faculty of Medicine & Health (R.M.C., K.E.P., M.T.K.), and School of Chemistry (R.F.), University of Leeds, United Kingdom; Clinical Physiology Department (M.S.A.), Faculty of Medicine, Menoufiya University, Egypt; and Department... Center for Drug Discovery and Departments of Chemistry and Chemical Biology and Pharmaceutical Sciences, Northeastern University, Boston, Massachusetts 02115, United States for the GDLM group Molecular Oncology, Centro Nacional de Investigaciones Oncológicas (CNIO), 28029 Madrid, Spain; Department of Rheumatology, Peking Union Medical College Hospital (PUMCH), Chinese Academy of Medical Sciences, National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID) , Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education , Chinese Rheumatism Data Center (CRDC) , Beijing , China State Key Laboratory of Food Nutrition and Safety, Tianjin University of Science and Technology, Tianjin 300457, China Clinical Laboratory Center, The Affiliated Hospital of Guizhou Medical University, Guiyang 550004, China School of Basic Sciences & Advanced Institute of Materials Science; Changchun University of Technology; Changchun, P.R. China Department of Statistics, Iowa State University, Ames, Iowa. Huzhou Center for Disease Control and Prevention, 999 Changxing Road, Huzhou 313000, Zhejiang Province, China School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Shenzhen 518107, P. R. China Department of Respiratory Disease, Research Institute of Surgery, Daping Hospital, the Third Military Medical University, Chongqing, China Pediatric Apartment, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China Department of Pharmacy Xiangya Hospital of Central South University Central South University Changsha Hunan 410008 P. R. China From the Department of Cardiology, Institute of Heart and Vascular Diseases (J.L.), Second Affiliated Hospital of Dalian Medical University, China grid.412243.2 0000000417601136 College of Animal Science and Technology Northeast Agricultural University 59 Mucai Street, Xiangfang District 150030 Harbin China CAS Key Laboratory of Soft Matter Chemistry; Hefei National Laboratory for Physical Sciences at Microscale and Department of Chemistry; University of Science and Technology of China; Hefei; P. R. China Department of Pharmacology (The Key Laboratory of Cardiovascular Research, Ministry of Education) at College of Pharmacy, Harbin Medical University, Harbin, Heilongjiang Province, China Tianjin Eye Hospital, Tianjin Institute of Ophthalmology, Tianjin Ophthalmology and Visual Development Key Laboratory, Tianjin Medical University, Tianjin 300020, China. Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center , Houston, TX, USA From the Singapore Eye Research Institute, Singapore; and the2Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. Department of Biochemistry University of Texas, Southwestern Medical Center at Dallas Dallas, TX 75390-9038 (USA). College of Resources and Information, China University of Petroleum, Qingdao 266555, China. jingli@upc.edu.cn School of Life Sciences, Northwestern Polytechnical University, Xi’an, Shaanxi 710072, PR China; Research Center of Special Environmental Biomechanics & Medical Engineering, Northwestern Polytechnical University, Xi’an, Shaanxi 710072, PR China; Bioinspired Engineering & Biomechanics Center (BEBC), Xi’an Jiaotong University, Xi’an 710049, PR China; Key Laboratory on Space Physics and Chemistry of Ministry of Education and Key Laboratory on Macromolecular Science & Technology of Shanxi Province, Department of Applied Chemistry, School of Science, Northwestern Polytechnical University, 710072, P.R China School of Materials Science and Engineering, Shanghai University of Engineering Science, Shanghai 201620, China Department of Respiration, Shenzhen Children’s Hospital, Shenzhen, Guangdong, China (mainland) School of Chemistry and Chemical Engineering Chongqing University Daxuecheng South Road 55 Chongqing 401331 China NHC Key Laboratory of Hormones and Development Chu Hsien‐I Memorial Hospital and Tianjin Institute of Endocrinology, Tianjin Medical University Tianjin China; Tianjin Key Laboratory of Metabolic Diseases Tianjin Medical University Tianjin China College of Life Sciences, Hebei Normal University, Shijiazhuang 050024, Hebei, China. Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China. College of Life Science; Shanghai Normal University; Shanghai 220234; China; College of Pharmacy Department of Neurology, The 923th Hospital of People's Liberation Army, Nanning, China. Department of Oncology; Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology; Hubei Province China Department of Medical Oncology, First Affiliated Hospital of Medical College of Shihezi University, Shihezi 832000, China Program in Advanced Resuscitation Medicine, Center for Cardiovascular Research, and Department of Emergency Medicine, University of Illinois Hospital & Health Sciences System, Chicago, Illinois; National Institute for Communicable Disease Control and Prevention, State Key Laboratory for Communicable Disease Prevention and Control, Chinese Center for Disease Control and Prevention, Beijing 102206, China; Department of Epidemiology, School of Public Health, Shandong University, Jinan 250012, China. Department of Stomatology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266003, P.R. China Department of Biochemistry and Molecular Medicine the George Washington University School of Medicine and Health Sciences Washington District of Columbia USA; GW Cancer Center the George Washington University Washington District of Columbia USA From Upper Airway Research Laboratory, Center for Discovery and Innovation Hackensack Meridian Health Nutley New Jersey USA School of Chemistry and Chemical Engineering, Henan Normal University, 46 Jianshe Road, Muye Zone, Xinxiang 453007, P.R. China Department of Allergy and Clinical Immunology, State Key Laboratory of Respiratory Disease, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, China Department of Rheumatology and Clinical Immunology Peking Union Medical College Hospital Peking Union Medical College and Chinese Academy of Medical Sciences Key Laboratory of Rheumatology and Clinical Immunology Ministry of Education Beijing 100032 China Department of Cardiology The First Affiliated Hospital of China Medical University Shenyang China Integrated Systems Engineering, The Ohio State University, Columbus, OH, USA Department of Radiology, the Affiliated Hospital of Guizhou Medical University, Guiyang 550004, China. School of Chemistry and Chemical Engineering/Jiangxi Provincial Key Laboratory of Functional Molecular Materials Chemistry, Jiangxi University of Science and Technology, Ganzhou 341000, Jiangxi Province, PR China The State Key Laboratory and Institute of Elemento-Organic Chemistry College of Chemistry Nankai University Tianjin 300071 P. R. China; Collaborative Innovation Center of Chemical Science and Engineering (Tianjin) Weijin Road 94#, Nankai District Tianjin 300071 China Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA; Deparment of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, P.R. China State Key Laboratory of Efficient Production of Forest Resources , College of Biological Sciences and Technology (Box 162), , Beijing 100083 , P.R. China; Beijing Forestry University , College of Biological Sciences and Technology (Box 162), , Beijing 100083 , P.R. China Radiology Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences Beijing China Department of Mechanical Engineering; City University of Hong Kong; Hong Kong 999077; China Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Center of Excellence in Tissue Engineering Chinese Academy of Medical Sciences, Beijing Key Laboratory (No. BZO381), Beijing 100005, China Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, China; Shandong University of Traditional Chinese Medicine School of Nursing , Jinan, China Department of Physiology and Pathophysiology, Beijing, China Chinese Academy of Sciences Key Laboratory of Receptor Research, National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China; and Leukemia Department, Hematology Center, Beijing Key Laboratory of Pediatric Hematology Oncology; National Key Clinical Discipline of Pediatric Hematology, National Key Discipline of Pediatrics (Capital Medical University); Key Laboratory of Major Diseases in Children, Ministry of Education; Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, China National Center for Nanoscience and Technology, No. 11, Beiyitiao, zhongguancun, Beijing, 100190 People’s Republic of China Department of Traditional Chinese Medicine, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China. lj7357@vip.sina.com School of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of Technology, Wuhan 430070, China Yunnan Key Laboratory of Vaccine Research & Development on Severe Infectious Disease, Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming, China The Key Laboratory of Myocardial Ischaemia Harbin Medical University, Ministry of Education Harbin Heilongjiang China; Department of Cardiology The Second Affiliated Hospital of Harbin Medical University Harbin Heilongjiang China College of Mechanical and Electrical Engineering, China Jiliang University, Hangzhou 310018, China Department of Chemistry Tohoku University Aoba-ku 980-8578 Sendai Japan Department of Gynaecology, Cancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, P.R. China Hebei Key Laboratory of New Functional Materials, School of Material Science and Engineering, Hebei University of Technology, No. 5340, Xiping Road, Beichen District, Tianjin 300401, China Key Laboratory of Ecological Security for Water Source Region of Mid-line of South-to-North Diversion Project of Henan Province; Collaborative Innovation Center of Water Security for Water Source Region of Mid-line of South-to-North Diversion Project of Henan Province; Engineering Technology Research Center of Henan Province for Solar Catalysis; College of Chemistry and Pharmaceutical Engineering; Nanyang Normal University Pediatrics Department, Shanxi Provincial People’s Hospital, Taiyuan, Shanxi 030014, China Department of Chemistry, Washington University in St. Louis, St. Louis, Missouri 63130, United States CAS Key Laboratory of Behavioral Science, Institute of Psychology Chinese Academy of Sciences Beijing China; Department of Psychology University of Chinese Academy of Sciences Beijing China Departments of Pediatrics and Communicable Diseases, Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan; Department of Medicine; and Ben May Institute for Cancer Research, University of Chicago, Chicago, Illinois Department of Pharmaceutical Engineering, College of Plant Protection, Shanxi Key Laboratory of Integrated Pest Management in Agriculture, Shanxi Agricultural University, Taiyuan 030031, China State Key Laboratory of Natural Medicines and Department of Pharmaceutics, China Pharmaceutical University, Nanjing, Jiangsu 210009, China Department of Nutrition, The Affiliated Hospital of Qingdao University, Qingdao, China CAS Key Laboratory of Tropical Plant Resources and Sustainable Use, Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences, Kunming 650223, China Department of Pathology and Pathophysiology, Nanjing Medical University, Nanjing, PR China. wlbianjs@163.com Allergy and Immnunology Institute, School of Medicine, Shenzhen University, Shenzhen 518060, China. College of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, Shanghai 201620, People's Republic of China Center for Health Services Research University of Kentucky College of Medicine Lexington Kentucky Scientific Research Center, China-Japan Union Hospital of Jilin University, Changchun 130033, China 3Department of Oncology, Pharmacology Core, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan. From the Hypertension Center of Fuwai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (L.J., W.W., S.L., X.C., B.G., J.C.); Department of Biomedical Informatics, Physiology, and Pathophysiology, Center for Noncoding RNA Medicine, Peking University Health Science Center, Beijing, China (X.L., J.Y., Q.C., B.G.); Department of Cardiology, Medical Research Center,... Department of Biosciences, Division of Genetics, University of Helsinki, FIN-00014 Helsinki, Finland Chinese Evidence‐Based Medicine Center, West China Hospital Sichuan University Chengdu Sichuan P.R. China School of Traditional Chinese Medicine, Capital Medical University, Beijing 100069, China. The Ninth Peoples Hospital of Chongqing Chongqing China Key Laboratory for Subtropical Wetland Ecosystem Research of MOE, College of the Environment and Ecology Xiamen University Xiamen Fujian 361102 P.R. China Department of Orthodontics, Peking University School and Hospital of Stomatology, Beijing, China.; National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology, Beijing, China. General Surgery Department, The First Hospital of Lanzhou University, The First Clinical Medical College, Lanzhou University, Lanzhou 730000, Gansu Province, China Division of Neurosurgery, City of Hope National Medical Center, Duarte, CA, USA Department of Radiology Affiliated Hospital of Guizhou Medical University Guiyang China Xingaoyi Medical Equipment Company, Yuyao, China Division of Endocrinology and Metabolism, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia 23298 Beijing Engineering Research Center for Experimental Animal Models of Human Diseases Institute of Laboratory Animal Science, Peking Union Medical College, Chinese Academy of Medical Sciences Beijing China School of Food Science and Technology Jiangnan Univ Wuxi 214122 China Department of Nutrition, China−Korea Joint R&D Center on Plant-Derived Functional Polysaccharide, Key Laboratory of Efficient Utilization of Non-Grain Feed Resources, Ministry of Agriculture and Rural Affairs, Shandong Agricultural University, 61 Daizong Street, Taian 271018, China State Key Laboratory of Chemo/Biosensing and Chemometrics; College of Chemistry and Chemical Engineering; College of Biology; Key Laboratory for Bio-Nanotechnology and Molecular Engineering of Hunan Province; Hunan University School of Pharmacy, Anhui University of Chinese Medicine, Hefei, China Department of Gynecologic Oncology Sun Yat‐Sen Memorial Hospital Sun Yat‐Sen University Guangzhou 510120 China; Team‐Based Learning Group of Clinical Study Sun Yat‐Sen University Guangzhou 510000 China Key Laboratory for Polymeric Composite and Functional Materials of Ministry of Education Key Laboratory of High Performance Polymer-based Composites of Guangdong Province School of Chemistry Sun Yat-Sen University Guangzhou 510275 China Key Laboratory of Resource Biology and Biotechnology in Western China (Northwest University), Ministry of Education, School of Life Sciences, Northwest University, Xi’an, Shaanxi 710069, China Department of CyberKnife Center, Huashan Hospital, Fudan University , No. 525, Hongfeng Road, Pudong District , Shanghai 200040 , China Chinese Academy of Medical Sciences, Beijing, China. Department of Acu-moxibustion, Union Hospital, Tongji Medical College, Huazhong University of Scie-nce and Technology, Wuhan 430061. State Key Laboratory of Integrated Management of Insect Pests and Rodents Institute of Zoology Chinese Academy of Sciences Beijing China Department of Neonatology Shanghai Children's Medical Center Shanghai Jiaotong University School of Medicine Shanghai China Intensive Care Unit, Children's Hospital, Chongqing Medical University, Chongqing, China. Department of Oncology, Cancer Center of People's Liberation Army, General Hospital of Shenyang, Military Region, Shenyang, P.R. China Department of Acupuncture-Moxibustion, Yueyang Hospital of Integrated Chinese and Western Medicine, Shanghai University of TCM, Shanghai 200437. 1971921250@qq.com. Department of Pharmacy The 940th Hospital of Joint Logistic Support Force, PLA Lanzhou China; Key Laboratory of the Prevention and Treatment for Injure in Plateau of PLA Lanzhou China Department of Otolaryngology, Affiliated Hangzhou First People's Hospital Zhejiang University School of Medicine Hangzhou Zhejiang Province China Department of Hematology The First Affiliated Hospital of Guangxi Medical University Nanning China Department of Industrial Engineering, Arizona State University, Tempe, AZ, USA Collaborative Innovation Center for Optoelectronic Semiconductors and Efficient Devices, Department of Physics/Pen-Tung Sah Institute of Micro-Nano Science and Technology, Xiamen University, Xiamen, Fujian 361005, China; State Key Laboratory for Manufacturing Systems Engineering, Xi’an Jiaotong University, Xi’an, Shanxi 710049, China; Department of Mechanical Engineering, University of California, Berkeley, California 94720, United States Key Laboratory of Resource Biology and Biotechnology in Western China (Northwest University), Ministry of Education Northwest University Xi'an China Department of Neurology Department of Integrated Systems Engineering, Ohio State University, Columbus, OH, USA Department of Chemistry, State University of New York at Binghamton, Binghamton, New York 13902, United States 2Department of Pharmacology and Glycobiology, Marine Drug and Food Institute, Ocean University of China, Qingdao, P.R. China Department of Emergency Medicine, Center for Advanced Resuscitation Medicine, University of Illinois, Chicago, IL, USA Institute of Biomedicine and Biotechnology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, Guangdong, China; School of Pharmacy, China Medical University, Shenyang 110122, Liaoning, China College of Chemistry and Chemical Engineering Xinyang Normal University Xinyang P. R. China School of Traditional medicine, Beijing University of Chinese Medicine, China Botanical Review Team, Office of New Drug Product, Office of Pharmaceutical Quality, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD, USA School of Nursing Jilin University Changchun China Department of Pathology and Electron Microscopy Center, Faculty of Basic Medical Science, Harbin Medical University, Harbin, China Institute of Mental Health, West China Hospital, Sichuan University, Chengdu, China Department of Genetics and Biochemistry, Clemson University, Room 049 Life Sciences Facility 190 Collings Street, Clemson, South Carolina 29634, United States Department of Parasitology, School of Basic Medical Science, Central South University, Changsha 410013. lijing0807@csu.edu.cn. School of Materials Science and Engineering; South China University of Technology; Guangzhou 510640; PR China; National Engineering Research Center for Tissue Restoration and Reconstruction Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100025, China. Center for Infectious Disease Research, Department of Basic Medical Science, School of Medicine, Tsinghua University, Beijing, China School of Pharmacy Hebei University of Chinese Medicine Shijiazhuang China Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China. Department of Pharmaceutical Engineering, Institute of Chemical Engineering, Tianjin University, Tan 300072, China. Key Laboratory of Bioresources and Ecoenvironment (Ministry of Education), College of Life Sciences, Sichuan University, Chengdu, P.R. China Department of Ophthalmology, the Fourth Affiliated Hospital of China Medical University, Eye Hospital of China Medical University, Key Lens Research Laboratory of Liaoning Province, Shenyang 110005, Liaoning Province, China. Respiratory Department, Tianjin Medical University General Hospital, Tianjin 300052, P.R. China Beijing Key Laboratory of Photoelectronic/Electrophotonic Conversion Materials, Key Laboratory of Cluster Science, Ministry of Education, School of Chemistry, Beijing Institute of Technology, Beijng 100081, P. R. China College of Science; Jinling Institute of Technology; Nanjing 211169; China Beijing Engineering Research Center of Protein and Antibody, Sinocelltech Ltd. Beijing China Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, Hunan, PR China; Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, Hunan, PR China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, PR China Department of Pulmonary and Critical Care Medicine Huashan Hospital, Fudan University Shanghai China 6Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas. Institute of Flexible Electronics (IFE) Northwestern Polytechnical University (NPU) Xi'an 710072 P. R. China College of Biological and Environmental Engineering, Hefei University, Hefei, Anhui 230601, People’s Republic of China 3Department of Oncology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China. Beijing Engineering Research Center for Experimental Animal Models of Human Diseases Institute of Laboratory Animal Science Peking Union Medicine College Chinese Academy of Medical Sciences Beijing China State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, ‡College of Life Science, and §School of Stomatology, Jilin University, Changchun, PR China College of Food Science and Technology, Huazhong Agricultural University, Wuhan, Hubei 430070, People’s Republic of China Department of STD Epidemiology, Chinese Academy of Medical Sciences and Peking Union Medical College Institute of Dermatology/National Center for STD Control, Nanjing, China Department of Otorhinolaryngology, Shandong Provincial Hospital, Shandong University, Jinan 250021, China. Maize Research Institute Sichuan Agricultural University Chengdu 611130 Sichuan China; Key Laboratory of Biology and Genetic Improvement of Maize in Southwest Region Ministry of Agriculture Chengdu 611130 Sichuan China Department of Respiratory Diseases, Guangzhou Institute of Respiratory Disease, Guangzhou, Guangdong 510120, China. Institute of Qinghai‐Tibetan Plateau Southwest Minzu University Chengdu Sichuan Province China Mental Health Center and Psychiatric Laboratory, West China Hospital, Sichuan University, Cheng Du, Si Chuan, People’s Republic of China Departments of Pediatrics and Medicine, University of Chicago, Chicago, Illinois United Imaging Healthcare Shanghai China School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang 212013, P. R. China Department of Anesthesiology; Pharmacology and Physiology; New Jersey Medical School; Rutgers, The State University of New Jersey; Newark New Jersey Quality Control Department, Sinovac Life Sciences Co. Ltd., Beijing, China Department of Thoracic Surgery, The Second Hospital of Hebei Medical University, Shijiazhuang, China Department of Chemistry, Macromolecules and Interfaces Institute, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061; and Department of Infectious Diseases, Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China Department of Burn and Plastic Surgery, Second Affiliated Hospital, Air Force Medical University, Xi’an 710038, China Hoffmann Institute of Advanced Materials Shenzhen Polytechnic 7098 Liuxian Boulevard Shenzhen Guangdong 518055 P. R. China; Department of Chemistry and Chemical Biology Rutgers University 123 Bevier Road Piscataway NJ 08854 USA Guangdong-Hong Kong-Macau Joint Laboratory for Photonic-Thermal-Electrical Energy Materials and Devices Institute of Applied Physics and Materials Engineering University of Macau, Avenida da Universidade Taipa, Macau SAR 999078 P. R. China Department of Respiratory and Critical Care Medicine, the Second Xiangya Hospital, Central South University, Changsha, Hunan, China; Research Unit of Respiratory Disease, Central South University, Changsha, Hunan, China; Diagnosis and Treatment Center of Respiratory Disease, Central South University, Changsha, Hunan, China; Clinical Medical Research Center for Respiratory and Critical Care Medicine in Hunan Province, China From the Multidisciplinary Cardiovascular Research Centre (P.S., A.S., J.L., L.A.W., D.O., K.E.P., M.T.K., J.F.X.A., D.J.B.), Faculty of Biological Sciences (P.S., A.S., J.L., L.A.W., J.D.L., D.J.B.), and Faculty of Medicine & Health (K.E.P., M.T.K., J.F.X.A., D.J.B.), University of Leeds, Leeds, UK; and Department of Cardiac Surgery (D.O.), Leeds General Infirmary, Leeds, UK. Department of Cardiovascular Surgery, the First Affiliated Hospital of Xi’an Jiaotong University, Yanta West Road No. 277, Xi’an 710061, China Department of Prevention and Health Care, Affiliated Hospital of Logistics College of Chinese People's Armed Police Forces, Tianjin 300162, China. Department of Infectious Diseases Huashan Hospital Fudan University Shanghai China Xi’an University of Science and Technology Institute of Geography, Fujian Normal University, Fuzhou 350007, China. School of Geographical Sciences, Fujian Normal University, Fuzhou 350007, China. Key Laboratory for Humid Subtropical Eco-geographical Processes of the Ministry of Education, Fujian Normal University, Fuzhou 350007, China. Wetland Ecosystem Research Station of Minjiang Estuary, State Forestry and Grassland Administration, Fuzhou 350007, China. State Key Laboratory of New Ceramics and Fine Processing and Center for Nano and Micro Mechanics School of Materials Science and Engineering Tsinghua University Beijing 100084 China Department of Surgical Nursing, School of Nursing, Wannan Medical College, 22 Wenchang West Road, Higher Education Park, Wuhu City, Anhui Province, China Department of Statistics University of Connecticut Storrs Connecticut USA Bone and Soft Tissue Tumors Research Center of Yunnan Province, Department of Orthopaedics, the Third Affiliated Hospital of Kunming Medical University (Tumor Hospital of Yunnan Province), Kunming, Yunnan, China; State Key Laboratory of Protein and Plant Gene Research, College of Life Sciences, Peking University, Beijing, China Joint National Laboratory for Antibody Drug Engineering, The First Affiliated Hospital of Henan University, Department of Cell Biology and Genetics, School of Basic Medical Science, Henan University, Kaifeng, China State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Wuhan 430070, People’s Republic of China Department of Breast Surgery; Department of General Surgery; Breast Cancer Institue Authors' Affiliation: The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland Key Laboratory of Biomass Chemical Engineering of Ministry of Education, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, China Department of Cardiology, General Hospital of Northern Theater Command , No. 83 Wenhua Road, Shenhe District, Shenyang 110016, Liaoning , China Department of Endocrinology and Metabolism, The First Hospital of China Medical University, Shenyang, China and Key Laboratory of Endocrine Diseases, Liaoning Province, Shenyang, China Department of Clinical Laboratory the Affiliated Hospital of Medical College Qingdao University Qingdao China Departments of Biochemistry and Medicine, University of Toronto, Toronto, Ontario, Canada, M5S 1A8 Xingaoyi Medical Equipment Co., Ltd. Yuyao, Zhejiang China College of Life Sciences Hebei University Baoding China State Key Lab of Reproductive Medicine Nanjing Medical University Nanjing China MOE Key Laboratory of Low‐Grade Energy Utilization Technologies and Systems School of Energy and Power Engineering Chongqing University 174 Shazhengjie Shapingba Chongqing 400044 China Department of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China Key Laboratory of Marine Drugs; Chinese Ministry of Education; School of Medicine and Pharmacy; Ocean University of China; Qingdao 266003 University of Science and Technology of China National Synchrotron Radiation Lab and College of Nuclear Science and Technology, CAS Key Laboratory of Soft Matter Chemistry, , Hefei, China Department of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, the First Affiliated Hospital of China Medical University , Shenyang 110001, Liaoning Province , China Departrnent of Sports & Health, Nanjing Sport Institute, Nanjing, China. lijing197512@163.com Cancer Center, Renmin Hospital of Wuhan University, Wuhan, Hubei, China Key Laboratory of Ecosystem Network Observation and Modeling; Institute of Geographic Sciences and Natural Resources Research; Chinese Academy of Sciences; Beijing 100101, China National Clinical Research Center of Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease and Division of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of China Department of Information, The First People’s Hospital of Yunnan, Kunming 650021, China State Key Laboratory of Food Nutrition and Safety Tianjin University of Science & Technology Tianjin China; College of Food Science and Engineering Tianjin University of Science & Technology Tianjin China; Key Laboratory of Marine Resource Chemistry and Food Technology (Tianjin University of Science & Technology) Ministry of Education Tianjin China College of Resources and Environment, Southwest Agricultural University, Chongqing 400716, China. lijing@swau.cq.cn General Surgery Department, the First Affiliated Hospital of Anhui Medical University, Hefei, China School of Chemical Engineering, Sichuan University, Chengdu 610065, Sichuan, China Department of Bioinformatics and Biostatistics, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China Upper Airway Research Laboratory, Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey Department of Geriatrics, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China Faculty of Materials Science and Chemistry China University of Geosciences 388 Lumo Road Wuhan 430074 P. R. China Department of Virology, State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, PR China Neurosurgery, The Central Hospital of Wuhan, Wuhan 430014, Hubei, China Center for Drug Delivery and Nanomedicine, Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha 68198, Nebraska, United States Pharmanex Inc., 2000 Sierra Point Parkway, Brisbane, California 94005 Department of Blood Transfusion, The 923 Hospital of the Joint Logistics Support Force of the People's Liberation Army, Nanning, China. for the OPTIMAL Study Group Department of Cardiothoracic Surgery, University Medical Center, Regensburg, Bavaria, Germany Department of Biochemistry and Molecular Genetics University of Illinois Chicago Chicago Illinois USA Department of Chemical and Pharmaceutical Engineering, College of Chemical Engineering, Huaqiao University, Xiamen, PR China Department of Population Health Sciences Weill Cornell Medicine New York NY USA Department of Pathology, Ningxia Medical University Affiliated People's Hospital of Autonomous Region of Ningxia, Yinchuan, Ningxia, 750004, China Department of Biology, Indiana University, Bloomington, IN 47405 The Department of Cardiology General Hospital of Northern Theater Command Shenyang China Key Laboratory of Plant Germplasm Enhancement and Specialty Agriculture, Wuhan Botanical Garden Chinese Academy of Sciences Wuhan Hubei China; Department of Physiology and Functional Genomics University of Florida College of Medicine Gainesville FL USA School of Ecology and Environment, Collaborative Innovation Center of Recovery and Reconstruction of Degraded Ecosystem in Wanjiang Basin Co‐founded by Anhui Province and Ministry of Education Anhui Normal University Wuhu Anhui China Stem Cell Laboratory, Department of Biology, College of Life Sciences, Shanghai Normal University, Shanghai 200234, P.R. China School of Physical Electronics; University of Electronic Science and Technology of China; Chengdu; P. R. China Department of Physics/Pen-Tung Sah Institute of Micro-Nano Science and Technology, ‡School of Energy Research, State Key Lab of Physical Chemistry of Solid Surfaces, College of Chemistry and Chemical Engineering, and §College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, Fujian 361005, China Department of Bioinformatics and Biostatistics School of Life Sciences and Biotechnology Shanghai Jiao Tong University Shanghai China Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA Treatment and Research Center for Infectious Diseases,The Fifth Medical Center of PLA General Hospital,Beijing,China College of Environmental Science and Engineering, Nankai University, Tianjin 300350, China College of Veterinary Medicine, Gansu Agricultural University, Lanzhou, China; China Agricultural Vet. Bio. Science and Technology Co., Ltd., Lanzhou, China Department of Biochemistry and Molecular Medicine The George Washington University School of Medicine and Health Sciences Washington District of Columbia USA; GW Cancer Center The George Washington University Washington District of Columbia USA Department of Public Health and General Medicine, School of Integrated Traditional and Western Medicine, Anhui University of Chinese Medicine, Hefei, China. State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang, Jiangxi, China; Key Laboratory of Tropical Forest Ecology, Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences, Menglun, China; University of Chinese Academy of Sciences, Beijing, China Laboratory of Molecular Target Therapy of Cancer Institute of Basic Medical Sciences Hubei University of Medicine Shiyan Hubei China; Guangdong‐Hongkong‐Macau Institute of CNS Regeneration Jinan University Guangzhou Guangdong China Department of Immunology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China; Department of Biotherapy, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China; National Clinical Research Center for Cancer, Tianjin, China; Key Laboratory of Cancer Prevention and Therapy, Tianjin, China; Tianjin’s Clinical Research Center for Cancer, Tianjin, China The State Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, P. R. China; Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Weijin Road 94#, Nankai District, Tianjin 300071, P. R. China Department of Dermatology, Henan Province Hospital of Traditional Chinese Medicine, The Second Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, People’s Republic of China Department of Geriatrics, the Second Affiliated Hospital, Harbin Medical University, Harbin, PR China Department of Radiology, The First Hospital of Jilin University, Changchun, China Department of Biology, College of Life and Environment Science, Shanghai Normal University, Shanghai, 200234, People's Republic of China Clinical Laboratory Department, The Third Affiliated Hospital of Zhengzhou University, No. 7 Front Kangfu Street, Er’qi Distric, Zhengzhou 450052, China Department of Histology and Embryology, School of Medicine, Nankai University, Tianjin, China Farber Institute for Neurosciences, Thomas Jefferson University, Philadelphia, PA, USA Lab of Stem Cell and Tissue Engineering, Department of Histology and Embryology, Chongqing Medical University, Chongqing, PR China Antibiotics Research and Re-evaluation Key Laboratory of Sichuan Province, School of Pharmacy, Chengdu University, Chengdu, Sichuan, China School of Instrument and Electronics, North University of China, Taiyuan 030051, China; The Academy for Advanced Interdisciplinary Research, North University of China, Taiyuan 030051, China; The Center for Microsystem Integration, North University of China, Taiyuan 030051, China Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, People’s Republic of China, Department of Organic Chemistry, University of Debrecen, POB 20, H-4010 Debrecen, Hungary, and College of Marine Life Sciences, Ocean University of China, Qingdao 266003, People’s Republic of China Department of Environmental and Occupational Health, West China School of Public Health, Sichuan University Chengdu, Sichuan, China. School of Medicine and Life Sciences, University of Jinan-Shandong Academy of Medical Sciences, Jinan, China; State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Shandong Eye Institute, Shandong First Medical University & Shandong Academy of Medical Sciences, Qingdao, China State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Key Laboratory for Bio-Nanotechnology and Molecular Engineering of Hunan Province, Hunan University, Changsha, China †Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, 100730, China;; ‡Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, 100730, China; Center for Infectious Disease Research, School of Medicine Tsinghua University Beijing China Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming, People’s Republic of China Fujian Medical University Affiliated Clinical Medical Institute Fujian Provincial Hospital Nursing School of Fujian Medical University Fuzhou City China Department of Acupuncture, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology (HUST), Wuhan, China Department of Pharmacy, ZhongShan Hospital, FuDan University Key Laboratory of Photochemical Conversion and Optoelectronic Materials Technical Institute of Physics and Chemistry Chinese Academy of Sciences 29 Zhongguancun east road Beijing 100190 China Department of Respiratory, Guangdong General Hospital and Guangdong Academy of Medical Science, Guangzhou, Guangdong 510080, China. Laboratory of Immunobiology, Dana-Farber Cancer Institute, and Department of Medicine, Harvard Medical School, Boston, MA 02115, USA. Nanjing XiaoZhuang University Department of Gastroenterology; Peking University People's Hospital; Beijing China Collaborative Innovation Center of Recovery and Reconstruction of Degraded Ecosystem in Wanjiang Basin Co-founded by Anhui Province and Ministry of Education, School of Ecology and Environment, Anhui Normal University, Wuhu 241000, Anhui, P. R. China State Key Laboratory of Multiphase Complex Systems, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China Key Laboratory of Chemical Biology (MOE) Department of Medicinal Chemistry, School of Pharmacy, Shandong University Jinan China Laborotary of Proteomics, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China, Tianjin Key Laboratory for Biomarkers of Occupational and Environmental Hazard, Medical College of CAPF, Tianjin 300162, China, National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China, and Graduate University of Chinese Academy of Sciences, Beijing 100049, China School of Biology and Biological Engineering South China University of Technology Guangzhou P. R. China State Key Laboratory of Food Science and Technique, Nanchang University, Nanchang 330047, China. doudoulj1@sina.com Department of Anesthesiology, The Second Affiliated Hospital of Xuzhou Medical University, Xuzhou, P.R. China. State Key Laboratory of Natural Medicines, School of Life Science and Technology, China Pharmaceutical University, No. 24 Tongjia Lane, Nanjing, China. Center for Brain Circuit Therapeutics, Department of Neurology, Psychiatry, and Radiology, Brigham and Women’s Hospital, Harvard Medical School , Boston, MA 02115 , USA Jing Li is an assistant professor in the Department of Population Health Sciences at Weill Cornell Medical College. Department of Oncology, Yangzhou NO.1 People's Hospital, The Second Clinical School of Yangzhou University, Yangzhou, Jiangsu Province, China; Research Center of Cancer Prevention and Treatment, Medical College of Yangzhou University, Yangzhou, Jiangsu Province, China Department of Cardiology, Henan Province Key Laboratory of Cardiac Injury and Repair The First Affiliated Hospital of Zhengzhou University Zhengzhou P. R. China State Key Laboratory of Food Nutrition and Safety; Tianjin University of Science and Technology; Tianjin 300457; China College of Bioinformatics Science and Technology at Harbin Medical University, Wenzhou 325027, P. R. China Friedrich-Alexander-Universität Erlangen-Nürnberg; Department of Chemistry and Pharmacy and Interdisciplinary Center for Molecular Materials (ICMM); 91058 Erlangen, Germany Department of Orthodontics, Peking University School and Hospital of Stomatology & National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing, China. Institute of Fluid Physics 1 , CAEP, Mianyang, Sichuan 621900, People's Republic of China Shenzhen Key Laboratory of Steroid Drug Discovery and Development, School of Medicine The Chinese University of Hong Kong Shenzhen Guangdong China; School of Life Sciences University of Science and Technology of China Hefei Anhui China The Third Affiliated Hospital, Nanjing University of CM, Nanjing 210001, Jiangsu Province, China. li780104@163.com Institute of Microelectronics of the Chinese Academy of Sciences, Beijing 100029, China; Key Laboratory of Science and Technology on Silicon Devices, Chinese Academy of Sciences, Beijing 100029, China Surface Engineering Institute, University of Science and Technology Liaoning, Liaoning 114051, China Key Laboratory of Photochemical Conversion and Optoelectronic Materials; Technical Institute of Physics and Chemistry; Chinese Academy of Sciences; Beijing; China Department of Infectious Diseases and HepatologyThe Second Hospital of Shandong University, Jinan, China Shaanxi Key Laboratory of Brain Disorders, Institute of Basic and Translational Medicine, Xi’an Medical University , Xi’an , China Faculty of Materials Metallurgy and Chemistry, Jiangxi University of Science and Technology, Ganzhou, Jiangxi 341000, China; School of Metallurgical Engineering, Jiangxi University of Science and Technology, Ganzhou, Jiangxi 341000, China State Key Laboratory of Pathogens and Bio-Security, Academy of Military Medical Sciences, Beijing, China Shenyang National Laboratory for Materials Science (SYNL); Institute of Metal Research (IMR); Chinese Academy of Sciences (CAS); Shenyang 110016; China Center for Translational Medicine First Affiliated Hospital Xi'an Jiaotong University College of Medicine Xi'an China Division of Cardiology, and School of Acupuncture-moxibustion and Tuina, Beijing University of CM, Beijing 100029. lijingbucm@163.com Beijing Friendship Hospital, Capital Medical University, Beijing, PR China Department of Pharmaceutics, School of Pharmaceutical Science, Zhengzhou University National Clinical Research Center of Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing People's Republic of China Department of Rehabilitation Medicine, TEDA International Cardiovascular Hospital, Cardiovascular Clinical College of Tianjin Medical University, Tianjin, China Henan Provincial Key Laboratory of Surface & Interface Science; Zhengzhou University of Light Industry; Zhengzhou; China Department of Pediatric Intensive Care Unit, Children's Hospital of Chongqing Medical University; Ministry of Education Key Laboratory of Child Development and Disorders; National Clinical Research Center for Child Health and Disorders; China International Science and Technology Cooperation base of Child Development and Critical Disorders; Children's Hospital of Chongqing Medical University; Chongqing Key Laboratory of Pediatrics, Chongqing, China. Forest Products Laboratory and Center for Bioenergy and Bioproducts, Auburn University, 520 Devall Drive, Auburn, Alabama 36849, United States Schoolof Marine Sciences, SunYat-Sen University, Guangzhou, P.R. China; South China Sea Bio-Resource Exploitation and Utilization Collaborative Innovation Center, Guangzhou, P.R. China Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, Michigan; and Ben May Institute for Cancer Research, University of Chicago, Chicago, Illinois School of Medicine and Life Sciences; University of Jinan-Shandong Academy of Medical Sciences; Jinan 250200; China; Institute of Materia Medica Key Lab of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing 210038, China. lijing7609@yahoo.com.cn School of Pharmaceutical Sciences, Sun Yat‑Sen University, Guangzhou, Guangdong 510006, P.R. China Tianjin Key Laboratory of Molecular Optoelectronic, Department of Chemistry, School of Science, Tianjin University, Tianjin, 300072, P. R. China Department of Clinical Laboratory, Shandong Provincial Hospital Affiliated to Shandong University, Shandong, China Department of Obstetrics and Gynecology, Qilu Hospital of Shandong University , Jinan, China State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201620, People’s Republic of China School of Materials Science and Engineering, North University of China, Taiyuan 030051, China School of Economics and Management, Beijing Jiaotong University, Beijing 100044, China. Department of Urology, Second Military Medical University, Shanghai, People's Republic of China; Center for Translational Medicine, Second Military Medical University, Shanghai, People's Republic of China Luoyang Key Laboratory of Live Carrier Biomaterial and Animal Disease Prevention and Control, Luoyang 471023, China; Laboratory of Functional Microbiology and Animal Health, Henan University of Science and Technology, Luoyang 471003, China; College of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471003, China Key Laboratory for Analytical Science of Food Safety and Biology (Ministry of Education), Key Laboratory of Analysis and Detection Technology for Food Safety (Fujian Province), Department of Chemistry, Fuzhou University, Fuzhou 350116, P. R. China Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing 100071, PR China; State Key Laboratory of Pathogens and Biosecurity, Academy of Military Medical Sciences, Beijing 100071, PR China Department of Environmental Science and Engineering, Hangzhou Dianzi University, Hangzhou 310018, China. joyousjj@hdu.edu.cn Department of Clinical Laboratory Medicine, The First Affiliated Hospital of Nanchang University, Nanchang 330006, China Sports Health Technology College, Jilin Sports University, Changchun, Jilin 130022, P.R. China Department of Acupuncture-moxibustion, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China. 461688459@qq.com. State Key Lab of Food Science and Technology Nanchang University Nanchang Jiangxi 330047 PR China Department of Pharmacology, and; Department of Anesthesiology, University of Illinois College of Medicine, Chicago, IL; Key Laboratory of Green Chemistry & Technology of Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, P. R. China Key Laboratory of Cancer Research Center Nantong, Nantong Tumor Hospital, Nantong University, Nantong, China; Karmanos Cancer Institute, Wayne State University, Detroit, MI 48202, USA Department of Biochemistry, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216-4505, USA. Department of Pharmacology, Nanomedicine Engineering Laboratory of Jilin Province, College of Basic Medical Sciences, Jilin University, Changchun 130021, China School of Life Sciences, Southwest Forestry University, Kunming, China Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, PR China E-mail: lijingfmmu@fmmu.edu.cn. Key Laboratory for Animal Biotechnology of Jiangxi Province and the Ministry of Agriculture of China, Jiangxi Agricultural University, Nanchang 330045, People's Republic of China i-Lab, Suzhou Institute of Nano-Tech and Nano-Bionics (SINANO), Chinese Academy of Sciences, Suzhou 215123, China Laboratory of Nanoscale Biochemical Analysis, Institute of Functional Nano & Soft Materials (FUNSOM), Soochow University, Suzhou, 215123, China Cancer Research Center Nantong, Nantong Tumor Hospital & Affiliated Tumor Hospital of Nantong University, Nantong, China Department of Surgical Oncology The First Affiliated Hospital of Bengbu Medical College Bengbu China State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao SAR, China Department of Hematopoietic Stem Cell Transplantation, Affiliated Hospital, Academy of Military Medical Sciences, Beijing 100071, China. Departments of CyberKnife Huashan Hospital Fudan University Shanghai China Shuimu BioSciences Ltd., Beijing 102206, China Department of Histology and Embryology Chongqing Medical University Chongqing P. R. China; Laboratory of Stem Cells and Tissue Engineering Chongqing Medical University Chongqing P. R. China Department of Biomedical Informatics, Vanderbilt University School of Medicine Nashville TN USA The Department of Cardiology, General Hospital of Shenyang Military Region Shenyang China West China Hospital,Sichuan University; Chinese Cochrane Centre; No. 37 Guo Xue Xiang Sichuan University Chengdu Sichuan China 610041 College of Physics and Engineering, Qufu Normal University, Qufu, Shandong 273165, China Department of Pharmacology, Basic Medical School, Wuhan University, Wuhan, China Horticulture Research Institute, Sichuan Academy of Agricultural Sciences & Key Laboratory of Horticultural Crop Biology and Germplasm Creation in Southwestern China of the Ministry of Agriculture and Rural Affairs, Chengdu, China Key Laboratory for Organic Electronics and Information Displays (KLOEID) & Jiangsu Key Laboratory for Biosensors, Institute of Advanced Materials (IAM), National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing University of Posts and Telecommunications, 9 Wenyuan Road, Nanjing 210023, China Department of Pediatrics, China Medical University Affiliated with Shengjing Hospital, Shenyang, 110004 Liaoning, China Department of Pathology Basic Medical Science College Harbin Medical University Harbin China Center for Vision Research, Departments of Ophthalmology and Neuroscience and Physiology, SUNY Upstate Medical University, Syracuse, NY 13210, USA Singapore Eye Research Institute, Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. li.jing@seri.com.sg Center for Molecular Recognition, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, New York, NY 10032 Bioelectronics (ICS‐8) Forschungszentrum Jülich 52425 Jülich Germany Department of Allergy and Clinical Immunology, State Key Laboratory of Respiratory Disease, The First Affiliated Hospital, Guangzhou Medical University Guangzhou 510120, China. Key Laboratory of Optoelectronic Technology and System of Ministry of Education, College of Optoelectronic Engineering, Chongqing University, Chongqing 400044, PR China China Zhongyuan Engineering Corporation, Beijing 100191, China State Key Laboratory of Chemo/Biosensing and Chemometrics; College of Chemistry and Chemical Engineering; Key Laboratory for Bio-Nanotechnology and Molecular Engineering of Hunan Province; Hunan University; Changsha Department of Orthopedics, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China From the Department of Physiology and Pathophysiology (L.W., Y.D., Y.H., J.L., B.L., Y.Z., Y.G., W.K., X.W.), School of Basic Medical Sciences, Peking University; and Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, People’s Republic of China; Department of Cardiology (J.Z.), China-Japan Friendship Hospital, Beijing, People’s Republic of China; Departments of Orthopaedic Surgery and Cell Biology (C.-j.L.), New York University School of Medicine; and Cardiovascular... National Clinical Research Center of Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China; Department of Cardiovascular Surgery, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China. Key Laboratory of Luminescence and Real-Time Analytical Chemistry, Ministry of Education, College of Pharmaceutical Sciences, Southwest University, Chongqing, 400715, People’s Republic of China Department of Evidence‐Based Medicine and Clinical Epidemiology, West China Hospital Sichuan University Chengdu City Sichuan Province PR China; The Chinese Cochrane Center Chengdu City Sichuan Province PR China School of Life and Health Sciences, The Chinese University of Hong Kong, Shenzhen, Longgang District, Shenzhen, Guangdong Province 518172, China CAS Key Laboratory of Tropical Plant Resources and Sustainable Use Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences Mengla Yunnan China Department of Hematology/Oncology Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Key Laboratory of Pediatric Hematology & Oncology of China Ministry of Health, and National Children's Medical Center Shanghai China School of Chemistry and Chemical Engineering Chongqing University Chongqing 400044 P. R. China Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education Wuhan University School of Pharmaceutical Sciences Wuhan Hubei People's Republic of China Pen‐Tung Sah Institute of Micro‐Nano Science and Technology State Key Laboratory for Physical Chemistry of Solid Surfaces Collaborative Innovation Center of Chemistry for Energy Materials National & Local Joint Engineering Research Center for Preparation Technology of Nanomaterials and College of Chemistry and Chemical Engineering Xiamen University Xiamen Fujian 361005 China; Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province (IKKEM) Xiamen 361005 China Shandong Vocational Animal Science and Veterinary College, Weifang 261061, China. School of Pharmacy, Health Science Center, Xi'an Jiaotong University, Xi'an, Shaanxi Province, China State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, The Academy of Military Medical Science, Beijing, China School of Marine Sciences Sun Yat-Sen University Guangzhou 510006 P. R. China College of Medical Engineering & the Key Laboratory for Medical Functional Nanomaterials Jining Medical University Jining 272067 China State Key Laboratory of Electroanalytical Chemistry Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 P. R. China; School of Applied Chemistry and Engineering University of Science and Technology of China Hefei 230026 P. R. China Department of Chemistry & Chemical Biology; Rutgers University; Piscataway; USA College of Pharmaceutical Science Zhejiang University of Technology Hangzhou P.R. China From the *Department of Biomedical Informatics, †School of Computing, Informatics, and Decision Systems Engineering, Arizona State University, Tempe; ‡Department of Radiology, Mayo Clinic, Phoenix, AZ; §Department of Radiology, Mayo Clinic, Rochester, MN; ∥Department of Radiology, Mayo Clinic, Jacksonville, FL; and ¶Department of Research, Mayo Clinic, Scottsdale, AZ. Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States G.V. (Sonny) Montgomery Veterans Affairs Medical Center; Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi Reproductive Medical Center, The Second Hospital Affiliated to Shandong University of Traditional Chinese Medicine Ji'nan China State Key Laboratory of Food Science and Technology, Institute for Advanced Study Nanchang University No. 235 Nanjing East Road Nanchang Jiangxi 330047 China Department of Pulmonary Medicine, Zhongshan Hospital Fudan University Shanghai China Department of Oncology Minimally Invasive, The 307th Hospital of PLA, Affiliated Hospital of Military Medical Sciences, Beijing, China Department of Gastroenterology Zhongshan Hospital Fudan University Shanghai China; Department of Gastroenterology Tongji Hospital Tongji University Shanghai China Department of Pulmonary Medicine, Shanghai Respiratory Research Institute, Zhongshan Hospital, Fudan University, Shanghai 200032, P.R. China Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (C.W., D.G., J.L.); Department of Neuroscience, Baylor College of Medicine, Houston, Texas (J.D.); Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota (P.B.) School of Environment Studies, China University of Geosciences, Wuhan 430074, P. R. China Key Laboratory of Bio-Resources and Eco-Environment (Ministry of Education), College of Life Sciences, Sichuan University, Chengdu, PR China; Faculty of Medicine, Max‐Eder Research Group for Pediatric Sarcoma Biology Institute of Pathology, LMU Munich Munich Germany Department of Cardiology, Shenyang Northern Hospital, Shenyang, Liaoning 110016, China. Department of Medical Engineering, Kunming General Hospital, Kunming 650032, China. li-jingkm@126.com 0000 0001 0708 1323 grid.258151.a The Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology Jiangnan University 214122 Wuxi Jiangsu China School of Life Science and Technology, Tongji University, Shanghai 200092, China. Key Laboratory of Food Nutrition and Safety, Ministry of Education, Tianjin Key Laboratory of Food Nutrition and Safety, College of Chemical Engineering and Materials Science, Tianjin University of Science and Technology, Tianjin 300457, China CAS Key Laboratory of Design and Assembly of Functional Nanostructures, and Fujian Provincial Key Laboratory of Nanomaterials, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian 350002, China Department of Diagnostic Radiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital CAMS&PUMC Beijing China Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China; Key Laboratory of Rheumatology & Clinical Immunology, Ministry of Education, Beijing, China State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Key Laboratory for Bio-Nanotechnology and Molecular Engineering of Hunan Province, Hunan University, Changsha, P. R. China, 410082 Department of Pathology, General Hospital of Beijing Command of PLA, Beijing 100700, China. Cardiovascular Medicine Qilu Hospital of Shandong University Jinan Shandong China Division of Human Gene Therapy, Departments of Medicine, Pathology and Surgery, and the Gene Therapy Center, University of Alabama at Birmingham, 901 19th Street South, BMR2-502, Birmingham, AL 35294, USA Acupuncture-Moxibustion Department, Yueyang Hospital of Integrated Chinese and Western Medicine, Shanghai University of TCM, Shanghai 200437, China. Cancer Research Institute, Southern Medical University, Guangzhou 510515, China Department of Geraeology, Affiliated Hospital of Nantong University, Nantong, P.R. China. School of Marine Sciences, Sun Yat-Sen University , Guangzhou, China College of Life Sciences, Shenzhen University XinHua Hospital, Shanghai Jiao Tong University, Shanghai 200092, China; Department of Epidemiology and Biostatistics, School of Public Health, Tianjin Medical University , Tianjin , China; Tianjin Key Laboratory of Environment, Nutrition and Public Health , Tianjin , China; Tianjin Center for International Collaborative Research on Environment, Nutrition and Public Health , Tianjin , China Department of Pharmacology Nanomedicine Engineering Laboratory of Jilin Province College of Basic Medical Sciences Jilin University Changchun China Department of Molecular Pharmacology, School of Pharmacy, Lanzhou University, Lanzhou, Gansu 730000, P.R. China. Department of Otolaryngology, Eye and ENT Hospital of Fudan University, Shanghai, China.; Department of Otolaryngology, First Hospital of Hangzhou City, Hangzhou, Zhejiang Province, China. School of Pharmaceutical Sciences, Hunan University of Medicine, Huaihua, Hunan, China. College of Food Science and Technology, Huazhong Agricultural University, Wuhan, 430070, China Beijing Key Laboratory of Oil and Gas Pollution Control, China University of Petroleum Beijing, Beijing, P.R. China Department of Thoracic Surgery, The Second Hospital of Hebei Medical University, Shijiazhuang 050000, China Department of Ophthalmology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China CAS and Shandong Province Key Laboratory of Experimental Marine Biology Institute of Oceanology Chinese Academy of Sciences 7 Nanhai Road Qingdao 266071 China; Center for Ocean Mega‐Science Chinese Academy of Sciences 7 Nanhai Road Qingdao 266071 China; Laboratory for Marine Biology and Biotechnology Qingdao National Laboratory for Marine Science and Technology 7 Nanhai Road Qingdao 266071 China Key Laboratory of Molecule Synthesis and Function Discovery (Fujian Province University), College of Chemistry, Fuzhou University, Fuzhou, Fujian 350116, China Department of Scientific Research Center, Gansu Provincial Maternity and Child-Care Hospital, Lanzhou, Gansu Provincial, China; Laboratory Medicine Center, Lanzhou University Second Hospital, Lanzhou, Gansu Provincial, China Laboratory of Virology, Institute of Virology and Biotechnology Zhejiang Academy of Agricultural Sciences Hangzhou China Emergency Intensive Care Unit, The People's Hospital of Langfang City Langfang, China. Key Laboratory of Micro-Nano Materials for Energy Storage and Conversion of Henan Province, College of Advanced Materials and Energy, Institute of Surface Micro and Nano Materials, Xuchang University, Henan, P. R. China School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou, P. R. China 1Department of Endocrinology and Metabolism and The Institute of Endocrinology, NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Hospital of China Medical University, Shenyang, Liaoning, People’s Republic of China Department of Obstetrics and Gynecology Shengjing Hospital of China Medical University Shenyang China State Key Laboratory of Coordination Chemistry, Collaborative Innovation Center of Advanced Microstructures, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China Department of Pathophysiology, Chongqing Medical University, Chongqing, China; Laboratory of Stem Cell and Tissue Engineering, Chongqing Medical University, Chongqing, China From the Multidisciplinary Cardiovascular Research Centre (J.L., P.S., C.J.M., B.K., Z.-Y.M., L.-H.J., K.E.P., D.J.B.) and Institute of Membrane & Systems Biology (J.L., P.S., C.J.M., Z.-y.M., D.J.B.), Faculty of Biological Sciences; and Faculty of Medicine & Health (K.E.P.), University of Leeds; and Yorkshire Heart Centre (C.M.M.), General Infirmary at Leeds, United Kingdom. Graduate School of Human Sciences Osaka University Osaka Japan State Key Laboratory of Biotherapy and Cancer Center; West China Hospital; Sichuan University, and Collaborative Innovation Center of Biotherapy; Chengdu 610041; China Shandong Provincial Key Laboratory/Collaborative Innovation Center of Chemical Energy Storage and Novel Cell Technology and School of Chemistry and Chemical Engineering, Liaocheng University, Liaocheng 252000, People’s Republic of China 1Jiangsu Province Key Laboratory of AnesthesiologyXuzhou Medical University, Xuzhou, China Henan Key Laboratory of Cancer Epigenetics; Cancer Institute, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, China Evidence‐Based Social Sciences Research Center, School of Public Health Lanzhou University Lanzhou China From the Department of Pathology (L.D.A., S.M.M.), Center for Cardiovascular Biology and Regenerative Medicine, and the Department of Biostatistics (A.R.), University of Washington School of Medicine, Seattle; and the Division of Surgical Sciences (R.L.G., J.L.), Wake Forest University School of Medicine, Winston-Salem, NC. Department of Physiology, College of Basic Medicine Chongqing Medical University Chongqing China; Laboratory of Stem Cells and Tissue Engineering, College of Basic Medicine Chongqing Medical University Chongqing China Marine Drugs Research Center, Department of Pharmacy, State Key Laboratory of Oncogenes and Related Genes, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, People’s Republic of China State Key Laboratory of Materials-Oriented Chemical Engineering; College of Chemistry and Chemical Engineering; Nanjing Tech University (former Nanjing University of Technology); Nanjing; P. R. China Department of Chemistry, Natural Products LINCHPIN lab, Texas A&M University, College Station, Texas, USA State Key Laboratory of Crop Stress Biology for Arid Areas/College of Agronomy Northwest A & F University Yangling China Chongqing Key Laboratory of Chemical Process for Clean Energy and Resource Utilization; School of Chemistry and Chemical Engineering; Chongqing University; Chongqing 400044; China Department of Radiation Medicine, Faculty of Preventive Medicine, The Fourth Military Medical University, Xi'an, People's Republic of China. The State Key Laboratory and Institute of Elemento-Organic Chemistry, the College of Chemistry, Nankai University, Tianjin 300071, China; Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Weijin Road 94, Nankai District, Tianjin 300071, China Center for Drug Delivery and Nanomedicine, Department of Pharmaceutical Sciences and ‡Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, Nebraska 68198, United States Department of Neurology, Xiangya Hospital, Central South University , Changsha, China Department of Chemistry Tsinghua University Beijing 100084 China Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China State Key Laboratory of Cancer Biology, Department of Pathology, Xi Jing Hospital, Fourth Military Medical University, Xi'an 710032, China. State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, Guangdong, People’s Republic of China State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Collaborative Innovation Center of Advanced Microstructures, Nanjing University, Nanjing 210023, P. R. China State Key Laboratory of Food Science and Technology University of Nanchang Nanchang Jiangxi 330047 China Department of Hepatobiliary Surgery, Xinqiao Hospital, Third Military Medical University, Chongqing, China. Department of Histology and Embryology, North Sichuan Medical College, Nanchong, Sichuan, China From Upper Airway Research Laboratory, Department of Biomedical Research Hackensack University Medical Center Hackensack New Jersey 07601 Key Laboratory of TCM-information Engineer of State Administration of TCM, Beijing University of Chinese Medicine, Beijing, China; School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, China Department of Pulmonary and Critical Care Medicine, Shenzhen University General Hospital, Shenzhen 518055, China School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China Gansu Provincial Cancer Hospital Department of Pathology, Affiliated Shanxi Tumor Hospital of Shanxi Medical University, Taiyuan, Shanxi 030013, P.R. China From the Departments of Microbiology and Immunology, Changsha, Hunan, China College of Basic Medical Sciences; Jilin University; Changchun 130021; China Department of Radiology, Beijing Friendship Hospital Capital Medical University Beijing China Department of Pathology & Key Laboratories for Xinjiang Endemic & Ethnic Diseases, Shihezi University School of Medicine, Shihezi, Xinjiang, China Department of Analysis Chemistry, Peking University School of Pharmaceutical Sciences, Beijing 100083, China. 3Wake Forest School of Medicine, Winston Salem, North Carolina. Functional Nanomaterials Laboratory Center for Micro/Nanomaterials and Technology and Key Laboratory of Photochemical Conversion and Optoelectronic Materials Technical Institute of Physics and Chemistry Chinese Academy of Sciences Beijing 100190 China Department of Chemistry and Chemical Biology; Rutgers University; Piscataway, USA The Key Laboratory of Chemical Metallurgy Engineering of Liaoning Province and School of Materials and Metallurgy, University of Science and Technology Liaoning, Anshan, Liaoning Province 114051, China Peter Grünberg Institute (PGI-8), Forschungszentrum Jülich, Jülich 52425, Germany Department of Infectious Diseases and Hepatology The Second Hospital of Shandong University Jinan Shandong Province China Institute of Medical Biology, Chinese Academy of Medicine Science and Peking Union Medical College, Yunnan Key Laboratory of Vaccine Research and Development on Severe Infectious Diseases, Kunming, China Department of Biological and Pharmaceutical Engineering College of Biomedical Engineering Taiyuan University of Technology 79 West Yingze Street Taiyuan 030024, Shanxi P. R. China Department of Anesthesiology New Jersey Medical School, University of Medicine and Dentistry of New Jersey Newark NJ USA Department of Forensic Science, Jiangsu Police Institute Nanjing 210031 P. R. China Institute of Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, CA, USA. BGI-Shenzhen, Shenzhen, China; China National GeneBank, BGI-Shenzhen, Shenzhen, China; Guangdong Provincial Key Laboratory of Genome Read and Write, BGI-Shenzhen, Shenzhen, China; BGI Education Center, University of Chinese Academy Sciences, Shenzhen, China MOE Key Laboratory of Protein Sciences, Tsinghua-Peking Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China Shandong Provincial Key Laboratory of Chemical Energy Storage and Novel Cell Technology, College of Chemistry and Chemical Engineering, Liaocheng University, Liaocheng 252059, China; Center for Applied Chemical Research, Frontier Institute of Science and Technology and Shaanxi Key Laboratory of Energy Chemical Process Intensification, School of Chemical Engineering and Technology, Xi’an Jiaotong University, Xi’an 710049, China Institution of Epidemiology and Statistics, School of Public Health, Lanzhou University , 199 Donggang West Road, Lanzhou, Gansu 730000 , China Jinagsu Key Laboratory of Medical Science and Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang, China. Department of Chemistry, Ohio University, Athens, Ohio 45701, Department of Chemistry, Mississippi College, Clinton, Mississippi 39085, Department of Chemistry, Jackson State University, Jackson, Mississippi 39217, and Centre for Molecular Design, Department of Chemistry, University of the Witwatersrand, P.O. Wits, 2050 Johannesburg, South Africa School of Basic Medical Sciences, Fujian Medical University, Fuzhou 350122, China. 1Department of Cell Biology, Harvard Medical School, Boston, Massachusetts. Ministry of Education Key Laboratory of Analytical Science for Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou, Fujian 350116, China Key Laboratory of Ministry of Education for Gastrointestinal Cancer, Department of Bioinformatics, School of Basic Medical Sciences, Fujian Medical University, Fuzhou 350001, China Department of Obstetrics and Gynecology, Shenzhen Longhua District Central Hospital, Guangdong Medical University Affiliated Longhua District Central Hospital, Shenzhen, China Department of Orthopedic Oncology, Xijing Hospital affiliated to the Fourth Military Medical University, Xi'An, China State Key Laboratory of Heavy Oil Processing, Key Laboratory of Bioengineering and Biotechnology in Universities of Shandong, Centre for Bioengineering and Biotechnology, China University of Petroleum (East China), Qingdao, China Xinjiang Plant Protection Station Urumqi China Department of Medicinal and Applied Chemistry Kaohsiung Medical University 100, Shih-Chuan 1st Road, Sanmin District Kaohsiung 807 Taiwan National Clinical Research Center for Cardiovascular Diseases, National Health Commission Key Laboratory of Clinical Research for Cardiovascular Medications, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, National Center for Cardiovascular Diseases, Beijing, China; Fuwai Hospital Chinese Academy of Medical Sciences, Shenzhen, China School of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing 400054, China CAS Key Laboratory of Tropical Plant Resources and Sustainable Use Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences Kunming Yunnan China Department of Ophthalmology Huizhou Central People's Hospital Huizhou People's Republic of China Medical Examination Center, Hebei Medical University Fourth Affiliated Hospital and Hebei Provincial Tumor HospitalShijiazhuang, HebeiP.R. China Tianjin Key Laboratory of Molecular Optoelectronic, Department of Chemistry, School of Science, Tianjin University, Tianjin 300072, People’s Republic of China Division of TB and HIV/AIDS Prevention, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, People’s Republic of China; Shanghai Institutes of Preventive Medicine, Shanghai, People’s Republic of China College of Life Sciences Capital Normal University Beijing China The Department of Psychiatry, State Key Lab of Biotherapy, West China Hospital of Sichuan University, Chengdu, China. Department of Hepatobiliary Surgery of the Affiliated Hospital, Southwest Medical University, Luzhou, Sichuan, China The Scripps Research Institute, d/b/a Calibr, a division of Scripps Research, 11119 North Torrey Pines Road, Suite 100, La Jolla, California 92037, United States Department of Economic Plants and Biotechnology, Yunnan Key Laboratory for Wild Plant Resources Kunming Institute of Botany, Chinese Academy of Sciences Kunming 650201 China Karmanos Cancer Institute Department of Oncology Wayne State University School of Medicine Detroit MI USA Changchun University of Chinese Medicine, Changchun, Jilin 130117, China Department of Mother and Children's Health Care, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, China Technical Institute of Physics and Chemistry Chinese Academy of Sciences Beijing 100190 P. R. China Beijing University of Chinese Medicine; Centre for Evidence-Based Chinese Medicine; Bei San Huan Dong Lu 11, Chaoyang District Beijing China 100029 Beijing Advanced Innovation Center for Soft Matter Science and Engineering, College of Life Science and Technology Beijing University of Chemical Technology Beijing China Faculty of Medicine and Dentistry, Department of Cell Biology, University of Alberta, Edmonton, AB, Canada. Department of Diagnostic Radiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China; Department of Nuclear Medicine (PET‐CT Center) National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China Department of Clinical Laboratory, The Affiliated Hospital of Qingdao University, 19 Jiangsu Road, Qingdao 266003, China; Department of Medical Microbiology, Qingdao University Medical College, 38 Dengzhou Road, Qingdao 266021, China Department of Stomatology, Huadong Hospital, Fudan University, Shanghai 200437, China The Second Department of Cardiology, Affiliated Hospital of Hebei University, Baoding City, 071000, Hebei Province, China Research Center for Marine Drugs, State Key Laboratory of Oncogenes and Related Genes, Department of Pharmacy, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, People’s Republic of China Key Laboratory of Subsurface Hydrology and Ecological Effects in Arid Region Ministry of Education Chang'an University Xi'an China; School of Water and Environment Chang'an University Xi'an China University of Chinese Academy of Sciences Department of Endocrinology and Metabolism, Sichuan University West China Hospital, Chengdu, Sichuan 610041, China Department of Ophthalmology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, China Guangzhou Key Laboratory for Surface Chemistry of Energy Materials New Energy Research Institute School of Environment and Energy South China University of Technology 510006 Guangzhou P. R. China Department of Gynecology, Qingdao Hospital, University of Health and Rehabilitation Sciences (Qingdao Municipal Hospital), Qingdao, Shandong 266000, China State Key Laboratory of Molecular Biology CAS Center for Excellence in Molecular Cell Science Shanghai Institute of Biochemistry and Cell Biology Chinese Academy of Sciences University of Chinese Academy of Sciences Shanghai China; School of Life Science and Technology ShanghaiTech University Shanghai China Department of Orthopedics, Three Gorges Central Hospital of Chongqing, Chongqing 404000, P.R. China College of Life Sciences Nanjing Agricultural University Nanjing Jiangsu 210095 China Department of Chemistry, Key Laboratory of Environmentally Friendly Chemistry and Applications of Ministry of Education, Key Laboratory for Green Organic Synthesis and Application of Hunan Province, Xiangtan University, Xiangtan, Hunan Province 411105, China Department of Biology, College of Life Sciences, Shanghai Normal University, Shanghai, China. School of Automation Engineering, Northeast Electric Power University, Jilin, China State Key Laboratory of Marine Pollution (SKLMP), City University of Hong Kong, Hong Kong SAR, China; Department of Chemistry, City University of Hong Kong, Hong Kong SAR, China; Department of Transportation and Environment, Shenzhen Institute of Information Technology, Shenzhen 518172, China Department of Pathology and Forensic Medicine, College of Basic Medical Sciences Dalian Medical University Dalian China Department of Chemistry, Xixi Campus, Zhejiang University, Hangzhou 310028, China. lijing_1107@163.com Key Laboratory for Advanced Materials and Institute of Fine Chemicals, East China University of Science and Technology, Shanghai 200237, P.R. China Department of Public Health and General Medicine, Anhui University of Chinese Medicine, Hefei, Anhui, China; School of Life and Health Sciences, The Chinese University of Hong Kong, Shenzhen, Longgang District, Shenzhen, Guangdong518172, China; Warshel Institute for Computational Biology, The Chinese University of Hong Kong, Shenzhen, Longgang District, Shenzhen, Guangdong518172, China Key Laboratory of Bio-Resources and Eco-Environment, Ministry of Education, College of Life Science, Sichuan University, 29 Wangjiang Rd, Chengdu 610065, China College of Veterinary Medicine, China Agricultural University, No. 2 Yuanmingyuan West Rd, Haidian District, Beijing 100193, China Department of Bioinformatics, Fujian Medical University, Fuzhou, China School of Energy and Materials, Shanghai Polytechnic University, Shanghai 201209, China; Shanghai Engineering Research Center of Advanced Thermal Functional Materials, Shanghai 201209, China Department of Pharmaceutical Sciences, Wayne State University, Detroit, Michigan 48202, United States Tianjin Key Laboratory for Modern Drug Delivery and High Efficiency School of Pharmaceutical Science and Technology Tianjin University Tianjin People's Republic of China Department of pharmacy, Ningbo University affiliated Yangming Hospital, Yuyao, China Institute of Integrated Traditional Chinese and Western Medicine Center for Exchange and Cooperation of Traditional Chinese Medicine Toward Hongkong, Maco and Taiwan, State Administration of Traditional Chinese Medicine, Beijing 100027. Université Côte d'Azur CNRS INSERM IRCAN Medical School of Nice Nice France Department of Spine Surgery The Second Xiangya Hospital Central South University Changsha, China School of Biology, Georgia Institute of Technology, Atlanta, Georgia 30332-0230 College of Tourism and Geography, Jiujiang University, Jiujiang 332005, China. Department of Allergy and Clinical Immunology State Key Laboratory of Respiratory Disease National Clinical Research Center for Respiratory Disease Guangzhou Institute of Respiratory Health The First Affiliated Hospital of Guangzhou Medical University Guangzhou China 2Eli Lilly and Company, Indianapolis, IN Department of Anesthesiology, Pharmacology and Physiology, New Jersey Medical School Rutgers, The State University of New Jersey Newark NJ USA Department of PICU, Children's Hospital of Chongqing Medical University, Chongqing 400014, China. Key Laboratory of Nonferrous Metals Chemistry and Resources Utilization of Gansu Province and State Key Laboratory of Applied Organic Chemistry; College of Chemistry and Chemical Engineering; Lanzhou University; Lanzhou 730000; P. R. China Department of Pulmonary and Critical Care Medicine, Peking University People’s Hospital, Beijing, China Department of Psychiatry The Chinese University of Hong Kong Hong Kong SAR China CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203, People’s Republic of China National Clinical Research Center of Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing (X.H., X.B., H.Z., X.Y., Y.S., J. Liu, X.W., W.G., X.W., J.Li, X.L., X.Z.). Department of Hepatobiliary The Second Affiliated Hospital of Army Medical University Chongqing China College of Veterinary Medicine, China Agricultural University, Beijing, China MedImmune, San Francisco, CA 94080, USA. Department of Surgery and Departemnt of Physiology & Cell Biology, College of Medicine, Davis Heart and Lung Research Institute, Wexner Medical Center, The Ohio State University, Columbus, OH USA School of Civil Engineering, Purdue University, West Lafayette, Indiana 47907-2051 Department of Pediatrics, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China Department of Surgical Oncology, The First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui, People’s Republic of China Basic Medical College, Xinjiang Medical University, Urumqi, Xinjiang, China Department of Pulmonary Medicine, Peking University People’s Hospital , Beijing, China Department of Respiratory Medicine, Affiliated Hospital of Luzhou Medical College, Luzhou 646000, China. Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University , No. 246 Xuefu Road, Nangang District, Harbin 150086, China Department of Civil Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China Brookhaven National Laboratory Center for Functional Nanomaterials Upton NY 11973 USA From Roche Molecular Solutions, Pleasanton, California (Dr Huang, Mr Smith, Dr Le, Mr Liu, Dr Ordinario, Dr Manohar, Mr Lee, Mr Rajamani, Mr Truong, Dr Jing Li, Ms Choi, Dr Jingchuan Li, Dr Pati, Dr Hanlon Newell, Mr Pate, and Dr Menzl); Institute of Pathology, University Hospital Basel, Basel, Switzerland (Dr Bubendorf); Institute for Pathology, University Hospital, Cologne, Germany (Dr Buettner Section of Emergency Medicine, Department of Medicine, Emergency Resuscitation Center, Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, China College of Chemistry, Sichuan University, Chengdu 610064, China Department of General Surgery, The Third Affiliated Hospital of Chongqing Medical University (Gener Hospital) , Shuanghu Road, Chongqing 401120 , China Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center , Houston, Texas, USA James Graham Brown Cancer Center, University of Louisville, 529 South Jackson Street, Louisville, Kentucky 40202 Department of Vascular Anomalies and Interventional Radiology, Ji’nan Children's Hospital, Jinan Institute of Molecular Physiology, Shenzhen Bay Laboratory Department of Hematology, The First Affiliated Hospital of Guangxi Medical University, Key Laboratory of Hemotology, Education Department of Guangxi Zhuang Autonomous Region, Guangxi Medical University, Nanning, Guangxi 530021, People’s Republic of China Center for Molecular Metabolism, Nanjing University of Science & Technology, Nanjing, China Key Laboratory of Molecule Synthesis and Function Discovery, College of Chemistry, Fuzhou University, Fuzhou 350116, P. R. China Key Laboratory of Energy Materials Chemistry, Ministry of Education; Key Laboratory of Advanced Functional Materials, Autonomous Region; Institute of Applied Chemistry, Xinjiang University, Urumqi, 830046 Xinjiang, People’s Republic of China Key Laboratory of the Ministry of Education for Coastal and Wetland Ecosystems College of the Environment and Ecology Xiamen University Xiamen China Department of Bone and Soft Tissue Oncology, Gansu Provincial Tumor Hospital, Lanzhou 730050, China. Alberta Ingenuity Centre for Carbohydrate Science and Department of Chemistry, Gunning-Lemieux Chemistry Centre, University of Alberta, Edmonton, AB T6G 2G2 Canada State Key Laboratory of Physical Chemistry of Solid Surfaces, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, P. R. China Tianjin Key Laboratory of Environmental Remediation and Pollution Control, College of Environmental Science and Engineering Nankai University Tianjin 300350 China School of Mechanical Engineering, Guangxi University, Nanning, China Xiangya School of Pharmaceutical Sciences, Central South University, Changsha 410013, China School of Public Health, Weifang Medical University, Weifang 261053, Shandong, China;"Health Shandong" Major Social Risk Prediction and Governance Collaborative Innovation Center, Weifang 261053, Shandong, China. School of Journalism and Communication, Shandong Normal University, Jinan, China Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China Glyn O. Phillips Hydrocolloid Research Centre, National “111” Center for Cellular Regulation and Molecular Pharmaceutics, Key Laboratory of Fermentation Engineering of Ministry of Education, Key Laboratory of Industrial Microbiology in Hubei Province, Department of Bioengineering and Food Science, Hubei University of Technology, Wuhan 430068, China Trinity College Dublin Department of Respiratory and Critical Care Medicine, Huashan Hospital Fudan University Shanghai China Academy of Opto-Electric Technology, Special Display and Imaging Technology, Innovation Center of Anhui Province, National Engineering Laboratory of Special Display Technology, Anhui Province Key Laboratory of Measuring Theory and Precision Instrument, School of Instrument Science and Optoelectronics Engineering, Hefei University of Technology, Hefei 230009, China Guangzhou Institute of Respiratory Disease, First Affiliated Hospital of Guangzhou Medical College, Guangzhou 510120, China. jingli1016@21cn.com School of Materials Science and Engineering; Changzhou University; Changzhou; China; College of Material and Textile Engineering School of Marine Sciences, Sun Yat-Sen University, Guangzhou, China Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing, China School of Nursing Weifang Medical University Weifang Shandong Province PR China; School of Public Health Weifang Medical University Weifang Shandong Province PR China State Key Laboratory of Food Science and Technology and Institute for Advanced Study, Nanchang University, Nanchang 330047, Jiangxi Province, China Chinese Academy of Engineering Physics, Institute Fluid Physics , Mianyang 621999, China Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming, China The Second Hospital of Hebei Medical University State Key Laboratory for Swine Genetic Improvement and Production Technology, Jiangxi Agricultural University, Nanchang, China State Key Laboratory of Medicinal Chemical Biology and College of Pharmacy, Nankai University, Tianjin 300071, China College of Life Sciences & Key Laboratory for Bio-resources of Ministry of Education, Sichuan University, Chengdu 610064, China National Research and Development Center for Egg Processing, College of Food Science and Technology Huazhong Agricultural University Wuhan 430070 China Sinovac Biotech Co., Ltd., Beijing 100085, China Department of Pulmonary and Critical Care Medicine, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangdong Provincial Geriatrics Institute , Guangzhou , China Cancer Institute/Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. Department of Quality Management, Jinan Central Hospital Affiliated to Shandong University Jinan 250013, China. From the Department of Biopharmaceutical Sciences, College of Pharmacy (J.L., J.R., Y.L., Y.Z., Q.Z., D.Z.), Harbin Medical University-Daqing, Daqing, Heilongjiang, China; Biopharmaceutical Key Laboratory of Heilongjiang Province (D.Z.), Harbin, China; and Department of Pharmacology, Harbin Medical University-Daqing, Daqing, China (Y.C.). Department of Obstetrics Nanjing Drum Tower Hospital Affiliated Hospital of Medical School, Nanjing University, No.321 Zhongshan Road Nanjing China NHC Key Laboratory of Clinical Research for Cardiovascular Medications, National Clinical Research Center of Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, National Center for Cardiovascular Diseases, People’s Republic of China MOE Key Laboratory of Macromolecular Synthesis and Functionalization (Ministry of Education), Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China The Second Hospital Affiliated to Shandong University of Traditional Chinese Medicine, No. 1 Jingba Road, Jinan 250001, Shandong, China Department of Mechanical and Biomedical Engineering City University of Hong Kong 999077 Hong Kong Division of Gastroenterology and Hepatology, Institution of Digestive Diseases, Tongji Hospital, Tongji University School of Medicine, Shanghai, P. R. China Department of Radiology, Beijing Tongren Hospital, Capital Medical University, Beijing, China State Key Laboratory of Separation Membrane and Membrane Process, School of Materials Science and Engineering & School of Chemistry, Tiangong University, Tianjin 300387, China Department of Neurology Affliated Hospital of Yanbian University Yanji Jilin China Guangdong Provincial Key Laboratory of Functional Soft Condensed Matter, School of Materials and Energy, Guangdong University of Technology, Guangzhou 510006, China College of Horticulture, Fujian Agriculture and Forestry University, Fuzhou 350002, China Department of Dermatology, Peking University First Hospital, Beijing 100034, China. State Key Laboratory of Oral Diseases West China College of Stomatology Sichuan University Chengdu China State Key Lab of Food Science and Technology Univ. of Nanchang Nanchang 330047 Jiangxi China Department of Infectious Diseases Research Laboratory of Clinical Virology Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China.; Department of Pathology, Fujian Provincial Maternity Hospital, Fuzhou, China. Authors' Affiliations: 1Division of Hematology/Oncology, 2Genentech, South San Francisco; 3Helen Diller Comprehensive Cancer Center; and 4Department of Radiology, 5Laboratory Medicine, University of California, San Francisco, San Francisco, California Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany State Key Laboratory of Organic Geochemistry and Guangdong-Hong Kong-Macao Joint Laboratory for Environmental Pollution and Control, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou 510640, China CAS Key Laboratory of Experimental Marine Biology Institute of Oceanology Chinese Academy of Sciences 7 Nanhai Rd. Qingdao 266071 China; Center for Ocean Mega‐Science Chinese Academy of Sciences 7 Nanhai Road Qingdao 266071 China; Laboratory for Marine Biology and Biotechnology Qingdao National Laboratory for Marine Science and Technology 7 Nanhai Rd Qingdao 266071 China Key Laboratory of Human Disease Comparative Medicine NHFPC Institute of Laboratory Animal Science Peking Union Medicine College Chinese Academy of Medical Sciences Beijing China Hainan Key Laboratory of Tropical Oil Crops Biology/Coconut Research Institute Chinese Academy of Tropical Agricultural Sciences Wenchang China Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College National Clinical Research Center for Dermatologic and Immunologic Diseases Beijing China Institute for Translational Medicine The Affiliated Hospital of Qingdao University Medical College Qingdao University Qingdao P. R. China Department of Clinical Research, Sinovac Biotech Co., LTD, Beijing, China School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China; Key Laboratory of Preclinical Study for New Drugs of Gansu Province, Lanzhou University, Lanzhou 730000, China Department of Horticulture, College of Horticulture and Landscape Hunan Agricultural University Changsha China; National Centre for Citrus Improvement Changsha China Department of Mathematics California State University, Northridge Northridge California 91330 USA 1Department of Biochemistry and Molecular Medicine, The George Washington University School of Medicine and Health Sciences, Washington, District of Columbia.; 2GW Cancer Center, The George Washington University, Washington, District of Columbia. Heart Center & Beijing Key Laboratory of Hypertension Beijing Chaoyang Hospital Capital Medical University Beijing China Institute of Animal Nutrition Sichuan Agricultural University Chengdu P. R. China; Key Laboratory for Animal Disease‐Resistant Nutrition of the Ministry of Education of China Sichuan Agricultural University Chengdu P. R. China; Key Laboratory of Animal Disease‐Resistant Nutrition of Sichuan Province Sichuan Agricultural University Chengdu P. R. China Department of Healthcare Policy and Research, Weill Cornell Medical College, New York, New York. Key Laboratory of Industrial Microbiology, Ministry of Education, Tianjin Key Laboratory of Industry Microbiology, National and Local United Engineering, Lab of Metabolic Control Fermentation Technology, College of Biotechnology Tianjin University of Science and Technology Tianjin China Plant Physiology, Institute of Biochemistry and Biology, University of Potsdam, 14476 Potsdam-Golm, Germany (C.E., T.A., S.M., M.H., M.S., G.R.); Australian Research Council Centre of Excellence in Plant Energy Biology, University of Western Australia, Crawley, Western Australia 6009, Australia (J.L., S.M.S.); Molecular Biology, University Malaysia Sarawak, 94300 Kota Samarahan, Sarawak, Malaysia Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada Key Laboratory of Molecular Developmental BiologyInstitute of Genetics and Developmental Biology, Chinese Academy of Sciences Beijing China Institute of Functional Material Chemistry, Faculty of Chemistry, Northeast Normal University, Changchun 130024, Jilin, P. R. China Department of Chemistry and Chemical Biology; NJ 08854; USA Department of Internal Medicine, Qingdao Health Care Center for Women and Children, Qingdao 266011, China. Institute of Micro-Nano Optoelectronics and Terahertz Technology, and School of Mechanical Engineering, Jiangsu University, Zhenjiang 212013, China The National Engineering Research Center for Crop Molecular Breeding, MARA Key Laboratory of Soybean Biology (Beijing) Institute of Crop Sciences, Chinese Academy of Agricultural Sciences 12 Zhongguancun South Street Beijing 100081 China Department of Forensic Medicine, Xiangya School of Medicine, Central South University, Changsha 410078, China. tzc9065@hotmail.com Obstetrics Department, Yidu Central Hospital of Weifang, Qingzhou, Shandong, China. School of Life Science and Technology, China Pharmaceutical University, Nanjing 211198, China; Hunan Key Laboratory for Bioanalysis of Complex Matrix Samples, Changsha 410000, China Division of Reproductive Biology (J.V.Z., H.J., C.-W.L., C.K., A.D., E.B., J.L., A.J.W.H.), Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, California 94305 Department of Neurology, The First Hospital of Jilin University, Changchun, China; Department of Neurological Surgery and Brain and Mind Research Institute, Weill Cornell Medicine of Cornell University, New York Presbyterian Hospital, New York, USA UMR 5174 EDB (Laboratoire Evolution & Diversité Biologique) Université de Toulouse ENFA 118 route de Narbonne F‐31062 Toulouse France; UMR 5174 EDB CNRS Université Paul Sabatier F‐31062 Toulouse France; State Key Laboratory for the Biology of the Plant Diseases and Insect Pests Institute of Plant Protection Chinese Academy of Agricultural Sciences No.2 West Yuanmingyuan Road Beijing 100193 China; School of biological technology Xi'an University of Arts and Science No.168 South Taibai Road Xi'an Shaanxi Province 710065 China Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA Institute of Functional Material Chemistry Key Laboratory of Polyoxometalate Science of Ministry of Education Northeast Normal University, Changchun 130024 Jilin P. R. China Alnylam, Cambridge, MA, USA Department of Science and Education, Shenyang Women and Children Health Care Centre, Shenyang, China Medical School of Chinese People's Liberation Army, Beijing 100853, China; Department of Radiology, Characteristic Medical Center of Chinese People's Armed Police Force, Tianjin 300162, China Department of Orthopedics, Chinese People’s Liberation Army (PLA) General Hospital, Beijing, China (mainland) Liver Cirrhosis Study Group Department of Gastroenterology General Hospital of Shenyang Military Area Shenyang China Institute of Biochemistry and Molecular Biology, Guangdong Medical University, P.R. China CAS Key Laboratory of Design and Assembly of Functional Nanostructures Fujian Provincial Key Laboratory of Nanomaterials Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences Fuzhou Fujian 350002 P. R. China Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, New Jersey 08854-8087, United States Department of Cardiology General Hospital of Northern Theater Command Shenyang China; Department of Cardiology The Graduate School of Harbin Medical University Harbin China State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Key Laboratory for Bio-Nanotechnology and Molecular Engineering of Hunan Province, Hunan University, Changsha 410082, P.R. China Department of Oncology, The First Affiliated Hospital to Hunan University of Chinese Medicine, Changsha 410000, China Department of Intervention Drug Clinical Trial Center, The Third Affiliated Hospital of Qiqihar Medical University, Qiqihar, Heilongjiang, China School of Chemistry and Chemical Engineering; Shandong University; Jinan 250100; China Department of Hematology, Rizhao People's Hospital, Rizhao, Shandong 276826, P.R. China West China School of Public Health, Sichuan University/West China Forth Hospital, Sichuan University, Chengdu, China Department of Pathology, Shanxi Tumor Hospital, Shanxi Medical University, Taiyuan 030013, China. State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300353, China; Department of Chemistry, Georgia State University, Atlanta, Georgia 30303, United States Department of Psychiatry, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. College of Marine Life Science, Ocean University of China, Qingdao, People’s Republic of China. Department of Clinical Laboratories, Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an Jiaotong University, Xi’an, China State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China; School of Information Engineering, Nanchang University, Nanchang, China T.C. Jenkins Department of Biophysics, Johns Hopkins University, Baltimore, MD 21218, U.S.A.; Department of Biology, Johns Hopkins University, Baltimore, MD 21218, U.S.A. Department of Geriatrics, the Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang P.R. China Tianjin Eye Hospital, Tianjin, China.; Tianjin Key Lab of Ophthalmology and Visual Science, Tianjin, China.; Tianjin Eye Institute, Tianjin, China. State Key Laboratory of Advanced Medical Materials and Devices Tianjin Key Laboratory of Biomedical Materials Institute of Biomedical Engineering Chinese Academy of Medical Sciences and Peking Union Medical College Tianjin 300192 P. R. China College of Chemistry and Material Science Shandong Agricultural University Taian China Cancer Hospital and Institute; Chinese Academy of Medical Sciences Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (MOE), School of Pharmacy, Shandong University, Jinan, Shandong 250012, China Department of Pharmaceutical Sciences, Center for Drug Delivery and Nanomedicine University of Nebraska Medical Center Omaha Nebraska Department of Nephrology West China Hospital of Sichuan University Sichuan China CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, PR China Department of Drug Discovery and Biomedical Sciences, College of Pharmacy, University of South Carolina , Columbia , SC 29208, USA State Key Laboratory for Physical Chemistry of Solid Surfaces Collaborative Innovation Center of Chemistry for Energy Materials (iChEM) National & Local Joint Engineering Research Center of Preparation Technology of Nanomaterials College of Chemistry and Chemical Engineering Pen‐Tung Sah Institute of Micro‐Nano Science and Technology College of Energy Jiujiang Research Institute Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province (IKKEM) Xiamen University ... Otolaryngology department, Longyan First Affiliated Hospital of Fujian Medical University, Longyan 364000, Fujian, China. Department of Gynecology and Obstetrics Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei China; Faculty of Reproductive Medical Center of the Third Hospital Zhengzhou University Zhengzhou Henan China Department of Medical Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine Sun Yat‐sen University Cancer Center Guangzhou China Center for Biophysics and Quantitative Biology, University of Illinois, Urbana, IL 61801; Department of Biochemistry, University of Illinois, Urbana, IL 61801; Beckman Institute for Advanced Science and Technology, University of Illinois, Urbana, IL 61801 Fujian Provincial Key Laboratory on Haematology, Fujian Medical University Union Hospital, Fujian Institute of Haematology, Fuzhou, Fujian 350001, P.R. China Affiliated Hospital of Qingdao University, China Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Institute of Ophthalmology, Beijing Ophthalmology & Vision Science Key Lab., Beijing 100730, China. Oncology Research, Amgen Research, Thousand Oaks, CA 91320 School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China Institute of Medicine and Materials Applied Technologies, College of Chemistry and Chemical Engineering, Qufu Normal University, Qufu, Shandong 273165, P. R. China Department of Neurology, Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese Medicine, Nanjing, Jiangsu 210004, P.R. China Hoffmann Institute of Advanced Materials Shenzhen Polytechnic 7098 Liuxian Blvd, Nanshan District Shenzhen 518055 People's Republic of China; Department of Chemistry and Chemical Biology Rutgers University 123 Bevier Road Piscataway New Jersey 08854 USA Department of Pathology, Kingmed Diagnostics, Guangzhou Medical University Guangzhou, China. Authors' Affiliations: 1Oncology iMED, 2Imaging, Personalized Healthcare and Biomarkers, AstraZeneca, Cheshire, United Kingdom; and 3Innovation Center China, AstraZeneca, Shanghai, China Department of Sexual Medicine , Wuhu, China; Yijishan Hospital , Wuhu, China; Wannan Medical College , Wuhu, China State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210023, Jiangsu, China Department of Psychiatry Xiangya Hospital Central South University Changsha China State Key Laboratory of Cardiovascular Disease, China Oxford Centre for International Health Research, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China. Department of Cardiology The General Hospital of Northern Theater Command Shenyang China State Key Laboratory of Electroanalytical Chemistry Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun Changchun 130022 P. R. China Department of Genetics and Cell Biology, College of Life Sciences, Nankai University, 300071 Tianjin, China; Key Laboratory of Bio-resources and Eco-environment (Ministry of Education), College of Life Sciences, Sichuan University , Chengdu, Sichuan, China School of Chemistry and Chemical Engineering; South China University of Technology; Guangzhou 510641; P. R. China College of Pharmacy Seoul National University Seoul Korea Institute of Biomechanics and Medical Engineering, School of Aerospace Engineering, and ‡Cell Imaging Platform of Protein Research Technology Center, Tsinghua University, Beijing 10084, People’s Republic of China; State Key Laboratory for Turbulence and Complex System, and Department of Mechanics and Engineering Science, College of Engineering, and ⊥Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, People’s Republic of China Research Center of Laser Fusion; China Academy of Engineering Physics; Mianyang, P. R. China Center for Marine Biotechnology and Biomedicine Scripps Institution of Oceanography, University of California San Diego, 9500 Gilman Dr La Jolla CA 92093 USA The Key Laboratory of Fuel Cell Technology of Guangdong Province; School of Chemistry and Chemical Engineering; South China University of Technology; Guangzhou 510641; China School of Pharmaceutical Science Jiangnan University Wuxi Jiangsu Province People's Republic of China Global Centre for Land Based Innovation University of Western Sydney Penrith NSW 2751 Australia; Hawkesbury Institute for the Environment University of Western Sydney Penrith NSW 2751 Australia; Beijing Key Laboratory of Wetland Ecological Function and Restoration Institute of Wetland Research Chinese Academy of Forestry Beijing 100091 China State Key Laboratory of Heavy Oil Processing and Centre for Bioengineering and Biotechnology, China University of Petroleum (East China), Qingdao 266580, PR China Key Laboratory for Liquid−Solid Structural Evolution & Processing of Materials (Ministry of Education), Research Center for Carbon Nanomaterials, School of Materials Science and Engineering, Shandong University, Jinan 250061, China Plant Biochemistry Laboratory, Department of Plant Biology and Villum Kann Rasmussen Research Centre for Pro-Active Plants, Faculty of Life Sciences, University of Copenhagen, DK–1871 Frederiksberg C, Denmark (J.L., B.G.H., B.A.H.); and Department of Plant Sciences, University of California, Davis, California 95616–8780 (J.A.O., D.J.K.) Department of Neurology Daping Hospital Third Military Medical University Chongqing China Colgate-Palmolive Company, 909 River Road Piscataway, New Jersey 08854, Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, New Jersey 08854, Department of Chemistry and Biochemistry, Northern Illinois University, DeKalb, Illinois 60115, and State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian 350002, P. R. China Triticeae Research Institute, Sichuan Agricultural University, Wenjiang, Chengdu, Sichuan 611130, P. R. China West China Hospital, Sichuan University, Chengdu, Sichuan, China Tang Center for Herbal Medicine Research, Pritzker School of Medicine, University of Chicago, Chicago, IL, 60637, USA Center for Functional Nanomaterials, Brookhaven National Laboratory, Upton, New York 11973, United States; Department of Materials Science and Engineering, Stony Brook University, Stony Brook, New York 11794, United States Department of Neurosurgery Tianjin Medical University General Hospital Tianjin China; Tianjin Neurological Institute, Key Laboratory of Post‐Neuroinjury Neuro‐Repair and Regeneration in Central Nervous System Ministry of Education and Tianjin Tianjin China Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210028, P.R. China Karmanos Cancer Institute Wayne State University School of Medicine Detroit MI USA The Ninth Peoples Hospital of Chongqing, Chongqing, China Institute of Biomedical Engineering College of Medicine Southwest Jiaotong University Chengdu 610031 China State Key Laboratory of Food Nutrition and Safety Tianjin University of Science and Technology (TUST) Tianjin China Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, Beijing, China State Key Laboratory of Heavy Oil Processing & Centre for Bioengineering and Biotechnology, China University of Petroleum (East China), Qingdao 266555, China State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China Department of Food Science and Technology, College of Light Industry and Food Engineering, Nanjing Forestry University, Nanjing, China Departments of Radiation Oncology, Department of Rheumatology, Jiangsu University Affiliated Hospital, Zhenjiang City, China School of Marine Science and Engineering Hainan Provincial Key Lab of Fine Chemistry School of Physics and Optoelectronic Engineering Hainan University Haikou 570228 China State Key Laboratory of Reproductive Medicine (Q.L., H.H., X.G., R.H., Y.B., J.L., J.S.), Nanjing Medical University, Nanjing 210029, China Department of Pediatric Intensive Care Unit Jiangxi Provincial Children's Hospital Nanchang China Department of Acupuncture, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine Department of Nutrition and Food Hygiene, School of Public Health, Hebei Medical University, Shijiazhuang 050017, China. From the State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health; Department of Allergy and Clinical Immunology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China Guangdong Provincial Key Laboratory for Plant Epigenetics, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen, Guangdong 518060, P.R. China; Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Optoelectronic Engineering, Shenzhen University, Shenzhen, Guangdong 518060, P.R. China Department of Respiratory Medicine Zhongshan Hospital Fudan University Shanghai P.R. China Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100193, China Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China Department of Clinical Laboratory, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266003, China Department of Chemistry and Biochemistry, Ohio University, Athens, Ohio 45701 School of Environmental and Materials Engineering College of Engineering Shanghai Polytechnic University Shanghai 201209 P. R. China; Shanghai Innovation Institute for Materials Shanghai 200444 P. R. China; Research Center of Resource Recycling Science and Engineering Shanghai Polytechnic University Shanghai 201209 P. R. China School of Chemistry and Xi’an Key Laboratory of Sustainable Energy Materials Chemistry, Xi’an Jiaotong University, Xi’an 710049, P. R. China State Key Laboratory of High-Efficiency Coal Utilization and Green Chemical Engineering College of Chemistry and Chemical Engineering Ningxia University 750021 Yinchuan Ningxia P. R. China Department of Tumor Surgery, The First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233000, P.R. China Department of Respiratory and Critical Care Medicine, The Second Xiangya Hospital Central South University Changsha Hunan China; Research Unit of Respiratory Disease Central South University Changsha Hunan China; Diagnosis and Treatment Center of Respiratory Disease Central South University Changsha Hunan China Center for Molecular Virology, CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China Northwestern Polytechnical University School of Mechatronics, , Xi'an, Shaanxi 710072, China Laboratory of Inorganic Materials Chemistry (CMI), University of Namur , Belgium School of Physics and Physical Engineering, Qufu Normal University, 273165 Qufu, China Center for Reproductive Medicine, Henan Province Key Laboratory of Reproduction and Genetics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China; Academy of Medical Science, Zhengzhou University, Zhengzhou, Henan, 450052, China Department of Healthcare Policy and Research, Weill Cornell Medical College, Cornell University, New York, NY, USA Department of Radiology, Beijing Tongren Hospital, Capital Medical University, Beijing, China; the Affiliated Hospital of Hebei University of Engineering Handan China Department of Parasitology, Xiangya School of Medicine, Central South University, Changsha 410013, China Department of Chemistry and Chemical Biology, Rutgers University, New Jersey 08854, United States Department of Pathology, PLA Army General Hospital, Beijing, China College of Biology; College of Chemistry and Chemical Engineering; State Key Laboratory of Chemo/Biosensing and Chemometrics; Key Laboratory for Bio-Nanotechnology and Molecular Engineering of Hunan Province; Hunan University Center for Molecular Metabolism, School of Environmental and Biological Engineering, Nanjing University of Science & Technology, Nanjing 210094, China Department of Chemistry National University of Singapore 3 Science Drive 3 Singapore 117543 Singapore Screening & Protein Sciences, Merck Research Labs, Merck & Co., Inc., North Wales, PA, USA. Department of Endocrinology and Metabolism, Institute of Endocrine, Liaoning Provincial Key Laboratory of Endocrine Diseases The First Hospital of China Medical University Shenyang China NASA Ames Research Center, Moffett Field, California 94035-1000 West China Hospital, Sichuan University; Chinese Cochrane Centre; No. 37, Guo Xue Xiang Chengdu Sichuan China 610041 Shandong Provincial Key Laboratory for Biology of Vegetable Diseases and Insect Pests, College of Plant Protection, Shandong Agricultural University, Tai’an, 271018, China State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi Key Laboratory of Stomatology, Department of Prosthodontics, School of Stomatology, The Fourth Military Medical University, Xi’an, Shaanxi 710032, China West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, China; Department of Infectious Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK State Key Laboratory of Vegetation and Environmental Change Institute of Botany Chinese Academy of Sciences Xiangshan Beijing 100093 China; University of Chinese Academy of Sciences Yuquanlu Beijing 100049 China State Key Laboratory of Supramolecular Structure and Materials College of Chemistry Jilin University Changchun 130012 China College of Life Sciences Northwest University Xi'an China Beijing Germari Medical Equipment Co., Ltd, Beijing, China Department of Epidemiology and Biostatistics, School of Public Health, Tianjin Medical University, Tianjin, China Department of Infectious Diseases and Hepatology The Second Hospital of Shandong University Jinan China College of Food Science and Engineering, Qingdao Agricultural University, Qingdao 266109, China; Qingdao Special Food Research Institute, Qingdao 266109, China School of Economics, Minzu University of China, Beijing 100081, China State Key Laboratory of Crop Biology, College of Life Sciences, Shandong Agricultural University Department of Gynecologic Oncology, Sun Yat‐sen Memorial Hospital Sun Yat‐sen University Guangzhou China Division of Endocrinology and Metabolism, Virginia Commonwealth University, Richmond, Virginia 23298 Department of Biology, Johns Hopkins University, Baltimore, United States; TC Jenkins Department of Biophysics, Johns Hopkins University, Baltimore, United States Department of Bioinformatics and Biostatistics, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China. Zilkha Neurogenetic Institute, Los Angeles, CA, 90089, USA. School of Forensic Medicine Shanxi Medical University Jinzhong Shanxi P. R. China Department of Chemical Engineering; Sichuan University; Chengdu 610065; China Department of General Medicine, Sichuan Cancer Hospital, Chengdu 610041, China Department of Pulmonary and Critical Care Medicine, The First People's Hospital of Yunnan Province. The Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan, 650000 China; Department of Pulmonary and Critical Care Medicine, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, Guangdong, 510080 China Department of Critical Care Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing, China Wuhan Institute of Biological Products, Wuhan 430060, Hubei, China. Key Laboratory of Petroleum Resources, Gansu Province, Northwest Institute of Eco-Environment and Resources, Chinese Academy of Sciences, Lanzhou 730000, P. R. China State Key Laboratory of Plant Cell and Chromosome Engineering CAS Centre for Excellence in Molecular Plant Biology Institute of Genetics and Developmental Biology Chinese Academy of Sciences Beijing 100101 China; University of Chinese Academy of Sciences Beijing 100039 China Key Laboratory of Bio-Resources and Eco-Environment (Ministry of Education), College of Life Sciences, Sichuan University, Chengdu, Sichuan, China; Institute of Animal Genetics and Breeding, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, Sichuan, China Evidence-Based Social Science Research Center, School of Public Health, Lanzhou University, Lanzhou, 730000, China Key Laboratory of the Ministry of Education for Coastal and Wetland Ecosystems, College of the Environment and Ecology, Xiamen University , Xiangan South Road, Xiangan district, Xiamen, Fujian 361102 , P. R. China CAS Key Laboratory of Tropical Plant Resources and Sustainable Use, Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences, Kunming, China College of Chemistry and Life Sciences, Zhejiang Normal University, Jinhua 321004, PR China; Jiaxing Key Laboratory of Molecular Recognition and Sensing; College of Biological, Chemical Sciences and Engineering, Jiaxing University, Jiaxing 314001, PR China State Key Laboratory of Toxicology and Medical Countermeasures Beijing Institute of Pharmacology & Toxicology Beijing 100850 P. R. China College of Food Science and Technology, Nanjing Agricultural University, Nanjing, 210095, People’s Republic of China Department of Epidemiology and Biostatistics, School of Public Health, Guangdong Pharmaceutical University, Guangzhou, China Department of Radiology, Changhai Hospital Navy Medical University Shanghai China Department of Medical Imaging Sun Yat‐sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine Guangzhou Guangdong China Chinese Academy of Sciences Key Laboratory of Receptor Research, National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China Department of General Surgery Third Affiliated Hospital of Chongqing Medical University (Gener Hospital) Chongqing China Pathology and Clinical Laboratories First People's Hospital of Foshan Foshan Guangdong China Acupuncture Department, Yueyang Hospital Affiliated to Shanghai University of TCM, Shanghai 200437, China. lj0806@hotmail.com Department of Ophthalmology Guangdong Women And Children Hospital Guangzhou Guangdong China College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China. Department of Otolaryngology, Head and Neck Surgery, The Second Affiliated Hospital of Jilin University Changchun, Jilin, China. Hainan Key Laboratory of Tropical Oil Crops Biology/Coconut Research Institute, Chinese Academy of Tropical Agricultural Sciences, Av. Wenqing No. 496, Wenchang, Hainan 571339, P. R. China Department of Central Laboratory, China-Japan Union Hospital, Jilin University, 126 Xiantai Street, Changchun 130033, P. R. China School of Life Sciences, North China University of Science and Technology, Caofeidian District, Tangshan, Hebei, China 063210; Center for Genomics and Computational Biology, North China University of Science and Technology, Caofeidian Dist., Tangshan, Hebei, China 063210 State Key Laboratory of Reproductive Medicine Nanjing Medical University Nanjing Jiangsu 211166 China Department of Pharmacy, People's Hospital of Chongqing Banan District, Chongqing 401320, China. Department of Child and Adolescent Health, School of Public Health, Medical College of Soochow University, Suzhou, Jiangsu, China (mainland) International Institute for Earth System Sciences, Nanjing University, Nanjing, Jiangsu, China Key Laboratory of Luminescent and Real-Time Analytical Chemistry, Ministry of Education (Southwest University), College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, China School of Electronic Science and Engineering, Nanjing University, Nanjing 210093, China Department of Ophthalmology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Department of Liver Disease and Digestive Interventional Radiology, National Clinical Research Center for Digestive Diseases, Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi’an Viikki Biocenter Division of Genetics Department of Biosciences University of Helsinki FI‐00014 Helsinki Finland The Key Laboratory of Biomedical Information Engineering of Ministry of Education, Institute of Biomedical Engineering, School of Life Science and Technology Xi’an Jiaotong University, 28 Xianning West Road, Xi’an, Shaanxi 710049, P. R. China; National Engineering Research Center for Healthcare Devices, Guangzhou, Guangdong 510500, P. R. China; The Key Laboratory of Neuro-Informatics and Rehabilitation Engineering of Ministry of Civil Affairs, Xi’an Jiaotong University, 28 Xianning West Road, Xi’an, Shaanxi 710049, P. R. China; Department of Anesthesiology, Honghui Hospital, Xi’an Jiaotong University, 555 Youyi East Road, Xi’an, Shaanxi 710054, P. R. China Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing 100730, China. Division of Neurology Xiangya Hospital State Key Laboratory of Food Science and Technology, Institute for Advanced Study, University of Nanchang, Nanchang 330047, Jiangxi, People’s Republic of China Sustainable Energy Laboratory; Faculty of Materials Science and Chemistry; China University of Geosciences; Wuhan; China Department of Acupuncture-Moxibustion, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China Department of Neurology, Zhongshan Hospital, Fudan University, Shanghai, China Department of Systems Ecology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, 100085, Beijing, China Department of Electrical and Computer Engineering, University of Minnesota, Minneapolis, Minnesota 55455, United States Shenyang National Laboratory for Materials Science (SYNL); Institute of Metal Research (IMR); Chinese Academy of Sciences (CAS); Shenyang; China Department of Chemistry Key Laboratory of Environmentally Friendly Chemistry and Applications of Ministry of Education Xiangtan University Hunan Province China P. R. China Department of General Surgery Gansu Provincial Hospital Gansu China Department of Hematology, First Affiliated Hospital of Xi’an Jiaotong University, Shaanxi, China Key Laboratory of Dental Maxillofacial Reconstruction and Biological Intelligence Manufacturing, School and Hospital of Stomatology, Lanzhou University, Lanzhou, Gansu Province, 730000, People's Republic of China Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH, 44106, USA. jingli@cwru.edu. College of Science, Shenyang University of Chemical Technology, Shenyang, 110142, P. R. China State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China Division of Nephrology Guangdong Provincial People’s Hospital Guangdong Academy of Medical Sciences Guangzhou China; Southern Medical University Guangzhou China Research Fellow, Department of Anesthesiology, Perioperative and Pain Medicine, Children's Hospital Boston and Harvard Medical School, and Department of Histology and Embryology, Laboratory of Stem Cell and Tissue Engineering, Chongqing Medical University. Department of Physiology and Pathophysiology, Key Laboratory of Molecular Cardiovascular Science, Peking (Beijing) University Health Science Center, Beijing, China Department of Chemistry National University of Singapore Singapore 117543 Singapore Real-World Solutions, IQVIA, Durham, North Carolina Department of Cardiovascular Surgery, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China Department of Critical Care Medicine, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China State Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, P. R. China; Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Weijin Road 94#, Nankai District, Tianjin 300071, P. R. China Contribution from the Department of Chemical and Biomolecular Engineering, Faculty of Engineering, and Department of Mechanical and Production Engineering, Faculty of Engineering, National University of Singapore, 10 Kent Ridge Crescent, Singapore 119260 Department of Evidence-Based Medicine and Clinical Epidemiology, West China Hospital, Sichuan University, Chengdu City, Sichuan Province, PR China; The Chinese Cochrane Center, Chengdu City, Sichuan Province, PR China Department of Radiology, Changhai Hospital of Shanghai, The Second Military Medical University, Shanghai, China Department of Radiation Medicine and Protection, Faculty of Preventive Medicine, Airforce Medical University, Xi'an, Shaanxi 710032, P.R. China Department of Chemical and Biomolecular Engineering and KAUST-NUS GCR Program and ‡Department of Electrical and Computer Engineering, Faculty of Engineering, National University of Singapore, 10 Kent Ridge Crescent, Singapore 119260 Department of Chemical Engineering and Safety, Binzhou University, Binzhou 256603, China and Engineering Research Center for Wastewater Resource of Shandong Province, Binzhou 256603, China Institute of Diagnostic and Interventional Radiology Shanghai Jiao Tong University Affiliated Sixth People's Hospital Shanghai China Department of Physics/Pen-Tung Sah Institute of Micro-Nano Science and Technology, Xiamen University, Xiamen, Fujian 361005, China Laboratory of Stem Cells and Tissue Engineering, Basic Medical College, Chongqing Medical University, Chongqing 400016, China Department of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Affiliated Hospital of China Medical University, Shenyang, 110001, China Yunnan Key Laboratory of Screening and Research on Anti-pathogenic Plant Resources from Western Yunnan, Dali University , Dali 671000 , People’s Republic of China; Institute of Materia Medica and College of Pharmacy, Dali University , Dali 671000 , People’s Republic of China College of Agriculture, Kunming University , Kunming 650214 , People’s Republic of China Department of Cardiology Beijing Chaoyang Hospital Capital Medical University Beijing China Division of Life Sciences and Medicine, The First Affiliated Hospital of USTC University of Science and Technology of China Hefei Anhui China Department of Medicinal and Applied Chemistry, Kaohsiung Medical University, No. 100, Shiquan 1st Rd, Sanmin District, Kaohsiung City, 807, Taiwan Department of Gynecologic Oncology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China (mainland) Department of Electrical Engineering and Computer Science, Case Western Reserve University Cleveland, OH, USA Biologics Discovery, WuXi Biologics, Waigaoqiao Free Trade Zone, Shanghai, China Key Laboratory of Resource Biology and Biotechnology in Western China (Northwest University) Ministry of Education Xi’an China Department of Pharmacology, Medical school of Xi'an Jiaotong University, Xi'an 710061, China. Center for Drug Delivery and Nanomedicine, Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha Nebraska 68198, United States Department of General Internal Medicine, Sichuan Cancer Hospital and Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China From the Multidisciplinary Cardiovascular Research Centre (E.A.-S., J.N., H.T., K.R., C.J.M., D.O., K.E.P., J.L., and D.J.B.), University of Leeds, Leeds, England; the Institute of Membrane and Systems Biology (E.A.-S., J.N., H.T., C.J.M., J.L., and D.J.B.), Faculty of Biological Sciences, University of Leeds, Leeds, England; the Faculty of Medicine and Health (K.R. and K.E.P.), University of Leeds, Leeds, England; and the Department of Cardiac Surgery (D.O.), Leeds General Infirmary, Leeds, England. Department of Pediatrics, Jingzhou Traditional Chinese Medicine Hospital of Hubei Province, Jingzhou, China Department of Neurology, First People’s Hospital of Zunyi City and Third Affiliated Hospital of Zunyi Medical College, Zunyi 563002, Guizhou, China Department of Oral and Maxillofacial & Head and Neck Oncology, Beijing Stomatological Hospital Capital Medical University Beijing China Department of Oral and Maxillofacial & Head and Neck Oncology Beijing Stomatological Hospital Capital Medical University Beijing China Key Laboratory of Conservation Biology on Endangered Wildlife of Sichuan Province, College of Life Sciences, Sichuan University, Chengdu, China, Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305-5345, USA Department of Orthodontics Peking University School and Hospital of Stomatology Beijing China; National Clinical Research Center for Oral DiseasesNational Engineering Laboratory for Digital and Material Technology of Stomatology Beijing China; Beijing Key Laboratory of Digital Stomatology Beijing China Department of Geriatrics, the Second Affiliated Hospital, Harbin Medical University , Harbin, China Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, CA 94305 College of Life Science and Bioengineering, Beijing University of Technology, Beijing 100124, P.R.China. Department of Radiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School , Nanjing University , Nanjing , Jiangsu , 210008 , China; Institute of Medical Imaging and Artificial Intelligence , Nanjing University , Nanjing , Jiangsu , 210008 , China; Medical Imaging Center, The Affiliated Drum Tower Hospital , Medical School of Nanjing University , Nanjing , Jiangsu , 210008 , China State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases West China Hospital of Stomatology Sichuan University Chengdu Sichuan China State Key Laboratory of Protein and Plant Gene Research, College of Life Science, Peking University Beijing 100871, China. State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Research Unit of Oral Carcinogenesis and Management Chinese Academy of Medical Sciences, West China Hospital of Stomatology, Sichuan University Chengdu China Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of TCM, Shanghai 200030, China. School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China School of Biological and Chemical Engineering, Jiangsu University of Science and Technology, Zhenjiang 212018, China Department of Endocrinology, Nanshan Affiliated Hospital of Guangdong Medical College, Shenzhen 518052, China State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, South China Agricultural University, 510642 Guangzhou, China;; Key Laboratory of Plant Functional Genomics and Biotechnology of Guangdong Provincial Higher Education Institutions, South China Agricultural University, 510642 Guangzhou, China;; College of Life Sciences, South China Agricultural University, 510642 Guangzhou, China Eye Institute of Xiamen University Xiamen, Fujian, China 2Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Xiamen, Fujian, China School of Pharmacy, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China Department of Food and Nutrition, Hallym University, Chuncheon, Korea; and Citrus Research Institute Southwest University Chongqing China; Laboratory of Citrus Quality and Safety Risk Assessment for Citrus Products Ministry of Agriculture and Rural Affairs Chongqing China; Quality Supervision and Testing Center for Citrus and Seedling Ministry of Agriculture and Rural Affairs Chongqing China National Health Commission Key Laboratory of Clinical Research for Cardiovascular Medications, Beijing, China; State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Beijing, China; Fuwai Hospital, Chinese Academy of Medical Sciences, Beijing, China; Peking Union Medical College, Beijing, China; National Clinical Research Center of Cardiovascular Diseases, Beijing, China Department of Cardiology General Hospital of Shenyang Military Region Shenyang China NHC Key Laboratory of Clinical Research for Cardiovascular Medications National Clinical Research Center of Cardiovascular Diseases Fuwai Hospital National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China; Central China Subcenter of the National Center for Cardiovascular Diseases Henan China Tianjin Key Laboratory for Modern Drug Delivery and High Efficiency, School of Pharmaceutical Science and Technology Tianjin University Tianjin People’s Republic of China; Key Laboratory of Systems Bioengineering, Ministry of Education Tianjin University Tianjin People’s Republic of China College of Environmental and Civil Engineering, Jiangnan University, Wuxi 214122, China. Department of Radiology, the Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, 127 Dongming Rd, Zhengzhou 45008, China. State Key Laboratory of Natural Medicines, Jiangsu Provincial Key Laboratory for TCM Evaluation and Translational Research, Department of TCM Pharmacology, School of Traditional Pharmacy, China Pharmaceutical University, Nanjing, China School of Chemistry and Chemical Engineering, Yancheng Institute of Technology, Yancheng 224051, China School of Life Science and Biotechnology, Shanghai Jiao Tong University, 800 Dong Chuan Road, Shanghai 200240, China; Shanghai Center for Bioinformation Technology, 1278 Ke Yuan Road, Shanghai 201203, China School of Chemical and Biomolecular Engineering, The University of Sydney, Sydney, New South Wales 2006, Australia Education College, Tianjin Normal University, Institute of Psychology, Chinese Academy of Sciences, Graduate University of Chinese Academy of Science Department of Hospital Infection Chengdu Women's and Children's Central Hospital School of Medicine University of Electronic Science and Technology of China Chengdu China Institute of Medical Biology, Chinese Academy of Medical Sciences, Peking Union Medical College, Kunming, China; National Local Joint Engineering Research Center for Biological Products of Viral Infectious Diseases Key Laboratory of Medicinal and Edible Plants Resources Development of Sichuan Education Department, School of Pharmacy, Chengdu University, Chengdu, China The Key Laboratory of Animal Genetic Resource and Breeding Innovation, College of Coastal Agricultural Sciences, Guangdong Ocean University, Zhanjiang 524088, China; The Key Laboratory of Animal Resources and Breed Innovation in Western Guangdong Province, Zhanjiang 524088, China State Key Laboratory of Polymer Physics and Chemistry, CAS Key Lab of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080, China College of Coastal Agricultural Sciences, Guangdong Ocean University, Zhanjiang 524088, China; The Key Laboratory of Animal Resources and Breed Innovation in Western Guangdong Province, Zhanjiang 524088, China Department of Molecular Pharmacology, School of Medicine, Nankai University, Tianjin, China State Key Laboratory of Solid Lubrication, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, People’s Republic of China Advanced Materials Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250014, China; Shandong Provincial Key Laboratory of High Strength Lightweight Metallic Materials, Advanced Materials Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250014, China State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, China State Key Laboratory of Efficient Production of Forest Resources, College of Biological Science and Technology, Beijing Forestry University, Beijing 100083, China Aviation and Diving Medical Center Navy General Hospital Beijing China Department of Science and Education Shenyang Maternity and Child Health Hospital Shenyang China The State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Weijin Road 94#, Nankai District, Tianjin, P. R. China State Key Laboratory of Coordination Chemistry, Jiangsu Key Laboratory of Advanced Organic Materials, School of Chemistry and Chemical Engineering, Collaborative Innovation Center of Advanced Microstructures, Nanjing University, Nanjing 210023, China Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, and Jim Ayers Institute for Precancer Detection and Diagnosis, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 Department of Materials Science and Engineering University of Pennsylvania Philadelphia PA 19104 USA Department of Burns and Plastic Surgery Second Affiliated Hospital of Air Force Medical University Xi'an P.R. China School of Life Sciences, Yichuang Biotechnology Industry Research Institute, Beijing Yizhuang Biomedical Park, Daxing District Beijing China Department of Respiratory Medicine The Petroleum Clinical Medical College of Hebei Medical University Langfang Hebei China Department of Gynecology and Obstetrics, Tongji hospital, Tongji Medical College, Huazhong Science and Technology University, Wuhan 430030, China. Department of Endocrinology and Metabolism, Zhongshan Hospital Fudan University Shanghai China Key Laboratory of Marine Drugs, Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China School of Environment, Nanjing Normal University, Nanjing, People’s Republic of China The Second Clinical College, Guangzhou University of Chinese Medicine, Guangzhou 510120, China Pediatric Department, Yancheng Third People's Hospital, Yancheng School of Clinical Medicine of Nanjing Medical University, Yancheng, Jiangsu 224000, P.R. China Chinese Evidence-Based Medicine Center, West China Hospital, Sichuan University College of Chemistry, Zhengzhou University, No. 100 of Science Road, Zhengzhou, Henan 450001, P. R. China Beijing Protein and Antibody R&D Engineering Center Sinocelltech Ltd. Beijing 100176 P. R. China Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Shenzhen Graduate School of Peking University, Shenzhen 518055, China Center for Translational Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi’an, Shaanxi 710061, People’s Republic of China Department of Gynecology, Tianjin First Center Hospital, Tianjin, P.R. China Industrial Engineering, Arizona State University, Tempe, AZ, USA; Department of Science and Education, Shenyang Maternity and Child Health Hospital, Shenyang, China Department of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. lijing7405@126.com Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Engineering Plastics, CAS, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China State Key Joint Laboratory of Environmental Simulation and Pollution Control, College of Environmental Sciences and Engineering, Peking University, Beijing 100871, China Department of Interventional Radiology School of Food and Biological Engineering, Chengdu University, Chengdu 610106, P. R. China Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China Department of Physiology, Jiamusi University School of Basic Medical Sciences, Jiamusi, China. Department of Gynaecological Oncology, Sun Yat‐sen Memorial Hospital Sun Yat‐sen University Guangzhou China Department of Respiratory Tract Medicine, The Petroleum Clinical Medical College of Hebei Medical University, Langfang, Hebei 065000, P.R. China State Key Laboratory of Materials-Oriented Chemical Engineering, College of Chemistry and Chemical Engineering, Nanjing Tech University, Nanjing 210009, PR China School of Chemistry and Materials Science Jiangsu Key Laboratory of New Power Batteries Jiangsu Collaborative Innovation Centre of Biomedical Functional Materials Nanjing Normal University Nanjing 210023 P. R. China Department of Nursing, The First Affiliated Hospital, Jinan University, Guangzhou, China. Department of Hematology, Zhongshan Hospital, Fudan University, Shanghai, China Department of Biostatistics, Richard M. Fairbanks School of Public Health, Indiana University, Indianapolis, IN, USA Institute of Cardiovascular Science, Peking University Health Science Center, Beijing, China Endocrinology, 2011 Collaborative Innovation Center of Tianjin for Medical Epigenetics, Key Laboratory of Hormones and Development (Ministry of Health), Metabolic Diseases Hospital and Tianjin Institute of Endocrinology, Tianjin Medical University, No. 66, Tongan Road, Heping District, Tianjin 300070, China Department of Ophthalmology, Yangpu Hospital, Tongji University School of Medicine, Shanghai, China Department of Pediatrics Beijing Tongren Hospital, Capital Medical University Beijing China Key Laboratory of Bio-resources and Eco-environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, People’s Republic of China Department of Rheumatology and Clinical Immunology, Chinese Academy of Medical Sciences & Peking Union Medical College; National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Ministry of Science & Technology; State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital (PUMCH); Key Laboratory of Rheumatology and Clinical Immunolo Cancer Therapy Center Affiliated Hospital of the Academy of Military Medical Sciences Beijing China Department of Orthopedic Surgery, University of Alberta, Edmonton, AB, Canada From the Department of Hypertension and Vascular Disease, The First Affiliated Hospital (W.H.X., Z.Y., S.Y.X., L.C., X.Y.Z., J.L., X.L., Y.X.Q., J.T.), and Biomedical Engineering Center, School of Chemistry and Chemical Engineering (X.T.S.), Sun Yat-Sen University, Guangzhou, China. Laboratory of Functional Chemistry and Nutrition of Food; College of Food Science and Engineering; Northwest A&F University; Yangling; China Beijing Tongren Eye Center, Beijing Tongren Hospital of Capital Medical University, Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing, China Department of science and education, Shenyang Women and Children Health Care Centre, Shenyang, China Department of Pathology, Zibo Central Hospital, Zibo 255000, Shandong Province, China College of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, China; Key Laboratory of Environment Correlative Dietology (Huazhong Agricultural University), Ministry of Education, Wuhan 430070, China Key Laboratory for Molecular Genetic Mechanisms and Intervention Research on High Altitude Disease of Tibet Autonomous Region; School of Medicine; Xizang Minzu University; Xianyang; China College of Food Science and Technology, Huazhong Agricultural University Key Laboratory of Environment Correlative Dietology Ministry of Education Wuhan 430070 China CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, PR China; Savaid Medical School, University of Chinese Academy of Sciences, Beijing 100049, PR China Department of Hepatobiliary Surgery The Second Affiliated Hospital of Army Medical University No. 183 Xinqiao High Street 400037 Shapingba District, Chongqing China Phase I Clinical Trial Center, Xiangya Hospital, Central South University, Changsha, PR China Jiangsu Key Laboratory of Biofunctional Materials, College of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, P.R. China; College of Chemical and Biological Engineering, Yancheng Institute of Technology, Yancheng 224051, P.R. China Evidence-Based Medicine Center, MOE Virtual Research Center of Evidence-based Medicine at Zunyi Medical College, Affiliated Hospital of Zunyi Medical College, Zunyi 563003, Guizhou, China; Department of Neurology, First People's Hospital of Zunyi City and Third Affiliated Hospital of Zunyi Medical College, Zunyi 563002, Guizhou, China School of Energy; Yunnan University; Kunming 650091; China Institute of Beijing Infectious Diseases, Beijing 100039, China. Medicine Design, Pfizer, 610 Main Street, Cambridge, Massachusetts 02139, United States School of Chemistry, and Xi’an Key Laboratory of Sustainable Energy Materials Chemistry, Xi’an Jiaotong University, Xi’an 710049, P. R. China State Key Laboratory of Materials-Oriented Chemical Engineering; College of Chemistry and Chemical Engineering; Nanjing Tech University (former Nanjing University of Technology); Nanjing 210009; P. R. China School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou, China; SCUT-Zhuhai Institute of Modern Industrial Innovation, Zhuhai, China CAS Key Laboratory of Genome Sciences and Information, Chinese Academy of Sciences, Beijing, China Department of Cardiology, The General Hospital of Western Theater Command, Chengdu 610083, China Department of Obstetrics and Gynecology Shanghai Medical College of Fudan University Shanghai China; Department of Integrated Traditional & Western Medicine, Obstetrics and Gynecology Hospital of Fudan University Shanghai China Departmemt of Radiology, Changzhou Second People's Hospital, Affiliate to Nanjing Medical University, Changzhou 213003, China. Key Laboratory of Molecular Nanostructure and Nanotechnology and Beijing National Laboratory for Molecular Sciences; Institute of Chemistry; Chinese Academy of Sciences (CAS); Beijing 100190, P.R. China; University of CAS Department of Gastrointestinal Surgery, Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu 213003, China Department of Interventional Radiology The First Affiliated Hospital of Zhengzhou University Zhengzhou China Department of Ophthalmology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China State Key Laboratory of Materials Oriented Chemical Engineering; College of Chemical Engineering; Nanjing Tech University; Nanjing 211816; P. R. China Department of Anesthesia, West China Hospital, Sichuan University, Chengdu, China. Chongqing Key Laboratory of Biochemistry and Molecular Pharmacology Chongqing Medical University Chongqing China Unimicro (shanghai) Technologies Co., Ltd. Shanghai P. R. China Department of Cardiology, Xuanwu Hospital, Capital Medical University, Beijing, China. Wuya College of Innovation; Shenyang Pharmaceutical University; Shenyang 110016; China Proteomic Platform, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China, and Graduate University of the Chinese Academy of Sciences, Beijing, China Department of Clinical Laboratory, The First Affiliated Hospital of Nanchang University, Nanchang, China. Department of Hepatobiliary Surgery, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, P.R. China State Key Laboratory of Transient Optics and Photonics Xi'an Institute of Optics and Precision Mechanics of CAS Xi'an 710119 China; University of Chinese Academy of Sciences Beijing 100049 China; Faculty of Mathematics and Physics Huaiyin Institute of Technology Huaian 223003 China Key Laboratory of Marine Drugs, Chinese Ministry of Education; School of Medicine and Pharmacy, Ocean University of China, 5 Yushan Road, Qingdao 26003, Shandong, P. R. China School of Chemical Engineering, Sichuan University, No. 24 South Section 1, Yihuan Road, Chengdu 610065, China Department of Chemistry; State Key Laboratory of Marine Pollution (SKLMP), City University of Hong Kong, Kowloon, Hong Kong SAR, China; Research Centre for the Oceans and Human Health, City University of Hong Kong Shenzhen Research Institute, Shenzhen 518057, China Department of Psychology, Nanjing Normal University Department of Anatomy, Academy of Basic and Forensic Medicine, Jining Medical University, Shandong, China. lijing800912@yahoo.com.cn College of Pharmacy, Anhui University of Chinese Medicine, Hefei, Anhui, China Department of Infectious Diseases, Research Laboratory of Clinical Virology, Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China State Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, 190 Kaiyuan Avenue, Guangzhou 510530, China State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China College of Life Sciences Peking University Beijing 100871 China; School of Biology University of St Andrews Mitchell Building St Andrews Fife KY16 9TH UK Department of Surgery, University of Kentucky, Lexington, Kentucky; Markey Cancer Center, University of Kentucky, Lexington, Kentucky Merck and Co., Inc., Kenilworth, New Jersey 07033, United States School of Chemistry, and Xi’an Key Laboratory of Sustainable Energy Materials Chemistry, Xi’an Jiaotong University, Xi’an 710049, P.R. China College of Food Science and Engineering Liaoning Medical University Jinzhou 121000 China; Engineering Research Center for Meat Processing and Safety Control Liaoning Province China CAS Key Laboratory of Bio‐inspired Materials and Interfacial Sciences Technical Institute of Physics and Chemistry Chinese Academy of Sciences Beijing 100190 China Department of Pathogenic Biology School of Basic Medicine Qingdao University Qingdao China Division of Glycoscience, School of Biotechnology, Royal Institute of Technology (KTH), AlbaNova University Center, Stockholm, SE-106 91, Sweden Division of Cardiovascular Diseases, Mayo Clinic, Rochester; Division of Cardiology, Xuanwu Hospital Capital Medical University; Division of Cardiovascular Diseases, Mayo Clinic; Division of Cardiology, Xuanwu Hospital Capital Medical University Takeda Development Center Americas, Inc. Lexington Massachusetts USA State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China; Universite Cote d’Azur, CNRS, Inserm, IRCAN, Nice, France College of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, China Harbin Institute of Technology 1 Institute of Plasma Surface Engineering and Equipment, State Key Laboratory of Advanced Welding Production and Technology, School of Materials Science and Engineering, , Harbin 150001, People's Republic of China Department of Genetics and Biochemistry Clemson University Clemson SC USA State Administration of Traditional Chinese Medicine,Research Center of Traditional Chinese Medicine-Information Engineering,Beijing University of Chinese Medicine Beijing 100102,China. Department of Burn and Plastic Surgery Tangdu Hospital, Fourth Military Medical University Xi'an China Department of Materials Science and Engineering; Stony Brook University; Stony Brook; USA Department of Obstetrics, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266000, P.R. China Mental Health Center, West China Hospital, Sichuan University , No. 28 Dian Xin Nan Road, Chengdu, Sichuan 610041 , China Department of Hepatobiliary Surgery the Second Affiliated Hospital of Army Medical University Chongqing 400037 China Institute of Basic Medical Sciences Chinese Academy of Medical Sciences School of Basic Medicine Peking Union Medical College Center for Excellence in Tissue Engineering Chinese Academy of Medical Sciences State Key Laboratory of Common Mechanism Research for Major Diseases Beijing Key Laboratory of New Drug Development and Clinical Trial of Stem Cell Therapy Beijing 100005 China Heart Center and Beijing Key Laboratory of Hypertension, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China Technology Center, China Tobacco Yunnan Industrial Co., Ltd, Kunming 650106, China. Department of Cardiology, Beijing Hospital, Beijing 100730, China. Department of Gastroenterology and Hepatology, Tongji Hospital, School of Medicine Tongji University Shanghai China Key Laboratory of Intelligent Computing and Signal Processing of Ministry of Education and Information Materials and Intelligent Sensing Laboratory of Anhui Province, Institutes of Physical Science and Information Technology, Anhui University , Hefei , Anhui 230601 , China Infectious Disease and AIDS Research Center, Second Xiangya Hospital, Central South University, Changsha, Hunan, China. School of Marine Sciences, Sun Yat-Sen University, Guangzhou, China; South China Sea Bio-Resource Exploitation and Utilization Collaborative Innovation Center, Sun Yat-Sen University, Guangzhou, China College of Horticulture, Nanjing Agricultural University, Nanjing 210095, China. lijing.hs@163.com College of Life Sciences Henan Normal University Xinxiang China Abteilung für Molekulare Genetik, Institut für Mikrobiologie und Genetik, Göttinger Zentrum für Molekulare Biowissenschaften (GZMB), Georg-August Universität Göttingen , D-37075 Göttingen, Germany Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center , Houston, Texas , USA Department of Vascular Anomalies and Interventional Radiology, Qilu Children's Hospital of Shandong University, Jinan, Shandong 250022, P.R. China *Department of Biochemistry and State Key Lab of Food Science and Technology, Institute for Advanced Study, Nanchang University, Nanchang, Jiangxi, 330047, China The Second Clinical Medical College, Guangdong Provincial Hospital of Chinese Medicine, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou University of Chinese Medicine , Guangzhou, Guangdong 510120 , PR China Authors' Affiliations: 1The Institute of Cardiovascular Sciences and Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Peking University Health Science Center; 2The Department of Cardiovascular Medicine and the Department of Endocrinology, the Military General Hospital of Beijing; 3The Department of Cardiovascular Medicine, China-Japan Friendship Hospital; and 4Department of Hepatobiliary Surgery, West Campus, Beijing Chao-yang Hospital Affiliated to Capital Medical University, Beijing, China Department of Pharmaceutical Chemistry, University of California, San Francisco, California 94143-0446 Department of Oncology The First Affiliated Hospital of Zhengzhou University Zhengzhou China; Institute of Clinical Medicine The First Affiliated Hospital of Zhengzhou University Zhengzhou China Department of Material Chemistry, School of Chemistry, and Xi’an Key Laboratory of Sustainable Energy Materials Chemistry, Xi’an Jiaotong University, Xi’an 710049, P. R. China Department of Oncology Huashan Hospital Fudan University Shanghai China Stomatological Hospital of Chongqing Medical University. Chongqing 400015, China. E-mail:2017110892@stu.cqmu.edu.cn. Chongqing Key Laboratory of Chemical Process for Clean Energy and Resource Utilization, School of Chemistry & Chemical Engineering, Chongqing University, Chongqing 400044, P. R. China Department of Emergency Medicine, Harrison International Peace Hospital, Hengshui 053000, China.E-mail: zhiyeyishi007@sina.com.cn. Department of Biology, College of Life and Environment Science, Shanghai Normal University, Shanghai, People's Republic of China; Oncology Institute, Cardinal Bernardin Cancer Center, Loyola University Chicago, Chicago, Illinois, USA Department of Rehabilitation, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou 45000, China Department of Epidemiology and Biostatistics, School of Public Health, Indiana University Bloomington, Bloomington, IN, USA State Key Lab of New Ceramics and Fine Processing, School of Materials Science and Engineering, Tsinghua University, Beijing 100084, China College of Plant Protection Shanxi Key Laboratory of Integrated Pest Management in Agriculture Shanxi Agricultural University Taiyuan 030031 China Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China; University of Chinese Academy of Sciences, Beijing 100049, China Luoyang Key Laboratory of Live Carrier Biomaterial and Animal Disease Prevention and Control, College of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471023, China; Laboratory of Functional Microbiology and Animal Health, College of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471003, China Hoffmann Institute of Advanced Materials Shenzhen Polytechnic 7098 Liuxian Blvd., Nanshan District Shenzhen, Guangdong 518055 P. R. China; Department of Chemistry and Chemical Biology Rutgers University 123 Bevier Road Piscataway NJ 08854 USA Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China; Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology, Qingdao 266237, China; Open Studio for Drugability Research of Marine Natural Products, Pilot National Laboratory for Marine Science and Technology, Qingdao 266000, China State Key Laboratory of Polymer Physics and Chemistry, Joint Laboratory of Polymer Science and Materials, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100080, China, and Institut für Chemie/Organische Chemie, Freie Universität Berlin, Takustrasse 3, D-14195 Berlin, Germany Xi'an Medical University, Obstetrics and Gynecology Nursing Staff Room, Xi'an, China. lijing071015@126.com Wuhan University of Technology School of Chemistry, Chemical Engineering and Life Sciences, , Wuhan 430070, China School of Anesthesiology Zunyi Medical University Zunyi Guizhou China Department of Oncology, Shihezi University School of Medicine, The First Affiliated Hospital, Shihezi - China Key Laboratory for Polymeric Composite and Functional Materials of Ministry of Education School of Chemistry Sun Yat-Sen University Guangzhou 510275 China State Key Laboratory of Petroleum Resources and Prospecting, China University of Petroleum (Beijing), Beijing 102249, P. R. China Department of Ultrasound, Liaocheng People's Hospital, Liaocheng, Shandong 252000, P.R. China Department of Clinical Laboratory, The First Affiliated Hospital of Nanchang University, Nanchang 330006, China Department of Ophthalmology, Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, China School of Materials Science and Engineering, Hebei Provincial Key Laboratory of Traffic Engineering Materials, Shijiazhuang Tiedao University, Shijiazhuang, 050043, China China Pharmaceutical University School of Life Science and Technology Nanjing P. R. China Laboratoire de Chimie Organique, Université libre de Bruxelles (ULB), Avenue F.D. Roosevelt 50, CP160/06, B-1050 Brussels, Belgium College of Life Science, Southwest Forestry University , Kunming , People’s Republic of China Public Health Department of Weifang Medical University, Weifang, Shandong Province, PR China; State Key Laboratory of Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, PR China 1Surgery and Departments of Department of Epidemiology, School of Public Health, Harbin Medical University, Harbin, Heilongjiang Province, P. R. China The Sainsbury Laboratory, Norwich Research Park, Norwich, NR4 7UH, United Kingdom; and Laboratory of Immunology, Department of Biology, Tsinghua University, Protein Science Laboratory of the Ministry of Education, Beijing 100084, People's Republic of China Key Laboratory for Polymeric Composite and Functional Materials of Ministry of Education, Key Laboratory of High Performance Polymer‐based Composites of Guangdong Province School of Chemistry Sun Yat‐sen University Guangzhou 510275 China Department of Stomatology, The First Affiliated Hospital of Guangxi Medical University Nanning, Guangxi, P. R. China. State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Collaborative Innovation Center of Advanced Microstructures, Nanjing University, Nanjing 210023, China Liver Cirrhosis Study Group, Department of Gastroenterology General Hospital of Shenyang Military Area Shenyang China; Postgraduate College Dalian Medical University Dalian China College of Animal Science, Anhui Science and Technology University , Fengyang, Anhui , China; Anhui Province Key Laboratory of Animal Nutritional Regulation and Health, Anhui Science and Technology University , Fengyang, Anhui , China Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, P. R. China; Open Studio for Druggability Research of Marine Natural Products, Pilot National Laboratory for Marine Science and Technology (Qingdao), Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology, Qingdao, P. R. China School of Medicine, Tsinghua University, Beijing, China Hunan Cancer Hospital/the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, China; Department of Microbiology, School of Basic Medical Science, Central South University, Changsha, Hunan, China; The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, NHC Key Laboratory of Carcinogenesis, Cancer Research Institute, Central South University, Changsha, Hunan, China; Department of Hematology, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China; China-Africa Research Center of Infectious Diseases, Central South University, Changsha, Hunan, China Department of Pharmacy, the First Affiliated Hospital, Harbin Medical University Center for Applied Chemical Research, Frontier Institute of Science and Technology, Xi’an Jiaotong University, Xi’an 710049, China Department of Gynecologic Oncology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, China. Department of Central Laboratory, Chongqing University Three Gorges Hospital, Chongqing, China; College of Life Sciences, Chongqing Medical University, Yuzhong, China Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China; Institute of Geriatric Medicine, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China State Key Laboratory of Oral Diseases West China Hospital of Stomatology Sichuan University Chengdu China Jing Li, Lu-Ming Huang, Cheng-Wei Tang, Department of Gastroenterology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China. Operating Room, Peking University Third Hospital, Beijing, China College of Food Science and Technology; Huazhong Agricultural University; Wuhan 430070; China; Key Laboratory of Environment Correlative Dietology (Huazhong Agricultural University) Department of Infectious Diseases, Huashan Hospital Fudan University Shanghai China Department of Medicine, University of Miami Miller School of Medicine, Miami, FL 33136, USA. Center of Excellence in Tissue Engineering, Institute of Basic Medical Sciences, CAMS and PUMC, Beijing 100005, China. State Key Laboratory for Conservation and Utilization of Subtropical Agro‐Bioresources South China Agricultural University Guangzhou 510642 China; College of Life Sciences South China Agricultural University Guangzhou 510642 China Center of Digestive Endoscopy, Guangdong Second Provincial General Hospital, Guangzhou 510317, China; Integrated Chinese and Western Medicine Postdoctoral Research Station, Jinan University, Guangzhou 510632, China Department of Neurology, Daping Hospital, Third Military Medical University, Chongqing, China School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China. The State Key Laboratory of Power Transmission Equipment & System Security and New Technology; Chongqing Key Laboratory of Chemical Process for Clean Energy and Resource Utilization; School of Chemistry and Chemical Engineering; Chongqing University; Chongqing 400044 Basic Medical College Jiamusi University Jiamusi Heilongjiang China Department of Pathology and Pathophysiology, Nanjing Medical University, Nanjing 210029, China. wlbianjs@163.com Department of Pediatrics, Changchun University of Chinese Medicine, Changchun, Jilin 130021, P.R.�China College of Pharmacy, Southwest Minzu University, Chengdu, Sichuan, P.R.China Department of Medical Oncology, China Meitan General Hospital, Beijing - PR China State Key Laboratory of Food Science and Technology Nanchang University Nanchang 330047 People's Republic of China Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, Hunan, PR China Department of Pediatric Dentistry, Peking University School and Hospital of Stomatology, Beijing 100081, P.R. China Department of Bioengineering, Rice University , Houston, TX 77005, USA Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology , Wuhan, Hubei, 430030, People’s Republic of China; Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology , Wuhan, Hubei, 430030, People’s Republic of China Preston Robert Tisch Brain Tumor Center, Duke Medical Center, Durham, North Carolina, USA; ; Department of Surgery (Neurosurgery), Duke Medical Center, Durham, North Carolina, USA; College of Veterinary Medicine, Yangzhou University, Yangzhou 225012, China National Institute for Communicable Disease Control and Prevention, State Key Laboratory for Communicable Disease Prevention and Control, Chinese Center for Disease Control and Prevention, Beijing 102206, China. Animal Nutrition Institute Sichuan Agricultural University Chengdu 611130 P. R. China; Key Laboratory for Animal Disease‐Resistant Nutrition of the Ministry of Education of China Sichuan Agricultural University Chengdu 611130 P. R. China; Key Laboratory of Animal Disease‐Resistant Nutrition of Sichuan Province Sichuan Agricultural University Chengdu 611130 P. R. China Zhejiang Provincial Hospital, Hangzhou, Zhejiang, China Department of Endocrinology, Zhengzhou Central Hospital, Zhengzhou University, Zhengzhou 450007, P.R. China State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China School of Design and Art, Henan University of Technology, Zhengzhou, China Key Laboratory of Functional Inorganic Material Chemistry Ministry of Education and School of Chemistry and Material Science Heilongjiang University 74 Xuefu Road Harbin 150080 China The Chinese University of Hong Kong, Department of Psychiatry, Hong Kong, China Department of Oncology, Xuzhou Cancer Hospital, Xuzhou, China Department of Infectious Diseases The Fifth Medical Center of Chinese PLA General Hospital, National Clinical Research Center for Infectious Diseases Beijing China Mental Health Center, West China Hospital of Sichuan University, Chengdu, China The Second General Surgery Hebei Medical University Fourth Affiliated Hospital and Hebei Provincial Tumor Hospital Shijiazhuang Hebei China Heart Center, Beijing Chaoyang Hospital Capital Medical University Beijing China; Beijing Key Laboratory of Hypertension, Beijing Chaoyang Hospital Capital Medical University Beijing China Department of Chemistry and Chemical Biology Rutgers University 123 Bevier Road Piscataway NJ 08854 USA Department of Chemistry, Zhengzhou University, Zhengzhou 450001, P. R. China, and Sciences Chimiques de Rennes, UMR 6226 CNRS, Université de Rennes 1, Campus de Beaulieu, 35042, Rennes Cedex, France Key Laboratory of the Plateau Environmental Damage Control Lanzhou General Hospital of Lanzhou Military Command, PLA Lanzhou China Hypertension Center, FuWai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Peking Union Medical College, Chinese Academy of Medical Sciences, Xicheng District, Beijing, China (J.L., Q.G., Y.D., S.L., J.C.).; Heart Center and Beijing Key Laboratory of Hypertension, Beijing Chaoyang Hospital, Capital Medical University, China (J.L.). Department of Cardiology, Xuanwu Hospital, Capital Medical University NO. 45, Changchun Street, Xicheng, Beijing 100053, China. 1Ivy Brain Tumor Center, Barrow Neurological Institute, Phoenix, Arizona.; 2Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan. MOE Joint International Research Laboratory of Synthetic Biology and Medicine, School of Biology and Biological Engineering, South China University of Technology, Guangzhou 510006, P. R. China School of Computer Science and Technology, Henan Polytechnic University, Jiaozuo 454000, People’s Republic of China (J.L.); and Department of Infectious Diseases & Immunology, University of Florida, Gainesville, FL, USA; Division of Gastroenterology, Hepatology & Nutrition, Department of Medicine, University of Florida, Gainesville, FL, USA Institute of Acupuncture and Moxibustion, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300112, China. CAS Key Laboratory of Receptor Research, the National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China School of Microelectronics, Southern University of Science and Technology, Shenzhen 518055, China Hubei Provincial Center for Disease Control and Prevention, Wuhan, China. College of Life Sciences, Beijing Normal University, Beijing, China; CAS Key Laboratory of Pathogenic Microbiology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China Contribution from the Department of Chemistry and Department of Biochemistry, University of Illinois at Urbana−Champaign, Urbana, Illinois 61801 Department of Immunology, Basic Medical College of Beihua University, Jilin 132013, China Department of Gynecology Tianjin First Central Hospital Tianjin China From the Department of Physiology and Functional Genomics, University of Florida College of Medicine, Gainesville. School of Environmental Science and Engineering, Changzhou University, Changzhou 213164, China; Key Laboratory of Advanced Plasma Catalysis Engineering for China Petrochemical Industry, Changzhou 213164, China TEDA International Cardiovascular Hospital, Tianjin, China Department of Orthodontics Peking University School and Hospital of Stomatology & National Center of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices & Beijing Key Laboratory of Digital Stomatology & Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health Beijing China Tianjin Institute of Environmental and Operational Medicine, Tianjin300050, China; Tianjin University of Traditional Chinese Medicine, Tianjin301617, China Department of Anesthesiology, Honghui Hospital, and the Key Laboratory of Biomedical Information Engineering of Ministry of Education, Institute of Biomedical Engineering, School of Life Science and Technology, Xi’an Jiaotong University, Xi’an, China CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.; Beijing Key Laboratory of Microbial Drug Resistance and Resistome, Beijing, China. Children's Hospital Boston MA USA; Department of Biological Chemistry and Molecular Pharmacology Harvard Medical School Boston MA USA Hoffmann Institute of Advanced Materials, Shenzhen Polytechnic, 7098 Liuxian Blvd, Nanshan District, Shenzhen, 518055, China; Department of Chemistry and Chemical Biology, Rutgers University, 123 Bevier Road, Piscataway, NJ, 08854, USA 2Karmanos Cancer Institute, Wayne State University, Detroit, Michigan. Department of Child and Adolescent Health, School of Public Health, Medical College of Soochow University, Suzhou, Jiangsu, P.R. China College of Chemical Engineering and ‡College of Chemistry, Sichuan University, 29 Wangjiang Road, Chengdu 610064, People’s Republic of China Development Center of Plant Germplasm Resources College of Life Sciences Shanghai Normal University Shanghai 200234 China; Division of Glycoscience Department of Chemistry School of Engineering Sciences in Chemistry Biotechnology and Health KTH Royal Institute of Technology AlbaNova University Centre Stockholm SE106 91 Sweden J. Li, D. Liaw, K. Podsypanina, S. I. Wang, J. Puc, C. Miliaresis, R. Parsons, Department of Pathology and Department of Medicine, College of Physicians & Surgeons, Columbia University, 630 West 168 Street, New York, NY 10032, USA. Department of Orthopaedic Oncology, Xijing Hospital Affiliated to The Fourth Military Medical University, Xi’an, Shaanxi, China (mainland) ELORET Corportaion, ‡SGT, Inc., and §University Space Research Association (USRA), NASA Ames Research Center, Moffett Field, California 94035, United States Department of Neurology, General Hospital of Northern Theater Command Aviation and Nautical Medical Center, Navy General Hospital, No. 6 Fucheng Road, Haidian District, Beijing 100048, P.R. ChinaP.R. China Key Laboratory of Bioresources and Eco‐Environment (Ministry of Education), College of Life Sciences Sichuan University Sichuan Chengdu China Laboratory for Innovative, Chemistry, and Natural Products-Based Interdisciplinary Drug Discovery, Texas A&M University, College Station, TX 77842; and MD Anderson Cancer Center, Department of Radiation Oncology, Houston, Texas Jiangxi Provincial Institution of Traditional Chinese Medicine, Nanchang, China. Tianjin Key Laboratory of Molecular Optoelectronic Department of Chemistry School of Science Tianjin University Tianjin 300072 China Department of Endocrinology and Metabolism, Suqian First Hospital, Suqian, Jiangsu 223800, P.R. China Jing Li is an assistant professor in the Department of Healthcare Policy and Research at Weill Cornell Medical College. State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201620, PR China Glyn O. Phillips Hydrocolloid Research Centre; National “111” Center for Cellular Regulation and Molecular Pharmaceutics; Key Laboratory of Fermentation Engineering (Ministry of Education); Department of Bioengineering and Food Science; Hubei University of Technology Northeast Normal University Key Laboratory of Molecular Epigenetics, Ministry of Education and Institute of Cytology and Genetics, , Changchun 130024 , China Shanghai Center for Plant Stress Biology, Center of Excellence for Molecular Plant Sciences Chinese Academy of Sciences Shanghai China; University of Chinese Academy of Sciences Beijing China School of Materials Science and Engineering, Jiangsu Collaborative Innovation Center of Photovoltaic Science and Engineering, Changzhou University, Changzhou, Jiangsu 213164, China Taizhou Mabtech Pharmaceuticals Co., Ltd. Shanghai China Department of Evidence‐Based Medicine and Clinical Epidemiology West China Hospital Sichuan University Chengdu China Xi'an Key Laboratory of Sustainable Energy Materials Chemistry Xi'an Jiaotong University Xi'an 710049 P. R. China Key Laboratory for Polymeric Composite and Functional Materials of Ministry of Education, Key Laboratory of High Performance Polymer-based Composites of Guangdong Province, School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, China College of Light Industry and Food Engineering, Guangxi University, Nanning 530004, China; Guangxi Key Laboratory of Clean Pulp & Papermaking and Pollution Control, Nanning 530004, China Key Laboratory of Bio-resources and Eco-environment (Ministry of Education), College of Life Sciences, Sichuan University, Chengdu 610064, China 6The First Department of Hepatic Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China. National High Magnetic Field Laboratory, Los Alamos National Laboratory, Los Alamos, New Mexico 87545, United States; Wuhan National High Magnetic Field Center, Huazhong University of Science and Technology, Hubei 430074, China School of Pharmacy Health Science Center Xi'an Jiaotong University Xi'an Shaanxi Province China State Key Laboratory of Food Nutrition and Safety, Tianjin University of Science and Technology (TUST), Tianjin 300457, China Department of Acupuncture and Moxibustion, The Second Hospital of Shijiazhuang, Shijiazhuang 050051, Hebei Province, China. Department of Second Cardiology Affiliated Hospital of Hebei University Baoding Hebei People's Republic of China State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China Department of Pediatrics, University of Chicago, Chicago, Illinois 60637-1470 School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, 510006, China; Center for Cellular & Structural Biology, Sun Yat-Sen University, Guangzhou, 510006, China Center for Applied Chemical Research, Frontier Institute of Science and Technology and State Key Laboratory for Mechanical Behavior of Materials, Xi’an Jiaotong University, Xi’an 710049, China Hefei National Research Center for Physical Sciences at the Microscale, Department of Materials Science & Engineering, CAS Key Laboratory of Materials for Energy Conversion, University of Science and Technology of China, 230026 Hefei, Anhui, China Department of Cardiovascular, Xuanwu Hospital, Beijing 100053, China. Department of Nephrology, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, P.R. China Departments of Transplantation and Gastroenterology, Tianjin Medical University, Tianjin 300070, P.R. China Department of Clinical Laboratory The Affiliated Hospital of Qingdao University Qingdao China Department of Pulmonary Medicine, Peking University People's Hospital, Beijing, China Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, Beijing 100081, China State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences; Changchun; P. R. China Joint National Laboratory for Antibody Drug Engineering, Key Laboratory of Cell and Molecular Immunology, School of Medical Sciences, Henan University, Kaifeng 475004, P.R. China. School of Mechanical and Aerospace Engineering Jilin University Changchun China State Key Laboratory of Materials-Oriented Chemical Engineering, College of Chemistry and Chemical Engineering, Nanjing Tech University, Nanjing 210009, P. R. China Department of Pediatric Intensive Care Unit, Critical Care Medicine Center, Women and Children’s Hospital, Qingdao University, Qingdao, Shandong, China Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Key Laboratory of Pesticide Chemistry and Application, Ministry of Agriculture, Beijing 100193, China Merck & Co., Inc., Whitehouse Station NJ USA Joint Key Laboratory of the Ministry of Education Institute of Applied Physics and Materials Engineering (IAPME) University of Macau Macau SAR China Department of Medical Oncology, First Affiliated Hospital of Medical College of Shihezi University, Shihezi, Xinjiang Uygur Autonomous Region 832000, China From the Terrence Donnelly Heart Centre (A.W.B., N.N., A.C., R.R., M.K.N., J.L., M.R.E., J.S., B.H.S.), Division of Cardiology, St. Michael’s Hospital; the Division of Cardiovascular Research, Research Institute (S.O., M.R.), The Hospital for Sick Children; Division of Cardiology, Mount Sinai Hospital (A.W.B.), and the Departments of Medicine, Pediatrics and Pathology, University of Toronto, Toronto, Canada. Department of Physiology and Pathophysiology, Peking University Health Science Center, Beijing 100083, China, and Key Laboratory of Molecular Cardiovascular Science, Peking University Health Science Center, Beijing 100083, China Hebei Normal University, China State Key Laboratory of Plant Physiology and Biochemistry, College of Life Science, Zhejiang University, Hangzhou 310029, China Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, Illinois 60637, United States Department of Radiology Peking Union Medical College Hospital Peking Union Medical College & Chinese Academy of Medical Sciences Beijing China 1Department of Pharmacology and Pharmaceutical Sciences, School of Medicine, Tsinghua University, Beijing, China. Department of Gastroenterology General Hospital of Shenyang Military Area Shenyang China; Postgraduate College Dalian Medical University Dalian China Department of Rheumatology and Clinical Immunology, Chinese Academy of Medical Sciences & Peking Union Medical College, National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Ministry of Science & Technology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital (PUMCH), Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, People’s Republic of China School of Science, Yanshan University, Qinhuangdao, Hebei 066004, P.R.China. Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, College of Life Sciences, Nankai University, Tianjin, China Center for Reproductive Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China. College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou 450001, P. R. China Department of Rheumatology and Immunology People's Hospital Peking University Medical School Beijing China Department of Anesthesiology,the Red Cross HospitalAffiliated to Medical College of Xi'an Jiaotong University,Xi'an 710054,China. College of Science, Yanshan University, Qinhuangdao 066004, China. School of Chemical Engineering Northwest University 710069, Xi'an Shaanxi China College of Forestry, Shanxi Agricultural University, Jinzhong 030801, Shanxi, China. School of Traditional Chinese Medicine, Capital Medical University, Beijing 100069, China; Beijing Key Laboratory of Traditional Chinese Medicine Collateral Disease Theory Research, Beijing 100069, China Department of Burns and Plastic Surgery, Tangdu Hospital, The Fourth Military Medical University Xi'an, China. University of Vienna Institute of Organic Chemistry Währinger Strasse 38 1090 Vienna Austria Center for Drug Delivery and Nanomedicine Department of Pharmaceutical Sciences University of Nebraska Medical Center Omaha NE 68198 USA Central Laboratory, Shanghai 10th People's Hospital of Tongji University 200072, P. R. China ; Department of Medical Laboratory, Shanghai 10th People's Hospital of Tongji University Shanghai 200072, P. R. China. Department of Stomatology, Affiliated Longhua People's Hospital, Southern Medical University, Shenzhen, Guangdong 518000, P.R. China Department of Stomatology Children's Hospital of Nanjing Medical University Nanjing PR China Department of Food and Nutrition, Hallym University, Chuncheon, Kangwon-do, 200-702 Korea CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China. Department of Prosthodontics, College of Stomatology, China Medical University, Shenyang 110002, Liaoning Province, China. Department of Endocrinology and Metabolism The Second Affiliated Hospital of Dalian Medical University Dalian China School of Material Science and Chemistry Southwest University of Science and Technology Mianyang 621010 P. R. China 1 Department of Computer Science and Engineering, University of California, Riverside, CA 92521, USA, 2College of Physics and Information Science, Hunan Normal University, Changsha 410081, P. R. China and 3Department of Electrical Engineering and Computer Science, Case Western Reserve University, Cleveland, OH 44106, USA Center on Nanoenergy Research, School of Physical Science and Technology, Guangxi University, Nanning, Guangxi 530004, P. R. China State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan Province, China Department of Social Medicine and Health Management, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, China; University of Science and Technology of China, Hefei, Anhui 230026, China Department of Otolaryngology Head and Neck Surgery,Children's Hospital Affiliated of Zhengzhou University,Henan Children's Hospital,Zhengzhou Children's Hospital,Zhengzhou,450000,China. Key Laboratory of All Optical Network and Advanced Telecommunication Network, Ministry of Education, Institute of Lightwave Technology, Beijing Jiaotong University, Beijing 100044, China Center of Excellence in Tissue Engineering, Institute of Basic Medical Sciences and School of Basic Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing Key Laboratory of New Drug Development and Clinical Trial of Stem Cell Therapy, Beijing 100005, China Department of Evidence‐Based Medicine and Clinical Epidemiology West China Hospital, Sichuan University Chengdu City Sichuan Province China; The Chinese Cochrane Center Chengdu City Sichuan Province China State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian, 350002, P.R. China, and Department of Chemistry and Chemical Biology, Rutgers University, 610 Taylor Road, Piscataway, New Jersey 08854 Fujian Provincial Key Laboratory of Environmental Factors and Cancer Key Laboratory of Preclinical Study for New Drugs of Gansu Province School of Basic Medical Sciences Lanzhou University Lanzhou China Henan Eye Institute and Henan Eye Hospital, Zhengzhou, Henan, China Children’s Health Department, Hubei Maternal and Child Health Hospital, Wuhan, China State Key Laboratory of Reproductive Medicine; Nanjing Medical University; Nanjing, China Key Laboratory of Photochemical Conversion and Optoelectronic Materials Technical Institute of Physics and Chemistry Chinese Academy of Sciences Beijing 100190 China 1Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, China.; 2Department of Pancreatic Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China. School of Life Science and Technology, ShanghaiTech University, 393 Middle Hua Xia Road, Shanghai 201210, China School of Medicine, Hangzhou Normal University, Hangzhou 311121, China Key Laboratory of Biomass Chemical Engineering of Ministry of Education College of Chemical and Biological Engineering Zhejiang University Hangzhou 310027 P. R. China; Institute of Zhejiang University-Quzhou Quzhou 32400 P. R. China Department of Food Science and Technology, College of Light Industry and Food Engineering, Nanjing Forestry University, Nanjing 210037, China Shanxi Province Tissue Bank of China Institute for Radiation Protection, Shanxi Osteorad Biomaterial Co.Ltd, Taiyuan Shanxi, 030006, P.R.China. College of Life Sciences, Anhui Normal University, Wuhu, Anhui 241000, China Department of Geriatrics Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Diseases Beijing China Department School of Chemistry and Chemical Engineering Chongqing University Chongqing 401331 China Department of Women and Children's Medical Center, Gansu Provincial Maternity and Child Care Hospital, Lanzhou, Gansu 730050, P.R. China Department of Pharmacology, School of Pharmacy, Qingdao University Medical College, Qingdao, Shandong, China. Department of Cardiology, Tianjin Nankai Hospital, Tianjin, 300000, China Department of Psychiatry, Hubei Provincial Hospital of Traditional Chinese Medicine, Wuhan 430061, China; Department of Psychiatry, Hubei Institute of Traditional Chinese Medicine, Wuhan 430074, China; The Affiliated Hospital of Hubei University of Chinese Medicine, Wuhan 430061, China Chemical Pollution Control Chongqing Applied Technology Extension Center of Higher Vocational Colleges, School of Chemical and Pharmaceutical Engineering, Chongqing Industry Polytechnic College, Chongqing, 401120, P. R. China State Key Laboratory of Electroanalytical Chemistry; Changchun Institute of Applied Chemistry; Chinese Academy of Sciences; Changchun; China Fisheries Research Institute Anhui Academy of Agricultural Sciences Hefei China Department of Anatomy School of Medicine, Zhejiang University Hangzhou China Department of Breast Surgery, Fujian Medical University Union Hospital, Fuzhou, Fujian, Fujian Province, China; Department of General Surgery, Fujian Medical University Union Hospital, Fuzhou, Fujian, Fujian Province, China; Breast Cancer Institute, Fujian Medical University, Fuzhou, Fujian, Fujian Province, China Department of Infectious Diseases and Hepatology, The Second Hospital of Shandong University, Jinan, China Department of Ultrasound, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing 100037. Leejingabc@sina.com The Second Affiliated Hospital, Kunming Medical University, China Department of Medical Research, Shanghai MajorMed Diagnostics Company, Shanghai 201321, P.R. China Key Laboratory of Agro-Ecological Processes in Subtropical Region, Hunan Provincial Key Laboratory of Animal Nutritional Physiology and Metabolic Process, Hunan Research Center of Livestock and Poultry Sciences, South Central Experimental Station of Animal Nutrition and Feed Science in the Ministry of Agriculture, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha 410125, China; Department of Animal Science, Hunan Agriculture University, Changsha 410125, China Department of Bioinformatics, Key Laboratory of Ministry of Education for Gastrointestinal Cancer, Fujian Medical University, Fuzhou, China 1Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit, Michigan. The University of Texas MD Anderson Cancer Center, Houston, Texas School of Materials and Chemical Engineering, Xuzhou University of Technology, Xuzhou 221018, China Department of Surgery, The Second Military Medical University, Shanghai 200433, China State Key Laboratory of Coordinate Chemistry, Nanjing National Laboratory of Microstructures, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, People’s Republic of China Department of Clinical Laboratory, Capital Institute of Pediatrics, Beijing, China State Key Laboratory of Electroanalytical Chemistry; Changchun Institute of Applied Chemistry; Chinese Academy of Sciences; Changchun; PR China Center for Applied Chemical Research; Frontier Institute of Science and Technology; Xi'an Jiaotong University; Xi'an, China Department of Pediatrics, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, Liaoning, China State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, China Department of PharmacologyBasic Medical School of Wuhan UniversityWuhanChina Key Laboratory of Structure-Based Drug Design and Discovery, Shenyang Pharmaceutical University, Shenyang 110016, P. R. China Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, United States Radiology State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, College of Life Sciences, South China Agricultural University, Guangzhou, China Department of Pulmonary and Critical Care Medicine, Huashan Hospital Fudan University Shanghai China Echocardiography Medical Center Capital Medical University Affiliated Beijing Anzhen Hospital Beijing China Clinical Pharmacology and Quantitative Pharmacology, Clinical Pharmacology & Safety Sciences (CPSS), R&D, AstraZeneca South San Francisco California USA Department of Traditional Chinese Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan 430022, China Department of Allergy and Clinical Immunology State Key Laboratory of Respiratory Disease The First Affiliated Hospital of Guangzhou Medical University Guangzhou China Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Heart Failure Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China Key Laboratory of Computational Physical Sciences (Ministry of Education), State Key Laboratory of Surface Physics and Department of Physics, Fudan University, Shanghai 200433, People’s Republic of China; Collaborative Innovation Center of Advanced Microstructures, Nanjing 210093, People’s Republic of China Department of Pharmaceutics, Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, PR China Jiangxi College of Applied Technology; Ganzhou 341000; China; Engineering Research Center of Nano-Geo Materials of Ministry of Education; P. R. China University of Geosciences Nursing Department Second Hospital of Hebei Medical University Shijiazhuang China State Key Lab of Food Science and Technology, Institute for Advanced Study University of Nanchang 235, Nanjing East Road Nanchang Jiangxi 330047 People's Republic of China; Guelph Food Research Center Agriculture and Agri‐Food Canada Guelph ON N1G 5C9 Canada College of Biological Science and Agriculture, Qiannan Normal University for Nationalities, Duyun 558000, China Key Laboratory of Luminescence Analysis and Molecular Sensing, Ministry of Education (Southwest University), College of Pharmaceutical Sciences, Southwest University, Chongqing, China. Institute of Organic Chemistry, University of Vienna Währinger Strasse 38 1090 Vienna Austria Clinical Biobank Center, Microbiome Medicine Center, Department of Laboratory Medicine, Zhujiang Hospital Southern Medical University Guangzhou China; Neurosurgery Center, The National Key Clinical Specialty, The Engineering Technology Research Center of Education Ministry of China on Diagnosis and Treatment of Cerebrovascular Disease, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, The Neurosurgery Institute of Guangdong Province, Zhujiang Hospital Southern Medical University Guangzhou China Key Laboratory of Organic Chemistry, Institute of Organic Chemistry, Jiangxi Science & Technology Normal University, Nanchang 330013, Jiangxi Province, China Chongqing Academy of Animal Science Chongqing China Department of Surgery, School of Medicine, University of Virginia, Charlottesville, VA, USA Beijing Novartis Pharma Beijing China Photosynthesis Research Center, Key Laboratory of Photobiology, Institute of Botany, Chinese Academy of Sciences, Beijing 100093, China Department of Pharmacology; College of Basic Medical Sciences; Jilin University; Changchun; P. R. China Guangdong Provincial Key Laboratory of Cancer Immunotherapy Research and Guangzhou Key Laboratory of Tumor Immunology Research, Cancer Research Institute, Southern Medical University, Guangzhou 510515, China Institute for Advanced Studies (IAS); Wuhan University; Wuhan; P. R. China Echocardiography and Vascular Ultrasound Center The First Affiliated Hospital College of Medicine Zhejiang University Hangzhou China College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China School of Chemistry, Chemical Engineering and Life Sciences Wuhan University of Technology Wuhan China Department of Molecular, Cellular and Developmental Biology Centre of Excellence for Plant Metabolomics and Australian Research Council Centre of Excellence in Plant Energy Biology, University of Western Australia, Crawley WA 6009, Australia Department of Hematology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region 530021, P.R. China State Key Lab of Crystal Materials; Shandong University; Jinan 250100; China Emergency Department of Harrison International Peace Hospital Affiliated to Hebei Medical University, China State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, Jilin, China and Graduate School of the Chinese Academy of Sciences, Beijing, 100039, P. R. China State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Changchun, Jilin 130022 (P. R. China) Division of Vascular Surgery, University of Minnesota Medical Center, USA College of Plant Protection, Hebei Agricultural University, Baoding, PR China State Key Laboratory of Grassland Agro‐ecosystems, Key Laboratory of Grassland Livestock Industry Innovation, Ministry of Agriculture and Rural Affairs, Engineering Research Center of Grassland Industry, Ministry of Education, College of Pastoral Agriculture Science and Technology Lanzhou University Lanzhou 730020 P. R. China Second Clinical Medical College Shanxi Medical University Taiyuan Shanxi China Department of Osteonecrosis of The Femoral Head, Luoyang Orthopedic Hospital of Henan Province, Luoyang, Henan 471000, P.R. China From the State Key Laboratory of Pharmaceutical Biotechnology, Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, China (J.Z., L.L., J.L., C.-Y.Z., Y.Z., K.Z.); and Department of Biology, Center for Inflammation, Immunity and Infection, Georgia State University, Atlanta (Y.L.). Department of Plastic and Burn Surgery, The Second Affiliated Hospital, Air Force Medical University, Xi'an, Shaanxi 710038, P.R. China Authors' Affiliations: 1Department of Biochemistry and Molecular Genetics; 2Center of Molecular Biology of Oral Diseases College of Dentistry, Cancer Center; and 3Department of Medicine, University of Illinois at Chicago, Chicago, Illinois Department of Psychology, Lancaster University, Lancaster, United Kingdom School of Public Health, Lanzhou University State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Sun Yat-sen University, Guangzhou, China Third-grade Pharmacological Laboratory on Traditional Chinese Medicine, State Administration of Traditional Chinese Medicine, China Three Gorges University, Yichang 443002, China; College of Basic Medical Science, China Three Gorges University, Yichang 443002, China Department of Pediatrics, University of Chicago, Chicago, Illinois 60637; and State Key Laboratory of Marine Pollution (SKLMP), City University of Hong Kong, Kowloon Tong, Hong Kong SAR, China; Department of Chemistry, City University of Hong Kong, Kowloon Tong, Hong Kong SAR 999077, China; Research Centre for the Oceans and Human Health, City University of Hong Kong Shenzhen Research Institute, Shenzhen, Guangdong 518000, China State Key Laboratory of Pollution Control and Resources Reuse, College of Environmental Science and Engineering Tongji University Shanghai China College of Marine Life Sciences, Ocean University of China, Qingdao, Shandong, 266003, China School of Chemistry and Chemical Engineering, Yancheng Institute of Technology, Yancheng 224051, People’s Republic of China College of Pharmacy Shandong University of Traditional Chinese Medicine Jinan P. R. China State Key Laboratory of Food Science and Technology, Institute for Advanced Study, Nanchang University, Nanchang, Jiangxi 330047, P.R. China School of Chemistry and Chemical Engineering, Xi'an University, Xi'an, China School of Chemistry and Chemical Engineering; Shandong University; Jinan 250100; China; School of Environmental Science and Engineering Departments of Medicine and Pediatrics Medical College of Virginia/Virginia Commonwealth University Richmond Virginia 23298 State Key Laboratory of Respiratory Diseases National Clinical Research Center for Respiratory Diseases Guangzhou Institute of Respiratory Health the First Affiliated Hospital of Guangzhou Medical University Guangzhou China State Key Laboratory of Organ Failure Research Guangdong Provincial Key Laboratory of Gastroenterology Department of Gastroenterology Nanfang Hospital Southern Medical University Guangzhou Guangdong China Protein Metrics LLC., Cupertino, California 95014, United States College of Chemical Engineering and ‡College of Chemistry, Sichuan University, 29 Wangjiang Road, Chengdu, Sichuan 610064, PR China Department of Epidemiology , , Suzhou, Jiangsu , China; School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases of Soochow University , , Suzhou, Jiangsu , China Department of Electrocardiogram Room, Yantai Yuhuangding Hospital Affiliated To Qingdao University, Yantai 264000, Shandong, China Guangdong Provincial Key Laboratory of Liver Disease Research, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, China (J.F., Y.Lu., H.X., J.Hua., M.W., W.W., D.Z., G.S., C.R., J.Lia., L.F., Y.Li.); Key Laboratory of Green Chemistry & Technology of Ministry of Education; College of Chemistry; Sichuan University; Chengdu 610064; P. R. China Management Department, Hainan Branch of Chinese PLA General Hospital, Sanya, China The State Key Laboratory Breeding Base for Sustainable Control of Pest and Disease, Key Laboratory of Biotechnology in Plant Protection of MOA of China and Zhejiang Province, Institute of Virology and Biotechnology Zhejiang Academy of Agricultural Sciences Hangzhou 310021 China Cell Signaling Technology, Danvers, MA, USA Department of traditional Chinese medicine, Children' Hospital of Kaifeng, Kaifeng, Henan province, 4750000, China. Chongqing Key Laboratory of Neurodegenerative Diseases, Chongqing, China; Department of Neurology, Chongqing General Hospital, University of Chinese Academy of Sciences, Chongqing, China Electrical Engineering and Computer Science Department, Case Western Reserve University 1 1 Cleveland, OH 44106, USA Patricia M. LoRusso, Karen M. Forman, MaryJo Pilat, Jing Li, Elisabeth I. Heath, and Lisa M. Malburg, Karmanos Cancer Institute, Wayne State University, Detroit, MI; Martin J. Edelman, Mary F. Quinn, and Edward A. Sausville, Marlene and Stewart Greenebaum Cancer Center, University of Maryland, Baltimore, MD; and Susan L. Bever, Patrick J. Klein, Christopher P. Leamon, and Richard A. Messmann, Endocyte, West Lafayette, IN. Department of Radiology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China Department of Infection Control, The Renmin Hospital of Yan’an City, Yan’an, People’s Republic of China Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Peking Union Medical College Hospital, Beijing Key Laboratory of New Drug Development and Clinical Trial of Stem Cell Therapy, Beijing 100005, China State Key Laboratory of Urban and Regional Ecology, Research Centre for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China. lijing_cadx@163.com Jiangsu Institute of Haematology The First Affiliated Hospital of Soochow University Suzhou Jiangsu China State Key Laboratory of Crop Stress Biology for Arid Areas and, College of Life Sciences, Northwest A & F University, Yangling, Shaanxi 712100, China Hepatobiliary Institute, Southwestern Hospital; No 30. Gaotanyan, ShapingBa Distract Chongqing 400038 China School of Environment, Tsinghua University, Beijing 100084, China Radiology Department, Southwest Hospital, Third Military Medical University, Chongqing 400037, China Clinical Laboratory, First Affiliated Hospital of Bengbu Medical College, Bengbu 233004, China. Eternity Bioscience Inc., 6 Cedarbrook Drive, Cranbury, New Jersey 08512, United States State Key Laboratory of Applied Organic Chemistry (SKLAOC), College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, P.R. China; School of Chemistry and ARC Centre of Excellence for Electromaterials Science, Monash University, Clayton, Victoria 3800, Australia Department of Rheumatology, Cangzhou Central Hospital, Cangzhou, Hebei, China School of Foreign Languages; Zhongyuan University of Technology; Zhengzhou 450007; P.R. China Pu’er Public Security Bureau, Pu’er, China School of Life Science, University of Science and Technology of China, Hefei 230026, Anhui province, People's Republic of China; National Institute for the Control of Pharmaceutical and Biological Products, Beijing 100050, People's Republic of China State Key Lab of Food Science & Technology, Nanchang University, Nanchang, Jiangxi 330047, China CAS Key Laboratory of Bio‐Inspired Materials and Interfacial Sciences Technical Institute of Physics and Chemistry Chinese Academy of Sciences Beijing 100190 China Department of Pediatrics, Second Hospital of Xi'an Jiaotong University School of Medicine, Xi'an 710004, China. lijing12788@163.com College of Electronic Information & Key Lab of Information Materials of Sichuan Province; Southwest University for Nationalities; Chengdu 610041; China School of Marine Science and Engineering, Hainan Provincial Key Lab of Fine Chemistry, School of Chemical Engineering and Technology, Hainan University, Haikou 570228, China National Clinical Research Center of Cardiovascular Diseases State Key Laboratory of Cardiovascular Disease Chinese Academy of Medical Sciences and Peking Union Medical College Fuwai Hospital, National Center for Cardiovascular Diseases Beijing People's Republic of China Moku Laboratory, Alibaba Group, Beijing, China School of Chemical Engineering, Sichuan University, Chengdu 610065, China Department of Economic Plants and Biotechnology, Yunnan Key Laboratory for Wild Plant Resources, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China a School of Pharmaceutical Sciences, Central South University , Changsha , 410013 , China Department of Acupuncture and Moxibustion, the First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China. Departments ofNeurological Surgery, State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences Changchun, Jilin, 130022, People’s Republic of China; Graduate School of the Chinese Academy of Sciences, Beijing, 100039, People’s Republic of China Key Laboratory of Pathobiology, Department of Pharmacology, Ministry of Education, College of Basic Medicine, Jilin University, Changchun, Jilin 130021, China Key Laboratory of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu 6110031, China Division of Pharmaceutical Sciences of the School of Pharmacy and Department of Biomedical Engineering of the College of Engineering, University of WisconsinMadison, Madison, Wisconsin 53705 College of Electrical &Information Engineering & Key Lab of Information Materials of Sichuan Province; Southwest University for Nationalities; Chengdu 610041; China State Key Laboratory of Natural Medicines and Department of Pharmaceutics; China Pharmaceutical University; Nanjing; China Department of Anesthesiology, The First Affiliated Hospital of Jinan University, Guangzhou, China. Department of Gastroenterology Beijing Friendship Hospital Capital Medical University National Clinical Research Center for Digestive Disease Beijing Digestive Disease Center Beijing Key Laboratory for Precancerous Lesion of Digestive Disease Beijing 100050 China Jiangsu Key Laboratory of Immunity and Metabolism, Department of Pathogenic Biology and Immunology, Xuzhou Medical University, No. 209 Tongshan Road, Xuzhou, 221004, People's Republic of China Authors' Affiliations: 1Department of Biochemistry and Molecular Genetics, 2Center for Molecular Biology of Oral Diseases, University of Illinois at Chicago; 3Jesse Brown VA Medical Center, Chicago, Illinois; 4Department of Haematology, Cambridge Institute for Medical Research, Cambridge, United Kingdom; and 5Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, Pennsylvania Proteomic Platform and National Key Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China; Department of Biology, Graduate University of the Chinese Academy of Sciences, Beijing 100049, China Columbia University, New York, NY, USA Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Key Laboratory of Integrated Pest Management in Crops, Ministry of Agriculture, Beijing 100193, People's Republic of China Neurology Department, People’s Liberation Army 263 Hospital, 141 Yongshun South Street, Tongzhou District, Beijing 101149, China Postgraduate Student Spoon‐billed Sandpiper (Shanghai) Environment Protection Technology Co. Ltd Shanghai China Division of Anatomical Pathology, Department of Pathology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia School of Materials and Metallurgy, University of Science and Technology Liaoning, Anshan 114051, Liaoning, China Antibiotics Research and Re‐evaluation Key Laboratory of Sichuan Province Sichuan Industrial Institute of Antibiotics, Chengdu University Chengdu Sichuan China Department of Nuclear Medicine, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China Department of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, Guangzhou, 510000, Guangdong, People’s Republic of China Medimmune, Mountain View, CA; Multidisciplinary Cardiovascular Research Centre, Faculty of Medicine and Health, University of Leeds, LS2 9JT Leeds, UK.; School of Medicine, Faculty of Medicine and Health, University of Leeds, LS2 9JT Leeds, UK. Harbin Medical University and Wenzhou Medical University College of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, China; Key Laboratory of Environment Correlative Dietology, Huazhong Agricultural University, Ministry of Education, Wuhan 430070, China NHC Key Laboratory of Clinical Research for Cardiovascular Medications National Clinical Research Center of Cardiovascular Diseases State Key Laboratory of Cardiovascular Disease Fuwai Hospital Chinese Academy of Medical Sciences and Peking Union Medical College National Center for Cardiovascular Diseases Beijing China Department of Hepatobiliary Surgery, Xinqiao Hospital of Third Military Medical University, Chongqing, 400037, China Northwest Institute of Eco-Environment and Resources, Chinese Academy of Sciences, Lanzhou 730000, China; Key Laboratory of Petroleum Resources, Gansu Province, Lanzhou 730000, China Institute of Ecological Planning and Landscape Design, Zhejiang University, Hangzhou 310058, China. Department of Pathology, Zibo Central Hospital, Zibo, Shandong Province, China. Department of Otolaryngology and Head and Neck Surgery, Affiliated Hangzhou First People’s Hospital, Zhejiang University School of Medicine, Hangzhou, China Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials; Ministry-of-Education Key Laboratory for the Green Preparation and Application of Functional Materials; Hubei Key Laboratory of Polymer Materials; School of Materials Science and Engineering; Hubei University Laboratory of Electron Microscopy North Sichuan Medical College Nanchong Sichuan Province China State Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, P. R. China; Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Weijin Road 94, Nankai District, Tianjin 300071, P. R. China Key Laboratory of Biomass Chemical Engineering of Ministry of Education, College of Chemical and Biological Engineering, Zhejiang University, 866 Yuhangtang Road, Hangzhou 310058, P. R. China; Institute of Zhejiang University-Quzhou, 99 Zheda Road, Quzhou 324000, P. R. China Sinovac Biotech Co, Ltd, Beijing, China Department of Chemistry, Wayne State University, Detroit, Michigan 48202, United States Center for Translational Medicine The First Affiliated Hospital of Xi’an Jiaotong University Xi’an People's Republic of China Department of Pharmacy, Gansu Gem Flower Hospital, Xigu District School of Public Health and Family Medicine, Capital Medical University, Beijing, China. Department of Pharmaceutical Sciences Physics and Statistics University of the Sciences in Philadelphia Philadelphia Pennsylvania USA State Key Laboratory of Natural Medicines, Department of Pharmaceutics, China Pharmaceutical University, Nanjing 210009, China Law School Kunming University of Science and Technology Kunming China Department of Ultrasonic medicine; The 1st Affiliated Hospital of Heilongjiang University of Chinese Medicine; Harbin; China Department of Pathology and Center of Electron Microscope, School of Basic Medicine, Harbin Medical University, Harbin, China State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, PR China Department of Clinical Laboratory First Affiliated Hospital of Bengbu Medical College Bengbu China Department of Biological Sciences and Biotechnology, State Key Laboratory of Biomembrane and Membrane Biotechnology, Tsinghua University, Beijing 100084, P. R. China Anorectal Department, The Central Hospital of Enshi Tujia and Miao Autonomous Prefecture, Enshi, P.R. China Authors' Affiliations: 1Molecular Oncology Laboratory, and Departments of 2Comprehensive Treatment and 3Radio-intervention Therapy, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, PR China Department of Endocrinology and Metabolism, Huai’an Hospital Affiliated to Xuzhou Medical University and Huai’an Second People’s Hospital, Huai’an, China Department of Materials Science and Engineering, Southern University of Science and Technology, 1088 Xueyuan Boulevard, Nanshan District, Shenzhen, Guangdong 518055, P. R. China Laboratory of Molecular Recognition and Synthesis, Department of Chemistry, Zhejiang University, Hangzhou 310027, Zhejiang, People's Republic of China, and State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, People's Republic of China Department of Obstetrics and Gynecology Beijing Tian Tan Hospital Jiaxing Maternity and Child Health Care Hospital, Jiaxing, China The First Clinical Medical College of Guangzhou University of Chinese Medicine, Guangzhou 510000, China; Lingnan Medical Research Center of Guangzhou University of Chinese Medicine, Guangzhou 510000, China Email: 472522080@qq.com. Department of Internal Medicine, 958 Hospital of People’s Liberation Army, Chongqing, China State Key Laboratory of Oral Diseases National Clinical Research Center for Oral Diseases Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management West China Hospital of Stomatology Sichuan University Chengdu China School of Civil Engineering, Inner Mongolia University of Technology, Hohhot 010051, China Department of Neurology, The First Affiliated Hospital of Anhui University of Science and Technology (The First People’s Hospital of Huainan City), Huainan, P.R. China Department of Internal Medicine Center for Health Services Research University of Kentucky Lexington Kentucky Radiation Oncology, Department of Electrical Engineering and Computer Science, Case Western Reserve University, Cleveland, OH 44106, USA Jinzhou Medical University, Jinzhou 121001, China Department of Epidemiology, School of Public Health, Shandong University, Jinan 250012, Shandong, China; State Key Laboratory of Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China; Shandong University Climate Change and Health Center, Jinan 250012, Shandong, China. Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA 92093-0687; Department of Ophthalmology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, 1665 Kongjiang Road, Shanghai 200092, China Department of Cancer Epidemiology, Cancer Institute & Hospital, CAMS and PUMC, Beijing,China. Orthopaedic Center, The First Affiliated Hospital of Shihezi University Medical College, Shihezi, Xinjiang 832008, China Huzhou Key Laboratory of Molecular Medicine, Huzhou Cent Hospital, Affiliated Cent Hospital HuZhou University, Huzhou, Zhejiang 313000, China School of Materials Science and Chemical Engineering, Ningbo University, Ningbo, 315211, China Tianjin Eye Hospital, Tianjin Key Laboratory of Ophthalmology and Vision Science, Clinical College of Ophthalmology, Tianjin Medical University, Tianjin, China Department of Infectious Diseases Xi'an Children's Hospital Xi'an Shaanxi China Key Laboratory of Animal Disease and Public Health, Henan University of Science and Technology, and Key Laboratory of Live Carrier Biomaterial and Animal Disease Prevention and Control, Luoyang 471003, China. Department of Orthopedic Surgery West China Hospital Sichuan University 610041 Chengdu China Key Laboratory of Resource Biology and Biotechnology in Western China (Northwest University), Ministry of Education, Xi’an, Shaanxi 710069, China; School of Life Sciences, Northwest University, Xi’an, Shaanxi 710069, China Institute of Organic Chemistry University of Vienna Währinger Strassee 38 1090 Vienna Austria Department of Pathology, Zibo Central Hospital, Zibo 255000, Shandong, China College of Chemistry, Sichuan University, Chengdu 610064, P. R. China Department of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Affiliated Hospital of China Medical University, No. 155 Nanjing Bei Street, Heping District, Shenyang, Liaoning 110001, China Shanghai Frontiers Science Center of Biomimetic Catalysis, Joint Laboratory of International Cooperation of Resource Chemistry of Ministry of Education, Shanghai Normal University, Shanghai 200234, China College of Marine Life Sciences, Ocean University of China, Qingdao, Shandong, 266003, PR China College of Marine Life Science; Ocean University of China; Qingdao; P.R. China Electrocardiogram Room, Yantai Yuhuangding Hospital Affiliated to Qingdao University, Yantai, China. Department of Internal Medicine‐Cardiovascular Wuhan No. 1 Hospital Wuhan Hubei People's Republic of China State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, PR China Department of Vascular anomalies and Interventional Radiology, Children’s Hospital Affiliated to Shandong University, Jinan, China Pacific Northwest National Laboratory, Richland, Washington 99352 State Key Laboratory of Natural Medicines, School of Pharmacy, China Pharmaceutical University, Nanjing, China Department of BiochemistryAlbert Einstein College of Medicine Bronx New York 10461 USA Center for Functional Nanomaterials, Brookhaven National Laboratory, Upton, New York, New York 11973, United States State Key Laboratory of Oral Disease, Sichuan University, Chengdu 610041, China; Email: lijing19840108@126.com. Department of Cell Biology, and Beijing National Laboratory for Molecular Sciences, Organic Solids Laboratory, Institute of Chemistry, Beijing 100190, China; Graduate School of Chinese Academy of Sciences, Beijing 100049, China Division of Nephrology Guangdong General Hospital, Guangdong Academy of Medical Sciences Guangzhou China Faculty of Nursing, Tianjin Medical CollegeTianjin, China. School of Basic Medical Sciences, School of Pharmacy and State Key Laboratory of Functions and Applications of Medicinal Plants Guizhou Medical University Guizhou China; National Engineering Research Center of Miao’s Medicines and Engineering Research Center for the Development and Application of Ethnic Medicine and TCM Ministry of Education and Guizhou Provincial Key Laboratory of Pharmaceutics Guiyang Guizhou China The First School of Clinical Medicine Guangxi University of Chinese Medicine Nanning Guangxi China Key Laboratory of Pathogenic Microbiology and Immunology Institute of Microbiology Chinese Academy of Sciences Beijing China State Key Laboratory of Anti‐Infective Drug Development Sunshine Lake Pharma Co., Ltd. Dong Guan China Laboratory of Pathogen Biology, School of Basic Medicine and Forensics, Hangzhou Medical College , Hangzhou, China; School of Basic Medicine and Forensics, Hangzhou Medical College , Hangzhou, China; Engineering Research Center of Novel Vaccine of Zhejiang Province, Hangzhou Medical College , Hangzhou, China Department of Laboratory Medicine, Shanghai Tongji Hospital, Tongji University School of Medicine, Shanghai 200065, China CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China Authors' Affiliations: 1Barbara Ann Karmanos Cancer Institute, Departments of Medicine and Pharmacology, Wayne State University; 2Biostatistics Unit, Barbara Ann Karmanos Cancer Institute, Detroit, Michigan; 3Marlene and Stewart Greenebaum Cancer Center, University of Maryland, Baltimore, Maryland; 4Departments of Medicine and Pharmacology Cancer Institute, University of Pittsburgh, Pittsburgh, Pennsylvania; 5National Cancer Institute Cancer Therapy Evaluation Program Branch, Bethesda, Maryland; and 6Royal Marsden Hospital, London, United Kingdom Department of Prosthodontics Hospital of Stomatology, Jilin University Changchun China Ministry of Education Key Laboratory for Analytical Science of Food Safety and Biology, Fujian Provincial Key Laboratory of Analysis and Detection for Food Safety, College of Chemistry, Fuzhou University, Fuzhou 350116, Fujian, China College of Food Science and Technology, Huazhong Agricultural University, Wuhan, China; Key Laboratory of Environment Correlative Dietology (Huazhong Agricultural University), Ministry of Education, Wuhan, China Clinical Laboratory of BGI Health BGI‐Wuhan Wuhan China Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, Kunming, Yunnan 650500, China State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, P.R. China Nanjing Drum Tower Hospital Center of Molecular Diagnostic and Therapy Chinese Academy of Medical Sciences Research Unit of Extracellular RNA State Key Laboratory of Pharmaceutical Biotechnology Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology NJU Advanced Institute of Life Sciences (NAILS) Institute of Artificial Intelligence Biomedicine School of Life Sciences Nanjing University Nanjing Jiangsu China Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education, Key Laboratory of Chemical Biology of Hebei Province, College of Chemistry and Material Science, Hebei University , Baoding 071002, China State Key Laboratory of Coordination Chemistry; Collaborative Innovation Center of Advanced Mirostructures; School of Chemistry and Chemical Engineering; Nanjing University; Nanjing 210093 Shandong Engineering Research Center of Green Manufacturing for New Chemical Materials, School of Chemistry and Chemical Engineering Yantai University Yantai 264005 P. R. China CAS Key Laboratory of Soft Matter Chemistry, Hefei National Laboratory for Physical Sciences at Microscale and Department of Chemistry, University of Science and Technology of China Department of Rheumatology and Immunology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China. Jiangsu Key Laboratory of Biofunctional Materials; College of Chemistry and Materials Science; Nanjing Normal University; Nanjing 210023; P.R. China Botanical Review Team, Immediate Office, Office of New Drug Product, Office of Pharmaceutical Quality, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD, USA College of Life Science, Northwest University, Xi’an, Shaanxi province 710069, China Translational Disease Modelling Digital Data Science Sanofi Bridgewater New Jersey USA State Key Joint Laboratory of Environmental Simulation and Pollution Control, College of Environmental Sciences and Engineering, Peking University, Beijing, China 100871 Hoffmann Institute of Advanced Materials Shenzhen Polytechnic 7098 Liuxian Boulevard Shenzhen Guangdong 518055 P. R. China; Department of Chemistry and Chemical Biology Rutgers University 123 Bevier Road Piscataway NJ-08854 USA Department of Laboratory Medicine Panzhihua Central Hospital Panzhihua China School of Civil and Transportation Engineering, Hebei University of Technology, Tianjin 300401, China School of Life Sciences, Northwest University, Xi'an, Shaanxi 710069, China Department of Surgical Oncology, The First Affiliated Hospital of Bengbu Medical College, Bengbu, 233000, China Xiangya Hospital of Central South University, Changsha, PR China Department of Statistics, University of Michigan, Ann Arbor, MI 48109 Mental Health Center West China Hospital of Sichuan University Chengdu China Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China. Key Laboratory of Green Chemistry and Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610041, People’s Republic of China Mental Health Center,West China Hospital,Sichuan University,Chengdu 610041,China. School of Computer Science and Technology, China University of Mining and Technology, Xuzhou, Jiangsu 221116, P. R. China School of Life Sciences and State Key Laboratory of Biotherapy; West China Hospital; Sichuan University; Chengdu; P. R. China Key Laboratory of Fermentation Engineering (Ministry of Education), National “111” Center for Cellular Regulation and Molecular Pharmaceutics, Hubei Key Laboratory of Industrial Microbiology, College of Bioengineering and Food, Hubei University of Technology, Wuhan, Hubei 430068, People’s Republic of China Center of Excellence in Tissue Engineering, Department of Cell Biology, Institute of Basic Medical Sciences and School of Basic Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China. Beijing Jiaotong University Department of Chemistry, Physical & Theoretical Chemistry Laboratory, University of Oxford, Oxford, OX1 3QZ, United Kingdom Department of Biochemistry University of Toronto Toronto Ontario Canada M5S 1A8 State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management West China Hospital of Stomatology, Sichuan University Chengdu Sichuan China Key Laboratory of Green Chemistry and Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu, Sichuan 610064, P.R. China Mental Health Center, West China Hospital of Sichuan University, PRC. Department of Occupational and Environmental Health, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China; Department of Infectious Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK College of Food Science and Engineering Ocean University of China Qingdao China Department of Allergy & Clinical Immunology State Key Laboratory of Respiratory Disease The First Affiliated Hospital of Guangzhou Medical University Guangzhou China Department of Spine Surgery The Second Xiangya Hospital Central South University Changsha 410011 China Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (K.R.V., B.F., Q.W., M.F.M., A.L., A.J.G., P.D.B., J.L.); Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas (D.L.); Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, Texas (G.R.); Department of Radiology, The Uni Stomatology Department Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China Chengdu China Research Institute of Petrochina; Jilin Petrochemical Company; Jilin City 132012; P. R. China Liaoning Key Laboratory of Environmental Pollution and Microecology, School of Basic Medical Science, Shenyang Medical College, No. 146 Huanghe North Street, Shenyang 110016, PR China Department of Hematology Zhongshan Hospital Fudan University Shanghai China Department of Pathology Obstetrics and Gynecology Hospital of Fudan University Shanghai China Sustainable Energy Laboratory, Faculty of Materials Science and Chemistry, China University of Geosciences, Wuhan, 430074, China Department of Pharmacology, School of Basic Medical Sciences, Jilin University, Changchun, Jilin 130021, China Hypertension Center of People's Hospital of Xinjiang Uygur Autonomous Region; Xinjiang Hypertension Institute; NHC Key Laboratory of Hypertension Clinical Research; Key Laboratory of Xinjiang Uygur Autonomous Region “Hypertension Research Laboratory” Xinjiang Clinical Medical Research Center for Hypertension (Cardio‐Cerebrovascular) Diseases Urumqi 830001 China Henan Provincial People’s Hospital, Zhengzhou, China Department of Rheumatology & Immunology, Peking University People’s Hospital, Beijing 100044, China; Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135), China Department of Psychiatry, Beijing Huilongguan Hospital, Beijing 100096, China Center for Health Services Research University of Kentucky Lexington Kentucky; Office for Value & Innovation in Healthcare Delivery UK HealthCare Lexington Kentucky Department of Respiratory and Critical Care Medicine, Huashan Hospital, Fudan University, Jing'an, Shanghai 200040, P.R. China Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment, Xi’an, Shaanxi, China; Department of Radiation Protection Medicine, Air Force Medical University, Xi’an, Shaanxi, China Beijing National Laboratory for Molecular Science (BNLMS), State Key Laboratory for Structural Chemistry of Unstable and Stable Species, State Key Laboratory of Polymer Physics and Chemistry, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100080, People's Republic of China, and Department of Chemistry, Renmin University of China, Beijing 1000872, People's Republic of China Department of Dermatology, Chongqing First People's Hospital and Chongqing Traditional Chinese Medicine Hospital, Chongqing 400011, P.R. China School of Life and Health Science, Kaili University, Kaili, PR China Department of Pediatrics, Union Hospital, Tongji medical College, Huazhong University of Science and Technology , Wuhan, China College of Life Science & Biotechnology, Shanghai Jiao Tong University, Shanghai 201101, China. Department of Pharmacology of Traditional Chinese Medicine, School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China State Key Lab of Separation Membranes and Membrane Processes, School of Material Science and Engineering, Tianjin Polytechnic University, Tianjin 300387, China Department of Radiology; the Affiliated Cancer Hospital of Zhengzhou University; Zhengzhou China Department of Rehabilitation, Second Xiangya Hospital, Central South University, Changsha 410011, China. State Key Lab of Food Science and Technology, Institute for Advanced Study, Nanchang University, Nanchang, Jiangxi 330047, China State Key Laboratory of Advanced technology for Materials Synthesis and Processing Wuhan University of Technology 122 Luoshi Road Wuhan 430070 P. R. China State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing, China; University of Chinese Academy of Sciences, Beijing, China Department of Hepatobiliary Surgery, Kailuan General Hospital, Tangshan, Hebei 063210, China Jiangsu Collaborative Innovation Center of Biomedical Functional Materials and Jiangsu Key Laboratory of Biofunctional Materials, School of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, P. R. China Department of Ultrasound, Wuhan Asia Heart Hospital, Wuhan, China Shanxi Eye Hospital, Xi'an People's Hospital, Xi'an, Shanxi, China Institute of Wetland Research, Chinese Academy of Forestry, Beijing 100091, China. Department of Forensic Medicine, School of Basic Medicine and Biological Sciences Soochow University Suzhou China Department of Women and Child Health School of Public Health Kunming Medical University Kunming China Authors' Affiliations: Departments of 1Surgery, 2Biochemistry, and 3Pathology and 4Markey Cancer Center, University of Kentucky, Lexington, Kentucky; 5M.D./Ph.D. Program, 6Department of Surgery, 7Department of Pathology, and 8Sealy Center for Cancer Cell Biology, University of Texas Medical Branch, Galveston, Texas; Authors' Affiliations: Departments of 1Surgery, 2Biochemistry, and 3Pathology and 4Markey Cancer Center, University of Kentucky, Lexington, Kentucky; 5M.D./Ph.D. Program, 6Department of Surgery, 7Department of Pathology, and 8Sealy Center for Cancer Cell Biology, University of Texas Medical Branch, Galveston, Texas Huzhou Center for Disease Control and Prevention, Huzhou, Zhejiang Province, People's Republic of China. School of Life Science, Northwest University, Xi'an 710069. Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials; School of Chemistry and Materials Science; Jiangsu Normal University; Xuzhou 221116; P. R. China Health Science Center, Shanghai Institutes for Biological Sciences, CAS/Shanghai Second Medical University, Shanghai 200025, China. Chinese Academy of Medical Sciences Institute of Dermatology/National Center for STD Control, Chinese Center for Disease Control and Prevention, Nanjing 210042, China. Division of Glycoscience, Department of Chemistry, School of Engineering Sciences in Chemistry, Biotechnology and Health, Royal Institute of Technology (KTH), AlbaNova University Center, Stockholm SE10691, Sweden; College of Life Sciences, Shanghai Normal University, Shanghai 220234, PR China Department of Clinical Laboratory The First Affiliated Hospital of Bengbu Medical College Bengbu China General Hospital of Shenyang Military Region Shenyang China College of Nursing Xi'an Medical University Xi'an Shaanxi China Botanical Review Team, Science Staff, Immediate Office, Office of Pharmaceutical Quality, Center for Drug Evaluation and Research, Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, Maryland 20993, United States Jiangsu Collaborative Innovation Center of Biomedical Functional Materials and Jiangsu Key Laboratory of Biofunctional Materials, College of Chemistry and Materials Science, Nanjing Normal University, Nanjing, 210023 Jiangsu, People’s Republic of China The Second Affiliated Hospital of Shandong First Medical University Jinan China Department of Rheumatology Affiliated Hospital of Nantong University Nantong China Semiconductor Lighting Research and Development Center, Institute of Semiconductors, Chinese Academy of Sciences, No. A35, Qinghua East Road, Haidian District, Beijing 100083, China; College of Materials Science and Opto-Electronic Technology, University of Chinese Academy of Sciences, No. 19A, Yuquan Road, Shijingshan District, Beijing 100049, China Singapore Eye Research Institute, 11 Third Hospital Avenue, #06-00, Singapore 168751; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, 5 Lower Kent Ridge Road, Singapore 119074 School of Traditional Chinese Medicine Capital Medical University Beijing China Department of Otolaryngology, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, P.R. China Department of Atmospheric and Oceanic Sciences, Laboratory for Climate and Ocean-Atmosphere Studies, School of Physics, Peking University, Beijing 100871, China Public Health School of Lanzhou University Arizona State University, Tempe, AZ, USA Authors' Affiliation: Department of Oncology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan Clinical Laboratory, Shaanxi Provincial Hospital of Tuberculosis Prevention and Treatment, Xi' an, China. School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, P. R. China Shandong Provincial Key Laboratory/Collaborative Innovation Center of Chemical Energy Storage and Novel Cell Technology, and School of Chemistry and Chemical Engineering, Liaocheng University, Liaocheng 252000, P. R. China Department of Pharmaceutical Engineering, School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou, Guangdong 510640, People’s Republic of China Prostate Cancer Discovery and Development Program Key Laboratory of the Ministry of Education for Coastal and Wetland Ecosystems, College of the Environment and Ecology, Xiamen University, Xiamen, China Department of Clinical Laboratory, First Affiliated Hospital of Bengbu Medical College , Bengbu , China Department of Operative Dentistry and Endodontics, Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University and Guangdong Provincial Key Laboratory of Stomatology, Guangzhou, China Department of Stomatology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China School of Life Sciences, Sun Yat-sen University, China; Department of Genetics and Biochemistry, Clemson University, USA Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming 650118, China Beijing Tongren Eye Center Beijing Key Laboratory of Ophthalmology and Visual Sciences Beijing Tongren Hospital of Capital Medical University Beijing China Department of Cardiology General Hospital of Northern Theater Command Shenyang China; The Graduate School of Harbin Medical University Harbin China School of Industrial and Systems Engineering Georgia Tech Atlanta Georgia USA Department of Interventional Radiology and hemangioma Contrbution from the Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, New Jersey 08854, and National Renewable Energy Laboratory, Golden, Colorado 80401 Department of Radiology, Changhai Hospital of Shanghai, Naval Medical University, Shanghai, China Department of Biochemistry and Molecular Biology, ◆Department of Medicine, §Herman B Wells Center for Pediatric Research, ∥In vivo Therapeutics Core, ●Indiana University Cancer Center, #Center for Computational Biology and Bioinformatics, ⊥Department of Chemistry and Chemical Biology (IUPUI), +Stark Neurosciences Research Institute, ¶Department of Surgery, and ∇Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, 535 Barnhill Drive, Indianapolis, Indiana 46202, United... Central Laboratory Chongqing University Three Gorges Hospital Wanzhou, Chongqing China; College of Life Sciences Chongqing Medical University Yuzhong, Chongqing China Department of Cardiovascular Ultrasound, The People’s Hospital of China Medical University and The People’s Hospital of Liaoning Province, Shenyang, China College of Food Science, Southwest University, Chongqing 400715, People’s Republic of China Division of Earth, Life, and Molecular Sciences, Graduate School of Natural Science and Technology, Okayama University, 3-1-1 Tsushimanaka, Okayama 700-8530, Japan School of Civil Engineering, Inner Mongolia University of Technology, Hohhot, China Department of Food Science and Engineering, School of Food Science Dalian Polytechnic University Dalian China Department of Operative Dentistry and Endodontics, Guanghua School of Stomatology Hospital of Stomatology, Sun Yat‐sen University, Guangdong Province Key Laboratory of Stomatology Guangzhou Guangdong People's Republic of China Department of Obstetrics Lianyungang Maternal and Child Health Hospital Lianyungang Jiangsu China MRL, Merck & Co., Inc., West Point, Pennsylvania 19486, United States College of Veterinary Medicine, Yangzhou University, Yangzhou, China. National Clinical Research Center of Cardiovascular Diseases, National Health Commission Key Laboratory of Clinical Research for Cardiovascular Medications, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of China (J.L., X.B., X.L., X.Z., H.Z., X.Y.). No. 198, Hongqi Road, Huzhou Key Laboratory of Molecular Medicine, Huzhou Central Hospital, Huzhou, Zhejiang Province, 313000, China Sustainable Energy Laboratory; Faculty of Materials Science and Chemistry; China University of Geosciences (Wuhan); Wuhan; P. R. China Division of Cardiology, Hospital for Sick Children, Toronto, Canada M5G 1X8 Institute of Diagnostic and Interventional Radiology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai 200233, China Department of Evidence‐Based Medicine and Clinical Epidemiology, West China Hospital Sichuan University Chengdu Sichuan China Department of Chemistry and Chemical Biology, Rutger, The State University of New Jersey, 610 Taylor Road, Piscataway, New Jersey 08852, and College of Chemistry, South China University of Technology, Guangzhou, 510006, P. R. China Endoscopic Diagnosis and Treatment Center Affiliated Cancer Hospital of Zhengzhou University Zhengzhou China Department of Rheumatology Peking Union Medical College Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Beijing China; Key Laboratory of Rheumatology and Clinical Immunology Ministry of Education Beijing China Nursing College of Beihua University, Jilin 132013, China State Key Laboratory of Food Nutrition and Safety; Tianjin University of Science & Technology; Tianjin 300457; China Jing Li, Liang Huang, Cai-Feng Liu, Jie Cao, Jian-Jun Yan, Feng Xu, Meng-Chao Wu, Yi-Qun Yan, Department of Hepatic Surgery I, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438, China. Department of Radiology, Mayo Clinic, Phoenix, Arizona (L.S.H., T.W., J.M.H.); Department of Biostatistics, Mayo Clinic, Phoenix, Arizona (A.C.D.); Department of Research, Mayo Clinic, Arizona (J.R.M., K.S.); Department of Neurosurgery, Mayo Clinic, Phoenix, Arizona (K.R.S.); Department of Cancer and Cell Biology, Mayo Clinic, Scottsdale, Arizona (J.C.L.); Department of Pathology, Mayo Clinic, Ro Key Laboratory for Advanced Technology in Environmental Protection of Jiangsu Province, School of Chemistry and Chemical Engineering, Yancheng Institute of Technology, Yancheng 224051, PR China State key Laboratory of Bioelectronics; Jiangsu Key Laboratory for Biomaterials and Devices; School of Biological Sciences & Medical Engineering; Southeast University; Nanjing State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Fujian, Fuzhou, 350002, China, and Department of Chemistry and Chemical Biology, Rutgers University, 610 Taylor Road, Piscataway, New Jersey 08854 School of Chemistry and Chemical Engineering; Harbin Institute of Technology; Harbin 150001; China; Department of Chemistry School and Hospital of Stomatology, Lanzhou University, No. 222 Tianshui South Road, Chengguan District, Lanzhou 730000, Gansu, P. R. China Department of Radiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences/Peking Union Medical College, Beijing, China Department of Orthopaedic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China Department of Orthopaedic Oncology, Xijing Hospital Affiliated to the Fourth Military Medical University, Xi’an, PR China Tongji Medical College of Huazhong University of Science and Technology School, Wuhan, China; School of Public Health and Management, Research Center for Medicine and Social Development, Innovation Center for Social Risk Governance in Health, Chongqing Medical University, Chongqing, China Life Sciences Institute, The Key Laboratory of Conservation Biology for Endangered Wildlife of the Ministry of Education, Zhejiang University, 866 Yuhangtang Road, Hangzhou, Zhejiang, 310058, China. Hubei Key Laboratory of Cardiovascular, Cerebrovascular, and Metabolic Disorders, Hubei University of Science and Technology, Xianning, Hubei, P. R. China Department of Neurology, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China. College of Life Science and Engineering, Northwest Minzu University, Lanzhou, China; Key Laboratory of Biotechnology and Bioengineering of State Ethnic Affairs Commission, Biomedical Research Center, Northwest Minzu University, Lanzhou, China; China-Malaysia National Joint Laboratory, Biomedical Research Center, Northwest Minzu University, Lanzhou, China Department of Radiation Oncology, West China Hospital of Sichuan University, Chengdu, 610041. School of Life Sciences, University of Science and Technology of China; Anhui People's Republic of China Department of Surgery, Dongying People’s Hospital, Dongying 257091, P.R. China Institute of Pomology; Chinese Academy of Agricultural Sciences; 125100 Xingcheng; PR China; Laboratory of Quality and Safety Risk Assessment for Fruit School of Chemistry and Chemical Engineering Hefei University of Technology Hefei 230009 P.R. China Tang Center for Herbal Medicine Research, Pritzker School of Medicine, University of Chicago, IL.; Department of Anesthesia & Critical Care, Pritzker School of Medicine, University of Chicago, IL. State Key Laboratory of Electroanalytical Chemistry; Changchun Institute of Applied Chemistry; Chinese Academy of Sciences; Changchun 130022; P. R. China State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Wuhan 430070, PR China. School of Industrial and Systems Engineering, Georgia Institute of Technology , Atlanta, GA 30332 , USA Key Laboratory of Tectonics and Petroleum Resources, Ministry of Education, China University of Geosciences, Wuhan 430074, China Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming, People’s Republic of China Department of Pathogen Biology and Immunology, School of Basic Medical Sciences, Ningxia Medical University, Yinchuan 750004, China Department of Occupational and Environmental Health, West China School of Public Health Sichuan University Chengdu People's Republic of China School of Pharmacy; Shanghai Jiao Tong University; Shanghai 200240; P. R. China Department of Central Sterile Supply, Research Institute of Surgery, Daping Hospital, Third Military Medical University, Chongqing 400042, P.R. China CAS Key Laboratory of Brain Function and Diseases, School of Life Sciences University of Science and Technology of China Hefei China; Auditory Research Laboratory University of Science and Technology of China Hefei China Xuzhou medical College Xuzhou 221002 China; Jiangsu Province Key Laboratory of Anesthesiology and Center for Pain Research and Treatment Xuzhou Medical College Xuzhou 221002 China Division of Endocrinology, Diabetes, and Hypertension, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts Division of Rheumatology University of California ‐ San Francisco San Francisco California Department of Pathology, Shanxi Tumor Hospital, Taiyuan 030013, China. Department of Anesthesiology, Honghui Hospital; Key Laboratory of Biomedical Information Engineering, Ministry of Education; Institute of Biomedical Engineering, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710054, China. Department of Pathophysiology, School of Medicine, Jinan University , Guangzhou, Guangdong 510630 , China Key Laboratory of Materials Modification by Laser, Ion, and Electron Beams (Ministry of Education), Dalian University of Technology, Dalian 116024, People’s Republic of China; Shenyang National Laboratory for Materials Science (SYNL), Institute of Metal Research (IMR), Chinese Academy of Sciences (CAS), No. 72 Wenhua Road, Shenyang 110016, People’s Republic of China Department of Chemistry, Wayne State University, 48202, Detroit, MI, USA Department of Obstetrics and Gynecology, Program of Reproductive and Stem Cell Biology, Stanford University School of Medicine, Stanford, CA 94305-5317; Departments of aBiochemistry and Molecular Biology and; Centers for Cancer Epigenetics, Stem Cell and Developmental Biology, and Genetics and Genomics, University of Texas MD Anderson Cancer Center, Houston, TX 77030;; Genes and Development Graduate Program, University of Texas Graduate School of Biomedical Sciences, Houston, TX 77030; and Liver Cirrhosis Group, Department of Gastroenterology, General Hospital of Shenyang Military Area, Shenyang, Liaoning, China (mainland) Department of Surgery, The University of Texas Medical Branch, Galveston, Texas 77555-0536 1Division of Medical Oncology, Department of Medicine, Duke Cancer Institute, Duke University, Durham, North Carolina. Authors' Affiliations: 1Department of Epidemiology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, PR China; 2PATH, Seattle, Washington; 3Arbor Vita Corporation, Fremont, California; 4Department of Pathology, University of Virginia, Charlottesville, Virginia; and 5Global Cancer Initiative, Chestertown, Maryland Shanghai Key Laboratory of Infectious Diseases and Biosafety Emergency Response, Department of Infectious Diseases, National Medical Center for Infectious Diseases, Huashan Hospital Fudan University Shanghai China; Liver Research Center, Division of Gastroenterology Rhode Island Hospital and Warren Alpert Medical School of Brown University Providence Rhode Island USA; Department of Infectious Diseases, First Affiliated Hospital of Medical College Xi'an Jiaotong University Xi'an Shaanxi Province China Institute of Crop Sciences Chinese Academy of Agricultural Sciences Beijing China School of Chemistry and Chemical Engineering; Jiangxi University of Science and Technology; Ganzhou 341000; P.R. China Department of Gastroenterology The First Affiliated Hospital of Zhengzhou University Zhengzhou China State Key Lab of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, China Department of Pharmacy National Clinical Research Center for Geriatric Disorders Xiangya Hospital Central South University Changsha 410008 China Anhui Province Key Laboratory of Chinese Medicinal Formula, Anhui University of Chinese Medicine, Hefei, China; Department of Pediatrics, Steele Children's Research Center, University of Arizona, Tucson, Arizona; State Key Laboratory of Multiphase Complex Systems; Institute of Process Engineering; Chinese Academy of Sciences; Beijing; P. R. China College of Science Jinling Institute of Technology Nanjing 211169 P. R. China Key Laboratory of Insect Developmental and Evolutionary Biology, Chinese Academy of Sciences Center for Excellence in Molecular Plant Sciences, Shanghai Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, 200032 Shanghai, China;; University of Chinese Academy of Sciences, 100049 Beijing, China; School of Microelectronics Dalian University of Technology No. 2 Linggong Road Dalian 116024 China State Key Laboratory of Natural Medicines, Department of Pharmaceutics, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, Jiangsu, P.R. China; NMPA Key Laboratory for Research and Evaluation of Pharmaceutical Preparations and Excipients, China Pharmaceutical University, Nanjing 210009, Jiangsu, P.R. China College of Pharmaceutical Science, Nankai University Department of Immunology, Institute of Clinical Pharmacology, Guangzhou University of Chinese Medicine, Guangzhou, P.R. China; College of Resources and Environment, Anhui Agricultural University, Hefei 230036, China Department of Traditional Chinese Medicine, The Affiliated People's Hospital of Ningbo University, Ningbo, Zhejiang, China. Tongji School of Pharmacy Huazhong University of Science and Technology Wuhan China Xi’an Jiaotong University; Currently with Globalfoundries Department of Pediatrics, Steel Children's Research Center, The University of Arizona, Tucson, Arizona Institute of Precision Medicine, Jining Medical University, Jining 272067, China; Department of Emergency Medicine, Center for Advanced Resuscitation Medicine and Program in Sudden Cardiac Death, Center for Cardiovascular Research, University of Illinois Hospital & Health Sciences System, University of Illinois at Chicago, IL 60612, USA Laboratory of Translational Medicine, The First Medical Center of Chinese PLA General Hospital, Beijing, China. Department of General Internal Medicine, Sichuan Cancer Hospital &institute & School of Medicine, University of Electronic Science and Technology of China, Chengdu, China Department of Radiology (Z.S., J. Li, W.P., T.J., Q.L., J. Lu), Changhai Hospital, Naval Medical University, Shanghai, China. School of Physics and Physical Engineering, Qufu Normal University, Qufu 273165, P.R. China School of Pharmacy Guangdong Medical University Dongguan China The State Key Laboratory and Institute of Elemento-Organic Chemistry; College of Chemistry; Nankai University; Tianjin 300071; China State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica Chinese Academy of Sciences Shanghai China Department of Biochemistry and Molecular Biology, College of Life Science and Technology, Heilongjiang Bayi Agricultural University, Daqing, Heilongjiang 163319, P.R. China Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China. 95 Yongan Road, Xi Cheng District, Beijing 100050, China Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, P.R. China.; Anhui Provincial Laboratory of Population Health and Major Disease Screening and Diagnosis, Anhui Medical University, Hefei, P.R. China. Department of Orthopaedics & Traumatology, Xijing Hospital, Fourth Military Medical University, Xi’an, China, Musculoskeletal Research Laboratory, Department of Orthopaedics and Traumatology, Chinese University of Hong Kong, Hong Kong SAR, China, Department of Pharmaceutical Chemistry, Fourth Military Medical University, Xi’an, China Department of Gynecological Oncology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing, China Department of Endocrinology, Beijing Chao-yang Hospital, Capital Medical University , Beijing 100020 , China Department of Pharmaceutical Sciences, Wayne State University, Detroit, Michigan 48201, United States Department of Oncology, The First Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410021, P.R. China Key Laboratory for Liquid–Solid Structural Evolution and Processing of Materials (Ministry of Education) Research Center for Carbon Nanomaterials School of Materials Science and Engineering Shandong University Jinan 250061 China Sichuan University Chengdu China Department of Computer and Data Sciences , Case Western Reserve University, Cleveland, OH 44106, USA The Center of Clinical Research of Endocrinology and Metabolic Diseases in Chongqing and Department of Endocrinology Chongqing Three Gorges Central Hospital Chongqing China Jiangxi Special Hospital of Dermatology Nanchang, JiangxiP.R. China Key Laboratory of the Ministry of Education for Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Institute of Materia Medica, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing 100050, China. Shandong Collaborative Innovation Center of Light Hydrocarbon Transformation and Utilization; School of Chemistry & Chemical Engineering; Yantai University; Yantai 264005; China Kunming Police Dog Base of the Ministry of Public Security Kunming China National Clinical Research Center of Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing, China Max‐Eder Research Group for Pediatric Sarcoma Biology Institute of Pathology, Faculty of Medicine, LMU Munich Munich Germany The Channing Laboratory, Brigham and Women’s Hospital, Departments of Medicine, Genetics, and Microbiology and Molecular Genetics, Harvard Medical School, and Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02115 College of Chemistry and Chemical Engineering, Chongqing University, Chongqing 401331, P. R. China Xijing Hypertrophic Cardiomyopathy Center, Department of Ultrasound, Xijing Hospital, Fourth Military Medical University, Xi’an, Shaanxi, China Department of Radiation Oncology University of Texas MD Anderson Cancer Center Houston TX USA Key Laboratory of the Ministry of Education for Coastal and Wetland Ecosystems, College of the Environment and Ecology Xiamen University Xiamen Fujian China China Oxford Centre for International Health Research, Fu Wai Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100037, China. Department of Computer and Data Sciences, Case Western Reserve University, Cleveland, Ohio Sunshine Lake Pharma Co., Ltd. Dongguan China Ministry of Education Key Laboratory for Analytical Science of Food Safety and Biology, Fujian Provincial Key Laboratory of Analysis and Detection for Food Safety, Eel Farming and Processing, Fuzhou University, Fuzhou, Fujian, 350108, P. R. China Department of Neurosurgery, Shandong Cancer Hospital Affiliated to Shandong University, Shandong Academy of Medical Sciences, Jinan, Shandong 250117, P.R. China Department of Vascular Anomalies and Interventional Radiology, Children's Hospital Affiliated to Shandong University, Jinan, China. Key Laboratory of Hunan Province for Integrated Traditional Chinese and Western Medicine on Prevention and Treatment of Cardio‐Cerebral Diseases, School of Integrated Chinese and Western Medicine Hunan University of Chinese Medicine Changsha Hunan 410208 China; Beijing Institute of Nanoenergy and Nanosystems Chinese Academy of Sciences Beijing 101400 China School of Geographical Sciences/School of Carbon Neutrality Future Technology, Fujian Normal University, Fuzhou 350117, China. Key Laboratory of Subtropical Resources and Environment of Fujian Province, Fuzhou 350117, China. Department of Pulmonary Medicine, Peking University People’s Hospital, Beijing, China Demirui Cardiopulmonary Resuscitation Medical Conversion Center, Beijing 100160, China. Institute of Clinical Pharmacology Zhengzhou University Zhengzhou Henan China Department of Biopharmaceutical Sciences, College of Pharmacy, Harbin Medical University (Daqing), Daqing, China; Department of Dermatology, Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital, Tianjin, China Department of Stomatology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, P.R. China Department of Neonatology, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China Department of Gastroenterology Nanfang Hospital, Southern Medical University Guangzhou, Guangdong Province Department of Otolaryngology-Head and Neck Surgery, The Central Hospital of Wuhan, Tongji Medical College Huazhong University of Science and Technology, Wuhan, Hubei, China (mainland) Department of Obstetrics and Gynecology, Wuhan Third Hospital, Wuhan, Hubei, China General Surgery Department Peking University First Hospital Beijing China Center for Applied Chemical Research, Frontier Institute of Science and Technology, and State Key Laboratory for Mechanical Behavior of Materials, Xi’an Jiaotong University and ‡MOE Key Laboratory for Nonequilibrium Synthesis and Modulation of Condensed Matter, Xi’an Jiaotong University, Xi’an 710049, China Shenzhen Institute for Drug Control Shenzhen P. R. China; Shenzhen Key Laboratory of Drug Quality Standard Research Shenzhen P. R. China; Shenyang Pharmaceutical University Shenyang P. R. China Department of Gynecology and Obstetrics Nanfang Hospital Southern Medical University Guangzhou 510515 China Key Laboratory of Groundwater Resources and Environment, Ministry of Education, College of Environment and Resources, Jilin University, Changchun, People’s Republic of China Department of TB Control, Shanghai Municipal Centers for Disease Control and Prevention, Shanghai 200336, China Department of Infectious Diseases Shunde Hospital Southern Medical University Shunde China College of Pharmacy, Anhui University of Chinese Medicine, Hefei, China CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Pudong, Shanghai, China 201203. Radiophysical Technology Center , Cancer Center, West China Hospital, Sichuan University, Chengdu, 610041 , China Department of Neurology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510080, China. zhangch6@mail.sysu.edu.cn. College of Chemistry and Biology Engineering, Yancheng Institute of Technology, 9 Yingbin Avenue, Yancheng 224051, PR China School of Marine Sciences, Sun Yat-sen University, Zhuhai519082, P.R. China; Guangdong Provincial Key Laboratory of Marine Resources and Coastal Engineering, Zhuhai519082, China Department of Cardiovascular Diseases; HEC Pharma. Co. Ltd.; Dongguan 523871; China Department of Obstetrics and Gynecology, The Third Hospital of Xiamen, The First Affiliated Hospital of Xiamen University (Tongan Branch), Xiamen City, Fujian Province, China. Department of Agriculture, Faculty of Agriculture, Kochi University, B200 Monobe, Nankoku 783-8502, Japan Department of Pharmacology, School of Pharmacy, Qingdao Medical College, Qingdao University, Qingdao, Shandong, China. Renal Division, Peking University Shenzhen Hospital, Peking University , Shenzhen, Guangdong Province , China Department of Microbiology and Immunology, School of Basic Medical Sciences, Shanxi Medical University School of Pharmacy, Guangdong Medical University, Dongguan, 523808, China Department of Gynecology, Wuhan Childrens Hospital, Wuhan Maternal and Child Health Hospital, Wuhan Womens and Childrens Health Care Center, Wuhan, Hubei Province, China Institute of Acupuncture and Moxibustion, the First Teaching Hospital of Tianjin University of TCM. Department of Oncology, Shihezi University School of Medicine, the First Affiliated Hospital, Shihezi Department of Neurology Xiangya Hospital Central South University Changsha Hunan China Department of Radiology, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou 550004, P.R. China Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China Department of Traditional Chinese Medicine, Children’s Hospital Affiliated to Zhengzhou University, Henan Children’s Hospital Zhengzhou Children’s Hospital, Henan, China Department of Hepatopancreatobiliary Surgery, Third Xiangya Hospital, Central South University, Changsha, Hunan, China School of Medicine; University of Leeds; Leeds, UK Translational Informatics, TMED, Sanofi, Bridgewater New Jersey USA Harvard Medical School Boston MA USA; Department of Neurology Brigham and Women's Hospital Boston MA USA Department of Science and Education, Yichang Maternal and Child Health Care Hospital, Clinical Medical College of Women and Children, Three Gorges University, Yichang, China Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China Department of Endocrinology, Beijing Chao‐yang Hospital Capital Medical University Beijing China Research Institute of Pomology, Chinese Academy of Agricultural Sciences, Xingcheng 125100, China Division of Endocrinology and Metabolism, West China Hospital of Sichuan University , Chengdu , China Department of Mechanical Engineering City University of Hong Kong Hong Kong 999077 China College of Animal Science and Technology, Henan Agricultural University, Zhengzhou, China State Key Laboratory of Respiratory Disease, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, China. School of Marine Sciences, Sun Yat-sen University, Guangzhou, China; South China Sea Resource Exploitation and Protection Collaborative Innovation Center, Sun Yat-sen University, Guangzhou, China Department of Materials Science and Engineering; Southern University of Science and Technology; Shenzhen; China YouYi Clinical Laboratories of Shaanxi, Xi'an, China; State Key Laboratory of Ophthalmology Zhongshan Ophthalmic Center Sun Yat‐sen University Guangzhou China Department of Integrated Systems Engineering, College of Engineering, The Ohio State University, Columbus, OH, USA Department of Endocrinology and Metabolism Institute of Endocrinology Liaoning Provincial Key Laboratory of Endocrine Diseases The First Hospital of China Medical University Shenyang China Department of Ophthalmology Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine Shanghai China Department of Environmental Engineering, Wuhan University, Wuhan 430079, China; Shenzhen Research Institute of Wuhan University, Shenzhen 518057, China State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, Guangdong, People's Republic of China College of Pharmaceutical Sciences Zhejiang University Hangzhou China Department of Ultrasound, The Second Affiliated Hospital of Soochow University, Suzhou, China Authors' Affiliations: 1Oncology Biology, 2In vivo Pharmacology, 3Informatics and Analysis at Merck Research Laboratories, Boston, Massachusetts; and 4Discovery Profiling at Merck Research Laboratories, North Wales, Pennsylvania Department of Pediatrics, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China. milikita17@aliyun.com. Key Laboratory of Optoelectronic Technology and System of Ministry of Education, College of Optoelectronic Engineering, Chongqing University, Chongqing 400044, China Laboratory of Biomimetic Nanomaterials, Department of Orthodontics, Peking University School and Hospital of Stomatology, National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology, Beijing, China China Aviation Planning and Design Institute(Group) Co., Ltd., Beijing 100120, China. Key Laboratory of Chinese Materia Medica (Ministry of Education), Heilongjiang University of Chinese Medicine, No. 24, Heping Road, Xiangfang District, Harbin 150040, P.R. China Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210028, China; Laboratory of Cellular and Molecular Biology, Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing, Jiangsu 210028, China lijing@cma.org.cn Heart Center, Beijing Chaoyang Hospital, Capital Medical University, Beijing Key Laboratory of Hypertension Beijing China Department of Chemistry, Yonsei University, Seoul 120-749, Republic of Korea Department of Anatomy, Hebei Medical University, Shijiazhuang 050017, China. Yunnan International Joint R&D Center of Smart Agriculture and Water Security; School of Water Conservancy, Yunnan Agricultural University, Kunming 650201, P. R. China State Key Laboratory of Reproductive Medicine; Nanjing Medical University; Nanjing China State Key Laboratory of Marine Resource Utilization in South China Sea Hainan Provincial Key Lab of Fine Chemistry School of Chemical Engineering and Technology Hainan University Haikou 570228 China General Hospital of Northern Theater Command Shenyang China Shanghai Key Laboratory of Molecular Engineering of Chiral Drugs, Frontiers Science Center for Transformative Molecules, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, P. R. China Shenyang National Laboratory for Materials Science (SYNL); Institute of Metal Research (IMR); Chinese Academy of Sciences (CAS); Shenyang 110016, China; School of Materials Science and Engineering Beijing National Laboratory for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China, State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116012, P. R. China, and State Key Laboratory of Bioreactor Engineering and Shanghai Key Laboratory of Chemical Biology, East China University of Science and Technology, Shanghai 200237, P. R. China Anhui Key Laboratory of Tissue Transplantation, Bengbu Medical College, Bengbu, China; Department of Clinical Laboratory, First Affiliated Hospital of Bengbu Medical College, Bengbu, China Student, Department of Orthodontics, School of Stomatology, Shandong University, Jinan, Shandong, China College of Marine Life Sciences, Ocean University of China, Qingdao, Shandong 266003, PR China State key Laboratory of Chemo/Biosensing and Chemometrics College of Chemistry and Chemical Engineering Key Laboratory for Bio-Nanotechnology and Molecular Engineering of Hunan Province Hunan University Changsha P. R. China Department of Spine Surgery, the 2nd Xiangya Hospital of Central South University, Changsha, China Department of Critical Care Medicine & National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Hunan, China Universidade de Coimbra Departamento de Química, 3004-535 Coimbra, Portugal Department of Chemistry and State Key Laboratory for Physical Chemistry of Solid Surface, Xiamen University, Xiamen 361005, China, Department of Physics, Temple University, Philadelphia, Pennsylvania 19122, and Department of Chemistry and Chemical Biology, Rutgers University, 610 Taylor Road, Piscataway, New Jersey 08854 Quality Assurance Department, Sinovac Biotech Co., LTD., Beijing, China Institute of Basic Medical Sciences and School of Basic Medicine, Center of Excellence in Tissue Engineering, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, P.R. China. Department of Rheumatology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, National Clinical Research Center for Dermatologic and Diseases (NCRC-DID), Beijing, China CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China; Beijing Key Laboratory of Microbial Drug Resistance and Resistome, Beijing, China Department of Radiation Oncology University of Texas, MD Anderson Cancer Center Houston Texas USA The First Clinical Medical School the First Hospital of Lanzhou University Lanzhou University Lanzhou 730000 China Department of Chemistry, P.O. Box 30012, Texas A&M University, College Station, Texas 77842-3012 State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China Guangdong-Hong Kong-Macau Joint Laboratory for Photonic-Thermal-Electrical Energy Materials and Devices, Institute of Applied Physics and Materials Engineering, University of Macau, Avenida da Universidade, Taipa, Macau SAR 999078, People’s Republic of China Key Laboratory of Pharmaceutics of Guizhou Province, Guizhou Medical University, Guiyang 550004, China; Lab for Bone Metabolism, Key Lab for Space Biosciences and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, 127 West Youyi Road, Xi’an 710072, China Frontiers Science Center for Synthetic Biology, Institute of Biomolecular and Biomedical Engineering, Key Laboratory of Systems Bioengineering (MOE), School of Chemical Engineering and Technology, Tianjin University, Tianjin 300350, China; State Key Laboratory of Chemical Resource Engineering, Beijing Advanced Innovation Center for Soft Matter Science and Engineering, College of Chemistry, Beijing University of Chemical Technology, Beijing 100029, China Jiangsu Co-Innovation Center for the Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University College of Veterinary Medicine, Yangzhou, Jiangsu 225009, China School of Marine Sciences, Sun Yat-Sen University, Guangzhou, P.R. China; South China Sea Bio-Resource Exploitation and Utilization Collaborative Innovation Center, Sun Yat-Sen University, Guangzhou, P.R. China Department of Hepatic Surgery Eastern Hepatobiliary Surgery Hospital Shanghai China College of Animal Science and Technology, Northwest A&F University, Yangling, China Department of Critical Care Medicine, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China. School of Marine Sciences; Sun Yat-Sen University; Guangzhou 510006; China State Key Laboratory of Oral Diseases West China Hospital of Stomatology Sichuan University Chengdu Sichuan China Drug Development Core, Faculty of Health Sciences, University of Macau, Macau SAR, PR China Department of Colorectal Surgery, Yidu Central Hospital of Weifang City, Qingzhou, China Key Laboratory of Biomass Energy and Material, Jiangsu Province; Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, Institute of Chemical Industry of Forest Products, CAF; Nanjing Forestry University, Nanjing, People’s Republic of China Respiratory Department, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, PR China Zhongshan Community Health Care Center, Songjiang District, Shanghai 201613, China Key Laboratory of Resource Biology and Biotechnology in Western China (Northwest University), Ministry of Education, Xi’an, Shaanxi 710069, China; Xi’an Tiangen Precision Medical Institute, Xi’an, Shaanxi 710075, China Division of Advanced Materials, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou 215123, China Leeds Multidisciplinary Cardiovascular Research Centre, LIGHT Laboratories The University of Leeds, Clarendon Way, Leeds, United Kingdom School of Environmental Science and Engineering, Shandong University, Ji'nan 250100, China. lijing84@mail.sdu.edu.cn Research Center for Marine Drugs, State Key Laboratory of Oncogene and Related Genes, Department of Pharmacy, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, P. R. China Department of Rheumatology and Clinical Immunology Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Key Laboratory of Rheumatology and Clinical Immunology Ministry of Education Beijing China Department of Orthopedics The Second Affiliated Hospital of Xi'an Jiaotong University Xi'an Shaanxi China Department of Materials Science & Engineering, University of Texas at Dallas, Richardson, Texas 75080, and Department of Physics and Astronomy and Department of Chemistry and Chemical Biology, Rutgers University, 610 Taylor Road, Piscataway, New Jersey 08854 Key Laboratory of the Ministry of Education for Coastal and Wetland Ecosystems, College of the Environment and Ecology, Xiamen University Xiamen China Department of Radiology, Changhai Hospital, The Navy Military Medical University, 168 Changhai Rd, Shanghai 200433, China Minhang Integrated Traditional Chinese and Western Medicine Hospital, Longhua Hospital Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China State Key Laboratory of Cancer Biology, Department of Pathology, Xijing Hospital and School of Basic Medicine Fourth Military Medical University Xi'an Shaanxi China State Key Laboratory of Polymer Physics and Chemistry, Joint Laboratory of Polymer Science and Materials, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080, China Chongqing Key Laboratory of Chemical Process for Clean Energy and Resource Utilization School of Chemistry and Engineering Chongqing University Shazhengjie 174 Chongqing 400044 China Medical College of Qingdao University, Qingdao 266021, China. lj.112004@163.com School of Pharmaceutical Sciences, Central South University, Changsha 410013, China Department of Ultrasonic Medicine, The 1st Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin 150040, China Department of Oncology, The First Affiliated Hospital of Zhengzhou UniversityZhengzhouP.R. China State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, P. R. China Food Crops Research Institute, Yunnan Academy of Agricultural Sciences (YAAS) Center for Reproductive Medicine, The First Affiliated Hospital of Zhengzhou University, and Henan Province Key Laboratory of Reproduction and Genetics, Henan, People’s Republic of China Citrus Research Institute, Southwest University, Chongqing, PR China; Quality Supervision and Testing Center for Citrus and Seedling, Ministry of Agriculture and Rural Affairs, Chongqing, PR China; Key Laboratory of Quality and Safety Control of Citrus Fruits, Ministry of Agriculture and Rural Affairs, Chongqing, PR China; Laboratory of Quality and Safety Risk Assessment for Citrus Products, Ministry of Agriculture and Rural Affairs, Chongqing, PR China; National Citrus Engineering Research Center, Chongqing, PR China Obstetrical Department, Affiliated Hospital of Qingdao University, Qingdao, Shandong, China; Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Key Laboratory of Pesticide Chemistry and Application Ministry of Agriculture Beijing 100193 China Chongqing Key Laboratory of Neurodegenerative Diseases, Chongqing, Chongqing, China; Department of Neurology, Chongqing General Hospital, University of Chinese Academy of Sciences, Chongqing, Chongqing, China Tibetan Plateau Ethnic Medicinal Resources Protection and Utilization Key Laboratory of National Ethnic Affairs Commission of the People’s Republic of China, Southwest Minzu University, Chengdu 610041, China Alibaba Group, Beijing, China School of Pharmacy; Shenyang Pharmaceutical University; Shenyang China; National and Local United Engineering Laboratory for Key Technology of Chinese Material Medica Quality Control; Shenyang Pharmaceutical University; Shenyang China College of Life Sciences Nanjing Agricultural University Nanjing 210095 China Hemodialysis Room, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu, P.R. China Department of Histology and Embryology, Chongqing Medical University School of Life Sciences Northwestern Polytechnical University Xi'an Shaanxi P.R. China; Center of Special Environmental Biomechanics & Biomedical Engineering Northwestern Polytechnical University Xi'an Shaanxi P.R. China; Key Laboratory on Space Physics and Chemistry of Ministry of Education and Key Laboratory on Macromolecular Science & Technology of Shanxi Province, Department of Applied Chemistry, School of Science Northwestern Polytechnical University Xi'an Shaanxi P.R. China From the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore, MD; and Onconova Therapeutics Inc, Newtown, PA College of pharmacy, Shaanxi University of Chinese Medicine, Xianyang 712046, China Department of Biotherapy, The State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, China. Program in Cellular and Molecular Medicine Boston Children's Hospital Boston MA USA; Department of Biological Chemistry and Molecular Pharmacology Harvard Medical School Boston MA USA Department of Environmental Health, Weifang Medical University, Shandong, China Nephrology Department I, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China Department of Pulmonary and Critical Care Medicine, The First People's Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan, 650000, China; Department of Pulmonary and Critical Care Medicine, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510000, Guangdong, China; The Second School of Clinical Medicine, Southern Medical University, Guangzhou 510000, Guangdong, China Qingdao National Laboratory for Marine Science and Technology, Key Laboratory of Marine Drugs of Minister of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China 6 West China School of Public Health, West China Forth Hospital, Sichuan University Chengdu China Department of Radiology,PUMC Hospital,CAMS and PUMC,Beijing 100730,China. Department of Industrial Engineering, Arizona State University, Tempe, Arizona, USA School of Life and Health Sciences, The Chinese University of Hong Kong, Shenzhen, Longgang District, Shenzhen, Guangdong Province 518172, China; Warshel Institute for Computational Biology, The Chinese University of Hong Kong, Shenzhen, Longgang District, Shenzhen, Guangdong Province 518172, China College of Horticulture, Guangdong Provincial Key Laboratory of Postharvest Science of Fruits and Vegetables, Engineering Research Center for Postharvest Technology of Horticultural Crops in South China, Ministry of Education, South China Agricultural University, Guangzhou 510642, P.R. China Target Validation (J.L., H.H.Z.), Merck Research Laboratories, Rahway, New Jersey 07065 School of Chemistry and Chemical Engineering Anhui Province Key Laboratory of Chemistry for Inorganic/Organic Hybrid Functionalized Materials Institute of Physical Science and Information Technology Anhui University Hefei 230601 P. R. China Minimal Invasive Tumor Therapy Center, Beijing Coal General Hospital, Beijing, China Department of Spine Surgery, The Second Xiangya Hospital, Central South University , Changsha , China College of Food Science and Technology, Huazhong Agricultural University, Wuhan, 430070, China; Key Laboratory of Environment Correlative Dietology (Huazhong Agricultural University), Ministry of Education, China Department of Radiology, the First Medical Centre, Chinese PLA General Hospital, Beijing, China Department of Internal Medicine, Qingdao Medical Care Center for Women and Children, Qingdao, Shandong 266011, China. Pharmaceutical Candidate Optimization, Nonclinical Research and Development, Bristol Myers Squibb Company, Princeton, New Jersey 08540, United States Division of Medicinal Chemistry, College of Pharmacy, The University of Texas at Austin, Texas 78712, United States Advanced Materials Institute Qilu University of Technology Shandong Academy of Sciences) Jinan 250014 P. R. China; Shandong Provincial Key Laboratory of High Strength Lightweight Metallic Materials Advanced Materials Institute Qilu University of Technology Shandong Academy of Sciences) Jinan 250014 P. R. China Guangdong Provincial People's Hospital, Guangzhou 510030, China. Animal Health Supervision Institute of Biyang, Biyang, Henan, China Department of Drug Discovery and Biomedical Sciences, College of Pharmacy, University of South Carolina, Columbia, South Carolina 29208, United States Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, CA 94305, USA. State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai201620, People’s Republic of China Department of Sports & Health, Nanjing Sport Institute, Nanjing 210014, China. lijing197512@163.com Department of Medical Imaging, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China Chongqing Key Laboratory of Chemical Process for Clean Energy and Resource Utilization; School of Chemistry and Chemical Engineering; Chongqing University; Shapingba 174; China State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun People's Republic of China Clinical and Health Sciences, University of South Australia Adelaide 5000 South Australia Australia Blood Research Institute Versiti Wisconsin Milwaukee Wisconsin; Department of Hematology, Fujian Institute of Hematology, Fujian Provincial Key Laboratory of Hematology Fujian Medical University Union Hospital Fuzhou Fujian China College of Life Science Hunan Normal University Changsha 410081 China College of Life Science; Hunan Normal University; Changsha 410081 China Shandong Provincial Engineering and Technical Center of Light Manipulation, School of Physics and Electronics, Shandong Normal University, Jinan, Shandong 250014, People’s Republic of China Guangzhou Institute of Respiratory Diseases, Guangzhou, 510120, China CAS Center for Excellence in Molecular Plant Sciences, Shanghai Center for Plant Stress Biology Chinese Academy of Sciences Shanghai China; University of Chinese Academy of Sciences Beijing China Department of Magnetic Resonance Imaging, Affiliated Hospital of the Medical College of Chinese People's Armed Police Forces, Tianjin 300162, China. Corresponding author: Wei Luqing, Email: luqing-wei@163.com. Department of Urology, Affiliated Cancer Hospital and Institute of Guangzhou Medical University, Guangzhou 510000, China Department of Cardiology, The 924th Hospital of Chinese People’s Liberation Army Joint Service Support Force, Guilin, China. Xianyang Central Blood Bank Xianyang Shaanxi Province China Department of New Drug Evaluation Beijing Institute of Pharmacology and Toxicology Beijing China Department of Medicine, Division of Cardiovascular Disease, The University of Alabama at Birmingham 703 19th St. South, ZRB-302, Birmingham, AL 35233 , USA Key Laboratory of Applied Surface and Colloid Chemistry (Shaanxi Normal University), Ministry of Education and School of Chemistry and Chemical Engineering, Shaanxi Normal University Department of Ophthalmology, Ophthalmology and Optometry Center, Peking University People's Hospital and Beijing Key Laboratory of Diagnosis and Treatment of Retinal and Choroid Diseases, Beijing 100044, China. Department of Ophthalmology, Shaanxi Provincial People's Hospital, Xi'an 710068, Shaanxi Province, China. Cotton Research Institute Shanxi Academy of Agricultural Sciences Yuncheng Shanxi province China College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, People’s Republic of China Key Laboratory of Bioresources and Ecoenvironment (Ministry of Education), College of Life Sciences, Sichuan University, Chengdu, China Department of Endocrinology, Health Management Center, Tianjin Union Medical Center, Nankai University Affiliated Hospital, Tianjin, China Key Laboratory for Molecular Genetic Mechanisms and Intervention Research on High Altitude Disease of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, Shannxi Province, China; Key Laboratory of High Altitude Environment and Genes Related to Diseases of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, Shannxi Province, China Department of Bioinformatics and Biostatistics, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, People’s Republic of China; Shanghai Center for Bioinformation Technology, Shanghai 201203, People’s Republic of China School of Economics Singapore Management University Singapore State Key Laboratory of Plant Physiology and Biochemistry, College of Life Science, Zhejiang University, Hangzhou, 310029, People's Republic of China (X.M., Q. Zhu, X.L., J.L., Q. Zeng, P.W.); and Institute of Integrative and Comparative Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, United Kingdom (H.R., H.Z.) Department of Pediatrics, Beijing Tongren Hospital, Capital Medical University, BeijingChina State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510120, P.R. China 1Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan. College of Pharmacy, Jinan University , Guangzhou, China; Research Center for Marine Drugs, State Key Laboratory of Oncogenes and Related Genes, Department of Pharmacy, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University , Shanghai, China Guangdong Provincial Key Laboratory of Stomatology Department of Preventive Dentistry Hospital of Stomatology Guanghua School of Stomatology Sun Yat‐sen University Guangzhou Guangdong China Guangdong-Hong Kong-Macau Joint Laboratory for Photonic-Thermal-Electrical Energy Materials and Devices, Institute of Applied Physics and Materials Engineering, University of Macau, Avenida da Universidade, Taipa, Macao SAR 999078, People’s Republic of China Department of Pancreatico-Hepatobiliary Surgery, The Second Affiliated Hospital, Army Medical University, PLA, Chongqing, China. Clinical Metabolomics Center, China Pharmaceutical University, Nanjing 211198, P. R. China Rehabilitation Department, Qingdao Mental Health Center, Shandong 266034, PR China 3Beijing Institute of Microbiology and Epidemiology, Beijing, P. R. China State Key Laboratory of Coordination Chemistry; School of Chemistry and Chemical Engineering; Collaborative Innovation Center of Advanced Microstructures; Nanjing University; Nanjing 210023 State Key Laboratory of Heavy Oil Processing, Centre for Bioengineering and Biotechnology, College of Chemical Engineering, China University of Petroleum (East China), Qingdao 266580, China Department of Physiology and Pathophysiology, College of Basic Medical Science, Peking University, Health Science Center, Beijing, 100191, China Ninth People’s Hospital of Chongqing, Beibei District, Chongqing 400715, China Department of Pathology, Dalian Medical University, Dalian, China Department of Material Chemistry, School of Chemistry and Xi’an Key Laboratory of Sustainable Energy Materials Chemistry, Xi’an Jiaotong University, Xi’an 710049, P. R. China State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University Clinical Laboratory, The First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan 610500, P.R. China Department of Hematology, First Hospital of Xi'an Jiaotong University, Xi'an 710061, China. anlj1676@126.com Xuanwu Hospital, Capital University of Medical Science, Beijing 100053, China. Key Laboratory of Bio‐inspired Smart Interfacial Science and Technology of Ministry of Education School of Chemistry Beihang University Beijing 100191 P. R. China Tianjin Centers for Disease Control and Prevention, Tianjin 300011, China. lichangzhen_1@126.com Peking University 302 Clinical Medical School, Beijing, China. Senior Department of Infectious Diseases, The Fifth Medical Center of Chinese PLA General Hospital, National Clinical Research Center for Infectious Diseases, Beijing, China. State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, P. R. China; University of Chinese Academy of Sciences, Beijing, 100049, P. R. China Acupuncture Anesthesia Clinical Research Institute, Shanghai University of TCM, Shanghai 200437, China; Department of Acupuncture and Moxibustion, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of TCM, Shanghai 200437, China. Zhenjiang Entry-exit Inspection Quarantine Bureau; State Key Laboratory of Food Additive and Condiment Testing; Zhenjiang; P. R. China a Key Laboratory of Eco-Environment-Related Polymer Materials of Ministry of Education, Key Laboratory of Polymer Materials of Gansu Province , College of Chemistry & Chemical Engineering, Northwest Normal University , Lanzhou , 730070 , China Department of Gastroenterology and Hepatology, The Fourth Affiliated Hospital of Anhui Medical University Hefei 230032, Anhui, China. College of Life Sciences, Northwest A&F University, Yangling, China 4 Shanghai Henlius Biotech, Inc, Shanghai, Shanghai, China Department of Electrical and Automatic Engineering, School of Information Engineering, Nanchang University, Nanchang 330031, China State Key Laboratory of Electroanalytical Chemistry Changchun Institute of Applied Chemistry, Chinese Academy of Sciences Changchun Jilin 130022 China; University of Chinese Academy of Sciences Beijing 100049 China Department of Radiology, The First Affiliated Hospital of Chongqing Medical University, No. 1 Youyi Road, Yuzhong District, Chongqing 400016, China; Medical Imaging Center, Central Hospital of Shaoyang, Shaoyang 422000, China Jilin Ginseng Academy, Changchun University of Chinese Medicine, Changchun, China College of Marine Life Science, Ocean University of China, 5# Yushan Road, Qingdao 266003, Shandong Province, China School of Perfume and Aroma Technology, Shanghai Institute of Technology, Shanghai 201418, PR China Department of Oncology, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, Hubei, China. School of Acupuncture, Moxibustion and Tuina, Beijing University of Chinese Medicine, Beijing 100029, China School of Pharmacy, Health Science Center Xi'an Jiaotong University Xi'an China School of Pharmaceutical Sciences Sun Yat-sen University Guangzhou 510006 China; Key Laboratory of Preclinical Study for New Drugs of Gansu Province Lanzhou University Lanzhou 730000 China National Chinmedomics Research Center, National TCM Key Laboratory of Serum Pharmacochemistry, Metabolomics Laboratory, Department of Pharmaceutical Analysis, Heilongjiang University of Chinese Medicine, Heping Road 24, Harbin 150040, China Department of Plant Science, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, People's Republic of China Department of Cardiovascular Surgery The First Affiliated Hospital of Xi'an Jiaotong University Xi'an China School of Chemistry and Chemical Engineering Yangzhou University Yangzhou 225012 P. R. China Allergy and Clinical Immunology Department, State Key Laboratory of Respiratory Disease, The First Affiliated Hospital Guangzhou Medical University Guangzhou China Key Laboratory of Molecular Nanostructure and Nanotechnology and Beijing National Laboratory for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences (CAS), Beijing 100190, P. R. China; University of CAS, Beijing 100049, P. R. China Department of Geography and the Environment University of Denver Denver CO USA Key Laboratory of Industrial Microbiology, Ministry of Education, College of Biotechnology, Tianjin University of Science & Technology, Tianjin 300457, China Institute of Quality Standard and Testing Technology for Agro-products, Tianjin Academy of Agricultural Sciences, Tianjin, China Department of Materials Science and Engineering, Southern University of Science and Technology, 1088 Xueyuan Blvd., Nanshan District, Shenzhen, Guangdong 518055, P. R. China Sustainable Energy Laboratory; China University of Geosciences Wuhan; Wuhan; China; Department of Chemistry Department of Biochemistry and Molecular Biology, School of Life Sciences, Anhui Medical University, Hefei, Anhui, China Department of Public Health and General Medicine, School of Integrated Traditional and Western Medicine, Anhui University of Traditional Chinese Medicine, Hefei, Anhui, People's Republic of China. Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy Sciences, Beijing 100190, P. R. China Department of Clinical Laboratory, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524001, Guangdong, China Department of Ophthalmology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China Department of Pharmacology, Basic Medical School, Wuhan University, Wuhan, Hubei 430071, China Department of Allergy and Clinical Immunology State Key Laboratory of Respiratory Disease The First Affiliated Hospital Guangzhou Medical University Guangzhou China Key Laboratory of Applied Surface and Colloid Chemistry, National Ministry of Education, Shaanxi Key Laboratory for Advanced Energy Devices, Shaanxi Engineering Lab for Advanced Energy Technology, School of Materials Science and Engineering, Shaanxi Normal University, Xi’an 710119, China Department of Endocrinology, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou, 450007, China Sinovac Biotech Ltd. Beijing P. R. China Laboratory of Theoretical and Computational Chemistry; Institute of Theoretical Chemistry; College of Chemistry; Jilin University; Changchun Department of Spine Surgery, Second Xiangya Hospital of Central South University, Changsha, China. jingli1969@126.com Laboratory of Applied Surface and Colloids Chemistry Ministry of Education School of Chemistry and Chemical Engineering Shaanxi Normal University Xi'an 710062 P. R. China School of Marine Sciences, Sun Yat-Sen University, Guangzhou 510006, People’s Republic of China State Key Laboratory of Food Nutrition and Safety, Tianjin University of Science & Technology, Tianjin 300457, China Department of Liver Disease, The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen, Guangdong 518033, P.R. China Peter Grünberg Institute(PGI-8), Forschungszentrum Jülich, Jülich 52425, Germany Department of Traditional Chinese Medicine, The Fourth Affiliated Hospital, Hebei Medical University, Shijiazhuang, China. Department of Gastroenterology Peking University First Hospital Beijing China College of Plant Protection Hebei Agricultural University Baoding China Wannan Medical College Department of Ophthalmology, Xinhua Hospital, Shanghai Jiao Tong University, China. li.jing@seri.com.sg Botanical Review Team, Office of Pharmaceutical Quality, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA School of Physics, Harbin Institute of Technology, 150001, Harbin, China Department of Radiology Changhai Hospital, Navy Medical University Shanghai China College of Life Sciences, Capital Normal University, Beijing, P. R. China Shanghai Jiao Tong University Affiliated Sixth People's Hospital South Campus Shanghai University of Medicine & Health Sciences Affiliated Sixth People's Hospital South Campus Southern Medical University Affiliated Fengxian Hospital 6600th Nanfeng Road, Fenxian District Shanghai 201499 China Department of Rheumatology and Immunology, Peking University People’s Hospital, Beijing, China; Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135), Beijing, China State Key Laboratory of Bioreactor Engineering East China University of Science and Technology Shanghai China School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, China Department of Gastroenterology Institute of Organic Chemistry, University of Vienna, Währinger Strasse 38, 1090 Vienna, Austria Tianjin Key Laboratory of Metabolic Diseases, Chu Hsien-I Memorial Hospital, Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin, China School of Materials Science and Engineering; Harbin Institute of Technology; Harbin 150001; China; SP2M Department of Endocrinology, Zhengzhou Central Hospital Affiliated to Zhengzhou University Key Laboratory of State Administration of Traditional Chinese Medicine Sunshine Lake Pharma Co., LTD Dongguan China Department of Biomedical Research, Hackensack University Medical Center, Hackensack, New Jersey Senior Department of Infectious Diseases, The Fifth Medical Center of Chinese PLA General Hospital, National Clinical Research Center for Infectious Diseases, Beijing 100039, China 0000 0001 0708 1323 grid.258151.a The Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology Jiangnan University 214122 Wuxi Jiangsu People’s Republic of China School of Biomedical Sciences The Chinese University of Hong Kong Hong Kong SAR China Department of Radiology Jing'an District Center Hospital of Shanghai Shanghai China Departments of Medicine and Pediatrics Virginia Commonwealth University Richmond Virginia School of Mechanical Engineering and Hubei Modern Manufacturing Quality Engineering Key Laboratory, Hubei University of Technology, Wuhan 430068, China; School of Mechanical and Electrical Engineering, University of Electronic Science and Technology of China, Chengdu 611731, China School of Public Health, Health Science Center, Xi’an Jiaotong University, Xi’an 710061, China Markey Cancer Center, University of Kentucky, Lexington, KY, USA; Department of Surgery, University of Kentucky, Lexington, KY, USA Department of Respiratory Diseases Shenzhen Children’s Hospital Shenzhen China Department of Physiology and Pathophysiology, Peking University Health Science Center, Beijing 100191, China. Department of Pharmacology; Nanomedicine Engineering Laboratory of Jilin Province; College of Basic Medical Sciences; Jilin University; Changchun 130021 From the Leeds Institute of Cardiovascular and Metabolic Medicine, School of Medicine (J.L., A.-F.B., B.H., B.R., P.J.W., M.A.B., H.L.A., N.K.M., J.E.R., N.Y.Y., S.T., M.Q., L.M., H.T., K.E.P., D.J.B.) and School of Chemistry (R.F.), University of Leeds, Leeds, United Kingdom; Departments of Hepatobiliary and Transplant Surgery (K.R.P.) and Colorectal Surgery (D.B.), St. James’s University Hospital, Leeds, United Kingdom; and Yorkshire Heart Centre, Leeds General Infirmary, Leeds, United Kingdom (D... School of Mechanical Engineering, North University of China, Taiyuan 030051, China; Shanxi Provincial Key Laboratory of Advanced Manufacturing Technology, North University of China, Taiyuan 030051, China Department of Pediatrics, University of Chicago, Chicago, Illinois; and the Albert Einstein Cancer Center, Department of Medicine and Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, New York Assisted Reproduction Unit, Department of Obstetrics and Gynecology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310016, China School of Perfume and Aroma Technology, Shanghai Institute of Technology, Shanghai, People’s Republic of China School of Forestry, Central South University of Forestry and Technology, Changsha 410004, China; Key Laboratory of Soil and Water Conservation and Desertification Combating of Hunan Province, Changsha 410004, China National Clinical Research Center for Cardiovascular Diseases Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, National Center for Cardiovascular Diseases Beijing China Xinjiang Institute of Product Quality Supervision and Inspection; Urumqi; 830011 P. R. China State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, China; Graduate School of the Chinese Academy of Sciences, Beijing, 100039, P. R. China Institute of Integrated Traditional Chinese and Western Medicine, Guangzhou Medical University, Guangzhou, China. Hefei Tianmai Biotechnology Development Co. Ltd, Hefei, China Department of Chemistry and Howard Hughes Medical Institute, The University of Chicago, Chicago, Illinois 60637, United States Jilin University Key Laboratory for Supermolecular Structure and Materials of Ministry of Education, , Changchun 130012, People’s Republic of China Xi’an Jiaotong University School of Chemistry Beihang University Beijing 100191 China Department of Materials Science & Engineering, University of Texas at Dallas, Richardson, Texas 75080, United States, Department of Physics and Astronomy, Rutgers University, 610 Taylor Road, Piscataway, New Jersey 08854, United States, and Department of Chemistry and Chemical Biology, Rutgers University, 610 Taylor Road, Piscataway, New Jersey 08854, United States State Key Laboratory of Chemo/Biosensing and Chemometrics; College of Chemistry and Chemical Engineering, Key Laboratory for Bio-Nanotechnology and Molecular Engineering of Hunan Province; Hunan University; Changsha; China Department of Stomatology, China-Japan Friendship Hospital, Beijing, China Department of Bioinformatics & Biostatistics, School of Life Science and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China; Shanghai Center for Bioinformation Technology, Shanghai 201203, China Department of Ophthalmology, Eye Institute, Eye and ENT Hospital, Fudan University, Shanghai 201114, China Department of Obstetrics and Gynecology (A.D., J.L., A.J.W.H.), Division of Reproductive Biology, Stanford University School of Medicine, Stanford, California 94305-5317 Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL 1 College of Life Science and Technology, Beijing University of Chemical Technology, Beijing, China Department of Respiratory & Critical Care Medicine, Southern Medical University, Guangzhou, China. Department of Nephrology, Affiliated Hospital of Jiangsu University, Zhenjiang, China. College of Ecological Environment, Tibet University, 10 East Zangda Road, Lhasa 850000, China Center for Neurological Function Test and Neuromodulation , West China Xiamen Hospital, , 699 Jinyuan West Road, Xingbin Street, Jimei District, Xiamen, Fujian 361021 , China; Sichuan University , West China Xiamen Hospital, , 699 Jinyuan West Road, Xingbin Street, Jimei District, Xiamen, Fujian 361021 , China State Key Laboratory of Bioelectronics, Jiangsu Key Laboratory for Biomaterials and Devices, School of Biological Sciences and Medical Engineering, Southeast University, Nanjing 210096, P. R. China School of Kinesiology, Shenyang Sport University, Shenyang, China Department of Tumor Minimally Invasive Treatment, The Fifth Medical Center, Chinese PLA General Hospital, Beijing, People's Republic of China School of Mechanical Engineering, Jiangsu University, Zhenjiang 212013, China; School of Electronic Information and Electrical Engineering, Anyang Institute of Technology, Anyang 455000, China Department of Radiology, Changhai Hospital of Shanghai, Second Military Medical University, Shanghai, China Division of Nephrology, Hypertension and Renal Transplantation, Department of Physiology and Functional Genomics, University of Florida College of Medicine, Gainesville, FL 32610, U.S.A. Department of Biochemistry and Molecular Biology, Beijing Key Laboratory, Beijing Normal University, Beijing 10087, People’s Republic of China grid.458488.d 0000000406271442 CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences 100101 Beijing China; Beijing Key Laboratory of Microbial Drug Resistance and Resistome 100101 Beijing China West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu 610065, China State Key Laboratory for Protein and Plant Gene Research, Peking‐Tsinghua Center for Life Sciences at College of Life Sciences Peking University Beijing 100871 China; Beijing Advanced Innovation Center for Tree Breeding by Molecular Design, College of Bioscience and Resources Environment Beijing University of Agriculture Beijing 102206 China Department of Hepatobiliary Surgery, Xinqiao Hospital, PLA Third Military Medical University, Chongqing, China. Tsinghua-Peking Joint Centers for Life Sciences; School of Pharmaceutical Sciences; Tsinghua University; Beijing 100084; China Coordination Chemistry Institute, State Key Laboratory of Coordination Chemistry, Nanjing University, Nanjing 210093, P. R. China School of Chemistry and Chemical Engineering Key Laboratory for Macromolecular Science of Shaanxi Province Shaanxi Normal University Xi'an 710119 P. R. China National Engineering Research Center of JUNCAO Technology, Fujian Agriculture and orestry University, Fujian, Fuzhou 350002, PR China. Department of Neurology The Affiliated Tumor Hospital of Guangxi Medical University Nanning China Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, P. R. China 116023 State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Beijing Key Laboratory of Drug Targets Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China. Institute of Cotton Research Shanxi Academy of Agricultural Sciences Yuncheng Shanxi 044000 China Process Chemistry, Merck & Co., Inc., West Point Pennsylvania 19486, United States Department of Tropical Medicine, College of Preventive Medicine, Third Military Medical University, Chongqing, China; Department of Preventive Healthcare, Yan’an Hospital affiliated to Kunming Medical, Kunming, China The State Key Laboratory of Power Transmission Equipment & System Security and New Technology, Chongqing Key Laboratory of Chemical Process for Clean Energy and Resource Utilization, School of Chemistry and Chemical Engineering, Chongqing University, Shazhengjie 174, Chongqing 400044, China The Third Medicine Department, Anyang Cancer Hospital, Anyang, Henan 455000, P.R. China Qilu Hospital, Shandong University, Jinan, Shandong, China; The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Qilu Hospital of Shandong University, Jinan, Shandong, China Department of Hematology and HCT, Hematologic Malignancies Research Institute, City of Hope National Medical Center, Duarte, CA 91010, USA School of Environmental Science and Engineering, Changzhou University, Jiangsu, 213164, China; Advanced Plasma Catalysis Engineering Laboratory for China Petrochemical Industry, Changzhou University, Jiangsu, 213164, China Department of Respiratory and Critical Care Medicine Nanfang Hospital Southern Medical University Guangzhou China Jiangsu Key Laboratory for NSLSCS, School of Physical Science and Technology, Nanjing Normal University, Wenyuan Road 1, Nanjing 210023, P. R. China; State Key Laboratory of Coordination Chemistry, Collaborative Innovation Center of Advanced Mirostructures, School of Chemistry and Chemical Engineering, Nanjing University, Xianlin Road 163, Nanjing 210023, P. R. China School of Materials and Energy, Center for Applied Chemistry, University of Electronic Science and Technology of China, Chengdu 611731, P. R. China Jiangsu Key Laboratory of Immunity and Metabolism, Department of Pathogenic Biology and Immunology, Xuzhou Key Laboratory of Infection and Immunity, Xuzhou Medical University, Xuzhou 221004, People’s Republic of China; School of Management, University of Science and Technology of China , Hefei, Anhui, China; Department of Research and Development, Shenzhen Byoryn Technology Co., Ltd. , Shenzhen, China School of Microelectronics Dalian University of Technology No.2 Linggong Road Dalian 116024 China Department of Rheumatology and Immunology Peking University People's Hospital Beijing 100044 China; Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135) Beijing 100044 China Department of Pharmaceutical Sciences University of the Sciences in Philadelphia Philadelphia Pennsylvania USA School of Environment, Key Laboratory for Yellow River and Huai River Water Environment and Pollution Control, Ministry of Education, Henan Normal University, Xinxiang 453007, China State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center; Université Côte d’Azur, CNRS, INSERM, IRCAN Department of Ophthalmology The First Affiliated Hospital of Fujian Medical University Fuzhou China Department of Cardiology, Gaoyou Hospital of Traditional Chinese Medicine, Yangzhou 225600, China National & Local United Engineering Laboratory of Integrative Utilization Technology of Eucommia Ulmoides, College of Hunan Province, Jishou University, Jishou 416000, P. R. China; College of Biological Resources and Environmental Sciences, College of Hunan Province, Jishou University, Jishou 416000, P. R. China; Key Laboratory of Plant Resources Conservation and Utilization, College of Hunan Province, Jishou University, Jishou 416000, P. R. China Department of Otorhinolaryngology Head and Neck Surgery, Hangzhou First People’s Hospital, Nanjing Medical University Shandong Provincial Key Laboratory of Chemical Energy Storage and Novel Cell Technology, College of Chemistry and Chemical Engineering, Liaocheng University, Liaocheng, Shandong 252059, China State Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, 190 Kaiyuan Avenue, Guangzhou 510530, P. R. China, and Department of Chemistry, Jinan University, Huangpu Road West 601, Guangzhou 510632, P. R. China School of Chemistry and Chemical Engineering Chongqing University Shazhengjie 174 Chongqing 400044 China Department of Bioinformatics and Biostatistics, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, People's Republic of China Key Laboratory of Human Disease Comparative Medicine National Health Commission of China (NHC) Institute of Laboratory Animal Science Peking Union Medicine College Chinese Academy of Medical Sciences Beijing China; Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases Institute of Laboratory Animal Science Peking Union Medicine College Chinese Academy of Medical Sciences Beijing China Taizhou Mabtech Pharmaceuticals Co., Ltd Jiangsu China Department of Immunology, College of Basic Medical Sciences, Jilin University, Changchun, Jilin 130021, P.R. China Department of Neurology, Donggang Central Hospital, Donggang, China The Molecular Biology Laboratory; Mental Health Center, Zhejiang University School of Medicine NHC Key Laboratory of Hormones and Development (Tianjin Medical University), Tianjin Key Laboratory of Metabolic Diseases, Tianjin Medical University Chu Hsien-I Memorial Hospital and Tianjin Institute of Endocrinology, Tianjin, China Chinese Academy of Medical Sciences, Key Laboratory of Virus Vaccine Research & Development System Innovation, Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming 650031, China; Key Laboratory of Systemic Innovative Research on Virus Vaccine, Chinese Academy of Medical Sciences, Kunming 650031, China Henan Engineering Research Center of Design and Recycle for Advanced Electrochemical Energy Storage Materials School of Materials Science and Engineering Henan Normal University Xinxiang 453007 P. R. China; Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals Key Laboratory of Green Chemical Media and Reactions Ministry of Education School of Chemistry and Chemical Engineering Henan Normal University Xinxiang 453007 P. R. China Department of Civil Engineering, McGill University, Montreal, Canada H3A 2K6 Department of Respiratory and Critical Care Medicine, Shandong Provincial Chest Hospital Affiliated to Shandong University, Jinan, Shandong 250013, P.R. China Department of Obstetrics and Gynaecology and BC Children's Hospital Research Institute University of British Columbia Vancouver British Columbia Canada Second Department of Respiratory Medicine, Shanxi Provincial Cancer Hospital, TaiYuan, ShanXi, P.R. China 3 Lingnan Medical Research Centre, School of Medicine, Guangzhou University of Chinese Medicine, Guangzhou, People's Republic of China Engineering Research Centre of Molecular Medicine of Ministry of Education, Key Laboratory of Fujian Molecular Medicine, Key Laboratory of Precision Medicine and Molecular Diagnosis of Fujian Universities, Key Laboratory of Xiamen Marine and Gene Drugs, School of Medicine, Huaqiao University, Quanzhou 361020, China Maternal and Child Health Center of Changsha; Hunan China Division of Medicinal Chemistry, College of Pharmacy, The University of Texas at Austin, Austin, Texas 78712 Department of Sports and Health, Nanjing Sport Institute, Nanjing, Jiangsu Province, China; Nanjing Integrated Traditional Chinese and Western Medicine Hospital, Nanjing, Jiangsu Province, China; Wilson Centre, University of Toronto, Toronto, Ontario, Canada State Key Laboratory of Marine Resource Utilization in South China Sea Hainan Provincial Key Lab of Fine Chemistry School of Science Hainan University Haikou 570228 China Center for Applied and Environmental Microbiology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, People’s Republic of China; Graduate School of the Chinese Academy of Sciences, Beijing 100039, People’s Republic of China Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health The National Clinical Research Center for Metabolic Diseases of Ministry of Health Rui‐Jin Hospital Shanghai Jiao‐Tong University School of Medicine E‐Institute of Shanghai Universities Shanghai China; Shanghai Clinical Center for Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic Diseases Department of Endocrine and Metabolic Diseases Rui‐Jin Hospital Shanghai Jiao‐Tong University School of Medicine Shanghai China Division of Cardiology, Xuanwu Hospital Capital Medical University Department of Histology and Embryology, North Sichuan Medical College, Nanchong City, China; Institute of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China Laboratory of Electron Microscopy North Sichuan Medical College Nanchong 637007 People's Republic of China; Department of Histology and Embryology North Sichuan Medical College Nanchong 637007 People's Republic of China Department of Otolaryngology People's Hospital of Henan Province Zhengzhou China College of Basic Medical Sciences, Heilongjiang Academy of Medical Sciences, Harbin Medical University, Harbin 150081, China Anhui Medical University, Hefei, China. Tianjin Key Laboratory of Molecular Optoelectronic, Department of Chemistry, Tianjin University, Tianjin 300072, People’s Republic of China Institute for Soil and Water Resources and Environment, Zhejiang University, Hangzhou 310029, China. State Key Laboratory of Animal Nutrition Institute of Animal Sciences of Chinese Academy of Agricultural Sciences Beijing 100193 China; Scientific Observing and Experiment Station of Animal Genetic Resources and Nutrition in North China of Ministry of Agriculture and Rural Affairs Institute of Animal Sciences of Chinese Academy of Agricultural Sciences Beijing 100193 China Department of Geriatrics, the First Affiliated Hospital of China Medical University, Shenyang, China Department of Gynecology and Obstetric, Tongji hospital, Tongji Medical College, Huazhong versity of Science and Technology University, Wuhan 430030, China. Key Laboratory of Industrial Microbiology, Ministry of Education; College of Biotechnology, Tianjin University of Science and Technology; Tianjin 300457 China Institute of Cardiovascular Sciences, Peking University Health Science Center, Beijing 100191, China; Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Beijing, China Department of cardiology, The seventh people’S hospital of Zhengzhou, Zhengzhou City, Henan Province, PR. China Postdoctoral Research Station, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China; Lingnan Medical Research Center, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China; Integrative Cancer Centre, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China Hubei Provincial Hospital of Traditional Chinese Medicine, Wuhan 430000, China Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas Beijing Advanced Innovation Center for Soft Matter Science and Engineering, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing, P. R. People’s Republic of China Department of Radiology and Nuclear Medicine Xuanwu Hospital, Capital Medical University No. 45 Changchun Street, Xicheng District Beijing China; Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics Beijing China People’s Hospital of Hunan Province, First Affiliated Hospital of Hunan Normal University, Changsha, China Department of Food and Nutrition and Korean Institute of Nutrition, Hallym University, 39 Hallymdaehak-gil, Chuncheon, Kangwon 200-702, Korea. Department of Cardiology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China Clinical and Regulatory Department, Hutchison MediPharma Limited, Shanghai, China Department of Pediatrics, Beijing Chang Ping Hospital of Integrated Chinese and Western Medicine, Beijing 100096, China. Nephrology Department Hospital of Chengdu University of Traditional Chinese Medicine Chengdu 610072 China Department of Nutrition Sciences and the Clinical Nutrition Research Center, University of Alabama at Birmingham, Birmingham, Alabama, USA College of Food Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China Division of Sleep Medicine Peking University People's Hospital Beijing China College of Chemistry; Sichuan University; Chengdu 610064; P. R. China Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Beijing 100730, China Department of Ophthalmology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 1665 Kong Jiang Road, Shanghai 200092, China Department of Radiology Brigham and Women's Hospital, Harvard Medical School Boston MA USA; Department of Radiology The Affiliated Hospital of Zhengzhou University (Henan Cancer Hospital) Zhengzhou Henan China Department of Mechanical Engineering City University of Hong Kong Hong Kong China Department of Environmental Health, School of Public Health, China Medical University, Shenyang 11001, People's Republic of china Department of Integrated Traditional Chinese and Western Medicine, Tongji Hospital School of Stomatology Peking University Beijing China Weldon School of Biomedical Engineering, Purdue University, 206 S. Martin Jischke Drive, West Lafayette, IN 47907 School of Biology, Georgia Institute of Technology, Atlanta, Georgia 30332-0230, and Department of Ophthalmology, Emory Eye Center, Emory University School of Medicine, Atlanta, Georgia 30322 Shenyang National Laboratory for Materials Science (SYNL), Institute of Metal Research (IMR), Chinese Academy of Sciences (CAS), No. 72 Wenhua Road, Shenyang 110016, China Guangzhou Tianpeng Technology Co., Ltd., Guangzhou, People’s Republic of China Department of Spine Surgery, The Second Xiangya Hospital, Central South University, Changsha, China Department of Biochemistry and Molecular Biology, Harbin Medical University, Harbin, P.R. China Department of Traditional Chinese Medicine, General Hospital of Guangzhou Military Command of PLA, Guangzhou 510010, China College of Pharmaceutical Science Zhejiang University of Technology Hangzhou P. R. China Scientific Research Center; China-Japan Union Hospital of Jilin University; Changchun; China Department of Chemistry, Tsinghua University, Beijing 100084, China Department of Gynecological Oncology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, Guangdong Province, China Department of Urology, Changhai Hospital, Shanghai, China. State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China. Key Laboratory for Polymeric Composite and Functional Materials of Ministry of Education, Key Laboratory of High Performance Polymer-based Composites of Guangdong Province, School of Chemistry, Sun Yat-sen University, Guangzhou 510275, People’s Republic of China Department of Anesthesia Zunyi Medical University Zunyi Guizhou China Department of Bioinformatics, Key Laboratory of Ministry of Education for Gastrointestinal Cancer, The School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China College of Food Science and Engineering, Ocean University of China, Qingdao, China Electrical Engineering and Computer Science Department, Case Western Reserve University, Cleveland, Ohio. College of Chemistry and Biology Engineering, Yancheng Institute of Technology, 9 Yingbin Avenue, Yancheng 224051, P. R. China Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, California 92121 Department of Environmental Health, School of Public Health China Medical University Shenyang China Department of Obstetrics and Gynecology, Qilu Hospital of Shandong University, Jinan, China The Institute for Advanced Studies (IAS) Wuhan University Wuhan 430072 P. R. China Pediatric Intensive Care Unit, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230032, China. sunjingmin8@qq.com. Department of Orthopaedics, Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, China.; Department of Orthopaedics, Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, China. Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China; State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Beijing, China; National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Ministry of Science & Technology, Beijing, China Department of Evidence‐Based Medicine and Clinical Epidemiology, West China Hospital Sichuan University Chengdu China Department of Epidemiology and Biostatistics, School of Public Health, Guangdong Pharmaceutical University, Haizhu District, Guangzhou Cancer Institute of Integrated Tradition Chinese and Western Medicine, Zhejiang Academy of Traditional Chinese Medicine, Tongde Hospital of Zhejiang Province, Hangzhou, Zhejiang 310012, China Department of Food and Nutrition, Korean Institute of Nutrition, and Department of Chemistry, Hallym University, Chuncheon, Republic of Korea, and School of Biotechnology, Kangwon National University, Chuncheon, Republic of Korea Reproductive Medical Center, The Sixth Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China Department of Orthopaedics, the First Affiliated Hospital of Wenzhou Medical College, Wenzhou 325000, Zhejiang, China. lijing0577@163.com Key Laboratory of Southwestern Chinese Medicine Resources, Key Laboratory of standardization of Chinese herbal medicine of MOE, Chengdu University of Traditional Chinese Medicine , Chengdu , PR China From the University of Wisconsin, Madison, WI; and the Mayo Clinic, Rochester, MN School of Materials Science and Engineering; Zhejiang University; Hangzhou 310027; P. R. China College of Chemistry and Molecular Engineering; School of Life Sciences; Zhengzhou University; Zhengzhou 450001; People's Republic of China Department of Pediatrics, Santa Barbara Cottage Hospital, Santa Barbara, Calif. Department of acupuncture and moxibustion, Weifang Hospital of Traditional Chinese Medicine, Weifang, Shandong, China. Key Laboratory of Biomass Chemical Engineering of Ministry of Education College of Chemical and Biological Engineering Zhejiang University Hangzhou 310027 China Department of Pharmacology and Department of Cardiology, Gansu Provincial Hospital, Lanzhou, Gansu 730000, P.R. China Science College, Linyi University, Linyi, Shandong 276005, China Department of Hepatobiliary Surgery The 958th Hospital of the PLA Army Chongqing China College of Life Science and Biotechnology, Heilongjiang Bayi Agricultural University, Daqing, Heilongjiang 163319, P.R. China Department of Nephrology, The First Affiliated Hospital of Xinjiang Medical University, Ürümqi, China National Clinical Research Center of Cardiovascular Diseases, Fuwai Hospital, Beijing, China; National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China Medical School of Nantong University Nantong 226001 China; Cancer Research Center Nantong Tumor Hospital & Affiliated Tumor Hospital of Nantong University Nantong 226001 China Key Laboratory for Polymeric Composite and Functional Materials of Ministry of Education, School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, China Antibiotics Research and Re-evaluation Key Laboratory of Sichuan Province, Sichuan Industrial Institute of Antibiotics, Chengdu University, Chengdu 610052, Sichuan, China Department of Radiation Protection Medicine, Ministry of Education Key Laboratory of Hazard Assessment and Control in Special Operational Environment, Faculty of Preventive Medicine, Air Force Medical University, Xi’an City, Shannxi Province, China Zai Lab (Shanghai) Co., Ltd. Shanghai China Department of Pharmacy, the Affiliated Hospital of Qingdao University, Qingdao, China Research Center for Marine Drugs, State Key Laboratory of Oncogenes and Related Genes, Department of Pharmacy, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China; College of Pharmacy, Jinan University, Guangzhou 510632, China Department of Genetics and Biochemistry, Clemson University, 190 Collings Street, Clemson, SC 29634, U.S.A. Key Laboratory of Green and Precise Synthetic Chemistry and Applications, Ministry of Education, Anhui Province Key Laboratory of Pollutant Sensitive Materials and Environmental Remediation, College of Chemistry and Material Science, Huaibei Normal University, Huaibei, 235000, People's Republic of China Division of Rheumatology, School of Medicine, University of California, San Francisco State Key Laboratory of Coordination Chemistry; Collaborative Innovation Center of Advanced Microstructures; School of Chemistry and Chemical Engineering; Nanjing University; Nanjing 210093 School of Food Science and Technology, Jiangnan University, 1800 Lihu Avenue, Wuxi, Jiangsu 214122, China School of Mechanical Engineering, Yangzhou University, Yangzhou 225127, China; JITRI Institute of Precision Manufacturing, Nanjing 211800, China Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Jiangsu, China Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, New Jersey 08854 School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, China; The Modernization Engineering Technology Research Center of Ethnic Minority Medicine of Hubei Province, School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, China College of chemistry and material science, Hebei Normal University, Shijiazhuang, 050016, China Division of Cardiology, Hospital for Sick Children, University of Toronto, Canada Department of Orthopedics, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China Department of Surgery,; Lucille P. Markey Cancer Center, University of Kentucky, Lexington, Kentucky; Peking University Hospital of Stomatology. College of Pharmacy, Southwest Minzu University, Chengdu, Sichuan, People’s Republic of China; NHC Key Laboratory of Hormones and Development, Tianjin Key Laboratory of Metabolic Diseases, Chu Hsien-I Memorial Hospital & Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin 300134, China Center for Molecular Metabolism, Nanjing University of Science and Technology, 200 Xiaolingwei Street, Nanjing 210094, China Department of Osteoarthritis Luoyang Orthopedics Hospital of Henan Province Luoyang P.R. China Breast Surgery Ward, Department of General Surgery, Fujian Medical University Union Hospital, Fuzhou, Fujian Province, China Hematology Center, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China; Beijing Key Laboratory of Pediatric Hematology Oncology, Beijing, China; National Key Clinical Discipline of Pediatric Hematology, National Key Discipline of Pediatrics (Capital Medical University), Beijing, China; Key Laboratory of Major Diseases in Children, Ministry of Education, Beijing, China Authors' Affiliations: Departments of 1Biochemistry and Molecular Genetics, 2Biopharmaceutical Sciences, and 3Pathology, University of Illinois at Chicago; and 4Research & Development Section, Jesse Brown VA Medical Center, Chicago, Illinois The Key Laboratory of Fuel Cell Technology of Guangdong Province & The Key Laboratory of New Energy Technology of Guangdong Universities, School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510641, China State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing, 100193, P. R. China Department of Gastroenterology, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, Liaoning�121001, P.R. China Xijing Hospital, The Air Force Military Medical University, Xi’an 710000, China Department of Orthopaedic Oncology, Xijing Hospital Affiliated to the Fourth Military Medical University, Xi'an, China. Division of Nephrology, Affiliated Hospital of Hebei University, No. 212 of Yuhua East Road, Lianchi District, Baoding, Hebei 071000, China; College of Clinical Medicine, Hebei University, Baoding, China; Key Laboratory of Bone Metabolism and Physiology in Chronic Kidney Disease of Hebei Province, No. 212 of Yuhua East Road, Lianchi District, Baoding, Hebei 071000, China Department of Ophthalmology, Huizhou Municipal Central Hospital, Huizhou, Guangdong 516001, P.R. China Howard Hughes Medical Institute and Departments of Pathology and Laboratory Medicine and Pediatrics, University of California, Los Angeles, CA 90095; Genomics Institute of the Novartis Research Foundation, San Diego, CA 92121; Howard Hughes Medical Institute, Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390; and Nuclear Receptor Discovery Research, GlaxoSmithKline, Research Triangle Park, NC 27709 Department of Preventive Healthcare, Zhongshan Community Health Service Center , Songjiang District, Shanghai 201600 , China School of Chemistry and Biochemistry and Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, 901 Atlantic Drive, Atlanta, Georgia 30332 Pingdingshan Industrial College of Technology Institute of international communication Pingdingshan 467000 People's Republic of China Department of Rheumatology and Immunology, Beijing Key Laboratory for Rheumatism and Immune Diagnosis, Peking University People’s Hospital, Beijing, China Department of Neonatology Shanghai Children’s Medical Center School of Medicine Shanghai Jiao Tong University Shanghai China From the Department of Physiology and Functional Genomics, College of Medicine (R.K.S., A.C.O., M.M.K., J.L., G.O.L., V.P.A., A.D.d.K., E.M.R., M.K.R.) Department of Diabetes, Endocrinology and Metabolism, Beckman Research Institute, City of Hope, Duarte, CA. National Clinical Research Center for Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College 167 Beilishi Road Beijing 100037 People's Republic of China; Fuwai Hospital Chinese Academy of Medical Sciences 12 Langshan Road, Nanshan District Shenzhen China State Key Laboratory of Materials-Oriented Chemical Engineering; College of Chemical Engineering; Nanjing Tech University; Nanjing; China State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Key Laboratory for Bio-Nanotechnology and Molecular Engineering of Hunan Province, Hunan University, Changsha, P.R. China; School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou, P.R. China Beijing Engineering Research Center for Experimental Animal Models of Human Diseases, Institute of Laboratory Animal Science, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100021, P.R. China Chongqing Institute of Green and Intelligent Technology; Chinese Academy of Sciences; Chongqing 400714; China Key Laboratory of Cultivation and Protection for Non-Wood Forest Trees of Ministry of Education Central South University of Forestry and Technology Changsha 410004 P. R. China; Key Laboratory of Non-Wood Forest Products of State Forestry Administration Central South University of Forestry and Technology Changsha 410004 P. R. China East China Normal UniversityJoint Center for Translational Medicine Shanghai Fengxian District Central Hospital Shanghai China Department of Medical Engineering, Kunming General Hospital, Kunming 650032, China. li_jingkm@126.com Department of Bioengineering, Rice University, Houston, Texas 77005, United States National Clinical Research Center for Cardiovascular Diseases, NHC Key Laboratory of Clinical Research for Cardiovascular Medications, State Key Laboratory of Cardiovascular Disease Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, National Center for Cardiovascular Diseases Beijing China; Fuwai Hospital Chinese Academy of Medical Sciences Shenzhen China Department of Clinical Laboratory, Hunan Provincial People's Hospital The First Affiliated Hospital of Hunan Normal University Changsha China College of Chemistry; Sichuan University; Chengdu 610064; China State Key Laboratory of Elemento-Organic Chemistry; the College of Chemistry; Nankai University; Nankai District; China The Second Xiangya Hospital, Central South University, Changsha, China Department of Clinical Pharmacology Zhongshan Hospital Fudan University Shanghai China State Key Laboratory of Silicon Materials, School of Materials Science and Engineering, Zhejiang University, Hangzhou, Zhejiang 310027, P. R. China Shandong Provincial Key Laboratory of Chemical Energy Storage and Novel Cell Technology, College of Chemistry and Chemical Engineering, Liaocheng University, Liaocheng, Shandong 252059, P. R. China State Key Laboratory of Oncogenes and Related Genes Shanghai Cancer Institute Renji Hospital Shanghai Jiao Tong University School of Medicine China Department of Histology and Embryology, North Sichuan Medical College Nanchong 637000, Sichuan, China. Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming 650118, China School of Food and Biological Engineering, Henan University of Animal Husbandry and Economy, Zhengzhou 450046, China Department of Radiation Oncology The Fourth Hospital of Hebei Medical University Shijiazhuang China School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225002, China Authors' Affiliations: Departments of 1Pathology and Laboratory Medicine, 2Structural and Cellular Biology, and 3Urology, and 4Tulane Cancer Center, Tulane University School of Medicine, New Orleans, Louisiana; 5Department of Pharmacology, Norman Bethune School of Medicine, and 6Edmond H. Fischer Signal Transduction Laboratory, College of Life Sciences, Jilin University, Changchun, China; Authors' Affiliations: Departments of 1Pathology and Laboratory Medicine, 2Structural and Cellular Biology, and 3Urology, and 4Tulane Cancer Center, Tulane University School of Medicine, New Orleans, Louisiana; 5Department of Pharmacology, Norman Bethune School of Medicine, and 6Edmond H. Fischer Signal Transduction Laboratory, College of Life Sciences, Jilin University, Changchun, China; Authors' Affiliations: Departments of 1Pathology and Laboratory Medicine, 2Structural and Cellular Biology, and 3Urology, and 4Tulane Cancer Center, Tulane University School of Medicine, New Orleans, Louisiana; 5Department of Pharmacology, Norman Bethune School of Medicine, and 6Edmond H. Fischer Signal Transduction Laboratory, College of Life Sciences, Jilin University, Changchun, China Department of Pediatric Respirology & Immunology Xinhua Hospital, Shanghai Jiaotong University School of Medicine, 1665 Kongjiang Road Shanghai 200092 China College of Horticulture, Gansu Agricultural University, Yingmen Village, Anning District, Lanzhou 730070, China Université Côte d’Azur, CNRS, Inserm, IRCAN, Nice, France Laboratory of Molecular Recognition and Synthesis, Department of Chemistry, Zhejiang University, Hangzhou 310027, Zhejiang, People’s Republic of China State Key Laboratory of Coordination Chemistry; School of Chemistry and Chemical Engineering; Nanjing University; Nanjing 210023; P. R. China College of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, PR China, 2 Department of Biochemistry and Molecular Biology, Harbin Medical University, Harbin 150081, PR China and 3 Key Laboratory of Cardiovascular Medicine Research, Harbin Medical University, Ministry of Education, PR China From the Department of Cardiology, General Hospital of Shenyang Military Region, Shenyang, China (Y.H., K.X., Q.J., J.L.); Catheterization Laboratory, Fu Wai Hospital, National Center for Cardiovascular Diseases, Beijing, China (B.X., C.G.); Department of Cardiology, Fu Wai Hospital, National Center for Cardiovascular Diseases, Beijing, China (Y.Y.); Department of Cardiology, Affiliated Tangdu Hospital of the Fourth Military Medical University, Xi’an, China (Q.Z.); Department of Cardiology, Fourth... Department of Gastroenterology Beijing Friendship Hospital Capital Medical University National Clinical Research Center for Digestive Diseases Beijing Digestive Disease Center Beijing Key Laboratory for Precancerous Lesion of Digestive Diseases Beijing 100050 China Department of Pathology, Harbin Medical University, Harbin, China Department of Pharmacology, University of Illinois College of Medicine, Chicago (J.L., K.K., S.-Y.J, B.X., X. Du, J. Cho). School of Physics and Physical Engineering, Qufu Normal University, 273165, Qufu, China Key Laboratory for Agricultural Bioengineering of Guizhou Province, China. State Key Laboratory of Oral Diseases National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management West China Hospital of Stomatology Sichuan University Chengdu China National Clinical Research Center for Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China School of Chemistry and Chemical Engineering, Chongqing University, Daxuecheng South Road 55, Chongqing 401331, China Department of Pharmacy The Comparative Health Outcomes Policy, and Economics (CHOICE) Institute, University of Washington Seattle Washington USA Department of Internal Medicine, Center for Health Services Research (CHSR), University of Kentucky, Lexington, KY Key Laboratory of Marine Drugs, Chinese Ministry of Education; School of Medicine and Pharmacy, Ocean University of China, 5 Yushan Road, Qingdao, Shandong 26003, People’s Republic of China Department of Acupuncture and Moxibustion, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Shanghai University of TCM. Department of Genetics and Biochemistry Clemson University SC USA CAS Key Laboratory of Receptor Research, National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 189 Guo Shou Jing Road, Shanghai 201203, China National Center for STD Control, Chinese Academy of Medical Sciences and Peiking Union Medical College, Institute of Dermatology, Nanjing, China Teaching and Research Division, Tianjin Medical College, Tianjin 300000, P.R. China Department of Mechanical and Biomedical Engineering, City University of Hong Kong, Hong Kong, China Heart Center & Beijing Key Laboratory of Hypertension, Beijing Chaoyang Hospital Capital Medical University Beijing China College of Food Science and Engineering; Northwest A&F University; Yangling 712100; PR China Institute of Basic Medical Sciences & School of Basic Medicine, Center of Excellence in Tissue Engineering, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, P.R. China. Department of Radiation Oncology The University of Texas MD Anderson Cancer Center Houston TX USA Department of Immunology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, PR China; National Clinical Research Center for Cancer, Tianjin, PR China; Tianjin Key Laboratory of Cancer Immunology and Biotherapy, Tianjin, PR China CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China The Comparative Health Outcomes, Policy and Economics (CHOICE) Institute, Department of Pharmacy, University of Washington, Seattle, WA, USA Department of Children's Health Care The First Affiliated Hospital of Nanjing Medical University Nanjing China College of Mechanical Engineering, Guangxi University, Nanning 530004, China Department of Laboratory Medicine & Central Laboratory Southern Medical University Affiliated Fengxian Hospital Shanghai 201499 China; Joint Research Center for Precision Medicine Shanghai Jiao Tong University & Affiliated Sixth People's Hospital South Campus Shanghai 201499 China Department of Radiation Oncology, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, China. Division of Cardiovascular Diseases, Department of Medicine Mayo Clinic Rochester Minnesota Institute of Fundamental and Frontier Sciences, University of Electronic Science and Technology of China, Chengdu610054, China School of Chemistry and Chemical Engineering, Liaoning Normal University, Dalian 116029, P. R. China Institute of Medical Biology Chinese Academy of Medical Sciences Peking Union Medical College Yunnan Key Laboratory of Vaccine Research Development on Severe Infectious Disease Kunming 650118 China Department of Traditional Chinese Medicine, Children' Hospital of Kaifeng, Henan province, 4750000,?China. Shanghai Center for Plant Stress Biology, Center for Excellence in Molecular Plant Sciences, Chinese Academy of Sciences , Shanghai 200032, China; University of Chinese Academy of Sciences , Beijing 100049, China Department of Clinical Laboratory Center, Lanzhou University Second Hospital, Lanzhou, Gansu, China School of Materials Science and Engineering, Zhengzhou University, Zhengzhou 450001, People's Republic of China Department of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan , China Department of Medicinal Chemistry, School of Pharmacy, Chongqing Medical University, Chongqing, China Zhejiang Haichang Biotechnology Co., Ltd. Hangzhou Zhejiang 310000 P. R. China Department of Cardiology, 2th Affiliated Hospital of Dalian Medical University, Zhongshan Road No. 467, Dalian 116000, P.R. China School of Automation, Hangzhou Dianzi University, Hangzhou 310018, China; Key Laboratory of Brain Machine Collaborative Intelligence of Zhejiang Province, Hangzhou 310018, China Key Laboratory of Genetics and Biotechnology, College of Life Science, Capital Normal University, 100048 Beijing, China Department of Applied Chemistry, China Agricultural University, Beijing, China The State Key Laboratory of Power Transmission Equipment & System Security and New Technology; Chongqing Key Laboratory of Chemical Process for Clean Energy and Resource Utilization; School of Chemistry and Chemical Engineering; Chongqing University; Shazhengjie 174 Medical record room, Zhejiang Provincial Hospital, Hangzhou, Zhejiang, China R & D Center, Beijing Orbiepharm Co., Ltd., Beijing, People’s Republic of China Division of Materials for Special Environments, Key Laboratory of Nuclear Materials and Safety Assessment, Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110016, China Department of Biology, College of Life and Environment Science, Shanghai Normal University, Shanghai 200234, People’s Republic of China 3 Guangxi Medical University, Department of Physiology, Nanning 530021, China. lijing@gxmu.edu.cn Grenoble Alpes University, CNRS, Institut NÉEL, F-38042 Grenoble, France The State Key Laboratory of Solid Lubrication Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences Lanzhou 730000 China Department of Gastroenterology Tongji Hospital Tongji University Shanghai China a Biomedicine Key Laboratory of Shaanxi Province, Northwest University , Xi'an , P.R. China The Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, California 92121, United States College of Chemical Engineering China University of Petroleum (East China) Qingdao 266580 P. R. China Department of Rheumatology Jiangsu University Affiliated Hospital Zhenjiang Jiangsu China Department of Ophthalmology, The Central Hospital of Wuhan, Tongji Medical College Huazhong University of Science and Technology Wuhan China; Key Laboratory for Molecular Diagnosis of Hubei Province, The Central Hospital of Wuhan, Tongji Medical College Huazhong University of Science and Technology Wuhan China Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College; National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Ministry of Science & Technology; State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital; Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education , Beijing, China Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Department of Pancreatic Cancer, Tianjin, China Center for Drug Delivery and Nanomedicine, Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, Nebraska 68198, United States Department of Hematology, Hebei Province Hospital of Chinese Medicine, Shijiazhuang, Hebei 050013, P.R. China Brookhaven National Laboratory, Upton, New York 11973, United States; Department of Materials Science and Engineering, Stony Brook University, Stony Brook, New York 11720, United States Beijing Orbiepharm Co. Ltd. Beijing China International Phosphorus Laboratory, College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou 450001, P. R. China, Institut des Sciences Chimiques de Rennes, CNRS - Université de Rennes 1, Campus de Beaulieu, 35042 Rennes, France, Laboratoire de Physique des Interfaces et Couches Minces, CNRS UMR 7647, Ecole Polytechnique, 91128 Palaiseau, France, Laboratoire de Chimie des Surfaces et Interfaces, CEA Saclay, IRAMIS, SPCSI, 91191 Gif-sur-Yvette, France, and Nanyang Technological... Institute of Crop Sciences, Chinese Academy of Agricultural Sciences, Beijing 100081, China. College of Environmental and Resource Sciences, ZheJiang University, HangZhou, China; HangZhou Wufumei Bio-tech Co. Ltd, YuHang, China Department of Geriatrics, the Second Affiliated Hospital of Harbin Medical University, Harbin, China. Department of Allergy and Clinical Immunology, National Clinical Research Center for Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China Department of Critical Care Medicine, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital Third Hospital of Shanxi Medical University Taiyuan China Laboratory of Protein and Peptide Pharmaceuticals; Institute of Biophysics; Chinese Academy of Sciences; Beijing China; Laboratory of Proteomics; Institute of Biophysics; Chinese Academy of Sciences; Beijing China National Laboratory of Applied Organic Chemistry and Institute of Organic Chemistry, Lanzhou University, Lanzhou 730000, People's Republic of China Institute of Functional Material Chemistry Department of Chemistry Northeast Normal University Changchun 130024 P. R. China State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun 130012, P. R. China Zhejiang Normal University, China State Key Laboratory of Physical Chemistry of Solid Surfaces and Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China Department of Cardiovascular Medicine Affiliated Nanjing Brain Hospital Nanjing Medical University Nanjing China National Local Joint Laboratory for Advanced Textile Processing and Clean Production, State Key Laboratory of New Textile Materials and Advanced Processing Technologies, Wuhan Textile University, Wuhan 430073, China Sichuan University No 4 West China Teaching Hospital: Sichuan University West China School of Public Health Xidian University Information Center, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, China.; Sino-Finland Joint AI Laboratory for Child Health of Zhejiang Province, Hangzhou, China.; National Clinical Research Center for Child Health, Hangzhou, China. CAS Center for Excellence in Nanoscience Beijing Key Laboratory of Micro‐Nano Energy and Sensor Beijing Institute of Nanoenergy and Nanosystems Chinese Academy of Sciences Beijing 100083 P. R. China School of Computing, Informatics, Decision Systems Engineering Arizona State University Phoenix AZ USA Research Center for Eco‐Environmental Sciences Chinese Academy of Sciences Beijing 100085 China; Graduate School of Chinese Academy of Sciences Beijing 100039 China Department of Mechanical Engineering, The University of Hong Kong, Hong Kong, China. Department of Hematology and Oncology, The Fourth Hospital of Jinan, Jinan, Shandong 250031, P.R. China MedImmune, Mountain View, CA, USA 1Zai Lab (US) LLC, Menlo Park, California. Berry Oncology Corporation Beijing China Department of Epidemiology, School of Public Health Harbin Medical University Harbin Heilongjiang Province P. R. China Department of Spine Surgery, The Second Xiangya Hospital Central South University Changsha Hunan China School of Chemistry and Chemical Engineering Sun Yat‐sen University Guangzhou China *Department of Allergy and Clinical Immunology, Guangzhou Institute of Respiratory Health, State Key Laboratory of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China;; §Guangdong Provincial Key Laboratory of Allergy and Clinical Immunology, Guangzhou Medical University, Guangzhou 510260, China CAS Key Laboratory of Urban Pollutant Conversion, Department of Applied Chemistry, University of Science and Technology of China, Hefei 230026, P. R. China Institute of Medicinal Chemistry, School of Pharmaceutical Science, Lanzhou University Institute of Dermatology, Chinese Academy of Medical Sciences /National Center for STD Control, Chinese Center for Disease Control and Prevention, Nanjing 210042, China. Department of Spinal Surgery, Central South University, Changsha, China. Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, Hunan, PR China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, PR China School of Foreign Languages, Zhongyuan University of Technology, Zhengzhou 450007, P.R. China 1 Department of Electrical Engineering and Computer Science, Case Western Reserve University, Cleveland, OH 44106, USA and 2 Molecular and Computational Biology, University of Southern California, Los Angeles, CA 90089, USA School of Mechanical Engineering, Northwestern Polytechnical University, Xi’an, Shaanxi, 710072, China State Key Laboratory of Crop Biology; Key Laboratory of Biology and Genetic Improvement of Horticultural Crops (Huanghuai Region), Ministry of Agriculture; College of Horticulture Science and Engineering, Shandong Agricultural University, Tai’an, Shandong 271018, People’s Republic of China. Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China School of Materials Science and Engineering, South China University of Technology , Guangzhou 510006, China; National Engineering Research Center for Tissue Restoration and Reconstruction and Innovation Center for Tissue Restoration and Reconstruction , Guangzhou 510006, China; Laboratory of Biomedical Engineering of Guangdong Province, South China University of Technology , Guangzhou 510006, China Department of Chemistry and Howard Hughes Medical Institute, The University of Chicago, Chicago, Illinois 60637 Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110016, China Chonqing Institute of Green and Intelligent Technology Chinese Academy of Sciences Chongqing 400714 China Screening and Protein Sciences, Merck & Co., Inc., Rahway, New Jersey 07065, United States School of Pharmaceutical Sciences; South-Central University for Nationalities; Wuhan 430074; China; The Modernization Engineering Technology Research Center of Ethnic Minority Medicine of Hubei Province Beijing University of Posts and Telecommunications Department of Surgery (J.Li, J.S., M.G.C., P.R., M.E.S., B.M.E.), University of Kentucky, Lexington, Kentucky 40536;; Lucille P. Markey Cancer Center (J.Li, J.S., P.R., M.E.S., J.Liu, X.L., G.E., H.L.W., T.G., B.M.E.), University of Kentucky, Lexington, Kentucky 40536; Department of Chemistry; University of Shanghai for Science and Technology; Shanghai 200093; P. R. China Department of Gastroenterology, Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning 110033, China College of Food Science; Northeast Agricultural University; Harbin 150036; China Department of Infectious Diseases and Immunology, University of Florida, Gainesville, FL 32611; Department of Plastic and Burn Surgery Tangdu Hospital Fourth Military Medical University Xi'an 710038 China School of Public Health, Fudan University, Key Laboratory of Public Health Safety, Ministry of Education, Shanghai, China Guangdong-Hong Kong-Macau Joint Laboratory for Photonic-Thermal-Electrical Energy Materials and Devices Institute of Applied Physics and Materials Engineering University of Macau Avenida da Universidade Taipa, Macao SAR 999078 China College of Life Sciences, Northeast Agricultural University, Harbin 150030, China Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China Department of Chronic Disease Preventive and Control, Liaoning Provincial Center for Disease Control and Prevention, Shenyang, Liaoning, China (mainland) Department of Rheumatology, Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, China Key Laboratory of Bio‐Resources and Eco‐Environment (Ministry of Education) College of Life Sciences Sichuan University Chengdu 610065 China Department of Chemistry and Innovation Center of Pesticide Research, China Agricultural University, Beijing 100193, China Department of Chemistry, Texas A&M University, College Station, TX, USA School of Life Sciences; Northwest University; Xi'an Shaanxi China Renal Division, Peking University Shenzhen Hospital Peking University Beijing China State Key Laboratory of Pharmaceutical Biotechnology Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology NJU Advanced Institute for Life Sciences (NAILS) Nanjing University School of Life Sciences Nanjing University China Neurological Surgery, Department of Endocrinology and Metabolism, Suqian First Hospital, Suqian, China College of Chemistry and Molecular Sciences, State Key Laboratory of Virology, and The Institute for Advanced Studies, Wuhan University, Wuhan 430072, P. R. China Office of China National Narcotics Control Commission‐China Pharmaceutical University Joint Laboratory on Key Technologies of Narcotics Control Nanjing China; Key Laboratory of Drug Monitoring and Control Drug Intelligence and Forensic Center, Ministry of Public Security Beijing China Department of Surgery, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA National Engineering Research Center for Biomaterials, College of Biomedical Engineering, Sichuan University, Chengdu 610064, China Center for Drug Discovery, Northeastern University, 116 Mugar Hall, 360 Huntington Avenue, Boston, Massachusetts 02115, Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts, 02115, and Applied Biosystems, 500 Old Connecticut Path, Framingham, Massachusetts 01701 The Second Affiliated Hospital of Hunan University of Chinese Medicine Changsha Hunan China State Key Laboratory and Institute of Elemento-Organic Chemistry College of Chemistry Nankai University Weijin Road 94, Nankai District Tianjin 300071 P. R. China; Collaborative Innovation Center of Chemical Science and Engineering (Tianjin) Weijin Road 94#, Nankai District Tianjin 300071 P. R. China Department of Electrical Engineering and Computer Science, Case Western Reserve University, Cleveland, Ohio. Department of Ophthalmology Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai China Department of Instrument Science and Technology, Yanshan University , Qinhuangdao 066004, China Institute of Functional Nano and Soft Materials (FUNSOM); Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices; Joint International Research Laboratory of Carbon-Based Materials and Devices; Soochow University; Suzhou Department of Biological and Environmental Engineering, Hefei University, Hefei 230009, Anhui PR China |
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Total number of triples: 10000.