http://rdf.ncbi.nlm.nih.gov/pubchem/author/MD5_789ec94d4c92062d7648a8ff68f5d5e2
Outgoing Links
Predicate | Object |
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family-name | Hui Chen Chen |
name | Hui Chen |
given-name | Hui |
organization-name | Renal Medicine, Kolling Institute, Royal North Shore Hospital, University of Sydney, Sydney, New South Wales, Australia; School of Life Sciences, Faculty of Science, University of Technology Sydney, Sydney, New South Wales, Australia Oncology Beijing Institute of Dental Research, Beijing Stomatological Hospital and School of Stomatology, Capital Medical University, Beijing, China School of medicine Jiangsu University Zhenjiang China Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China Wadsworth Center New York State Department of Health Albany New York 12208 Faculty of Psychology Beijing Normal University China NCCAMNIHBethesdaMarylandUSA Ministry of Education Key Laboratory for Analytical Science of Food Safety and Biology; Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety; College of Chemistry; Fuzhou University; Fuzhou State Key Laboratory of Inorganic Synthesis and Preparative Chemistry; International Joint Research Laboratory of Nano-Micro Architecture Chemistry; College of Chemistry; Jilin University; Changchun 130012 Department of Oral Health Sciences, The University of British Columbia, Vancouver, BC, Canda Department of Pathology Jinling Hospital Affiliated Hospital of Medical School Nanjing University Nanjing Jiangsu China Shanghai Key Laboratory of Atmospheric Particle Pollution and Prevention (LAP3), Department of Environmental Science & Engineering, Institute of Atmospheric Sciences, Fudan University, Shanghai 200438, China Shanghai Key Laboratory of Atmospheric Particle Pollution and Prevention (LAP3), Department of Environmental Science and Engineering, Fudan University, Shanghai 200433, China; Shanghai Institute of Pollution Control and Ecological Security, Shanghai 200092, China 1Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205 State Key Laboratory of Microbial Metabolism and College of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Minhang District, Shanghai 200240, China Manitoba Centre for Health Policy, Winnipeg, Canada Department of Pathology The Third Affiliated Hospital, Guangzhou Medical University Guangzhou P.R. China Key Laboratory of Artificial Micro- and Nano-structures of Ministry of Education; School of Physics and Technology; Wuhan University; Wuhan 430072; China Department of Agronomy, Kansas State University, Manhattan, KS, USA. State Key Laboratory of Marine Food Processing & Safety Control, College of Food Science and Engineering, Ocean University of China, No. 1299 Sansha Road, Qingdao, P. R. China Department of Radiation Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China Third Division, Department of Cardiology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei 050011, PR China School of Public Health, Zhejiang University School of Medicine Hangzhou China College of Pharmacy, Guilin Medical University, Guilin 541199, People’s Republic of China. The Institute of Chemistry and the Lise Meitner-Minerva Center for Computational Quantum Chemistry, The Hebrew University of Jerusalem, 91904 Jerusalem, Israel Peng Cheng Laboratory I. M. Sechenov First Moscow State Medical University, Moscow, Russian Federation School of Pharmacy, Southwest Medical University, Luzhou 646000, China State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, People’s Republic of China. Department of Cardiology The Second Hospital of Hebei Medical University Shijiazhuang Hebei People's Republic of China College of Forestry Northwest A and F University Yangling Shaanxi China; State Key Laboratory for Conservation and Utilization of Subtropical Agro‐Bioresources College of Forestry and Landscape Architecture, South China Agricultural University Guangzhou Guangdong China Surrozen Inc Department of Radiology Medical Community of Linhai First People's Hospital 375 Dayang West Road Linhai Zhejiang 317000 China; Department of Radiology Fudan University Shanghai Cancer Center 270 Dongan Road Shanghai 200032 China; Department of Oncology Shanghai Medical College Fudan University Shanghai 200032 China Department of Plastic Surgery, Tangdu Hospital, Fourth Military Medical University, Xi’an, China School of Life Sciences, Faculty of Science, University of Technology Sydney, Sydney, NSW 2007, Australia Key Laboratory for Green Processing of Chemical Engineering of Xinjiang Bingtuan School of Chemistry and Chemical Engineering Shihezi University Shihezi 832003 P. R. China College of Life Sciences, Sichuan Agricultural University, Yaan, China School of Chemical and Biomedical Engineering, Nanyang Technological University, 62 Nanyang Drive, Singapore 637459 Department of Nephrology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, P.R. China College of Life Science, Sichuan Agricultural University, Ya’an, China College of Materials and Chemical Engineering Key laboratory of inorganic nonmetallic crystalline and energy conversion materials China Three Gorges University Yichang 443002 P. R. China Collaborative Innovation Center for Respiratory Disease Diagnosis, Treatment & Chinese Medicine Development of Henan Province, Henan University of Chinese Medicine, Zhengzhou, China; School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, China Microbiology Department, Jiangxi Provincial People's Hospital Affiliated to Nanchang University, Nanchang, China. School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu 610032, China Centre for Health Technologies and School of Life Sciences, University of Technology Sydney, Sydney, New South Wales, Australia; Faculty of Basic Medical Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China; and Department of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, China State Key Laboratory of Inorganic Synthesis and Preparative Chemistry; College of Chemistry; Jilin University; Changchun 130012; P. R. China Department of Thoracic Surgery, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China College of Food Science and Technology, Nanjing Agricultural University, Nanjing, Jiangsu 210095, People's Republic of China Yibin University Hospital, Yibin, Sichuan 644000, China; Key Lab of Process Analysis and Control of Sichuan Universities, Yibin University, Yibin, Sichuan 644000, China Technology Innovation Center for Exploitation of Marine Biological Resources, Third Institute of Oceanography, Ministry of Natural Resources, Xiamen City, China. Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases; School of Pharmaceutical Sciences; Tsinghua University; Beijing; China Department of Plastic and Reconstructive Surgery, Laser Center, Shanghai Ninth People's Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, China. School of Materials and Energy, National Center for International Research on Photoelectric and Energy Materials, Yunnan University, Kunming, P. R. China Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, P. R. China, and Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Perking Union Medical College, Beijing 100050, P. R. China Centre for Polymer from Renewable Resources, School of Food Science and Engineering, South China University of Technology, Guangzhou, China Beijing National Laboratory for Molecular Sciences (BNLMS), CAS Key Laboratory of Photochemistry, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, China; Institute of Chemistry and the Lise Meitner-Minerva Center for Computational Quantum Chemistry, The Hebrew University of Jerusalem, Givat Ram Campus, 91904 Jerusalem, Israel School of Science and Engineering, The Chinese University of Hong Kong, Shenzhen, China.; Shenzhen Institute of Artificial Intelligence and Robotics for Society, Shenzhen, China. Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China Department of Cardiology, Renmin Hospital of Wuhan University, Cardiovascular Research Institute of Wuhan University, Wuhan, Hubei, China Department of Anesthesiology and Perioperative Medicine, Translational Research Institute of Brain and Brain-Like Intelligence, Shanghai Fourth People’s Hospital Affiliated to Tongji University School of Medicine, Shanghai 200434, China Department of Surgery, Children's Hospital Los Angeles, Keck School of Medicine University of Southern California Los Angeles CA USA; Division of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine University of Cincinnati College of Medicine Cincinnati OH USA College of Forestry Northwest A&F University Yangling China Department of Dermatology, Tongji Hospital of Tongji Medical College Huazhong University of Science and Technology Hankou, Wuhan People's Republic of China Fudan University College of Chemistry and Chemical Engineering, State Key Laboratory of Physical Chemistry of Solid Surfaces Collaborative Innovation Center of Chemistry for Energy Materials Xiamen University Xiamen 361005 P. R. China Department of Anesthesiology Changhai Hospital Shanghai 200433 China Department of Pharmacy, Beijing Chao-yang Hospital, Capital Medical University, Beijing, China. 2School of Life SciencesFaculty of Science, University of Technology Sydney, Sydney, New South Wales, Australia Department of Epidemiology and Biostatistics Shandong University Jinan Shandong China Provincial Clinical College of Fujian Medical University, Fujian Provincial Cardiovascular Disease Institute, Fuzhou 350001, China. chen.hui@medmail.com.cn a School of Pharmaceutical Science, Henan University of Traditional Chinese Medicine , Zhengzhou, 450008, China Key Laboratory of Design and Assembly of Functional Nanostructures, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Fuzhou, Fujian 350002, P. R. China Institute of Chemistry and the Lise Meitner-Minerva Center for Computational Quantum Chemistry, Hebrew University of Jerusalem, Givat Ram Campus, 91904 Jerusalem, Israel; Beijing National Laboratory for Molecular Sciences (BNLMS), CAS Key Laboratory of Photochemistry, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, China Key Laboratory of Organic Solids, Beijing National Laboratory for Molecular Sciences (BNLMS), Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, People’s Republic of China Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences, School of Life Sciences, East China Normal UniversityShanghai, 200241, China. Department of Epidemiology and Health Statistics,Chengdu 610041,China. Department of Student Affairs,West China School of Public Health and West China Fourth Hospital,Sichuan University,Chengdu 610041,China. Department of Epidemiology and Health Statistics,School of Public Health,CAMS and PUMC,Beijing 100730,China. Department of Food Science and Engineering; National Engineering Research Center of Seafood; Dalian Polytechnic University; Dalian; China Department of Cardiology, Beijing Friendship Hospital, Capital Medical University, Beijing Key Laboratory of Metabolic Disorder-Related Cardiovascular Disease, Beijing, China (mainland) Institute of Biomedical Engineering, Capital Medical University, Beijing 100069, China. Cardiovascular Center, Affiliated Friendship Hospital, Capital Medical University Beijing, 100050, P. R. China Department of Oral & Maxillofacial Surgery College of stomatology, North China University of Science and Technology Tangshan City Hebei Province China Division of Oral Pathology, Beijing Institute of Dental Research, Beijing Stomatological Hospital and School of Stomatology, Capital Medical University, Dongcheng District, Beijing, China Department of Physiology, School of Basic Medical Science, Central South University, Changsha, China Hunan Key Laboratory of Green Chemistry and Application of Biological Nanotechnology, Hunan University of Technology, Zhuzhou 412007, PR China Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital School of Medicine Institute of Infectious Diseases Hubei Center for Disease Control and Prevention Wuhan China Department of Nephrology Shanghai East Hospital School of Medicine, Tongji University Shanghai China State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, Peopleʼs Republic of China Guangdong Key Laboratory of Liver Disease Research The Third Affiliated Hospital of Sun Yat‐sen University Guangzhou China School of Materials Science and Engineering, Shanghai University, Shanghai 200072, China Department of Chemical and Materials Engineering, National Central University, Jhongli, Taoyuan, Taiwan. Department of Orthopaedics, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, China Beijing National Laboratory for Molecular Sciences; CAS Key Laboratory of Photochemistry; Institute of Chemistry; Chinese Academy of Sciences; Beijing Department of Orthopaedics, Zhongda Hospital, Southeast University, Nanjing 210009, Jiangsu Province, P.R.China MOE Laboratory of Biosystem Homeostasis and Protection College of Life Sciences Zhejiang University Hangzhou Zhejiang 310058 China Shenzhen Grubbs Institute and Department of Chemistry, Southern University of Science and Technology, Shenzhen 518055, China; Academy for Advanced Interdisciplinary Studies, Department of Chemistry, Southern University of Science and Technology, Shenzhen 518055, China Developmental Biology and Regenerative Medicine Program, The Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, California; SUGEN, Inc., 230 E. Grand Avenue, South San Francisco, California 94080 Department of Orthopedics, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, China; Multidisciplinary Team (MDT) for Geriatric Hip Fracture Management, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, China; School of Medicine, Southeast University, Nanjing, China; Orthopaedic Trauma Institute (OTI), Southeast University, Nanjing, China; Trauma Center, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, China State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, The Chinese Academy of Sciences, Fuzhou, Fujian 350002, China School of Food Science and Technology; National Engineering Research Center of Seafood; Dalian Polytechnic University; Dalian 116034; China Department of Gastroenterology, People's Hospital of Taizhou, 210 Yingchun Road, Taizhou, Jiangsu, China chenhuiscience@outlook.com. Developmental Biology and Regenerative Medicine Program, Childrens Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, CA 90027, USA Department of Basic Research, Yantai Vocational College, Yantai, China. State and Local Joint Engineering Laboratory for Novel Functional Polymeric Materials, Suzhou Key Laboratory of Macromolecular Design and Precision Synthesis, Department of Polymer Science and Engineering, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, P. R. China Eye InstituteAffiliated Hospital of Nantong University Nantong China Ministry of Education Key Laboratory for Analytical Science of Food Safety and Biology, Fujian Province Key Laboratory of Analysis and Detection Technology for Food Safety, College of Chemistry, Fuzhou University, Fuzhou, Fujian, 350116, China Collaborative Innovation Center for Respiratory Disease Diagnosis and Treatment & Chinese Medicine Development of Henan Province, Henan University of Chinese Medicine, Zhengzhou, P.R. China; School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, P.R. China Key Laboratory of Artificial Micro/Nano-Structures, Ministry of Education School of Physics and Technology, Wuhan University, Wuhan 430072, China College of Forestry Northwest A & F University Yangling Shaanxi P. R. China Fujian Provincial Cardiovascular Disease Institute, Fujian Medical University, Fuzhou, Fujian, China College of Science and Technology, Ningbo University, Cixi 315302, China Department of Pediatrics the First Affiliated Hospital of Nanjing Medical University Nanjing China Department of Ophthalmology, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China Chengdu 610072, China. Department of Anesthesiology and Perioperative Medicine, Shanghai Fourth People’s Hospital, School of Medicine, Tongji University Hypertension-Endocrine Branch, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892 Department of Oncology, Changshu No. 1 People’s Hospital, Changshu, PR China Guangxi Key Laboratory of AIDS Prevention and Treatment & Guangxi Universities Key Laboratory of Prevention and Control of Highly Prevalent Disease, School of Public Health, Guangxi Medical University, Nanning, People’s Republic of China Department of Pathology, First Affiliated Hospital, Changsha 410005, China Department of Ophthalmology, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, School of Medicine University of Electronic Science and Technology of China Chengdu China Department of Critical Care Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, P.R. China Key Laboratory of Photochemistry Institute of Chemistry Chinese Academy of Sciences Beijing 100190 China Soochow University Department of Pharmacology, Laboratory of Molecular Neuropathology, Jiangsu Key Laboratory of Neuropsychiatric Diseases and College of Pharmaceutical Sciences, , Suzhou, Jiangsu 215123 , China Department of Pharmacology, ‡Department of Molecular and Human Genetics and Huffington Center on Aging, §Integrative Molecular and Biomedical Sciences Graduate Program, ∥USDA/ARS Children Nutrition Research Center and Department of Pediatrics, ⊥Center for Drug Discovery, Dan L. Duncan Cancer Center, and Cardiovascular Research Institute, Baylor College of Medicine, Houston, Texas 77030, United States Chongqing University Cancer Hospital, Chongqing, China College of Electrical Engineering and Automation Shandong University of Science and Technology Qingdao China State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Biology Hunan University Changsha Hunan China College of Life Science, Sichuan Agricultural University, Xinkang Road 46, Ya’an, Sichuan 625014, China Department of Endodontics, Jinan Stomatological Hospital, Jinan, Shandong Province, China Gansu University of Traditional Chinese Medicine, Lanzhou, PR China Key Laboratory of RNA Biology, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100084, China Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA Department of Organic Chemistry and the Lise Meitner-Minerva Center for Computational Quantum Chemistry, The Hebrew University of Jerusalem, Givat Ram Campus, 91904 Jerusalem, Israel, and Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, Katahira, Sendai 980-8577, Japan College of Life Sciences, Capital Normal University, Beijing 100048, China (X.Q.W., W.Z.L., Y.H., T.Y.K., Y.K.H.); Institute of Botany, Chinese Academy of Sciences, Beijing 100093, China (X.Q.W., H.C., T.Y.K., S.H.S.); Department of Energy Plant Research Laboratory, Michigan State University, East Lansing, Michigan 48824(P.F.Y.); Department of Plant Sciences, University of Cambridge, Cambridge CB Clinical Laboratories, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, People's Republic of China. Department of Ophthalmology, Nanjing Drum Tower Hospital, Affiliated to Nanjing University Medical School State Key Laboratory of Conservation and Utilization of Subtropical Agro-Bioresources , Guangdong Laboratory for Lingnan Modern Agriculture, Guangdong Key Laboratory for Innovative Development and Utilization of Forest Plant Germplasm, College of Forestry and Landscape Architecture, South China Agricultural University, Guangzhou 510642 , P.R. China Department of Orthopaedics, Jinshan Hospital, Fudan University, Shanghai, China Department of Plastic and Reconstructive Surgery Shanghai Ninth People's Hospital, Shanghai Jiao Tong University, School of Medicine Shanghai China Shanghai Jiao Tong University, State Key Laboratory of Advanced Optical Communication Systems and Ne State Key Laboratory of Crop Genetics and Germplasm Enhancement, Nanjing Agricultural University, Nanjing 210095, China From the Department of Ophthalmology, Affiliated Hospital of Nantong University, Nantong, China; Basic Medical Laboratory Institute of Clinical Laboratory Science Jinling Hospital Clinical School of Medical College Nanjing University Nanjing China Cardiovascular Center Beijing Friendship Hospital Capital Medical University Beijing China Department of Chemistry; University of Utah; Salt Lake City; USA School of Pharmacy, Guilin Medical University, Guilin, China; Ophthalmology Department School of Material Science and Engineering, Shanghai University, Shanghai 200072, China. Department of Ultrasound The Fifth Affiliated Hospital of Sun Yat‐sen University Zhuhai China CAS Key Laboratory of Photochemistry; Institute of Chemistry; Chinese Academy of Sciences; Beijing 100190; China Department of Radiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, Shanghai 200241, P. R. China Center for Reproductive Genetics and Reproductive Medicine, Sun Yat-sen Memorial Hospital, Sun Yat-sen University , Guangzhou 510120 , China Department of Rehabilitation Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong 510280, China; School of Rehabilitation Medicine, Southern Medical University, Guangzhou, Guangdong 510515, China State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People’s Republic of China Department of Pathology The Third Affiliated Hospital of Guangzhou Medical University Guangzhou China Central Laboratory, Chaozhou Central Hospital, Chaozhou 521021, P.R. China. School of Life Sciences, Faculty of Science, University of Technology Sydney Department of Thoracic Surgery Shanghai Public Health Clinical Center Shanghai China Department of Chemistry, Capital Normal University, Beijing 100037, China. chenh16@sohu.com Central Laboratory Guizhou Provincial People's Hospital Guiyang Guizhou China Internal Medical Department, Medical Health Center, Beijing Friendship Hospital, Capital Medical University, Beijing, China Department of Chemistry and Institutes of Biomedical Sciences, Fudan University, Shanghai 200433, P.R. China Department of Fibre and Polymer Technology Wallenberg Wood Science Center KTH Royal Institute of Technology Teknikringen 56 Stockholm 100 44 Sweden Department of Surgery, The Second Affiliated Hospital of Wenzhou Medical College, No. 109, West Xue-yuan Road, Wenzhou 325027, PR China. State Key Laboratory for Conservation and Utilization of Subtropical Agro‐bioresources (South China Agricultural University), Guangdong Key Laboratory for Innovative Development and Utilization of Forest Plant Germplasm College of Forestry and Landscape Architecture, South China Agricultural University Guangzhou China Department of Cardiology, Cardiovascular Center, Beijing Friendship Hospital, Capital Medical University, 95 Yongan Road, Beijing 100050, China Emergency Department, The Second Hospital, Hebei Medical University, Shijiazhuang, Hebei 050000, P.R. China School of Chemical Engineering, Sichuan University, Chengdu 610065, P. R. China Programs in Developmental Biology, Neuroscience, and Human Genetics, Department of Biopharmaceutical Sciences, University of California, San Francisco, CA 94143-2811; Contribution from the Lab of Mesoscopic Chemistry, Institute of Theoretical and Computational Chemistry, Department of Chemistry, Nanjing University, Nanjing 210093, People's Republic of China Key Laboratory of Acupuncture and Medicine Research of Ministry of Education, Nanjing University of Chinese Medicine, Nanjing 210023, China Department of Ultrasound, The Third Affiliated Hospital of Soochow University 185 Juqian Street, Changzhou 213003, Jiangsu Province, China. Department of Psychology, School of Humanities and Social Sciences, Beijing Forestry University, Beijing, P.R. China. Guangdong Province Key Laboratory for Biotechnology Drug Candidate, School of Life Science and Biopharmaceutics Guangdong Pharmaceutical University China Key Laboratory of Bio-based Polymeric Materials Technology and Application of Zhejiang Province, Ningbo Institute of Materials Technology & Engineering, Chinese Academy of Sciences, 1219 Zhongguan West Road, Ningbo 315201, Zhejiang, People’s Republic of China; University of the Chinese Academy of Sciences, 19A Yuquan Road, Beijing 100049, Beijing, People’s Republic of China Research Center, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen 518107, Guangdong Province, China. Key Laboratory of Mesoscopic Chemistry of Ministry of Education, Institute of Theoretical and Computational Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, P. R. China Beijing National Laboratory for Molecular Sciences (BNLMS), Key Laboratory of Photochemistry, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China Beijing Key Laboratory of Microanalytical Methods and Instrumentation, Department of Chemistry, Tsinghua University, Beijing 100084, China Shenzhen Grubbs Institute and Department of Chemistry, Southern University of Science and Technology, Shenzhen 518055, P. R. China Institute of Physics, Chinese Academy of Sciences, Beijing 100190, China Department of Respiratory, Emergency and Critical Care Medicine, First Affiliated Hospital of Soochow University, Jiangsu Department of Cardiology, Pu Ai Hospital of Wuhan City, Wuhan 430034, China. ; Department of Cardiology, Zhongnan Hospital of Wuhan University, Wuhan 430071, China. ENT Institute and Otorhinolaryngology Department, Affiliated Eye and ENT Hospital, Fudan University, Shanghai, China Department of Pathology Nanfang Hospital Southern Medical University Guangzhou Guangdong China; Department of Pathology School of Basic Medical Sciences Southern Medical University Guangzhou Guangdong China Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, Sendai 980-8577, Japan, RIKEN SPring-8 Center, Harima Institute, Sayo, Hyogo 679-5148, Japan, and Department of Organic Chemistry and the Lise Meitner-Minerva Center for Computational Quantum Chemistry, The Hebrew University of Jerusalem, Givat Ram Campus, 91904 Jerusalem, Israel Key Laboratory of Xin’an Medicine, Ministry of Education Chinese‐American Research Institute for Diabetic Complications Department of Pharmacy Wenzhou Medical University Wenzhou China School of Food Science and Technology, National Engineering Research Center of Seafood, Dalian Polytechnic University, Dalian 116034, China CAS Key Laboratory of Photochemistry Institute of Chemistry Chinese Academy of Sciences Beijing 100190 P. R. China; University of Chinese Academy of Sciences Beijing 100049 P. R. China State Key Laboratory of Electronic Thin Film and Integrated Devices, University of Electronic Science and Technology of China, Chengdu 610054, China State Key Laboratory for Agro‐Biotechnology China Agricultural University Beijing 100193 China; Ministry of Agriculture and Rural Affairs, Key Laboratory for Pest Monitoring and Green Management, Department of Plant Pathology China Agricultural University Beijing 100193 China Department of Chemistry Capital Normal University Beijing 100048 China China Rehabilitation Research Center, Beijing, China; Institute of Rehabilitation Science of China, Beijing, China; Center of Neural Injury and Repair, Beijing Institute for Brain Disorders, Beijing, China; Beijing Key Laboratory of Neural Injury and Rehabilitation, Beijing, China Department of Stomatology, North China University of Science and Technology Affiliated Hospital, Tangshan, 063000 Hebei, China §Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical School, Philadelphia, PA 19104; and School of Public Health, Zhejiang University School of Medicine , Hangzhou , China From the Diabetes Unit, National Center for Complementary and Alternative Medicine (NCCAM), National Institutes of Health, Bethesda, Maryland Donald Danforth Plant Science Center St. Louis MO 63132 USA; Conagen Inc. Bedford MA 01730 USA Department of Otolaryngology-Head and Neck Surgery, Shanghai Key Clinical Disciplines of Otolaryngology, Eye and ENT Hospital of Fudan University, 83 Fenyang Road, Xuhui District, Shanghai 200031, People’s Republic of China Trillium Therapeutics, Mississauga, ON, Canada Institute for Physical Chemistry and Center for Soft Nanoscience (SoN), University of Münster, Corrensstraße 28-30, 48149 Münster, Germany Department of Radiography, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, China Shengli Clinical Medical College of Fujian Medical University, Fuzhou, FJ, China; Hypertension Laboratory, Fujian Provincial Cardiovascular Disease Institute, Fuzhou, FJ, China Authors' Affiliations: 1Department of Hepato-Biliary-Pancreatic Surgery, First Affiliated Hospital, Zhejiang University School of Medicine; 2Department of Oncological Surgery, Zhejiang Cancer Hospital, Hangzhou; and 3Department of Hepato-Biliary-Pancreatic Surgery, Second Affiliated Hospital of Wenzhou Medical College, Wenzhou, Zhejiang, China Beijing National Center for Condensed Matter Physics and Institute of Physics, Chinese Academy of Sciences, Beijing 100190, PR China; School of Physical Sciences, University of Chinese Academy of Sciences, Beijing 100190, PR China Key Laboratory of Design and Assembly of Functional Nanostructures, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Fuzhou, Fujian 350002, People’s Republic of China Jiangsu Province Blood Center, Nanjing 210042, Jiangsu Province, China. Ningxia Provincial Center for Disease Control and Prevention, Yinchuan, People's Republic of China State Key Laboratory of Inorganic Synthesis and Preparative Chemistry; Jilin University; Changchun 130012; China College of Chemistry and Molecular Sciences, Hubei Key Laboratory of Electrochemical Power Sources Wuhan University Wuhan 430072 China Diabetes Unit, National Center for Complementary and Alternative Medicine, National Institutes of Health, Bethesda; Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States. Faculty of Forensic Medicine, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510089, China. Institute of Material Medica/Guangdong Provinical Key Laboratory of Advanced Drug Delivery, Guangdong Pharmaceutical University, Guangzhou 510006, China. chenhuicherry1987@163.com Department of Orthopedics, Dalian Medical University, Dalian, Liaoning 116000, P.R. China School of Pharmacy, University of Pittsburgh, Pittsburgh, PA 15261, USA State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Key Laboratory for Bio-Nanotechnology and Molecular Engineering of Hunan Province, Hunan University, Changsha 410082, P. R. China College of Animal Science and Technology, Hunan Agricultural University, Changsha Hunan 410128, China Department of Pharmacology (The State‐Province Key Laboratories of Biomedicine‐Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), College of Pharmacy Harbin Medical University Harbin China Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu 610041, China. Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education (Sichuan University), Chengdu 610041, China. Department of Endocrinology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou510150, China Key Laboratory of Systems Biomedicine (Ministry of Education) of Rui-Jin Hospital; Shanghai Jiao Tong University School of Medicine; Shanghai China; Shanghai-MOST Key Laboratory for Disease and Health Genomics; Chinese National Human Genome Center at Shanghai; Shanghai China Department of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China; Chinese Glioma Cooperative Group (CGCG), Beijing 100050, China Ningbo Key Laboratory of Agricultural Germplasm Resources Mining and Environmental Regulation, College of Science and Technology, Ningbo University, Cixi 315300, China Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Soochow UniversitySuzhou 215006, Jiangsu Province, China; Department of General Surgery, The People's Hospital of Binhai CountyBinhai 224500, Jiangsu Province, China. Department of Gastroenterology Binzhou People's Hospital Binzhou China Department of Gastroenterology Affiliated Hospital of Jiangsu University Jiangsu University Zhenjiang China Department of Obstetrics and Gynecology, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China. Chenhui175@163.com Department of Orthodontics, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration, Jinan, SD, China Cell-Gene Therapy Translational Medicine Research Center, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China COMOC-Center for Ordered Materials Organometallics and Catalysis Department of Chemistry Ghent University Krijgslaan 281 Building S3 9000 Ghent Belgium Vascular Biology Research Institute, Guangdong Pharmaceutical University, Guangzhou, China Key Laboratory of Artificial Micro‐ and Nano‐structures of Ministry of Education School of Physics and Technology Wuhan University Wuhan 430072 China Department of Gastroenterology, Changhai Hospital, Second Military Medical University, Shanghai, China College of pharmacy Henan University of Chinese Medicine Zhengzhou China Division of Engineering in Medicine Department of Medicine Brigham and Women's Hospital and Harvard Medical School Boston MA 02139 USA Department of Chemistry, Institute of Theoretical and Computational Chemistry, Lab of Mesoscopic Chemistry, Nanjing University, Nanjing, 210093, P. R. China Department of Botany, The University of Hong Kong, Pokfulam Road, Hong Kong Department of Endocrinology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou 510150, China Beijing National Laboratory of Molecular Sciences, CAS Key Laboratory of Molecular Recognition and Function, ‡CAS Key Laboratory of Photochemistry, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China National Key Laboratory of Medical Immunology, The Second Military Medical University, Shanghai 200082, China. Department of Digestion Medicine, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China. chenhui680804@163.com Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Analytical Chemistry for Living Biosystems and Photochemistry, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China; University of Chinese Academy of Sciences, Beijing 100049, China Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, New York Department of Gastroenterology and General Surgery, Sichuan Mianyang 404 Hospital , 621000 , Mianyang , Sichuan , China West China Second University Hospital, West China Women's and Children's Hospital; Department of Obstetrics and Gynecology; No. 17, Section Three, Ren Min Nan Lu Avenue Chengdu Sichuan China 610041 State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, Guangdong, People’s Republic of China Shenzhen Grubbs Institute and Department of Chemistry Southern University of Science and Technology Shenzhen 518055 China; Academy for Advanced Interdisciplinary Studies and Department of chemistry Southern University of Science and Technology Shenzhen 518055 China Renmin Hospital of Wuhan University, Wuhan, Hubei, China 1Division of Anti-Tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.; 2University of Chinese Academy of Sciences, Beijing, China. Department of Medicinal Chemistry, School of Pharmacy, Fourth Military Medical University, Xi’an 710032, Shaanxi, China Betta Pharmaceuticals Co., Ltd, Hangzhou, Zhejiang, 311100, China Beijing Advanced Innovation Center for Materials Genome Engineering & Department of Materials Science and Engineering College of Engineering, Peking University, Beijing 100871, People’s Republic of China College of Electrical Engineering and Automation, Shandong University of Science and Technology, Qingdao, Shandong Province, 266590, P. R. China NHC Key Laboratory of Combined Multi‐Organ Transplantation Hangzhou China Tianjin Key Laboratory of Organic Solar Cells and Photochemical Conversion, Tianjin Key Laboratory of Drug Targeting and Bioimaging, School of Chemistry and Chemical Engineering, Tianjin University of Technology, No. 391 Binshuixi Road, Tianjin, 300384, China Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104; State Key Laboratory of Conservation and Utilization of Subtropical Agro‐Bioresources, Lingnan Guangdong Laboratory of Modern Agriculture, Guangdong Key Laboratory for Innovative Development and Utilization of Forest Plant Germplasm, College of Forestry and Landscape Architecture, South China Agricultural University Guangzhou 510642 China School of Chemistry and Chemical Engineering, Institute of Theoretical and Computational Chemistry, Lab of Mesoscopic Chemistry, Nanjing University, Nanjing 210093, P. R. China Department of Pathology School of Basic Medical Science Central South University Changsha China Basic Medical College, Nanjing University of Chinese Medicine, Nanjing 210023, China. College of Life Science Sichuan Agricultural University Ya'an China Key Lab of Process Analysis and Control of Sichuan Universities, Yibin University, Yibin, Sichuan 644000, China; Hospital, Yibin University, Yibin, Sichuan 644000, China Physical Education, Chinese Culture University, Taipei, Taiwan; and Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States Lawrence Livermore National Laboratory 3 Physics Division, , Livermore, California 94550, USA Hypertension-Endocrine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, Laboratory of Medicinal Chemistry, Division of Basic Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, and Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York 10461 School of Life Sciences, Faculty of Science University of Technology Sydney Sydney Australia Department of Geriatric Gastroenterology, First Affiliated Hospital, Guangxi Medical University, Nanning 530021, China. Email: chenhui680804@163.com. Department of Endocrinology, Genetics and Metabolism Beijing Children's Hospital Capital Medical University National Center for Children's Health Beijing China Division of Gastroenterology and Liver Diseases, USC Research Center for Liver Diseases, USC–UCLA Research Center for Alcoholic Liver and Pancreatic Diseases, Keck School of Medicine USC, Los Angeles, CA 90033, U.S.A. Jiangsu Key Laboratory for Biodiversity and Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing 210023, China Beijing Key Laboratory for Optical Materials and Photonic Devices Department of Chemistry Capital Normal University Beijing 100048 China Diabetes Unit (H.-W.L., R.M., H.C., M.J.Q.), National Center for Complementary and Alternative Medicine, National Institutes of Health, Bethesda, Maryland 20892 Xinxiang Medical University, China Department of Urology, Renmin Hospital of Wuhan University, Wuhan 430060, China The First Affiliated Hospital of Henan University of Chinese Medicine Zhengzhou China Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Photochemistry, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China Key Laboratory of Ecology of Rare and Endangered Species and Environmental Protection (Guangxi Normal University), Ministry of Education, Guilin 541004, China; Guangxi Key Laboratory of Rare and Endangered Animal Ecology, College of Life Science, Guangxi Normal University, Guilin 541004, China College of Forestry Northwest A&F University Yangling Shaanxi China; State Key Laboratory for Conservation and Utilization of Subtropical Agro‐Bioresources (South China Agricultural University), College of Forestry and Landscape Architecture South China Agricultural University Guangzhou China Department of Gastroenterology, People’s Hospital of Taizhou, 399 Hailing Road, Taizhou, Jiangsu 225300, China Deparment of Plastic Surgery and Burn, Tangdu, Hospital, The Fourth Military Medical University Xi'an 710038, China. COMOC—Center for Ordered Materials Organometallics and Catalysis Department of Chemistry Ghent University Krijgslaan 281, building S3 9000 Ghent Belgium University of Hong Kong, PRC (Y. Cai, H.C., Y. Cheng, Y. Guo, M.Y.K.L., S.W.S.L., S.C.L., J.T.C.L., K.W.Y.S., E.H.C.T., K.H.K.W., Q.Z.) General Surgery Department Shandong Provincial Hospital Affiliated to Shandong University Ji'nan Shandong China Digestive Endoscopy Center, Changhai Hospital, The Second Military Medical University, Shanghai, China Department of Immunology, CAMS Key Laboratory T Cell and Cancer Immunotherapy, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical College, State Key Laboratory of Medical Molecular Biology, Beijing 100005, China; Changzhou Xitaihu Institute for Frontier Technology of Cell Therapy, Changzhou 213000, China; Haihe Laboratory of Cell Ecosystem, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300010, China Chinese Academy of Sciences 2 Beijing National Laboratory for Molecular Sciences, Key Laboratory of Photochemistry, Institute of Chemistry, , Beijing 100190, People’s Republic of China Department of Lung Cancer Tianjin Medical University Cancer Institute and Hospital National Clinical Research Center for Cancer Key Laboratory of Cancer Prevention and Therapy Tianjin's Clinical Research Center for Cancer Tianjin Lung Cancer Center Tianjin China Reproductive Medicine Center, Sun Yat‐sen Memorial Hospital Sun Yat‐sen University Guangzhou China; Guangdong Provincial Clinical Research Center for Obstetrical and Gynecological Diseases China The Affiliated Infectious Hospital of Soochow University, Suzhou, China. Department of Radiology; West China Hospital; Sichuan University; Chengdu Sichuan P.R. China College of Chemistry, Key Laboratory of Molecule Synthesis and Function Discovery (Fujian Province University), Fuzhou University, Fuzhou, Fujian 350116, China Department of Gastroenterology Gongli Hospital, The Second Military Medical University Shanghai China; Digestive Endoscopy Center Changhai Hospital, The Second Military Medical University Shanghai China Institute of Chemistry and The Lise Meitner-Minerva Center for Computational Quantum Chemistry, The Hebrew University of Jerusalem, Givat Ram Campus, 91904 Jerusalem, Israel, and Department of Biomolecular Mechanisms, Max Planck Institute for Medical Research, Jahnstrasse 29, 69120 Heidelberg, Germany State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry, Jilin University, 2699 Qianjin Street, Changchun 130012, China Department of Oncology, The First People's Hospital of Tianmen, Tianmen, Hubei 431700, P.R. China Graduate School of Southern Medical University, Guangzhou, China. doc.chenhui@163.com Hemodialysis center Department of Nephrology and National Clinical Research Center for Geriatrics West China Hospital Sichuan University Chengdu China; West China School of Nursing Sichuan University Chengdu China Research Institute of Millimeter Wave and Terahertz Technology(RIMMATT) Department of Ophthalmology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA. Key Laboratory of Artificial Micro- and Nano-structures of Ministry of Education, School of Physics and Technology, Wuhan University, Wuhan 430072, People's Republic of China State Key Laboratory of Inorganic Synthesis and Preparative Chemistry College of Chemistry Jilin University Changchun 130012 P. R. China Department of Nephrology, Ruijin Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai 200025, P.R. China School of Public Health, the Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou Zhejiang China Department of Cardiovascular Medicine, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, P.R. China Department of Pharmacy Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences Guangzhou China; Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital Guangdong Academy of Medical Sciences Guangzhou China From the Department of Plastic and Reconstructive Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University, School of Medicine, No. 639 Zhizaoju Rd, Shanghai 200011, China (Y.J., Y.Z., C.H., H.C., X.Y., G.M., L.C., Y.Q., D.L., T.W., S.J.C., C.Q., X.L.); Department of Pediatric Surgery, Taizhou Hospital, Wenzhou Medical University, Taizhou, China (C.L.); and Department of Plastic, Reconstructive, Aesthetic and Hand Surgery, University Hospital Basel, Basel, Switzerland (M.T.). Shengli Clinical Medical College of Fujian Medical University, Fuzhou, China; and; Hypertension Laboratory, Fujian Provincial Cardiovascular Disease Institute, Fujian Provincial Hospital, Fuzhou, China. State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou, 350106, P. R. China; Qingyuan Innovation Laboratory, Quanzhou, 362801, P. R. China Beijing National Laboratory for Molecular Sciences and CAS Key Laboratory of Molecular Recognition and Function Institute of Chemistry Chinese Academy of Sciences (CAS) Beijing 100190 P.R. China College of Forestry Northwest A&F University Yangling Shaanxi China College of Forestry, Fujian Agriculture and Forestry University, Fuzhou, PR China Department of Pediatric Surgery, Guizhou Provincial People’s Hospital, Guiyang, Guizhou, China (mainland) Department of Joint Surgery, Orthopaedics Center, Lanzhou General Hospital of PLA, Lanzhou 730050, China. Department of Orthopedics, Clinical Medical College of Yangzhou University, Yangzhou, Jiangsu, China Heart Center of Henan Provincial People’s Hospital, Central China Fuwai Hospital Central China Fuwai Hospital of Zhengzhou University Zhengzhou Henan China Department of Liver Diseases and Digestive Interventional Radiology, National Clinical Research Center for Digestive Diseases and Xijing Hospital of Digestive Diseases Fourth Military Medical University Xi’an China Department of TCM and Rheumatology, Shenzhen Nanshan Hosiptal, Shenzhen, Guangdong 518052, China. State Key Laboratory of Chemistry and Utilization of Carbon Based Energy Resources, College of Chemistry, Xinjiang University, Urumqi 830017, China State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, PR China School of Public Health, Zhejiang University School of Medicine , 866 Yuhangtang Rd, Hangzhou 310058 , China Department of Organic Chemistry and the Lise Meitner-Minerva Center for Computational Quantum Chemistry, The Hebrew University of Jerusalem, Givat Ram Campus, 91904 Jerusalem, Israel State Key Laboratory of Structural Chemistry; Fujian Institute of Research on the Structure of Matter; The Chinese Academy of Sciences; Fuzhou; China 1State Key Laboratory of Proteomics, Beijing Institute of Radiation Medicine, Beijing, China; 2State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing, China Key Laboratory of Zoological Systematics and Evolution, Institute of Zoology, Chinese Academy of Sciences, Beijing; Human Genetics, Genome Institute of Singapore, A*STAR, Singapore Department of Chemical and Materials Engineering, National Central University, 300 Jhongda Road, Jhongli 32001, Taiwan Department of Otolaryngology-Head & Neck Surgery, Eye & ENT Hospital of Fudan University, Shanghai, 200031, PR China Key Laboratory of Artificial Micro‐ and Nano‐Structures of Ministry of Education School of Physics and Technology Wuhan University Wuhan 430072 China State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry, Jilin University, 2699 Qianjin Street, Changchun, Jilin 130012, China Department of Chemistry, Peking University, 100871, Beijing, China Department of Plastic and Reconstructive Surgery Shanghai Ninth People’s Hospital Shanghai Jiao Tong University School of Medicine Shanghai China; Department of Laser and Aesthetic Medicine Shanghai Ninth People’s Hospital Shanghai Jiao Tong University School of Medicine Shanghai China School of Pharmacy, University of Pittsburgh Tea Research Institute Chinese Academy of Agricultural Sciences Hangzhou China; Key Laboratory of Tea Quality and Safety Control Ministry of Agriculture and Rural Affairs Hangzhou China; Graduate School of Chinese Academy of Agricultural Sciences Beijing China Department of Urology Renmin Hospital of Wuhan University Wuhan China State Key Laboratory of Inorganic Synthesis and Preparative Chemistry College of Chemistry Jilin University 130012 Changchun China Key Laboratory of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China Department of Dermatology Wuhan No.1 Hospital Wuhan China Department of Pathology and Laboratory Medicine The University of Texas MD Anderson Cancer Center Houston Texas College of Forestry, Northwest A&F University, Yangling 712100, Shaanxi, People’s Republic of China. Department of Gastroenterology Chongqing University Cancer Hospital School of Medicine Chongqing University Chongqing China Department of Hematology, The Military General Hospital of Beijing PLA, Beijing, China (mainland) Department of Oral Health Sciences Faculty of Dentistry, University of British Columbia, Vancouver, Canada School of Life SciencesFaculty of ScienceUniversity of Technology SydneySydneyNew South WalesAustralia Department of Obstetrics and Gynecology, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, Guangdong Province, China;; Center for Disease Model Animals, Sun Yat-sen University, Guangzhou, China, Guangzhou, Guangdong Province, China The Institute of Pharmacology; Key Laboratory of Preclinical Study for New Drugs of Gansu Province; School of Basic Medical Sciences; Lanzhou University; Lanzhou 730000 School of Food Science and Technology; National Engineering Research Center of Seafood; Dalian Polytechnic University; Dalian, 116034; China Department of Biological Sciences, University of Maryland, Baltimore County, Baltimore, Maryland 21250, USA. Institut de Recherche de Chimie Paris, UMR8247, CNRS, Chimie ParisTech, PSL Université Paris, 11 rue Pierre et Marie Curie, 75005 Paris, France Key Laboratory of Standardization of Chinese Herbal Medicine; State Key Laboratory Breeding Base of Systematic Research; Development and Utilization of Chinese Medicine Resources; Ministry of Education; College of Pharmacy Department of Clinical Laboratory Xinhua Hospital Shanghai Jiao Tong University School of Medicine Shanghai China Diabetes Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health Bethesda, Maryland Clinical Laboratories, The First Affiliated Hospital of Chongqing Medical University, China From the Department of Plastic and Reconstructive Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine; and the Institute for Social and Economic Research and Policy, Graduate School of Arts and Science, Columbia University. State Key Laboratory of Solidification Processing Center for Nano Energy Materials School of Materials Science and Engineering Northwestern Polytechnical University Xi'an 710072 P. R. China Department of Neurology, Military General Hospital of Beijing PLA, Beijing 100700, China Department of Pathology and Laboratory Medicine, University of Pennsylvania , Philadelphia, PA, USA Faculty of Science, School of Life Sciences University of Technology Sydney Sydney New South Wales Australia Institute of Clinical Pharmacology, Tongji Medical College of Huazhong University of Science and Technology College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China; Collaborative Innovation Center for Respiratory Disease Diagnosis and Treatment & Chinese Medicine Development of Henan Province, Zhengzhou 450046, China Institute of Physics & University of Chinese Academy of Sciences, Chinese Academy of Sciences, P.O. Box 603, Beijing 100190, China State Key Laboratory of Proteomics Beijing Proteome Research Center National Center for Protein Sciences (Beijing) Beijing Institute of Lifeomics China Department of Gastroenterology, Gongli Hospital; Department of Gastroenterology, Changhai Hospital, The Second Military Medical University, Shanghai Shanghai Key Laboratory of Regulatory Biology; School of Life Sciences; East China Normal University; Shanghai; P. R. China Guangdong Provincial Key Laboratory of Nutraceuticals and Functional Foods, College of Food Science, South China Agricultural University, Guangzhou 510642, China College of Life Science, Sichuan Agricultural University, Ya’an, Sichuan, China Institute of Physics & University of Chinese Academy of Sciences, Chinese Academy of Sciences, Beijing 100190, P. R. China Saban Research Institute Children's Hospital Los Angeles CA USA Key Laboratory of Environmental Biology and Pollution Control (Hunan University), Ministry of Education, Lushan South Road, Yuelu District, Changsha 410082, P.R. China School of Life Sciences, Faculty of ScienceUniversity of Technology SydneySydney New South WalesAustralia School of Computers, Guangdong University of Technology, Guangzhou, China School of Chemical & Materials Engineering; Key Laboratory of Food Colloids and Biotechnology Ministry of Education; Jiangnan University; Wuxi 214122; P. R. China Shanghai Key Laboratory of Green Chemistry and Chemical Processes, College of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062, China School of Biomedical Engineering Capital Medical University Beijing China Department of Cardiology Renmin Hospital of Wuhan University Wuhan China; Cardiovascular Research Institute Wuhan University Wuhan China Department of Otolaryngology, Wang Jing Hospital of CACMS, Beijing, PR China Department of Plastic and Reconstructive Surgery, Shanghai Ninth People’s Hospital Shanghai Jiao Tong University School of Medicine, Shanghai, China Evidence-based Medicine Section, Department of Research and Education, Guizhou Province People's Hospital, Guiyang 550002, China. *Corresponding author, E-mail: huichen7710@hotmail.com. Division of Chemistry and Biological Chemistry; School of Physical and Mathematical Sciences; Nanyang Technological University; Singapore 637371, Singapore Xijing Hospital of Digestive Diseases Fourth Military Medical University Xi'an China Key Laboratory for Advanced Materials and Institute of Fine Chemicals East China University of Science & Technology Shanghai 200237 P. R. China Department of Chemistry, Soochow University, Suzhou 215006, China. Department of Hepatology, Hepatobiliary Hospital of Jilin, Changchun, People’s Republic of China Pharmacy School, Guilin Medical University, Guilin 541004, People’s Republic of China Department of Chemical Engineering, Nanjing Forestry University, Nanjing, Jiangsu, P. R. China Institute of Systems and Physical Biology, Shenzhen Bay Laboratory , Shenzhen 518055, China State Key Laboratory of Oral Diseases, Sichuan University, Chengdu, China; Department of Operative Dentistry and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China The Cancer Center of the Fifth Affiliated Hospital of Sun Yat‐sen University Zhuhai China Department of Nephrology, Ruijin Hospital, Shanghai Jiao Tong University, School of Medicine Triple Ring Technologies, Newark, California Department of Chemistry, Tsinghua University, Beijing 100084, China, and State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing 100029, China School of Life Sciences, Faculty of Science, University of Technology, Sydney, New South Wales, Australia. BNLMS CAS Key Laboratory of Photochemistry Institute of Chemistry Chinese Academy of Sciences Beijing 100190 China State Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic & Developmental Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China; and Provincial Clinical College of Fujian Medical University, Fujian Provincial Institute of Cardiovascular Disease, Fuzhou 350001. chen.hui@medmail.com.cn Department of Cardiovascular Medicine, The Third Affiliated Hospital of Nanchang University Beijing National Laboratory for Molecular Sciences (BNLMS); CAS Key Laboratory of Photochemistry Institute of Chemistry; Chinese Academy of Sciences; Beijing; China Diabetes Unit (R.M., M.I., H.C., P.P., M.J.Q.), National Center for Complementary and Alternative Medicine, National Institutes of Health, Bethesda, Maryland 20892; Institute of Physics and University of Chinese Academy of Sciences Chinese Academy of Sciences Beijing 100190 China; Beijing National Laboratory for Condensed Matter Physics Chinese Academy of Sciences Beijing 100190 China E-mail: chenhui@ccmu.edu.cn. Department of Endocrinology The Third Affiliated Hospital of Guangzhou Medical University Guangzhou Guangdong China Lawrence Livermore National Laboratory 1 , Livemore, California 94551, USA London Research and Development Centre, Agriculture and Agri-Food Canada, London, Ontario, Canada; Department of Biology, University of Western Ontario, London, Ontario, Canada Department of Anesthesiology and Perioperative Medicine, Shanghai Fourth People's Hospital Affiliated to Tongji University School of Medicine Shanghai 200434, China. Department of Pediatrics, Second Affiliated Hospital, Tianjin University of Traditional Chinese Medicine, Tianjin 300150, China. Laboratory Animal Institute Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital University of Electronic Science and Technology of China Chengdu China Department of Oncology and Hematology, People's Hospital of Leshan Xiamen University Chemistry 422 Siming South Road, Siming District, Xiamen City, Fujian Province 361005 Xiamen CHINA Faculty of Life Science, Northwest University, Xi’an, China Department of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, China First Clinical Medical College of Guizhou University of TCM, Guiyang 550002, China. Department of Internal Medicine, Fujian Provincal Cardiovascular Disease Institute, Provincial Clinical College of Fujian Medical University, 134 East Street, Fuzhou, Fujian 350001, P.R. China Department of Burns and Plastic Surgery, Beijing Jishuitan Hospital, Beijing 100035, China State Key Laboratory of Inorganic Synthesis and Preparative Chemistry College of Chemistry Jilin University Changchun 130012 China From the Diabetes Unit, National Center for Complementary and Alternative Medicine, National Institutes of Health, Bethesda, Maryland Department of Anatomical and Cellular Pathology,The Chinese University of Hong Kong,Shatin,Hong Kong,China Clinical Medical Collage of Yangzhou University, North Jiangsu People's Hospital Yangzhou China Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China; and Department of Radiology, Neuroradiology Division, Stanford University, Stanford, CA, USA Key Laboratory of Acupuncture and Medicine Research of Ministry of Education, Nanjing University of Chinese Medicine, Xianlin Road 138, Qixia Street, Nanjing, Jiangsu 210023, China Department of Gastrointestinal Surgery The First Affiliated Hospital Fujian Medical University Fuzhou China Dept. of Clinical Medicine Xuzhou Medical College Xuzhou 221004 Jiangsu China Department of Oral Radiology Academic Centre for Dentistry Amsterdam (ACTA) University of Amsterdam VU University Amsterdam Amsterdam The Netherlands; Department of Oral Kinesiology Academic Centre for Dentistry Amsterdam (ACTA) MOVE Research Institute Amsterdam University of Amsterdam VU University Amsterdam Amsterdam The Netherlands Diabetes Unit (G.F., H.C., J.-a.K., M.J.Q.), National Center for Complementary and Alternative Medicine, National Institutes of Health, Bethesda, Maryland 20892; Beijing National Laboratory for Molecular Sciences (BNLMS); Key Laboratory of Photochemistry; Institute of Chemistry; Chinese Academy of Sciences; Beijing 100190 Department of Maternal and Child Health, School of Public Health, Tongji Medical College in Huazhong University of Science and Technology, Wuhan, China. chenhui2288@hotmail.com Advanced Photonics Center, Southeast University Nanjing 210096 China College of Life Science, Sichuan Agricultural University, 46 Xinkang Road, Ya’an, Sichuan 625014, China College of Forestry and Landscape Architecture, South China Agricultural University, Guangzhou 510642, Guangdong, People’s Republic of China. Department of Cardiovascular Medicine, The Third Affiliated Hospital of Nanchang University, The First Hospital of Nanchang, Nanchang City, Jiangxi Province, China Beijing Key Laboratory of Microanalytical Methods and Instrumentation, Department of Chemistry, Tsinghua University, Beijing 100084, People’s Republic of China Department of Pharmaceutical Sciences and Computational Chemical Genomics Screening Center, School of Pharmacy, and National Center of Excellence for Computational Drug Abuse Research, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, United States State Key Laboratory of Chemo/Biosensing and Chemometrics College of Biology College of Chemistry and Chemical Engineering Key Laboratory for Bio-Nanotechnology and Molecular Engineering of Hunan Province Hunan University Changsha 410082 P. R. China Reproductive Medicine Center, Sun Yat-sen Memorial Hospital , Sun Yat-sen University , Guangzhou , Guangdong Province , China CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Zhangjiang Hi-Tech Park, Shanghai 201203, People’s Republic of China; College of Pharmacy, Nanchang University, Nanchang 330006, People’s Republic of China Department of Pathology, First Hospital of Changsha, Changsha 410005. Department of Radiology, Xiangyang Central Hospital Affiliated to Hubei University of Arts and Science, Xiangyang, Hubei 441021, P.R. China School of Medical and Molecular Biosciences, University of Technology, Sydney, Australia. Sino-French Hoffmann Institute, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, Guangdong, China Department of Immunology,Institute of Basic Medical Sciences,CAMS and PUMC,Beijing 100005,China. Department of Cardiovascular Medicine, the First Affiliated Hospital of Xi’an Jiao Tong University, Xi’an 710061, China State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China. State Key Laboratory of Plant Genomics, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, 100101 Beijing, China;; University of Chinese Academy of Sciences, 100049 Beijing, China;; College of Life Sciences and Oceanography, Shenzhen University, 518060 Shenzhen, China State Key Lab of Plant Genomics, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100049, China College of Horticulture Nanjing Agricultural University Nanjing Jiangsu 210095 China School of Materials and Environmental Engineering, Shenzhen Polytechnic, Shenzhen, 518055, P. R. China Clinical Epidemiology Unit Qilu Hospital of Shandong University Jinan China; Clinical Research Center of Shandong University Qilu Hospital Cheeloo College of Medicine Shandong University Jinan China Department Pathology, The University of Texas MD Anderson Cancer Center , Houston, TX , USA Institute of Materials for Energy and Environment, College of Materials Science and Engineering, Qingdao University, Qingdao 266071, China School of Materials Science & Engineering; Nanyang Technological University; Singapore University of Delaware Newark DE USA; Nemours/Alfred I. duPont Hospital for Children Wilmington DE USA Department of Chemistry, Zhejiang University, Hangzhou 310027, China Department of Pharmaceutical Sciences and Computational Chemical Genomics Screening Center, School of Pharmacy; National Center of Excellence for Computational Drug Abuse Research; Drug Discovery Institute; and Departments of Computational Biology and Structural Biology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, United States Department of Geriatrics Digestion Internal Medicine, The first Affiliated Hospital of Guangxi Medical University, Guangxi 530021 ,China. haolphd@163.com Wuhan University, China Department of Pathology, The Third Affiliated Hospital, Guangzhou Medical University Guangzhou 510150, China. Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Plastic and Reconstructive Surgery, Shanghai, China Shengli Clinical Medical College of Fujian Medical University, Fuzhou Department of Cardiology, Beijing Friendship Hospital, Capital Medical University, China Beijing National Laboratory for Molecular Sciences (BNLMS) CAS Key Laboratory of Photochemistry Institute of Chemistry Chinese Academy of Sciences Beijing 100190 China Temasek Laboratories Nanyang Technological University 50 Nanyang Drive Singapore 637553 Singapore Department of Laboratory Medicine, Jiangxi provincial People's Hospital Affiliated to Nanchang University , Nanchang 330006 , China Division of Ocean Science and Technology, Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, China; College of the Environment and Ecology, Xiamen University, Xiamen, Fujian 361005, China Department of Gastroenterology, Hunan Provincial People's Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha, People’s Republic of China Department of PathologySir Run Run Shaw HospitalZhejiang University School of MedicineZhejiang UniversityHangzhouChina Department of Orthopaedic, BenQ Medical Center, The Affilicated BenQ Hospital of Nanjing Medical University, 210019, Nanjing, Jiangsu Province, China College of Life Sciences, Sichuan Agricultural University, Ya’an, China Department of Conservative Dentistry and Periodontics; Affiliated Hospital of Stomatology; Medical College; Zhejiang University; Hangzhou Department of Critical Care Medicine, The First Affiliated Hospital of Soochow University, Soochow University Suzhou 215000, Jiangsu, China. Department of Orthodontics, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University and Shandong Key Laboratory of Oral Tissue Regeneration and Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration, Shandong, China; Faculty of Dental Medicine, University of Montreal, Montreal, Quebec, Canada Centre de Recherche des Cordeliers, Equipe labellisée par la Ligue contre le cancer, Inserm U1138, Université Paris Cité, Sorbonne Université, Institut Universitaire de France, Paris, France. Metabolomics and Cell Biology Platforms, UMS AMICCa, Gustave Roussy, Villejuif, France. Faculté de Médecine, Université de Paris Saclay, Kremlin Bicêtre, France. Epigenetic Editing, Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Hanzeplein1, 9713 GZ Groningen, The Netherlands, 2The State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 200031, China and 3Synvolux Therapeutics Inc., LJ. Zielstraweg 1, 9713 GX Groningen, The Netherlands; Epigenetic Editing, Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Hanzeplein1, 9713 GZ Groningen, The Netherlands, 2The State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 200031, China and 3Synvolux Therapeutics Inc., LJ. Zielstraweg 1, 9713 GX Groningen, The Netherlands College of Chemistry and Molecular Sciences Hubei Key Laboratory of Electrochemical Power Sources Wuhan University Wuhan 430072 P. R. China University of Electronic Science and Technology of China 1 School of Electronic Engineering, , Chengdu 611731, People’s Republic of China Diabetes Unit, National Center for Complementary and Alternative Medicine, National Institutes of Health, Bethesda, Maryland State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China School of Life Science and Engineering, Southwest Jiaotong University Chengdu, China Department of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China; National Clinical Research Center on Mental Disorders, Changsha, Hunan, China; National Technology Institute on Mental Disorders, Changsha, Hunan, China; Hunan Key Laboratory of Psychiatry and Mental Health, Changsha, Hunan, China Beijing National Laboratory for Molecular Sciences, Key Laboratory of Photochemistry, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China State Key Laboratory of Plant Physiology and Biochemistry, College of Biological Sciences China Agricultural University Beijing 100193 China From the Weis Center for Research, Geisinger Health System, Danville, PA; and the Department of Biological and Allied Health Sciences, Bloomsburg University, Bloomsburg, PA. Shanghai University, Shanghai 200072, China. Ministry of Education Key Laboratory for Analytical Science of Food Safety and Biology, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, College of Chemistry, Fuzhou University, Fuzhou, Fujian, 350116, China Department of Cardiovascular Center, Friendship Hospital, Beijing, China; Yunting Liang and Hui Chen are the co-first authors. Department of Orthopaedics, Zhongda Hospital, School of Medicine Southeast University Nanjing China; Multidisciplinary Team (MDT) for Geriatric Hip Fracture Management, Zhongda Hospital School of Medicine, Southeast University Nanjing China; School of Medicine Southeast University Nanjing China; Orthopaedic Trauma Institute (OTI) Southeast University Nanjing China; Trauma Center, Zhongda Hospital, School of Medicine Southeast University Nanjing China Department of Obstetrics and Gynecology, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China (mainland). Department of Microbiology and Immunology, Georgetown University School of Medicine, Washington District of Columbia, USA; CMRS/Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA Department of Orthodontics, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration, Jinan, China Mass Spectrometry Core Research Resource Center Office of Vice Chancellor for Research University of Illinois at Chicago Chicago IL USA Key Laboratory of Behavioral Science, Institute of Psychology, Chinese Academy of Sciences College of Science; Shenyang University of Chemical Technology; Shenyang 110142; China State Key Laboratory of Ophthalmology Zhongshan Ophthalmic Center, Sun Yat‐sen University Guangzhou Guangdong China; Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science Guangzhou Guangdong China; Guangdong Provincial Clinical Research Center for Ocular Diseases Guangzhou Guangdong China Key Laboratory for Green Processing of Chemical Engineering of Xinjiang Bingtuan, School of Chemistry and Chemical Engineering, Shihezi University, Shihezi 832003, P. R. China Department of Anesthesiology, Changhai Hospital, Second Military Medical University, Shanghai 200433, P.R. China College of Animal Science and Technology, Hebei Agricultural University, Baoding 071001, China; Key Laboratory of Broiler and Layer Facilities Engineering, Ministry of Agriculture and Rural Affairs, Baoding 071001, China State Key Laboratory of Analytical Chemistry for Life Science, Jiangsu Key Laboratory of Advanced Organic Materials, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China Hubei Provincial Center for Disease Control and Prevention. Heilongjiang Hongqiao Hospital, Harbin, People's Republic of China School of Biomedical Engineering Capital Medical University Beijing China; Beijing Key Laboratory of Fundamental Research on Biomechanics in Clinical Application Capital Medical University Beijing China Department of Cardiology, Cardiovascular Center, Beijing Friendship Hospital, Capital Medical University, Beijing, P. R. China Key Laboratory of Leather Chemistry and Engineering of Ministry of Education, Sichuan University, Chengdu 610065, P. R. China Equipe labellisée par la Ligue contre le cancer, Université de Paris, Sorbonne Université, INSERM UMR1138, Centre de Recherche des Cordeliers, Paris, France; Metabolomics and Cell Biology Platforms, Gustave Roussy Cancer Campus, Villejuif, France; Université Paris Sud, Paris Saclay, Faculty of Medicine, Kremlin Bicêtre, France. Zhejiang Avocado Biotechnologies Co., Ltd, Yuyao 315412, China Division of Chemistry and Biological Chemistry; School of Physical and Mathematical Sciences; Nanyang Technological University; Singapore 637371; Singapore Department of Ultrasound, Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, P.R. China Medical Affairs 3D Medicines Inc. Shanghai China Nanjing University Department of Chemistry, Institute of Theoretical and Computational Chemistry, Laboratory of Mesoscopic Chemistry, , Nanjing 210093, People’s Republic of China College of Forestry, Northwest A & F University State Key Laboratory of Ophthalmology Zhongshan Ophthalmic Center Sun Yat‐sen University Guangzhou China Beijing National Laboratory for Molecular Sciences (BNLMS), CAS Key Laboratory of Photochemistry, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China Department of Environmental Science and Engineering, Fudan University, Shanghai 200438, China. Anethesiology department, Changhai hospital, Second Military Medical University, Shanghai, 200433, People's Republic of China. Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine The University of Hong Kong Hong Kong SAR China Key Laboratory of Meteorological Disaster, Ministry of Education(KLME), Joint International Research Laboratory of Climate and Environment Change(ILCEC), Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters(CIC-FEMD), Key Laboratory for Aerosol-Cloud-Precipitation of China Meteorological Administration, Nanjing University of Information Science and Technology, Nanjing 210044, China. Geriatrics Digestion Department of Internal Medicine, The First Affiliated Hospital of Guangxi Medical University, Nanning, PR China; Guangxi Key Laboratory of AIDS Prevention and Treatment & Guangxi Universities Key Laboratory of Prevention and Control of Highly Prevalent Disease, Nanning, 530021, Guangxi, PR China Jiangxi University of Traditional Chinese Medicine College of Plant Protection Nanjing Agricultural University Nanjing 210095 China *State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing 102206, China; and Pharmacy School Guilin Medical University Guilin 541004 People's Republic of China Department of Organic Chemistry and The Lise Meitner-Minerva Center for Computational Quantum Chemistry, The Hebrew University of Jerusalem, 91904 Jerusalem, Israel, and Max-Planck-Institut für Kohlenforschung, Kaiser-Wilhelm-Platz 1, 45470 Mülheim an der Ruhr, Germany Department of Pediatrics, Rizhao City Traditional Chinese Medicine Hospital, Rizhao, Shandong 276800, P.R. China School of Chemistry and Materials Science, Hunan Agricultural University, Changsha, Hunan 410128, China Ningxia Hui Autonomous Region Center for Disease Control and Prevention, Yinchuan City, Ningxia Hui Autonomous Region Yinchuan People's Republic of China The Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology, Department of Chemistry, Tsinghua University, Beijing 100084, China Breast Surgery Department, Affiliated Fuzhou First Hospital of Fujian Medical University, Fuzhou 350009, China State Key Laboratory of Analytical Chemistry for Life Science, Jiangsu Key Laboratory of Advanced Organic Materials, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Chemistry and Chemical Engineering, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China Hematologic Disease Laboratory, Hematology Center, Beijing Key Laboratory of Pediatric Hematology Oncology, National Key Discipline of Pediatrics (Capital Medical University), Key Laboratory of Major Diseases in Children, Ministry of Education, Beijing Pediatric Research Institute, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, China Department of Plastic and Reconstructive Surgery Shanghai Ninth Peoples Hospital Affiliated to Shanghai Jiaotong University School of Medicine Shanghai China; Department of Laser and Aesthetic Medicine Shanghai Ninth Peoples Hospital Affiliated to Shanghai Jiaotong University School of Medicine Shanghai China College of Forestry, Fujian Agriculture and Forestry University, Fuzhou, China School of Energy Science and Engineering; Nanjing Tech University; Nanjing; China Department of Pharmaceutical Sciences; Chongqing University; Chongqing; China State Key Laboratory of Electronic Thin Films and Integrated Devices, School of Optoelectronic Information, University of Electronic Science and Technology of China, Chengdu 610054, People's Republic of China College of Electrical Engineering and Automation Shandong University of Science and Technology Qingdao 266590 China Shanxi Key Laboratory of Gas Energy Efficient and Clean Utilization College of Chemical Engineering and Technology Taiyuan University of Technology Taiyuan 030024 Shanxi China College of Medicine, Jiaxing University, Jiaxing, Zhejiang, China School of Food Science and Technology, National Engineering Research Center of Seafood Dalian Polytechnic University Dalian China Department of Endocrinology, Clinical Medical College, Yangzhou University, Northern Jiangsu People’s Hospital, Yangzhou, Jiangsu, China Burns Department, Beijing Jishuitan Hospital, Beijing 100035, China. chenhuijst@126.com Institute of Rehabilitation Science of China, China Rehabilitation Research Center, Beijing, P. R. China Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, China School of Biomedical Engineering, Capital Medical University, No. 10, Xitoutiao, You An Men, Fengtai District, Beijing 100069, China; Beijing Key Laboratory of Fundamental Research on Biomechanics in Clinical Application, Capital Medical University, No. 10, Xitoutiao, You An Men, Fengtai District, Beijing 100069, China Huazhong Agricultural University Key Laboratory of Horticultural Plant Biology, Ministry of Education, College of Horticulture and Forestry Sciences, , Wuhan, 430070, P.R. China Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China; Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, Sichuan, China; Reproductive Endocrinology and Regulation Laboratory, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China Department of Neurology Chengdu Women and Children's Central Hospital Chengdu China Geriatric Medicine, Clinical Medical College of Yangzhou University, Yangzhou, PR China Shenzhen Grubbs Institute and Department of Chemistry, Southern University of Science and Technology, Shenzhen 518055, China; Academy for Advanced Interdisciplinary Studies, Southern University of Science and Technology, Shenzhen 518055, China First Affiliated Hospital of Soochow University, Suzhou, China Chongqing Key Laboratory of Natural Product Synthesis and Drug Research School of Pharmaceutical Sciences Chongqing University Chongqing 401331 P. R. China Key Laboratory of Mesoscopic Chemistry of Ministry of Education; Institute of Theoretical and Computational Chemistry; School of Chemistry and Chemical Engineering; Nanjing University; Nanjing Key Laboratory of RNA Biology; CAS Center for Excellence in Biomacromolecules; Institute of Biophysics; Chinese Academy of Sciences; Beijing 100101 Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science and Nutritional Engineering, Beijing Key Laboratory for Food Non-thermal Processing, China Agricultural University, No.17 Qinghua East Road, Haidian District, Beijing 100083, China Department of Gastroenterology, People's Hospital of Taizhou, Taizhou, Jiangsu, China. Institute of Chemistry Henan Academy of Sciences Zhengzhou 450002 P.R. China Department of Obstetrics and Gynecology Sun Yat‐sen Memorial Hospital Sun Yat‐sen University Guangzhou China Department of Pathology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX, 77030, USA. hchen7@mdanderson.org. School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, PR China School of Optoelectronic Science and Engineering, Key Laboratory of Advanced Optical Manufacturing Technologies of Jiangsu Province, Key Laboratory of Modern Optical Technologies of Education Ministry of China, Suzhou 215123, Jiangsu, People’s Republic of China Department of Respiration, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, China. Departments of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA Department of Otolaryngology–Head and Neck Surgery; and Department of Allergy Beijing TongRen Hospital, Capital Medical University Beijing China; Beijing Key Laboratory of Nasal Diseases Beijing Institute of Otolaryngology Beijing China; Department of Otolaryngology Wangjing Hospital, China Academy of Chinese Medical Science Beijing China NHC Key Laboratory of Combined Multi-Organ Transplantation, Hangzhou, China. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People’s Republic of China Department of Gerontology (H.C.), China. State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine Beijing China Department of Mathematics and Computer Science, Virginia State University, P.O. Box 9068, Petersburg, VA 23806, USA Institute of Physics, Chinese Academy of Sciences, Beijing 100190, P. R. China Department of Ophthalmology, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, School of Medicine University of Electronic Science and Technology of China Chengdu China Advanced Water Management Centre, Faculty of Engineering, Architecture and Information Technology, The University of Queensland, St. Lucia, Queensland 4072, Australia Department of Microbiology, College of Life Science, Hunan Normal University, Changsha, Hunan 410081, China Department of Immunology, School of Medicine, Yangtze University , Jingzhou, Hubei Province, People's Republic of China Department of Nephrology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China Department of Energy Plant Research Laboratory, Michigan Proteome Consortium, and Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI 48824 National Engineering Research Center of Seafood; Collaborative Innovation Center of Provincial and Ministerial Co-construction for Seafood Deep Processing; School of Food Science and Technology; Dalian Polytechnic University; Dalian Institution of Pathogenic Biology, Hengyang Medical College, University of South China, Hengyang, Hunan 421001, P.R. China Institute of Artificial Intelligence and Robotics, Xian Jiaotong University, Xian, Shaanxi 710049, P. R. China Department of Drug Metabolism, Key Laboratory of Active Substances Discovery and Drug Ability Evaluation, State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100050 People's Republic of China Clinical Epidemiology Unit Qilu Hospital of Shandong University Jinan Shandong China; Clinical Research Center of Shandong University, Qilu Hospital Cheeloo College of Medicine, Shandong University Jinan Shandong China School of Materials and Energy, National Center for International Research on Photoelectric and Energy Materials, Yunnan University, Kunming 650091, P. R. China College of Animal Science and Veterinary Medicine, Jilin University, Changchun, Jilin, China Department of Pathology and Laboratory Medicine Boston University School of Medicine Boston MA USA Department of Medicine, Betta Pharmaceuticals Co., Ltd., Hangzhou Department of Ophthalmology, Northwestern University, Evanston, Illinois; Chongqing Key Laboratory of Natural Product Synthesis and Drug Research; School of Pharmaceutical Sciences; Chongqing University; Chongqing 401331; China Department of Gastroenterology, Changhai Hospital The Second Military Medical University Shanghai China; Digestive Endoscopy Center, Changhai Hospital The Second Military Medical University Shanghai China Lawrence Livermore National Laboratory 1 , 7000 East Avenue, Livermore, California 94550-9234, USA Department of Critical Care Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, Peoples Republic of China Plastic and Reconstructive Department, Shanghai Ninth People's Hospital Shanghai China College of Life Sciences Nanjing Agricultural Univ. Nanjing Jiangsu 210095 China Department of Nephrology, Wenzhou Central Hospital, Wenzhou, Zhejiang 325000, P.R. China College of Forestry Northwest A&F University Yangling Shaanxi Department of Lung Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, China; Key Laboratory of Cancer Prevention and Therapy, Tianjin, China; Tianjin Lung Cancer Center, Tianjin, China; Tianjin’s Clinical Research Center for Cancer, Tianjin, China State Key Laboratory of Special Surface Protection Materials and Application Technology, Wuhan Research Institute of Materials Protection, Wuhan, 430030, China College of Science & Technology Ningbo University; Ningbo University; Ningbo City; China Department of Digestive Interventional Radiology, Xijing Hospital of Digestive Diseases, Fourth Military Medical University, 15 West Changle Rd, Xi’an 710032, China College of Food Science and Technology Zhejiang University of Technology Hangzhou 310014 China; Key Laboratory of Marine Fishery Resources Exploitment & Utilization of Zhejiang Province Hangzhou 310014 China; National R&D Branch Center for Pelagic Aquatic Products Processing (Hangzhou) Hangzhou 310014 China Ministry of Education Key Laboratory for Analytical Science of Food Safety and Biology, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, College of Chemistry, Fuzhou University, Fuzhou, Fujian, 350002, China Department of Plastic and Reconstructive Surgery Shanghai Ninth People's Hospital Shanghai Jiaotong University School of Medicine Shanghai China; Department of Cosmetic Laser Center Shanghai Ninth People's Hospital Shanghai Jiaotong University School of Medicine Shanghai China School of Life Sciences, Faculty of Science University of Technology Sydney Sydney New South Wales Australia From the Department of Medicine III (Cardiology) (R.R., M.F., D.I.A., K.R.K.), University of Tübingen, Tübingen, Germany; and Department of Pathology (H.C., J.L.), Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Mass. Beijing National Laboratory for Molecular Science Key Laboratory of Photochemistry Institute of Chemistry Chinese Academy of Sciences Beijing 100190 China State Key Laboratory of Proteomics Beijing Proteome Research Center National Center for Protein Sciences (Beijing) Beijing Institute of Lifeomics Beijing China Division of Oral Pathology, Beijing Institute of Dental Research, Beijing Key Laboratory, Beijing Stomatological Hospital & School of Stomatology, Capital Medical University, Beijing, China Nanjing Dongchen Pigeon Industry Co., Ltd., Nanjing 210000, China School of Life Sciences, Faculty of Science, University of Technology Sydney, Sydney, NSW, Australia. Electronic address: hui.chen-1@uts.edu.au. School of Food Science and Technology, National Engineering Research Center of Seafood, Collaborative Innovation Center of Seafood Deep Processing, Dalian Polytechnic University, Dalian 116034, China Department of Cardiovascular, Beijing Friendship Hospital, Capital Medical University Beijing 100050, China. College of Life & Science, Sichuan Agriculture University, Ya' an, Sichuan 625014. Department of Cardiology Shanghai Chest Hospital, Shanghai Jiao Tong University Shanghai People's Republic of China State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing, China College of Food Science and Engineering, Ocean University of China , Qingdao 266003 , China Department of Urology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China Department of Chemistry, Peking University, Beijing 100871, China School of Biomedical Engineering; Capital Medical University; Bejing China Department of Cell and Developmental Biology University of Pennsylvania 421 Curie Blvd, 1151 BRB II/III Philadelphia Pennsylvania 19104 School of Basic Medical Sciences, Youjiang Medical University for Nationalities, Baise, Guangxi, China Department of Radiation Oncology The First Affiliated Hospital of Nanjing Medical University Nanjing China Department of Critical Care Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China Department of Chemistry, Box 9573, Mississippi State University, Mississippi State, Mississippi 39762, and Department of Chemistry, Station B-351822, Vanderbilt University, Nashville, Tennessee 37235 Department of Surgery, Children’s Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, California Department of Nephrology, Shanghai East Hospital Tongji University School of Medicine Shanghai PR China National Research Center for Edible Fungi Biotechnology and Engineering FenXian District Shanghai People's Republic of China Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, P. R. China Key Laboratory of Design and Assembly of Functional Nanostructures, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian 350002, People’s Republic of China Manitoba Centre for Health Policy, Winnipeg, Canada. Department of Hepatobiliary and Pancreatic Surgery, The Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325035, P.R. China Department of Hepatobiliary Surgery Affiliated Hospital of North Sichuan Medical College Nanchong People's Republic of China; Institute of Hepatobiliary Pancreatic and Intestinal Disease North Sichuan Medical College Nanchong People's Republic of China Department of Neurology, Qilu Hospital of Shandong University, Shandong University, Jinan, Shandong 250012, China Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, Shanghai, PR China d Department of Chemical and Materials Engineering, National Central University, 300 Jhongda Road, Jhongli, Taoyuan 32001, Taiwan Key Laboratory of Molecule Synthesis and Function Discovery (Fujian Province University), College of Chemistry Fuzhou University Fuzhou Fujian China Department of Cardiology, Beijing Friendship Hospital, Capital Medical University College of Food Science and Engineering, Ocean University of China, Qingdao 266003, China State Key Laboratory of Inorganic Synthesis and Preparative Chemistry; College of Chemistry; Jilin University; Changchun 130012; China State and Local Joint Engineering Laboratory for Novel Functional Polymeric Materials; Suzhou Key Laboratory of Macromolecular Design and Precision Synthesis; Jiangsu Key Laboratory of Advanced Functional Polymer Design and Application; Department of Polymer Science and Engineering; College of Chemistry Department of Oral Radiology, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and Vrije Universiteit Amsterdam, Netherlands; Department of Oral Kinesiology, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and Vrije Universiteit Amsterdam, Netherlands Department of Conservative Dentistry and Periodontics, Stomatology Hospital Affiliated to Zhejiang University School of Medicine, Hangzhou, Zhejiang, China (mainland) School of Pharmaceutical Sciences, Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Beijing Advanced Innovation Center for Structural Biology, Tsinghua University, Beijing 100084, China Beijing National Laboratory for Molecular Science; Key Laboratory of Organic Solids; Institute of Chemistry; Chinese Academy of Sciences; Beijing College of Geographical Sciences Hebei Normal University Shijiazhuang 050016 Hebei China College of Electrical Engineering and Automation; Shandong University of Science and Technology; Qingdao 266590; People's Republic of China College of Food Science and Technology; Zhejiang University of Technology; Hangzhou 310014; China Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, Innovative Drug Research Center, School of Pharmaceutical Sciences, Chongqing University, Chongqing 401331, China School of Life Sciences Faculty of Science University of Technology Sydney PO Box 123 Broadway NSW 2007 Australia College of Agriculture, Guizhou University, Guiyang 550025, China; Institute of New Rural Development, Guizhou University, Guiyang 550025, China Xi’an Jiaotong University 4 , Xi’an 710049, China Department of Plastic & Reconstructive Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China Cardiology Branch (M.M., L.V.R., H.C., M.J.Q.), National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892 Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, China; and School of Chemical & Materials Engineering, Key Laboratory of Food Colloids and Biotechnology Ministry of Education, Jiangnan University, Wuxi 214122, PR China Department of Pharmacy, Chinese‐American Research Institute for Diabetic Complications Wenzhou Medical University Wenzhou China Department of Plastic and Reconstructive Surgery Shanghai Ninth People's Hospital Shanghai Jiaotong University Shanghai China; Cosmetic Laser Center Shanghai Ninth People's Hospital Shanghai Jiaotong University Shanghai China State Key Laboratory of Biomembrane and Membrane BiotechnologyInstitute of ZoologyChinese Academy of SciencesBeijingChina Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment, Chongqing University Cancer Hospital & Chongqing Cancer Institute and Chongqing Cancer Hospital, Chongqing, China. Dalian Blood Center Dalian China From the *Department of Gastroenterology, †Digestive Endoscopy Center, Changhai Hospital, The Second Military Medical University, Shanghai; ‡Department of Surgery, Jinling Hospital; §Department of Gastroenterology, Zhongda Hospital, Southeast University, Nanjing; ∥Department of Gastroenterology, Air Force General Hospital, Beijing; and ¶Department of Traditional Chinese Medicine, Jiangdu Hospital, Yangzhou, China. Department of Cardiology, Beijing Friendship Hospital, Capital Medical University, Beijing, P.R. China Hainan Medical University, Haikou, Hainan, China. Department of Ophthalmology, Sichuan Provincial People’s Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu City, Sichuan Province, China; Laboratory Animal Institute, Sichuan Provincial People’s Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu City, Sichuan Province, China Department of Linguistics, Australian Research Council Centre of Excellence in Cognition and its Disorders, Macquarie University , , North Ryde, New South Wales 2109, Australia; 16 University Avenue , , North Ryde, New South Wales 2109, Australia School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA; College of Food and Bioengineering, South China University of Technology, Guangzhou 510640, China Department of Orthopedics, The Second Affiliated Hospital of Bengbu Medical College, Bengbu Department of Epidemiology, School of Public Health, Air Force Medical University, Xi'an 710032, Shaanxi, China. Department of Neurology, Children's Hospital of Jiangxi Province, Nanchang 330006, China. chen19831102@sina.com. School of Chemistry and Chemical Engineering, Institute of Theoretical and Computational Chemistry, Lab of Mesoscopic Chemistry, Nanjing University, Nanjing, 210093, P. R. China College of Chemistry, Fuzhou University, Fuzhou, 350116, PR China The Third Xiangya Hospital, Changsha 410013, Hunan Province, China; Department of Cell Biology, Institute of Basic Medical Sciences, Academy of Military Medical Sciences, Beijing 100850, China; Affiliated Hospital of Academy of Military Medical Sciences,Beijing 100071,China. Department of Orthopaedic, Jiangbei Branch of Southwest Hospital 958th Hospital of the PLA Army, No. 29 Jianxin East Road, Jiangbei District Chongqing 400000 China; Department of Orthopaedic, Southwest Hospital The First Affiliated Hospital of Army Medical University No. 30 Gaotanyan Zhengjie, Shapingba District Chongqing 400038 China School of Pharmacy; Chengdu Medical College; Chengdu; P. R. China School of Life Science and Engineering, Southwest Jiaotong University, Chengdu, China; Department of Laboratory Medicine, the First Affiliated Hospital, Chongqing Medical University, Chongqing, P.R. China Department of Radiation Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China Institute of Physics, Chinese Academy of Sciences and Beijing Key Laboratory for Nanomaterials and Nanodevices, P.O. Box 603, Beijing 100190, China School of Public Health the Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou China Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Photochemistry, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China Department of Medicine, University of Wisconsin (H.C., D.F.M.), Madison, Wisconsin 53706; Institut National de la Santé et de la Recherche Médicale U-244, Laboratoire de Biochimie des Régulations Cellulaires Endocrines, Département de Biologie Moléculaire et Structurale, CEA/Grenoble (M.D., A.M.C., B.L., M.K., S.A.-G., E.M.C., J.-J.F.), F-38054 Grenoble Cedex 9, France Department of Clinical Laboratory, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China Department of Intensive Care Medicine, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China School of Biomedical Engineering, Center for Infectious Diseases, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China. Department of Cell Biology and Medical Genetics, Zhengzhou University, Zhengzhou, Henan, 450052 P. R. China. Department of Microbiology and Immunology, Georgetown University School of Medicine, Washington, District of Columbia, USA; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA MOE Key Laboratory of Environmental Remediation & Ecosystem Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China Department of Radiology, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Hubei, PR China Department of Cardiology Renmin Hospital of Wuhan University Wuhan China Department of Epidemiology and Health Statistics School of Public Health Shandong University Jinan China Beijing National Laboratory for Molecular Sciences (BNLMS); CAS Key Laboratory of Photochemistry; Institute of Chemistry; Chinese Academy of Sciences; Beijing School of Public Health, Zhejiang University School of Medicine, Hangzhou, China; Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, Jiangsu 215123, P.R. China State Key Laboratory of Analytical Chemistry for Life Science; Jiangsu Key Laboratory of Advanced Organic Materials; School of Chemistry and Chemical Engineering; Nanjing University; Nanjing 210023 Department of Cardiovascular Medicine The Third Affiliated Hospital of Nanchang University Nanchang of Jiangxi China Department of Orthopaedics, Zhongda Hospital, Southeast University, Nanjing, Jiangsu, China. Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA Department of Laboratory Medicine, Jiangxi Provincial People's Hospital The First Affiliated Hospital of Nanchang Medical College Nanchang China Department of Resources and Environment, Fujian Forestry College, Nanping 353001. zjchchenh@163.com Department of Gastroenterology Second Xiangya Hospital of Central South University Changsha China Guangxi Key Laboratory of AIDS Prevention and Treatment & Guangxi Universities Key Laboratory of Prevention and Control of Highly Prevalent Disease, School of Public Health, Guangxi Medical University, Nanning, Guangxi, People’s Republic of China Division of Nutritional Sciences, Cornell University, Ithaca, NY 14853, U.S.A. School of Public Health, Zhejiang University School of Medicine, Hangzhou 310051, China Beijing National Laboratory for Molecular Sciences (BNLMS), CAS Key Laboratory of Photochemistry, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, People’s Republic of China Department of Nephrology, the First Affiliated Hospital of Fujian Medical University, Fuzhou, P.R. China; Institute of Oceanography, National Taiwan University, Taipei 10617, Taiwan. Department of Internet Management and Quality Control, Beijing Emergency Medical Center Department of Ophthalmology, Affiliated Hospital, Nantong University, Nantong, Jiangsu, China, School of Biomedical Engineering, Capital Medical University, Beijing, P.R. China University of Technology Sydney; School of Life Sciences; PO Box 123, Broadway Sydney New South Wales (NSW) Australia 2007 The Fifth People's Hospital of Suzhou Suzhou China; Key Laboratory of TB Prevention and Cure of Suzhou Suzhou China Department of Pediatric Neurology Chengdu Women’s and Children’s Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, Guangdong, China State Key Laboratory of Superlattices and Microstructures, Institute of Semiconductors, Chinese Academy of Sciences, Beijing 100083, China Department of Sports Medicine, National Research Institute of Sports Science, Beijing, China School of Chemistry and Chemical Engineering, Nanjing National Laboratory of Microstructures, Nanjing University, 22 Hankou Road, Nanjing 210093, P. R. China, and State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai, P. R. China College of Food Science and Engineering Ocean University of China Qingdao P. R. China Department of Oral Medicine, Affiliated Hospital of Stomatology, Medical College, Zhejiang University, Hangzhou 310006, Zhejiang Province, China. Huic66@hotmail.com Department of Cardiology, Cardiovascular Centre, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China Institute of Chemistry and the Lise-Meitner-Minerva Center for Computational Quantum Chemistry, The Hebrew University of Jerusalem, 91904 Jerusalem, Israel Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy Xuzhou Medical College Xuzhou Jiangsu 221004 China; Xuzhou Institute for Drug Control Xuzhou Jiangsu 221002 China School of Environmental & Safety Engineering, Changzhou University, Changzhou 213164, China College of Food Science and Engineering; Ocean University of China; Qingdao 266003; China Centre de Recherche des Cordeliers, Équipe labellisée par la Ligue contre le cancer, Inserm U1138, Université Paris Cité, Sorbonne Université, Paris, France; Metabolomics and Cell Biology Platforms, Gustave Roussy Institut, Villejuif, France; Faculté de Médecine, Université de Paris Saclay, Kremlin Bicêtre, Paris, France State Key Laboratory of Structural Chemistry; Fujian Institute of Research on the Structure of Matter; The Chinese Academy of Sciences; Fuzhou, China; University of Chinese Academy of Sciences Department of Organic Chemistry and the Lise Meitner-Minerva Center for Computational Quantum Chemistry, The Hebrew University of Jerusalem, Givat Ram Campus, 91904 Jerusalem, Israel, and Institut für Organische Chemie der RWTH Aachen, Landoltweg 1, D-52074 Aachen, Germany Department of Cardiology, Cardiovascular Center, Beijing Friendship Hospital, Capital Medical University Department of Pathology, Division of Pathology and Laboratory Medicine The University of Texas MD Anderson Cancer Center Houston Texas Key Laboratory of Hainan Trauma and Disaster Rescue, The First Affiliated Hospital of Hainan Medical University, Hainan Medical University, Haikou 571199, China; Engineering Research Center for Hainan Bio-Smart Materials and Bio-Medical Devices, Key Laboratory of Emergency and Trauma, Ministry of Education, Key Laboratory of Hainan Functional Materials and Molecular Imaging, College of Pharmacy, College of Emergency and Trauma, Hainan Medical University, Haikou 571199, China College of Food Science and Engineering Ocean University of China Qingdao 266003 China Department of Spinal Surgery, the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, China. Laboratory of Anaesthesiology & Critical Care Medicine; West China Brain Research Center; West China Hospital; Sichuan University; Chengdu Geriatric department, The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Sichuan, China Department of Urology, Guangdong Provincial Work Injury Rehabilitation Hospital, Guangzhou, People’s Republic of China; Department of Urology, Qingyan City People's Hospital, Guangdong, People’s Republic of China Department of Pathology Jinan University School of Medicine Guangzhou China Hemodialysis Center, Department of Nephrology West China Hospital, Sichuan University Chengdu China; West China School of Nursing Sichuan University Chengdu China Department of Pathology, Central Laboratory of The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510150, P.R. China School of Biomedical Engineering, Capital Medical University, Beijing 100069, P.R. China Department of Pharmacology, and CRC for Chronic Inflammatory Diseases; Department of Medicine, The University of Melbourne, Royal Melbourne Hospital, Victoria; and Department of Physiology and Pharmacology, School of Medical Sciences, University of New South Wales, Sydney, Australia Key Laboratory of Biofuels, Shandong Provincial Key Laboratory of Synthetic Biology, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao, Shandong, China Department of Microbiology and Immunology, Georgetown University Medical Center, Washington, District of Columbia. Email: huic66@hotmail.com. Department of Radiology; Second Hospital of Hebei Medical University; Shijiazhuang Hebei 050000 People's Republic of China Department of Neurosurgery Children's Hospital of Chongqing Medical University Chongqing People's Republic of China Endocrine Department, Subei People's Hospital of Jiangsu Province, Nantong West Road NO 98, Yangzhou, Jiangsu 225001, China. Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, School of Medicine, Zhejiang University, Key Laboratory of Combined Multi‑Organ Transplantation, Ministry of Public Health Key Laboratory of Organ Transplantation, Collaborative Innovation Center for Diagnosis Treatment of Infectious Diseases, Hangzhou, Zhejiang 310003, P.R. China Department of Gastroenterology, Affiliated Hospital of Jiangsu University, Jiangsu University, Zhenjiang, China Chinese Academy of Inspection and Quarantine, Beijing 100176, People’s Republic of China College of Life Science and Technology, Harbin Normal University, Harbin 150025, PR China Department of Ophthalmology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA. Department of Orthopedics, Orthopedic Institute, Northern Jiangsu People’s Hospital Affiliated to Yangzhou University, Yangzhou, Jiangsu, China Ningxia Center for Disease Control and Prevention, Yinchuan, People's Republic of China Department of Radiology, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, Hubei Province, China Department of Geriatrics Hospital of Traditional Chinese Medicine Affiliated to Southwest Medical University No.182, Chunhui Road, Longmatan District Luzhou Sichuan 646000 China Department of Cardiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China. School of Medical and Molecular Biosciences Faculty of Science Centre for Health Technology University of Technology Sydney NSW Australia; Department of Pharmacology School of Medical Sciences University of New South Wales Sydney NSW Australia Clinical and Integrative Diabetes and Obesity Integrated Review Group, Center for Scientific Review, National Institutes of Health, Bethesda, Maryland State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Centre for Infectious Diseases, Collaborative Innovation Centre for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, 79 Qingchun Rd., Hangzhou City 310003, China State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, NO.1 Xian Nong Tan Street, Beijing 100050, People’s Republic of China First Affiliated Hospital of Xi’an Medical University Department of Pulmonary and Critical Care Medicine, , Xi’an, Shaanxi 710077 , China Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, PR China;; Cardiovascular Research Institute, Wuhan University, Wuhan, PR China;; Hubei Key Laboratory of Cardiology, Wuhan, PR China Economical Forest Cultivation and Utilization of 2011 Collaborative Innovation Center in Hunan Province, Hunan Key Laboratory of Biomedical Nanomaterials and Devices, Hunan University of Technology, Zhuzhou 412007, China College of Environmental Science and Engineering, Hebei University of Science and Technology, Shijiazhuang 050018, China. Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Photochemistry, State Key Laboratory for Structural Chemistry of Unstable and Stable Species, Institute of Chemistry, Chinese Academy of Sciences, 2 Bei Yi Jie, Zhong Guan Cun, Beijing 100190, People’s Republic of China State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing, China; Department of Orthopaedics Zhongda Hospital Southeast University Nanjing China Central Laboratory, The Affiliated Infectious Hospital of Soochow University, Suzhou, China.; Key Laboratory of Infection and Immunity of Suzhou City, Suzhou, China. Lawrence Livermore National Laboratory , Livermore, California 94550, USA National Research Center for Edible Fungi Biotechnology and Engineering, Key Laboratory of Applied Mycological Resources and Utilization, Ministry of Agriculture, Shanghai Key Laboratory of Agricultural Genetics and Breeding, Institute of Edible Fungi, Shanghai Academy of Agricultural Sciences, No. 1000, Jinqi Road, Fengxian District, Shanghai 201403, China Clinical Epidemiology Unit Qilu Hospital of Shandong University Jinan China; Clinical Research Center of Shandong University Qilu HospitalCheeloo College of MedicineShandong University Jinan China Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China Surrozen Operating, Inc., South San Francisco, CA, USA School of Statistics, Renmin University of China, Beijing, China College of Science and Technology, Ningbo University, Ningbo 315211, China College of Science and Technology Ningbo University Ningbo China Department of Orthopaedics, Zhongda Hospital, School of Medicine, Southeast University, No. 87 Ding Jia Qiao, Nanjing, Jiangsu 210009, China Shenzhen Grubbs Institute and Department of Chemistry Southern University of Science and Technology Shenzhen 518055 China Department of Internal Medicine, Fujian Provincial Cardiovascular Disease Institute, Provincial Clinical College of Fujian Medical University, Fuzhou, Fujian 350001, China; Clinical Discipline of Chinese and Western Integrative Medicine, Fujian University on Traditional Chinese Medicine, Fuzhou 350108, China Department of Ophthalmology, Northwestern University, Evanston, Illinois State Key Laboratory for Agro‐Biotechnology and Department of Plant Pathology China Agricultural University Beijing 100193 China Department of Neurosurgery, Second Affiliated Hospital, and Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hubei, China Department of Lung Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China (mainland) National Research Center for Edible Fungi Biotechnology and Engineering, Key Laboratory of Applied Mycological Resources and Utilization, Ministry of Agriculture, Shanghai Key Laboratory of Agricultural Genetics and Breeding, Institute of Edible Fungi, Shanghai Academy of Agricultural Sciences, Shanghai 201403, China; College of Food Sciences and Technology, Shanghai Ocean University, Shanghai 200090, China Department of Pathology, Nanjing Jinling Hospital, Nanjing University School of Medicine, Jiangsu 210000, People’s Republic of China Temasek Laboratories@NTU; Nanyang Technological University; Research Techno Plaza; 50 Nanyang Drive; Singapore Department of Burn and Plastic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China Beijing National Laboratory for Molecular Science, Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China State Key Laboratory of Superlattices and Microstructures; Institute of Semiconductors; Chinese Academy of Science; Beijing 100083, China Department of Oral Radiology Academic Centre for Dentistry Amsterdam (ACTA) University of Amsterdam and VU University Amsterdam Amsterdam The Netherlands; Department of Oral Kinesiology Academic Centre for Dentistry Amsterdam (ACTA) MOVE Research Institute Amsterdam University of Amsterdam and VU University Amsterdam Amsterdam The Netherlands Shanghai Key Laboratory of Biliary Tract Disease Research, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China; State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China; Department of Pharmacology and Chemical Biology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China Geriatrics Digestion Department of Internal Medicine, The First Affiliated Hospital of Guangxi Medical University, 6 Shuangyong Road, Nanning, China Department of Cardiothoracic Surgery, Ningde Municipal Hospital Affiliated to Ningde Normal University, Ningde City, China Cardiovascular Center Capital Medical University, Beijing Friendship Hospital Beijing China School of Medical and Molecular Biosciences, Faculty of Science, Centre for Health Technology, University of Technology, Sydney, New South Wales, Australia Zhejiang University,College of Biomedical Engineering and Instrument Science,Hangzhou,Zhejiang,China,310027 Pharmacy Department of Beijing Chaoyang Hospital, Capital Medical University, No. 8 Gongti South Road, Chaoyang District, Beijing, China MOE Key Laboratory of Wooden Material Science and Application & Beijing Key Laboratory of Wood Science and Engineering, Beijing Forestry University, Beijing 100083, China State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Centre, Sun Yat-sen University, Guangzhou, China Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, MA, USA Guangdong Provincial Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, 132 East Outer Ring Road, Guangzhou 511400, China Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao tong University, School of Medicine, Shanghai, China.; Department of Laser Center, Shanghai Ninth People's Hospital, Shanghai Jiao tong University, School of Medicine, Shanghai, China. Department of Orthopedics, BenQ Medical Center The Affiliated BenQ Hospital of Nanjing Medical University Nanjing China Key Laboratory for Analytical Science of Food Safety and Biology, MOE, College of Chemistry, Fuzhou University, Fuzhou, Fujian 350116, P. R. China State Key Laboratory of Molecular Biology Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences Shanghai 200031 China College of Life Sciences East China Normal University Shanghai China Department of Psychology and Behavioral Sciences, Zhejiang University, Hangzhou 310058, China Department of Plastic and Reconstructive Surgery Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai China Geriatrics Digestion Department of Internal Medicine, The First Affiliated Hospital of Guangxi Medical University, Nanning, China. Key Laboratory of Artificial Micro/Nano-Structures, Ministry of Education, School of Physics and Technology, Wuhan University, Wuhan 430072, China Department of Materials Science and Engineering Peking University Beijing 100871 China Reproductive and Genetic Hospital of CITIC‐Xiangya Changsha China; Clinical Research Center For Reproduction and Genetics in Hunan Province Changsha China Department of Critical Care Medicine, The Second Hospital of Hebei Medical University, 215 Heping West Road, Shijiazhuang, Hebei 050000, China College of Energy Storage Technology, Shandong University of Science and Technology, Qingdao 266590, P. R. China Facebook Reality Labs Research, Menlo Park, California Department of Orthopedics, Clinical Medical College of Yangzhou University, Subei People's Hospital of Jiangsu Province, Yangzhou, China. State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry, Jilin University, Changchun 130012, P. R. China Department of Plastic and Reconstructive Surgery Shanghai Ninth People's Hospital School of Medicine Shanghai Jiao Tong University Shanghai China Department of Liver Diseases and Digestive Interventional Radiology, Xijing Hospital of Digestive Diseases, Xijing Hospital, Fourth Military Medical University, No. 15 West Changle Road, Xi’an 710032, China State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing 100850, China Department of Nutrition and Food Safety, School of Public Health, Fujian Medical University, FuZhou 350122, P.R. China Department of Epidemiology and Statistics, School of Public Health, Central South University, Changsha 410078,China. School of Geographical Sciences, Fujian Normal University, Fuzhou 350007, China. Fujian Provincial Key Laboratory of Plant Ecophysiology, Fujian Normal University, Fuzhou 350007, China. Beijing National Laboratory for Molecular Sciences (BNLMS) Key Laboratory of Photochemistry Institute of Chemistry Chinese Academy of Sciences Beijing 100190 China Shanxi Key Laboratory of Gas Energy Efficient and Clean Utilization, Taiyuan University of Technology, Taiyuan 030024, China; College of Chemistry and Chemical Engineering, Taiyuan University of Technology, Taiyuan 030024, China Department of Ultrasound, the Third Affiliated Hospital of Soochow University, Changzhou, China Department of Radiation Oncology, Nanjing Jiangning Hospital, Nanjing Medical University, Nanjing, P.R. China State Key Laboratory of Ophthalmology Zhongshan Ophthalmic Center Sun Yat‐sen University Guangzhou Guangdong China Department of Cardiology, Beijing Friendship Hospital of Capital Medical University, Beijing 100050, China. Centre de Recherche des Cordeliers, Equipe labellisée par la Ligue contre le cancer, Inserm U1138, Université Paris Cité, Sorbonne Université, Institut Universitaire de France, Paris, France. Metabolomics and Cell Biology Platforms, UMS AMMICa, Gustave Roussy, Villejuif, France. Faculté de Médecine, Université de Paris Saclay, Kremlin Bicêtre, France. Department of Laboratory Medicine; The First Affiliated Hospital of Chongqing Medical University; Chongqing; P. R. China State Key Laboratory of Microbial Technology Shandong University No. 72 Binhai Road Qingdao Shandong 266237 P. R. China Department of Radiology, Beijing Ditan Hospital, Capital Medical University, China School of Medical and Molecular Biosciences, University of Technology Sydney, Sydney, NSW, 2007, Australia. Department of Radiology Southwest Hospital, Army Medical University (Third Military Medical University) Chongqing P.R. China Centre National de la Recherche Scientifique, Institut de Combustion Aérothermique Réactivité et Environnement ICARE/OSUC, CNRS 1C, Avenue de la Recherche Scientifique, 45071 Orléans cedex 02, France Department of Chemistry University of Utah 315 S 1400 E Salt Lake City UT 84112 USA Third Institute of Oceanography Ministry of Natural Resource Xiamen China; Engineering Research Center of Marine Biological Resource Comprehensive Utilization Ministry of Natural Resource Xiamen China; Fujian Collaborative Innovation Center for Exploitation and Utilization of Marine Biological Xiamen China Spine Surgery Department, Affiliated Drum Tower Hospital, Nanjing University Medical School, Nanjing, China. School of Life Sciences, Faculty of Science, University of Technology Sydney, NSW Australia. Pharmaceutical Analysis, Faculty of Pharmaceutical Sciences, KU Leuven, Leuven, Belgium, College of Life Science, Northwest A&F University, Yangling, Shaanxi 712100, China.; College of Forestry, Northwest A&F University, Yangling, Shaanxi 712100, China.; College of Food Science and Engineering, Northwest A&F University, Yangling, Shaanxi 712100, China. School of Biotechnology, East China University of Science and Technology, Shanghai 200237, China. Co-construction Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases by Henan & Education Ministry of P. R. China, Henan University of Chinese Medicine, Zhengzhou 450046, P. R. China; School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, P. R. China Biological Systems Engineering Department Virginia Tech Blacksburg VA USA College of Life Science, Sichuan Agricultural University, Xinkang Road 46, Ya’an, Sichuan 625014, People’s Republic of China From the Departments of Internal Medicine (R.A.M., C.N.B., C.A.P., C.A.H., A.G.) and Community Health Sciences (R.A.M., C.A.P., R.F., A.G.), and IBD Clinical and Research Centre (C.N.B.), University of Manitoba, Winnipeg; and Manitoba Centre for Health Policy (H.C., R.F., A.G.), Winnipeg, Canada. Department of Gastroenterology, Changhai Hospital The Second Military Medical University Shanghai China Department of Plastic and Reconstructive Surgery, Shanghai 9th People’s Hospital, Shanghai Jiao Tong University, Shanghai, China Department of Cardiology, Cardiovascular Center, Beijing Friendship Hospital, Capital Medical University, Beijing, China Institute of Chemistry and The Lise Meitner-Minerva Center for Computational Quantum Chemistry, The Hebrew University of Jerusalem, Givat Ram Campus, 91904 Jerusalem, Israel Department of Neurosurgery; Sichuan Friendship Hospital; Chengdu 610066; China Department of Otorhinolaryngology, Chengdu Integrated TCM and Western Medicine Hospital, Chengdu, China Chimie ParisTech PSL Université Paris CNRS, Institut de Recherche de Chimie Paris UMR8247, 11 rue Pierre et Marie Curie Paris 75005 France Cardiovascular Center, Beijing Friendship Hospital, Capital Medical University, China Key Laboratory for Robot and Intelligent Technology of Shandong Province College of Electrical Engineering and Automation Shandong University of Science and Technology Qingdao 266590 P.R. China Engineering Research Centre of Organosilicon Compounds and Materials of Ministry of Education, College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, China Research Center for Analytical Sciences, College of Chemistry Nankai University Tianjin P. R. China Southwest Jiaotong University Department of Emergency Medicine, Traditional Chinese Medicine Hospital of Kunshan, 215300 Kunshan, China Equipe labellisée par la Ligue contre le cancer, Université de Paris, Sorbonne Université, INSERM UMR1138, Centre de Recherche des Cordeliers, Paris, France; Metabolomics and Cell Biology Platforms, Gustave Roussy, Villejuif, France; Université Paris Sud, Paris Saclay, Faculty of Medicine, Kremlin Bicêtre, France. College of Chemistry; Fuzhou University; Fuzhou; PR China Departments of Geriatrics, Guangzhou Geriatric Hospital, 510550 Guangzhou, China; Department of Geriatrics, Home for the Aged Guangzhou, 510550 Guangzhou, China Department of Ophthalmology, OUHSC, Oklahoma City, OK 73104, USA. Fourth Military Medical University Xi'an China The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, Zhejiang, China Department of Neurology, Jiangxi Provincial Children’s Hospital, Nanchang, China. Department of Pathology, Jinling Hospital, Affiliated Hospital of Medical School Nanjing University Nanjing China Department of Nephrology, Wenzhou Central Hospital, Wenzhou, China Department of Gastroenterology, Jiangsu Taizhou People’s Hospital, Taizhou, Jiangsu, China School of Materials and Energy, University of Electronic Science and Technology of China, Chengdu 610054, China BGI-Shenzhen; Shenzhen China Hunan Key Laboratory of Biomedical Nanomaterials and Devices Hunan University of Technology Zhuzhou China Department of Nephrology, The First Affiliated Hospital of Fujian Medical University Fuzhou, Fujian, China. Department of Obstetrics and Gynecology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, Guangdong, China Cardiology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, and Department of Pharmacology, The University of Texas Health Science Center, San Antonio, Texas 78284 Beijing National Laboratory of Photochemistry, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China Department of Chemistry and Shenzhen Grubbs Institute, Southern University of Science and Technology, Shenzhen 518055, P. R. China Department of Gynecology and Obstetrics Sun Yat‐sen Memorial Hospital Sun Yat‐sen University Guangzhou China College of Environmental Science and Engineering, Hebei University of Science and Technology, Shijiazhuang 050000, China. Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (MOE), School of Pharmaceutical Sciences, Shandong University, Jinan, Shandong 250012, China; Laboratory of Anaesthesiology and Critical Care Medicine, Translational Neuroscience Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China School of Automotive Studies, Tongji University, Shanghai 201804, China Emergency Medicine; Emergency Medicine Department of Psychiatry, Second Xiangya Hospital, Central South University, Changsha 410011. chenh0618@163.com. National Clinical Research Center for Mental Disorders, Second Xiangya Hospital, Changsha 410011. chenh0618@163.com. Shanghai Key Laboratory of regulatory Biology Institute of Biomedical Sciences School of Life Sciences East China Normal University Shanghai China The State Key Laboratory of Refractories and Metallurgy, Wuhan University of Science & Technology, Wuhan, 430081, China Department of Pediatric Dentistry School of Stomatology Ninth People's Hospital Medical College Shanghai Jiaotong University Shanghai China From the Departments of Ophthalmology, Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, School of Medicine Shanghai Jiao Tong University Shanghai China The Key Laboratory for Drug Target Researches and Pharmacodynamic Evaluation of Hubei Province Wuhan, China. Hubei Provincial Centre for Disease Control and Prevention Wuhan China Department of Chemistry and Shenzhen Grubbs Institute, Southern University of Science and Technology, Shenzhen 518055, China Department of Pediatric Neurology, Chengdu Women and Children's Central Hospital, Chengdu 610091, China. Department of Obstetrics and Gynecology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, People's Republic of China Beijing National Laboratory for Molecular Science, Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, P. R. China Department of Plastic and Reconstructive Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China Department of Cardiology Beijing Friendship Hospital, Capital Medical University Beijing China Department of Histology and Embryology, Jilin Medical College, Jilin 132013, China. Department of Gastroenterology Gongli Hospital, The Second Military Medical University Shanghai China; Department of Gastroenterology Changhai Hospital, The Second Military Medical University Shanghai China Institute of Environment Pollution Control and Treatment; Department of Environmental Engineering; Zhejiang University; Hangzhou 310058; China The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science & Technology Wuhan 430081 P. R. China Capital Medical University, Beijing Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Department of Ophthalmology, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu 610072, Sichuan Province, China ; Institute of Laboratory Animals, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu, Sichuan 610072, China, Luzhou 646000, Sichuan Province, China. State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, 122 Luoshi Road, Wuhan 430070, People’s Republic of China School of Mechanical Engineering, Shanghai Dianji University, Shanghai, People’s Republic of China Beijing Key Laboratory of Environmental and Viral Oncology, College of Life Science and Bio-engineering, Beijing University of Technology, Beijing 100124, P. R. China Department of Pathology, Third Affiliated Hospital, Guangzhou Medical University, Guangzhou 510150, China Department of Pediatric Dentistry, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine; Shanghai Key Laboratory of Stomatology. Shanghai 200011, China. E-mail:falls_chen@189.cn. Department of Intensive Care Unit, The Second Hospital of Hebei Medical University, Hebei Province, China Lawrence Livermore National Laboratory 1 , Livermore, California 94550, USA Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, 430060 Hubei, China; Cardiovascular Research Institute, Wuhan University, Wuhan, 430060 Hubei, China; Hubei Key Laboratory of Cardiology, Wuhan, 430060 Hubei, China Heart Center of Henan Provincial People’s Hospital, Central China Fuwai Hospital, Central China Fuwai Hospital of Zhengzhou University, Zhengzhou, P. R. China Department of Neurosurgery, 2nd Affiliated Hospital, Harbin Medical University Department of Pathology, Nanjing General Hospital, Jiangsu 210002, People’s Republic of China College of Life Science Yangtze University Jingzhou China Department of Obstetrics and Gynecology University Hospital Castelló Castelló de la Plana Spain Advanced Photonics Center, Southeast University, Nanjing 210096, China Department of Gastroenterology, Hunan Provincial People’s Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha, Hunan Province, China Clinical Laboratory, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, P.R. China Biomedical Informatics Laboratory, Capital Medical University, Beijing, China. Xuzhou Institute for Food and Drug Control, Xuzhou 221000, China Beijing National Laboratory for Molecular Sciences Key Laboratory of Organic Solids Institute of Chemistry Chinese Academy of Sciences Beijing 100190 P. R. China Medical Division, Zhongda Hospital, Southeast University, Nanjing 210009, China Data Analyst, Manitoba Centre for Health Policy, Department of Community Health Sciences, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba 1Department of Pathology, University of Texas MD Anderson Cancer Center, Houston, Texas. Department of Liver Diseases and Digestive Interventional Radiology Xijing Hospital of Digestive Diseases School of Life Sciences Faculty of Science University of Technology Sydney Sydney NSW 2007 Australia Department of Cardiology, Renmin Hospital of Wuhan University, Cardiovascular Research Institute, Wuhan University, Hubei Key Laboratory of Cardiology, Wuhan, Hubei 430060, China State Key Laboratory of Inorganic Synthesis and Preparative Chemistry International Joint Research Laboratory of Nano-Micro Architecture Chemistry College of Chemistry Jilin University Changchun 130012 P.R. China; Department of Materials Science and Engineering Jilin University Changchun 130022 P.R. China Department of Plastic and Reconstructive Surgery Shanghai Ninth People's Hospital School of Medicine Shanghai Jiaotong University Shanghai China Department of Pharmaceutical Sciences and Computational Chemical Genomics Screening Center, School of Pharmacy; National Center of Excellence for Computational Drug Abuse Research, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, United States College of Engineering, Huazhong Agricultural University, Wuhan 430070, China. College of Water Resources and Architectural Engineering, Northwest A&F University, Yangling 712100, Shaanxi, China. School of Laboratory Medicine and Life Science, Wenzhou Medical University, Wenzhou 325035, Zhejiang, China. NHC Key Laboratory of Pulmonary Immunological Diseases, Guizhou Provincial People’s Hospital, Guiyang, China School of the Environment and Safety; Jiangsu University; 212013 Zhenjiang; China Centre for Health Technologies & Molecular Biosciences, School of Life Sciences, University of Technology Sydney, Sydney, New South Wales, Australia; Key Laboratory of Algal Biology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China Department of Anesthesiology and Perioperative Medicine, Shanghai Fourth People's Hospital Affiliated to Tongji University School of Medicine No. 1279, Sanmen Road, Shanghai 200434, China. Geriatric Medicine Department Northern Jiangsu People's Hospital and Clinical Medical College of Yangzhou University Yangzhou China Department of Pulmonary and Critical Care Medicine, The Affiliated Hospital of Medical School, Ningbo University, Ningbo, Zhejiang Province, China Department of Dermatology and Venereology Xuanwu Hospital Capital Medical University Xicheng District, Beijing China Epithelial Cell Biology Research Center (H.C., J.H.G., Y.C.L., M.K.Y., L.L.T., K.L.F., X.M.L., X.H.Z., Y.W.C., H.C.C.), School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong Department of Cardiovascular Medicine The Third Affiliated Hospital of Nanchang University Nanchang China Key Laboratory of Cell Engineering of Guizhou Province and Regenerative Medicine Centre, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China College of Life Science, Sichuan Agriculture University, Ya’an 625014, Sichuan, People’s Republic of China State Key Laboratory of Superlattice and Microstructures, Institute of Semiconductors, Chinese Academy of Sciences, No. A 35, Qinghua East Road, Haidian District, Beijing 100083, China Institute of Environmental Science, Zhejiang University, Hangzhou 310058, China Key Laboratory of Thermo-Fluid Science and Engineering of MOE, School of Energy and Power Engineering, Xi’an Jiaotong University , Xi’an, Shaanxi 710049, People’s Republic of China Department of Radiology, Neuroradiology Section, Stanford, CA, USA; Encephalopathy Center, Beijing Chaoyang Integrative Medicine Emergency Medical Center, Beijing, China Department of Pharmacy Guangdong Provincial People's Hospital Guangdong Academy of Medical Sciences Guangzhou Guangdong P. R. China; Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention Guangdong Provincial People's Hospital Guangdong Academy of Medical Sciences Guangdong Cardiovascular Institute Guangzhou Guangdong P. R. China; School of Medicine South China University of Technology Guangzhou Guangdong P. R. China Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science Soochow University Suzhou 215123 People's Republic of China State Key Laboratory of Chemical Oncogenomics, Guangdong Provincial Key Laboratory of Chemical Biology, Tsinghua Shenzhen International Graduate School, Shenzhen 518055, P. R. China International Phosphorus Laboratory, College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou 450001, P. R. China, Institut des Sciences Chimiques de Rennes, CNRS - Université de Rennes 1, Campus de Beaulieu, 35042 Rennes, France, Laboratoire de Physique des Interfaces et Couches Minces, CNRS UMR 7647, Ecole Polytechnique, 91128 Palaiseau, France, Laboratoire de Chimie des Surfaces et Interfaces, CEA Saclay, IRAMIS, SPCSI, 91191 Gif-sur-Yvette, France, and Nanyang Technological... Jiangsu Zhongneng Polysilicon Technology Development Co., Ltd., Xuzhou 221000, China Department of Gastroenterology; Digestive Endoscopy Center, Changhai Hospital, The Second Military Medical University, Shanghai School of Pharmaceutical Sciences, Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Tsinghua University, Beijing 100084, China; Advanced Innovation Center for Human Brain Protection, Beijing Tiantan Hospital, Capital Medical University, Beijing 100088, China Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology , Wuhan, Hubei, China Department of BME, Capital University of Medical Sciences, Beijing 100054. Clinical Epidemiology Unit, Qilu Hospital Shandong University Jinan China; Department of Epidemiology, School of Public Health Shandong University Jinan China Key Laboratory of Algal Biology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, Hubei, China Department of Cardiology Beijing Friendship Hospital Capital Medical University Beijing China Corresponding author. Lawrence Livermore National Laboratory 1 , Livermore, California 94551, USA Institute of Botany, The Chinese Academy of Sciences, Beijing 100093, P. R. China and Institute of Genetics and Developmental Biology, The Chinese Academy of Sciences, Beijing 100080, P. R. China Department of Endocrinology, the Second Hospital of Lanzhou University, Lanzhou 730030, China. chenhui@lzu.edu.cn. State Key Laboratory for Agro-Biotechnology, and Key Laboratory for Pest Monitoring and Green Management-Ministry of Agriculture and Rural Affairs, Department of Plant Pathology, China Agricultural University, Beijing 100193, China Department of General Surgery Zhejiang Hospital Hangzhou 310013 P. R. China College of Food Science and Nutritional Engineering China Agricultural University Beijing China Department of Physiology and Cell Biology Banting and Best Department of Medical Research and Department of Molecular and Medical Genetics, University of Toronto, Toronto, Ontario M5G 1L6, Canada Department of Hematology, Changhai Hospital, The Second Military Medical University, Shanghai, China Epithelial Cell Biology Research Center School of Biomedical Sciences Faculty of Medicine The Chinese University of Hong Kong Sha Tin NT Hong Kong SAR China From The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation (J.G., B.B.B., X.G., H.Z., L.L., Y.F., S.H., Huafu Chen), School of Medicine (J.G.), and School of Life Science and Technology, Center for Information in Medicine (X.G., H.Z., L.L., Y.F., S.H.), University of Electronic Science and Technology of China, Chengdu; Departments of Radiology (Hui Chen, Y.Z., J.L, J.W., C.L., Huafu Chen) and Laboratory Medicine (L.F.), Southwest Hospital, Department of Medical... From the Department of Interventional Oncology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education) (X.W., J.H., G.C., X.Z., R.Y., H.C., H.X., P.L.), Departments of Radiology (Y.C.), Medical Statistics (X.J.), and GI Oncology (Jian Li, Jie Li, L.S.), and Department of Hepatic, Biliary & Pancreatic Surgery (C.H., B.X.), Peking University Cancer Hospital & Institute, 52 Fucheng Road, Haidian District, Beijing 100142, China; and Department of Mathematics and... School of Nursing, Tianjin Medical University, Tianjin, China; Key Laboratory of Marine Fishery Resources Exploitment & Utilization of Zhejiang Province, Hangzhou 310014, China Guangdong Ocean University, Zhanjiang 524088, China MOE Key Laboratory of Wooden Material Science and Application, Beijing Forestry University, Beijing, 100083, China; Department of Chemistry, Beijing Key Laboratory of Microanalytical Methods and Instrumentation, The Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Tsinghua University, Beijing, 100084, China Department of Biochemistry and Molecular Biology, School of Life Science, Sichuan Agricultural University, 625014, Ya’an, China Department of Plastic and Reconstructive Surgery, Shanghai Jiao Tong University School of Medicine, China MOE Key Laboratory of Environmental Remediation & Ecosystem Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310029, China, College of Biology and Environmental Engineering, Zhejiang Shuren University, Hangzhou 310015, China, and Research Center of Green Chirality, College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310032, China Department of Gastroenterology Digestive Endoscopy Center Changhai Hospital Shanghai China; National Clinical Research Center for Digestive Diseases Shanghai China; Shanghai Institute of Pancreatic Diseases Shanghai China Institute of Chemistry and the Lise Meitner-Minerva Center for Computational Quantum Chemistry, The Hebrew University of Jerusalem, 91904 Jerusalem, Israel Department of Fiber and Polymer Technology, Wallenberg Wood Science Center, KTH Royal Institute of Technology, Teknikringen 56, 100 44 Stockholm, Sweden College of Life Science and Technology, Jinan University, Guangzhou 510632, China Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China. Department of Medicinal Chemistry School of Pharmacy Air Force Medical University Xi'an 710032 P. R. China Laboratory Animal Institute; Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital; Chengdu; P. R. China; School of Medicine Department of Pulmonary and Critical Care Medicine, First Affiliated Hospital of Xi’an Medical University, Xi’an, Shaanxi, China Department of Plastic and Reconstructive Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai , China Department of Radiology, Neuroradiology Division, Quantitative Sciences Unit, Stanford University, Stanford, California, USA. School of Life Sciences, Faculty of Science, University of Technology Sydney, Australia Department of Chemistry, Louisiana State University, Baton Rouge, Louisiana 70803, USA School of Public Health, Zhejiang University School of Medicine, Hangzhou, China Department of Psychology and Behavioral Sciences, Zhejiang University, Hangzhou 310030, China School of Life Sciences, Faculty of Science, University of Technology Sydney, Sydney, New South Wales, Australia Ministry of Education Key Laboratory of Analytical Science for Food Safety and Biology, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, College of Chemistry, Fuzhou University, Fuzhou, Fujian 350116, China Hunan Key Laboratory of Biomedical Nanomaterials and Devices, Hunan University of Technology, Zhuzhou 412007, China School of Life Sciences, Faculty of Science, University of Technology Sydney, Sydney, New South Wales, Australia; University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing 100049, China Geriatrics (H.C.), Clinical Medical College of Yangzhou University, China. Key Lab for Agro-product Processing and Quality Control of Nanchang City, College of Food Science and Engineering, Jiangxi Agricultural University, Nanchang 330045, China College of Pharmacy, Nanjing University of Chinese Medicine, 138 Xianlin Avenue, Nanjing 210023, China Key Laboratory of Physical Electronics and Devices of Ministry of Education & Shaanxi Key Laboratory of Information Photonic Technique, School of Electronic Science and Engineering, Xi’an Jiaotong University, Xi’an 710049, China The Department of Orthopaedic Surgery, Zhongda Hospital, School of MedicineSoutheast UniversityNanjingChina Lawrence Livermore National Laboratory 5 , Livermore, California 94551, USA Nanjing Institute of Environmental Sciences Ministry of Ecology and Environment of the People’s Republic of China Nanjing China College of Chemistry and Molecular Engineering, International Phosphorus Laboratory International Joint Research Laboratory for Functional Organophosphorus Materials of Henan Province Zhengzhou University Zhengzhou 450001 P.R. China; Institute of Chemistry Henan Academy of Sciences Zhengzhou 450002 P.R. China Nanoscience Technology Center, Department of Chemistry, Department of Mechanical, Materials and Aerospace Engineering, University of Central Florida, 12424 Research Parkway Suite 400, Orlando, Florida 32826 Department of Obstetrics and Gynecology, The 909th Hospital, School of Medicine, Xiamen University, 269 Zhanghua Middle Road, Zhangzhou, Fujian, China The Pennsylvania State University Key Laboratory of Environmentally Friendly Chemistry and Application of Ministry of Education, College of Chemistry, Xiangtan University, Xiangtan 411105, China Institute of Physics and School of Physical Sciences and CAS Center for Excellence in Topological Quantum Computation University of Chinese Academy of Sciences Chinese Academy of Sciences Beijing 100190 China School of Nursing, Tianjin Medical University, Tianjin, China Department of Medical Affairs, Zhongda Hospital, Southeast University, Nanjing, Jiangsu Province, China School of Materials Science and Engineering, Yancheng Institute of Technology, Yancheng, Jiangsu 224051, China Laboratory of RNA Biology, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China. Cell‐Gene Therapy Translational Medicine Research Center The Third Affiliated Hospital of Sun Yat‐Sen University Guangzhou China COMOC—Center for Ordered Materials, Organometallics and Catalysis, Department of Chemistry, Ghent University, Krijgslaan 281, building S3, 9000 Ghent, Belgium Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences, School of Life Sciences, East China Normal University, 500 Dongchuan Road, Shanghai, China Jiangsu Alphay Bio-technology Co. Ltd, Nantong 226009, China State Key Laboratory of Chemo/Biosensing and Chemometrics; College of Biology; Key Laboratory for Bio-Nanotechnology and Molecular Engineering of Hunan Province; Hunan University; Changsha 410082 Georgetown University Medical Center, Department of Microbiology and Immunology, Washington, DC, USA Department of Medicinal Chemistry; Key Laboratory of Chemical Biology (MOE); School of Pharmacy; Shandong University; Jinan Key Laboratory for Asymmetric Synthesis & Chirotechnology of Sichuan Province, Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences; University of Chinese Academy of Sciences Department of Pathology The University of Texas MD Anderson Cancer Center Houston Texas USA Department of Neurology, Children’s Hospital of Jiangxi Province, Nanchang, China. School of Ophthalmology and Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, PR China Department of Urology Renmin Hospital of Wuhan University Wuhan P.R. China Department of Environmental Science and Engineering and Institute of Atmospheric Sciences, Fudan University, Shanghai 200433, China Protein Chemistry Laboratory, Department of Pathology and Laboratory Medicine, University of Pennsylvania, 401 Stellar-Chance Labs, 422 Curie Boulevard, 19104, Philadelphia, PA, USA Advanced Photonics Center, Southeast University, 2# Sipai Lou, Nanjing 210096, Jiangsu China State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing, 100850, China Division of Restorative Dental Sciences Faculty of Dentistry The University of Hong Kong Hong Kong China Department of Chemistry Capital Normal University Beijing 100048 P.R. China The Key Laboratory of Food Colloids and Biotechnology, Ministry of Education, School of Chemical and Material Engineering Jiangnan University 214122 Wuxi China Department of the Key Specialty of Spleen and Stomach, The Second People’s Hospital Affiliated to Fujian University of Traditional Chinese Medicine, Fuzhou, China State Key Laboratory of Bioelectronics, Southeast University, Nanjing 210096, China Department of Clinical Laboratory, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China College of Life Sciences, Sichuan Normal University, Chengdu, China From the Department of Otolaryngology-Head and Neck Surgery, Affiliated with the Eye and ENT Hospital of Fudan University, Shanghai, China Department of Oncology, Affiliated Hospital of Southwest Medical University, Luzhou, China State Key Laboratory of Electronic Thin Film and Integrated Devices University of Electronic Science and Technology of China Chengdu 610054 P. R. China; State Key Laboratory of Marine Resource Utilization in South China Sea Hainan University Haikou 570228 P. R. China; Department of Materials Science and Engineering College of Engineering Peking University Beijing 100871 P. R. China College of Life and Basic Sciences Sichuan Agricultural University Ya'an 625014 China hanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences, School of Life Sciences, East China Normal University, Shanghai 200241, P.R. China Department of Respiratory Medicine, Jinhua Municipal Central Hospital, Jinhua Hospital of Zhejiang University Wadsworth Center, New York State Department of Health, Empire State Plaza, Albany, NY 12201, U.S.A. Departments of Pharmacology (H.C., M.J.M.), School of Medical Sciences, University of New South Wales, New South Wales 2052, Australia Guangdong Work Injury Rehabilitation Hospital Guangzhou Guangdong China National Clinical Research Center for Eye Diseases Shanghai General Hospital Shanghai Jiao Tong University School of Medicine Shanghai China; Shanghai Key Laboratory of Fundus Diseases Shanghai China; Shanghai Engineering Center for Visual Science and Photomedicine Shanghai China; Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases Shanghai China; School of Medicine University of Electronic Science and Technology of China Chengdu Sichuan Province China College of Animal Science and Veterinary Medicine Jilin University 5333 Xi'an Road Changchun Jilin 130062 China Technology Innovation Center for Exploitation of Marine Biological Resources, Third Institute of Oceanography, Ministry of Natural Resources, Xiamen361005, China; Xiamen Ocean Vocational College, Xiamen361022, China State Key Laboratory of Conservation and Utilization of Subtropical Agro-Bioresources, Guangdong Laboratory for Lingnan Modern Agriculture, Guangdong Key Laboratory for Innovative Development and Utilization of Forest Plant Germplasm, College of Forestry and Landscape Architecture, South China Agricultural University, Guangzhou, China College of Chemistry and Molecular Sciences Hubei Key Laboratory of Electrochemical Power Sources Wuhan University 430072 Wuhan China College of Electrical Engineering and Automation Shandong University of Science and Technology Qingdao 266510 China College of Food Science and Technology Zhejiang University of Technology Hangzhou China; Key Laboratory of Marine Biological Resources Innovation and Development of Zhejiang Province, Zhejiang University of Technology Hangzhou China; Collaborative Innovation Center of Seafood Deep Processing Dalian Polytechnic University Dalian China Department of Chemistry and Institutes of Biomedical Sciences, Fudan University, Shanghai 200433, P. R. China Center for Ordered Materials, Organometallics and Catalysis (COMOC), Department of Chemistry, Ghent University, 281 Krijgslaan (S3), B-9000 Ghent, Belgium Institute of Chemistry and the Lise Meitner-Minerva Center for Computational Quantum Chemistry, Hebrew University of Jerusalem, Givat Ram Campus, 91904 Jerusalem, Israel, State Key Laboratory of Physical Chemistry and Chemical Engineering, Xiamen University, 361005 Xiamen, P. R. China Co-construction Collaborative Innovation Center for Chinese Medicine, Respiratory Diseases by Henan & Education Ministry of P. R. China, Henan University of Chinese Medicine, Zhengzhou, 450046, P. R. China; School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, 450046, P. R. China Department of Gastrointestinal Surgery, The Affiliated First Hospital, Fujian Medical University, Fuzhou, Fujian, China (mainland) State Key Laboratory of Inorganic Synthesis & Preparative Chemistry, College of Chemistry, Jilin University, Changchun 130012, China Department of Gerontology (H.C.), Clinical Medical College of Yangzhou University, China. Department of Obstetrics and Gynecology Sun Yat‐sen Memorial Hospital Guangdong Province China; Key Laboratory of malignant tumor gene regulation and target therapy of Guangdong Higher Education Institutes Sun Yat‐sen Memorial Hospital Guangdong Province China Institute of Chemistry and the Lise-Meitner-Minerva Center for Computational Quantum Chemistry, The Hebrew University of Jerusalem, 91904 Jerusalem, Israel, and Max-Planck-Institut für Kohlenforschung, Kaiser-Wilhelm-Platz 1, D-45470 Mülheim an der Ruhr, Germany State Key Laboratory for Maize Bio‐breeding and Department of Plant Pathology China Agricultural University Beijing China Key Laboratory of Organic Solids Institute of Chemistry Chinese Academy of Sciences Beijing 100190 P. R. China Key Laboratory of Algal Biology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, Hubei, China Department of Pediatrics, Dahua Hospital of Shanghai Xuhui District, Shanghai, China Engineering Research Center of Organosilicon Compounds and Materials of Ministry of Education College of Chemistry and Molecular Sciences Wuhan University Wuhan 430072 China Department of Physiology, School of Basic Medical Science, Central South University, Changsha, Hunan,China Department of Prosthodontics; Ninth People's Hospital; Shanghai Jiao Tong University School of Medicine; Shanghai China College of food science and nutritional engineering, china agriculture university, beijing 100083, china Department of Psychology and Behavioral Sciences, Zhejiang University State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences Fuzhou Fujian 350002 People's Republic of China Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China School of Life Sciences Faculty of Science University of Technology Sydney Sydney NSW Australia Department of Physiology and Pathophysiology, School of Basic Medical Science, Capital Medical University, Beijing 100069, China School of Chemical and Material Engineering Jiangnan University 214122 Wuxi People’s Republic of China The Institute of Chemistry and The Lise Meitner-Minerva Center for Computational Quantum Chemistry, The Hebrew University of Jerusalem, 91904 Jerusalem, Israel, Biometal Science Laboratory, RIKEN, SPring-8 Center, Harima Institute, Hyogo 679-5148, Japan, Department of Biotechnology, Faculty of Engineering, and Biotechnology Research Center, Toyama Prefectural University, Toyama 939-0398, Japan Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai, China Shenzhen Grubbs Institute and Department of Chemistry Southern University of Science and Technology Shenzhen 518055 China; Academy for Advanced Interdisciplinary Studies Southern University of Science and Technology Shenzhen 518055 China Clinical Epidemiology Unit, Qilu Hospital of Shandong University, Jinan, China; Clinical Research Center of Shandong University, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China State Key Laboratory of Conservation and Utilization of Subtropical Agro-Bioresources, Guangdong Laboratory for Lingnan Modern Agriculture, Guangdong Key Laboratory for Innovative Development and Utilization of Forest Plant Germplasm, College of Forestry and Landscape Architecture, South China Agricultural University, Guangzhou, People’s Republic of China Department of Cardiology, Beijing Friendship Hospital, Capital Medical University; Beijing Key Laboratory of Metabolic Disorder Related Cardiovascular Disease, Beijing, China (mainland) School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371, Singapore Geriatric Medicine Northern Jiangsu People’s Hospital Yangzhou China State Key Laboratory of Crop Stress Adaptation and Improvement, School of Life Sciences, Henan University, Kaifeng 475004, China From the Department of Pathology (Ramani, Broaddus, Chen, Rashid, Lazar, Roy-Chowdhuri), The University of Texas MD Anderson Cancer Center, Houston Department of Pharmacology, School of Basic Medical Sciences, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, Shanghai 200032, China From the Third Military Medical University, Chongqing, China (H.C.); Departments of Neurology (H.C., N.L., Y.L., W.Z., G.Z.) and Radiology (B.W.), Military General Hospital of Beijing PLA, Beijing, China; Department of Radiology, Neuroradiology Section, Stanford University, CA (M.W.); GE Healthcare, Beijing, China (Z.S.); Department of Neurology, Southwest Hospital, Third Military Medical University, Chongqing, China (J.H.); and Department of Neurology, Changhai Hospital, Second Military Medical... State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics , Beijing 102206, China; Beijing Institute of Radiation Medicine , Beijing 100850, China Key Laboratory of Artificial Micro- and Nano-structures of Ministry of Education, School of Physics and Technology, Wuhan University, Wuhan 430072, China State Key Laboratory of Chemo/Biosensing and Chemometrics; College of Chemistry and Chemical Engineering; Key Laboratory for Bio-Nanotechnology and Molecular Engineering of Hunan Province; Hunan University; Changsha 410082 Department of General Surgery, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Shanghai University of Traditional Chinese Medicine Shanghai 200437, China. *Department of Integrative Medicine and Neurobiology, School of Basic Medical Sciences, Institute of Acupuncture Research, Institutes of Integrative Medicine, Shanghai Medical College, Fudan University, Shanghai, People’s Republic of China Institute of Chemistry and the Lise Meitner-Minerva Center for Computational Quantum Chemistry, Hebrew University of Jerusalem, Givat Ram Campus, 91904 Jerusalem, Israel Institute of Microbiology, Chinese Academy of Sciences, Beijing 100080, China. Key Laboratory of Hainan Trauma and Disaster Rescue, Laboratory of Neurology, The First Affiliated Hospital of Hainan Medical University, Hainan Medical University, Haikou 571199, China; Key Laboratory of Emergency and Trauma, Ministry of Education, Key Laboratory of Hainan Functional Materials and Molecular Imaging, College of Pharmacy, College of Emergency and Trauma, Hainan Medical University, Haikou 571199, China Department of Psychology and Behavioral Sciences, Zhejiang University, China; chenhui@zju.edu.cn School of Life Sciences; University of Technology Sydney; Sydney Australia Department of Conservative Dentistry and Periodontics, Affiliated Hospital of Stomatology, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China (mainland) Chuanli Ren, Chongxu Han, Daxin Wang, and Hui Chen, Clinical Medical College of Yangzhou University, Yangzhou, China College of Chemistry and Chemical Engineering; Northwest Normal University; Lanzhou; People's Republic of China Department of neurology; Taizhou Municipal Hospital; Taizhou; China Hunan Key Laboratory of Biomedical Nanomaterials and Devices, Hunan University of Technology, Zhuzhou 412007, PR China Advanced Water Management Centre The University of Queensland St Lucia Qld Australia; School of Environmental Science and Engineering Shandong University Qingdao China Department of Dermatology, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology (HUST) Wuhan China Wadsworth Center, New York State Department of Health , 120 New Scotland Ave, Albany, New York 12208 State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing 102206, China. Maerkang Meteorological Bureau, Maerkang 624000, Sichuan, China. Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.; Department of Laser and Aesthetic Medicine, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Department of Civil & Environmental Engineering, Department of Chemical Engineering, College of Engineering, and Department of Mechanical Engineering−Engineering Mechanics, Michigan Technological University, 1400 Townsend Drive, Houghton, Michigan 49931, Department of Civil & Environmental Engineering, Engineering & Public Policy, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213-3890, Department of Chemical and Materials Engineering, Arizona State University, Tempe, Arizona 85287, Nelson... Key Laboratory of Environmental Protection Mining for Minerals Resourses at Universities of Education Department of Xinjiang Uygur Autonomous Region, Xinjiang University, Urumqi 830046, P. R. China; School of Geology & Mining Engineering, Xinjiang University, Urumqi 830046, P. R. China College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China National Clinical Research Center for Digestive Diseases and Xijing Hospital of Digestive Diseases, Air Force Medical University, Xi’an, Shaanxi, China (mainland) Department of Chemistry Fudan University Shanghai 200438 P. R. China Temasek Laboratories, Nanyang Technological University, 50 Nanyang Drive, Singapore 637553 Institute of Physics University of Chinese Academy of Science Chinese Academy of Science Beijing 100190 P. R. China Beijing Maternity Hospital, Capital Medical University, Beijing 100026, China. Transplantation Biology Research Division, State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China; Obstetrics and Gynecology Dept. Of Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, Guangdong Province, China School of Public Health, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China Department of Respiration, Jinhua Central Hospital, Zhejiang University Jinhua Hospital, Jinhua, Zhejiang 321000, China Chinese Academy of Inspection and Quarantine, No. 3 Gaobeidian North Road, Chaoyang District, Beijing 100123, China; College of Environmental and Chemical Engineering, Yanshan University, Qinhuangdao 066004, China School of Chemical and Material Engineering Jiangnan University 214122 Wuxi China Department of Chemistry, Fudan University, Shanghai 200433, P. R. China The Institute of Chemistry and the Lise Meitner-Minerva Center for Computational Quantum Chemistry, Hebrew University of Jerusalem, Givat Ram Campus, 91904 Jerusalem, Israel, Biometal Science Laboratory, RIKEN SPring-8 Center, Hyogo 679-5148, Japan, and Department of Biotechnology, Faculty of Engineering, and Biotechnology Research Center, Toyama Prefectural University, Toyama 939-0398, Japan Department of Respiratory Medicine Jinhua Municipal Central Hospital Jinhua China Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, Colorado 80523-1870 The First Affiliated Hospital of Soochow UniversitySuzhou, China College of Materials Science and Engineering, Qingdao University, Qingdao 266071, China Department of Epidemiology, School of Public Health Fourth Military Medical University Xi'an China Department of Pharmacology and Pharmacy The University of Hong Kong Hong Kong China State and Local Joint Engineering Laboratory for Novel Functional Polymeric Materials, Suzhou Key Laboratory of Macromolecular Design and Precision Synthesis, Jiangsu Key Laboratory of Advanced Functional Polymer Design and Application, Department of Polymer Science and Engineering, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, P. R. China Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA College of Animal Science and Technology, Hebei Agricultural University, Baoding 071001, China *Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104; School of Environment, Guangzhou Key Laboratory of Environmental Exposure and Health, and Guangdong Key Laboratory of Environmental Pollution and Health, Jinan University, Guangzhou 510632, China Department of Pathology, Jinling Hospital, Clinical School of Nanjing University Medical College, Nanjing, China. Beijing Key Laboratory of Microanalytical Methods and Instrumentation, Department of Chemistry, Tsinghua University, Beijing, 100084, People’s Republic of China College of Environmental Science and Engineering, Hunan University, Lushan South Road, Yuelu District, Changsha 410082, People’s Republic of China; Key Laboratory of Environmental Biology and Pollution Control, Hunan University, Ministry of Education, Lushan South Road, Yuelu District, Changsha 410082, People’s Republic of China Division of Anti-Tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, P.R. China. Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, School of Pharmaceutical Sciences, Chongqing University, Chongqing, 401331, P. R. China Department of Interventional Therapy, Beijing Cancer Hospital, Beijing Institute for Cancer Research, Peking University School of Oncology, Beijing 100036, China. School of Life Sciences, University of Technology Sydney, Sydney, New South Wales, Australia Chinese Academy of Sciences 1 Institute of Plasma Physics, , P.O. Box 1126, Hefei, Anhui 230031, People's Republic of China Department of Emergency Medicine, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou; Authors' Affiliations: 1Department of Liver Disease and Digestive Interventional Radiology, Xijing Hospital of Digestive Diseases, Xijing Hospital; 2Department of Medical Statistics; and 3State Key Laboratory of Cancer Biology and Xijing Hospital of Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi'an, China Reproductive and Genetic Hospital of CITIC‐Xiangya Changsha China; Clinical Research Center or Reproduction and Genetics in Hunan Province Changsha China Key Laboratory of Algal Biology Institute of Hydrobiology, the Chinese Academy of Sciences Wuhan Hubei 430072 China Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, California;; Department of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, California; Barcelona Hepatic Hemodynamic Laboratory, Liver Unit,Barcelona,Spain Department of Hand Surgery, Huashan Hospital, Fudan University, Shanghai, China. Department of Microrepair and Reconstructive Surgery, Traditional Chinese Medicine Hospital of Xinjiang Uyghur Autonomous Region, Urumqi, China. Key Laboratory of Trauma Repair and Reconstruction, Xinjiang, China. School of Traffic and Transportation, Beijing Jiaotong University, Beijing 100044, China College of Life Science, Sichuan Agricultural University, Ya’an, 625014, Sichuan, China Institute of Chemistry and The Lise Meitner-Minerva Center for Computational Quantum Chemistry, The Hebrew University of Jerusalem, 91904 Jerusalem, Israel, and Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, Katahira, Sendai, 980-8577, Japan Agro‐Product Safety Research Center Chinese Academy of Inspection and Quarantine No. 11 Ronghua South Road Daxing District Beijing 100176 China COMOC-Center for Ordered Materials, Organometallics and Catalysis Department of Chemistry Ghent University Krijgslaan 281-S3 9000 Ghent Belgium London Research and Development Centre, Agriculture and Agri‐Food Canada Ottawa ON Canada N5T 4T3; Department of Biology University of Western Ontario London ON Canada N6A 5B7 State Key Laboratory of Proteomics Beijing Proteome Research Center Beijing Institute of Lifeomics Beijing China State Key Laboratory of Superlattices and Microstructures, Institute of Semiconductors, Chinese Academy of Sciences, P.O. Box 912, Beijing 100083, China Developmental Biology and Regenerative Medicine Program and Department of Surgery, Children's Hospital Los Angeles, Los Angeles; From the Departments of Interventional Oncology (K.Z., X.Z., S.F., G.C., L.X., H.C., D.W., R.Y., X.W.), Cancer Epidemiology (W.Q.L.), Hepatic and Biliary Surgery (K.W., W.L., H.W., Q.B., M.L., C.H., B.X.), and Gastrointestinal Oncology (L.S.), Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Peking University Cancer Hospital and Institute, Beijing 100142, China. Department of Cardiology, Fujian Provincial Hospital, Fuzhou, China; and Jiangsu Key Laboratory of Pediatric Respiratory Disease, Institute of Pediatrics, Medical Metabolomics Center, Pediatrics Department Affiliated Hospital of Nanjing University of Chinese Medicine Nanjing China Department of Microbiology and Immunology, University of California, San Francisco, CA 94143, U.S.A. Geriatric Medicine, Northern Jiangsu People's Hospital and Clinical Medical College of Yangzhou University, Yangzhou, China Institute of Theoretical and Computational Chemistry School of Chemistry and Chemical Engineering Nanjing University Nanjing 210093 China Department of Neurobiology, Northwestern University, Evanston, United States; Department of Psychology, University of Virginia, Charlottesville, United States; Department of Biology, University of Virginia, Charlottesville, United States Vascular Anomaly Center Group Department of Plastic and Reconstructive Surgery Shanghai Ninth People's Hospital School of Medicine Shanghai Jiaotong University Shanghai China Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences, School of Life Sciences, East China Normal University, Shanghai 200241, China Advanced Photonics Center, School of Electronic Science and Engineering, Southeast University, Nanjing 210096, China JBS International, Inc., North Bethesda, MD, USA Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co‐innovation Center of Neuroregeneration Nantong University Nantong China Department of Gastroenterology, Chongqing Cancer Institute & Hospital & Cancer Center, Chongqing, China School of Information Engineering, Jiangxi University of Science and Technology, Ganzhou, China Department of Pathology, Jinling Hospital, Jinling School of Clinical Medicine, Nanjing Medical University, Nanjing, China Department of Pediatrics, Fujian Medical University Union Hospital, Fuzhou 350001, China. yanhui_0655@126.com. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China. From the Department of Neurology (B.X., M.Z., S.Z.), Department of Orthopaedics (D.Z.), and Department of Oncology (R.J.), Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, and the Department of Urology (H.C., X.L.), Renmin Hospital of Wuhan University, Wuhan, China. Department of Neurobiology, Neuroscience Research Institute, Peking University Health Science Center, Beijing 100191, China Department of Gastrointestinal Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, China (mainland) Department of Pathology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China; Collaborative Innovation Center for Respiratory Disease Diagnosis and Treatment & Chinese Medicine Development of Henan Province, Henan University of Chinese Medicine, Zhengzhou 450046, China Shanghai Public Health Clinical Center affiliated to Fudan University, Shanghai 201508, PR China; Key Laboratory of Medical Molecular Virology, Ministry of Education and Public Health, Shanghai Medical College, Fudan University, Shanghai 200032, PR China Department of Infectious Disease, State Key Laboratory of Virology, Renmin Hospital of Wuhan University, Wuhan 430060, China. Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Molecular Recognition and Function, and ‡CAS Key Laboratory of Photochemistry, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China Key Laboratory of Organic Synthesis of Jiangsu Province Soochow University Suzhou 215123 People's Republic of China Lawrence Livermore National Laboratory 1 , Livermore, California 94550-9234, USA Department of Spine, Gulou Hospital, Nanjing University Medical School, Nanjing 210008, China. chen_hui82@hotmail.com Department of Endodontics, Jinan Stomatological Hospital, Jinan, Shandong, China Department of Otolaryngology–Head and Neck Surgery Beijing TongRen Hospital, Capital Medical University Beijing China; Beijing Key Laboratory of Nasal Diseases Beijing Institute of Otolaryngology Beijing China; Department of Allergy, Beijing TongRen Hospital Capital Medical University Beijing China Department of Endodontics, Jinan Stomatological Hospital, Jinan, Shandong 250001, P.R. China Key Laboratory of Automobile Materials, Ministry of Education, College of Materials Science and Engineering, Jilin University, Changchun 130025, P. R. China; State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry, Jilin University, Changchun 130012, P. R. China School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Department of heart center Capital Medical University Affiliated Beijing Friendship Hospital Institute of Chemistry, Henan Academy of Sciences, Zhengzhou 450002, China Department of Burns and Plastic Surgery, Beijing Jishuitan Hospital, Beijing, P.R. China College of Life Sciences Zhejiang University Hangzhou China Department of Dermatology Wuhan No. 1 Hospital Wuhan China Department of Obstetrics, People’s Hospital of Guangxi Zhuang Autonomous Region, Nanning, P.R. China School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China OrigiMed Shanghai China Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. BNLMS CAS Key Laboratory of Photochemistry, Institute of Chemistry Chinese Academy of Sciences Beijing 100190 China Department of General Surgery, Zhejiang Hospital, Hangzhou Department of Immunology, School of Medicine, Yangtze University, Jingzhou, China State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, Guangdong, People's Republic of China The Co-construction Laboratory of Microbial Molecular Biology of Province Department and Ministry of Science and Technology, College of Life Sciences, Hunan Normal University, Changsha, Hunan, 410081, People’s Republic of China School of Life Sciences Faculty of Science University of Technology Sydney Broadway NSW Australia Beijing National Laboratory for Molecular Sciences, Key Laboratory of Organic Solids, nstitute of Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China 1Trillium Therapeutics Inc., Mississauga, Ontario, Canada. National Key Discipline of Pediatrics (Capital Medical University), Ministry of Education, Emergency Center, Beijing Children's Hospital, Beijing 100045, China. State Key Laboratory for Conservation and Utilization of Subtropical Agro‐Bioresources (South China Agricultural University), Guangdong Key Laboratory for Innovative Development and Utilization of Forest Plant Germplasm, College of Forestry and Landscape Architecture South China Agricultural University Guangzhou China; College of Forestry Northwest A&F University Yangling China Department of Radiology, Southwest Hospital, Third Millitary Medical University (Army Medical University), Chongqing, 400038, China Department of Cardiac Surgery, Zhongshan Hospital, Fudan University, Institute of Cardiovascular Diseases of Fudan University, Shanghai, China; and the College of Food Science and Engineering Ocean University of China Qingdao 266003 P. R. China Key Laboratory of Industrial Ecology and Environmental Engineering (Ministry of Education), School of Environmental Science and Technology, Dalian University of Technology, Dalian 116024, China Departments of Department of Plastic and Reconstructive Surgery School of Medicine Shanghai Ninth People’s Hospital Shanghai Jiaotong University Shanghai China Wallenberg Wood Science Center Department of Fibre and Polymer Technology KTH Royal Institute of Technology Stockholm SE‐100 44 Sweden Department of Critical Care Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China ZJU-NHU United R&D Center, Department of Chemistry, Zhejiang University, Hangzhou 310027, China Clinc Lab Center The Third Xiangya Hospital of Central South University China Department of Clinical Laboratory, Xinhua Hospital Shanghai Jiao Tong University School of Medicine Shanghai China Beijing National Laboratory for Molecular Sciences (BNLMS); CAS Key Laboratory of Photochemistry; Institute of Chemistry; Chinese Academy of Sciences; Beijing, China Chinese Academy of Agricultural Sciences Tea Research Institute, , Hangzhou 310008, China; Graduate School of Chinese Academy of Agricultural Sciences , Beijing, 100081, PR China Clinical Laboratories, The First Affiliated Hospital of Chongqing Medical University, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China College of Food Science and Engineering, Jiangxi Agricultural University, Nanchang 330045, China. Department of Tuberculosis, The Fifth People's Hospital of Suzhou, Suzhou, China Wadsworth Center, New York State Department of Health, 120 New Scotland Avenue, Albany, New York 12208, United States Key Laboratory of Applied Marine Biotechnology, Ningbo University, Ministry of Education, Ningbo 315211, China. chenamy1986@163.com Department of Cardiology, Renmin Hospital of Wuhan University, Cardiovascular Research Institute, Wuhan University, Hubei Key Laboratory of Cardiology, Wuhan, Hubei, China Department of Anatomy, Medical College of Nanchang University, China Hubei Provincial Center for Disease Control and Prevention, Wuhan, China Institute of Functional Nano and Soft Materials Jiangsu Key Laboratory for Carbon‐Based Functional Materials and Devices Collaborative Innovation Center of Suzhou Nano Science and Technology Joint International Research Laboratory of Carbon‐Based Functional Materials and Devices Soochow University 199 Renai Road, Suzhou Industrial Park Suzhou Jiangsu 215123 China College of Pharmacy, Guilin Medical University, Guilin 541004, People’s Republic of China Department of Clinical Laboratory, Xinhua Hospital, affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China Centre for Research and Intervention on Suicide and Euthanasia, Université du Québec à Montréal, Canada; School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, China Beijing National Laboratory for Molecular Sciences (BNLMS), CAS Key Laboratory of Photochemistry, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, China Department of Radiology Southwest Hospital, Army Medical University (Third Military Medical University) Chongqing China Key Laboratory of Cell Engineering in Guizhou Province, Affiliated Hospital of Zunyi Medical University, Zunyi 563000, Guizhou, China Department of VIP Center, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University, No. 44-1 Wenhua Road West, 250012 Jinan, China; Department of Endodontics, Jinan Stomatology Hospital, No. 101 Jingliu Road, 250001 Jinan, China School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, China; Department of Radiology, Southwest Hospital Army Medical University (Third Military Medical University) Chongqing China Ministry of Education Key Laboratory for Biodiversity Science and Ecological Engineering, and Institute of Biodiversity Science, Fudan University, Shanghai 200433, China Department of Oral Radiology, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and Vrije Universiteit Amsterdam, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and Vrije Universiteit Amsterdam, Amsterdam, The Netherlands; Department of Oral Kinesiology, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and Vrije Universiteit Amsterdam, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and Vrije Universiteit Amsterdam, Amsterdam, The Netherlands University of Pittsburgh Institute for Nanoscale Technology, University of Technology Sydney, PO Box 123, Broadway, NSW 2007, Sydney, Australia; School of Medical & Molecular Biosciences, University of Technology Sydney, PO Box 123, Broadway, NSW 2007, Sydney, Australia; Centre for Health Technologies, University of Technology Sydney, PO Box 123, Broadway, NSW 2007, Sydney, Australia Department of Ultrasonic Medicine First Affiliated Hospital of Guangxi Medical University Nanning China College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China Department of Dermatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China *State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China 100101; and Medical Group Office Northern Jiangsu People's Hospital Yangzhou China Hypertension-Endocrine Branch, National Heart, Lung, and Blood Institute (H.C., L.-N.C., Y.L., M.J.Q.), National Institutes of Health, Bethesda, Maryland 20892; NHC Key Laboratory of Pulmonary Immune‐related Diseases Guizhou Provincial People’s Hospital Guiyang China State Key Laboratory of Plant Genomics, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China State Key Laboratory of Solidification Processing, Northwestern Polytechnical University, Xi’an 710072, China Department of Epidemiology School of Public Health Fourth Military Medical University Xi'an Shannxi 710032 China Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (MOE), School of Pharmacy, Shandong University, Jinan, Shandong 250012, China State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China Department of Pediatrics Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine Tianjin City China School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China School of Food Science and Technology, National Engineering Research Center of Seafood, Dalian Polytechnic University, Dalian, Liaoning 116034, People’s Republic of China State Key Laboratory of Luminescent Materials and Devices, Institute of Polymer Optoelectronic Materials and Devices, and ‡State Key Laboratory of Pulp & Paper Engineering, School of Light Industry and Food Science, South China University of Technology, Guangzhou 510640, P. R. China Key Laboratory of Design and Assembly of Functional Nanostructures, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian 350002, P. R. China State Key Lab of Plant Genomics, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, 100101 Beijing, China;; University of Chinese Academy of Sciences, 100049 Beijing, China; School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. China Rehabilitation Research Center, Beijing 100068, People's Republic of China Department of Ophthalmology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States Department of Obstetrics and Gynecology, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China (mainland) Department of Critical Care Medicine The First Affiliated Hospital of Shenzhen University/Shenzhen Second People's Hospital Guangdong China Satellite Environmental Application Center, Ministry of Environmental Protection, Beijing 100094, China. Advanced Photonics Center, Southeast University, 2# Sipailou, Nanjing 210096, Jiangsu China Department of Neurology, Military General Hospital of Beijing PLA, Beijing 100700, P.R. China Division of Hematology/Oncology Brookdale University Hospital Medical Center Brooklyn NY USA Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China School of Geology and Mining Engineering, Xinjiang University, Urumqi 830046, China; Key Laboratory of Environmental Protection Mining for Minerals Resources, Education Department of Xinjiang Uygur Autonomous Region, Xinjiang University, Urumqi 830046, China; School of Resources and Safety Engineering, Central South University, Changsha 410083, China State Key Laboratory for Superlattice and Microstructures, Institute of Semiconductors, Chinese Academy of Sciences, Beijing 100083, China Key Laboratory of Systems Biomedicine (Ministry of Education) and Collaborative Innovation Center of Systems Biomedicine of Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai-MOST Key Laboratory for Disease and Health Genomics, Chinese National Human Genome Center at Shanghai, Shanghai, China *Department of Physiology and Cell Biology, University of Nevada School of Medicine, Reno, NV 89557; and From the Departments of Ophthalmology and Visual Sciences and Key Laboratory for Advanced Materials and Institute of Fine Chemicals East China University of Science and Technology Meilong Road 130 Shanghai 200237 P.R. China Department of Psychology and Behavioral Sciences, Zhejiang University, Hangzhou, People's Republic of China Department of Urology Guangzhou First People's Hospital Guangzhou Medical University Guangzhou Guangdong China Department of Burns and Plastic Surgery, Beijing Jishuitan Hospital, Beijing Department of Oral Health Sciences, Faculty of Dentistry, University of British Columbia, Vancouver, BC, Canada Shengli Clinical Medical College of Fujian Medical University, Fuzhou, Fujian, PR China; Fujian Provincial Hospital, 134 East Street, Fuzhou, Fujian 350001, PR China Department of Biology and Biochemistry; University of Houston; Houston; USA The Fifth People's Hospital of Suzhou, Suzhou, P.R. China. The State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai 200031, China. Department of Clinical Laboratory, China Rehabilitation Research Center , Beijing , P.R. China Institute of Biological Chemistry, Washington State University, Pullman, Washington 99164-6340 Clinical Medical College of Yangzhou University, Northern Jiangsu People's Hospital, Yangzhou, 225001, China Lawrence Livermore National Laboratory 1 , 7000 East Avenue, Livermore, California 94550, USA Department of Immunology, Medical College, Wuhan University of Science and Technology, Wuhan, Hubei, PR China. Key Laboratory of Algal Biology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, Hubei China School of Pharmacy, Guilin Medical University, Guilin, China Epithelial Cell Biology Research Centre School of Biomedical Sciences Faculty of Medicine The Chinese University of Hong Kong Hong Kong China Epithelial Cell Biology Research Centre School of Biomedical Sciences The Chinese University of Hong Kong Shatin NT Hong Kong Department of Chemistry, Peking University, Beijing, 100871, China, and Institute of Materials Research and Engineering, National University of Singapore, 117602, Singapore Jinhua Hospital of Zhejiang University, Jinhua Central Hospital, Jinhua Center for Clinical Molecular Medicine, Children's Hospital of Chongqing Medical University//Ministry of Education Key Laboratory of Child Development and Disorders//Key Laboratory of Pediatrics in Chongqing//Chongqing International Science and Technology Cooperation Center for Child Development and Disorders, Chongqing 400014, China.E-mail: stella8848@163.com. Department of Emergency, Loudi Central Hospital, Loudi Hu'nan Province, China. Department of Cardiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China School of Nursing Tianjin Medical University Tianjin China Department of Gastroenterology, Changhai Hospital, The Second Military Medical University, Shanghai College of Life Science and Engineering Research Center of Ecology and Agricultural Use of Wetland Ministry of Education, Yangtze University Jingzhou China; Research Center of Milu Health and Habitat Yangtze University Jingzhou China Department of Infectious Diseases, Children's Hospital of Fudan University, Shanghai 200032, China. College of Grassland Science, Gansu Agricultural University, Lanzhou 730070, China; Key Laboratory of Grassland Ecosystem, Gansu Agricultural University, Lanzhou 730070, China WuXi AppTec, 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131, China Geriatrics Digestion Department of Internal Medicine, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China Center for Disease Control and Prevention of Chinese People's Liberation Army, Beijing, China. College of Animal Science and Technology, Hebei Agricultural University, Baoding, China Department of Pharmacology Institute of Edible Fungi; Shanghai Academy of Agricultural Sciences; Shanghai; P.R. China Department of Chemistry, South University of Science and Technology of China, Shenzhen 518055, China College of Science, Shenyang University of Chemical Technology, Shenyang 110142, China Shanghai Jiao Tong University – The Chinese University of Hong Kong Joint Research Center for Human Reproduction and Related Diseases Shanghai China; Epithelial Cell Biology Research Center School of Biomedical Sciences Faculty of Medicine The Chinese University of Hong Kong Hong Kong Hong Kong; Key Laboratory for Regenerative Medicine (Jinan University – The Chinese University of Hong Kong) Ministry of Education Hangzhou China Department of Plastic and Reconstructive Surgery, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Department of Food Science and Engineering; National Engineering Research Center of Seafood; Dalian Polytechnic University; Dalian 116034; China Institute of Agroecology, Fujian Agriculture and Forestry University, Fuzhou 350002, China. Ivyhuichen@163.com Key Laboratory of Animal Protein Food Deep Processing Technology of Zhejiang Province, College of Food and Pharmaceutical Sciences, Ningbo University, Ningbo 315832, China Research Center for Molecular and Developmental Biology, Key Laboratory of Photosynthesis and Environmental Molecular Physiology, Institute of Botany, The Chinese Academy of Sciences, Beijing 100093, China Department of Infectious Disease Prevention and Control Center for Disease Control and Prevention of Chinese People's Liberation Army Beijing China Hypertension-Endocrine Branch National Heart, Lung, and Blood Institute National Institutes of Health Bethesda, Maryland 20892 School of Pharmaceutical Science Wenzhou Medical University Wenzhou P.R. China Department of Orthopaedics, Zhongda Hospital, Southeast University, Nanjing, Jiangsu, People's Republic of China;; Trauma Center, Zhongda Hospital, Southeast University, Nanjing, Jiangsu, People's Republic of China; and; Orthopaedic Trauma Institute (OTI), Southeast University, Nanjing, Jiangsu, People's Republic of China. Meta Platforms Inc., Reality Labs Research, Menlo Park, California Department of Immunology, Research Center on Pediatric Development and Diseases, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical College, State Key Laboratory of Medical Molecular Biology, Beijing, China School of Sports and Health Management, Chongqing University of Education, Chongqing 400067, China Key Lab for Agro-product Processing and Quality Control of Nanchang City; College of Food Science and Engineering; Jiangxi Agricultural University; Nanchang 330045; China Clinical Medicine College, Weifang Medical University, Weifang China; Department of Allergy, The First Affiliated Hospital of Weifang Medical University/ Weifang People’s Hospital, Weifang China School of Public Health and the Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou Zhejiang China Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, and Jiangsu Provincial Key Lab of Pulp and Paper Science and Technology, Nanjing Forestry University, Nanjing 210037, P. R. China Department of Obstetrics, Affiliated Hospital of Jining Medical University, Jining, Shandong, China †Division of Nutritional Sciences, Cornell University, Ithaca, NY 14853 OrigiMed, Shanghai, People's Republic of China Hunan Key Laboratory of Biomedical Nanomaterials and Devices, Hunan University of Technology, Zhuzhou, 412007, China College of Science and Technology, Ningbo University, Ningbo, Zhejiang 315211, People’s Republic of China State Key Laboratory of Crop Stress Adaptation and Improvement, School of Life Sciences, Henan University, Kaifeng, China; Academy for Advanced Interdisciplinary Studies, Henan University, Kaifeng, China Department of Ophthalmology, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China Clinical Epidemiology Unit Qilu Hospital of Shandong University Jinan China College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China School of Chemical Engineering Sichuan University Chengdu 610065, Sichuan P. R. China School of Biomedical Engineering Capital Medical University Beijing P. R. China School of Science, Zhejiang Sci-tech University, Hangzhou, China. Department of Hepatobiliary-Pancreatic Surgery, The Second Affiliated Hospital of Wenzhou Medical College, Wenzhou, Zhejiang 325027, China Diabetes Unit, Laboratory of Clinical Investigation, National Center for Complementary and Alternative Medicine, National Institutes of Health, Bethesda, 20892; and Ophthalmology Department, Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu City, Sichuan Province 610072, People’s Republic of China Hunan Key Laboratory of Biomedical Nanomaterials and Devices, Hunan University of Technology, Zhuzhou 412007, Hunan, China Shanghai Key Laboratory of Atmospheric Particle Pollution and Prevention, Department of Environmental Science and Engineering, Institute of Atmospheric Sciences, Fudan University, Shanghai 200438, China State Key Laboratory of Conservation and Utilization of Subtropical Agro‐Bioresources, Guangdong Laboratory for Lingnan Modern Agriculture, Guangdong Key Laboratory for Innovative Development and Utilization of Forest Plant Germplasm, College of Forestry and Landscape Architecture South China Agricultural University Guangzhou Guangdong China Key Laboratory of Drug Targeting and Drug Delivery Systems, Ministry of Education, Sichuan University, 29 Wangjiang Rd, Chengdu, Sichuan 610041, People’s Republic of China State Key Laboratory of Proteomics, Beijing Proteome Research Center Beijing Institute of Radiation Medicine, Beijing, People’s Republic of China Department of Gastroenterology, Changhai Hospital, Naval Medical University, Shanghai, China. Pediatrics Center, Zhujiang Hospital, Southern Medical University, Guangzhou 510280, China. Department of Immunology, CAMS Key Laboratory for T Cell and Immunotherapy, State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical College, Beijing 100005, China; Changzhou Xitaihu Institute for Frontier Technology of Cell Therapy, Changzhou, Jiangsu 213000, China; Haihe Laboratory of Cell Ecosystem, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300020, China. Gastroenterology Department, Jinhua Wenrong Hospital, Jinhua City, Zhejiang Province, China Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology , Wuhan, Hubei , China School of Medical and Molecular Biosciences, Faculty of Science, Centre for Health Technology, University of Technology Sydney, Sydney, New South Wales, Australia; School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, China;; Collaborative Innovation Center for Respiratory Disease Diagnosis, Treatment & Chinese Medicine Development of Henan Province, Henan University of Chinese Medicine, Zhengzhou, China; School of Pharmaceutical Sciences, Chongqing University, Chongqing, China State Key Laboratory of Electronic Thin Film and Integrated Devices University of Electronic Science and Technology of China Chengdu 610054 P. R. China; State Key Laboratory of Marine Resource Utilization in South China Sea Hainan University Haikou 570228 P. R. China Department of Urology The Sixth Affiliated Hospital of Guangzhou Medical University Qingyuan China; Department of Urology Guangdong Provincial Work Injury Rehabilitation Hospital of Jinan University Guangzhou China Chimie ParisTech PSL University CNRS Institut de Recherche de Chimie Paris 11 rue Pierre et Marie Curie 75231 Paris France Department of Pediatric Surgery, Fujian Maternity and Child Health Hospital Affiliated Hospital of Fujian Medical University Fuzhou China Chinese Academy of Inspection and Quarantine, No. 3 Gaobeidian North Rd 100123, Chaoyang District, Beijing, People’s Republic of China State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China. Center for Craniofacial Molecular Biology, University of Southern California, Los Angeles 90033; Institute of Rehabilitation Science of ChinaChina Rehabilitation Research Center, Beijing, P. R. China Clinical Epidemiology Unit Qilu Hospital of Shandong University Jinan China; Clinical Research Center of Shandong University Jinan China |
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