author/MD5_5b6b815a9ccfef3548aca7814239c780

http://rdf.ncbi.nlm.nih.gov/pubchem/author/MD5_5b6b815a9ccfef3548aca7814239c780

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Predicate	Object
family-name	Wang Xiang Wang
name	Xiang Wang
given-name	Xiang
organization-name	College of Chemistry and Chemical Engineering, Central South University, Changsha, Hunan 410083, China Department of Pharmacy Affiliated Hangzhou First People's Hospital Zhejiang University School of Medicine Hangzhou Zhejiang China Institute of Forensic Science, Jiading Branch of Shanghai Public Security Bureau, Shanghai 201800, P.R. China Key Laboratory of Eutrophication and Red Tide Prevention of Guangdong Higher Education Institutes College of Life Science Jinan University Guangzhou People's Republic of China Department of Pharmaceutical Analysis, China Pharmaceutical University, 210009 Nanjing, China Department of Surgery, Xuzhou Central Hospital, Xuzhou, China. From the Medical Psychological Center, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China; the Laboratory of Applied Brain and Cognitive Sciences, Shanghai International Studies University, Shanghai, China; and the Center for Functional Neuroimaging, Department of Neurology, University of Pennsylvania, Philadelphia. State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guizhou University, Huaxi District, Guiyang 550025, People’s Republic of China; College of Chemistry and Materials Engineering, Kaili University, Kaili 556011, People’s Republic of China Department of Orthopaedics, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201999, P.R. China From the Department of Hepatobiliary Surgery, Southwest Hospital, Third Military Medical University (Amy Medical University), Chongqing, China. Medical Institute of Psychology Second Xiangya Hospital of Central South University Department of Medicine, Division of NanoMedicine, ‡Center for Environmental Implications of Nanotechnology, California NanoSystems Institute, §Department of Chemistry and Biochemistry, ⊥Electron Microscopy Core Facility, California NanoSystems Institute, ∥Department of Molecular, Cell, and Developmental Biology, #Department of Materials Science and Engineering, ∇California NanoSystems Institute, University of California, Los Angeles, Los Angeles, California 90095, United States Department of Materials Science and Engineering, City University of Hong Kong, Kowloon, Hong Kong SAR 999077, P. R. China 3Department of Thoracic Surgery, Second Xiangya Hospital, Central South University, Changsha, China. Institute of Applied Chemistry College of Chemistry Nanchang University Nanchang 330031 P. R. China Division of Vascular Surgery, East Hospital Tongji University School of Medicine Shanghai China State Key Laboratory of Medicinal Chemical Biology, Research Center for Analytical Sciences, Tianjin Key Laboratory of Molecular Recognition and Biosensing, and Frontiers Science Center for New Organic Matter, College of Chemistry, Nankai University, Tianjin 300071, China. Center for Applied Genomics, Children’s Hospital of Philadelphia, Philadelphia, PA; and National Engineering Research Center for Colloidal Materials School of Chemistry and Chemical Engineering Shandong University Jinan Shandong 250100 P. R. China CAS Key Laboratory of Molecular Nanostructure and Nanotechnology, CAS Research/Education Center for Excellence in Molecular Sciences, Beijing National Laboratory for Molecular Science (BNLMS), Institute of Chemistry, Chinese Academy of Sciences, Beijing100190, China Department of Oncology, Xuzhou Central Hospital, Xuzhou Medical University, Xuzhou, Jiangsu, China Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, Shanghai 200050, PR China. Department of Breast Surgical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China Key Laboratory of Environmental and Applied Microbiology Chinese Academy of Sciences & Environmental Microbiology Key Laboratory of Sichuan Province Chengdu Institute of Biology Chinese Academy of Sciences Sichuan 610041 China National Key Laboratory of Crop Genetic Improvement and National Centre of Plant Gene Research, Huazhong Agricultural University, Wuhan, China School of Biological Engineering, Chongqing University, Chongqing 400030, P.R.China.xwangchn@vip.sina.com. Institute of Cancer Stem Cell, Cancer Center, Dalian Medical University, Dalian, 116044, Liaoning, P.R. China School of Materials Science and Engineering, Tianjin University, Tianjin 300072, People’s Republic of China; School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan Department of Vascular Surgery, Taizhou Hospital of Zhejiang Province Department of Intervention,The fourth affiliated Hospital of China Medical University, Shenyang, Liaoning, China College of Chemistry; Chemical Engineering and Materials Science; Soochow University; Suzhou 215123; China Department of Thoracic Surgery, The Second Xiangya Hospital, Central South University, Changsha 410011, China; Cancer Research Institute, Central South University, Changsha 410011, China; Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Changsha 410011, China; Key Laboratory of Carcinogenesis, Ministry of Health, Changsha 410011, China Department of Chemistry and Biochemistry, University of Colorado, Boulder, Colorado 80309 Department of Clinical Medicine, School of Medicine, Nankai University, Tianjin 300071, China Department of Laboratory Medicine, The First Affiliated Hospital of Huzhou University, The First People's Hospital of Huzhou, Huzhou, Zhejiang 313000, P.R. China Wangxiang@xysm.net Department of Urology the Langdong Hospital of Guangxi Medical University Nanning China; Department of Urology the First Affiliated Hospital of Guangxi Medical University Nanning China Binzhou Medical University Yantai China Department of Neurology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, P. R. China; Department of Neurology, Shandong Provincial Hospital affiliated to Shandong First Medical University, Jinan, Shandong, P. R. China; Shandong Provincial Clinical Research Center for Geriatric Neurological Diseases, Jinan, Shandong, P. R. China California NanoSystems Institute, Department of Civil & Environmental Engineering, Department of Medicine-Division of NanoMedicine, Department of Environmental Health Sciences, and Department of Chemistry and Biochemistry, University of California at Los Angeles, Los Angeles, California 90095 Technical Center for Multifunctional Magneto-Optical Spectroscopy (Shanghai); Engineering Research Center of Nanophotonics & Advanced Instrument (Ministry of Education); Department of Materials; School of Physics and Electronic Science; East China Normal University Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI 48109; and Jiangsu Key Laboratory for Chemistry of Low-Dimensional Materials, School of Chemistry and Chemical Engineering, Huaiyin Normal University, Huaian 223300, P. R. China The Affiliated Changzhou No. 2 People’s Hospital of Nanjing Medical University, Changzhou 213164, Jiangsu, P. R. China Department of Chemistry Queen's University Kingston Ontario K7L 3N6 Canada Department of Pharmacy, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China Department of Critical Care Medicine, Nanjing First Hospital Huzhou Central Hospital, Zhejiang, Huzhou 313000, China. Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China. Center for Biosystems Research, University of Maryland Biotechnology Institute, 5115 Plant Sciences Building, College Park, Maryland 20742, Department of Physics, Institute for Physical Sciences and Technology, and Institute for Research in Electronics and Applied Physics, and Department of Chemistry and Biochemistry, University of Maryland, College Park, Maryland 20742, and Department of Chemical and Biochemical Engineering, University of Maryland, Baltimore County, 1000 Hilltop Circle, Baltimore,... Department of Emergency Medicine, Hainan General Hospital Hainan Affiliated Hospital of Hainan Medical University Haikou People's Republic of China Institute of Bismuth Science and College of Science, University of Shanghai for Science and Technology, Shanghai 200093, China Shi's Center of Orthopedics and Traumatology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China. Department of Breast Surgical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing , People’s Republic of China School of Materials Science and Engineering, Nanjing University of Science and Technology, Nanjing 210094, China Engineering Research Center for Optoelectronics of Guangdong Province, School of Physics and Optoelectronics, South China University of Technology, Guangzhou 510640, China State Key Laboratory of Physical Chemistry of Solid Surface, The MOE Key Laboratory of Spectrochemical Analysis & Instrumentation, Collaborative Innovation Center of Chemistry for Energy Materials (iChEM), College of Chemistry and Chemical Engineering, and ‡Department of Physics, Xiamen University, Xiamen 361005, China The First Clinical Medical College of Zhejiang Traditional Chinese Medical University Hangzhou China State Key Laboratory of Crop Stress Biology in Arid Area/College of Life Sciences Northwest A&F University Yangling Shaanxi China Department of Endocrinology Affiliated Hospital of Qingdao University Qingdao 266003 P. R. China Key Lab of Organic Optoelectronics and Molecular Engineering of Ministry of Education, Department of Chemistry, Tsinghua University, Beijing, P. R. China Department of Neurology Shandong Provincial Hospital affiliated to Shandong University Jinan Shandong province PR China School of Environmental and Chemical Engineering, Tianjin Polytechnic University, Tianjin, P. R. China; State Key Laboratory of Separation Membranes and Membrane Processes, Tianjin Polytechnic University, Tianjin, P. R. China Department of Cardiology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing 100730, China; Graduate School of Peking Union Medical College, Chinese Academy of Medical Science, Beijing 100730, China Institute of Organic Chemistry and Advanced Materials, University of Ulm, Albert-Einstein-Allee 11, 89081 Ulm, Germany National Key Laboratory of Shock Wave and Detonation Physics, Institute of Fluid Physics, China Academy of Engineering Physics , Mianyang, Sichuan 621900, China Department of Materials Science and Engineering City University of Hong Kong Tat Chee Avenue, Kowloon Tong Hong Kong SAR P. R. China Department of Orthopedics, Tongde Hospital of Zhejiang Province, Hangzhou, Zhejiang, China Primary Care Center, Sichuan Provincial People's Hospital, Chengdu, Sichuan, China (mainland). Department of Chemistry, Queen’s University, Kingston, Ontario K7L 3N6, Canada Department of Oncology, Xuzhou Central Hospital, Xuzhou Medical UniversityXuzhouP.R. China Division of Nanomedicine Department of Medicine University of California Los Angeles CA 90095 USA; California NanoSystems Institute University of California Los Angeles CA 90095 USA From the Department of Radiology, Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430014, China Department of Ultrasound The Third Affiliated Hospital of Chongqing Medical University (Gener Hospital) Chongqing China Technical Center for Multifunctional Magneto-Optical Spectroscopy (Shanghai), Engineering Research Center of Nanophotonics & Advanced Instrument (Ministry of Education), Department of Materials, School of Physics and Electronic Science, East China Normal University, Shanghai 200241, China Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, PR China Division of Trauma Surgery, Emergency Surgery & Surgical Critical, Tongji Trauma Center, Tongji Medical College, Huazhong University of Science and Technology , Tongji Hospital, Wuhan 430030 , China; Department of Emergency and Critical Care Medicine, Tongji Medical College, Huazhong University of Science and Technology, Tongji Hospital , Wuhan 430030 , China COVID-19 Investigating and Research Team, Department of Radiology, Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Jiang’an District, Wuhan, Hubei, China Department of General Surgery, Hefei Hospital Affiliated to Medical University of Anhui , Hefei 230011 , Anhui , China State Key Laboratory of Physical Chemistry of Solid Surfaces, Collaborative Innovation Center of Chemistry for Energy Materials (i-ChEM), The MOE Key Laboratory of Spectrochemical Analysis & Instrumentation, Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science & Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou 215123, China; School of Chemistry and Chemical Engineering, Huaiyin Normal University, Huaian, 223300, China Department of Medical Oncology, Xuzhou Central Hospital, Xuzhou Medical University, Xuzhou, 221009, China State Key Laboratory of Powder Metallurgy, School of Materials Science and Engineering, Central South University, Changsha 410083, P. R. China Lanzhou University Second Hospital, Lanzhou, Gansu, China Department of Chemistry and Biochemistry, Queens College-CUNY, Flushing, New York 11367, United States; The Graduate Center of CUNY, New York, New York 10016, United States Department of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China; Department of Microbiology, Key Lab of Microbiological Engineering of Agricultural Environment, Ministry of Agriculture, College of Life Sciences, Nanjing Agricultural University, 210095 Nanjing, PR China Department of Respirology and Critical Care Medicine, Xuzhou Central Hospital, Xuzhou, China. Division of Anti-tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China Department of Neurosurgery, University of Texas Health Science Center at Houston, Houston, Texas, USA Vaccine Research Center, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, China Department of Neurology, Xuzhou Key Laboratory of Neurobiology, Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou, China; Department of Neurology Shandong Provincial Hospital Cheeloo College of Medicine Shandong University Jinan Shandong China; Shandong Provincial Clinical Research Center for Neurological Diseases Jinan Shandong China; Department of Neurology Shandong Provincial Hospital Affiliated to Shandong First Medical University Jinan Shandong China Department of Infection Control, Tianjin Haihe Hospital, Tianjin 300350, China. Faculty of Materials and Chemistry, China University of Geosciences, Wuhan 430074, P. R. China Institute of Bismuth Science; College of Science; University of Shanghai for Science and Technology; Shanghai 200093; China Department of Urology, Shanghai General Hospital Shanghai Jiao Tong University School of Medicine Shanghai China Key Laboratory of Biorheological Science and Technology (Chongqing University), Ministry of Education, Chongqing 400030, P.R. China. Medical Psychological Center, The Second Xiangya Hospital of Central South University, Changsha, Hunan, P. R. China; Medical Psychological Institute of Central South University, Changsha, Hunan, P. R. China; China National Clinical Research Center on Mental Disorders (Xiangya), Changsha, Hunan, P. R. China Radiotherapy Technology Center Of The Affiliated Hospital Of Qingdao University, Qingdao, Shandong, China SINOPEC Beijing Research Institute of Chemical Industry, Beijing 100013, China Center for Applied Genomics (CAG) Children's Hospital of Philadelphia Philadelphia Pennsylvania USA Technical Center for Multifunctional Magneto‐Optical Spectroscopy (Shanghai) Engineering Research Center of Nanophotonics & Advanced Instrument (Ministry of Education) Department of Materials School of Physics and Electronic Science East China Normal University Shanghai 200241 China Department of Mechanical Engineering, University of California, Berkeley, Berkeley, CA, USA Department of Thoracic and Cardiovascular Surgery, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China Department of Chemistry, Queens College, City University of New York, 6530 Kissena Boulevard Flushing, New York 11367, United States; The Graduate Center of CUNY, New York, New York 10016, United States Center for Environmental Implications of Nanotechnology, California NanoSystems Institute, ‡Department of Medicine, Division of NanoMedicine, and §Department of Chemistry and Biochemistry, University of California at Los Angeles, Los Angeles, California 90095, United States Medical Psychological Center The Second Xiangya Hospital of Central South University Changsha Hunan P. R. China; China National Clinical Research Center for Mental Disorders (Xiangya) Changsha Hunan P. R. China Institute of Biology and Medical Sciences Soochow University Suzhou China; Key Laboratory of Molecular Virology & Immunology Vaccine Research Center Institut Pasteur of Shanghai, Chinese Academy of Sciences Shanghai China Department of Hand Surgery, Ningbo Mingzhou Hospital of Yinzhou, Ningbo 315100, Zhejiang, China. Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, P. R. China Technical Center for Multifunctional Magneto-Optical Spectroscopy (Shanghai); Engineering Research Center of Nanophotonics Advanced Instrument (Ministry of Education); Department of Materials; School of Physics and Electronic Science; East China Normal University Digestive Endoscopy Center,The First Affiliated Hospital with Nanjing Medical University, and Jiangsu Province Hospital,Nanjing,People's Republic of China Department of Stomatology The First People's Hospital of Nantong, The Second Affiliated Hospital of Nantong University Nantong China Northeast Institute of Geography and Agroecology, Chinese Academy of Sciences Changchun China; University of Chinese Academy of Sciences Beijing China Department of Endocrinology Affiliated Hospital of Qingdao University Qingdao China National University of Singapore (Suzhou) Research Institute, 377 Linquan Street, Suzhou, Jiangsu 215123, China Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province Affiliated Hangzhou First People's Hospital Zhejiang University School of Medicine Hangzhou Zhejiang 310006 China; Department of Central Laboratory The First People's Hospital of Huzhou Huzhou Zhejiang 313000 China Center for Environmental Implications of Nanotechnology, California NanoSystems Institute, University of California Los Angeles, 570 Westwood Plaza, Los Angeles, California 90095, United States CAS Key Laboratory of Molecular Nanostructure and Nanotechnology; CAS Research/Education Center for Excellence in Molecular Sciences; Beijing National Laboratory for Molecular Science (BNLMS); Institute of Chemistry; Chinese Academy of Sciences Division of Anti-tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica (SIMM); Chinese Academy of Sciences; Shanghai 201203 China the Children’s Hospital of Fudan University, Shanghai, China Center for Environmental Implications of Nanotechnology, California NanoSystems Institute, University of California, Los Angeles, Los Angeles, California 90095, United States Howard Hughes Medical Institute, Broad Institute of Harvard and MIT, 7 Cambridge Center, Cambridge, Massachusetts 02142, and Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138 School of Science and Engineering, The Chinese University of Hong Kong, Shenzhen 518172, China Chemical Sciences Division and Center for Nanophase Materials Sciences Oak Ridge National Laboratory Oak Ridge TN 37831 USA College of Political Science and Law, Jiangxi Normal University, Jiangxi, Nanchang 330000, China State Key Laboratory of Physical Chemistry of Solid Surfaces, Collaborative Innovation Center of Chemistry for Energy Materials (iChEM), College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China;, Quantitative and Computational Biology Program Graduate School of Biomedical Sciences Baylor College of Medicine Houston Texas USA Key Laboratory of Environmental and Applied Microbiology, CAS, Environmental Microbiology Key Laboratory of Sichuan Province, Chengdu Institute of Biology, Chinese Academy of Sciences, Sichuan, People's Republic of China Department of Neurosurgery, Shunde Hospital of Southern Medical University, Foshan, China State Key Laboratory of Bioactive Substances and Function of Natural Medicine, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100050, China Institute of Fluid Physics, China Academy of Engineering Physics, Mianyang621900, China Nanjing First Hospital Nanjing Medical University Nanjing 210006 China Key Lab for Special Functional Materials of Ministry of Education, School of Materials, Henan University, Kaifeng 475004, Henan Province, PR China Institute of Cardiovascular Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China Department of Thoracic Surgery, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China College of Chemistry and Chemical Engineering; Professional Technology Innovation Center of Liaoning Province for Conversion Materials of Solar Cell; Bohai University; Jinzhou 121013; P. R. China Department of Cardiothoracic Surgery, Second Xiangya Hospital, Central South University, Changsha, China. wangxiang@xysm.net Department of Biomedical Sciences, Creighton University, Omaha, NE 68178; and Department of Cardiology, Laiwu People's Hospital, Laiwu, Shandong 271100, P.R. China Department of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, P. R. China China University of Geosciences, Beijing 100083, China. wxcugb@qq.com Department of Chemistry; Queen's University; Kingston; Canada College of Pharmaceutical Science Zhejiang University of Technology Hangzhou P. R. China Digestive Endoscopy Center, The First Affiliated Hospital of Nanjing Medical University and Jiangsu Province Hospital, Nanjing, China Thoracic Oncology Center Division of NanoMedicine, Department of Medicine, ‡California NanoSystems Institute, §Department of Chemistry & Biochemisty, and ⊥Department of Materials Science and Engineering, University of California, Los Angeles, California 90095, United States Cardiovascular Department, Shanghai Xuhui Central Hospital, Fudan University , Shanghai 200031, China Department of Thoracic Surgery, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, P.R. China Department of Chemistry Beijing Normal University Beijing China State Key Laboratory of Physical Chemistry of Solid Surfaces The MOE Key Laboratory of Spectrochemical Analysis & Instrumentation Collaborative Innovation Center of Chemistry for Energy Materials Department of Chemistry College of Chemistry and Chemical Engineering Xiamen University Xiamen 361005 China Chemical Sciences Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831, United States Digestive Endoscopy Center, The First Affiliated Hospital with Nanjing Medical University and Jiangsu Province Hospital, Nanjing, China Department of Advertising Xiamen University Xiamen China Cardiovascular Center the First Hospital of Jilin University Changchun 130021 China CAF; National Engineering Laboratory for Biomass Chemical Utilization, Key and Open Laboratory on Forest Chemical Engineering, SFA, Key Laboratory of Biomass Energy and Material, Institute of Chemical Industry of Forest Products, Nanjing, Jiangsu 210042, China; Department of Chemistry and Chemical Engineering, MOE Engineering Research Center of Forestry Biomass Materials and Bioenergy, Beijing Forestry University, Beijing 100083, China School of Electrical Engineering, Guangxi University, Nanning 530004, China From the Departments of Biochemistry (X.W., F.L.C., S.B.C., J.O., C.F.-P.), Pediatrics (T.O., G.D.L.), Pharmacology (G.D.L.), and Physiology (Z.K.) and the Cardiovascular Research Group (X.W., T.O., F.L.C., S.B.C., J.O., Z.K., G.D.L., C.F.-P.), University of Alberta, Edmonton, Alberta, Canada. Xiangya School of Medicine, Central South University , Changsha , Hunan , China Center of Environmental Implications of Nanotechnology (UC CEIN) California NanoSystems Institute University of California Los Angeles CA 90095 USA; Division of NanoMedicine Department of Medicine University of California Los Angeles CA 90095 USA Department of Breast Surgical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100021, China Department of Thoracic Surgery, Hunan Key Laboratory of Early Diagnosis and Precision Therapy in Lung Cancer, Second Xiangya Hospital, Central South University, Changsha Hunan 410011, China State Key Laboratory of Crop Genetics and Germplasm Enhancement, Nanjing Agricultural University, Nanjing, China Department of Neurosurgery, West China Hospital of Sichuan University, No. 37, Guoxue Alley, Chengdu 610041, China Technical Center for Multifunctional Magneto-Optical Spectroscopy (Shanghai), Engineering Research Center of Nanophotonics Advanced Instrument (Ministry of Education), Department of Physics, School of Physics and Electronic Science, East China Normal University, Shanghai 200241, China Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, Nanjing University of Chinese Medicine , Nanjing, Jiangsu Province, People's Republic of China Division of Microbiology and Immunology,and, Virginia Commonwealth University and McGuire VA Medical Center,Richmond,VA Email: xiangw@vip.sina.com. State Key Laboratory of Physical Chemistry of Solid Surfaces, Collaborative Innovation Center of Chemistry for Energy Materials (iChEM), Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University , Xiamen 361005, China Key Laboratory of Agricultural Environmental Microbiology, Ministry of Agriculture, College of Life Science, Nanjing Agricultural University, Nanjing 210095, PR China School of Materials and Chemistry Institute of Bismuth Science Shanghai Collaborative Innovation Center of Energy Therapy for Tumors University of Shanghai for Science and Technology Shanghai 200093 China College of Pharmaceutical Science; Zhejiang University of Technology; Hangzhou; China State Key Laboratory of Chemical Engineering; Tianjin Key Laboratory of Applied Catalysis Science and Technology; School of Chemical Engineering and Technology; Tianjin University; Tianjin 300072 Department of Pharmacy, Xiangya Hospital, Central South UniversityChangshaP.R. China Department of Chemistry, Queen's University, Kingston, Ontario, K7L 3N6, Canada From the Departments of Biochemistry (J.O., X.W., S.C., C.F.-P.), Pediatrics (T.O., G.L.), Pharmacology (G.L.), Physiology (Z.K.), School of Molecular and Systems Medicine (J.O., X.W., S.C., T.O., G.L., Z.K., C.F.-P.), and the Cardiovascular Research Group (J.O., X.W., S.C., T.O., G.L., Z.K., C.F.-P.), University of Alberta, Edmonton, Alberta, Canada. Department of Neurosurgery and Institute of Neurosurgery, State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu, 610041, PR China State Key Laboratory of Medicinal Chemical Biology, Research Center for Analytical Sciences, and Tianjin Key Laboratory of Biosensing and Molecular Recognition, College of Chemistry, Nankai University, Tianjin 300071, China Department of Radiology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P.R., China Key Laboratory of Agricultural Environmental Microbiology, Ministry of Agriculture, College of Life Sciences, Nanjing Agricultural University, Nanjing, Jiangsu 210095, PR China Department of Oral Medicine, Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, China Department of Vascular Surgery, Shanghai East Hospital Affiliated to Tongji University School of Medicine, Shanghai 200120, P.R. China Shi's Center of Orthopedics and Traumatology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine (TCM), Institute of Traumatology and Orthopedics, Shanghai Academy of TCM, Shanghai 201203, P.R. China Department of Radiology Central Hospital of Wuhan Jiangan District, Wuhan China †Surgery Branch, Division of Clinical Sciences, National Cancer Institutes, National Institutes of Health, Bethesda, MD 20892 School of Nursing, Anhui University of Chinese Medicine Hefei 230012, China. Division of NanoMedicine; Department of Medicine; University of California; Los Angeles California 90095 USA; Center for Environmental Implications of Nanotechnology; California NanoSystems Institute; University of California; Los Angeles California 90095 USA Department of Thoracic Surgery, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China; Hunan Key Laboratory of Early Diagnosis and Precise Treatment of Lung Cancer, the Second Xiangya Hospital of Central South University, Changsha, Hunan, China Department of Urology, Peking University First Hospital, Institute of Urology, Peking University, National Urological Cancer Centre, Beijing, China. School of Nursing Anhui University of Traditional Chinese Medicine Hefei China Academic Support Department Berry Genomics Corporation Beijing China Graduate School of Anhui University of Chinese Medicine, Hefei, Anhui 230012, China School of Chemistry and Chemical Engineering Southwest University Chongqing P. R. China Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310006, P.R. China Medical Psychological Center, The Second Xiangya Hospital, Central South University, Changsha, People’s Republic of China; Medical Psychological Institute of Central South University, Changsha, People’s Republic of China; National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital, Central South University, Changsha, People’s Republic of China State Key Laboratory of Mechanics and Control for Aerospace Structures, Key Laboratory for Intelligent Nano Materials and Devices of the Ministry of Education, Nanjing University of Aeronautics and Astronautics, Nanjing 210016, P. R. China; College of Aerospace Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing 210016, P. R. China Department of Neurosurgery, Sanbo Brain Hospital, Capital Medical University, Beijing, China Department of Otolaryngology Head and Neck Surgery，Taiyuan Central Hospital. Beijing National Laboratory for Condensed Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing 100190, P. R. China; University of Chinese Academy of Sciences, Beijing 100049, P. R. China; Songshan Lake Materials Laboratory, Dongguan, Guangdong 523808, P. R. China Shanghai Public Health Clinical Center, Fudan University, Shanghai, People’s Republic of China School of Chemistry and Chemical Engineering, Harbin Institute of Technology 1 , Harbin 150001, China; Department of Chemistry, Southern University of Science and Technology 2 , Shenzhen 518000, China State Key Laboratory of Crop Genetics and Germplasm Enhancement, Nanjing Agricultural University, Nanjing 210095, China. National Engineering Research Center for Colloidal Materials; School of Chemistry and Chemical Engineering; Shandong University; 250100 Jinan; China Department of Neurosurgery, West China Hospital of Sichuan University, Chengdu610041, China Department of Digestive Endoscopy The First Affiliated Hospital with Nanjing Medical University Nanjing Jiangsu Province China Department of Breast Surgery, Cancer Hospital, Chinese Academy of Medical Sciences, Beijing, People's Republic of China Institute for Integrated Catalysis; Pacific Northwest National Laboratory; Richland; USA Key Laboratory of Agricultural Environmental Microbiology, Ministry of Agriculture, College of Life Sciences, Nanjing Agricultural University, Nanjing 210095, PR China School of Chemistry and Chemical Engineering, Huaiyin Normal University, Huaian 223300, P. R. China Department of Chemistry and Biochemistry, University of Maryland, College Park, Maryland 20742, United States The "111 Project" Laboratory of Biomechanics & Tissue Repair Engineering; Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University College of Nursing, Anhui University of Chinese Medicine, Hefei, China. Department of Occupational and Environmental Health, School of Public Health, Peking University Health Science Center, Beijing 100083, China. P. M. Gross Chemical Laboratory, Duke University, Durham, North Carolina 27708-0346 Key Laboratory of Energy Conversion and Storage of Shanxi Province; Institute of Molecular Science; Shanxi University; Taiyuan; People's Republic of China Department of Mechanical and Aerospace Engineering, University of Texas at Arlington, 500 W. First Street, Woolf Hall 226, Arlington, Texas 76019, United States Institute of Cancer Stem Cell Dalian Medical University Dalian, Liaoning China Department of Radiology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P.R. China College of Chemistry and Chemical Engineering; Professional Technology Innovation Center of Liaoning Province for Conversion Materials of Solar Cell; Bohai University; Jinzhou; P. R. China Department of Gastroenterology, The Second Hospital, Lanzhou University, Gansu Province, Lanzhou 730000, China Key Laboratory of Radiopharmaceuticals, Ministry of Education, Beijing Normal University, Beijing 100875, China Medical Psychological Department of The Second Xiangya Hospital, Central South University, Changsha Hunan, China. wang0916xia@yahoo.com.cn Department of Chemistry and Biochemistry, University of Colorado Boulder, Boulder, Colorado 80309, United States Department of Oncology, Xuzhou Central Hospital, Xuzhou, Jiangsu 221000, P.R. China College of Chemistry and Chemical Engineering Shanghai University of Engineering Science Shanghai 201620 China Department of Gastrointestinal Surgery, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, Hainan 570311, P. R. China Department of Oncology, Taizhou Hospital of Traditional Chinese Medicine, Taizhou, Jiangsu 225300, P.R. China Department of Breast Surgical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China Division of Pediatric Urology, Children's Hospital of Fudan University, Shanghai, China. Department of Vascular Surgery, Taizhou Hospital of Zhejiang Province, Affiliated to Wenzhou Medical University, Linhai, Zhejiang Province, China Department of Medicine, Division of NanoMedicine, ‡UC Center of Environmental Implications of Nanotechnology, §UCLA Center for Nanobiology and Predictive Toxicology, ∥California NanoSystems Institute, University of California, Los Angeles, California 90095, United States Department of Materials Science and Engineering, City University of Hong Kong, Tat Chee Avenue 83, Kowloon, Hong Kong SAR 999077, P. R. China Chemical Process R&D, Amgen Inc., One Amgen Center Drive, Thousand Oaks, California 91320 xiangw@amgen.com Department of Neurosurgery Sanbo Brain Hospital Capital Medical University Beijing China Division of NanoMedicine, Department of Medicine, University of California, Los Angeles, California 90095, United States; California NanoSystems Institute, University of California, Los Angeles, California 90095, United States College of Life Sciences, Liaoning Normal University, Dalian 116029, China. Department of Critical Care Medicine, Sinopharm Dongfeng General Hospital, Hubei University of Medicine, Shiyan, China Shanghai Institute of Occupational Disease for Chemical Industry Shanghai China Department of Abdominal Surgery, Cancer Institute & Hospital, Chinese Academy of Medical Sciences, Beijing 100021, China. Email: xiangw@vip.sina.com. Center for Environmental Implications of Nanotechnology, California NanoSystems Institute, University of California, Los Angeles, California 90095, United States Department of Materials Science and Engineering, City University of Hong Kong, Hong Kong, SAR 999077, P. R. China Key Laboratory of Eutrophication and Red Tide Prevention of Guangdong Higher Education Institutes College of Life Science and Technology Jinan University Guangzhou 510632 P. R. China From the Department of Neurosurgery, Changzheng Hospital, Second Military Medical University, Shanghai, China. Department of Neurosurgery, West China Hospital of Sichuan University, Chengdu, China; State Key Laboratory for Physical Chemistry of Solid Surfaces; The MOE Key Laboratory for Spectrochemical Analysis and Instrumentation; iChEM and Department of Chemistry; College of Chemistry and Chemical Engineering; Xiamen University State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Beijing Key Laboratory of Active Substance Discovery and Drugability Evaluation, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China Chemistry Research and Discovery, Amgen Inc., Thousand Oaks, California 91320-1799 State Key Laboratory of Physical Chemistry of Solid Surface, Collaborative Innovation Center of Chemistry for Energy Materials (iChEM), College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China Department of Otolaryngology Head and Neck Surgery，Shanghai Children's Medical Center Affiliated to Shanghai Jiaotong University. Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland National Marine Environmental Monitoring Center State Key Laboratory of Soil Erosion and Dryland Farming on the Loess Plateau, Institute of Soil and Water Conservation, Northwest A&F University, Yangling 712100, Shaanxi, China. Digestive Endoscopy Center, The First Affiliated Hospital with Nanjing Medical University & Jiangsu Province Hospital, Nanjing, China From the Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 Beijing Laboratory of Food Quality and Safety, College of Engineering, China Agricultural University, Beijing 100083, China Center for Environmental Implications of Nanotechnology California NanoSystems Institute, University of California Los Angeles CA 90095 USA School of Public Health, Guangzhou Medical University, 195 Dongfeng Xi Road, Guangzhou 510182, China Digestive Endoscopy Department Jiangsu Province Hospital and The First Affiliated Hospital with Nanjing Medical University Nanjing China; Department of General Surgery Jiangsu Province Hospital and The First Affiliated Hospital with Nanjing Medical University Nanjing China Department of Abdominal Surgery, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China. Email: xiangw@vip.sina.com. Testing Center of Occupational Health , Shanghai Institute of Occupational Safety and Health, Shanghai 200031, China. Key Laboratory of Environmental Optics and Technology, Anhui Institute of Optics and Fine Mechanics, Chinese Academy of Sciences, Hefei 230031, People's Republic of China; Key Laboratory of Optical Monitoring Technology for Environment, Anhui Province, Hefei 230031, People's Republic of China; University of Science and Technology of China, Hefei 230026, People's Republic of China Department of Digestive Endoscopy The First Affiliated Hospital with Nanjing Medical University Nanjing China Institute of Bismuth Science and School of Materials and Chemistry University of Shanghai for Science and Technology Shanghai 200093 China Department of Obstetrics, Key Laboratory of Birth Defects and Related Disease of Women and Children of MOE, State Key Laboratory of Biotherapy, West China Second Hospital, Sichuan University, Chengdu 610041, Sichuan, China Institute of Chemical Industry of Forest Products, Chinese Academy of Forestry, National Engineering Laboratory for Biomass Chemical Utilization, Key and Open Laboratory on Forest Chemical Engineering, National Forestry and Grassland Administration, Key Laboratory of Biomass Energy and Material, Nanjing, China Physical Department, College of Science Shanghai University Shanghai China State Key Laboratory of Mechanics and Control of Mechanical Structures, Key Laboratory for Intelligent Nano Materials and Devices of the Ministry of Education, Nanjing University of Aeronautics and Astronautics, Nanjing 210016, P. R. China; College of Aerospace Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing 210016, P. R. China 2Department of Radiation Oncology and Kimmel Cancer Center of Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania; Department of Structural Engineering University of California, San Diego La Jolla 92093 CA USA Department of Cell Biology University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States Division of NanoMedicine University of California Los Angeles CA 90095 USA; California NanoSystems Institute University of California Los Angeles CA 90095 USA Department of Chemistry South University of Science and Technology of China Shenzhen P. R. China Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials; Ministry-of-Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules; College of Chemistry and Chemical Engineering; Hubei University; Wuhan 430062 School of Chemical Engineering and Pharmacy, Wuhan Institute of Technology, Wuhan 430205, China; Catalonia Institute for Energy Research (IREC), Sant Adrià de Besòs, 08930 Barcelona, Spain Pediatric Research Institute, Department of Pediatrics, University of Louisville School of Medicine, Louisville, KY 40202, USA; Department of Cardiovascular Disease, First Hospital of Jilin University, Jilin University, Changchun 130021, China Department of Neurosurgery, Sichuan University, West China Hospital, Chengdu, Sichuan, China The State Key Laboratory of Crop Genetics and Germplasm Enhancement, Nanjing Agricultural University, Nanjing 210095, China From the Departments of Biochemistry (X.W., F.L.C., L.H., A.L.-C., S.C., J.O., C.F.-P.), Pediatrics (T.O., R.S., G.D.L.), Pharmacology (R.S., G.D.L.), Anesthesiology and Pain Medicine (B.A.F.), and Physiology (Z.K.) and the Cardiovascular Research Group (X.W., F.L.C., T.O., L.H., A.L.-C., S.K., S.C., J.O., B.A.F., R.S., Z.K., G.D.L., C.F.-P.), University of Alberta, Edmonton, Alberta, Canada. Contribution from the Optical Sciences Division, Code 5611, Center for Bio/Molecular Science and Engineering, Code 6900, Naval Research Laboratory, Washington, D.C. 20375, and Department of Chemistry and Biochemistry, University of Maryland, College Park, Maryland 20742 Dept. of Oral Medicine, School of Stomatology, Jilin University, Changchun 130041, China. Department of Breast Surgical Oncology, Cancer Hospital of Chinese Academy of Medical Sciences, Beijing, China Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine , Hangzhou , China Department of Medicine, Division of NanoMedicine, Center for Environmental Implications of Nanotechnology, California Nanosystems Institute, University of California at Los Angeles, Los Angeles, California, USA Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, Maryland Department of Oral and Maxillofacial Surgery, Nanjing Stomatological Hospital, Medical School of Nanjing University, 210000 Nanjing, Jiangsu, China; Department of Chemistry & Institutes of Biomedical Sciences, Fudan University, Shanghai, China Department of Stomatology, The First People's Hospital of Nantong, Affiliated Hospital 2 of Nantong University, Nantong, Jiangsu 226000, P.R. China Key Laboratory of Eutrophication and Red Tide Prevention of Guangdong Higher Education Institute, College of Life Science and Technology, Jinan University, Guangzhou 510632, China Department of Gastrointestinal Surgery Second Affiliated Hospital and Yuying Children’s Hospital Wenzhou Medical University Wenzhou China CAS Key Laboratory of Molecular Nanostructure and Nanotechnology, CAS Research/Education Center for Excellence in Molecular Sciences, Beijing National Laboratory for Molecular Science (BNLMS), Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China; University of Chinese Academy of Sciences, Beijing 100049, China RIKEN Center for Emergent Matter Science 2-1 Hirosawa Wako Saitama 351-0198 Japan Tsinghua University 1 Department of Engineering Mechanics, AML, , Beijing 100084, China Institute of Fluid Physics Laboratory for Shock Waves and Detonation Physics Research, , P.O. Box 919-102, Mianyang, Sichuan 621900, People's Republic of China Department of Breast Surgery, Cancer Hospital, Chinese Academy of Medical Sciences, Beijing, China Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, P.R. China Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, Sichuan 610000, P.R. China Department of Breast Surgery Cancer Hospital, Chinese Academy of Medical Sciences Beijing China QXP Technology Inc. Medical Psychological Institute of the Second Xiangya Hospital, Central South University, Changsha, China Department of Cardiology, Institute of Cardiovascular Disease, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China Department of Food Science and Technology National University of Singapore 2 Science Drive 2 Singapore 117542 Singapore Digestive Endoscopy Center, The First Affiliated Hospital with Nanjing Medical University, Nanjing, Jiangsu 210029, China Department of Urology Shanghai General Hospital Shanghai Jiaotong University Shanghai China Department of Hematology, Anhui Provincial Hospital Affiliated to Anhui Medical University,Hefei 230000, Anhui Province, China. National Engineering Research Centre for Wheat/Henan Technology Innovation Centre of Wheat, Henan Agricultural University, Zhengzhou 450046, China Department of Chemistry; Bohai University; Jinzhou; P. R. China Department of Urology, China-Japan Friendship Hospital, Beijing 100029, China. Email: wangxiang-uro@hotmail.com. Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan, Hubei 430072, China; Hubei Key Laboratory of Developmentally Originated Disease, College of Life Sciences, Wuhan University, Wuhan, Hubei 430072, China; and Department of Biochemistry and Molecular Biology, College of Life Sciences, Wuhan University, Wuhan, Hubei 430072, China Department of Urology, Shanghai General Hospital California NanoSystems Institute, University of California, 570 Westwood Plaza, Los Angeles, California 90095, United States Digestive Endoscopy Department Jiangsu Province Hospital the First Affiliated Hospital with Nanjing Medical University Nanjing China Nephrology Department, First Affiliated Hospital, Huzhou Teachers College, The First People's Hospital of Huzhou, Huzhou, Zhejiang 313000, P.R. China Zhejiang Provincial Key Laboratory of Media Biology and Pathogenic Control, Central Laboratory, First Affiliated Hospital of Huzhou University, Huzhou, Zhejiang 313000, P.R. China School of Chemistry and Chemical Engineering; Southwest University; Chongqing; P. R. China Center for Translational Medicine, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, P.R. China; Key Laboratory for Tumor Precision Medicine of Shaanxi Province, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, P.R. China Division of Anti-Tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China Obstetrical Department, Jinan Maternal and Child Care Service Centre, Jinan City, Shandong Province, China. Department of Biosynthetic Medicinal Chemistry, School of Pharmacy, Fudan University, Shanghai, PR China Division of Anti‐tumor Pharmacology, Shanghai Institute of Materia Medica Chinese Academy of Sciences Shanghai China Department of Central Laboratory, First Affiliated Hospital of Huzhou University, Huzhou, Zhejiang 313000, P.R. China State Key Laboratory of Biocontrol, Institute of Aquatic Economic Animals, The Guangdong Province Key Laboratory for Aquatic Economic Animals, Sun Yat-Sen University, Guangzhou, China; College of Pharmaceutical Science Zhejiang University of Technology Hangzhou 310032 P. R. China Department of General Surgery, Second Hospital of He Fei Affiliated with Anhui Medical University, Hefei, Anhui, China National Key Laboratory of Crop Genetic Improvement College of Plant Science and Technology Huazhong Agricultural University Wuhan Hubei 430070 China 7Key Laboratory for Translational Medicine, First Affiliated Hospital, Huzhou University, Huzhou, China. Center for Biosystems Research, University of Maryland Biotechnology Institute, College Park, Maryland 20742, and Department of Chemistry and Biochemistry, Department of Chemical and Biomolecular Engineering, and Department of Electrical and Computer Engineering and The Institute for Systems Research, University of Maryland, College Park, Maryland 20742 Division of NanoMedicine, Department of Medicine, and California NanoSystems Institute, University of California, Los Angeles, California 90095, United States School of Materials and Chemistry, Institute of Bismuth, University of Shanghai for Science and Technology, Shanghai 200093, China Department of Biostatistics School of Public Health Nanjing Medical University Nanjing People's Republic of China Soochow University Polymer Science and Engineering 215123 Suzhou CHINA Department of Urology, Peking University First Hospital, Beijing 100034, China; Institute of Urology, Peking University, Beijing 100034, China; National Urological Cancer Center, Beijing 100034, China First Affiliated Hospital, Huzhou University, The First People's Hospital of Huzhou, Huzhou, Zhejiang 313000, P.R. China Medical Psychological Center, The Second Xiangya Hospital, Central South University , Changsha, Hunan 410011, China Key Laboratory of Materials for Energy Conversion and Storage of Shanxi Province, The Key Laboratory of Chemical Biology and Molecular Engineering of Education Ministry Institute of Molecular Science, Shanxi University Taiyuan 030006 People's Republic of China School of Nuclear Science and Engineering, North China Electric Power University, Beijing102206, China School of Medical Instrument and Food Engineering University of Shanghai for Science and Technology Shanghai China Department of Thoracic Surgery, The Second Xiangya Hospital, Central South University , 410078 , Changsha , China Department of Chemistry and Biochemistry, University of Colorado, Boulder, Colorado 80309, United States Center of Clinical Laboratory, The First People's Hospital of Huzhou, Huzhou Teachers College, Huzhou, Zhejiang 313000, P.R. China Authors' Affiliations: 1Dr. Susan Love Research Foundation, Santa Monica; 2Department of Pathology & Laboratory Medicine, University of California—Los Angeles, Los Angeles, California; and 3Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Beijing, China College of Materials Science and Engineering, Sichuan University, Chengdu 610065, China School of Mechanical Engineering Shanghai Jiao Tong University Shanghai China Department of Radiology Wuhan Central Hospital Wuhan China Department of Endocrinology and Metabolism, The First Affiliated Hospital of Zhengzhou University Zhengzhou, China. Department of Biochemistry and Molecular Biology, College of Life Sciences, Wuhan University, Wuhan, Hubei 430072, China; and State Key Laboratory of Fine Chemicals, School of Chemical Engineering Dalian University of Technology Dalian 116024 China Department of Cardiology, Laiwu City People's Hospital, Laiwu, Shandong 27110, P.R. China Acupuncture and Tuina College, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China. Departmnet of rehabilitation, The First Affiliated Hospital of Xi'an Medical University, Xi'an 710077, China. College of Chemistry & Green Catalysis Center Zhengzhou University Zhengzhou 450001 P. R. China Key Laboratory of Eutrophication and Red Tide Prevention of Guangdong Higher Education Institutes, College of Life Science, Jinan University, Guangzhou, China Department of Oncology, Hebei Chest Hospital, Lung Cancer Prevention and Research Center of Hebei Province, Shijiazhuang, Hebei, People's Republic of China Department of Vascular Surgery, Taizhou Hospital, Zhejiang University, China. First People’s Hospital of Huzhou, First Affiliated Hospital of Huzhou University, Huzhou, Zhejiang, China (mainland) Department of Radiation Oncology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, 266003, China Department of Mechanical Engineering, Dongguan University of Technology, Dongguan 523808, China School of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, Shanghai, China. Chinese Academy of Engineering Physics National Key Laboratory of Shock Wave and Detonation Physics, Institute of Fluid Physics, , Mianyang, Sichuan 621900, China Department of Cardiology Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei China Department of Nuclear Science and Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing 211106, China Department of Urology, Huashan Hospital, Fudan University, Shanghai, PR China; Fudan Institute of Urology, Huashan Hospital, Fudan University, Shanghai, PR China Department of Prevention, Tianjin Haihe Hospital, Jinnan, Tianjin 300350, P.R. China School of Chemistry and Chemical Engineering, Huaiyin Normal University, Huaian 223300, People’s Republic of China Department of Breast Surgical Oncology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of China Institute of Fluid Physics Laboratory for Shock Waves and Detonation Physics Research, , P. O. Box 919-102, Mianyang, Sichuan 621900, China National Key Laboratory of Crop Genetic Improvement, College of Plant Science and Technology, Huazhong Agricultural University, Wuhan 430070, China Department of Endocrinology, Affiliated Hospital of Medical College Qingdao University, Qingdao, China Department of Neurosurgery and Institute of Neurosurgery State Key Laboratory of Biotherapy and Cancer Center West China Hospital West China Medical School Sichuan University and Collaborative Innovation Center for Biotherapy Chengdu 610041 China bjczwangxiang@sohu.com Shanghai Kidney Development and Pediatric Kidney Disease Research Center Shanghai China; Department of Urology Children's Hospital of Fudan University Shanghai China National Key Laboratory of Shock Wave and Detonation Physics , Institute of Fluid Physics, CAEP, Mianyang, Sichuan 621900, People's Republic of China Medical Institute of Psychology Second Xiangya Hospital of Central South University Changsha China Peking University People's Hospital Peking University Institute of Hematology National Clinical Research Center for Hematologic Disease Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation Beijing China College of Life Sciences, Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan University, Wuhan, Hubei, 430072 China Beijing National Laboratory for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China Key Laboratory of Agricultural Environmental Microbiology, Ministry of Agriculture, College of Life Sciences, Nanjing Agricultural University, Nanjing, Jiangsu, People's Republic of China; College of Resource and Environment, Anhui Science and Technology University, Anhui, People's Republic of China Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai, China (W.L., X.Z., Z.D., X.W., Z.P., S.S., Y.Z., Z.W., B.Z., L.L., P.B., J.L., X.W., T.G., X.S., H.C., K.H., A.S., J.G.).; Key Laboratory of Viral Heart Diseases, National Health Commission, Shanghai, China (W.L., X.Z., Z.D., X.W., Z.P., S.S., Y.Z., Z.W., B.Z., L.L., P.B., J.L., X.W., T.G., X.S., H.C., K.H., A.S., J.G.).; Key Laboratory of Viral Heart Diseases, Chinese Academy of Medical Sciences, Shanghai, China (W.L., X.Z., Z.D., X.W., Z.P., S.S., Y.Z., Z.W., B.Z., L.L., P.B., J.L., X.W., T.G., X.S., H.C., K.H., A.S., J.G.). Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China Key Laboratory of Digestive Disease, Gansu Province, Lanzhou University Second Hospital, Lanzhou, China Department of Occupational and Environmental Health, School of Public Health, Peking University, Beijing 100083, China, Laboratory for Bio-Environmental Health Sciences of Nanoscale Materials, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China, and College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China Department of Radiology, The Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University, Changzhou, Jiangsu 213164, P.R. China State Key Laboratory for Physical Chemistry of Solid Surfaces Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province (IKKEM) Collaborative Innovation Center of Chemistry for Energy Materials (iChEM) Engineering Research Center of Electrochemical Technologies of Ministry of Education Department of Chemistry College of Chemistry and Chemical Engineering Xiamen University Xiamen Fujian 361005 China School of Integrated Chinese and Western Medicine, Anhui University of Chinese Medicine, Hefei 230012, China Department of Chemistry Queen's University 90 Bader Lane Kingston Ontario K7L 3N6 Canada Department of Nephrology and Rheumatology, Wuhan Children's Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan , China; Clinical Genetic Center, Children's Hospital of Fudan University, National Children's Medical Center , Shanghai , China College of Chemistry; Chemical Engineering and Materials Science; Soochow University; Suzhou; China Department of Cardiology Beijing Hospital National Center of Gerontology Institute of Geriatric Medicine Chinese Academy of Medical Sciences Beijing China; Graduate School of Peking Union Medical College Chinese Academy of Medical Sciences Beijing China Department of Oral Medicine & Oral Pathology, Institute and Hospital of Stomatology, Nanjing University Medical School Nanjing 210008, China ; Jiangsu Key Laboratory of Molecular Medicine, Medical School and State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University Nanjing 210093, China. Department of Stomatology The First People's Hospital of Nantong The Second Affiliated Hospital of Nantong University Nantong China Biology Institute of Shanxi, Taiyuan 030006, China. Medical Psychological Center, The Second Xiangya Hospital, Central South University, Changsha, P. R. China. Chemical Biology Program, and Center for Laboratory Medicine, First Affiliated Hospital of Xi'an Jiaotong University College of Medicine, Xi'an 710061, China. wx6212@yahoo.cn Department of Forensic Medicine, College of Preclinical Medicine, Central South University, Changsha 410013, China. wangx6281@163.com Department of Cardiovascular Disease, First Hospital of Jilin University Jilin University Changchun Jilin China; Department of Pediatrics, Pediatric Research Institute University of Louisville School of Medicine Louisville Kentucky USA Department of Pathophysiology, Institute of Basic Medical Science, Xi’an Medical University, Xi’an, China Department of Metabolic Control and Aging, Human Aging Research Institute and School of Life Science Nanchang University and Jiangxi Key Laboratory of Human Aging Nanchang China 7Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, Hunan, China. Center of Environmental Implications of Nanotechnology (UC CEIN) California Nanosystems Institute University of California Los Angeles CA 90095 USA; Division of Nanomedicine, Department of Medicine University of California Los Angeles CA 90095 USA Department of Nuclear Science and Technology; Nanjing University of Aeronautics and Astronautics; Nanjing 211106; China Hunan Province Key Laboratory of Plant Functional Genomics and Developmental Regulation, College of Biology, Hunan University, Changsha 410082, Hunan, P. R. China. Tel: +08673188664048 Department of Intensive Care Unit, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu Province, China Key Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM); Jiangsu National Synergistic Innovation Center for Advanced Materials (SICAM); Nanjing Tech University (NanjingTech); Nanjing 211816; China Jiangsu Key Laboratory for Chemistry of Low-Dimensional Materials, School of Chemistry and Chemical Engineering, Huaiyin Normal University, Huaian 223300, China California NanoSystems Institute Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400030, P.R. China. National Key Laboratory for Shock Wave and Detonation Physics, Institute of Fluid Physics, China Academy of Engineering Physics, Mianyang, Sichuan 621900, China Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital and Institute of Biomedical Sciences, Fudan University, Shanghai 200032, China Departments of Chemistry and Biochemistry & Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 Department of Radiology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430014, P.R. China Department of Breast Surgery, Cancer Hospital, Chinese Academy of Medical Sciences Department of Hematology, Kaifeng Children’s Hospital, Kaifeng, Henan, China Department of Pediatric Urology, Children’s Hospital of Fudan University, Shanghai Medical Psychological Center, The Second Xiangya Hospital Central South University Changsha Hunan China; China National Clinical Research Center on Mental Disorders (Xiangya) Changsha Hunan China Department of Chemistry, Columbia University, 3000 Broadway, New York, New York 10027 Huzhou Central Hospital, Huzhou, Zhejiang 313000, China Institute of Bismuth Science & School of Materials and Chemistry, University of Shanghai for Science and Technology, 516 Jungong Rd., Shanghai 200093, China Department of Urology, Huashan Hospital Affiliated to Fudan University, Shanghai 200040, China. seanw@medmail.com.cn Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, Jiangsu Province, China The Hunan Institute of Pharmacy Practice and Clinical Research, Xiangya Hospital, Central South University, Changsha 410008, China; Department of Pharmacy, Xiangya Hospital, Central South University, Changsha 410008, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410008, China Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai 200080 , China Division of NanoMedicine, Department of Medicine, ‡California NanoSystems Institute, and §Department of Chemistry, University of California, Los Angeles, California 90095, United States Department of Traumatic Surgery, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology, Wuhan 430030, China. Department of Thoracic Surgery The Second Xiangya Hospital Central South University Changsha Hunan 410011 China; Hunan Key Laboratory of Early Diagnosis and Precise Treatment of Lung Cancer the Second Xiangya Hospital of Central South University Changsha Hunan 410011 China Department of Chemistry and Biochemistry, Queens College, Flushing, New York 11367, United States; The Graduate Center of CUNY, New York, New York 10016, United States College of Computer, National University of Defense Technology, Changsha 410073, China Department of Radiology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430014, China Chemical Process R&D, Amgen Inc., One Amgen Center Drive, Thousand Oaks, California 91320, United States Department of Thoracic Surgery, Xuzhou Central Hospital Affiliated to Southeast University, Xuzhou, China. Catalonia Institute for Energy Research (IREC), Sant Adrià de Besòs, Barcelona 08930, Spain; Departament d’Enginyeria Electrònica i Biomèdica, Universitat de Barcelona, Barcelona, Catalonia 08028, Spain Department of Neurosurgery, Changzheng Hospital, The Second Military Medical University, Shanghai, China NanoScience and NanoTechnology Program and ‡Department of Physics, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong Division of NanoMedicine, Department of Medicine, ‡Department of Chemistry & Biochemistry, and §California NanoSystems Institute, University of California, Los Angeles Ningde Amperex Technology Limited (ATL) Key Laboratory of Consumer Lithium-Ion Battery in Fujian Fujian 352100 China Departments of Chemical and Biomolecular Engineering, and Chemistry and Biochemistry, University of Maryland, College Park, Maryland 20742-2111 State Key Laboratory of Physical Chemistry of Solid Surface; Collaborative Innovation Center of Chemistry for Energy Materials (iChEM); Key Laboratory of Analytical Sciences; Department of Chemistry; College of Chemistry and Chemical Engineering Key Laboratory of Arable Land Conservation (North China) , Department of Soil and Water Science, , Beijing 100193 , China; College of Land Science and Technology, China Agricultural University , Department of Soil and Water Science, , Beijing 100193 , China Shanghai Institute of Cardiovascular Diseases Zhongshan Hospital and Institute of Biomedical Sciences Fudan University Shanghai China Institute of Traditional Chinese Medicine Tianjin University of Traditional Chinese Medicine Tianjin People's Republic of China; Laboratory of Pharmacology of TCM Formulae Co‐Constructed by the Province‐Ministry Tianjin University of Traditional Chinese Medicine Tianjin People's Republic of China; Tianjin State Key Laboratory of Modern Chinese Medicine Tianjin University of Traditional Chinese Medicine Tianjin People's Republic of China Department of Thoracic Surgery, The Second Xiangya Hospital, Central South University, Changsha 410011, China Medical Psychological Institution of Second Xiangya Hospital Central South University Changsha China Department of Endocrinology, The Affiliated Xi’an Central Hospital of Xi’an Jiaotong University School of Life and Health Science, Kaili University, Kaili, Guizhou 556011, China Department of Obstetrics/Gynecology Key Laboratory of Obstetric Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University Chengdu China Department of Radiology The Fourth Affiliated Hospital of China Medical University Shenyang Liaoning China Institute of Advanced Materials (IAM); Nanjing Tech University (Nanjing Tech); Nanjing 211816; China Department of Gastrointestinal Surgery The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University Zhejiang China Institute of Biology and Medical Sciences, Soochow University, Suzhou 215123, Jiangsu Province, China; Vaccine Research Center, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai 200031, China Department of Surgery, First People’s Hospital Affiliated Huzhou University Huzhou China Physical Examination Centre, The Third Affiliated Hospital of Chongqing Medical University Chongqing 401120, China. National Engineering Research Center for Colloidal Materials, Shandong University, Jinan 250100, P. R. China School of Chemistry and Materials Engineering, Kaili University School of Pharmacy, Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica Nanjing University of Chinese Medicine Nanjing China Department of Geriatrics, Peking University First Hospital, Beijing 100034, P.R. China Beijing National Laboratory for Molecular Sciences, Key Laboratory of Analytical Chemistry for Living Biosystems, Institute of Chemistry, The Chinese Academy of Sciences, Beijing 100190, China Department of Neurosurgery, Shunde Hospital of Southern Medical University (The First People’s Hospital of Shunde Foshan), Foshan, Guangdong, China State Key Laboratory of Physical Chemistry of Solid Surfaces, Collaborative Innovation Center of Chemistry for Energy Materials (i-ChEM), Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province (IKKEM), Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China Vaccine Research Center, CAS Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, People’s Republic of China Division of NanoMedicine, Department of Medicine, ‡Department of Chemistry & Biochemistry, §Department of Microbiology, Immunology, and Molecular Genetics, and ⊥California NanoSystems Institute, University of California, Los Angeles, California 90095, United States Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, China School of Biosciences & Institute of Microbiology and Infection (IMI) & Centre for Computational Biology (CCB) University of Birmingham, Edgbaston Birmingham B15 2TT UK State Key Laboratory of Bioactive Substances and Function of Natural Medicine, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China Department of Nuclear Science and Engineering; Nanjing University of Aeronautics and Astronautics; Nanjing; China Key Laboratory of Translational Medicine, First Affiliated Hospital, Huzhou University, 313000 Huzhou, Zhejiang, China; Department of Digestive Endoscopy Center, First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China Department of Quantitative and Computational Biology, Baylor College of Medicine, Houston, TX 77030, USA Departments of Chemistry and Biochemistry and Chemical & Biomolecular Engineering, University of Maryland, College Park, Maryland 20742-2111 Guangdong Provincial Engineering and Technological Research Center for Drug Carrier Development; Department of Biomedical Engineering; Jinan University; Guangzhou 510632; China Center for Environmental Implications of Nanotechnology, California NanoSystems Institute, ‡Department of Molecular, Cell and Developmental Biology, §Division of NanoMedicine, Department of Medicine, ∥Department of Materials Science and Engineering, ⊥Brain Research Institute, and ⊗Department of Chemistry and Biochemistry, University of California, Los Angeles, California 90095, United States Institute of Pediatrics Children’s Hospital of Fudan University National Children’s Medical Center, and the Shanghai Key Laboratory of Medical Epigenetics International Co‐laboratory of Medical Epigenetics and Metabolism, Ministry of Science and Technology Institutes of Biomedical Sciences Fudan University Shanghai China; National Health Commission (NHC) Key Laboratory of Neonatal Diseases Fudan University Shanghai China School of Chemistry and Chemical Engineering, Key Laboratory of Surface & Interface Science of Polymer Materials of Zhejiang Province, Zhejiang Sci-Tech University, Hangzhou 310018, China Department of Neurosurgery, West China Hospital of Sichuan University, Chengdu 610041, China Department of Radiology, Changzheng Hospital, Second Military Medical University, Shanghai, China Division of NanoMedicine Department of Medicine University of California Los Angeles CA 90095 USA; California NanoSystems Institute University of California Los Angeles CA 90095 USA Digestive Endoscopy Department and General Surgery Department, The First Affiliated Hospital with Nanjing Medical University and Jiangsu Province Hospital, Nanjing, Jiangsu 210029, P.R. China Department of Radiology, Wuhan Children's Hospital, Wuhan, China. College of Chemistry and Materials Engineering, Bohai University, Jinzhou, 121013, P. R. China College of Land Science and Technology, Key Laboratory of Arable Land Conservation (North China), Ministry of Agriculture, China Agricultural University, Beijing100193, China Key Laboratory of Eutrophication and Red Tide Prevention of Guangdong Higher Education Institutes, College of Life Science and Technology, Jinan University, Guangzhou 510632, China; Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), Guangzhou 510000, China Department of Biliary II, Shanghai Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438, P.R. China Department of Hematology/Oncology, Shanghai Children's Medical Center Shanghai Jiao Tong University School of Medicine, Key Lab of Pediatric Hematology & Oncology of China Ministry of Health Shanghai China QXP Technology Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, Hunan, China; Institute for Rational and Safe Medication Practices, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China Authors' Affiliations: 1Department of Medical Molecular Biology, Beijing Institute of Biotechnology; 2Center of Computational Biology, Beijing Institute of Basic Medical Sciences; 3Department of Pathology, Chinese PLA General Hospital; 4Department of Biochemistry and Molecular Biology, Beijing Institute of Radiation Medicine, Beijing, China; 5Department of Radiation Oncology, Emory University School of Medicine, Winship Cancer Institute of Emory University; 6School of Biology, Georgia Institute of Technology, Atlanta, Georgia; 7Department of Cancer Biology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania; and 8Genome Institute, National Center for Genetic Engineering and Biotechnology, Pathumthani, Thailand University of Shanghai for Science and Technology, Shanghai, China. State Key Laboratory of Physical Chemistry of Solid Surfaces and College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, 361005, China Department of Materials Science and Engineering College of Chemistry and Materials Science Jinan University Guangzhou 511443 P. R. China Biomedical Sciences, Department of Vascular Surgery, Tongji University Affiliated East Hospital, Shanghai, China Jiangsu Key Laboratory for Chemistry of Low-Dimensional Materials, School of Chemistry and Chemical Engineering, Huaiyin Normal University Department of Breast Surgery Chinese Academy of Medical Sciences and Peking Union of Medical College, Beijing, People's Republic of China; Department of Microbiology and Immunology,Medical College of Virginia Campus, Virginia Commonwealth University,Richmond,VA State Key Laboratory of Physical Chemistry of Solid Surfaces, MOE Key Laboratory of Spectrochemical Analysis and Instrumentation, Collaborative Innovation Center of Chemistry for Energy Materials, and Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China, Department of Cardiovascular Disease Center, The First Hospital of Jilin University, Jilin University, Jilin, People’s Republic of China Fudan Institute of Urology; Huashan Hospital; Fudan University; Shanghai PR China State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Beijing Key Laboratory of Active Substance Discovery and Drug Ability Evaluation, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China Medical Psychological Center the Second Xiangya Hospital, Central South University Changsha Hunan China; Medical Psychological Institute of Central South University Changsha Hunan China; National Clinical Research Center for Mental Disorders Changsha Hunan China Department of Pharmacy, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China Department of Chemistry, Queen’s University, Kingston, Ontario K7L3N6, Canada Surgery Branch, National Cancer Institute, National Institutes of Health, Building 10/2B42, 9000 Rockville Pike, Bethesda, MD 20892, USA. Radiology Department The Affiliated Changzhou No.2 People's Hospital of Nanjing Medical University Changzhou Jiangsu P. R. China Nanjing Stomatological Hospital, Affiliated Hospital of Medical School Nanjing University Nanjing 210008 China Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, PR China Department of Oncology, Xuzhou Central Hospital, Xuzhou Medical University, Xuzhou, China Second Affiliated Hospital of Naval Medical University Department of Radiology Shanghai China Department of Urology, Huashan Hospital of Fudan University National Engineering Research Center for Biomaterials Sichuan University Chengdu Sichuan 610064 P. R. China College of Land Science and Technology China Agricultural University Beijing 100193 China Department of Breast Surgery, Cancer Hospital Chinese Academy of Medical Sciences Beijing People's Republic of China Department of Medical Oncology Peking Union Medical College Hospital Beijing China Department of Surgery, First Affiliated Hospital, Huzhou University, The First People's Hospital of Huzhou, Huzhou, 313000, China State Key Laboratory of Bioactive Substances and Function of Natural Medicine Beijing Key Laboratory of Active Substances Discovery and Drugability Evaluation Institute of Materia Medica Chinese Academy of Medical Sciences & Peking Union Medical College Beijing 100050 China Department of Chemistry, Columbia University, 3000 Broadway, New York, New York, 10027 sames@chem.columbia.edu Hunan Key Laboratory of Early Diagnosis and Precise Treatment of Lung Cancer The Second Xiangya Hospital of Central South University Changsha China; Department of Thoracic Surgery The Second Xiangya Hospital of Central South University Changsha China; Early‐Stage Lung Cancer Center The Second Xiangya Hospital of Central South University Changsha China State Key Laboratory of Physical Chemistry of Solid Surfaces, Collaborative Innovation Center of Chemistry for Energy Materials (i-ChEM), Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China Department of Radiology Central Hospital of Wuhan Tongji Medical College Huazhong University of Science and Technology Wuhan China Department of Chemistry and Center for Streamlined Synthesis, Boston University, 590 Commonwealth Avenue, Boston, Massachusetts 02215 porco@chem.bu.edu Department of Cardiology, First People’s Hospital of Chenzhou, University of South China, Chenzhou 423000, China School of Pharmacy Hunan University of Chinese Medicine Changsha China Department of Chemistry; Queen's University, Kingston; Ontario; Canada Department of Neurology, Shandong Provincial Hospital Shandong University Jinan People's Republic of China; Department of Neurology Shandong Provincial Hospital Affiliated to Shandong First Medical University Jinan People's Republic of China; Shandong Provincial Clinical Research Center for Neurological Diseases Jinan People's Republic of China Department of Obstetrics/Gynecology, Key Laboratory of Obstetric, Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, China Collaborative Innovation Center for Exploration of Hidden Nonferrous Metal Deposits and Development of New Materials in Guangxi, Key Laboratory of Nonferrous Materials and New Processing Technology, Ministry of Education, School of Materials Science and Engineering, Guilin University of Technology, Guilin 541004, China Department of Chemistry and Biochemistry, University of Maryland, College Park, MD 20742; and College of Engineering, China Agricultural University, Beijing 100083, China School of Electronic and Information Engineering, Beihang University, Beijing, China, 100191, and Department of Biomedical Engineering, College of Engineering, Yan Nan Yuan 60, Peking University, Beijing, China, 100871 Department of Cardiology, Jiujiang No. 1 People’s Hospital , Jiujiang, Jiangxi , China Department of Anesthesiology, Wuhan Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei, China. Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University Chongqing China Department of Sleep Medicine, The Fourth People’s Hospital of Lianyungang, Lianyungang, China Institute of Fluid Physics National Key Laboratory of Shock Wave and Detonation Physics, , Mianyang, Sichuan 621900, China Institute for Rational and Safe Medication Practices National Clinical Research Center for Geriatric Disorders Xiangya Hospital Central South University Changsha China; Department of Pharmacy Xiangya Hospital Central South University Changsha China Institute of Manned Space System Engineering, China Academy of Space Technology, Beijing, China. Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Human Anatomy, Histology and Embryology, and State Key Laboratory of Natural and Biomimetic Drugs, Peking University Health Science Center, Beijing, China 1 Department of Hematology/Oncology, National Health Committee Key Laboratory of Pediatric Hematology & Oncology, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, P. R. China; Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, P. R. China California NanoSystems Institute, University of California Los Angeles, 570 Westwood Plaza, Los Angeles, California 90095, United States 1Institute of Cancer, Xinqiao Hospital, Third Military Medical University, Chongqing, China.; 2Clinical Medicine Research Center, Xinqiao Hospital, Third Military Medical University, Chongqing, China. Key Laboratory of Fertility Preservation and Maintenance of Ministry of Education Ningxia Medical University Yinchuan China University of Bergen Department of Biomedicine, , Jonas Lies vei 91, N-5009 Bergen, Norway Department of Medical Oncology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences Beijing 100032, China. Department of Chemistry University of North Carolina at Chapel Hill Chapel Hill NC 27599‐3290 USA State Key Laboratory of Fine Chemicals PSU-DUT Joint Center for Energy Research School of Chemical Engineering Dalian University of Technology Dalian 116024 China School of Environment and Chemical Engineering, Tianjin Polytechnic University, Tianjin, P.R. China Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, China; State Key Laboratory of Fine Chemicals Frontiers Science Center for Smart Materials School of Chemical Engineering Dalian University of Technology Dalian 116024 China School of Advanced Technology, Xi’an Jiaotong-Liverpool University, Suzhou 215123, China Shanghai Key Laboratory of Orthopaedic Implants Department of Orthopaedic Surgery Shanghai Ninth People's Hospital Shanghai JiaoTong University School of Medicine Shanghai China Catalonia Institute for Energy Research (IREC), Sant Adrià de Besòs, 08930 Barcelona, Spain; Departament d’Enginyeria Electrònica i Biomèdica, Universitat de Barcelona, Catalonia, 08028 Barcelona, Spain MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China Department of Geriatric Medicine Osaka University Graduate School of Medicine Suita Japan Department of Chemistry and Biochemistry, University of Colorado, Boulder, CO 80309 College of Chemistry; Chemical Engineering and Environmental Engineering; Liaoning Shihua University; Liaoning; PR China 113001 State Key Laboratory for Modification of Chemical Fibers and Polymer Materials & College of Materials Science and Engineering, Donghua University, Shanghai 201620, China Vaccine Research Center, Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Science, Shanghai, China; Institute of Biology and Medical Sciences, Soochow University, Suzhou, China Department of Orthopaedics, The Sixth Affiliated Hospital of Shanghai, Jiaotong University School of Medicine, 600 Yishan Road, Shanghai, P.R. China. Department of Pathology, The Third Xiangya Hospital of Central South University , Changsha , Hunan, 410013 , China; Xiangya School of Medicine, Central South University , Changsha , Hunan , China Department of Digestive Endoscopy and Medical Center for Digestive Diseases Second Affiliated Hospital of Nanjing Medical University Nanjing China Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, China (mainland) Technical Center for Multifunctional Magneto‐Optical Spectroscopy (Shanghai) Department of Electronic Engineering East China Normal University Shanghai 200241 China Shanghai Key Laboratory of Orthopaedic Implants, Department of Orthopaedic Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, P. R. China Department of Ultrasound, Daping Hospital, Third Military Medical University, Chongqing 400042, China Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, Hunan, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China College of Environment & Safety Engineering, Fuzhou University, Fuzhou, Fujian, People’s Republic of China Department of Cardiothoracic Surgery, Second Xiangya Hospital of Central South University, Changsha, Hunan, China; Key Laboratory of Carcinogenesis and Cancer Invasion, Cancer Research Institute, Xiangya School of Medicine, Central South University, Changsha, Hunan, China Department of Neurology, Shandong Provincial Hospital, Jinan, Shandong, P.R. China Division of Radiation and Cancer Biology, Department of Radiation Oncology, University of Michigan, Ann Arbor, United States Division of NanoMedicine California NanoSystems Institute University of California, Los Angeles Los Angeles CA 90095 USA Natural Products Research Laboratories, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina 27599 Department of Neurology Shandong Provincial Hospital Affiliated to Shandong University Jinan China Institute of Fluid Physics, China Academy of Engineering Physics, Mianyang 621900, China; National Key Laboratory of Shock Wave and Detonation Physics, Institute of Fluid Physics, China Academy of Engineering Physics, Mianyang 621900, China Department of Psychiatry The Second Xiangya Hospital of Central South University Changsha Hunan China Center of Smart Interfaces, Technical University Darmstadt, 64287 Darmstadt, Germany Division of Nanomedicine Department of Medicine University of California Los Angeles CA 90095 USA School of Acupuncture and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China Department of Burns and Plastic Surgery, The First Hospital of Jilin University, Changchun, PR China 6Lanzhou University Second Hospital, Chengguan District, Lanzhou, Gansu, China. College of Land Science and Technology, China Agricultural University, Beijing, China Department of Breast Surgery, Cancer Hospital, Chinese Academy of Medical Sciences, Beijing, 100021, China Key Lab of Organic Optoelectronics and Molecular Engineering of Ministry of Education Department of Chemistry Tsinghua University Beijing 100084 P. R. China Department of Pharmaceutics, CPLA No. 98 Hospital, Huzhou, People’s Republic of China, and Vaccine Research Center, Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Science, Shanghai, China Center for Environmental Implications of Nanotechnology, California NanoSystems Institute University of California at Los Angeles Los Angeles CA 90095 USA Department of Urology, Huashan Hospital of Fudan University, Shanghai 200040, China.seanw@medmail.com.cn. School of Chemistry and Chemical Engineering Southwest University P. R. China Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China College of Land Science and Technology; China University of Geosciences, Beijing; Beijing 100083; China Hunan Key Laboratory of Early Diagnosis and Precise Treatment of Lung Cancer, The Second Xiangya Hospital of Central South University, Central South University, Changsha, Hunan, China; Department of Thoracic Surgery, The Second Xiangya Hospital of Central South University, Central South University, Changsha, Hunan, China State Key Laboratory of Chemical Engineering (Tianjin University); Tianjin Key Laboratory of Applied Catalysis Science and Technology; School of Chemical Engineering and Technology; Tianjin University; Tianjin 300072 Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, China Department of Biosynthetic Medicinal Chemistry, School of Pharmacy, Fudan University Institute of Fluid Physics China Academy of Engineering Physics Mianyang 621900 China Jinan Second Maternal and Child Health Hospital, Jinan, Shandong, China Chemical Process Research and Development, Amgen Inc., One Amgen Center Drive, Thousand Oaks, California 91320, United States School of Public Health Sun Yat‐sen University Guangzhou China Laboratory for Shock Wave and Detonation Physics, Institute of Fluid Physics, China Academy of Engineering Physics 1 , Mianyang, Sichuan 621900, China State Key Laboratory of Fine Chemicals, School of Chemical Engineering, and ⊥School of Life Science and Biotechnology, Dalian University of Technology, 2 Linggong Road, 116024 Dalian, China; Division of NanoMedicine, Department of Medicine, §California NanoSystems Institute, and ∥Department of Ecology and Evolutionary Biology, University of California, Los Angeles, California 90095, United States Department of Radiation Oncology, Kimmel Cancer Center of Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA Joint Laboratory of Reproductive Medicine, SCU-CUHK, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, P.R. China; Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, P.R. China Department of Cardiovascular Disease Center, First Hospital of Jilin University, Jilin University, Jilin, China College of Chemical Engineering, State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, Xinmofanmalu 30, Nanjing 210009, China National and Local Joint Engineering Research Center of Biomedical Functional Materials, Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, School of Chemistry and Materials Science, Nanjing Normal University, 210023 Nanjing, China; Nanjing Stomatological Hospital & State Key Laboratory of Analytical Chemistry for Life Science Medical School Nanjing University Nanjing China IBM T. J. Watson Research Center, Yorktown Heights, NY. Department of Mechanical and Electrical Engineering, Xiamen University, Xiamen 361005, China Department of Radiology, Changzheng Hospital, Navy Medical University, Huangpu District, Shanghai, PR China Department of Urology, China-Japan Friendship Hospital, Beijing 100029, China. wangxiang-uro@hotmail.com The Affiliated Changzhou No. 2 People’s Hospital of Nanjing Medical University, Changzhou, People’s Republic of China Department of Thoracic Surgery, Sichuan Cancer Hospital, Chengdu 610041, China. Guizhou Provincial Key Laboratory of Coal Clean Utilization, School of Chemistry and Materials Engineering, Liupanshui Normal University, Liupanshui 553004, China Department of Medical Oncology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, People's Republic of China Trauma Center/Department of Emergency and Traumatic Surgery, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China Second Department of Biliary Surgery Eastern Hepatobiliary Surgery Hospital Second Military Medical University Shanghai China Department of Radiation Oncology, Emory University School of Medicine and Winship Cancer Institute , Atlanta, GA 30322, USA National Center for Magnetic Resonance in Wuhan; State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics; Wuhan Institute of Physics and Mathematics; Innovation Academy for Precision Measurement Science and Technology; Chinese Academy of Sciences Metabolic Control and Aging—Jiangxi Key Laboratory of Human Aging, Human Aging Research Institute (HARI), School of Life Science, Nanchang University, Nanchang 330031, China Department of Spine Surgery The Affiliated Jiangning Hospital of Nanjing Medical University Nanjing China Key Laboratory of Arable Land Conservation (North China), College of Land Science and Technology, China Agricultural University, Beijing 100193, People’s Republic of China Department of Neurosurgery, West China Hospital of Sichuan University, Chengdu 610041, China. Department of Pharmacy, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China Department of Oral and Maxillofacial Surgery, School of Stomatology, Wuhan University, Wuhan 430079, China. Division of NanoMedicine, Department of Medicine The Center for Applied Genomics Children's Hospital of Philadelphia Philadelphia Pennsylvania USA Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China National Center for Magnetic Resonance in Wuhan, State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Institute of Physics and Mathematics, Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences, Wuhan 430071, China; University of Chinese Academy of Sciences, Beijing 100049, China Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China; Institute for Rational and Safe Medication Practices, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China Professional Technology Innovation Center of Liaoning Province for Conversion Materials of Solar Cell, College of Chemistry and Materials Engineering, Bohai University, Jinzhou, 121000, P. R. China Department of Neurology, Guangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524001,China Medical Psychological Institute, Second Xiangya Hospital of Central South University, P.R. China First Affiliated Hospital, Huzhou Teachers College, The First People's Hospital of Huzhou Huzhou 313000, China. Key Laboratory of Carcinogenesis and Translational Research, Ministry of Education, Peking University Health Science Center, Beijing, China;; State Key Laboratory of Natural and Biomimetic Drugs, Peking University Health Science Center, Beijing, China;; Laboratory of Molecular Cell Biology and Tumor Biology, Department of Anatomy, Histology, and Embryology, Peking University Health Science Center, Beijing, China; and Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, and Howard Hughes Medical Institute, Chemical Biology Program, Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142 Digestive Endoscopy Department, The First Affiliated Hospital with Nanjing Medical University, China Surgery Branch, Division of Clinical Sciences, and College of Resource and Environment, Anhui Science and Technology University, Anhui 233100, PR China Nursing College, Anhui University of Chinese Medicine, Hefei, China. National Engineering Laboratory for Coal-Fired Pollutants Emission Reduction, Shandong University, Jinan, Shandong, People’s Republic of China Chinese Academy of Sciences; University of Chinese Academy of Sciences Department of Neurosurgery and West China Glioma Center West China Hospital, Sichuan University Chengdu China Department of Urology, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China Clinical Medicine Research Center, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China.; Institute of Cancer, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China. National Key Lab of Crop Genetic Improvement, Huazhong Agricultural University, Wuhan, PR China; College of Plant Science and Technology, Huazhong Agricultural University, Wuhan, PR China State Key Laboratory of Bioactive Substances and Function of Natural Medicine; Beijing Key Laboratory of Active Substances Discovery and Drugability Evaluation; Institute of Materia Medica; Peking Union Medical College and Chinese Academy of Medical Sciences; Beijing Division of Anti-Tumor Pharmacology Department of Thoracic Surgery, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Cancer Hospital Affiliated to School of Medicine, UESTC, Chengdu 610000, China First Affiliated Hospital of Xi'an Medical University. School of Mathematics and Physics, China University of Geosciences , Wuhan 430074, China College of Chemistry and Chemical Engineering Southwest University No.2 Tiansheng Road Beibei District, Chongqing P. R. China College of Resource and Environment, Anhui Science and Technology University, Anhui, China Surgical Neurology Branch, National Institute of Neurologic Diseases and Stroke, Bethesda, Maryland 20892 Department of Clinical Medicine; School of Medicine; Nankai University; Tianjin 300071; China Institute of Fluid Physics Laboratory for Shock Waves and Detonation Physics Research, , P.O. Box 919-102, Mianyang, Sichuan 621900, China School of Chemistry and Chemical Engineering, Xuzhou Normal University, Xuzhou, 221116, Jiangsu, P. R. China 1 Beijing Institute of Biotechnology, Beijing 100850, China, 2 Department of Radiation Oncology, Winship Cancer Institute, Emory University, Atlanta, GA 30322, USA, 3 Department of Radiation Oncology, Thomas Jefferson University, Philadelphia, PA 19107 and 4 Department of Internal Medicine, Kidney Institute & Division of Nephrology, University of Kansas Medical Center, Kansas City, KS 66160, USA State Key Laboratory of Physical Chemistry of Solid Surfaces, Collaborative Innovation Center of Chemistry for Energy Materials (iChEM), College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China Department of Medical Oncology National Cancer Center/National Clinical Research Center for Cancer/National Clinical Research Center for Anticancer Drug/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China State Key Laboratory of Physical Chemistry of Solid Surface, The MOE Key Laboratory of Spectrochemical Analysis and Instrumentation, Collaborative Innovation Center of Chemistry for Energy Materials (iChEM), College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China Catalonia Institute for Energy Research - IREC, Sant Adrià de Besòs, Barcelona, Catalonia 08930, Spain Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, Washington 99352, United States Key Laboratory of Agricultural Environmental Microbiology, Ministry of Agriculture, College of Life Sciences, Nanjing Agricultural University, Nanjing, 210095, PR China State Key Laboratory for Mechanical Behavior of Materials, Xi'an Jiaotong University, Xi'an, China. Department of Cell Biology, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States Department of Biomedicine, University of Bergen, 5009 Bergen, Norway CAS Key Laboratory of Molecular Nanostructure and Nanotechnology CAS Research/Education Center for Excellence in Molecular Sciences Beijing National Laboratory for Molecular Science (BNLMS) Institute of Chemistry Chinese Academy of Sciences Beijing 100190 China; University of Chinese Academy of Sciences Beijing 100049 China State Key Laboratory of Physical Chemistry of Solid Surfaces, ‡The MOE Key Laboratory of Spectrochemical Analysis and Instrumentation, and §Collaborative Innovation Center of Chemistry for Energy Materials, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China State Key Laboratory of Physical Chemistry of Solid Surfaces, Collaborative Innovation Center of Chemistry for Energy Materials (iChEM), The MOE Key Laboratory of Spectrochemical Analysis & Instrumentation, and Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China College of Pharmaceuticals and Biotechnology, Tianjin University, Tianjin 300071, China. tpuwx@sohu.com Insititute of Nervous System Diseases Xuzhou Medical University Xuzhou China College of Veterinary Medicine, Sichuan Agricultural University, Wenjiang, Sichuan Province, China Key Laboratory of Flexible Electronics (KLOFE) and Institute of, Advanced Materials (IAM) Jiangsu National Synergistic Innovation Center for Advanced Materials (SICAM) Nanjing Tech University (NanjingTech) 30 South Puzhu Road Nanjing 211816 China Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, China From the Departments of Biochemistry (X.W., E.B., S.H.-A., C.F.-P.) and Physiology (A.T., Z.K.), Mazankowski Alberta Heart Institute (Z.K., C.F.-P.), Cardiovascular Research Group (Z.K., C.F.-P.), and Faculty of Medicine and Dentistry (X.W., E.B., S.H.-A., C.F.-P.), University of Alberta, Edmonton, Alberta, Canada. CAS Key Laboratory of Molecular Nanostructure and Nanotechnology, CAS Research/Education Center for Excellence in Molecular Sciences, Beijing National Laboratory for Molecular Science (BNLMS), Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China Center of Smart Interfaces, Technical University Darmstadt, 64287 Darmstadt, Germany; Mechanical Engineering Department, Dongguan University of Technology, 523808, Dongguan, China Neuroimmunology Branch, National Institute for Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 Department of Thoracic Surgery, The Second Xiangya Hospital of Central South University, Central South University, Changsha, Hunan, China; Hunan Key Laboratory of Early Diagnosis and Precise Treatment of Lung Cancer, The Second Xiangya Hospital of Central South University, Central South University, Changsha, Hunan, China Institute of Bismuth Science University of Shanghai for Science and Technology Shanghai 200093 China Department of Human Anatomy, Histology, and Embryology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education) and State Key Laboratory of Natural and Biomimetic Drugs, Peking University Health Science Center, Beijing 100191, China 1 Department of Chemistry Queen's University Kingston ON K7L 3N6 Canada Acupuncture and Tuina College, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610075, China Center for Environmental Implications of Nanotechnology, California NanoSystems Institute Department of Breast Surgical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China Department of Biomedicine University of Bergen Bergen Norway School of Health Science and Engineering, University of Shanghai for Science and Technology , Shanghai 200093 , China Key Laboratory for Intelligent Nano Materials and Devices of Ministry of Education, State Key Laboratory of Mechanics and Control of Mechanical Structures, and Institute for Frontier Science, Nanjing University of Aeronautics and Astronautics, Nanjing 210016, China School of Chemistry and Chemical Engineering, Huaiyin Normal University, Huaian 223300, People's Republic of China Department of Medical Oncology, Xuzhou Central Hospital, Xuzhou 221009, China. Department of Respiratory and Critical Care Medicine No.2 People's Hospital of Kunming Kunming Yunnan Province P.R. China Department of Endocrinology Affiliated Hospital of Medical College Qingdao University Qingdao China Medical Psychological Institute, The Second Xiangya Hospital, Central South University, No. 139 Middle Renmin Road, Changsha, Hunan 410011, China National Key Laboratory of Crop Genetic Improvement College of Plant Science and Technology Huazhong Agricultural University Wuhan China Catalonia Institute for Energy Research (IREC), Sant Adriá de Besós 08930, Barcelona, Spain Department of Radiology, Changzheng Hospital, Naval Medical University, Shanghai Department of Neurosurgery, West China Hospital, Sichuang University, Chengdu 610041, China. Nursing School Anhui University of Chinese Medicine Hefei Anhui China Department of Endocrinology The Affiliated Hospital of Qingdao University Qingdao China Department of Critical Care Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu 210006, P.R. China Department of Medical Oncology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China Department of Radiation Oncology, Kimmel Cancer Center of Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA. Department of Biochemistry, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland Department of Chemistry, Bohai University, Jinzhou, 121000, People’s Republic of China Department of Physical Education, Gansu University of Political Science and Law, Lanzhou 730030, China Key Laboratory of Biodiversity of Aquatic Organisms, Harbin Normal University, Harbin, Heilongjiang, P.R. China; Laboratory of Protozoa, College of Life Science and Technology, Harbin Normal University, Harbin, Heilongjiang, P.R. China Duke University, P. M. Gross Chemical Laboratory, Durham, North Carolina 27708-0346 Digestive Endoscopy Department & General Surgery Department, the First Affiliated Hospital with Nanjing Medical University & Jiangsu Province Hospital, Nanjing, China Department of General Surgery, Hefei Hospital Affiliated to Medical University of Anhui , Hefei 230011, Anhui , China Laboratory of Cardiovascular Immunology, Institute of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China Department of Thoracic and Cardiovascular Surgery, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, P.R. China Department of Neurology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, P. R. China; Department of Neurology, Shandong Provincial Hospital affiliated to Shandong First Medical University, Jinan, Shandong, P. R. China; Shandong Provincial Clinical Research Center for Geriatric Neurological Diseases, Jinan, Shandong, P. R. China Department of Neurology, Xiangya Hospital Central South University Changsha China; National Clinical Research Center for Geriatric Disorders Xiangya Hospital Central South University Changsha China Wuhan Institute of Biological Products Co., Ltd., Wuhan 430207, China Medical Psychological Institute of the Second Xiangya Hospital Changsha China Department of Anesthesiology, ZhuJiang Hospital of Southern Medical University, Guangzhou, Guangdong, China Key Laboratory for Intelligent Nano Materials and Devices of the Ministry of Education State Key Laboratory of Mechanics and Control of Mechanical Structures Nanjing University of Aeronautics and Astronautics Nanjing 210016 China Department of Endocrinology Affiliated Hospital of Medical College Qingdao University Qingdao China; Transfusion Section Chongqing University Three Gorges Hospital Qingdao China Department of Breast Surgery, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China Technical Center for Multifunctional Magneto‐Optical Spectroscopy (Shanghai) Department of Materials School of Physics and Electronic Science East China Normal University Shanghai 200241 P. R. China State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Sciences, Beijing, China.; Key Laboratory of Environmental and Applied Microbiology, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, China. Department of Curriculum and Instruction, the Education University of Hong Kong , Hong Kong , China Université de Bordeaux, CBMN, UMR5248 Institut Européen de Chimie et Biologie 2 rue Escarpit 33600 Pessac France; CNRS, CBMN, UMR5248 France Department of Chemistry and Biochemistry, University of Colorado, 215 UCB, Boulder, Colorado 80309 Department of Thoracic Surgery, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China; Hunan Key Laboratory of Early Diagnosis and Precise Treatment of Lung Cancer, Department of Thoracic Surgery, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China State Key Laboratory of Multiphase Complex Systems, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, P.R. China Department of Chemistry University of North Carolina at Chapel Hill Chapel Hill NC 27599 USA Chemical Sciences Division, Oak Ridge National Laboratory, Oak Ridge, TN 37831; Catalonia Institute for Energy Research - IREC, Sant Adrià de Besòs, 08930 Barcelona, Spain Department of Thoracic Surgery, The Second Xiangya Hospital, Central South University, Changsha, P.R. China Department of Breast Surgery, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China College of Resource and Environment Anhui Science and Technology University Fengyang China SHU-Solar E R&D Lab, Department of Physics, College of Sciences, Shanghai Key Laboratory of High Temperature Superconductors, Shanghai Frontiers Science Center of Quantum and Superconducting Matter States, Shanghai University, Shanghai200444, China Department of Materials Science and Engineering City University of Hong Kong 83 Tat Chee Avenue Kowloon Hong Kong SAR 999077 P. R. China Department of Radiology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430014, China Division of NanoMedicine, Department of Medicine University of California, Los Angeles, California 90095, United States; California NanoSystems Institute (CNSI), University of California, Los Angeles, California 90095, United States The State Key Laboratory of Subtropical Silviculture, Collaborative Innovation Center for Efficient and Green Production of Agriculture in Mountainous Areas of Zhejiang Province, Key Laboratory of Quality and Safety Control for Subtropical Fruit and Vegetable, Ministry of Agriculture and Rural Affairs, College of Horticulture Science, Zhejiang A&F University , Hangzhou 311300, Zhejiang , China Department of Thoracic Surgery Second Xiangya Hospital, Central South University Changsha China Institute of Molecular Medicine, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Jiao Tong University, Shanghai 200240, People’s Republic of China Department of Critical Care Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, Jiangsu Province, China School of Environmental and Chemical Engineering, Tianjin Polytechnic University, Tianjin, P. R. China Department of Chemistry and Center for Chemical Methodology and Library Development, Boston University, 590 Commonwealth Avenue, Boston, Massachusetts 02215 Department of Medical Oncology, Xuzhou Central Hospital, Xuzhou, China. Key Laboratory of Biodiversity of Aquatic Organisms, Harbin Normal University, Harbin 150025, China; State Key Laboratory of Urban Water Resource and Environment, School of Civil and Environmental Engineering, Harbin Institute of Technology (Shenzhen), Shenzhen 518055, China Department of Thoracic Surgery Second Xiangya Hospital of Central South University Hunan China Department of Breast Surgery Cancer Hospital Chinese Academy of Medical Sciences Beijing China University of Science and Technology of China, China Department of Emergency, Binzhou Medical University Hospital, Binzhou, Shandong, China College of Life Sciences, Zhejiang University, Hangzhou 310058, People's Republic of China; Key Laboratory for Translational Medicine, First Affiliated Hospital, Huzhou University, Huzhou 313000, People's Republic of China; State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, and Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310058, People's Republic of China School of Chemistry and Chemical Engineering, Xuzhou Normal University, Xuzhou, Jiangsu, 221116, P. R. China, and Jiangsu Key Laboratory of Molecular Medicine, Medical School Nanjing University Nanjing China Department of Breast Surgical Oncology, National Cancer Center/Cancer Hospital of Chinese Academy of Medical Sciences, Beijing 100021, China. Department of Radiology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China Chemical Process R&D, Amgen Inc., One Amgen Center Drive, Thousand Oaks, California 91320 Departments of Chemistry and Biochemistry, and Chemical & Biomolecular Engineering, University of Maryland, College Park, Maryland 20742-2111 Division of NanoMedicine, Department of Medicine, University of California, Los Angeles, California 90095, United States School of Pharmacy, Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, Jiangsu Province, People's Republic of China Beijing National Laboratory for Molecular Sciences CAS Research/ Education Center for Excellence in Molecular Sciences Institute of Chemistry Beijing 100190 P. R. China Orthopaedics Department The First Affiliated Hospital of Zhejiang Chinese Medical University Hangzhou China Department of Chemistry and Center for Streamlined Synthesis, Metcalf Center for Science and Engineering, Boston University, 590 Commonwealth Avenue, Boston, Massachusetts 02215, and Pharmacia Corporation, 800 North Lindbergh Blvd., St. Louis, Missouri 63167

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