http://rdf.ncbi.nlm.nih.gov/pubchem/author/MD5_7ffcb51b26114c1e701e26bce7a919fd
Outgoing Links
Predicate | Object |
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family-name | Yong Liu Liu |
name | Yong Liu |
given-name | Yong |
organization-name | Institute of Orthopaedics, the 89th Hospital of Chinese PLA. a Institut für Pharmazeutische Biologie, Universität München , Karlstr. 29, D-80333, München, Germany From the Departments of Internal Medicine (J.C., Y.L., H.L., P.L.H., J.L.M.) and Physiology and Biophysics (J.C.), University of Arkansas for Medical Sciences and Central Arkansas Veterans Healthcare System, Little Rock, Ark. Longping Branch Graduate School of Hunan University Changsha China; Hunan Plant Protection Institute Hunan Academy of Agricultural Sciences Changsha China Institute of Neurobiology Xi'an Jiaotong University Health Science Center Xi'an Shaanxi Province China Key Laboratory for Silviculture and Conservation, Ministry of Education, Beijing Forestry University, Beijing, China; Key Laboratory for Silviculture and Forest Ecosystem in Arid and Semi-arid Area of State Forestry Administration, Beijing, China Anhui Key Laboratory of Chemo/Biosensing; College of Chemistry and Materials Science; Anhui Normal University; Wuhu; P. R. China 1Division of Cancer Immunotherapeutics and Tumor Immunology, Beckman Research Institute at City of Hope, Duarte, California and Department of Computer Science and Engineering, University of Oulu, Oulu, Finland. School of Pharmacy, Guangdong Medical University, Dongguan, Guangdong 523808, China National Center for AIDS/STD Control and Prevention of China CDC, Beijing, 102206, China Department of Radiology, Affiliated Tenth People's Hospital of Tongji University, Shanghai 200072, China. jkcchan@ha.org.hk Department of Physiology, Department of Chemistry State Key Laboratory of Marine Pollution City University of Hong Kong Hong Kong 999077 P. R. China Organ Transplantation Center, Shanghai First People’s Hospital, School of Medicine, Shanghai Jiao Tong University, 100 Haining Road, Shanghai 200080, China Institute of Neurobiology, Xi'an Jiaotong University College of Medicine, Xi'an, People's Republic of China. Cardiology Department of Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, China Department of General Surgery, Yan'an People's Hospital, Yan'an, China. Department of Medical Oncology, No.1 Central Hospital of Baoding City, Baoding Hebei 071000, PR China. Institute of Applied Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, Anhui, PR China Department of Cardiology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing Department of Cardiovascular Medicine, Wakayama Medical University Department of Critical Care Medicine Shenzhen Hospital, Southern Medical University Shenzhen Guangdong China Department of Hematology, Laboratory for Stem Cell and Regenerative Medicine, Affiliated Hospital of Weifang Medical University, Weifang, Shandong 261042, P.R. China Department of Urology/Shanghai Sperm Bank/Laboratory for Genetics and Sperm Development of Shanghai Institute of Andrology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200001, China. lambob1975@hotmail.com Department of Burn and Plastic Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China (mainland) Department of Chemical Etiology and Carcinogenesis, Cancer Institute (Hospital), Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100021, P.R.China. Department of Physiology, School of Medicine, University of Maryland, Baltimore, Maryland Department of Chemistry, Shanghai University, 99 Shangda Road, Shanghai 200444, People’s Republic of China Cardiovascular and Metabolic Diseases Key Laboratory of Luzhou, 646000 Luzhou, China. Key Laboratory of Medical Electrophysiology, Ministry of Education & Medical Electrophysiological Key Laboratory of Sichuan Province, (Collaborative Innovation Center for Prevention of Cardiovascular Diseases) Institute of Cardiovascular Research, Southwest Medical University, 646000 Luzhou, China. Department of Neurology, Lu'an People’s Hospital, Jin'an District, Lu'an, China CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety; CAS Key Laboratory of Standardization and Measurement for Nanotechnology; CAS Center for Excellence in Nanoscience; National Center for Nanoscience and Technology; Beijing 100190 School of Physics, Wuhan University, Wuhan 430072, PR China Beijing Engineering Research Center for BioNanotechnology; CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety; CAS Center for Excellence in Nanoscience; National Center for NanoScience and Technology; Beijing Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, Connecticut 06520-8103 Institute for Advanced Study, Shenzhen University, Shenzhen 518060, China; College of Mechatronics and Control Engineering, Shenzhen University, Shenzhen 518060, China E-mail: jxpathology@126.com. National Center for NanoScience & Technology Chinese Academy of Sciences Beijing 100190 China State Key Laboratory of Biocatalysis and Enzyme Engineering, School of Life Science, Hubei University, Wuhan 430062, China; Hubei Province Key Laboratory of Biotechnology of Chinese Traditional Medicine, National & Local Joint Engineering Research Center of High-Throughput Drug Screening Technology, Hubei University, Wuhan 430062, China Department of Otorhinolaryngology, Xiangya Hospital, Central South University, Changsha Hunan 410008, China. Department of Laboratory Medicine, Shengjing Hospital of China Medical University, Shenyang, China Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, China.; Hematologic Laboratory of Pediatrics, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, China. State Key Laboratory for Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China. National & Regional United Engineering Laboratory of Tissue Engineering, Department of Orthopaedics, Southwest Hospital, Third Military Medical University, P.R. China. Department of Chemistry and State Key Laboratory of Marine Pollution, City University of Hong Kong, Kowloon, Hong Kong, China School of Physics and Technology, Wuhan University, Wuhan 430072, People’s Republic of China Hematologic Laboratory of Pediatrics, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, People's Republic of China. Department of Neurosurgery, The Affiliated Brain Hospital, Nanjing Medical University, Nanjing; Key Laboratory of Drug Quality Control and Pharmacovigilance, Ministry of Education, ‡State Key Laboratory of Natural Medicine, and §Department of Organic Chemistry, China Pharmaceutical University, Nanjing 210009, China Heilongjiang Province Key Laboratory of Anti-fibrosis Biotherapy, Mudanjiang Medical University, Mudanjiang, 157011, Heilongjiang, China; Center for Comparative Medicine, Mudanjiang Medical University, Mudanjiang, 157011, Heilongjiang, China Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China; Anatomical and Cellular Pathology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China Celgene Corporation Summit NJ USA From the Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China (Z.Y., X.Y., J.W., Q.Q., A.P., H.L., Y.L., X.L.); Unilever Corporate Research, Sharnbrook, Bedfordshire, UK (O.H.F., K.L.R.); Health Sciences Research Institute, University of Warwick, Coventry, West Midlands, UK (O.H.F.); School of Health and Emergency Professions, University of Hertfordshire, Hatfield, Hertfordshire, UK ... Alkali Soil Natural Environmental Science Center, Northeast Forestry University, Harbin 150040, China; Key Laboratory of Saline-Alkali Vegetation Ecology Restoration in Oil Field, Ministry of Education, Harbin 150040, China; Heilongjiang Entry-Exit Inspection and Quarantine Bureau, Harbin 150001, China College of Chemistry and Chemical Engineering; Henan University; Kaifeng; P. R. China Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, The Institute for Advanced Studies, Wuhan University, Wuhan 430072, China National Health Commission Key Laboratory of Cardiovascular Regenerative Medicine Heart Center of Henan Provincial People's Hospital Central China Fuwai Hospital of Zhengzhou University Fuwai Central China Cardiovascular Hospital and Central China Branch of National Center for Cardiovascular Diseases Zhengzhou China; Department of Physiology Shanxi Medical University Taiyuan China Department of Nephrology the Key Laboratory for the Prevention and Treatment of Chronic Kidney Disease of Chongqing Kidney Center of PLA Xinqiao Hospital Army Medical University (Third Military Medical University) Chongqing 400037 China Department of Nephrology, The Key Laboratory for The Prevention and Treatment of Chronic Kidney Disease of Chongqing, Kidney Center of PLA, Xinqiao Hospital, Army Medical University (Third Military Medical University), Chongqing 400037, P.R. China Guangzhou Institute of Energy Conversion, Chinese Academy of Sciences, 510070, Guangzhou, China Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Institute for Advanced Studies,Wuhan University,Wuhan,China Intensive Care Unit, Suining Central Hospital, An Affiliated Hospital of Chongqing University, Suining, Sichuan, China. School of Artificial Intelligence , Beijing University of Posts and Telecommunications, Beijing 100876 , China School of Materials Science and Engineering, Harbin Institute of Technology, Harbin 150001, China State Key Laboratory of Metastable Materials Science and Technology & Key Laboratory for Microstructural Material Physics of Hebei Province, School of Science, Yanshan University, Qinhuangdao, 066004, P. R. China Faculty of Veterinary Medicine and Animal Science; Autonomous University of the State of Mexico; Toluca; Mexico; Key Laboratory of Subtropical Agro-ecological Engineering Department of Clinical Laboratory, Shengjing Hospital of China Medical University, Heping Ward, Shenyang, Liaoning 110003, China Department of Laboratory Medicine, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, Jiangsu, China Department of General Surgery, Third Xiangya Hospital, Central South University, No 138 Tongzipo Road, Changsha, Hunan, China College of Life Sciences and Food Engineering, Hebei University of Engineering, Handan, Hebei 056021, P.R. China Department of Forensic Medicine, Zun Yi Medical College, Zun Yi, People's Republic of China. Lab of Nanoscale Biosensing and Bioimaging Institute of Advanced Materials for Nano‐Bio Applications School of Ophthalmology & Optometry Wenzhou Medical University Wenzhou Zhejiang 325027 China Department of Pain and Rehabilitation, Xinqiao Hospital, Army Medical University, Chongqing, China College of Chemistry, Chemical Engineering and Materials Science Soochow University Suzhou 215123 China Department of Otolaryngology‐Head and Neck Surgery, Xiangya Hospital Central South University Changsha Hunan China; Otolaryngology Major Disease Research Key Laboratory of Hunan Province Changsha Hunan China; Clinical Research Center for Pharyngolaryngeal Diseases and Voice Disorders in Hunan Province Changsha Hunan China; National Clinical Research Center for Geriatric Disorders (Xiangya Hospital) Changsha Hunan China Laboratory of Pharmaceutical Resource Discovery, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian 116023, China Key Laboratory of Phytochemical R&D of Hunan Province, and Key Laboratory of Chemical Biology & Traditional Chinese Medicine Research (Ministry of Education), and Key Laboratory of the Assembly and Application of, Organic Functional Molecules of Hunan Province Hunan Normal University Changsha 410081 China Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin Key Laboratory of Pest Management of Horticultural Crop of Hunan Province Hunan Plant Protection Institute, Hunan Academy of Agricultural Science Changsha Hunan People's Republic of China Department of Chemical Engineering University of New Hampshire Durham, New Hampshire United States 03824 Department of Radiation Oncology, Shanghai General Hospital , 100 Haining Road, Hongkou District, Shanghai 200080 , China Department of Paediatric Surgery, Tianjin Medical University General Hospital, Tianjin, China Department of Gastric Cancer Surgery, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, China.; Tianjin Key Laboratory of Cancer Prevention and Therapy, National Clinical Research Center for Cancer, Tianjin, China. Key Laboratory of Cognition and Personality of Ministry of Education, Faculty of Psychology, Southwest University , Chongqing, 400715, China Department of Gynecology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China; Institute of Digestive Surgery and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China;; Department of Gastroenterological Surgery, West China Hospital, Sichuan University, Chengdu, China; School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P. R. China State Key Laboratory of Analytical Chemistry for Life Science School of Chemistry and Chemical Engineering Nanjing University Nanjing 210023 P. R. China Department of Veterinary and Animal Sciences, University of Copenhagen, Frederiksberg, Denmark. Department of Radiation Oncology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China Institute of High Performance Computing, Agency for Science, Technology, and Research (A*STAR), Singapore, Singapore School of Ophthalmology and Optometry; Wenzhou Medical University; Wenzhou; China Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100094, China. 4BeiGene, Zhong-Guan-Cun Life Science Park, Changping District, Beijing, China. Institute of Oncology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong Province, China Laboratory of Chemical Biology, Center for Molecular Science, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080, China, and Dyson Perrins Laboratory, Department of Chemistry, Oxford University, South Parks Road, Oxford, United Kingdom Department of Otolaryngology Head and Neck Surgery, Xiangya Hospital Central South University Changsha Hunan China; Otolaryngology Major Disease Research Key Laboratory of Hunan Province Changsha Hunan China; Clinical Research Center for Pharyngolaryngeal Diseases and Voice Disorders in Hunan Province Changsha Hunan China; National Clinical Research Center for Geriatric Disorders (Xiangya Hospital) Changsha Hunan China Hunan Provincial Key Laboratory for Biology and Control of Plant Diseases and Insect Pests, Hunan Agricultural University, Furong District, Changsha City, Hunan Province, 410128, P.R. China; Institute of Plant Protection, Hunan Academy of Agricultural Sciences, Changsha City, Hunan Province, 410125, P.R. China Geraldine Brush Cancer Research Institute, 2330 Clay Street, San Francisco, California 94115, USA. Department of Orthopedics, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Shuaifuyuan 1#, Beijing 100730, P. R. China. School of Materials Science and Engineering Qingdao University of Science and Technology Qingdao Shandong 266042 P. R. China Center of Systems Molecular Medicine, Department of Physiology, Medical College of Wisconsin, Milwaukee (P.L., Y. Liu, X.P., Y. Li, K.U., M.K.M., M.L.) State Key Laboratory of Silicon Materials; Department of Materials Science; Engineering; Zhejiang University; Hangzhou Center for Green Innovation School of Materials Science and Engineering University of Science and Technology Beijing Beijing 100083 China Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai; and Yunnan Academy of Tobacco Agricultural Sciences, Key Laboratory of Tobacco Biotechnological Breeding, National Tobacco Genetic Engineering Research Center, Kunming, 650021, PR China Shanghai Institute of Space Power-Sources School of Material Science and Engineering, Harbin Institute of Technology, Harbin 150001, China Department of Pathology, Jiangxi Provincial People's Hospital Affiliated to Nanchang University, Nanchang, Jiangxi 330006, P.R. China Department of Cardiology, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China; Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Guangzhou, China Department of Pain and Rehabilitation, The Second Affiliated (Xinqiao) Hospital, The Army (Third Military) Medical University, Chongqing Department of Microbiology, Bengbu Medical College, Anhui, PR China; Anhui Key Laboratory of Infection and Immunity, Bengbu Medical College, Anhui, PR China Cancer Research Institute, Fudan University Shanghai Cancer Center, Fudan University, Shanghai 200032, P. R. China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, P. R. China Key Laboratory of South China Sea Fishery Resources Exploitation & Utilization, Ministry of Agriculture and Rural Affairs, Guangdong Provincial Key Laboratory of Fishery Ecology and Environment, South China Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Guangzhou, China; Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), Guangzhou, China; Observation and Research Station of Pearl River Estuary Ecosystem, Guangzhou, China Laboratory of Pharmaceutical Resource Discovery, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China Department of Breast Surgery, The Third Affiliated Hospital of Guangzhou Medical University Guangzhou 510150, P. R. China. Department of Neurology, The First Affiliated Hospital of Chengdu Medical College, Chengdu, China. Max-Planck Institut für Kohlenforschung, Kaiser-Wilhelm-Platz 1, D-45470 Mülheim an der Ruhr, Germany Yucheng Maternal and Child Health Hospital, Dezhou 251200, China School of Physics and Technology, Wuhan University, Wuhan 430072, China; The Key Laboratory of Artificial Micro/Nano Structures of Ministry of Education, Wuhan University, Wuhan 430072, China Yunnan Academy of Tobacco Agricultural Sciences Kunming China Department of Orthopedic Surgery, The Affiliated Hospital of Qingdao University 16 Jiangsu Street, Qingdao, Shandong, China. Center for System Biology, Data Sciences, and Reproductive Health, School of Basic Medical Science, Central South University, Changsha 410011, China Department of Anatomy Engineering Research Center for Organ Intelligent Biological Manufacturing of Chongqing key Lab for Biomechanics and Tissue Engineering of Chongqing Third Military Medical University Chongqing 400038 P. R. China; Engineering Research Center of Tissue and Organ Regeneration and Manufacturing Ministry of Education Chongqing 400038 P. R. China; Zhongzhi Medical Valley Research Institute Chongqing 400030 P. R. China Zhejiang University Department of Preclinical Development, Merck & Co., Inc., West Point, PA, USA; Dongguan Scientific Research Center, Guangdong Medical University, Dongguan, Guangdong 523808, China; School of Pharmacy, Guangdong Medical University, Dongguan, Guangdong 523808, China; Key Laboratory for Research and Development of Natural Drugs of Guangdong Province, Zhanjiang, Guangdong 524023, China Department of General Surgery (Vascular Surgery), The Affiliated Hospital of Southwest Medical University , Luzhou 646000 , China; Cardiovascular and Metabolic Diseases Key Laboratory of Luzhou , Luzhou 646000, Sichuan , China; Key Laboratory of Medical Electrophysiology , Ministry of Education & Medical Electrophysiological Key Laboratory of Sichuan Province, Collaborative Innovation Center for Prevention and Treatment of Cardiovascular Disease of Sichuan Province, Institute of Cardiovascular Research, , Luzhou 646000, Sichuan , China; Southwest Medical University , Ministry of Education & Medical Electrophysiological Key Laboratory of Sichuan Province, Collaborative Innovation Center for Prevention and Treatment of Cardiovascular Disease of Sichuan Province, Institute of Cardiovascular Research, , Luzhou 646000, Sichuan , China Department of Gastric Cancer, Affilited Cancer Hospital, Tianjin Medical University, Tianjin 300060, China. libra_ly@163.com Department of Chemistry, University of Waterloo, 200 University Avenue West, Waterloo, Ontario, Canada, N2L 3G1 Department of Internal Medicine, University of Arkansas for Medical Sciences and Central Arkansas Veterans Healthcare System, Little Rock, AR 72205, U.S.A. Department of Otolaryngology-Head and Neck Surgery, The Xiangya Hospital, Central South University, Changsha, Hunan, China; Otolaryngology Major Disease Research Key Laboratory of Hunan Province, Changsha, Hunan, China; Clinical Research Center for Pharyngolaryngeal Diseases and Voice Disorders in Hunan Province, Changsha, Hunan, China; National Clinical Research Center for Geriatric Disorders, Changsha, Hunan, China Authors' Affiliations: 1Department of Cancer Immunotherapeutics and Tumor Immunology, Beckman Research Institute, City of Hope National Medical Center, Duarte, California; 2Department of Oncology, Johns Hopkins School of Medicine, Baltimore, Maryland; and 3Center for Translational Medicine, Shanghai Zhangjiang High-Tech Park, Shanghai, China Max-Planck-Institut für Festkörperforschung, Heisenbergstrasse 1, D-70569 Stuttgart, Germany. Merck & Co., Inc., Rahway, New Jersey 07065 United States Department of Neurology, Lu'an Affiliated Hospital of Anhui Medical University, Lu'an, China Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong General Hospital, Guangdong Academic of Medical Sciences, Guangzhou, China Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai, China School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, China Key Lab of Artificial Micro‐ and Nano‐Structures of Ministry of Education of China School of Physics and Technology Hubei Luojia Laboratory Wuhan University Wuhan Hubei 430072 China Shandong Museum, Jinan, PR China Hunan Academy of Agricultural Sciences, Institute of Plant Protection Changsha Hunan 410125 China Brainnetome Center & National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing, China; School of Artificial Intelligence, University of Chinese Academy of Sciences, Beijing, China; School of Artificial Intelligence, Beijing University of Posts and Telecommunications, Beijing, China. Electronic address: yongliu@bupt.edu.cn. School of Chinese Materia Medica Beijing University of Chinese Medicine Beijing China Research Institute of Powder Metallurgy, Central South University, Changsha 410083, People's Republic of China Institute of Fluorescent Probes for Biological Imaging School of Materials Science and Engineering School of Chemistry and Chemical Engineering University of Jinan Shandong 250022 P. R. China School of Materials Science and Engineering, Harbin Institute of Technology, Harbin 150001, China; National Key Laboratory for Precision Hot Processing of Metals, Harbin Institute of Technology, Harbin 150001, China Key Laboratory for Agro‐Ecological Processes in Subtropical Region National Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry Production, and Hunan Provincial Key Laboratory of Animal Nutritional Physiology and Metabolic Process Institute of Subtropical Agriculture The Chinese Academy of Sciences Changsha China Department of Liver Transplantation and Hepatobiliary Surgery, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong Province, China Department of Cardiothoracic Surgery, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325027, China State Key Laboratory of Catalysis, Dalian National Laboratory for Clean Energy, The Collaborative Innovation Centre of Chemistry for Energy Materials, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Zhongshan Road 457, Dalian 116023, China Department of General Surgery, Tianjin Xiqing Hospital, Tianjin 300380, P.R. China From the Department of Pharmacology & Cell Biophysics (C.K.L., W.Z., W.C, S.M.F., X.R., Y.L., W.K.J., E.G.K.) and Department of Internal Medicine (N.R., M.J., J.R.), University of Cincinnati College of Medicine, Cincinnati, OH; Molecular Biology Division, Center for Basic Research, Biomedical Research Foundation of the Academy of Athens, Greece (E.V., E.G.K.); Department of Physiology and Pathophysiology, Peking University Health Science Center, Beijing, China (Z.Z.); and the Department of... Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial Peoples Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510080 Guangdong, China School of Computer Science and Technology, Heilongjiang University, Harbin, China Department of Colorectal Surgery, The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences, Hangzhou, Zhejiang, China. From the Morehouse School of Medicine, Social Epidemiology Research Center (R.D.-D., Y.L., M.-V.B.) and Community Health and Preventive Medicine (F.S.), Atlanta, Ga. Department of Endoscopy, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing, P. R. China Engineering Research Center of the Ministry of Education for Intelligent Rehabilitation Equipment and Detection Technologies, Hebei University of Technology, Tianjin 300401, China; The Hebei Key Laboratory of Robot Sensing and Human-Robot Interaction, Hebei University of Technology, Tianjin 300401, China; School of Mechanical Engineering, Hebei University of Technology, Tianjin 300401, China School of Resources & Environment and Key Laboratory of Poyang Lake Environment and Resource Utilization Ministry of Education Nanchang University Nanchang 330031 China Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong 510080, P.R. China State Key Laboratory of Chemical Engineering, School of Chemical Engineering and Technology, Tianjin University, 135 Ya Guan Road, Jinnan District, Tianjin 300350, China Guizhou Juneng Chemical Co, Ltd, Huishui County of Guizhou Province, Huishui 550601, PR China Department of Orthopedic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College , Beijing , China Foshan (Southern China) Institute for New Materials, Foshan 528200, Guangdong, China Department of Neurosurgery, Center of Brain Science, The First Affiliated Hospital of Xi’an Jiaotong University Yunnan Academy of Tobacco Agricultural Sciences, Kunming, P.R. China School of Molecular Biosciences, Washington State University, Pullman, Washington 99164,1and Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China Department of Toxicology, Dalian Medical University, China, Laboratory of Pharmaceutical Resource Discovery, Dalian Institute of Chemical Physics, The Chinese Academy of Sciences, China, College of Laboratory Medicine, Dalian Medical University, China, Department of Biochemistry and Molecular Biology, Dalian Medical University, China, and Research and Development Office, Dalian Medical University, China School of Ophthalmology and Optometry School of Biomedical Engineering Wenzhou Medical University Wenzhou 325027 China National Joint Engineering Research Center for Abrasion Control and Molding of Metal Materials, Henan Key Laboratory of High-Temperature Structural and Functional Materials, Henan University of Science and Technology, Luoyang 471000, China Institute of Neurobiology, National Key Academic Subject of Physiology of Xi’an Jiaotong University School of Medicine, Xi’an, China Department of Physiology, Center of Systems Molecular Medicine (X.P., C.Y., P.L., M.L.R., Y. Li, A.M.B., Yong Liu, A.W.C., D.L.M., M.L.), Medical College of Wisconsin, Milwaukee. AIER Hefei Eye Hospital Affiliated to Anhui Medical University, Hefei, PR China School of Molecular Biosciences, Washington State University, Pullman, Washington 99164-4234,1 and Division of Materials Science & Engineering Ames Laboratory U.S. Department of Energy 2416 Pammel Drive Ames IA 50011-2416 USA School of Agricultural Engineering, Jiangsu University, Zhenjiang, PR China; Key Laboratory of Modern Agricultural Equipment and Technology, Ministry of Education, Jiangsu University, Zhenjiang, PR China Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, and Graduate School of the Chinese Academy of Sciences, Shanghai, China Department of Nephrology The Key Laboratory for the Prevention and Treatment of Chronic Kidney Disease of Chongqing Kidney Center of PLA Xinqiao Hospital Army Medical University (Third Military Medical University) Chongqing China Lab of Biosystem and Microanalysis State Key Laboratory of Bioreactor Engineering East China University of Science & Technology Shanghai 200237 China Drug Discovery Research Center, Southwest Medical University, Luzhou, Sichuan, China Department of Nephrology, The Key Laboratory for The Prevention and Treatment of Chronic Kidney Disease of Chongqing, Xinqiao Hospital, Third Military Medical University, Chongqing, 400037, China State Key Laboratory of Powder Metallurgy Central South University Changsha 410083 China College of Bioengineering, Chongqing University, Chongqing, China; Institute of Toxicology, College of Preventive Medicine, Third Military Medical University, Chongqing, China The Second School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong, China; Department of Cardiology, Provincial Key Laboratory of Coronary Heart Disease, Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital, Affiliated with South China University of Technology, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, China Center for Drug Discovery, Georgetown University Medical Center, Research Building, EP07, 3970 Reservoir Road, NW, Washington, D.C. 20057, United States College of Chemistry; Chemical Engineering and Materials Science; Soochow University; Suzhou; China Department of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha, P.R. China.; China National Clinical Research Center on Mental Disorders (Xiangya) & China National Technology Institute on Mental Disorders, Changsha, P.R. China.; Mental Health Institute of Central South University and Hunan Key Laboratory of Psychiatry and Mental Health, Changsha, P.R. China. Protein Analytical Chemistry, Genentech, Inc., South San Francisco, California 94080 Institute of Genetics and Development Biology, Chinese Academy of Science, Beijing 100101, China. yliu@genetics.ac.cn Department of Chemical Engineering, University of New Hampshire , 33 Academic Way, Durham, New Hampshire 03824, USA Institute of Advanced Materials for Nano-Bio Applications, School of Ophthalmology & Optometry, Wenzhou Medical College, Wenzhou, Zhejiang 325027, China Chengdu University of TCM, Chengdu 611137, China. lys372@163.com Cancer Institute Xuzhou Medical University Xuzhou China College of Veterinary Medicine, Northwest A&F University, Yangling, China School of Molecular Biosciences, College of Pharmacy, Washington State University, Pullman, WA Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China Central South University, Changsha 410011, China. Department of Laboratory Medicine, Shengjing Hospital of China Medical University, Shenyang 110004, China State Key Laboratory of Silicon Materials & School of Materials Science and Engineering; Zhejiang University; Hangzhou 310027; China Department of Cardiology The Fourth Central Hospital of Tianjin Tianjin China Henan Key Laboratory of Polyoxometalate Chemistry, College of Chemistry and Chemical Engineering, Henan University, Kaifeng 475004, P. R. China Authors' Affiliation: Department of Renal Transplantation and Urology, Shanghai First People's Hospital, Shanghai Jiaotong University, Shanghai, China College of Chemistry and Chemical Engineering, Henan University, Kaifeng 475004, P.R. China Colorectal Cancer Center, Department of General Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China Hunan Institute of Plant Protection, Changsha 410125, PR China Schlumberger-Doll Research, 1 Hampshire Street, Cambridge, Massachusetts 02139, and Department of Chemical Engineering, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio 44106 Department of Laboratory Medicine Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School Nanjing Jiangsu China Department of Pharmacy Hebei General Hospital Shijiazhuang P. R. China Chongqing Nanfang Numerical Control Equipment Co. Ltd , Chongqing , China College of Plant Protection Shandong Agricultural University Taian Shandong Province China Department of Chemical Engineering; University of New Hampshire; Durham; USA Department of Orthopedic Surgery Peking Union Medical College Hospital Peking Union Medical College and Chinese Academy of Medical Sciences Beijing China Xinjiang Key Laboratory of Explosives Safety Science, Xinjiang Technical Institute of Physics and Chemistry; Key Laboratory of Functional Materials and Devices for Special Environments, Chinese Academy of Sciences, Urumqi 830011, China; Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, Beijing 100049, China Department of Endoscopy, Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China Department of Urology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China (mainland) Cancer Research Institute, University of California, San Francisco, CA 94143-0128. Institute of Applied Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, P.R. China; Chinese Academy of Sciences Institute of Plasma Physics, , Hefei 230031, China School of Artificial Intelligence, Beijing University of Posts and Telecommunications, Beijing, China; Brainnetome Center & National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing, China; University of Chinese Academy of Sciences, Chinese Academy of Sciences, Beijing, China Foshan (Southern China) Institute for New Materials; Foshan; P. R. China Division of Population Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia Department of Chemistry; HKUST Jockey Club Institute for Advanced Study; Institute of Molecular Functional Materials; Division of Biomedical Engineering; State Key Laboratory of Molecular Neuroscience Department of Cardiovascular Surgery, Yan’an Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China (mainland) Institute of Functional Nano & Soft Materials (FUNSOM) Soochow University Suzhou Jiangsu China Department of Physiology, Center of Systems Molecular Medicine, Medical College of Wisconsin, Milwaukee, USA b Institute of Loess Plateau , Shanxi University , Taiyuan , P. R. China Analytical Research and Development, Merck Research Laboratories, Merck & Co., Inc., Rahway, New Jersey 07065, United States National Key Laboratory for Precision Hot Processing of Metals; School of Materials Science and Engineering, Harbin Institute of Technology, Harbin 150001, China Jun’an Disinfection Research Center 20 East Str., Fengtai District 100071 Beijing People's Republic of China Department of Interventional Therapy Beijing Shijitan Hospital Affiliated to Capital Medical University Beijing People's Republic of China; Department of Oncology Baoding First Central Hospital Baoding People's Republic of China Institute of Neurobiology, National Key Academic Subject of Physiology, Xi’an Jiaotong University, Xi’an 710016, P. R. China Analytical Science; MRL; Merck & Co.; Inc.; West Point Institute of Plant Protection, Sichuan Academy of Agricultural Sciences, Chengdu 610066, People's Republic of China Jiangsu Key Laboratory of Brain Disease Bioinformation, Research Center for Biochemistry and Molecular Biology, Xuzhou Medical College, Jiangsu 221004, China Department of Process and Analytical Chemistry, Merck Research Laboratories, Merck & Co., Inc., Rahway, New Jersey 07065, USA Department of Orthopedic, PUMC Hospital, CAMS and PUMC, Beijing 100730, China. Hunan Academy of Agricultural Sciences, Hunan Plant Protection Institute, Changsha, Hunan, China Southwest Hospital, Southwest Eye Hospital, Third Military Medical University, Chongqing, China.; Schepens Eye Research Institute, Harvard Medical School, Boston, Massachusetts. Department of Geriatrics, Xianyang Hospital, Yan'an University, Xianyang 712000, China. Department of Chemistry, University of Colorado at Denver, Denver, Colorado 80000, United States College of Material, Chemistry and Chemical Engineering, Key Laboratory of Organosilicon Chemistry and Material Technology of Ministry of Education, Hangzhou Normal University, Hangzhou, Zhejiang 311121, People’s Republic of China Collaborative Innovation Centre of Tissue Repair Material of Sichuan Province, China West Normal University, Nanchong 637009, China Campbell Family Institute for Breast Cancer Research, University Health Network, TMDT East Tower, MaRS Centre, 101 College Street, Toronto, Ontario MG5 1L7, Canada Brainnetome Center, National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China University of the Chinese Academy of Sciences Wenzhou Institute Regenerative Medicine CHINA Sichuan University, Chengdu, Sichuan 610065, P. R. China China National Research Institute of Food and Fermentation Industries, Beijing, People's Republic of China; China Center of Industrial Culture Collection, Beijing, People's Republic of China AIE Institute, Guangzhou 510530, China Anhui Institute of Optics and Fine Mechanics, Hefei Institutes of Physical Science, Chinese Academy of Sciences Anhui Provincial Engineering Technology Research Center for Biomedical Optical Instrument, Anhui Provincial Engineering Laboratory for Medical Optical Diagnosis Treatment Technology and Instrument Hefei China Department of Otolaryngology Head and Neck Surgery Xiangya Hospital, Central South University Changsha Hunan China; Otolaryngology Major Disease Research Key Laboratory of Hunan Province Changsha Hunan China Joint NTU-UBC Research Centre of Excellence in Active Living for the Elderly (LILY), Nanyang Technological University , Singapore, 639798, Singapore Key Laboratory of Water and Substrate Sciences (Ministry of Education) College of Environmental Sciences and Engineering Peking University Beijing China Research School of Polymeric Materials; School of Materials Science and Engineering; Jiangsu University; Zhenjiang 212013; China Department of Orthopedics, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China. Department of Endoscopy, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, P. R. China Brainnetome Center, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China Faculty of Psychology, Southwest University , Chongqing , China; Key Laboratory of Cognition and Personality of Ministry of Education, Southwest University , Chongqing , China College of Plant Protection, Hunan Agricultural University, Changsha 410128, China; Hunan Plant Protection Institute, Hunan Academy of Agricultural Sciences, Changsha 410125, China Systems Biology & Medical Center for Complex Disease Affiliated Hospital of Qingdao University Qingdao China; School of Medicine and Pharmacy Ocean University of China Qingdao China College of Animal Science and Veterinary Medicine, Shandong Agricultural University, Tai-an City 271018, People's Republic of China. National University of Singapore, DukeNUS Medical School, Singapore Anhui Province Key Laboratory of Embryo Development and Reproductive Regulation, Anhui Province Key Laboratory of Environmental Hormone and Reproduction, Institute of Life and Food Engineering, Fuyang Normal University, Fuyang, Anhui, China Institute of Toxicology College of Preventive Medicine, Third Military Medical University Chongqing China; Key Laboratory of Medical Protection for Electromagnetic Radiation Ministry of Education of China Chongqing China Jiangsu Key Laboratory for the Chemistry of Low-Dimensional Materials, School of Chemistry and Chemical Engineering, Huaiyin Normal University, Huai’an 223300, China Key Laboratory for Agro-Ecological Processes in Subtropical Region and South-Central Experimental Station of Animal Nutrition and Feed Science in Ministry of Agriculture, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha, Hunan 410125, People’s Republic of China; Facultad de Medicina Veterinaria y Zootecnia, Universidad Autónoma del Estado de México, Toluca, Estado de México C.P. 50090, Mexico Department of Respiratory Medicine, Capital Medical University, Beijing, China. Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100094, People's Republic of China, and Beijing Institute of Microchemistry Research, Beijing 100060, People's Republic of China College of Life Sciences and Bioengineering, Beijing Jiaotong University, Beijing, China; Tulane Center for Biomedical Informatics and Genomics, Deming Department of Medicine, School of Medicine, Tulane University, New Orleans, Louisiana State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Functional Polymer Materials, Ministry of Education, Institute of Polymer Chemistry, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Nankai University, Tianjin 300071, China Department of Endoscopy, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, P.R. China Department of Orthopedics Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan 430072, China. liuyong31279@whu.edu.cn. Department of Neurology, Xinqiao Hospital & The Second Affiliated Hospital, The Army Medical University (Third Military Medical University), Chongqing, China Department of Neurology, Lu’an Affiliated Hospital of Anhui Medical University, China (Y.L.) Ministry of Education Key Laboratory of Bioinorganic and Synthetic Chemistry, State Key Laboratory of Optoelectronic Materials and Technologies, School of Chemistry, School of Materials Science and Engineering, Sun Yat-Sen University, Guangzhou 510275, P. R. China Key Laboratory of Pest Management of Horticultural Crop of Hunan Province, Hunan Plant Protection Institute, Changsha, China; Branch of Longping, Graduate College, Central South University, Changsha, China Key Laboratory of Synthetic and Biological Colloids; Ministry of Education; School of Chemical and Material Engineering; Jiangnan University; Wuxi 214122 State Key Laboratory of Fine Chemicals Dalian University of Technology Dalian 116023 China College of Material, Chemistry and Chemical Engineering, Key Laboratory of Organosilicon Chemistry and Material Technology of Ministry of Education, Hangzhou Normal University, Hangzhou 311121, Zhejiang, People’s Republic of China Institute of Viruses and Infectious Diseases, Nanjing University, Nanjing, Jiangsu, China; Department of Laboratory Medicine, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, Jiangsu, China Department of Otolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha 410008, China; Otolaryngology Major Disease Research Key Laboratory of Hunan Province, Xiangya Hospital, Central South University, Changsha 410008, China; Clinical Research Center for Laryngopharyngeal and Voice Disorders in Hunan Province, Xiangya Hospital, Central South University, Changsha 410008, China Department of Entomology, College of Plant Protection Shandong Agricultural University Taian China School of Software Technology, Dalian University of Technology, Dalian 116620, China School of Safety Science and Engineering, Henan Polytechnic University, Jiaozuo, Henan 454003, China; State Key Laboratory Cultivation Base for Gas Geology and Gas Control, Henan Polytechnic University, Jiaozuo, Henan 454003, China State Key Laboratory of Electronic Thin Films and Integrated Devices, School of Optoelectronic Information, University of Electronic Science and Technology of China, Chengdu 610054, China Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Department of Orthopaedics, Beijing, China Institute of High Performance Computing, Agency for Science, Technology and Research (ASTAR), Singapore, Singapore Cancer Research Institute, Fudan University Shanghai Cancer Hospital, Fudan University, Shanghai 200032, PR China College of Environmental Sciences, Peking University, Beijing 100871, China. Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, School of Life Sciences, Jilin University, Changchun 130012, China Jiangsu University Department of Neurosurgery, Affiliated Nanjing Brain Hospital, Nanjing Medical University, Nanjing, People’s Republic of China School of Chinese Materia Medica, Beijing University of Chinese Medicine, No. 6 Wang Jing Zhong Huan Nan Lu, Chaoyang District, Beijing 100102, China School of Optoelectronic Information, MOEMIL Laboratory, University of Electronic Science and Technology of China, Chengdu 610054, China Department of Cardiothoracic Surgery, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325027, China Academician Workstation, Jiangxi University of Traditional Chinese Medicine, Nanchang, Jiangxi, P.R. China Department of Orthopaedics, Affiliated Hospital of Hebei University, Baoding City, Hebei Province, PR China School of Chemical Engineering and Technology, Collaborative Innovation, Center of Chemical Science and Chemical Engineering (Tianjin) Tianjin University Tianjin 300072 China Genetic Diagnosis Centre The First Hospital of Jilin University Changchun China College of Tobacco Science, Henan Agricultural University, Zhengzhou 450002, Henan, China. Second Department of Hepatobiliary, Institute for Regeneration Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China. liuyongjoy@hotmail.com CRRC Qingdao Sifang Locomotive and Rolling Stock Co., Ltd., Qingdao 266000, China From the Division of Vascular Surgery (M.W., G.-Q.C., C.-S.Y., X.-X.L., Y.L., T.-Y.C., X.-L.H., S.-M.W.), Laboratory of General Surgery (W.L.), and Division of Cardiac Surgery (J.-S.O.), First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China. Collaborative Innovation Center of Nonferrous Metals of Henan Province Henan Key Laboratory of High‐Temperature Structural and Functional Materials School of Materials Science and Engineering Henan University of Science and Technology Luoyang P. R. China Department of Cardiology Liaocheng People's Hospital Liaocheng Shangdong PR China Laboratory of Pharmaceutical Resource Discovery, Dalian Institute of Chemical Physics, Chinese Academy of Sciences; Graduate School of Chinese Academy of Sciences Institute of Neurobiology, Environment and Genes Related to Diseases Key Laboratory of Chinese Ministry of Education Xi'an Jiaotong University Xi'an China Center of Systems Molecular Medicine, Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA Department of Urology Huangshi Central Hospital Affiliated Hospital of Hubei Polytechnic University Edong Healthcare Group Huangshi China Department of Orthopaedic Surgery, the First Affiliated Hospital of Soochow University, Suzhou 215006, China. Center of Systems Molecular Medicine, Department of Physiology, Medical College of Wisconsin , Milwaukee, WI, 53226, USA Department of Ophthalmology, Chinese PLA General Hospital, Beijing, P.R. China. Key Laboratory of Artificial Micro-and Nano-structures of Ministry of Education and School of Physics and Technology, Wuhan University, Wuhan 430072, PR China Department of Pharmacology BeiGene (Beijing) Co., Ltd. China Department of General Surgery, Xinqiao Hospital, Third Military Medical University, Chongqing, China. School of Optoelectronic Science and Engineering University of Electronic Science and Technology of China Chengdu China The Traumatic Centre 89th Hospital of PLA, Weifang 261021, China. Department of Radiation Oncology Fudan University Shanghai Cancer Center Shanghai China Department of Biomedicine, Aarhus University, Aarhus, Denmark AVIC Beijing Institute of Aeronautical Materials; Beijing 100095; China; State Key Laboratory of New Ceramics and Fine Processing; Department of Materials Science and Engineering Division of Population Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, 4770 Buford Highway NE, Mailstop K-67, Atlanta, GA 30041, USA Department of Orthopedic Surgery, the First Affiliated Hospital of Soochow University, Suzhou Jiangsu, 215006, P.R. China. State Key Laboratory of Separation Membranes and Membrane Processes/National Center for International Joint Research on Separation Membranes, Tiangong University, Tianjin, PR People’s Republic of China; School of Textile Science and Engineering, Tiangong University, Tianjin, PR People’s Republic of China Chinese Academy of Sciences, Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Lanzhou 730000, People’s Republic of China and Graduate University of Chinese Academy of Sciences, Beijing 100039, People’s Republic of China School of Mechanical and Aerospace Engineering, Jilin University, Changchun 130025, China Department of Laboratory Medicine, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, Jiangsu, China. College of Material, Chemistry and Chemical Engineering, Key Laboratory of Organosilicon Chemistry and Material Technology of Ministry of Education, Hangzhou Normal University, Hangzhou 311121, Zhejiang, P.R. China State Key Laboratory of Powder Metallurgy; Central South University; Changsha 410083; PR China Jiangsu Rec-biotechnology Co. Ltd, Taizhou, 225300, China Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, China; These authors (Yuan-hui Liu, Yong Liu, Chong-yang Duan) contributed equally to this work Department of Orthopedic Surgery, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences Department of Neurosurgery, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, Jiangsu, China Department of Physiology, College of Integrated Chinese and Western Medicine, Anhui University of Chinese Medicine, Hefei, China College of Materials and Metallurgy, Guizhou University, Guiyang 550025, China Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Frontier Science Center for Immunology and Metabolism, and the Institute for Advanced Studies Wuhan University Wuhan Hubei China Department of Oncology, Ward II, Xuzhou Central Hospital, Xuzhou University of Hawaii - Manoa Department of Anatomy, National and Regional Engineering Laboratory of Tissue Engineering, State and Local Joint Engineering Laboratory for Vascular Implants, Key Lab for Biomechanics and Tissue Engineering of Chongqing, Third Military Medical University, Chongqing 400038, China Department of Orthopedics, Chengdu Second People's Hospital, Chengdu, Sichuan 610017, P.R. China Department of Otolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University , Xiangya Road, Kaifu District, Changsha, Hunan, 410008 , China Division of Hematology/Oncology, Department of Pediatrics, The Seventh Affiliated Hospital of Sun Yat-Sen University, Shenzhen 518107, China; Department of Pediatric Intensive Care Unit, The Seventh Affiliated Hospital of Sun Yat-Sen University, Shenzhen 518107, China Division of Population Health, Centers for Disease Control and Prevention, Atlanta, Georgia, USA State Key Laboratory of Organic‐Inorganic Composites College of Chemical Engineering Beijing University of Chemical Technology Beijing 100029 P. R. China School of Chinese Materia Medica, Beijing University of Chinese Medicine, 6A Wangjing Central South Road, Chaoyang District, Beijing 100102, China Departments of Ophthalmology, Chinese PLA General Hospital, Beijing, China. Department of Gynecology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China KingMed Diagnostics, Guangzhou 510330, China. Department of Orthopaedic Surgery, the Affiliated Hospital of Qingdao University, Qingdao, China Department of Otolaryngology Head and Neck Surgery Xiangya Hospital Central South University Changsha China; Otolaryngology Major Disease Research Key Laboratory of Hunan Province Changsha Hunan China Deparyment of Vascular Surgery, Affiliated Hospital of Luzhou Medical College Luzhou Sichuan, China. Hunan Plant Protection Institute, Hunan Academy of Agricultural Science, Changsha, China From the Pain Research Center and Guangdong Province Key Laboratory of Brain Function and Disease, Zhongshan Medical School, Sun Yat-Sen University, Guangzhou, Guangdong, People’s Republic of China (Z.-Z.H., D.L., X.-G.L., J.-Y.W., Y.L., W.-J.X.); Department of Anesthesiology, State Key Laboratory of Oncology in Southern China, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong, People’s Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China Key Laboratory of Catalysis and Materials Science of the State Ethnic Affairs Commission & Ministry of Education, Hubei Province, South-Central University for Nationalities, Wuhan 430074, P. R. China State Key Laboratory of Catalysis Dalian National Laboratory for Clean Energy Dalian Institute of Chemical Physics Chinese Academy of Sciences Dalian 116023 China Ultrasonography Laboratory of Pharmacology & Toxicology, School of Life Science and Medicine, Dalian University of Technology, Panjin 124221, People's Republic of China Center for Drug Discovery, Georgetown University Medical Center, 3970 Reservoir Road NW, Research Building, EP-07, Washington, D.C. 20057, United States; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, 3970 Reservoir Road NW, Research Building, Washington, D.C. 20057, United States CAF; National Engineering Laboratory for Biomass Chemical Utilization, Key and Open Laboratory on Forest Chemical Engineering, SFA, Key Laboratory of Biomass Energy and Material, Institute of Chemical Industry of Forest Products, Nanjing, Jiangsu 210042, China Intensive Care Unit, Southern Medical University Shenzhen Hospital, Shenzhen, China Department of Ophthalmology First Affiliated Hospital of Army Medical University of PLA Chongqing P. R. China Department of Colorectal Cancer, Zhejiang Cancer Hospital, Hangzhou, China. Department of Medical Oncology, Central Hospital of Xuzhou, Affiliated Xuzhou Hospital, Medical College of Southeast University, Xuzhou, China State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, Jilin, China Department of Experimental Medicine, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, 210008, Jiangsu Province, China Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai, China Southwestern Institute of Physics , Chengdu, Sichuan 610225, China Key Laboratory for Large-Format Battery Materials and System (Ministry of Education), School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Luoyu Road 1037, Wuhan 430074, P.R. China State Key Laboratory of Electronic Thin Films and Integrated Devices; University of Electronic Science and Technology of China; Chengdu 610054; China; School of Optoelectronic Science and Engineering 1Department of Laboratory Medicine, Shengjing Hospital of China Medical University, Shenyang, China; School of Food and Biological Engineering Hefei University of Technology Hefei China Department of Intensive Care Unit, Southern Medical University, Shenzhen, China Department of Neurology Xinqiao Hospital Third Military Medical University Chongqing China Southwest Hospital/Southwest Eye Hospital, Third Military Medical University (Army Medical University), Chongqing, China; and; Key Lab of Visual Damage and Regeneration & Restoration of Chongqing, Chongqing, China. College of Chemistry and Chemical Engineering; Henan University; Kaifeng; PR China Department of Cardiovascular Surgery, People's Hospital of Jian Yang, Jian Yan-China. State Key Laboratory for Powder Metallurgy; Central South University; Changsha 410083; P. R. China Institute of Plant Protection, Sichuan Academy of Agricultural Sciences, Chengdu 610066, P.R. China Brainnetome Center, Institute of Automation, Chinese Academy of Sciences, Beijing, China; National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing, China; Center for Excellence in Brain Science and Intelligence Technology, Institute of Automation, Chinese Academy of Sciences, Beijing, China; School of Artificial Intelligence, University of Chinese Academy of Sciences, Beijing, China Department of Physiology, Center of Systems Molecular Medicine, Medical College of Wisconsin, Milwaukee, WI, USA. yoliu@mcw.edu. Brainnetome Center National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences Beijing 100190 China Department of Gastrointestinal Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin, People’s Republic of China State Key Laboratory of Organic-Inorganic Composites College of Chemical Engineering Beijing University of Chemical Technology Beijing 100029 P. R. China Department of Cardiology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China; Department of Clinical Laboratory, Shengjing Hospital of China Medical University, Shenyang, China School of Physics and Technology, Center for Ion Beam Application, Center for Electron Microscopy and Hubei Nuclear Solid Physics Key Laboratory and ‡MOE Key Laboratory of Artificial Micro- and Nano-Structures, Wuhan University, Wuhan 430072, China Henan Key Laboratory of Polyoxometalate Chemistry, College of Chemistry and Chemical Engineering, Henan University, Kaifeng, Henan 475004, China Department of Electronic and Information Engineering Shanghai University of Electric Power Shanghai China The First Affiliated Hospital of Dalian Medical University Dalian 116011, China. Department of Neurosurgery and Clinical Research Center for Refractory Epilepsy of Shaanxi Province, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ShaanXi, China Department of Atmospheric, Oceanic, and Space Sciences, and Department of Chemistry, University of Michigan, Ann Arbor, Michigan 48109-2143 Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education; School of Life Sciences; Jilin University; Changchun 130012; China Department of Otorhinolaryngology Head and Neck Surgery, Central South University, Changsha, China. Key Laboratory of Artificial Micro‐ and Nano‐structures of Ministry of Education And School of Physical and Technology Wuhan University Wuhan 430072 P. R. China Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, P. R. China Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China. Department of Surgery Tianjin Xiqing Hospital Tianjin China Department of Experimental Medicine, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, Jiangsu, China. Department of Obstetrics, University of Arkansas for Medical Sciences, Little Rock, USA. Washington Department of Agriculture, Microbiology Laboratory, Olympia, Washington. Department of Gastrosurgery, Liaoning Cancer Hospital & Institute, Shenyang, PR China Shandong Hydrogen Energy Co., Ltd, Weifang, 261000, China School of Agricultural Engineering, Jiangsu University, Jiangsu, Zhenjiang, China School of Biological Sciences, Xuzhou Medical University, Xuzhou 221004, P.R. China; Jiangsu Key Laboratory of Brain Disease Bioinformation, Research Center for Biochemistry & Molecular Biology, Xuzhou Medical University, Xuzhou 221004, P.R. China From the Key Laboratory of Food Safety Research (B.X., Y.W., S.Z., Y.S., Yu Yu, D.C., G.C., D.K., J.T., Q.L., Ying Yu), Key Laboratory of Nutrition and Metabolism (Y.L.), Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China; Department of Cardiology, Shanghai Xuhui Central Hospital, Shanghai, China (S.-M.G., P.-Z.M.); Department of Biochemistry and Centre for Genomic Sciences, LKS Faculty of Medicine, The University of Hong... Department of Laboratory Medicine, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, Jiangsu, China; Department of Orthopedics, Union Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei 430022 China Department of Otorhinolaryngology, Xiangya Hospital, Central South University, Changsha 410008, China. Department of Process and Analytical Chemistry, Merck Research Laboratories, Merck and Co. Inc., Rahway, NJ 07065, USA. Heilongjiang University, Harbin 150000, China Translational Science Laboratory, Drum Tower Hospital, Affiliated Hospital of Medical College, Nanjing University, Nanjing, Jiangsu 210008, China. mliuyong@hotmail.com Clinical Laboratory, Shengjing Hospital of China Medical University, Shenyang, 110004, China Department of Cardiology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510630, Guangdong Province, P. R. China Department of Psychology, South China Normal University Institute of Liver Diseases, General Hospital of Beijing Military Region, Beijing 100700, China. Department Radiation Oncology, Shanghai General Hospital, Shanghai, China Institute of Applied Technology; Hefei Institutes of Physical Science; Chinese Academy of Sciences; Hefei; P. R. China Department of Respiratory Medicine,Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China. DNARx LLC, San Francisco, CA, USA. Biomedical Engineering Academy, School of Ophthalmology & Optometry, Wenzhou Medical College, 270 Xueyuan Road, Wenzhou 325027, China Department of Orthopaedics, Qilu Hospital, Shandong University, Jinan, Shandong 250012, China. Institute of Neurobiology, Xi'an Jiaotong University Health Science Center, Xi'an, China. Department of Ophthalmology, Air Force General Hospital, 30 Fucheng Road, Beijing 100142, China Aier School of Ophthalmology Central South University Changsha China; Wuhan Aier Eye Hospital Wuhan China Department of Neurology, Xinqiao Hospital, The Third Military Medical University, Chongqing 400037, China Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education) Department of Chemistry Tsinghua University Beijing 100084 P. R. China Institute of Neurobiology, School of Basic Medical Sciences, Xi’an Jiaotong University Health Science Center, Xi’an, China Institute of Loess Plateau, Shanxi University , Taiyuan, Shanxi, China Anhui Key Laboratory of Chemo/Biosensing, College of Chemistry and Materials Science, Anhui Normal University, Wuhu, Anhui 241000, P.R. China Department of Chemistry; Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials; State Key Laboratory of Molecular Engineering of Polymers; Laboratory of Advanced Materials; iChEM (Collaborative Innovation Center of Chemistry for Energy Materials); Fudan University; Shanghai 200433 China Department of Orthopedics, Orthopaedic Institute, The First Affiliated Hospital, Soochow University, Suzhou, China Department of Surgery School of Medicine, Hunan Normal University Changsha Hunan China Key Laboratory of Advanced Civil Engineering Materials; School of Materials Science and Engineering; Tongji University; Shanghai P. R. China School of Physics and Technology Hubei Luojia Laboratory Key Lab of Artificial Micro‐ and Nano‐Structures of Ministry of Education School of Microelectronics Wuhan University Wuhan 430072 China Department of Neurosurgery The Affiliated Brain Hospital with Nanjing Medical University Fourth Clinical College of Nanjing Medical University Nanjing China State Key Laboratory of Nuclear Physics and Technology, School of Physics, Peking University, Beijing100871, P. R. China; CAPT, HEDPS and IFSA, College of Engineering, Peking University, Beijing100871, P. R. China Department of Control Science , Institute of Cyber-Systems and Control, , Hangzhou, China; Zhejiang University , Institute of Cyber-Systems and Control, , Hangzhou, China Department of Emergency, First Affiliated Hospital of Nanchang University, Nanchang 330006, China Graduate Center for Toxicology, Departments of Physiology and Anatomy and Neurobiology, Chandler Medical Center, University of Kentucky, Lexington, Kentucky 40536-0305 From the Departments of Internal Medicine (K.C., J.C., J.L., J.X., D.L., T.S., P.L.H., J.L.M.) and Physiology and Biophysics (J.C., J.L.M.), University of Arkansas for Medical Sciences and Central Arkansas Veterans Healthcare System, Little Rock, Ark. Southwestern Institute of Physics 1 , Chengdu 610041, China Guangdong General Hospital, School of Medicine, South China University of Technology, Guangzhou, China; Department of Cardiology, Guangdong Cardiovascular Institute,Guangdong Provincial Key Laboratory of Coronary Disease, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China Department of Laboratory Medicine, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, Jiangsu, China From the Department of Physiology, Center of Systems Molecular Medicine, Medical College of Wisconsin, Milwaukee. Department of Otolaryngology Head and Neck Surgery, Xiangya Hospital Central South University Changsha China; Otolaryngology Major Disease Research Key Laboratory of Hunan Province Changsha China; Clinical Research Center for Pharyngolaryngeal Diseases and Voice Disorders in Hunan Province Changsha China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital Central South University Changsha China Lab of Nanoscale Biosensing and Bioimaging, Institute of Advanced Materials for Nano-Bio Applications, School of Ophthalmology & Optometry, Wenzhou Medical University, Wenzhou, Zhejiang 325027, China; Department of Chemistry and Biomolecular Science, Macquarie University, Sydney, New South Wales 2109, Australia Campbell Family Institute for Breast Cancer Research, TMDT East Tower, MaRS Centre, 101 College Street, Toronto, Ontario MG5 1L7, Canada Beijing Institute of Technology Laboratory of Nanoscale Biosensing and Bioimaging, Institute of Advanced Materials for Nano-Bio Applications, School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, Zhejiang 325027, China Department of Laboratory Medicine, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School Beijing Engineering Research Center for BioNanotechnology, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for NanoScience and Technology, No. 11 Zhongguancun Beiyitiao, Beijing 100190, P. R. China; University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing 100049, P. R. China School of Resource & Environment and Safety Engineering, University of South China, Hengyang, Hunan 421001, People's Republic of China; Hunan Province Engineering Technology Research Center of Uranium Tailings Treatment Technology, Hengyang, Hunan 421001, People's Republic of China; Hunan Province Engineering Research Center of Radioactive Control Technology in Uranium Mining and Metallurgy, Hengyang, Hunan 421001, People's Republic of China The authors are considered equally as corresponding authors; Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, China School of biological and food engineering, Fuyang Teachers College, Fuyang 236037, China;Key Laboratory of Embryo Development and Reproductive Regulation in Anhui, Fuyang 236037, China. Surgical Department of Colorectal Cancer, Zhejiang Cancer Hospital, Hangzhou, Zhejiang Province, China; Charité Comprehensive Cancer Center, Berlin, Germany Department of Neurosurgery The Affiliated Brain Hospital of Nanjing Medical University Nanjing China Institute of High Performance Computing, A*STAR, Singapore Department of Neurosurgery The Nanjing Brain Hospital Affiliated to Nanjing Medical University Nanjing Jiangsu Province China Department of Orthopedic Surgery Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College Beijing China School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China California Pacific Medical Center, Cancer Research Institute, San Francisco, CA 94115 Key Laboratory for Organic Electronics and Information Displays & Jiangsu Key Laboratory for Biosensors, Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing University of Posts & Telecommunications, Nanjing 210023, China Guangzhou Medical University Guangzhou China; Kingmed Virology Diagnostics and Translational Center Guangzhou Kingmed Center for Clinical Laboratory Guangzhou China; Guangzhou Institute of Respiratory Health The First Affiliated Hospital of Guangzhou Medical University Guangzhou China Scientific Research Division Sharing Platform for Scientific Research Mudanjiang Medical University, Mudanjiang 157011, China Department of Neurology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China; Department of Neurology, The First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan, 610500, China School of Computer Science and Technology, Heilongjiang University, Harbin 150080, China Department of Human Anatomy, Histology and Embryology, and Institute of Neurobiology Health Science Center, Xian Jiaotong University Xi'an Shanxi China Capital Medical University Affiliated Beijing Obstetrics and Gynecology Hospital, Beijing 100006, China. Qingdao University of Science and Technology, College of Information Science and Technology, Qingdao, China College of Environmental Science and Engineering, Key Laboratory of Water and Sediment Sciences (MOE), Peking University, Beijing 100871, China Department of Analytical Sciences, Merck Research Laboratories, Merck &Co., Inc., Rahway, New Jersey 07065, United States Department of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China, Mental Health Institute of Central South University & Hunan Key Laboratory of Psychiatry and Mental Health, Changsha, China, China National Clinical Research Center on Mental Disorders (Xiangya) & China National Technology Institute on Mental Disorders, China Department of Chemistry, University of Colorado Denver, Denver, Colorado 80217, United States School of Optoelectronic Information University of Electronic Science and Technology of China Chengdu 610054 China Department of Ultrasound Beijing‐Shijitan Hospital Beijing China State Key Laboratory of Medicinal Chemical Biology Materials and Ministry Key Laboratory of Functional Polymer Materials of Ministry of Education Institute of Polymer Chemistry College of Chemistry Nankai University 94 Weijin Road Tianjin 300071 P. R. China; Department of Biomedical Engineering University of Groningen and University Medical Center Groningen Antonius Deusinglaan 1, 9713 AV Groningen The Netherlands Foshan (Southern China) Institute for New Materials Foshan Guangdong 528200 China Department of Process and Analytical Chemistry and Department of Structural Chemistry, Merck Research Laboratories, Merck & Co., Inc., Rahway, New Jersey 07065, United States Surgical Department of Colorectal Cancer, Zhejiang Cancer Hospital, Hangzhou, Zhejiang Province, China; Charité Comprehensive Cancer Center, Labor AG Keilholz, Berlin, Germany Department of Chemistry and State Key Laboratory of Marine Pollution, City University of Hong Kong, Kowloon, Hong Kong 999077, China University of Electronic Science and Technology of China Department of Pediatrics, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, People’s Republic of China; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, People’s Republic of China Department of Immunology Guangzhou Kingmed Diagnostics Group Co., Ltd. Guangzhou Guangdong China Institute of Neurobiology Xi'an Jiaotong University Health Science Center Xi'an Shaanxi People's Republic of China From the Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China (Y.L., J.-Y.C., N.T., Y.-L.Z., D.-Q.Y., Z.-J.C., Y.-T.H., Y.-H.L., J.-F.L., W.-H.H., G.L., P.-C.H., J.-Q.Y., N.-J.X., X.-Q.L., D.-H.Y., S.-J.H., P.-Y., H.-L.L., P.R., C.-Y.D.); and Department of Biostatistics, School of Public Health and Tropical Medicine, Southern Medical University, Guangzhou, China (C.-Y.D., P.-Y.C.). State Key Laboratory of Powder Metallurgy Central South University 932 Yuelushan South Road Changsha 410083 P. R. China Department of Orthopedic Surgery, Peking Union Medical College Hospital , Dongcheng-qu , China Brainnetome Center, Institute of Automation, Chinese Academy of Sciences, Beijing, China; National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing, China Department of Microbiology, Bengbu Medical College, Bengbu, Anhui 233030, PR China; Anhui Key Laboratory of Infection and Immunity, Bengbu Medical College, Bengbu, Anhui 233030, PR China Department of Medicinal Chemistry, ‡Department of Process and Analytical Chemistry, and ¶Department of Chemistry Modeling and Informatics, Merck Research Laboratories, Merck & Co., Inc., PO Box 2000, Rahway, New Jersey 07065, United States; Department of Pharmacology and ⊥Department of Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck Research Laboratories, Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States; Department of Pharmacokinetics, Pharmacodynamics and Drug Metabolism, and §Department of Pharmacology, Merck Research Laboratories, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, New Jersey 07033, United States Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, the Institute for Advanced Studies,Wuhan University,Wuhan,China State Key Laboratory of Catalysis & Division of Solar Energy Dalian National Laboratory for Clean Energy Dalian Institute of Chemical Physics Chinese Academy of Sciences Dalian 116023 China Department of Neurology, Xinqiao Hospital, The Third Military Medical University, Chongqing, China Joint NTU-UBC Research Centre of Excellence in Active Living for the Elderly , Singapore, Singapore Department of Biomedical Engineering, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands National Engineering Research Center for Biomaterials and ‡College of Chemistry, Sichuan University, 29 Wangjiang Road, Chengdu 610064, China Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Key Laboratory of Coronary Disease, Guangdong General Hospital, Guangdong Academy of Medical Sciences; School of Medicine, South China University of Technology School of Resources & Environment and Key Laboratory of Poyang Lake Environment and Resource Utilization Ministry of Education Nanchang University Nanchang 330031 P. R. China Campbell Family Institute for Breast Cancer Research, University Health Network, TMDT East Tower, MaRS Centre, 101 College Street, Toronto, Ontario M5G 1L7, Canada Beijing Engineering Research Center for BioNanotechnology & CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety; CAS Center for Excellence in Nanoscience; National Center for Nanoscience and Technology; Beijing 100190; P. R. China Department of Cardiology Liaocheng People’s Hospital Liaocheng China School of Environmental Science and Engineering; Tianjin University; Tianjin 300354; China From the Singapore Eye Research Institute (C.V., R.P.N., Z.T., J.L.L., S.S., S.T., D.S.W.T., T.Y.W., D.M.); Duke–NUS Medical School (R.P.N., J.L.L., S.S., S.T., T.Y.W., D.M.); Institute of High Performance Computing (X.X., Y.L.), Agency for Science, Technology and Research (A*STAR); Singapore National Eye Centre (J.L.L., S.S., S.T., D.S.W.T., T.Y.W., D.M.); University of Berkeley (L.M.), CA; Departments of Ophthalmology and Neurology (N.J.N., V.B.), Emory University School of Medicine, Atlanta, GA;... Department of Otorhinolaryngology, Xiangya Hospital, Central South University, Changsha, 410008, China. Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of Coronary Disease, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China; Key Laboratory of Systems Biology, Institute for Nutritional Sciences (Q.Q., Z.Y., X.Y., F.Z., P.H., J.W., H.L., Y.L., X.L.), Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Graduate School of the Chinese Academy of Sciences, Shanghai 200031, China First Affiliated Hospital of Anhui University of Chinese Medicine Hefei People's Republic of China Department of Mechanical Engineering City University of Hong Kong Hong Kong China; Key Laboratory of Near Net Forming of Jiangxi Province Nanchang University Nanchang 330031 P. R. China State Key Laboratory of Catalysis Dalian National Laboratory for Clean Energy Dalian Institute of Chemical Physics Chinese Academy of Sciences Dalian 116023 P. R. China Department of Orthopaedic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Science, Beijing 100730, China. Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education); Department of Chemistry; Tsinghua University; Beijing 100084; P. R. China Brainnetome Center Institute of Automation Chinese Academy of Sciences Beijing China; National Laboratory of Pattern Recognition Institute of Automation Chinese Academy of Sciences Beijing China; CAS Center for Excellence in Brain Science and Intelligence Technology Institute of Automation Chinese Academy of Sciences Beijing China; University of Chinese Academy of Sciences Beijing China Key Laboratory of Photovoltaic and Energy Conservation Materials, CAS, Hefei, 230088, China Department of Process and Analytical Chemistry, Merck Research Laboratories, Merck and Co., Inc., 07065, Rahway, NJ, USA Hefei Institute of Physical Science; Chinese Academy of Sciences; Hefei 230036; PR China; University of Science and Technology of China Southwestern Institute of Physics , P.O. Box 432, Chengdu 610041, China School of Science Hainan University Haikou 570228 China Department of Orthopaedic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, 1 Shuaifu Yuan , Beijing 100730, China Department of Ophthalmology, General Hospital of Air Force Beijing 100142, China. Longping Branch Graduate School of Hunan University Changsha 410125 China; Hunan Plant Protection Institute Hunan Academy of Agricultural Science Changsha 410125 China Institute of Cyber-Systems and Control, Zhejiang University, Hangzhou 310027, China Department of Gastroenterology, The Fourth Affiliated Hospital of Harbin Medical University Harbin, China. Key Laboratory of Functional Polymer Materials of Ministry of Education, State Key Laboratory of Medicinal Chemical Biology and Institute of Polymer Chemistry, College of Chemistry, Nankai University, Tianjin, 300071, China; Department of Biomedical Engineering, University of Groningen and University Medical Center Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian National Laboratory for Clean Energy, Dalian 116023, China; Graduate University of Chinese Academy of Sciences, Beijing 100049, China School of Physics and Technology, Hubei Luojia Laboratory, Key Lab of Artificial Micro‐ and Nano‐Structures of Ministry of Education School of Microelectronics Wuhan University Wuhan 430072 China Department of Pathology, The Affiliated Hospital of Luzhou Medical College Zhongshan Road 319, Luzhou, 646000, China. College of Plant Protection; Shandong Agricultural University; Taian Shandong China State Key Lab of Pollution Control and Resource Reuse, Tongji University, Shanghai 200092, China Affiliated Hospital of Traditional Chinese Medicine, Southwest Medical University, Luzhou, China. Institute of Mental Health The Second Xiangya Hospital, Central South University Changsha China; The National Clinical Research Center for Mental Health Disorders Changsha China; The National Technology Institute of Psychiatry Changsha China; Key Laboratory of Psychiatry and Mental Health of Hunan Province Changsha China CAS Key Laboratory for Agro-Ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha, Hunan, China State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, P. R. China Southwest Hospital/Southwest Eye Hospital, Third Military Medical University (Army Medical University), Chongqing, China. Department of Orthopedic Surgery, Xiehe Hospital, Tongji Medical School, Huazhong University of Science and Technology, Wuhan, Hubei, P. R. China 430022. School of Physics and Technology, and the Key Laboratory of Artificial Micro/Nano Structures of Ministry of Education, Wuhan University, Wuhan 430072, China Department of Laboratory Medicine Shengjing Hospital of China Medical University Shenyang China School of Food and Biological Engineering Hefei University of Technology Hefei 230009 China School of Chemistry and Chemical Engineering Central South University Changsha Hunan 410083 China Medical Systems Biology Center for Complex Diseases Affiliated Hospital of Qingdao University Qingdao China Department of Medical Oncology, Xuzhou Hospital Affiliated to Medical College of Southeast University and Xuzhou Central Hospital, Xuzhou, China Department of Cardiology, Third Affiliated Hospital, Sun Yat-sun University, Guangzhou 510630, China. lyong1968@163.com Department of Geriatric Medicine, Shanghai Eighth People's Hospital, Shanghai, China; Institute of Materials, China Academy of Engineering Physics, Mianyang 621908, Sichuan, China Tulane Center of Biomedical Informatics and Genomics, Deming Department of Medicine, Tulane University School of Medicine, Tulane University, New Orleans, LA 70112, USA; School of Basic Medical Science, Central South University, Changsha 410013, Hunan Province, PR China California Pacific Medical Research Institute, San Francisco, CA 94115; Department of Pathology, University of Oklahoma School of Medicine, Oklahoma City, OK 73104; and Auerback Melanoma Research Laboratory, Cutaneous Oncology Program, University of California San Francisco Cancer Center and Department of Dermatology, University of California, San Francisco, CA 94115 Guangzhou Institute of Energy Conversion, 510070, Guangzhou, China ncliuyong@sohu.com Institute of Neurobiology, School of Basic Medical Sciences and Key Laboratory of Environment and Genes Related to Diseases (Xi’an Jiaotong University), Ministry of Education of China, Xi’an Jiaotong University Health Science Center Xi’an China Department of Cardiology, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou 510080, China; Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Guangzhou 510080, China Department of Colorectal Cancer, Zhejiang Cancer Hospital, Hangzhou 310022, China. liuyong666@hzcnc.com Celgene Corporation Summit New Jersey Ministry of Education Key Laboratory of Bioinorganic and Synthetic Chemistry; State Key Laboratory of Optoelectronic Materials and Technologies; School of Chemistry; School of Materials Science and Engineering; Sun Yat-Sen University Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Institute for Advanced Studies, Wuhan University, Wuhan 430072, China. Science and Technology Information Center, PetroChina West East Gas Pipeline Company, Wuhan 430074, Hubei, China Department of Hand Surgery the Fifth Hospital of Harbin Harbin China College of Food Science and Engineering, Tianjin University of Science and Technology, Tianjin, China Department of Joint Surgery First Affiliated Hospital of Sun Yat‐sen University Guangzhou China Brainnetome Center and National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing, China Department of Chemistry, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Laboratory of Advanced Materials, iChEM (Collaborative Innovation Center of Chemistry for Energy Materials), Fudan University, Shanghai, 200433, PR China Subcollege of Longping Graduate School of Hunan University Changsha China; Institute of Plant Protection Hunan Academy of Agricultural Sciences Changsha China Institute of Loess Plateau, Shanxi University, Taiyuan 030006, China The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University Luzhou Sichuan China From the Department of Physiology (Y.L., P.L., C.Y., A.W.C., M.L.) and Cancer Center (P.L.), Medical College of Wisconsin, Milwaukee. Department of Physiology, Center of Systems Molecular Medicine, Medical College of Wisconsin, Milwaukee. Institute of Applied Technology, Hefei Institutes of Physical Science; Chinese Academy of Sciences; Hefei China Department of Urology, West China Hospital, Sichuan University, Chengdu, China. 1 Authors' Affiliations:Cancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, P.R. China; Department of Endoscopy, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, P.R. China Southwest Hospital/Southwest Eye Hospital, Third Military Medical University (Army Medical University), Chongqing, China Key Laboratory for Microstructural Material Physics of Hebei Province, School of Science, Yanshan University , Qinhuangdao 066004, China Departments of Cancer Immunotherapeutics and Tumor Immunology, 1.Key Laboratory of Embryo Development and Reproductive Regulation of Anhui Province, Fuyang 236041, China. 2.College of Life Science, Fuyang Normal University, Fuyang 236041, China. Research Center of Deciduous Oaks, Beijing Forestry University, Beijing 100083, China; National Innovation Alliance of Valuable Deciduous Tree Industry, Beijing Forestry University, Beijing 100083, China; Key Laboratory for Silviculture and Conservation, Ministry of Education, Beijing Forestry University, Beijing 100083, China; Beijing Laboratory of Urban and Rural Ecological Environment, Beijing Forestry University, Beijing 100083, China Department of Orthopaedic Surgery Department of Dermatology Shaanxi Provincial Hospital of Chinese Medicine Xi'an 710003 China Department of Orthopaedic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China Department of Orthopedics, the First Hospital Affiliated to Soochow University, Suzhou Jiangsu, 215006, P.R.China. Key Laboratory for Micro-Nano Physics and Technology of Hunan Province; School of Physics and Electronics; Hunan University; Changsha 410082; People's Republic of China School of Civil and Surveying & Mapping Engineering, Jiangxi University of Science and Technology, Ganzhou, People’s Republic of China Key Laboratory of Artificial Micro- and Nano-structures of Ministry of Education; School of Physics and Technology; Wuhan University; Wuhan 430072; People's Republic of China Brainnetome Center, Institute of Automation, Chinese Academy of Sciences, Beijing, China.; National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing, China. Department of Pathology, Affiliated Hospital of Luzhou Medical College, Luzhou, China Hunan Key Laboratory of Ultra-Precision Machining Technology Department of Radiology, Affiliated Tenth People's Hospital of Tongji University, Shanghai, China Institute of Applied Technology Hefei Institutes of Physical Science, Chinese Academy of Sciences Hefei China Department of Ultrasound, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China. Corresponding author: Chen Wei, Email: hanwa63@126.com. Department of Neurobiology, Institute of Basic Medical Sciences, State Key Laboratory of Proteomics, Beijing, P. R. China. Department of Respiratory and Critical Care Medicine, Zhoukou Central Hospital, Zhoukou, Henan 466000, China School of Chemistry; School of Materials Science and Engineering; Sun Yat-sen University; Guangzhou; P. R. China Institute of Atomic and Molecular Physics, Jilin University, Changchun 130012, China Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin; and School of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, China State Key Laboratory of Proteomics and Department of Neurobiology, Department of Neurobiology, Institute of Basic Medical Sciences, Beijing, China. Pain Department, First Affiliated Hospital of Gannan Medical University, Ganzhou, China; Pain Medical Institute of Gannan Medical University, Ganzhou, China; Pain Medical Engineering Technology Center, Ganzhou, China Department of Laboratory Medicine Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School Nanjing China National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China; Brainnetome Center, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China Pfizer Global Research & Development Ann Arbor Michigan State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University , Guangzhou 510120 , China; Kingmed Virology Diagnostic & Translational Center, Guangzhou Kingmed Center for Clinical Laboratory Co., Ltd, Guangzhou 510330 , China Max-Planck-Institut für Kohlenforschung, Kaiser-Wilhelm-Platz 1, 45470 Mülheim an der Ruhr, Germany School of Chemistry & Chemical Engineering, State Key Laboratory of Metal Matrix Composites, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, P.R. China Clinical Pharmacology Department, Celgene, 86 Morris Avenue, Summit, NJ 07901, USA Merck Research Laboratories, PO Box 2000, RY818-C220, Rahway, NJ 07065, USA Institute of Neurobiology Xi'an Jiaotong University College of Medicine Xi'an Shaanxi 710061 PR China State Key Laboratory for Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China Department of Nephrology, Ganzhou Hospital of Guangdong Provincial People’s Hospital, Ganzhou Municipal Hospital, Ganzhou, China Key Laboratory for Micro‐Nano Physics and Technology of Hunan Province College of Materials Science and Engineering Hunan University Changsha 410082 P. R. China Department of Chemistry and State Key Laboratory of Marine Pollution City University of Hong Kong Hong Kong 999077 China State Key Laboratory of Hybrid Rice, Institute of Plant Protection, Hunan Academy of Agricultural Sciences, Changsha 410125, China School of Natural Resources & Environment, University of Michigan, Ann Arbor, Michigan 48109 Yunnan Academy of Tobacco Agricultural Sciences and China Tobacco Breeding Research (Southern) Center, Yuxi 653100, China College of Pharmaceutical Sciences and ‡Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, P.R. China National Engineering Research Centre for Biomaterials; Sichuan University; Chengdu 610064; China Division of Population Health, National Center for Chronic Disease Prevention and Health Promotion, CDC. School of Life and Pharmaceutical Sciences, Dalian University of Technology, Panjin, China Department of Burn and Plastic Surgery, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China School of Chemistry and Chemical Engineering, Tianjin University of Technology, Tianjin 300384, P. R. China 4Department of Clinical Laboratory, Shengjing Hospital of China Medical University, Shenyang, China. Auerback Melanoma Research Laboratory, Cutaneous Oncology Program, University of California at San Francisco Cancer Center and Department of Dermatology, University of California, San Francisco, CA 94115; California Pacific Medical Research Institute, San Francisco, CA 94115; Department of Pathology, Northwestern University School of Medicine, Evanston, IL 60201; and Department of Comparative Medicine, University of Washington, Seattle, WA 98195 Department of Obstetrics and Gynecology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA Department of Neurology, Taihe Hospital Hubei University of Medicine Shiyan China Department of Chemistry, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Key Laboratory of Molecular Engineering of Polymers, iChEM (Collaborative Innovation Center of Chemistry for Energy Materials), Laboratory of Advanced Materials, Fudan University, Shanghai 200433, China. Key Laboratory of Cognition and Personality (Ministry of Education), Southwest University, Chongqing, China; Department of Psychology, Southwest University, Chongqing, China The Key Laboratory of Synthetic and Biological Colloids; Ministry of Education; School of Chemical and Material Engineering; Jiangnan University; Wuxi 214122 Department of Orthopedic Surgery Peking Union Medical College Hospital, Chinese Academy of Medical Sciences Beijing China Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China School of Chemistry and Chemical Engineering, Tianjin University of Technology, Tianjin 300384, P.R. China Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Department of Pediatrics, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, Guangdong Province, People’s Republic of China School of Materials Science and Engineering; Harbin Institute of Technology; Harbin; China Department of Otolaryngology Head & Neck Surgery, Xiangya Hospital, Central South University, Xiangya Road 87, Changsha 410008, Hunan, China; Otolaryngology Major Disease Research Key Laboratory of Hunan Province, Changsha 410008, Hunan, China The Affiliated Hospital of Qingdao University, China Department of Radiation Oncology and Lineberger Comprehensive Cancer CenterSchool of MedicineUniversity of North Carolina at Chapel HillChapel HillNorth CarolinaUSA; Jiangsu Center for the Collaboration and Innovation of Cancer BiotherapyCancer InstituteXuzhou Medical CollegeXuzhouChina Longping Branch School of Biology, Hunan University Changsha China; Institute of Plant Protection Hunan Academy of Agricultural Sciences Changsha China Department of Microbiology, Fourth Military Medical University, Xi'an 710032, China. School of Materials Science and Engineering, Zhejiang University, Hangzhou 310058, China; Shanxi-Zheda Institute of Advanced Materials and Chemical Engineering, Taiyuan 030001, China College of Environmental Science and Engineering, Peking University, The Key Laboratory of Water and Sediment Sciences, Ministry of Education, Beijing 100871, China, and School of Natural Resources & Environment, University of Michigan, Ann Arbor, Michigan 48109 Center of Engineering Technology Research for Biomedical Optical Instrument, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, P. R. China Key Laboratory of Nutrition and Metabolism (L.S., Z.Y., H.L., X.Y., Q.Q., J.W., A.P., Y.L., X.L.), Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Graduate School of the Chinese Academy of Sciences, 200031 Shanghai, China State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Materials Science and Engineering Donghua University Shanghai 201620 China Institute of Atomic and Molecular Physics; Jilin University; Changchun 130012; China Science Island Branch of Graduate School, University of Science and Technology of China, Hefei 230031, China; Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, China Henan Key Laboratory of Polyoxometalate Chemistry, College of Chemistry and Chemical Engineering, Henan University, Kaifeng, 475004, China School of Mechanical and Aerospace Engineering, Jilin University, Changchun 130000, China Department of Molecular, Cellular and Developmental Biology, and Interdepartmental Graduate Program of Biochemistry and Molecular Biology, University of California, Santa Barbara, CA 93106 State Key Laboratory of Space Power Technology Shanghai Institute of Space Power Sources Shanghai 200245 P. R. China Institute of Neurobiology Xi’an Jiaotong University Health Science Center Xi’an Shaanxi China Merck & Co., Inc. Kenilworth NJ USA College of Life Sciences, The Institute for Advanced Studies, Wuhan University, 430072 Wuhan, China; c School of Biotechnology and Food Engineering , Hefei University of Technology , Hefei, China From the Department of Physiology (Z.T., Y.L., K.U., D.M., Y.F., A.S.G., A.W.C., M.L.) and Biotechnology and Biomedical Engineering Center (Z.T., A.S.G.), Medical College of Wisconsin, Milwaukee; Department of Biomedical Engineering (Z.T.), Xi'an Jiaotong University, Shanxi, People’s Republic of China; and the Department of Nephrology (Y.F., X.D.), Zhongshan Hospital, Fudan University, Shanghai, People’s Republic of China. 1Institute of Applied Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, China Department of orthopedics, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College Department of orthopedics State Key Laboratory of Metastable Materials Science & Technology and Key Laboratory for Microstructural Material Physics of Hebei Province, School of Science, Yanshan University, Qinhuangdao 066004, China Ames Laboratory 5 , Ames, Iowa 50011, USA Department of Orthopaedics, Shanghai Changzheng Hospital, Shanghai 200003, PR China. International School of Materials Science and Engineering (ISMSE), State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Wuhan 430070, China School of Physics and Technology, and the Key Laboratory of Artificial Micro/Nano structures of Ministry of Education, Wuhan University, Wuhan 430072, China School of Materials Science and Engineering, Anhui University of Science and Technology, Huainan 232001, China Lanzhou Medical College, Lanzhou 730000. Institute of Loess Plateau, Shanxi University, Taiyuan, 030006, China Department of Anesthesiology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China State Key Laboratory of Metastable Materials Science & Technology and Hebei Key Laboratory of Microstructural Material Physics; School of Science; Yanshan University; Qinhuangdao; China School of Ocean Engineering, Harbin Institute of Technology, Weihai 264209, China Department of Anesthesiology, The 4th People’s Hospital of Guiyang, Guiyang, China Center of Forensic Expertise Affiliated Hospital of Zunyi Medical University Zunyi Guizhou China School of Chemistry and Chemical Engineering, Central South University, Changsha 410083, Hunan, China Department of Vascular Surgery, The First Affiliated Hospital, Sun Yat-sen University. Institute of High-Performance Computing, Agency for Science, Technology and Research, Singapore The Guyuan Museum of Ningxia, Guyuan 756000, P. R. China; Key Laboratory of Macromolecular Science of Shaanxi Province, College of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi'an 710062, P. R. China; The State Key Laboratory of Rare Earth Materials Chemistry and Applications, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, P. R. China Department of Chemistry, University of Colorado at Denver, Denver, Colorado 80217, United States Institute of Neurobiology, Department of Human Anatomy and Histoembryology, Medicine College, Xi’an Jiaotong University, Xi’an, Shaanxi, China Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Brainnetome Center & National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China; School of Artificial Intelligence, University of Chinese Academy of Sciences, Beijing 100049, China; Center for Excellence in Brain Science and Intelligence Technology, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China. Electronic address: yliu@nlpr.ia.ac.cn. Institute of High Performance Computing, ASTAR College of Environmental Sciences, Peking University, Beijing 100871, China. yongliu@pku.edu.cn Department of Internal Medicine, Gene Therapy Program, Department of Biochemistry and Molecular Biology, and Department of Obstetrics and Gynecology, University of Arkansas for Medical Sciences, 4301 West Markham Street, Little Rock, Arkansas 72205 Key Laboratory of Nutrition and MetabolismInstitute for Nutritional SciencesShanghai Institutes for Biological Sciences (SIBS) Shanghai China State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian National Laboratory for Clean Energy, Dalian 116023, China Key Laboratory of Nutrition and Metabolism (Y.L.), Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China Key Laboratory of Embryo Development and Reproductive Regulation of Anhui Province, College of Biological and Food Engineering, Fuyang Teachers College, Fuyang City, Anhui Province 236037, China. State Key Laboratory of Nuclear Physics and Technology, School of Physics, Peking University, Beijing 100871, P. R. China Key Laboratory of Environmentally Friendly Chemistry and Application of Ministry of Education, College of Chemistry, Xiangtan University, Xiangtan, 411105, China State Key Laboratory of Silicon Materials; School of Materials Science and Engineering; Zhejiang University; Hangzhou 310027; China Department of Ultrasound, Beijing Shijitan Hospital, Capital Medical University, Beijing, China Laboratory of Nanoscale Biosensing and Bioimaging, School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, Zhejiang 325027, China Institute of Plant Protection, Hunan Academy of Agricultural Sciences, Changsha, PR China Department of Otolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China State Key Laboratory for Powder Metallurgy & School of Metallurgy and Environment Central South University Changsha Hunan 410083 P. R. China School of Food Engineering Anhui Science and Technology University Fengyang China Department of Endoscopy, Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Beijing, China Department of Orthopaedics The Fifth Hospital of Harbin Harbin China Wenzhou Institute, University of Chinese Academy of Sciences, Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), Wenzhou, Zhejiang, China Celgene Corporation Summit New Jersey USA Department of General Surgery, Third Xiangya Hospital, Central South University, Changsha, Hunan, China. Institute of Plant Protection, Hunan Academy of Agricultural Sciences, Changsha 410125, China Center for Drug Discovery, Georgetown University Medical Center, Research Building EP07, 3970 Reservoir Road, NW, Washington, D.C. 20057, United States Key Laboratory of Integrated Management of the Pests and Diseases on Horticultural Crops in Hunan Province, Institute of Plant Protection, Hunan Academy of Agriculture Sciences, Changsha 410125, China; Long Ping Branch, Graduate School of Hunan University, Changsha 410125, China Key Lab of Artificial Micro‐ and Nano‐Structures of Ministry of Education of China School of Physics and Technology Wuhan University Wuhan Hubei 430072 P. R. China Department of Otolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, PR China Department of Anatomy, National and Regional Engineering Laboratory of Tissue Engineering, State and Local Joint Engineering Laboratory for Vascular Implants, Key Lab for Biomechanics and Tissue Engineering of Chongqing, Third Military Medical University, Chongqing 400038, China. Department of Radiation Oncology, Shanghai General Hospital, Shanghai Jiaotong University, Shanghai Chengdu Public Health Clinical Center, Chengdu, China School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan 430074, China School of Public Health, Nanchang University, Nanchang, Jiangxi, China Department of Pediatrics Sun Yat‐Sen Memorial Hospital, Sun Yat‐Sen University Guangzhou Guangdong Province China; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Sun Yat‐Sen Memorial Hospital, Sun Yat‐Sen University Guangzhou Guangdong Province China Intensive Care Unit, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou 363000, Fujian, China. Hubei Key Laboratory of Cell Homeostasis College of Life Sciences Institute for Advanced Studies Wuhan University Wuhan 430072 P. R. China Brainnetome Center and National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing, China; Center for Excellence in Brain Science and Intelligence Technology, Institute of Automation, Chinese Academy of Sciences, Beijing, China; University of Chinese Academy of Sciences, Beijing, China; School of Artificial Intelligence, Beijing University of Posts and Telecommunications, Beijing, China. Electronic address: janemengzhang@vip.163.com. Department of Vascular Surgery, Affiliated Hospital of Luzhou Medical College Department of Cardiology, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Cardiovascular Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, China; The George Institute for Global Health, Sydney, Australia Institute of Neurobiology, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi 710061, P.R. China State Key Laboratory of Powder Metallurgy, Central South University, Changsha 410083, P. R. China School of Physics, Wuhan University, Wuhan 430072, P.R. China Department of Hematology, The First Affiliated Hospital of Soochow University, Jiangsu Institute of Hematology, Soochow National Clinical Research Center for Hematologic Diseases, Collaborative Innovation Center of Hematology, Ministry of Health Key Laboratory of Thrombosis and Hemostasis Suzhou 215000, Jiangsu Province, China. Key Laboratory of Nanosystem and Hierarchical Fabrication, Chinese Academy of Sciences National Center for Nanoscience and Technology No. 11, Beiyitiao, Zhongguancun Beijing 100190 P. R. China School of Life and Pharmaceutical Sciences, Dalian University of Technology, Panjin, Liao Ning, China Key Laboratory for Heavy Metal Pollution Control and Reutilization, School of Environment and Energy, Peking University Shenzhen Graduate School, Shenzhen, People’s Republic of China Division of Population Health, National Center for Chronic Disease Prevention and Health Promotion, CDC Departments of Obstetrics and Gynecology, University of Arkansas for Medical Sciences College of Bioengineering, Chongqing University, Chongqing 400044, China; Institute of Toxicology, College of Preventive Medicine, Third Military Medical University, Chongqing 400038, China National Tobacco Genetic Engineering Research Center Yunnan Academy of Tobacco Agricultural Sciences Kunming Yunnan China Department of General Surgery, Changzhou Hospital of Traditional Chinese Medicine Nanjing University of Chinese Medicine, Changzhou, Jiangsu 213004, China Department of Dermatology and STD, The Third Central Hospital of Tianjin, Tianjin, China. Brainnetome Center, National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing, China Department of Neurosurgery and Clinical Research Center for Refractory Epilepsy of Shaanxi Province, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China; University of Electronic Science and Technology of China (UESTC) Department of Neurology the Second Affiliated Hospital of Chongqing Medical University Chongqing China Department of Magnetic Resonance Imaging, Affiliated Chinese Traditional Medicine Hospital, Southwest Medical University, Luzhou 646000, China Department of Orthopaedic Surgery Peking Union Medical College Hospital Peking Union Medical College Beijing China College of Life Sciences, Institute for Advanced Studies, Wuhan University, Wuhan, China Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China School of Materials Science and Engineering Henan University of Science and Technology Luoyang 471023 China School of Chemical Engineering and Technology Collaborative Innovation Center of Chemical Science and Chemical Engineering (Tianjin) Tianjin University Tianjin 300072 China School of Chemistry and Chemical Engineering Tianjin University of Technology Tianjin PR China School of Materials Science and Engineering; Qingdao University of Science and Technology; Qingdao 266042; P. R. China Jun'an Disinfection Research Center 20 East Str. Fengtai District 100071 Beijing People's Republic of China Department of Chemistry and Chemical Biology, RutgersThe State University of New Jersey, Piscataway, New Jersey 08854 Department of Urology Sperm Development and Genetics Laboratory Renji Hospital Shanghai Human Sperm Bank Shanghai Institute of Andrology Shanghai Jiao Tong University School of Medicine Shanghai P. R. China Clinical Laboratory Shengjing Hospital of China Medical University Shenyang 110004 PR China Ultrasonography, Beijing Shijitan Hospital, Capital Medical University, Beijing, People’s Republic of China. Department of endoscopy, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China School of Civil and Surveying & Mapping Engineering, Jiangxi University of Science and Technology, Ganzhou, Jiangxi, People’s Republic of China State Key Laboratory of Catalysis, Dalian National Laboratory for Clean Energy, Collaborative Innovation Center of Chemistry for Energy Materials (iChEM), Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Zhongshan Road 457, Dalian 116023, P. R. China College of Chemistry and Chemical Engineering, Henan University, Kaifeng 475004, China Department of Cardiovascular Surgery, West China Hospital, Sichuan University, Chengdu 610041, China. Department of Otorhinolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha 410008, China. College of Plant Protection, Shandong Agricultural University, No. 61, Daizong Road, Taian, Shandong 271018, China Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, China; Department of Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, China Hunan Province Engineering Technology Research Centre of Uranium Tailings Treatment Technology, Hengyang 421001, China CAS Key Laboratory of Quantum Information, School of Physical Sciences,University of Science and Technology of China, Hefei 230026, People’s Republic of China; CAS Center For Excellence in Quantum Information and Quantum Physics, University of Science and Technology of China, Hefei 230026, People’s Republic of China Department of Biochemistry and Molecular Biology, School of Basic Medicine and the Collaborative Innovation Center for Brain Science Tongji Medical College, Huazhong University of Science and Technology Wuhan Hubei China Joint NTU-UBC Research Centre of Excellence in Active Living for the Elderly, Nanyang Technological University , Singapore 639798, Singapore 1Department of In Vivo Pharmacology, BeiGene (Beijing) Co., Ltd., Beijing, P.R. China. School of Biotechnology and Food Engineering, Hefei University of Technology, Hefei 230009, China Exploration and Development Research Institute of Daqing Oilfield Co. Ltd., Daqing 163453, China; Heilongjiang Provincial Key Laboratory of Reservoir Physics & Fluid Mechanics in Porous Medium, Daqing 163453, China Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences,Chinese Academy of Sciences, University of Chinese Academy of Sciences,Shanghai,China Department of Oncology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, P.R. China Systems Biology & Medicine Center for Complex Diseases Affiliated Hospital of Qingdao University Qingdao China Key Laboratory of Artificial Micro- and Nano-structures of Ministry of Education and School of Physics and Technology, Wuhan University, Wuhan, Hubei 430072, China School of Materials Science and Engineering, Clemson University, Clemson, South Carolina 29634 School of Materials Science and Engineering; Harbin Institute of Technology; Harbin; China; National Key Laboratory for Precision Hot Processing of Metals Department of Orthopaedic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College Jiangxi Agricultural University College of Agronomy, , Nanchang, Jiangxi 330045, China Center of Systems Molecular Medicine, Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin Department of Cardiology, The Fourth Central Hospital of Tianjin, Tianjin, China. Department of Education, Beijing Children’s Hospital, Capital Medical University, Beijing, China Institute of Plant Protection Hunan Academy of Agricultural Sciences Changsha China Physiology Department, College of Integrated Chinese and Western Medicine, Anhui University of Chinese Medicine, Hefei, Anhui 230038, China The University of Aizu, Tsuruga, Ikki-machi, Aizuwakamatsu, Fukushima 965-8580, Japan Authors' Affiliations: 1Joint Laboratory of Apoptosis and Cancer Biology, State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences; 2Graduate University of Chinese Academy of Sciences, Beijing; and 3Tianjin Key Laboratory of Protein Sciences, College of Life Sciences, Nankai University, Tianjin, China; Authors' Affiliations: 1Joint Laboratory of Apoptosis and Cancer Biology, State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences; 2Graduate University of Chinese Academy of Sciences, Beijing; and 3Tianjin Key Laboratory of Protein Sciences, College of Life Sciences, Nankai University, Tianjin, China Department of Otolaryngology‐Head and Neck Surgery The Xiangya Hospital, Central South University Changsha China; Otolaryngology Major Disease Research Key Laboratory of Hunan Province Changsha China; Clinical Research Center for Pharyngolaryngeal Diseases and Voice Disorders in Hunan Province Changsha China; National Clinical Research Center for Geriatric Disorders XiangYa Hospital Changsha China CAS Key Laboratory of Nanosystem and Hierarchical Fabrication; CAS Center for Excellence in Nanoscience; National Center for Nanoscience and Technology; Zhongguancun; P. R. China College of Plant Protection, Shandong Agricultural University, Tai'an 271018, Shandong, China. liuyong@sdau.edu.cn Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, and Graduate School of the Chinese Academy of Sciences, Shanghai 200031, China. Key Laboratory of Synthetic and Biological Colloids Ministry of Education School of Chemical and Material Engineering Jiangnan University Wuxi 214122 China Key Laboratory of Systems Biology, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Graduate School of the Chinese Academy of Sciences, Shanghai, China South China Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Guangzhou, Guangdong, PR China; State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian 116023, China Yan’an Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China Key Laboratory of Synthetic and Biological Colloids Ministry of Education School of Chemical and Material Engineering Jiangnan University Wuxi 214122 P. R. China Hematologin Laboratory,Department of Pediatrics,Sun Yat-sen Memorial Hospital,Sun Yat-sen University,Guangzhou 510120,Guangdong Province, China,E-mail: leon972879@126.com. State Key Laboratory of Biocatalysis and Enzyme Engineering School of Life Science Hubei University Wuhan 430062 China Department of Analytical Sciences, MRL Merck & Co., Inc. Rahway New Jersey USA College of Chemistry and Chemical Engineering, Henan University, Kaifeng 475004, PR China Institute of High‐Performance Computing, Agency for Science, Technology, and Research Singapore Department of Rehabilitation Medicine The First Affiliated Hospital of Dalian Medical University Dalian China; Institute (College) of Integrative Medicine Dalian Medical University Dalian China Burnet Institute incorporating the Austin Research Institute, Heidelberg, Australia; Key Laboratory for Silviculture and Conservation, Ministry of Education, Beijing Forestry University , Beijing 100083 , China; Research Center of Deciduous Oaks, Beijing Forestry University , Beijing 100083 , China; National Innovation Alliance of Valuable Deciduous Tree Industry, Beijing Forestry University , Beijing 100083 , China Department of Neurosurgery, the First Affiliated Hospital of Xi’an Jiaotong University Research & Development Center of Biorational Pesticide, Key Laboratory of Plant Protection Resources and Pest Management of Ministry of Education and ‡Shaanxi Research Center of Biopesticide Engineering & Technology, Northwest A&F University, Yangling 712100, China Center of Systems Molecular Medicine, Department of Physiology, Institute of Fluorescent Probes for Biological Imaging; School of Chemistry and Chemical Engineering; School of Biological Science and Technology; University of Jinan; Jinan National Key Laboratory of Special Vehicle Design and Manufacturing Integration Technology, Baotou 014030, China Air Force Medical Center of Chinese PLA, Beijing, China Department of Neurology, The First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan 610500, P.R. China Department of Cancer Immunotherapeutics and Tumor Immunology and Institute of High Performance Computing (IHPC), Agency for Science, Technology and Research (A*STAR), 1 Fusionopolis Way, #16-16 Connexis, Singapore 138632, Singapore Genetic Diagnosis Centre Central Laboratory Ministry of Education First Hospital Jilin University Changchun China Fisheries College, Guangdong Ocean University, Zhanjiang 524088, China; Guangdong Research Center on Reproductive Control and Breeding Technology of Indigenous Valuable Fish Species, Guangdong Provincial Engineering Laboratory for Mariculture Organism Breeding, Guangdong Provincial Key Laboratory of Aquatic Animal Disease Control and Healthy Culture, Zhanjiang 524088, China Department of Dermatology, Shaanxi Provincial Hospital of Traditional Chinese Medicine, Xi'an, Shaanxi 710003, P.R. China Department of Atmospheric, Oceanic, and Space Sciences, University of Michigan, Ann Arbor, Michigan 48109-2143, and Department of Chemistry, University of Michigan, Ann Arbor, Michigan 48109-1055 Institute of Neurobiology Department of Human Anatomy and Histoembryology Xi'an Jiaotong University College of Medicine Xi'an China *Department of Neurology, Xinqiao Hospital, Third Military Medical University, Chongqing 40037, China; Department of Clinical Laboratory, Shengjing Hospital of China Medical University, Shenyang, People’s Republic of China Hunan Plant Protection Institute, Hunan Academy of Agricultural Sciences, Changsha, Hunan, China School of Artificial Intelligence, Beijing University of Posts and Telecommunications, Beijing, China Hunan Plant Protection Institute Hunan Academy of Agricultural Science Changsha China Department of Orthopaedics, the 9th People's Hospital of Wuxi, Wuxi Jiangsu, 214062, P.R.China. Department of Chemistry, University of Colorado-Denver, Denver, Colorado 80217, United States Qingdao Traditional Chinese Medicine Hospital (Qingdao Hiser Hospital), Qingdao University, China Laboratory Medicine, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, China Institute of Neurobiology, School of Basic Medical Sciences Health Science Center, Xi'an Jiaotong University Xi'an China Department of Chemistry, University of Waterloo, 200 University Avenue West, Waterloo, Ontario, Canada N2L 3G1 Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, Beijing Advanced Innovation Centre for Biomedical Engineering, School of Engineering Medicine, School of Biological Science and Medical Engineering, Beihang University, No.37 Xueyuan Road, Haidian District, Beijing 100083, P. R. China Department of Laboratory Medicine, Shengjing Hospital of China Medical University, Liaoning Clinical Research Center for Laboratory Medicine, Shenyang, China Engineering Research Center of Bio‐process, Ministry of Education Hefei University of Technology Hefei People's Republic of China; School of Food and Biological Engineering Hefei University of Technology Hefei People's Republic of China School of Materials Science and Engineering, Henan University of Science and Technology, Luoyang 471023, P. R. China Agricultural Information Institutes of Science and Technology, Shanghai Academy of Agricultural Sciences, Shanghai 201403, China Institute of Fluorescent Probes for Biological Imaging, School of Chemistry and Chemical Engineering, School of Biological Science and Technology, University of Jinan, Jinan, Shandong 250022, P.R. China Department of Cardiology, Liaocheng People's Hospital, Liaocheng Collaborative Innovation Center of Tumor Marker Detection Technology, Equipment and Diagnosis-Therapy Integration in Universities of Shandong, Shandong Province Key Laboratory of Detection Technology for Tumor Makers, School of Chemistry and Chemical Engineering, Linyi University, Linyi, 276005, China Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China; and Department of Cardiovascular and Thoracic Surgery Children's Heart Center, The Second Affiliated Hospital & Yuying Children's Hospital, Institute of Cardiovascular Development and Translational Medicine, Wenzhou Medical University Wenzhou P.R. China School of Psychology, Southwest University, Chongqing 400715, China; Key Laboratory of Cognition and Personality (Ministry of Education), Southwest University, Chongqing 400715, China Department of Cardiology, The Third Affiliated Hospital of Sun Yat-sen University State Key Laboratory of New Ceramics and Fine Processing, Department of Materials Science and Engineering, Tsinghua University, Beijing 100084, China Institute of Advanced Materials for Nano-bio Applications, School of Ophthalmology and Optometry, Wenzhou Medical University, 270 Xueyuan Xi Road, Wenzhou, Zhejiang Province 325027, China State Key Laboratory of Fine Chemicals, Research and Development Center of Membrane Science and Technology, School of Chemical Engineering, Dalian University of Technology, Dalian 116024, Liaoning, China Beijing Engineering Research Center for BioNanotechnology and CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety CAS Center for Excellence in Nanoscience National Center for NanoScience and Technology Beijing 100190 P. R. China; University of Chinese Academy of Sciences Beijing 100049 P. R. China School of Materials Science and Engineering Qingdao University of Science and Technology Qingdao Shandong 266042 China Laboratory of Advanced Perception on Robotics and Intelligent Learning, College of Control Science and Engineering, Zhejiang University, Hangzhou, Zhejiang, China School of Life and Pharmaceutical Sciences, Dalian University of Technology, Panjin 124221, China Department of Orthopaedic Surgery, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Brainnetome Center, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China; University of Chinese Academy of Sciences, Beijing 100049, China; CAS Center for Excellence in Brain Science, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China School of Life Science and Medicine; Dalian University of Technology; Panjin 124221; China Hefei Institute of Physical Science, Chinese Academy of Sciences, Hefei 230036, P. R China; University of Science and Technology of China, Hefei 230036, P. R China Hefei Institute of Physical Science, Chinese Academy of Sciences, Hefei 230036, China; Wan Jiang New Industry Technology Development Center, Tongling 244000, China Department of Radiation Oncology Shanghai General Hospital Shanghai Jiao Tong University School of Medicine Shanghai China Department of Orthopaedic Surgery; The First Affiliated Hospital of Soochow University; Suzhou; PR China; Department of Orthopaedic Surgery Department of Laboratory Medicine, Nanjing Drum Tower Hospital, Nanjing University Medical School Nanjing, Jiangsu, China. School of Chemistry and Chemical Engineering, State Key Laboratory of Metal Matrix Composites, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, P. R. China Thermo Fisher Scientific (China) Co., Ltd. China Cell Culture and Bioprocess Engineering Lab, School of Pharmacy, Shanghai Jiao Tong University, China Institute of Applied Technology; Hefei Institutes of Physical Science; Chinese Academy of Sciences; Hefei; PR China Institut de Science des Matériaux de Mulhouse, LRC 7228 CNRS, Université de Haute Alsace, 3 rue Alfred Werner, 68093 Mulhouse, France, State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian 116023, China, Central Facility for Advanced Microscopy and Microanalysis, University of California, Riverside, California 92521, and Laboratoire Catalyse et Spectrochimie, ENSICAEN, Université de Caen, CNRS, 6 boulevard du Maréchal Juin, 14050... Guizhou Center for Disease Control and Prevention, Guiyang, China. Central Research Lab, The Affiliated Drum Tower Hospital of Nanjing University Medical School, 321 Zhongshan Rd., Nanjing 210008, China School of Life Science and Medicine Dalian University of Technology Panjin 124221 China Department of Research Platform, Mudanjiang Medical University, Mudanjiang, Heilongjiang 157011, P.R. China From the Department of Physiology, Center of Systems Molecular Medicine (M.K.M., E.Y.L., A.M.G., P.L., A.S.G., M.L., Y.L.), Medical College of Wisconsin, Milwaukee Chemical Synthesis and Pollution Control Key Laboratory of Sichuan Province, College of Chemistry & Chemical Engineering, China West Normal University, Nanchong 637009, China, and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China Department of Neurology, Lu’an Affiliated Hospital of Anhui Medical University Institute of Advanced Materials for Nano-Bio Applications (IAMNBA), School of Ophthalmology & Optometry & Eye Hospital, Wenzhou Medical College, 270 Xueyuan West Road, Wenzhou, Zhejiang 325027, China Key Laboratory of Artificial Micro- and Nano-structures of Ministry of Education; School of Physics and Technology; Wuhan University; Wuhan; P. R. China Department of Materials Science and Engineering National University of Singapore Singapore 117575 Singapore Department of Cardiovascular Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China (mainland) Key Lab of Artificial Micro‐ and Nano‐Structures of Ministry of Education of China School of Physics and Technology Hubei Luojia Laboratory Wuhan University Wuhan 430072 China Department of Chemistry, University of Waterloo, 200 University Avenue West, Waterloo, ON, Canada N2L 3G1 Laboratory of Molecular Cell Signaling, Department of Developmental Biochemistry, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY, USA. Department of Neurology, Xinqiao Hospital, The Second Affiliated Hospital , The Third Military Medical University , Chongqing , China State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian National Laboratory for Clean Energy, Dalian116023, China Gaoling School of Artificial Intelligence, Renmin University of China, Beijing, China Plant Protection College, Shandong Agricultural University, 271018 Taian, China; Department of Biointeractions and Crop Protection, Rothamsted Research, Harpenden AL5 2JQ, U.K. Department of Orthopedics, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China College of Pharmaceutical Sciences, Zhejiang University of Technology Platform Management Division, Scientific Research Division of Mudanjiang Medical College, Mudanjiang, PR, China Department of Orthopaedic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College , Beijing , China Youtu Lab, Tencent, China Guangdong Provincial Key Laboratory of Luminescence from Molecular Aggregates, South China University of Technology, Guangzhou 510640, China State Key Laboratory for Infectious Diseases Prevention and Control, National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Xuan Wu District, Beijing 100050, China. AECC-Beijing Institute of Aeronautical Materials; No. 8 Hangcai Avenue; Huanshancun; Haidian District; 100095 Beijing 4Anhui Province Key Laboratory of Embryo Development and Reproductive Regulation, Anhui Province Key Laboratory of Environmental Hormone and Reproduction, Fuyang Normal University, Fuyang, Anhui, People’s Republic of China Harbor-UCLA Medical Center, Department of Medicine, Division of Gastroenterology & Hepatology, Torrance, CA, USA Department of Chemistry, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, State Key Laboratory of Molecular Engineering of Polymers, Laboratory of Advanced Materials, Fudan University, Shanghai, 200433, China State Key Laboratory of Catalysis Dalian Institute of, Chemical Physics Chinese Academy of Sciences Dalian 116023 P. R. China The MOE Key Laboratory for Standardization of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, 1200 Cai Lun Road, Shanghai 201210, China, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhong Shan Road, Dalian, 116023, China, and Clinical Research Centre, Sarawak General Hospital, Kuching, 93000, Malaysia Division of Population Health, Centers for Disease Control and Prevention, Atlanta, GA Brainnetome Center, Institute of Automation, Chinese Academy of Sciences, Beijing, China; National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing, China; CAS Center for Excellence in Brain Science and Intelligence Technology, Institute of Automation, Chinese Academy of Sciences, Beijing, China; School of Artificial Intelligence, University of Chinese Academy of Sciences, Beijing, China School of Materials Science and Engineering, Harbin Institute of Technology, 150001 Harbin, People's Republic of China; National Key Laboratory for Precision Hot Processing of Metals, Harbin Institute of Technology, 150001 Harbin, People's Republic of China Department of Analytical Research & Development, Merck & Co., Inc., Rahway, New Jersey 07065, United States Analytical Research and Development, MRL, Merck & Co., Inc., P.O. Box 2000, Rahway, New Jersey 07065, United States Department of Gastroenterological Surgery, Sichuan University, Sichuan Province, China. The Academy of Environmental Protection and Safety Engineering, University of South China, Hengyang 421001, P. R. China Department of Orthopaedic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China State Key Laboratory of Powder Metallurgy Central South University Changsha Hunan China Chemical Synthesis and Pollution Control Key Laboratory of Sichuan Province, College of Chemistry and Chemical Engineering, China West Normal University, No. 1, Shida Road, Nanchong 637002, P. R. China Department of Physiology; Medical College of Wisconsin; Milwaukee Wisconsin Department of Vascular Surgery, Affiliated Hospital of Luzhou Medical College No. 25, Taiping Street Jiang Yang District Luzhou, Sichuan, China. State Key Laboratory of Silicon Materials and Department of Materials Science and Engineering, Department of Chemistry and Center of Analysis and Measurement, International Center for New-Structured Materials (ICNSM), and Laboratory of New-Structured Materials, Department of Materials Science and Engineering, Zhejiang University, Hangzhou 310027, P.R. China Department of Process and Analytical Chemistry and Department of Structural Chemistry, Merck Research Laboratories, Merck & Co., Inc., 07065, Rahway, NJ, USA Department of Anesthesiology, Traditional Chinese Medicine Hospital Affiliated to Xinjiang Medical University, Urumqi, Xinjiang 830099, P.R. China Institute of Advanced Materials for Nano-Bio Applications, School of Ophthalmology & Optometry, and Eye Hospital, Wenzhou Medical College, China Department of Gastroenterological Surgery West China Hospital, Sichuan University Chengdu China Department of Orthopaedic Surgery, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences State Key Laboratory of Powder Metallurgy, Central South University, Changsha 410083, China Department of Endoscopy, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. University of Electronic Science and Technology of China, MOEMIL Laboratory, School of Optoelectronic Information, No. 4, Section 2, North Jianshe Road, Chengdu 610054, China College of Plant Protection Shandong Agricultural University Taian Shandong China Public Health Clinical Center of Chengdu, Chengdu, China Beijing National Laboratory for Molecular Sciences, Laboratory of Polymer Physics and Chemistry, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China; University of Chinese Academy of Sciences, Beijing 100049, P. R. China Department of Neurosurgery The Affiliated Brain Hospital of Nanjing Medical University Nanjing Jiangsu China State Key Laboratory for Powder Metallurgy; Powder Metallurgy Research Institute; Central South University; Changsha 410083; China College of Chemistry and Materials Science, Sichuan Normal University, Chengdu 610066, China; Key Laboratory of Treatment for Special Wastewater of Sichuan Province Higher Education System, Sichuan, Chengdu 610066, China State Key Laboratory of Marine Pollution, Department of Chemistry, City University of Hong Kong, Hong Kong, China *Department of Microbiology, Immunology and Molecular Genetics, School of Medicine, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229; and; †Department of Otolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China Exploration and Development Research Institute of Daqing Oilfield Co. Ltd, Daqing163001, China; Heilongjiang Provincial Key Laboratory of Reservoir Physics & Fluid Mechanics in Porous Medium, Daqing163001, China Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, 116023, China Division of Population Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA, USA Institute of Toxicology College of Preventive Medicine Third Military Medical University Chongqing 400038 P.R. China Institute of Polymer Materials, School of Materials Science and Engineering, Jiangsu University, 301 Xuefu Road, Zhenjiang 212013, China Faculty of Chinese Medicine, Macau University of Science and Technology, Taipa, Macau, People’s Republic of China; State Key Laboratory of Quality Research in Chinese Medicine (Macau University of Science and Technology), Taipa, Macau, People’s Republic of China; Drug Discovery Research Center, Southwest Medical University, Luzhou, Sichuan, People's Republic of China; Laboratory for Cardiovascular Pharmacology of the Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan, People’s Republic of China Key Laboratory for Micro-Nano Physics and Technology of Hunan Province, School of Physics and Electronics, Hunan University, Changsha 410082, People’s Republic of China Institute of Mental Health, Second Xiangya Hospital, Central South University, Changsha 410011, China. Department of Pathology,Jiangxi Provincial People's Hospital, Nanchang 330006, Jiangxi Province, China. Department of Orthopaedic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College , Beijing , China School of Resources & Environment and Key Laboratory of Poyang Lake Environment and Resource Utilization Ministry of Education Nanchang University Nanchang 330031 P.R. China Nanyang Technological University , Singapore 639798, Singapore Department of Orthorpaedic Surgery, Peking Union Medical College Hospital, Beijing 100730, P.R. China College of Chemistry and Materials Science, Sichuan Normal University, Chengdu 610066, P. R. China; Laboratory of Environmental Technology, INET, Tsinghua University, Beijing 100084, P. R. China School of Medicine South China University of Technology; Department of Cardiology, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University; Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University State Key Laboratory of Modern Optical Instrumentation Zhejiang University Hangzhou 310027 China Department of Burn and Plastic Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China. Key Laboratory of Light weight and high strength structural materials of Jiang xi Province, Nanchang University, Nanchang 330031, People’s Republic of China Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Academy of Medical Sciences, Guangdong General Hospital School of Material Science and Engineering, Qingdao University of Science and Technology, Qingdao, Shandong 266042, China Chinese Academy of Sciences 2 State Key Lab of Molecular Reaction Dynamics, Dalian Institute of Chemical Physics, , Dalian, China Department of Burns and Plastic Surgery West China Hospital Sichuan University Chengdu Sichuan China Southwestern Institute of Physics 1 , P.O. Box 432, Chengdu 610041, People's Republic of China Department of Intensive Care Unit, West China Hospital of Sichuan University, Chengdu, China South China Advanced Institute for Soft Matter Science and Technology School of Emergent Soft Matter South China University of Technology Guangzhou 510640 China; Guangdong Provincial Key Laboratory of Functional and Intelligent Hybrid Materials and Devices South China University of Technology Guangzhou 510640 China School of Chemistry and Chemical Engineering, Tianjin University of Technology, Tianjin, P.R. China Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences and Sichuan Academy of Agricultural Sciences Chengdu Sichuan P.R. China; Institute of Plant Protection, Sichuan Academy of Agricultural Sciences Chengdu China; Key Laboratory of Integrated Pest Management on Crops in Southwest, Ministry of Agriculture and Rural Affairs Chengdu China From the Department of Physiology, Center of Systems Molecular Medicine, Medical College of Wisconsin, Milwaukee (M.A.B., F.W., Y.L., A.J.K., A.M.G., K.U., H.X., D.W., Y.K., M.L.) Anhui Province Key Laboratory of Embryo Development and Reproductive Regulation, Anhui Province Key Laboratory of Environmental Hormone and Reproduction Fuyang Normal University Fuyang Anhui China; Department of Veterinary and Animal Sciences University of Massachusetts Amherst Massachusetts USA National Clinical Research Center for Mental Disorders, and Department of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, People's Republic of China.; Hunan Key Laboratory of Psychiatry and Mental Health, Changsha, People's Republic of China.; China National Technology Institute on Mental Disorders, Changsha, People's Republic of China. College of Medicine and Nursing, Shandong Provincial Engineering Laboratory of Novel Pharmaceutical Excipients, Sustained and Controlled Release Preparations, Dezhou University, China College of Chemistry and Materials Science, Sichuan Normal University, Chengdu, Sichuan 610068, P. R. China Sun Yet-Sen University, Guangzhou, China. Department of Intensive Care Unit, Shenzhen Hospital, Southern Medical University, Shenzhen, China Institute of Liver Diseases, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China; School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China Department of Neurology Mayo Clinic Rochester Minnesota Anhui Provincial Engineering Technology Research Center for Biomedical Optical Instrument, Anhui Provincial Engineering Laboratory for Medical Optical Diagnosis &Treatment Technology and Instrument, Anhui Institute of Optics and Fine Mechanics, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, 230031, China; University of Science and Technology of China, Hefei, 230026, China; Wanjiang Center for Development of Emerging Industrial Technology, Tongling, 244000, China School of Computing, National University of Singapore (NUS), Singapore, Singapore National Center for Nanoscience and Technology, Beijing 100190, People’s Republic of China State Key Laboratory of Hybrid Rice and Institute of Plant Protection, Hunan Academy of Agricultural Sciences, Changsha, China; Long Ping Branch, Hunan University, Changsha, China Institute of Neurobiology, School of Basic Medical Sciences, Xi’an Jiaotong University Health Science Center, Xi’an, Shaanxi 710061, P.R.China Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and University of the Chinese Academy of Sciences, Shanghai, China Department of Radiology, The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Luzhou, China Department of Endoscopy, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China Department of Emergency, First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi, China Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China High Magnetic Field Laboratory, CAS Key Laboratory of High Magnetic Field and Ion Beam Physical Biology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, China; Hefei Institutes of Physical Science (Branch of Graduate School), University of Science and Technology of China, Hefei 230026, China Department of Chemistry, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Laboratory of Advanced Materials, iChEM (Collaborative Innovation Center of Chemistry for Energy Materials), Fudan University, Shanghai 200433, China; Department of Chemistry, University of California, Berkeley, California 94720, United States Department of Orthopedic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences , Beijing 100730 , China Department of Orthopaedics, Xiehe Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022. lw7812@21cn.com School of Chemical Engineering, Sichuan University, Chengdu 610065, China Laboratory of Pharmaceutical Resource Discovery, Dalian Institute of Chemical Physics, Chinese Academy of Sciences; Graduate School of the Chinese Academy of Sciences State Key Laboratory of Organic Electronics and Information Displays & Institute of Advanced Materials (IAM), Nanjing University of Posts & Telecommunications, 9 Wenyuan Road, Nanjing 210023, China Southwest Hospital/Southwest Eye Hospital, Third Military Medical University (Army Medical University) , Chongqing , People’s Republic of China; Key Lab of Visual Damage and Regeneration & Restoration of Chongqing , Chongqing , People’s Republic of China; Jinfeng Laboratory , Chongqing , China From the Department of Physiology (Y.L., N.E.T., L.L., K.U., A.W.C., N.C.Y., M.L.), Medical College of Wisconsin, Milwaukee, Wis; Department of Physiology and Pathophysiology (L.L.), Fudan University Shanghai Medical College, Shanghai, People’s Republic of China; Department of Pharmacology (N.R.F.), New York Medical College, Valhalla, NY. Hunan Plant Protection Institute Hunan Academy of Agricultural Sciences Changsha 410125 China Southwest Hospital/Southwest Eye Hospital, Third Military Medical University, Chongqing, P.R. China; and Chongqing, P.R. China; Key Lab of Visual Damage and Regeneration and Restoration of Chongqing, Chongqing, P.R. China. Department of Translational Development Celgene Corporation 86 Morris Avenue 07901 Summit NJ USA Hubei Key Laboratory of Cell Homeostasis College of Life Sciences Frontier Science Center for Immunology and Metabolism Institute for Advanced Studies Wuhan University China Department of Otolaryngology-Head Neck Surgery, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan, P.R. China 410008 Institute of Fluorescent Probes for Biological Imaging; University of Jinan; Jinan; P. R. China Analytical Research and Development, Merck & Co. Inc., Rahway, New Jersey07065, United States Department of Oncology Xuzhou Central Hospital Xuzhou Jiangsu 221009 P. R. China Laboratory for Nanomaterials, National Center for Nanoscience and Technology, Beijing, 100190, P. R. China Jiangsu Key Laboratory of Brain Disease Bioinformation, Research Center for Biochemistry and Molecular Biology, Xuzhou Medical College, 84 West Huaihai Road, Jiangsu 221002, China Institute of Neurobiology Xi'an Jiaotong University Basic Medical Sciences Xi'an 710061 China First Department of Acupuncture and Moxibustion, First Affiliated Hospital of Heilongjiang University of CM, Harbin 150040, China. Department of Cardiology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China. Department of Hand Surgery the Fifth Hospital of Harbin Harbin 150040 China Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu 610041, China. Department of Surgery, Medical College, Hunan Normal University, Changsha, China. Department of Physiology Center of Systems Molecular Medicine Medical College of Wisconsin Milwaukee WI USA ComWin Biotech Co., Ltd, Beijing 102206, China. Key Laboratory of Artificial Micro- and Nano-structures of Ministry of Education, School of Physics and Technology, Wuhan University, Wuhan 430072, China Department of Nephrology, The Key Laboratory for the Prevention and Treatment of Chronic Kidney Disease of Chongqing, Kidney Center of PLA, Xinqiao Hospital, Army Medical University (Third Military Medical University), Chongqing 400037, China Foshan (Southern China) Institute for New Materials, Foshan, 528200, Guangdong, P. R. China College of Chemistry and Material Science; Sichuan Normal University; Chengdu; China; Key Laboratory of Treatment for Special Wastewater Treatment Henan Key Laboratory of High-temperature Structural and Functional Materials & National Joint Engineering Research Center for, Abrasion Control and Molding of Metal Materials Henan University of Science and Technology Luoyang 471003 P.R. China Merck & Co., Inc., Rahway, New Jersey 07065, United States Department of Orthopaedics, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing 100730, China. Center of Systems Molecular Medicine, Department of Physiology, Medical College of Wisconsin, Milwaukee, WI, USA Department of Orthopedics the First Affiliated Hospital of Sun Yat‐sen University Guangzhou Guangdong China; Guangdong Provincial Key Laboratory of Orthopedics and Traumatology the First Affiliated Hospital of Sun Yat‐sen University Guangzhou Guangdong China State Key Laboratory of Food Science and Technology; Medical School; Nanchang University; Nanchang; P. R. China Fuwai Yunnan Cardiovascular Hospital, Kunming Medical University, Kunming, Yunnan, China (mainland) Lineberger Comprehensive Cancer Center University of North Carolina School of Medicine Chapel Hill NC USA *Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430030 Wuhan, China; Institute of Plant Protection, Sichuan Academy of Agricultural Sciences, Chengdu 610066, China Center of Systems Molecular Medicine, Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin; Lanzhou University Key Laboratory of Mechanics on Disaster and Environment in Western China attached to the Ministry of Education of China, , Lanzhou, Gansu 730000, People's Republic of China and Department of Mechanics and Engineering Sciences, College of Civil Engineering and Mechanics, , Lanzhou, Gansu 730000, People's Republic of China; Lanzhou University Key Laboratory of Mechanics on Disaster and Environment in Western China attached to the Ministry of Education of China, , Lanzhou, Gansu 730000, People's Republic of China and Department of Mechanics and Engineering Sciences, College of Civil Engineering and Mechanics, , Lanzhou, Gansu 730000, People's Republic of China Department of Respiratory and Critical Care Medicine, Zhoukou Central Hospital, Zhoukou, Henan Province Institute of Neurobiology, Xi’an Jiaotong University Health Science Center Xi’an Shaanxi China Anhui Institute of Optics and Fine Mechanics; Hefei Institutes of Physical Science; Chinese Academy of Sciences; Hefei; PR China Department of Plastic and Burn Surgery, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China State Key Laboratory of Catalysis Dalian Institute of Chemical Physics Chinese Academy of Sciences Dalian National Laboratory for Clean Energy Dalian 116023 P. R. China Institute of Neurobiology, Department of Human Anatomy and Histoembryology, Xi'an Jiaotong University College of Medicine Xi'an, Shaanxi Province, China. Engineering Research Center for Nanophotonics & Advanced Instrument; Ministry of Education; Shanghai Key Laboratory of Magnetic Resonance; Department of Physics; East China Normal University College of Chemistry and Materials Science; Sichuan Normal University; Chengdu; China; Key Laboratory of Special Waste Water Treatment Department of Gastroenterological Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan 610000, China. Key Laboratory of Synthetic and Biological Colloids, Ministry of Education, School of Chemical and Material Engineering, Jiangnan University, Wuxi 214122, China Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China Base of “111 Project” for Biomechanics & Tissue Repair Engineering, Key Laboratory of Biorheological Science and Technology, Ministry of Education, Bioengineering college, Chongqing University, Chongqing, China; Department of Clinical Microbiology, Second Affiliated Hospital of China Medical University, Shenyang, PR China Institute of Atomic and Molecular Physics, Jilin University 1 , Changchun 130012, China and , Changchun 130012, China; Jilin Provincial Key Laboratory of Applied Atomic and Molecular Spectroscopy, Jilin University 1 , Changchun 130012, China and , Changchun 130012, China Department of PediatricsSun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China Laboratory of Biosystems and Microanalysis, State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, 200237, China South China Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences/Key Laboratory of Marine Ranching, Ministry of Agriculture and Rural Affairs/Guangdong Provincial Key Laboratory of Fishery Ecology and Environment, Guangzhou, China; Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), Guangzhou, China; Scientific Observation and Research Field Station of Pearl River Estuary Ecosystem, Guangzhou, China e Department of Experimental Medicine, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, People's Republic of China Chinese Academy of Science Institute of Plasma Physics, , Hefei 230031, China College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Jiangsu 215123, China Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Key Laboratory of Coronary Disease Prevention, Guangdong General Hospital, Guangdong Academy of Medical Sciences, School of Medicine, South China University of Technology, Guangzhou, China Tianjin Center for Disease Control and Prevention, Tianjin 300011, China. Email: harbour5111@aliyun.com. Li Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Research Center, Ningbo University, Ningbo, China Department of Laboratory Medicine, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, China Henan Key Laboratory of Polyoxometalate Chemistry, College of Chemistry and Chemical Engineering, Henan University, Kaifeng, 475004, P. R. China Department of Experimental Medicine, Nanjing Drum Tower HospitalMedical School of Nanjing University 210008 Nanjing Jiangsu China Central Research Lab The Affiliated Drum Tower Hospital of Nanjing University Medical School Nanjing China The First Affiliated Hospital of Soochow University, Jiangsu Institute of Hematology National Clinical Research Center for Hematologic Diseases Suzhou China; Institute of Blood and Marrow Transplantation, Collaborative Innovation Center of Hematology, Soochow University Suzhou China Brainnetome Center, Institute of Automation, Chinese Academy of Sciences, Beijing, China Department of Neurology, Liu’an Affiliated Hospital of Anhui Medical University, Liu’an, China Guangzhou SENVIV Technology Co. Ltd, Guangzhou 510006, P.R.China. Department of Hepatobiliary Surgery, The People's Hospital of Hechuan, Chongqing 401520, P.R. China Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, the Graduate School of the Chinese Academy of Sciences, Shanghai, China Institute of Advanced Materials for Nano‐Bio Applications Wenzhou Medical University Wenzhou Zhejiang 325027 China Kidney Department, Yijishan Hospital of Wannan Medical College, Wuhu 241001, PR China State Key Laboratory of Nuclear Resources and Environment, East China University of Technology, Nanchang 330013, China; School of Water Resources and Environmental Engineering, East China University of Technology, Nanchang 330013, China Department of Developmental Biochemistry, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314 The First Clinical Medical College of Shaanxi University of Traditional Chinese Medicine, Xianyang 712046, China. The Second Department of Internal Medicine‐Oncology Xuzhou Central Hospital Xuzhou Jiangsu 221009 P. R. China Key Laboratory of East China Sea Fishery Resources Exploitation and Utilization, Ministry of Agriculture and Rural Affairs, East China Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Shanghai 200090, China School of Chemistry and Chemical Engineering, Guangdong Pharmaceutical University, Guangzhou510006, P. R. China Chemical Synthesis and Pollution Control Key Laboratory of Sichuan Province, College of Chemistry and Chemical Engineering, China West Normal University, No. 1, Shida Road, Nanchong 637002, China Institute of Neurobiology, Environment and Genes Related to Diseases Key Laboratory of Education Ministry, Xi’an Jiaotong University Health Science Center, School of Basic Medical Sciences, Xi’an 710061, China Department of Hepatobiliary Surgery Changzhou Hospital of Traditional Chinese Medicine Changzhou 213003 Jiangsu Province China School of Chemistry and Chemical Engineering, Tianjin University of Technology, Tianjin, 300384, P. R. China; Tianjin Key Laboratory of Organic Solar Cells and Photochemical Conversion, Tianjin, 300384, P. R. China School of Life and Pharmaceutical Sciences, Dalian University of Technology, Panjin, Liaoning, China Department of Laboratory Medicine, Shengjing Affiliated Hospital, China Medical University, Shenyang, Liaoning 110004, P.R. China Department of Cardiology, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Cardiovascular Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China Nanjing Normal University Chengdu Public Health Clinical Medical Center, Chengdu, Sichuan, China. Department of Medical Oncology, Xuzhou Hospital Affiliated to Medical College of Southeast University and Xuzhou Central Hospital, Xuzhou, China. Department of Dermatology and Sexually Transmitted Diseases, The Third Central Hospital of Tianjin, Tianjin 300170, P.R. China Institute of Cyber-Systems and Control, Zhejiang University, Hangzhou 310027, China; Intelligent Perception and Control Center, Huzhou Institute of Zhejiang University, Huzhou 313098, China Department of Chemistry, University of Colorado—Denver, Denver, Colorado 80217, United States State Key Laboratory of NBC Protection for Civilian, Beijing 102205, P. R. China Department of Immunology Guangzhou Kingmed Diagnostics Group Co., Ltd. Guangzhou China Lab of Nanoscale Biosensing and Bioimaging Institute of Advanced Materials for Nano‐Bio Applications Wenzhou Medical University Zhejiang 325027 China Department of Radiation Oncology,; Lineberger Comprehensive Cancer Center, and; Laboratory of Biological Cancer Therapy, Xuzhou Medical College, Xuzhou 221002, China; Department of Anesthesiology, Qilu Hospital of Shandong University, Shandong, Jinan, People's Republic of China State Key Laboratory of Reproductive Medicine Department of Andrology Nanjing Maternity and Child Health Care Hospital Affiliated to Nanjing Medical University Nanjing China Tianjin Center for Disease Control and Prevention, Tianjin 300011, China. Tunchang County Center for Disease Control & Prevention, Tunchang, Yunnan, PR China. School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing, China; Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin; Department of Chemistry; Beijing Key Laboratory for Microanalytical Methods and Instrumentation; Tsinghua University; Beijing 100084; China Department of Chemistry, School of Science, Beijing Institute of Technology, Beijing 100081, P. R. China; Biomedical Engineerig Academy, School of Ophthalmology and Optometry, Wenzhou Medical College, 270 Xueyuan Road, Wenzhou, Zhejiang 325027, China; School of Energy Engineering, Ulsan National Institute of Science and Technology (UNIST), No. 685 Namyoedong, Junggu, Ulsan, Republic of Korea 681-800; Department of Chemical Engineering, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio 44106 College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, Jiangsu 215123, China Brainnetome Center, Institute of Automation, the Chinese Academy of Sciences, Beijing, China; National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing, China Department of Urology, the Affiliated Hospital of Medical Collage, Qingdao University, Qingdao 266003, China. Email: qyfyliuy@163.com. Merck Research Laboratories, Merck & Co., Inc., 07065, Rahway, NJ, USA Henan Key Laboratory of Polyoxometalate Chemistry, College of Chemistry and Chemical Engineering, Henan University, Kaifeng 475004, China Hunan Institute of Science and Technology, College of Mechanical Engineering, Yueyang 414006, China; Hunan Institute of Science and Technology, Institute of New Energy, Yueyang 414006, China Department of Obstetrics and Gynecology, University of Arkansas for Medical Sciences, Little Rock, Arkansas.; Gene Therapy Program, Department of Internal Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas. School of Advanced Manufacturing, Key Laboratory of Lightweight and High Strength Structural Materials of Jiangxi Province, Nanchang University, Nanchang, Jiangxi 330031, China Department of Experimental Hematology Beijing Institute of Radiation Medicine 27 Taiping Road Beijing 100850 PR China Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Key Laboratory of Coronary Disease, Guangdong General Hospital Guangdong Academy of Medical Sciences Guangzhou Guangdong China; School of Medicine South China University of Technology Guangzhou Guangdong China School of Life Science and Medicine; Dalian University of Technology; Panjin; China Research Center of Analytical Instrumentation, Analytical & Testing Center, Sichuan University, 29 Wangjiang Road, Chengdu 610064, China Dept. of Stomatology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China. Institute of Neurobiology, Xi’an Jiaotong University Health Science Center, Xi’an 710061, China Department of Chemistry Hong Kong Branch of Chinese National Engineering Research Centre for Tissue Restoration and Reconstruction Division of Biomedical Engineering The Hong Kong University of Science and Technology Clear Water Bay Kowloon Hong Kong China Department of Chemistry, Shanghai University, 99 Shangda Road, Shanghai 200444, China Foshan (Southern China) Institute for New Materials Foshan Guangdong 528220 P. R. China State Key Laboratory of Hybrid Rice and Institute of Plant Protection Hunan Academy of Agricultural Sciences Changsha China; Long Ping Branch Graduate School of Hunan University Changsha China Key Laboratory of Artificial Micro/Nano Structure of Ministry of Education, School of Physics and Technology, Wuhan University, Wuhan 430072, China School of Ophthalmology and Optometry School of Biomedical Engineering Wenzhou Medical University 270 Xueyuanxi Road Wenzhou 325027 China Ames Laboratory, U.S. Department of Energy 2 , Ames, Iowa 50011-3020, USA School of Chemistry & Chemical Engineering; State Key Laboratory of Metal Matrix Composites; Shanghai Key Laboratory of Electrical Insulation and Thermal Ageing; Shanghai Jiao Tong University; Shanghai 200240 Zhongshan Hospital of Traditional Chinese Medicine Affiliated to Guangzhou University of TCM, Zhongshan, Guangdong 528400, China Department of Tuberculosis The Public Health Clinical Center of Chengdu Chengdu P.R. China School of Physics and Electronic Information, Yantai University, Yantai 264005, China Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education School of Life Sciences Changchun 130012 China General Manager, Shandong Shuhengtang Biotechnology Co., Ltd, Dezhou, Chian Zhuzhou CRRC Times Electric Co., Ltd., Zhuzhou 412001, China The Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of the Chinese Academy of Sciences, Shanghai, China Center of Systems Molecular Medicine, Department of Physiology, Medical College of Wisconsin, Milwaukee (X.P., X.G., Y.L., M.K.M., P.L., M.L.). Department of Biomedical Sciences, College of Medicine Florida State University Tallahassee Florida USA Analytical & Testing Center; Sichuan University; Chengdu; China Department of Aesthetic Plastic and Burn Surgery, West China Hospital, Sichuan University, Chengdu Sichuan, 610041, P.R.China.liu.yong7088@163.com. Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Institute for Advanced Studies, Wuhan University, Wuhan 430072, China; School of Ophthalmology and Optometry Eye Hospital State Key Laboratory and Key Laboratory of Vision Science Ministry of Health and Zhejiang Provincial Key Laboratory of Ophthalmology and Optometry Wenzhou Medical University Wenzhou China Department of Orthopedics, Tianjin Medical University General Hospital, Tianjin, China (mainland) AECC Beijing Institute of Aeronautical Materials; Beijing; China Institute of High Performance Computing, Agency for Science, Technology and Research (A∗STAR), Singapore State Key Laboratory of Metastable Materials Science & Technology and College of Science; Yanshan University; Qinhuangdao 066004; China Division of Population Health, Centers for Disease Control and Prevention, Atlanta, Georgia Department of Acupuncture and Moxibustion, the First Affiliated Hospital of Heilongjiang University of CM, Harbin 150040, China. The Education Ministry Key Lab of Resource Chemistry and Shanghai Key Laboratory of Rare Earth Functional Materials, Shanghai Normal University, 100 Guilin Road, Shanghai 200234, China Industrial Crop Research Institute, Sichuan Academy of Agricultural Sciences, Chengdu, 610300, China Clinical Laboratory of Shengjing Hospital of Chinese Medical University, Shenyang, China Department of Orthopedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou Guangdong 510515, PR China. lysjyyy@yahoo.com.cn School of Materials Science and Engineering, Harbin Institute of Technology, Harbin 150006, China Merck Research Laboratories, Merck & Co., Inc., Rahway, New Jersey 07065, United States The authors are with the Morehouse School of Medicine, Atlanta, Ga. Sharon K. Davis and Yong Liu are with the Social Epidemiology Research Division, Department of Community Health and Preventive Medicine, and the Cardiovascular Research Institute. Gary H. Gibbons is with the Department of Medicine and the Cardiovascular Research Institute. School of Textiles Science and Engineering, Tiangong University, Tianjin, China Department of Vascular Surgery, The Affiliated Hospital, Southwest Medical University, Luzhou 646000, China College of Plant Protection, Shandong Agricultural University, Taian, China Key Laboratory for Environmental Friendly Chemistry and Application of the Ministry of Education, College of Chemistry, Xiangtan University, Xiangtan, 411105, China, and Department of Chemistry, McGill University, Montreal, QC H3A2K6, Canada College of Life Sciences,Institute for Advanced Studies,Wuhan University,Wuhan,China Department of General Surgery (Vascular Surgery), The Affiliated Hospital of Southwest Medical University, Luzhou 646000, China Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of Coronary Disease, Guangdong General Hospital, Guangdong Academy of Medical Sciences, School of Medicine, South China University of Technology, Guangzhou, China School of Chinese Materia Medica, Beijing University of Chinese Medicine, No. 6 Wang Jing Zhong Huan Nan Lu, Chao Yang District, Beijing 100102, China Department of Internal Medicine, Division of Cardiovascular Health and Disease, University of Cincinnati, Cincinnati, Ohio; School of Chemistry and Chemical Engineering; Tianjin University of Technology; Tianjin; P. R. China Department of General Surgery, Wuhan General Hospital of Guangzhou Military Command, Wuhan 430070, China Department of Radiology; Beijing Children's Hospital; Capital Medical University; Beijing China Longping Branch Graduate School of Hunan University Changsha China; Hunan Plant Protection Institute, Hunan Academy of Agricultural Science Changsha China Department of Rehabilitation, Fengdu People's Hospital Chongqing 408200, China. Department of Chemistry, Laboratory of Advanced Materials, Fudan University, Shanghai 200433, P. R. China State Key Laboratory on Integrated Optoelectronics; Institute of Semiconductors; Chinese Academy of Sciences; Beijing; China Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, and Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China Anhui Key Laboratory of Chemo/Biosensing, College of Chemistry and Materials Science, Anhui Normal University, Wuhu, 241000, P.R. China College of Life Science, Shandong Normal University, Ji'nan 250014, China. biolyqh@yahoo.com.cn Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of Coronary Disease, Guangdong General Hospital, Guangdong Academy of Medical Sciences, School of Medicine, South China University of Technology, Guangzhou, China. Cancer Center of Tongji Hospital, China Department of Neurology The Second Affiliated Hospital of the Third Military Medical University Chongqing China Brainnetome Center, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China; National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China State Key Laboratory of Catalysis Dalian National Laboratory for Clean Energy Dalian Institute of Chemical Physics, Chinese Academy of Sciences Zhongshan Road 457 Dalian 116023 P.R. China Institute of Fluorescent Probes for Biological Imaging; School of Chemistry and Chemical Engineering; School of Materials Science and Engineering; University of Jinan; Jinan Department of Burn and Plastic Surgery, West China Hospital, Sichuan University, Chengdu Sichuan 610041, P R China. Institute of Pediatric Research, Qilu Children's Hospital of Shandong University, Jinan, Shandong 250022, China. liuyi-ly@126.com. From the Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Henan Genuine Biotech Co., Ltd. 10 Fuxing Road, Xincheng District Pingdingshan Henan 467036 China Institute of Neurobiology, National Key Academic Subject of Physiology of Xi’an Jiaotong University, Xi’an 710016, China AECC Beijing Institute of Aeronautical Materials, Beijing 100095, China Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan Hubei, China †Department of Otolaryngology, Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China; Collaborative Innovation Center of Tumor Marker Detection Technology, Equipment and Diagnosis-Therapy Integration in Universities of Shandong, Shandong Province Key Laboratory of Detection Technology for Tumor Makers, School of Chemistry and Chemical Engineering, Linyi University, Linyi 276005, China Laboratory of Biosystems and Microanalysis, State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, China Department of Neurology, Chongqing University Three Gores Hospital, Chongqing 404100, China Center for Drug Discovery, Georgetown University Medical Center, 3970 Reservoir Road, NW, Washington, D.C., 20057, United States; Department of Oncology, Georgetown University Medical Center, 3970 Reservoir Road, NW, Washington, D.C., 20057, United States School of Artificial Intelligence Beijing University of Posts and Telecommunications Beijing China Department of Process Research, Merck Research Laboratories, P.O. Box 2000 Rahway, New Jersey 07065 Anhui Institute of Optics and Fine Mechanics Chinese Academy of Sciences Hefei 230031 China Department of Laboratory Medicine Nanjing Drum Tower Hospital Nanjing University Medical School Nanjing China Lab of Biosystems and Microanalysis, State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, China Department of Orthopaedics, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China Department of Laboratory Medicine, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, Jiangsu 210008, China. South China Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Guangzhou, Guangdong, People's Republic of China College of Life Sciences and Food Engineering, Hebei University of Engineering Handan China Beijing Engineering Research Center for BioNanotechnology & Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety CAS Center for Excellence in Nanoscience National Center for NanoScience and Technology No. 11 Zhongguancun Beiyitiao Beijing 100190 China; University of Chinese Academy of Sciences Beijing 100049 China School of Chemistry and Chemistry Engineering and School of Resource, Environmental and Safety Engineering, University of South China, 28 Chang’sheng Road, Hengyang 421001, P. R. China Laboratory for Stem Cell and Regenerative Medicine, Affiliated Hospital of Weifang Medical University, Weifang, China Hunan Institute of Optoelectronic Integration College of Materials Science and Engineering Hunan University Changsha 410082 P. R. China State Key Laboratory of Modern Optical Instrumentation, Zhejiang University, Hangzhou 310027, China State Key Laboratory of Powder Metallurgy; Central South University; Changsha Hunan 410083 People's Republic of China Department of Neurology, Xinqiao Hospital, Third Military Medical University, Chongqing, China. Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Department of Chemistry and Advanced Materials Laboratory, Fudan University, Shanghai 20043, People’s Republic of China Department of Ophthalmology, Southwest Hospital, Southwest Eye Hospital, Army Medical University, Chongqing, China;; Key Lab of Visual Damage and Regeneration & Restoration of Chongqing, Chongqing, China; Department of Orthopaedic Surgery, Affiliated Hospital of Medical College, Qingdao University, Qingdao, Shandong 266003, China. liuyong@medmail.com.cn School of Physics and Technology and The Key Laboratory of Artificial Micro- and Nano-Structures of Ministry of Education, Wuhan University, Wuhan 430072, China Department of Neurosurgery, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, Jiangsu; Southwest Hospital/Southwest Eye Hospital Army Medical University Chongqing China; Key Lab of Visual Damage and Regeneration & Restoration of Chongqing Chongqing China These authors contributed equally to this work.; Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China Department of Oncology, Chongqing Hospital of Traditional Chinese Medicine, Chongqing, China School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China Department of Ophthalmology, Air Force Medical Center, PLA, Beijing, PR China College of Pharmacy, Hubei University of Chinese Medicine Wuhan 430065, China. Department of Orthopaedic Surgery, Peking Union Medical College and Chinese Academy of Medical Sciences, Peking Union Medical College Hospital, Beijing, China. State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Functional Polymer Materials, Ministry of Education, Institute of Polymer Chemistry, Collaborative Innovation Center of Chemical Science and Engineering, Nankai University, Tianjin 300071, China Institute of Plant Protection, Hunan Academy of Agricultural Sciences, Changsha 410125, China; Yuelushan Laboratory, Changsha 410215, China Chengdu University of Traditional Chinese Medicine, Chengdu; Department of Cardiology, Zigong Third People's Hospital, Zigong, Sichuan, China. Southwest Hospital/Southwest Eye Hospital, Third Military Medical University, (Army Medical University), Chongqing 400038, China Faculty of Psychology, Southwest University, Chongqing 400715, China; Key Laboratory of Cognition and Personality (Ministry of Education), Southwest University, Chongqing 400715, China Department of Pathology, Third Affiliated Hospital Sun Yat‐Sen University (SYSU) Guangzhou Guangdong P.R. China Key Laboratory for Large-Format Battery Materials and System (Ministry of Education), School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Luoyu Road 1037, Wuhan 430074, P. R. China Department of Burn and Plastic Surgery, West China Hospital, Sichuan University, Chengdu, China. Department of Renal Transplantation and Urology Shanghai First People's Hospital Shanghai Jiaotong University China Key Laboratory of Artificial Micro- and Nano-structures of Ministry of Education, School of Physics and Technology, Wuhan University, Wuhan 430072, People's Republic of China Key Laboratory for Agro-Ecological Processes in Subtropical Region, Hunan Research Center of Livestock and Poultry Sciences, South Central Experimental Station of Animal Nutrition and Feed Science in the Ministry of Agriculture, Institute of Subtropical Agriculture, The Chinese Academy of Sciences, Changsha, Hunan 410125, China Ames Laboratory, Ames, IA 50011, USA. Pediatric Department, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China. William R. Wiley Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, P.O. Box 999, MSIN K8-88, Richland, Washington 99352 Systems Biology and Medicine Center for Complex Diseases, Affiliated Hospital of Qingdao University, Qingdao, China; School of Medicine and Pharmacy, Ocean University of China, Qingdao, China. Collaborative Innovation Center of Tumor Marker Detection Technology Equipment and Diagnosis-Therapy Integration in Universities of Shandong Shandong Province Key Laboratory of Detection Technology for Tumor Makers School of Chemistry and Chemical Engineering Linyi University Linyi 276005 P. R. China State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, and Laboratory of Advanced Materials, Fudan University, Shanghai 200433, People’s Republic of China Department of Vascular Surgery The Affiliated Hospital of Southwest Medical University Luzhou China Department of Chemistry, Laboratory of Advanced Materials, State Key Laboratory of Molecular Engineering of Polymers, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Collaborative Innovation Center of Chemistry for Energy Materials (iChEM), Fudan University, Shanghai 200433, PR China Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, China Ministry of Agriculture Key Laboratory of Mariculture Ecology and Products Quality and Safety, South China Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, 231th Xingang West Road, Guangzhou 510300, China National Clinical Research Center for Geriatric Disorders (Xiangya Hospital) Changsha 410008, Hunan, The People's Republic of China. Engineering Research Center of Biopolymer Functional Materials of Yunnan, Key Laboratory of Comprehensive Utilization of Mineral Resources in Ethnic Districts School of Chemistry and Biotechnology, Yunnan Minzu University Kunming Yunnan 650500 People's Republic of China Key Laboratory of Nuclear Solid State Physics Hubei Province, School of Physics and Technology, Wuhan University, Wuhan 430072, China Hunan Academy of Agricultural Sciences Hunan Plant Protection Institute Changsha 410125 China State Key Laboratory of Powder Metallurgy, Central South University, Changsha 410083, China; Powder Metallurgy Research Institute, Central South University, Changsha 410083, China Department of Analytical Sciences, MRL Merck & Co., Inc. 126 East Lincoln Ave Rahway NJ 07065 USA Department of Radiation Oncology and Lineberger Comprehensive Cancer Center; School of Medicine; University of North Carolina at Chapel Hill; Chapel Hill, NC, USA; Jiangsu Center for the Collaboration and Innovation of Cancer Biotherapy; Cancer Institute; Xuzhou Medical College; Xuzhou, Jiangsu, China Key Lab of Environmental Optics and Technology, Anhui Institute of Optics and Fine Mechanics, Chinese Academy of Sciences, Hefei 230031, China. Department of Orthopedics, The People's Hospital of Suzhou New District, Suzhou, Jiangsu Department of Nursing, Chongqing Medical and Pharmaceutical College Chongqing China Clinical Laboratory, The Third Hospital of Nanchang City Nanchang 330009, Jiangxi, People's Republic of China. School of Materials Science and Engineering Henan University of Science and Technology Luoyang 471023 P. R. China State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Functional Polymer Materials of Ministry of Education, Institute of Polymer Chemistry, College of Chemistry, Nankai University, Tianjin 300071, China AVIC Beijing Institute of Aeronautical Materials; Beijing 100095; P. R. China School of Environmental & Biological Engineering, Wuhan Technology and Business University, Wuhan City, Hubei province 430065, P. R. China Department of Vascular Surgery, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China Jiangsu Key Laboratory for Chemistry of Low-Dimensional Materials, School of Chemistry and Chemical Engineering, Huaiyin Normal University, Huaian 223300, P. R. China Institute of Toxicology, College of Preventive Medicine, Third Military Medical University, Chongqing, P. R. China Yunnan Academy of Tobacco Agricultural Sciences Key Laboratory of Tobacco Biotechnological Breeding National Tobacco Genetic Engineering Research Center Kunming China The authors are affiliated with the Epidemiology Support Branch, Division of Population Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, 4770 Buford Highway, N.E., Mailstop K-67, Atlanta, GA 30341 (e-mail: ). A previous ver-sion of this report was presented in part at the Institute on Psychiatric Ser-vices, San Francisco, October 27–30, 2011. Department of Cardiology, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital Guangdong Academy of Medical Sciences Guangzhou 510080 China Department of Cardiology Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Southern Medical University Guangzhou China; Department of Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences Guangzhou China; The Second School of Clinical Medicine Southern Medical University Guangzhou China; Guangdong Provincial People's Hospital, School of Medicine South China University of Technology Guangzhou China Institute of Neurobiology, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, China. Geneseeq Research Institute, Nanjing Geneseeq Technology Inc. Nanjing China Brainnetome Center, Institute of Automation, Chinese Academy of Sciences; Beijing 100190 China; National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences; Beijing 100190 China Department of Animal Science College of Life Sciences and Food Engineering Hebei University of Engineering Handan China Department of Surgery, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China. William R. Wiley Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, P.O. Box 999, MSIN K8-88, Richland, Washington 99352, Department of Mechanical Engineering, University of Delaware, Newark, Delaware 19716, and Department of Aerospace and Mechanical Engineering, University of Southern California, Los Angeles, California 90089 College of Pharmacy, Dali University, Dali 671003, China Key Laboratory of Artificial Micro‐ and Nano‐Structures of Ministry of Education School of Physics and Technology Wuhan University Wuhan 430072 China Henan Key Laboratory of Polyoxometalate Chemistry; College of Chemistry and Chemical Engineering; Henan University; Kaifeng; China Department of Orthopaedic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College , Beijing , China Department of Plastic Surgery, West China Hospital, Sichuan University, Chengdu Sichuan, 610041, P.R.China. |
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