http://rdf.ncbi.nlm.nih.gov/pubchem/author/MD5_5b1b2316afb457b9bd957b216027b5c5
Outgoing Links
Predicate | Object |
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family-name | Xin Huang Huang |
name | Xin Huang |
given-name | Xin |
organization-name | MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage School of Chemistry and Chemical Engineering Harbin Institute of Technology (HIT) Harbin 150001 P. R. China Key Laboratory of Nonferrous Metals Chemistry, and Resources Utilization of Gansu Province State Key Laboratory of Applied Organic Chemistry, and College of Chemistry and Chemical Engineering Lanzhou University Lanzhou 730000 China Natural Products Research Center; Chengdu Institution of Biology; Chinese Academy of Science; Chengdu 610041; P. R. China Department of Reproductive Medicine, Yantai Yuhuangding Hospital Affiliated to Qingdao University, Yantai, China Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Science, Lanzhou, China Department of Neurosurgery The First Affiliated Hospital, Zhejiang University School of Medicine Hangzhou China Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, Beijing, 100083, China Department of Orthopedics, Union Hospital Tongji Medical College, Huazhong University of Science and Technology Wuhan China West China Hospital, Sichuan University; Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University Eye Center, Renmin Hospital of Wuhan University, Wuhan, Hubei; Department of Ophthalmology, Jiangxi Provincial People’s Hospital, Nanchang Xinhua Hospital, Shanghai Second Medical University, Shanghai 200092, China. Department of Orthopaedic Surgery, Second Affiliated Hospital, Medical College of Zhejiang University, Hangzhou, Zhejiang 310009, China. Jiangsu Collaborative Innovation Centre of Biomedical Functional Materials, Jiangsu Key Laboratory of New Power Batteries, School of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, P. R. China Department of Chemistry, The Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana–Champaign, Urbana, IL 61801 Jiangsu Center for Pharmacodynamics Research and Evaluation, China Pharmaceutical University, Nanjing, China; Key Laboratory of Drug Quality Control and Pharmacovigilance, China Pharmaceutical University, Nanjing, China Xin Huang, Bin Meng, Wenfeng Cao, and Kai Fu, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Tianjin; Chengfeng Bi, West China Hospital, West China School of Medicine of Sichuan University, Chengdu, China; Xin Huang, Bin Meng, Javeed Iqbal, Anamarija M. Perry, Wenfeng Cao, Lynette M. Smith, Chengfeng Bi, Chunsun Jiang, Timothy C. Greiner, Dennis D. Weisenburger, James O. Armitage, Julie M. Vose, Timothy W. McKeithan, Wing C. Chan, and Kai Fu,... Natural Products Research Center, Chengdu Institute of Biology, Chinese Academy of Science, Sichuan, Chengdu 610041, PR China The First Affiliated Hospital of Anhui Medical University Hefei Anhui China Department of Hematology Guangdong General Hospital Guangdong Academy of Medical Sciences Guangzhou China Key Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100049, China Strategic Support Force Medical Center, Beijing, China Anhui Medical University, China State Key Laboratory and Institute of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, China Centre for Protolife Research and Centre for Organized Matter Chemistry, School of Chemistry, University of Bristol, Bristol BS8 1TS, United Kingdom School of Environmental and Chemical Engineering Shanghai University Shanghai China Department of General Surgery The Xi'an Central Hospital Xi'an Shaanxi People's Republic of China Department of Physics, Washington State University, 2710 University Drive, Richland, Washington 99354, Chemical & Materials Sciences Division, Pacific Northwest National Laboratory, MS K8-88, Post Office Box 999, Richland, Washington 99352, Department of Chemistry, Fuzhou University, Fuzhou, Fujian 350108, P. R. China, and State Key Laboratory of Structural Chemistry, Fuzhou, Fujian 350002, P. R. China State Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, China Natural Products Research Center Chengdu Institution of Biology Chinese Academy of Science Chengdu P. R. China Department of Orthopedics, Chengdu Seventh People's Hospital, Chengdu, Sichuan 610213, P.R. China Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai 200031, China;NHC Key Laboratory of Myopia (Fudan University); Key Laboratory of Myopia, Chinese Academy of Medical Sciences, Shanghai 200031, China;Shanghai Key Laboratory of Visual Impairment and Restoration, Shanghai 200031, China. Department of Orthopaedics of XiJing Hospital, Fourth Military Medical University, Xi'An, P.R. China. College of Life Sciences, Wuhan University, Wuhan 430072, China Eye Center Renmin Hospital of Wuhan University Wuhan Hubei China Fuzhou University 1 Department of Chemistry, , Fuzhou, Fujian 350108, People's Republic of China; Fujian Provincial Key Laboratory of Theoretical and Computational Chemistry 3 , Xiamen, Fujian 361005, People's Republic of China Eye Center, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei, China Department of Hematology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China; Key Laboratory of Hematologic Malignancies, Diagnosis and Treatment, Hangzhou, Zhejiang, China; Institute of Hematology, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China Authors' Affiliations: Departments of 1Otolaryngology, 2Cell Biology and Physiology, 3Pathology, 4Pharmacology and Chemical Biology, and 5Renal and Electrolyte Division, University of Pittsburgh Medical Center; 6Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh School of Medicine and Magee-Women's Research Institute, University of Pittsburgh Medical Center; 7Veterans Affairs Pittsburgh Health System; 8University of Pittsburgh Cancer Institute; 9Human Genetics, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania; 10Department of Cell Biology, Duke University Medical Center, Durham, North Carolina; 11Department of Molecular Genetics and Microbiology and the Genetics Institute, University of Florida, Gainesville, Florida; and 12Department of Physiology, University of Regensburg, Regensburg, Germany Department of Ophthalmology Eye & ENT Hospital of Fudan University Shanghai China Cancer Epigenetics Laboratory, Department of Clinical Oncology, State Key Laboratory of Oncology in South China, Sir YK Pao Center for Cancer and Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong and CUHK-Shenzhen Research Institute, Shatin, Hong Kong Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province Jiangnan University Wuxi P. R. China; State Key Laboratory of Food Science and Technology Jiangnan University Wuxi P. R. China; School of Food Science and Technology Jiangnan University Wuxi P. R. China Hefei National Laboratory for Physical Sciences at Microscale, University of Science and Technology of China, Hefei 230026, China;; Department of Modern Physics, University of Science and Technology of China, Hefei 230026, China;; Shanghai Branch, CAS Center for Excellence in Quantum Information and Quantum Physics, University of Science and Technology of China, Shanghai 201315, China;; Shanghai Research Center for Quantum Sciences, Shanghai 201315, China; Department of Chemistry, University of Massachusetts Boston, Boston, Massachusetts 02125, United States Eye Center, Renmin Hospital of Wuhan University, Wuhan, Hubei, PR China From Massachusetts General Hospital (L.J.W.) and Dana–Farber Cancer Institute (J. Lorch), Boston; Memorial Sloan Kettering Cancer Center, New York (E.S., A.D.); Royal North Shore Hospital, St. Leonards, NSW (B.R.), and Peter MacCallum Cancer Institute, Melbourne, VIC (B.S.) — both in Australia; University of California, San Francisco–Helen Diller Family Comprehensive Cancer Center, San Francisco (H.K.), David Geffen School of Medicine at UCLA, Los Angeles (J.W.G.), and Chao Family Comprehensive Cancer... Department of Neuroscience, University of Wisconsin-Madison, Madison, Wisconsin College of Pipeline and Civil Engineering, China University of Petroleum, No. 66 Changjiang West Road, Qingdao, Shandong 266580, China Guangxi Key Laboratory of Special Non-wood Forest Cultivation & Utilization, Guangxi Forestry Research Institute, Nanning, China Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Pain Medicine Center, Peking University Third Hospital, Beijing 100191, China Center of Clinical Epidemiology and Methodology Guangdong Second Provincial General Hospital Guangzhou China Department of Biology, Georgetown University, Washington, DC, USA Dental Department Shanghai Jing‐an Dental Clinic Shanghai China Fuzhou University 1 Department of Chemistry, , Fuzhou, Fujian 350108, China; Fujian Provincial Key Laboratory of Theoretical and Computational Chemistry 3 , Xiamen, Fujian 361005, China Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, PR China College of Data Science, Taiyuan University of Technology, Taiyuan 030024, China State Key Laboratory for Sheep Genetic Improvement and Healthy Production Xinjiang Academy of Agricultural and Reclamation Science Shihezi China School of Atmospheric Sciences, Nanjing University, Nanjing 210023, China Department of Orthopedic Oncology The Second Affiliated Hospital of Zhejiang University Hangzhou China; Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province Hangzhou China Department of Orthopaedics, Union Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan China Department of Neurosurgery, Lin Yi Central Hospital, Linyi, Shandong 276400, P.R. China Department of Urology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, P.R. China West China College of Stomatology, Sichuan University, Chengdu 610041, China. Eye and ENT Hospital, Shanghai Medical College, Fudan University, Shanghai, People’s Republic of China Department of Chemistry, Fuzhou University, Fuzhou, Fujian 350108, P. R. China, State Key Laboratory of Structural Chemistry, Fuzhou, Fujian 350002, P. R. China, Department of Physics, Washington State University, 2710 University Drive, Richland, Washington 99354, and Chemical & Materials Sciences Division, Pacific Northwest National Laboratory, MS K8-88, Post Office Box 999, Richland, Washington 99352 Department of Orthopedic Surgery The Second Affiliated Hospital Zhejiang University School of Medicine Orthopedics Research Institute of Zhejiang University Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province 88 Jiefang Road Hangzhou City Zhejiang Province 310003 P. R. China Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education & Key Lab of Swine Genetics and Breeding of Ministry of Agriculture and Rural Affairs, Huazhong Agricultural University, Wuhan 430070, P. R. China 1Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong, PR China and Department of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (mainland) School of Chemistry and Chemical Engineering; Nanjing University; Nanjing; China Eye Center, Renmin Hospital of Wuhan University, Wuhan University, Wuhan 430060, Hubei Province, China. Department of Reproductive Medicine, Yantai Yuhuangding Hospital, Affiliated Hospital of Medical College of Qingdao University, Yantai, Shandong, China, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences Nanjing University Nanjing China Department of Hematology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China; Zhejiang Provincial Key Lab of Hematopoietic Malignancy, Zhejiang University, Hangzhou, Zhejiang, China School of Mathematics and Information Science, Anshan Normal University , Anshan 114007, Liaoning , China Department of Molecular Structure and Characterization, ‡Department of Protein Technology, Amgen Inc., 360 Binney Street, Cambridge, Massachusetts 02142, United States AbbVie Inc, North Chicago, IL Department of Crop and Forest Sciences University of Lleida‐Agrotecnio CERCA Center Lleida Spain Pain Medicine Center and Department of Orthopaedics Peking University Third Hospital Beijing China Industry and University Research Cooperation Demonstration Base of Science and Technology Agency in Fujian Province, College of Life Science, Ningde Normal University, Ningde 352100, China; Key Laboratory of Bio-Pesticide and Chemistry Biology, Fujian Agricultural and Forestry University, Ministry of Education, Fuzhou 350002, China; College of Life Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China Department of Physics, Southeast University, Nanjing 211189, China The Key Laboratory of Dairy Science of Education Ministry Northeast Agricultural University Harbin China School of Chemical Engineering and Technology; Harbin Institute of Technology; Harbin; China Key Laboratory of the Ministry of Education for Advanced Catalysis Materials, Zhejiang Normal University, Jinhua 321004, China CAS Key Laboratory of Colloid and Interface Science, Institute of Chemistry, The Chinese Academy of Sciences (CAS), 100080, Beijing, People's Republic of China Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing, China; Jiangsu Center for Pharmacodynamics Research and Evaluation, China Pharmaceutical University, Nanjing, China Department of Medicinal Chemistry, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China Department of Medicine, Columbia Center for Human Development, Columbia Stem Cell Initiative, Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY, USA Department of Chemistry; Capital Normal University; Beijing; China Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139; and Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02115 Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing 100191, China Department of Chemistry, Tsinghua University, Beijing 100084, People's Republic of China, and Department of Chemical Engineering, Jilin Institute of Chemical Technology, Jilin, 132022, People's Republic of China *State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China;; †University of Chinese Academy of Sciences, Beijing 100049, China; Department of Breast Disease, Peking Union Medical College Hospital, Peking Union Medical College, Beijing 100730, China Authors' Affiliations: 1Medical Oncology Branch, National Cancer Institute, NIH, Bethesda, Maryland; 2Silberman Institute of Life Sciences, Hebrew University, Jerusalem, Israel; 3Pfizer, Inc., La Jolla, California; and 4Memorial Sloan-Kettering Cancer Center, New York, New York Department of Neuroscience, School of Medical and Public Health, McPherson Eye Research Institute, University of Wisconsin-Madison, Madison, Wisconsin Laboratory of Molecular Recognition and Synthesis, Department of Chemistry, Zhejiang University, Hangzhou, 310027 Zhejiang, People’s Republic of China Jonas Bergh and Annelie Liljegren, Karolinska Institutet and University Hospital, Stockholm, Sweden; Jonas Bergh, University of Manchester, Paterson Institute for Cancer Research, Manchester, United Kingdom; Igor M. Bondarenko, Dnipropetrovsk City Multiple-Discipline Clinical Hospital No. 4, Dnipropetrovsk; Nataliya L. Voytko, Kyiv City Oncologic Hospital, Kyiv, Ukraine; Mikhail R. Lichinitser, National Cancer Research Center; Anatoly N. Makhson, City Oncology Clinical Hospital No. 62, Moscow, Russian... Department of Obstetrics, The First Affiliated Hospital of Jinzhou Medical University , Jinzhou , Liaoning 121000 , P.R. China Department of Applied Physics, Aalto University, 00076 Aalto, Finland From the Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton; The Cancer Institute of New Jersey, New Brunswick, NJ; Division of Gastrointestinal Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL; Divisions of Medical Science and Population Science, Fox Chase Cancer Center, Philadelphia, PA; Institute for Drug Development, Cancer Therapy and Research Center, San Antonio, TX; Division of Medical Oncology, Washington University School of Medicine, St Louis, MO; Case... Department of Orthopaedics, School of Medicine, Second Affiliated Hospital Zhejiang University Hangzhou China Department of Cardiology, West China Hospital, Sichuan University/West China School of Nursing, Sichuan University Chengdu 610000, Sichuan Province, China. Authors' Affiliations: 1Pfizer Oncology, San Diego, California; 2Mount Sinai Hospital and the University of Toronto, Toronto, Ontario, Canada; 3H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida; 4University Hospital Gasthuisberg, Leuven, Belgium; 5Ohio State University Comprehensive Cancer Center, Columbus, Ohio; 6Erasmus University Medical Center, Rotterdam, the Netherlands; and 7Ludwig Center at Dana-Farber/Harvard Cancer Center, Boston, Massachusetts School of Life Science and Biopharmacology, Guangdong Pharmaceutical University, Guangzhou, Guangdong 510006, China. Center for Ecosystem Science and Society Department of Biological Sciences Northern Arizona University Flagstaff AZ USA College of Life Science and Bioengineering; Beijing Key Laboratory of Environmental and Oncology; Beijing University of Technology; Beijing; China Department of Biomedical Sciences, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong, China Department of Pharmacy, Shandong Provincial Qianfoshan Hospital Shandong University Jinan China Yunnan Center for Disease Control and Prevention, Kunming 650022, China. School of Life Sciences, Anhui University Hefei, AnhuiChina School of Computer Science & Technology, Dalian University of Technology, Dalian 116023, China College of Chemistry; Fuzhou University; Fuzhou; Fujian 350116; P. R. China Cornell High Energy Synchrotron Source, Cornell University, Ithaca, New York 14853, United States Department of Plastic and Reconstructive Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China Department of Chemistry and Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Institute of New Energy, iChEM (Collaborative Innovation Centre of Chemistry for Energy Materials), Fudan University, Shanghai 200433, China Sichuan Academy of Medical Sciences, Sichuan Provincial People's Hodpital, Chengdu, 610072. Department of Radiology, the First Affiliated Hospital of Xi’an Jiaotong University, Shaanxi province, China Department of Cardiology, Beijing Anzhen Hospital Capital Medical University Beijing China Contribution from the Department of Applied Biology & Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, and Department of Chemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong National Drug Screening Center, China Pharmaceutical University Department of Orthopaedics, Tongji Medical College, Union Hospital Huazhong University of Science and Technology Wuhan China Beijing Institute of Radiation Medicine, Beijing , China Guangdong Provincial Key Laboratory of Advanced Drug Delivery Systems, Guangdong Pharmaceutical University, Guangzhou, PR China; Guangdong Provincial Engineering Center of Topical Precise Drug Delivery Systems, Guangdong Pharmaceutical University, Guangzhou, PR China; R&D Team for Formulation Innovation, Guangdong Pharmaceutical University, Guangzhou, PR China Beijing Institute of Radiation Medicine, Beijing 100850, China Departments of Pathology and Microbiology University of Nebraska Medical Center Omaha NE USA University of California, Los Angeles Wuhan Hospital of Traditional Chinese Medicine, Wuhan, China. Key Laboratory of the Ministry of Education for Advanced Catalysis Materials Zhejiang Normal University Jinhua 321004 China Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing Genetron Health (Beijing) , Beijing , China Eye and Ear, Nose and Throat Hospital Shanghai Medical College, Fudan University Shanghai China; Shanghai Key Laboratory of Visual Impairment and Restoration Fudan University Shanghai China Hepatopancreatobiliary Center, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Institute for Precision Medicine, Tsinghua University, Beijing, China. Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, Beijing 100083, China; CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology (NCNST), Beijing 100190, China; University of Chinese Academy of Sciences, Beijing 100049, China 1Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine and Magee Women's Research Institute, Pittsburgh, Pennsylvania. Department of Chemistry Research and Discovery, ‡Department of Pharmacokinetics and Drug Metabolism, §Oncology Research, ∥Department of Molecular Structure, ⊥Bioassay and Profiling, and #Pharmaceutics, Amgen Inc., 360 Binney Street, Cambridge, Massachusetts 02142, United States Department of Hematology, the First Affiliated Hospital Zhejiang University, College of Medicine Hangzhou Zhejiang People's Republic of China; Zhejiang Provincial Key Lab of Hematopoietic Malignancy Zhejiang University Hangzhou Zhejiang People's Republic of China Department of Civil and Environmental Engineering, Imperial College London, London SW7 2AZ, UK; Department of Civil and Environmental Engineering, The University of Hong Kong, Pokfulam Road, Hong Kong, People's Republic of China Department of Clinical Pharmacy, The First Affiliated Hospital of Shandong First Medical University, Jinan, China; Clinical Research Center, The First Affiliated Hospital of Shandong First Medical University, Jinan, China School of Applied and Engineering Physics, Cornell University, Ithaca, New York 14853, United States; Cornell High Energy Synchrotron Source, Cornell University, Ithaca, New York 14853, United States Microbial Genomics Section, Translational and Functional Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA State Key Laboratory of Drug Research and Center of Pharmaceutics Shanghai Institute of Materia Medica Chinese Academy of Sciences 501 Haike Road Shanghai 201203 China; School of Pharmacy University of Chinese Academy of Sciences Beijing 100049 China Department of Reproductive Medicine, Yuhuangding Hospital Affiliated to Qingdao University, Yantai, Shandong, China (mainland) Department of Thoracic Surgery, First Affiliated Hospital of Anhui Medical University, Hefei 230032, P. R. China Department of Ophthalmology, Jiangxi Provincial People’s Hospital, The First Affiliated Hospital of Nanchang Medical College State Key Laboratory of Marine Environmental Science, Xiamen University, Xiamen, China Department of Clinical Pharmacy, the First Affiliated Hospital of Shandong First Medical University;; Clinical Research Center, the First Affiliated Hospital of Shandong First Medical University ; and Department of Neuroscience, University of Wisconsin, Madison, Wisconsin; The Key Laboratory of Dairy Science of Education Ministry, Northeast Agricultural University, Harbin, China. Department of Chemistry; Zhejiang Normal University; Jinhua 321004; China Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Key Laboratory of Precision Nutrition and Food Quality Ministry of Education Department of Nutrition and Health China Agricultural University Beijing 100083 China; Beijing Advanced Innovation Center for Food Nutrition and Human Health Department of Nutrition and Health China Agricultural University Beijing 100083 China Department of Ophthalmology, Jiangxi Provincial People’s Hospital, Nanchang, Jiangxi, China Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China Department of Chemistry, Capital Normal University, Beijing 100048, China Institute of Bioinformatics, Zhejiang University, Hangzhou, Zhejiang Province, China; Center for General Practice Medicine, Department of General Practice Medicine; Center for Reproductive Medicine, Department of Genetic and Genomic Medicine, and Clinical Research Institute, Zhejiang Provincial People’s Hospital, People’s Hospital of Hangzhou Medical College, Hangzhou, Zhejiang, China Department of Cardiology, The First Hospital of Nanchang, The Third Affiliated Hospital of Nanchang University. Xiangshan North Road 128, Nanchang, Jiangxi 330008, China.; Department of Cardiology, The First Hospital of Nanchang, The Third Affiliated Hospital of Nanchang University. Xiangshan North Road 128, Nanchang, Jiangxi 330008, China. 7Vincerx Pharma Inc, Palo Alto, California. Natural Products Research Center; Chengdu Institute of Biology; University of Chinese Academy of Sciences; Chengdu; P. R. China Department of Breast Disease, Peking Union Medical College Hospital, Beijing, China (mainland) School of Materials Science and Engineering, Nanyang Technological University 50 Nanyang Avenue 639798 Singapore Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University Cornell High Energy Synchrotron Source, Cornell University, Ithaca, NY 14850; Department of Nuclear Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, P.R. China AbbVie, Inc. North Chicago IL U.S.A. Natural Products Research Center, Chengdu Institution of Biology, Chinese Academy of Science, Chengdu 610041, P. R. China The Howard Hughes Medical Institute and the Ludwig Center for Cancer Genetics and Therapeutics at The Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, 1650 Orleans Street, CRB1, Baltimore, Maryland 21231 Department of Obstetrics and Gynecology, The First Affiliated Hospital of Jinzhou Medical University , Jinzhou , Liaoning 121000 , China Division of Reproductive Medicine, West China Second University Hospital of Sichuan University , Chengdu, Sichuan , China; Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education , Chengdu, Sichuan , China; NHC Key Laboratory of Chronobiology (Sichuan University) , Chengdu, Sichuan , China Department of Oral and Maxillofacial‐Head and Neck Oncology, Beijing Stomatological Hospital Capital Medical University Beijing China Department of Human Genetics, University of Pittsburgh Graduate School of Public Health, Oral Cancer Center at the University of Pittsburgh, University of Pittsburgh Cancer Institute, and Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261 Department of Breast Surgery, The First Affiliated Hospital of Jinan University, Guangzhou, China Division of Surgical Research, Department of Surgery, Rhode Island Hospital/Alpert School of Medicine at Brown University, Providence, RI 02903 Center of Clinical Pharmacology, The Third Xiangya Hospital Central South University Changsha China Key Laboratory of Cluster Science Ministry of Education Beijing Key Laboratory of Photoelectronic/Electrophotonic Conversion Materials Advanced Technology Research Institute (Jinan) School of Chemistry and Chemical Engineering Beijing Institute of Technology Beijing 100081 P. R. China Department of epidemiology, Medical School of Hunan Normal University, Changsha, China Laboratory of Plant Nematology and Research Center of Nematodes of Plant Quarantine, Department of Plant Pathology, Guangdong Province Key Laboratory of Microbial Signals and Disease Control, College of Agriculture, South China Agricultural University, Guangzhou, Guangdong Province, People’s Republic of China Department of Gastrointestinal Surgery, Changzheng Hospital, Naval Medical University, Shanghai, China Department of Pharmacy, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, China School of Bioengineering, Dalian University of Technology, Dalian 116024, Liaoning, China. Department of Stomatology, Nanfang Hospital, College of Stomatology, Southern Medical University, Guangzhou, PR China. Kunming Medical University, Kunming, 650500, P. R. China. Applied Genomics, Bristol-Myers Squibb Research and Development, New Jersey, USA Center of Clinical Pharmacology, The Third Xiangya Hospital, Central South University Department of General Practice Medicine, Shengjing Hospital Affiliated to China Medical University, Shenyang 110000, China. College of Petroleum and Chemical Engineering, Jingzhou University, Jingzhou 434000, Hubei, China Amgen Inc., South San Francisco, Calif., U.S.A. Division of Drug Discovery, Hongyun Biotech Co., Ltd. Nanjing China Key Laboratory of Longevity and Aging‐Related Diseases Ministry of Education Beijing China; Center for Translational Medicine Guangxi Medical University Nanning Guangxi China Shenzhen Key Laboratory for Systemic Aging and Intervention, National Engineering Research Center for Biotechnology (Shenzhen), Medical Research Center, Shenzhen University Health Science Center, Shenzhen 518055, China Division of Drug Discovery Hongyun Biotech Co., Ltd. Nanjing China Flexible Electronics Research Center, School of Mechanical Science and Engineering, Huazhong University of Science and Technology, Wuhan, Hubei 430074, People’s Republic of China Key Laboratory of Luminescence and Optical Information, Ministry of Education, Beijing JiaoTong University, Beijing 100044, China State Key Joint Laboratory of Environmental Simulation and Pollution Control, Department of Environmental Science, Peking University, Beijing 100871, China Department of Epidemiology and Biostatistics School of Medicine Hunan Normal University Changsha China Key Laboratory of Luminescence and Optical Information; Ministry of Education; Beijing Jiao Tong University; Beijing; China University of Science and Technology of China Organ Transplantation Institute, Medical College, Xiamen University, Xiamen City, Fujian Province, PR China Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia. Graduate School, Chinese Academy of Sciences, Beijing 100049, PR China; State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, PR China Department of Neurology, Beijing Luhe Hospital, Capital Medical University, Beijing, China Flexible Electronics Research Center, School of Mechanical Science and Engineering, Huazhong University of Science and Technology, Wuhan, Hubei 430074, P. R. China College of Land Engineering, Chang'an University, Xi'an 710054, China. School of Chemistry and Chemical Engineering Nanjing University Nanjing Jiangsu 210023 P. R. China Department of Breast Surgery; Peking Union Medical College Hospital; Beijing China Joint International Research Laboratory of Atmospheric and Earth System Sciences, School of Atmospheric Sciences, Nanjing University, Nanjing 210023, China; Jiangsu Provincial Collaborative Innovation Center for Climate Change, Nanjing 210023, China The Florey Institute of Neuroscience the University of Melbourne Parkville Victoria Australia State Key Laboratory of Military Stomatology and National Clinical Research Center for Oral Diseases and Shaanxi Clinical Research Center for Oral Diseases, Department of Oral and Maxillofacial Surgery, School of Stomatology, The Fourth Military Medical University, Xi'an, Shaanxi 710032, P.R. China Reproduction Medical Center, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, Shandong 264000, P.R. China Beijing Institute of Nanoenergy and Nanosystems Chinese Academy of Sciences Beijing 100083 China New Drug Screening Center, Jiangsu Center for Pharmacodynamics Research and Evaluation, China Pharmaceutical University, Nanjing 210009, China Department of General Surgery, Qilu Hospital of Shandong University, Jinan, People’s Republic of China Collaborative Innovation Centre of Chemical Science and Engineering Tianjin 300072 P. R. China; National Engineering Research Centre of Industrial Crystallization Technology School of Chemical Engineering and Technology Tianjin University Tianjin 300072 P. R. China MIIT Key Lab of Critical Materials Technology for New Energy Conversion and Storage School of Chemistry and Chemical Engineering Harbin Institute of Technology Harbin 150090 China From the Department of Brain Protection and Plasticity (X.H., J.S., T.Z., K.-W.W., L.-L.Z., M.F.), Institute of Basic Medical Sciences, Beijing, China; the Department of Bioengineering (K.W.), Nagaoka University of Technology, Nagaoka, Niigata, Japan; Nagaoka National College of Technology (K.W.), Nagaoka, Niigata, Japan; the Institute of Molecular and Clinical Medicine (Z.-C.X.), Kunming Medical College, Kunming, China; and Monash Immunology and Stem Cell Laboratories (Z.-C.X.), Monash University,... Department of Chemistry, Fuzhou University, Fuzhou, Fujian 350108, P. R. China Department of Pathology, Caoxian People’s Hospital of Shandong, Heze, Shandong, China Department of Hematology, Biodynamic Optical Imaging Center (BIOPIC) and Lymphoma Research Center, Third Hospital, Peking University, Beijing 100084, China Department of Infectious Diseases The Third Xiangya Hospital of Central South University Changsha Hunan China Department of Orthopaedics, The Second Affiliated Hospital of Zhejiang University School of Medicine, Centre for Orthopaedic Research, Orthopedics Research Institute of Zhejiang University, Hangzhou, China State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Guangzhou China; Department of Hepatobilliary Oncology Sun Yat‐sen University Cancer Center Guangzhou China Department of Chemistry, Fuzhou University, Fuzhou, Fujian 350108, P. R. China; State Key Laboratory of Structural Chemistry, Fuzhou, Fujian 350002, P. R. China Hubei Key Laboratory of Biomass Fibers and Eco-dyeing & Finishing College of Chemistry and Chemical Engineering Wuhan Textile University Wuhan 430200 China Department of Pharmacy West China Hospital of Sichuan University and Collaborative Innovation Center of Biotherapy Chengdu Sichuan China; Laboratory of Clinical Pharmacy and Adverse Drug Reaction West China Hospital of Sichuan University and Collaborative Innovation Center of Biotherapy Chengdu Sichuan China Pfizer, New York, NY, USA Department of Chemistry, University of Massachusetts, 100 Morrissey Boulevard, Boston, Massachusetts 02125, United States Department of Plant Pathology, College of Agriculture, Guizhou University, Guiyang, China Centre for Protolife Research and Centre for Organized Matter Chemistry; School of Chemistry; University of Bristol; Bristol BS8 1TS, UK Department of Chemical Engineering, School of Chemistry and Chemical Engineering Nanjing University Institute of Chemical Materials China Academy of Engineering Physics (CAEP) Mianyang 621900 China Energy Materials Computing Center, School of Energy and Mechanical Engineering, Jiangxi University of Science and Technology, Nanchang 330013, China AbbVie, Inc. North Chicago Ilinois Food Science and Technology Program, Department of Life Sciences, BNU-HKBU United International College, Zhuhai, Guangdong 519087, China Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China Natural Products Research Center, Chengdu Institution of Biology, Chinese Academy of Science, Chengdu 610041, P.R. China Department of Clinical Pharmacy, School of Pharmaceutical Sciences, Shandong University, Jinan, China; Department of Pharmacy, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, China Department of Cardiology, the First Affiliated Hospital of Xi’an Jiaotong University Health Science Center, Xi’an, Shaanxi 710061, China Department of Neurology, First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China. Key Laboratory of Environmental Remediation and Ecosystem Health, Ministry of Education College of Environmental and Resource Sciences, Zhejiang University Hangzhou China Department of Pathology and Microbiology, Mass Spectrometry and Proteomics Core Facility, University of Nebraska Medical Center, Omaha, Nebraska 68198, Department of Oncology, Zhongnan Hospital, Wuhan, Hubei Province, China 430071, and Biological Sciences Division, Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, Washington 99135 State Key of Pharmaceutical Biotechnology, School of Life Science Nanjing University 163 Xianlin Avenue Nanjing 210023 China Department of Cell Biology, Cancer Dormancy and Tumor Microenvironment Institute, Gruss-Lipper Biophotonics Center, Albert Einstein Cancer Center, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY, USA. 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China *Shock-Trauma Research Laboratories, Division of Surgical Research, Department of Surgery, and Department of Hematology, The First Affiliated Hospital, Zhejiang University College of Medicine, Hangzhou, Zhejiang, China;; Institute of Hematology, Zhejiang University, Hangzhou, Zhejiang, China;; Key Laboratory of Hematologic Malignancies, Diagnosis and Treatment, Hangzhou, Zhejiang, China Zhejiang; University of Science and Technology of China, Hefei, China Department of Neurosurgery, First Affiliated Hospital, Zhejiang University School of Medicine, China Collaborative Innovation Center of Sichuan for Elderly Care and Health, Chengdu Medical College, Sichuan, China; Department of Orthopedics, Chengdu Seventh People’s Hospital (Orthopedics, Affiliated Cancer Hospital, Chengdu Medical College), Sichuan, China; Department of Orthopedics, First Affiliated Hospital of Chengdu Medical College, Sichuan, China Department of Neurology The First Affiliated Hospital of Sun Yat‐sen UniversitySun Yat‐sen University Guangzhou China; Guangdong Provincial Key Laboratory for Diagnosis and Treatment of Major Neurological Disease Guangzhou China From the State Key Laboratory of Military Stomatology and National Clinical Research Center for Oral Diseases and Shaanxi Clinical Research Center for Oral Diseases; and the Department of Oral and Maxillofacial Surgery, School of Stomatology, Fourth Military Medical University. i-Lab and Division of Nanobiomedicine, CAS Key Laboratory of Nano-Bio Interface, CAS Center for Excellence in Nanoscience, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou 215123, China Oncology Center, Affiliated Hospital of Guangdong Medical University , Zhanjiang , 524001 , China Department of Chemistry, Zhejiang University, Hangzhou 310028, P. R. China Shanghai Key Laboratory of Materials Protection and Advanced Materials in Electric Power, Shanghai Engineering Research Center of Energy-Saving in Heat Exchange Systems, Shanghai University of Electric Power, Shanghai 200090, China Center for Molecular Biology of Oral Diseases, University of Illinois-Chicago, Chicago, Illinois 60612, United States From the Departments of Pathology and Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK; the Department of Biochemistry and College of Medicine, University of Illinois at Urbana-Champaign, Urbana, IL; and the School of Chemical, Biological and Materials Engineering, University of Oklahoma, Norman, OK. Department of Hematology, Guangdong Provincial People′s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, Guangdong, People’s Republic of China School of Public Health; Nantong University; Nantong 226019; P. R. 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Box 919-311, Mianyang, Sichuan, 621999, China; School of Physics and Optoelectronics, Xiangtan University, Xiangtan, Hunan, 411105, China Magee-Womens Research Institute, Department of Obstetrics, Gynecology and Reproductive Science, University of Pittsburgh, Pittsburgh, Pennsylvania, USA Jilin Ginseng Academy, Changchun University of Chinese Medicine, Changchun, Jilin Province, P. R. China Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology, and the NMPA Laboratory of Respiratory Disease, School of Pharmaceutical Sciences and the Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou 511436, China Fuzhou University 2 College of Chemistry, , Fuzhou, Fujian 350108, China Researcher, Department of Psychiatry, University Health Network, Toronto, Ontario; Research Assistant, University of Toronto, Toronto, Ontario Department of Hepatopancreatobiliary Surgery, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, PR China; Department of Assisted Reproduction, and Clinical and Translational Research Center, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, China Department of Surgery, Division of Surgical Research, Alpert School of Medicine at Brown University/Rhode Island Hospital , Providence, Rhode Island, China Department of Physics, Washington State University, 2710 University Drive, Richland, Washington 99354, Chemical & Materials Sciences Division, Pacific Northwest National Laboratory, MS K8-88, P.O. 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China Department of Molecular Structure, Amgen Inc., 360 Binney Street, Cambridge, Massachusetts 02142, United States Department of Orthopedic Surgery The Second Affiliated Hospital Zhejiang University School of Medicine Orthopedics Research Institute of Zhejiang University Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province Clinical Research Center of Motor System Disease of Zhejiang Province Hangzhou Zhejiang Province 310000 P. R. China School of Pharmacy, Anhui Province Key Laboratory of Major Autoimmune Diseases, Anhui Institute of Innovative Drugs, Anhui Medical University, Hefei, People's Republic of China Laboratory of Molecular Recognition and Synthesis, Department of Chemistry, Zhejiang University Prescriptions Department, College of Traditional Chinese Medicine, Chongqing Medical University, Yuzhong, Chongqing, China (mainland) Department of Orthopaedics Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan China State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Wuhan, China; Department of Periodontology, School & Hospital of Stomatology, Wuhan University, Wuhan, China School of Chemistry and Chemical Engineering; Shandong University of Technology; Zibo 255049; P. R. China Key Laboratory for Supramolecular Structure and Materials of Ministry of Education, Jilin University, Changchun 130012, Peoples Republic of China Department of Urology Renmin Hospital of Wuhan University Wuhan China Department of Physics, Washington State University, 2710 University Drive, Richland, Washington 99352, and W. R. Wiley Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, MS K8-88, Post Office Box 999, Richland, Washington 99352 College of Biological, Chemical Sciences and Engineering, Jiaxing University, Jiaxing 314001, China; College of Agronomy and Biotechnology, Hebei Normal University of Science and Technology, Qinhuangdao 066000, China Department of Pathology and Microbiology and Department of Chemistry and Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials Institute of New Energy iChEM (Collaborative Innovation Center of Chemistry for Energy Materials) Fudan University Shanghai 200433 China Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska 68198, United States 1Division of Immunology and Hematopoiesis, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland and AbbVie Inc. North Chicago Illinois USA Center for Hepatopancreatobiliary Diseases, Beijing Tsinghua Changgung Hospital, Tsinghua University Medical Center, Beijing, China. Department of Hepatopancreatobiliary Surgery, Beijing Tsinghua Changgung Hospital, Medical Center Tsinghua University Beijing China Department of Endocrinology and Metabolism The Second Affiliated Hospital of ZheJiang University School of Medicine Hangzhou China New drug screening center, Jiangsu Center for Pharmacodynamics Research and Evaluation, China Pharmaceutical University, Nanjing, 210009, China; Key Laboratory of Drug Quality Control and Pharmacovigilance, Ministry of Education, China Pharmaceutical University, Nanjing, 210009, China Department of Plastic and Reconstructive Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China Medical School of Hunan Normal University Changsha China Guangxi Forestry Research Institute, Guangxi Key Laboratory of Special Non-wood Forest Cultivation & Utilization, Nanning, China Department of Immunology, Nankai University School of Medicine and Key Laboratory of Bioactive Materials, Nankai University, Ministry of Education, People’s Republic of China Department of Hepatobiliary Surgery, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, P.R. China Division of Surgical Research, Rhode Island Hospital, Providence, RI 02903 Department of Cardiology, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, P.R. China, 710061. Department of Surgery, Chengdu Second People’s Hospital, Chengdu, Sichuan 610017, China State Key Laboratory of Polymer Materials Engineering Polymer Research Institute of Sichuan University Chengdu 610065 China Department of Dermatology The First Hospital of Hebei Medical University Shijiazhuang China; Candidate Branch of National Clinical Research Center for Skin Diseases Shijiazhuang China Guangxi Forestry Research Institute, Nanning, China Department of Pharmaceutical Engineering, School of Engineering, China Pharmaceutical University, Nanjing 210009, PR China Department of Biotechnology, Beijing Institute of Radiation Medicine, Beijing, China The First Affiliated Hospital, Zhejiang University School of Medicine, Department of Neurosurgery and Pediatrics, Hangzhou, China Department of Ophthalmology, Eye and ENT Hospital, Shanghai Medical College, Fudan University, Shanghai, China 2Shanghai Key Laboratory of Visual Impairment and Restoration, Fudan University, Shanghai, China Department of Laboratory Medicine, the First People's Hospital of Leshan; Department of Biochemistry and Molecular Biology, West China School of Preclinical and Forensic Medicine, Sichuan University School of Chemical Engineering and Technology, Harbin Institute of Technology, 150001 Harbin, Heilongjiang, China Department of Pediatrics, University of Southern California Department of Medicinal Chemistry, College of Pharmacy, Chongqing Medical University, Chongqing 400016, PR China Division of Surgical Research, Rhode Island Hospital/Brown University , Providence, Rhode Island , USA Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, P.R. China. Department of Biostatistics, UCLA School of Public Health, University of California, Los Angeles (UCLA), Los Angeles, California; the 18Loxo Oncology, a subsidiary of Eli Lilly and Company, Indianapolis, Indiana. Department of Ophthalmology, Eye and ENT Hospital of Fudan University, Shanghai, China;; Shanghai Key Laboratory of Visual Impairment and Restoration, Fudan University, Shanghai, China;; Key NHC Laboratory of Myopia (Fudan University), Key Laboratory of Myopia, Chinese Academy of Medical Sciences, Shanghai, China; and Department of Cognitive Sciences Beijing Institute of Basic Medical Sciences Beijing China Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection School of Public Health, Tongji Medical College, Huazhong University of Science and Technology Wuhan China; Department of Epidemiology and Biostatistics School of Public Health, Tongji Medical College, Huazhong University of Science and Technology Wuhan China Beijing Institute of Nanoenergy and Nanosystems Chinese Academy of Sciences National Center for Nanoscience and Technology (NCNST) Beijing 100083 China Key Laboratory of Drug-Targeting and Drug Delivery System of the Ministry of Education, Department of Medicinal Chemistry, West China School of Pharmacy and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China, and College of Pharmacy, Third Military Medical University, Shapingba, Chongqing 400038, China Department of Cardiology, Capital Medical University Affiliated Anzhen Hospital, Beijing 100089, China Hunan Key Laboratory of Biomedical Nanometer and Device, Hunan University of Technology, Zhuzhou 412007, P. R. China Chengdu Fifth People's Hospital, Chengdu, China 3Pfizer, New York, New York. Eye Center, Renmin Hospital of Wuhan University, Wuhan, 430060 Hubei, China State Key Laboratory of Supramolecular Structure and Materials, Jilin University, Changchun 130023, People's Republic of China, and Key Laboratory for Molecular Enzymology and Engineering of the Ministry of Education, Jilin University, Changchun 130023, People's Republic of China Reproductive Medicine Center, Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, Shandong 264000, P.R. China Department of Stomatology, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou 510623, China From Memorial Sloan Kettering Cancer Center and Weill Cornell Medical College (A.D., E.R.) and New York University Langone Medical Center (V.V.), New York, and Roswell Park Comprehensive Cancer Center, Buffalo (G.K.D.) — all in New York; Dana–Farber Cancer Institute (G.R.O.) and Massachusetts General Hospital (J.G.), Boston; National Cancer Centre Singapore, Singapore (D.S.W.T.); the Chinese University of Hong Kong, Hong Kong, China (H.H.F.L.); Sarah Cannon Research Institute, Nashville (M.J.);... Department of Biotechnology, Beijing Institute of Radiation Medicine, Beijing, P.R.China Department of Pharmaceutical Engineering School of Engineering China Pharmaceutical University Nanjing 210009 China Department of Plastic and Reconstructive Surgery, Shanghai Ninth People’s Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China International Research Centre for Environmental Membrane Biology, Foshan University, Foshan 528041, China Department of Orthopaedic Surgery, The Second Affiliated Hospital, Medical College of Zhejiang University, Hangzhou 310009, China; Institute of Orthopaedic Research, Zhejiang University, Hangzhou 310027, China Department of Clinical Pharmacy, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Engineering and Technology Research Center for Pediatric Drug Development, Shandong Medicine and Health Key Laboratory of Clinical Pharmacy, Jinan, Shandong250014, China School of Biomedical Engineering, The Sixth Affiliated Hospital Guangzhou Medical University Guangzhou Guangdong China Institute of HematologyMedical College, Jinan University, Guangzhou, China; Department of HematologyGuangdong General Hospital (Guangdong Academy of Medical Sciences), Guangzhou, China Cancer Institute, College of Medicine, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.; Zhejiang-California International NanoSystems Institute, Zhejiang University, Hangzhou, China. Department of Biology, Georgetown University, Washington, DC 20057; Department of Hematology Guangdong Provincial People’s Hospital Guangdong Academy of Medical Sciences School of Medicine South China University of Technology Guangzhou Guangdong 510080 P.R. China 1Surgery, Departments of MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage School of Chemistry and Chemical Engineering Harbin Institute of Technology Harbin 150001 P. R. China Department of Physics, Washington State University, 2710 University Drive, Richland, Washington 99354, W. R. Wiley Environmental Molecular Sciences Laboratory and Chemical Sciences Division, Pacific Northwest National Laboratory, P.O. Box 999, MS K8-88, Richland, Washington 99352, and School of Chemistry, The University of Melbourne, Victoria, Australia, 3010 Clinical Trials Center Cardiovascular Research Foundation New York New York; Department of Cardiology, First Affiliated Hospital of Xi'an Jiaotong University Xi'an Shaanxi China State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, China (mainland) Applied Genomics, Bristol-Myers Squibb Research and Development, Hopewell, New Jersey, USA Department of Urology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China Department of Ophthalmology, Jiangxi Provincial People’s Hospital Affiliated to Nanchang University, Nanchang, Jiangxi Beijing National Laboratory for Molecular Sciences Chinese Academy of Sciences Beijing 100190 P. R. China MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage, State Key Laboratory of Urban Water Resource and Environment, School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin, 150001, China Obstetrics Departments of Therapeutic Discovery, ‡Pharmaceutics, and §Pharmacokinetics and Drug Metabolism, Amgen Inc., 1120 Veterans Boulevard, South San Francisco, California, 94080, United States; Departments of Therapeutic Discovery, and ⊥Oncology Research, Amgen Inc., One Amgen Center Drive, Thousand Oaks, California 91320, United States; Departments of Therapeutic Discovery, and ∇Pharmaceutics, Amgen Inc., 360 Binney Street, Cambridge, Massachusetts 02142, United States Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology, the NMPA and State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences & the Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, China Department of Hematology The First Affiliated Hospital, Zhejiang University School of Medicine Hangzhou China Beijing National Laboratory for Molecular Sciences Key Laboratory of Organic Solids Institute of Chemistry Chinese Academy of Sciences Beijing 100190 P. 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China Department of Biostatistics, School of Public Health, Cheeloo College of Medicine Shandong University Jinan Shandong People's Republic of China 1Radiation Oncology, Departments of Department of Medicine, Columbia Center for Human Development and Stem Cell Therapies, Columbia Stem Cell Initiative, Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center , New York, NY 10032, USA Department of Pharmacology Tongji University School of Medicine 1239 Siping Road Shanghai 200092 China Department of Clinical Pharmacy, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Engineering and Technology Research Center for Pediatric Drug Development, Shandong Medicine and Health Key Laboratory of Clinical Pharmacy, Jinan, Shandong Province, China; Beijing National Laboratory for Molecular Sciences, Key Laboratory of Organic Solids Institute of Chemistry Chinese Academy of Sciences Beijing 100190 P. R. China Natural Products Research Center, Chengdu Institute of Biology, Chinese Academy of Science, Chengdu 610041, P. R. China Department of General Surgery Qilu Hospital of Shandong University Jinan China Jiangsu Center for Drug Screening China Pharmaceutical University 24 Tong Jia Xiang Nanjing 210009 China Guangzhou University of Chinese Medicine, Guangzhou 510405, China Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun Center of Mass Spectrometry, Changchun 130022, China. Department of Hematology the First Affiliated Hospital Zhejiang University College of Medicine Hangzhou China; Key Laboratory of Hematologic Malignancies, Diagnosis and Treatment, Zhejiang Hangzhou China State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, 130012 Changchun, China From the Department of Plastic and Reconstructive Surgery, Shanghai Ninth People’s Hospital, Shanghai JiaoTong University School of Medicine; the Department of Plastic and Reconstructive Surgery, Xiangya Changde Hospital; and the Division of Plastic Surgery, University of California, Davis. Department of Urology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, P.R. China Department of Gastroenterology the First Affiliated Hospital of Nanchang University Nanchang China Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Jiangxi Province clinical ophthalmology Institute and Oculopathy Research Centre, Nanchang, Jiangxi, China (mainland) Cancer Epigenetics Laboratory, Department of Clinical Oncology, State Key Laboratory of Oncology in South China, Sir YK Pao Center for Cancer and Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong and CUHK Shenzhen Research Institute, Hong Kong Pain Medicine Center and Department of Orthopedics, Peking University Third Hospital, Beijing, China. Department of Preventive Medicine, School of Medicine, Hunan Normal University, Changsha 410013, China. Department of Clinical Pharmacy, The First Affiliated Hospital of Shandong First Medical University, Jinan, China Key Laboratory of the Ministry of Education for Advanced Catalysis Materials; Zhejiang Normal University; Jinhua 321004; China Center for Molecular Biology of Oral Diseases, University of Illinois at Chicago, Chicago, IL; Ruijin Hospital, School of Medicine Shanghai Jiaotong University Shanghai China Key Laboratory of Nonferrous Metals Chemistry and Resources Utilization of Gansu Province State Key Laboratory of Applied Organic Chemistry and College of Chemistry and Chemical Engineering Lanzhou University Lanzhou 730000 P. R. China Department of Biochemistry and Molecular Biology, Wannan Medical College, Wuhu, China St. Jude Children's Research Hospital The Key Laboratory of Dairy Science of Education Ministry, Life College, Northeast Agricultural University Harbin China Eye and ENT Hospital, Shanghai Medical College, Fudan University, Shanghai, China; and; Shanghai Key Laboratory of Visual Impairment and Restoration, Fudan University, Shanghai, China. Department of Food Science and Engineering Institute of Food Safety and Nutrition, Jinan University Guangzhou China MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage School of Chemistry & Chemical Engineering Harbin Institute of Technology (HIT) Harbin 150001 China Key Laboratory for Supramolecular Structure and Materials of Ministry of Education, Jilin University, Changchun 130012, People's Republic of China Beijing National Laboratory for Molecular Science CAS Key Laboratory of Colloid and Interface and Thermodynamics CAS Research/Education Center for Excellence in Molecular Sciences Institute of Chemistry Chinese Academy of Sciences Beijing 100190 China; School of Chemistry and Chemical Engineering University of Chinese Academy of Sciences Beijing 100049 China State Key Laboratory of Polymer Materials Engineering, Polymer Research Institute of Sichuan University, Chengdu 610065, China School of Information Science and Technology Nantong University Nantong China Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu 610041, China, and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China Pfizer Oncology, San Diego, California, USA Institute of Cardiovascular Diseases, The First Affiliated Hospital of Dalian Medical University, Dalian, China Department of Urology Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China Department of Hematology, the First Affiliated Hospital, College of Medicine Zhejiang University Hangzhou China; Institute of Hematology, Zhejiang University Hangzhou China; Zhejiang Province Key Laboratory of Hematology Oncology Diagnosis and Treatment Hangzhou China Departments of †Medicinal Chemistry; ‡Pharmacokinetics and Drug Metabolism; §Oncology Research; and ∥Molecular Structure, Amgen Inc., 360 Binney Street, Cambridge, Massachusetts 02142, United States Research Center for Differentiation and Development of Basic Theory of Traditional Chinese Medicine (TCM), Jiangxi University of TCM, Nanchang 330004, China. University of Minnesota Cancer Center and Department of Pediatrics, Minneapolis, MN 55455 Beijing Institute of Ratiation Medicine, Department of Biotechnology Department of Clinical Pharmacy Shandong Provincial Qianfoshan Hospital, The First Affiliated Hospital of Shandong First Medical University 16766 Jingshi Road Jinan Shandong 250014 China Department of Cardiology, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, People’s Republic of China; Clinical Trials Center, Cardiovascular Research Foundation 1Musculoskeletal Tumor Center, Department of Orthopedics, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, P.R. China. Department of Plastic Surgery, The Affiliated Friendship Plastic Surgery Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, China Natural Products Research Center, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, P. R. China; Hongyun Biotech Co., Ltd., Nanjing, Jiangsu 211112, China Department of Cardiology Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China; Cardiovascular Key Laboratory of Zhejiang Province, Hangzhou, China Normandie Université, COBRA, UMR 6014 et FR 3038, Université de Rouen, INSA Rouen, CNRS, 1 rue Tesnière, 76821 Mont Saint-Aignan Cedex, France Cardiovascular Key Laboratory of Zhejiang Province; The 2nd Affiliated Hospital, College of Medicine, Zhejiang University; Hangzhou 310009 China Plastic Surgery Hospital Peking Union Medical College and Chinese Academy of Medical Science Beijing China Key National Laboratory of Solid State Microstructures Collaborative Innovation Center of Advanced Microstructures Jiangsu Key Laboratory of Artificial Functional Materials College of Engineering and Applied Sciences Nanjing University Nanjing 210093 P. R. China CAS Key Laboratory of Colloid and Interface Science, Institute of Chemistry, CAS, 100080 Beijing, P.R. China, and Technical Institute of Physics and Chemistry, CAS, 100101 Beijing, P.R. China The Ludwig Center for Cancer Genetics and Therapeutics, Howard Hughes Medical Institute and Sidney Kimmel Cancer Center at the Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China Department of Evolutionary Anthropology, University of Vienna; Human Evolution and Archaeological Sciences (HEAS), University of Vienna State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou 510060, China; Department of Hepatobiliary Oncology, Sun Yat-sen University Cancer Center, Guangzhou 510060, China Department of Pediatric and Preventive Dentistry, Affiliated Hospital of Stomatology, Nanjing Medical University, Nanjing 210029, China National Engineering Laboratory for Clean Technology of Leather Manufacture Sichuan University Chengdu 610065 P. R. China; Department of Biomass Chemistry and Engineering Sichuan University Chengdu 610065 P. R. China Laboratory of Plant Nematology and Research Center of Nematodes of Plant Quarantine, Department of Plant Pathology/Guangdong Province Key Laboratory of Microbial Signals and Disease Control, College of Agriculture, South China Agricultural University, Guangzhou, People’s Republic of China Department of Orthopedics, Huashan Hospital, Fudan University, Shanghai 200040, P.R. China Division of Surgical Research, Department of Surgery, Brown University School of Medicine/Rhode Island Hospital, 593 Eddy Street, Providence, RI 02903; and National Engineering Research Center of Industrial Crystallization Technology, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China Shenzhen Institute of Guangdong Ocean University, Shenzhen 518120, China; School of Mechanical Engineering, Guangdong Ocean University, Zhanjiang 524088, China Department of Hematology, The First Affiliated Hospital Zhejiang University School of Medicine Hangzhou Zhejiang People's Republic of China; Zhejiang Provincial Key Laboratory of Hematologic Malignancy Zhejiang University Hangzhou Zhejiang People's Republic of China; Zhejiang Provincial Clinical Research Center for Hematological Disorders Hangzhou Zhejiang People's Republic of China; Zhejiang University Cancer Center Hangzhou Zhejiang People's Republic of China Department of Plastic and Reconstructive Surgery, Shanghai Ninth People’s Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, 200011, China Beijing National Laboratory for Molecular Science; CAS Key Laboratory of Colloid and Interface and Thermodynamics; CAS Research/Education Center for Excellence in Molecular Sciences; Institute of Chemistry; Chinese Academy of Sciences Pfizer Inc, San Diego, CA, USA Department of Ophthalmology, Jiangxi Provincial People’s Hospital, Nanchang Department of Biochemistry and Molecular Biology, Medical College of Shantou University, Shantou 515041, PR China. State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang, Jiangxi, 330047, China Department of Nephrology the First Hospital of China Medical University Shenyang China Department of Dermatology and Venereology Shanghai Tongji Hospital Tongji University School of Medicine Shanghai China College of Ecological Environment and Urban Construction; Fujian University of Technology; Fuzhou 350118; China Department of Chemistry and Center for Atomic Engineering of Advanced Materials, School of Materials Science and Engineering, Anhui Province Key Laboratory of Chemistry for In-organic/Organic Hybrid Functionalized Materials, Anhui University, Hefei, Anhui 230601, P. R. China School of Chemistry & Chemical Engineering, Nanchang University, Nanchang 330031, People’s Republic of China Ultra-high Speed Communication Laboratory Department of Chemistry Research and Discovery; ‡Department of Pharmacokinetics and Drug Metabolism; §Oncology Research; ∥Department of Molecular Structure; ⊥Bioassay and Profiling; and ∇Protein Technologies, Amgen Inc., 360 Binney Street, Cambridge, Massachusetts 02142, United States Department of Ophthalmology, First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, China College of Chemistry and Molecular Engineering; Zhengzhou University; Henan; China 450001 Flexible Electronics Research Center, State Key Laboratory of Digital Manufacturing Equipment and Technology, School of Mechanical Science and Engineering, Huazhong University of Science and Technology, Wuhan, Hubei 430074, China. Department of Hematology, The First Affiliated Hospital, Zhejiang University College of Medicine, Hangzhou, Zhejiang�310003, P.R. China Shanghai East Hospital, The Institute for Biomedical Engineering & Nano Science, Tongji University School of Medicine, Shanghai, China; Exploratory Statistics, AbbVie, North Chicago, Illinois; Development Sciences, AbbVie, North Chicago, Illinois Department of Pharmaceutical Engineering, China Pharmaceutical University, Nanjing 211198, China International S&T Cooperation Base of Chiral Chemistry, Henan University, Kaifeng 475004, Henan, P. R. China Department of Ophthalmology, Eye & ENT Hospital of Fudan University, Shanghai, China; Shanghai Key Laboratory of Visual Impairment and Restoration, Science and Technology Commission of Shanghai Municipality, Shanghai, China Department of Dermatology, Hunan Key Laboratory of Medical Epigenomics, The Second Xiangya Hospital, Central South University, Changsha, China; Research Unit of Key Technologies of Immune-Related Skin Diseases Diagnosis and Treatment, Chinese Academy of Medical Sciences (2019RU027), Changsha, China From the Department of Cell Differentiation, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto, Japan; The 21st Century COE “Cell Fate Regulation Research and Education Unit,” Kumamoto University, Kumamoto, Japan; the Division of Pulmonary Biology, Children's Hospital Medical Center, Cincinnati, OH; and the Institute for Biomedical Research, The Medical School, Birmingham University, Birmingham, United Kingdom. State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, China Department of Hematology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China; Key Laboratory of Hematologic Malignancies, Diagnosis and Treatment, Hangzhou, Zhejiang Province, China; Institute of Hematology, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China Department of Chemistry; Capital Normal University; Beijing 100048, China Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi, China; Department of Ophthalmology, The People's Hospital of Hubei Province, Wuhan 430060, Hubei, China Department of Orthopaedics, the Fourth Medical Center, Chinese PLA General Hospital-Fourth Medical Center, Beijing 100148, China. School of Science, China University of Geosciences, Beijing 100083, China Department of Pharmaceutical Engineering, School of Engineering, China Pharmaceutical University, Nanjing 210009, China Institute of Industrial Science The University of Tokyo 4-6-1 Komaba, Meguro-ku Tokyo 153-8505 Japan Division of Surgical Oncology, Department of Surgery, The University of Tennessee Health Science Center, Memphis, TN 38163, USA Key Laboratory of Drug-Targeting and Drug Delivery System of the Ministry of Education, West China School of Pharmacy, Sichuan University, Chengdu 610041, China From the Memorial Sloan-Kettering Cancer Center, New York, NY; Baylor Sammons Cancer Center-Texas Oncology, PA, Dallas, TX; Massachusetts General Hospital Cancer Center, Boston, MA; Cleveland Clinic Taussig Cancer Center, Cleveland, OH; Johns Hopkins University, Baltimore, MD; Vanderbilt University, Nashville, TN; University of Wisconsin Paul P. Carbone Comprehensive Cancer Center, Madison, WI; Seattle Cancer Care Alliance, Seattle, WA; Pfizer Global Research and Development, La Jolla; City of Hope... Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Colloid, Interface and Chemical Thermodynamics, CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China; School of Chemistry Engineering, University of Chinese Academy of Sciences, Beijing 100049, China Department of Physics, Washington State University, 2710 University Drive, Richland, Washington 99354, and W. R. Wiley Environmental Molecular Sciences Laboratory and Chemical Sciences Division, Pacific Northwest National Laboratory, P.O. Box 999, Richland, Washington 99352 School of Stomatology of Qingdao University, Qingdao, Shandong 266003, P.R. China Department of Physiology and Cell Biology, The Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH 43221, USA Department of Cognitive Science, Beijing Institute of Basic Medical Science, Beijing 100850, China. Division of Pediatric Blood and Marrow Transplantation,; Masonic Cancer Center,; Center for Immunology,; Center for Genome Engineering, Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Colloid and Interface Science, Institute of Chemistry, CAS, 100080, Beijing, P. R. China Department of Ophthalmology, Eye and ENT Hospital, Shanghai Medical College, Fudan University, Shanghai, China.; Shanghai Key Laboratory of Visual Impairment and Restoration, Fudan University, Shanghai, China. Department of Epidemiology and Biostatistics, School of Medicine, Hunan Normal University, Changsha, China Department of Ophthalmology, Eye & ENT Hospital of Fudan University, Shanghai, People's Republic of China; and; Shanghai Key Laboratory of Visual Impairment and Restoration, Fudan University, Shanghai, People's Republic of China. 1 Department of Nephrology, The First Hospital of China Medical University , Shenyang , Liaoning Province , China . China National Center for Biotechnology Development, Beijing 100039, China. Pfizer La Jolla San Diego CA U.S.A. Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China Department of Cardiovascular Medicine, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, China Departments of Medicinal Chemistry; ‡Pharmacokinetics and Drug Metabolism; §Oncology Research; and ∥Molecular Structure, Amgen Inc., 360 Binney Street, Cambridge, Massachusetts 02142, United States Key Laboratory of Nonferrous Metals Chemistry and Resources Utilization of Gansu Province; State Key Laboratory of Applied Organic Chemistry and College of Chemistry and Chemical Engineering; Lanzhou University; Lanzhou 730000; China National Engineering Research Center of Industrial Crystallization Technology; School of Chemical Engineering and Technology; Tianjin University; Tianjin 300072; China Florey Institute of Neuroscience and Mental Health; University of Melbourne; Parkville Victoria Australia Centre for Protolife Research and Centre for Organized Matter Chemistry School of Chemistry, University of Bristol Bristol BS8 1TS UK School of Applied and Engineering Physics, Cornell University, Ithaca, New York 14853, United States Jiangsu Key Laboratory for Biodiversity & Biotechnology and Jiangsu Key Laboratory for Aquatic Crustacean Diseases, College of Life Sciences, Nanjing Normal University, Nanjing, China Department of Brain Protection and Plasticity Institute of Basic Medical Sciences Beijing 100850 China Authors' Affiliations: 1Pfizer Global Research and Development, New York, New York, 2Premiere Oncology, Santa Monica, California, 3Pfizer Global Research and Development, La Jolla, California, and 4St. John's Hospital, Santa Monica, California School of Materials Science and Engineering, Beihang University, Beijing 100083, China Jiangsu Center for Drug Screening, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, China; Key Laboratory of Drug Quality Control & Pharmacovigilance, China Pharmaceutical University, Nanjing, China Department of Cardiology, The First Affiliated Hospital of Nanchang University, Nanchang 330008, China; Department of Cardiology, The First Hospital of Nanchang, The Third Affiliated Hospital of Nanchang University, Affiliated Hospital of Sun Yat-sen University, Nanchang 330008, China From the Dana-Farber Cancer Institute; Massachusetts General Hospital; Beth Israel Deaconess Medical Center, Boston, MA; University of Southern California Norris Comprehensive Cancer Center, Los Angeles; University of California, San Francisco Comprehensive Cancer Center, San Francisco; Pfizer Global Research and Development, La Jolla, CA; Fox Chase Cancer Center, Philadelphia, PA; University of Alabama, Birmingham, AL; and Washington University, St Louis, MO Chemistry Research and Discovery, Amgen, Inc., One Kendall Square, Cambridge Massachusetts 02139 Department of Chemistry, Zhejiang University, Hangzhou 310027, People’s Republic of China School of Food Science & Technology; Jiangnan University; Wuxi; 214122 China Department of Otolaryngology, Peking University Shenzhen Hospital, Shenzhen, China Department of Hematology School of Medicine the First Affiliated Hospital Zhejiang University Hangzhou China College of Food Science and Engineering; Shanxi Agricultural University; Taigu; P. R. China Institute of Molecular Medicine (IMM) Shanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine Renji Hospital School of Medicine Shanghai Jiao Tong University Shanghai 200127 P. R. China Institute of Bioinformatics and Institute of Crop Science College of Agriculture and Biotechnology Zhejiang University Hangzhou China Department of Pharmaceutics, Guangdong Provincial Key Laboratory of New Drug Screening, State Key Laboratory of Organ Failure Research, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China and From the Oregon Health and Science University Cancer Institute and Portland Veterans Affairs Medical Center, Portland, OR; Memorial Sloan-Kettering Cancer Center, New York, NY; Dana-Farber Cancer Institute, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA; and Pfizer Global Research and Development, La Jolla, CA Department of Chemistry, Fuzhou University, Fuzhou, Fujian 350108, P. R. China; Fujian Provincial Key Laboratory of Theoretical and Computational Chemistry, Xiamen, Fujian 361005, P. R. China Department of Preventive Dentistry The First Affiliated Hospital of Harbin Medical University Harbin China Department of Medicinal Chemistry, Department of HTS and Molecular Pharmacology and Department of Molecular Structure, One Kendall Square, Building 1000, Cambridge, Massachusetts 02139, and Department of Inflammation, Department of Pharmaceutics, and Department of Pharmacokinetics and Drug Metabolism, Amgen, Inc., One Amgen Center Drive, Thousand Oaks, California 91320-1799 Department of Hematology, Key Laboratory of Hematologic Malignancies, Diagnosis and Treatment, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China College of Stomatology Southern Medical University Guangzhou China; Department of Stomatology Nanfang Hospital Southern Medical University Guangzhou China Department of Anatomy/Embryology School of Basic Medical Sciences, Peking University, Beijing, China 2Key Laboratory on Machine Perception (Ministry of Education), Peking University, Beijing, China 3Key Laboratory for Visual Impairment and Restoration (Mi Departments of †Medicinal Chemistry, ‡Molecular Structure, §Lead Discovery, ∥Hematology/Oncology Research, ⊥Molecular Sciences and Computational Biology, and #Pharmacokinetics and Drug Metabolism, Amgen, Inc., 360 Binney Street, Cambridge, Massachusetts 02142, 1120 Veterans Boulevard, South San Francisco, California 94080, and One Amgen Center Drive, Thousand Oaks, California 91320, United States Department of Hematology, The First Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang Province, People's Republic of China; Institute of Hematology, Zhejiang University, Zhejiang Province, People's Republic of China; Key Laboratory of Hematology, Diagnosis and Treatment, Zhejiang Province, People's Republic of China Department of Pharmacy The First Affiliated Hospital of Shandong First Medical University/Shandong Province Qianfoshan Hospital Jinan P. R. China Department of Emergency & Critical Care Center, Beijing Anzhen Hospital Capital Medical University Beijing China Department of Biochemistry and Molecular Biology Laboratory, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu 610041, China. Jiangsu Key Laboratory of Biofunctional Material, School of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, P. R. China Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China Xin Huang, Wang-Di Liao, Xiao-Lin Pan, You-Xiang Chen, Nong-Hua Lv, Xuan Zhu, Department of Gastroenterology, First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China. State Key Laboratory of Polymer Materials Engineering, College of Polymer Science and Engineering, Sichuan University, 610065 Chengdu, China; Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China. Department of Electrical and Computer Engineering; National University of Singapore; 117583 Singapore; Centre for Advanced 2D Materials and Graphene Research Centre; National University of Singapore Department of Anesthesiology West China Hospital of Sichuan University Chengdu China Department of Epidemiology, School of Medicine, Hunan Normal University, Changsha, Hunan, China Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China Institute of HematologyMedical College, Jinan University, Guangzhou, PR China; and Department of Hematology, Guangdong General Hospital (Guangdong Academy of Medical Sciences), Guangzhou, PR China MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage School of Chemistry and Chemical Engineering Harbin Institute of Technology Harbin 150001 China Department of Hematology, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, School of Medicine, South China University of Technology, Guangzhou, Guangdong, P. R. China College of Pharmacy, Nanjing University of Chinese Medicine; Nanjing People's Republic of China Institute of Clinical Virology, The Second Hospital of Anhui Medical University Hefei China Department of Ophthalmology, Jiangxi Provincial People’s Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang 330006, Jiangxi, China Department of Chemistry, Fuzhou University, Fuzhou, Fujian 350108, People’s Republic of China, and State Key Laboratory of Structural Chemistry, Fuzhou, Fujian 350002, People’s Republic of China Molecular Structure & Characterization, Amgen, Inc., Cambridge, Massachusetts 02139, United States Department of Cognitive sciences Beijing Institute of Basic Medical Sciences Beijing China Department of Hematology, The First Affiliated Hospital Zhejiang University School of Medicine Hangzhou China; Zhejiang Provincial Key Laboratory of Hematopoietic Malignancy Zhejiang University Hangzhou China; Zhejiang Provincial Clinical Research Center for Hematological Disorders Hangzhou China; Zhejiang University Cancer Center Hangzhou China Department of Biomedical Sciences, City University of Hong Kong, Hong Kong 999077, P. R. China Joint International Research Laboratory of Atmospheric and Earth System Sciences, School of Atmospheric Sciences, Nanjing University, 210023 Nanjing, China; School of Public Health and Management, Research Center for Medicine and Social Development, Collaborative Innovation Center of Social Risks Governance in Health Chongqing Medical University Chongqing China Department of Ophthalmology, Jiangxi Provincial People’s Hospital, Nanchang, China Department of Obstetrics and Gynecology West China Second University Hospital of Sichuan University Chengdu China aDepartment of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 Research and Development Bristol‐Myers Squibb Company Pennington New Jersey School of Automation, Chongqing University of Posts and Telecommunications, Chongqing 400065, China Department of Chemistry, Fuzhou University, Fuzhou, Fujian 350108, P. R. China; Fujian Provincial Key Laboratory of Theoretical and Computational Chemistry, Xiamen 361005, P. R. China Department of Urology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, P.R. China From the Clinical Trials Center, Cardiovascular Research Foundation, New York, NY (B.R., P.G., T.M., X.H., A.M., G.W., R.M., A.J.K., G.W.S.); Center for Interventional Vascular Therapy, Division of Cardiology, NewYork-Presbyterian Hospital/Columbia University Medical Center (J.D., A.M., G.W., A.J.K., G.W.S.); Gagnon Cardiovascular Institute, Morristown Medical Center, NJ (P.G.); Hôpital du Sacré-Coeur de Montréal, Université de Montréal, Quebec, Canada (P.G.); Department of Cardiology and Pneumology... College of Chemistry and Life Sciences, Zhejiang Normal University, Jinhua 321004, China College of Pipeline and Civil Engineering, China University of Petroleum (East China), Qingdao 266580, China Department of Cardiology, First Affiliated Hospital, Ion Channel Disease Laboratory, Key Laboratory of Environment and Genes Related to Diseases of Education Ministry, Medical School of Xi'an Jiaotong University, Xi'an 710061, China. hearthx@126.com College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou, Henan 450001, China Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Science, Beijing 100700, China Department of Anesthesia Authors' Affiliations: 1Dana-Farber Cancer Institute, Boston, Massachusetts; 2H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida; 3University Hospitals Leuven, Leuven Cancer Institute, Catholic University Leuven, Leuven, Belgium; 4Ohio State University Comprehensive Cancer Center, Columbus, Ohio; 5Erasmus University Medical Centre, Rotterdam, The Netherlands; 6Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland; 7Duke University Medical Center, Durham, North Carolina; 8Hospital de la Santa Creu i Sant Pau, Barcelona, Spain; 9Institut Gustave-Roussy, Villejuif, France; 10UNSW Prince of Wales Clinical School, Randwick, Australia; 11Instituto de Biomedicina de Sevilla (IBIS), Seville and Hospital Universitario Doce de Octubre, Madrid, Spain; 12University Claude Bernard Lyon I, Centre Léon Bérard, Lyon, France; 13Peter MacCallum Cancer Centre, Melbourne, Australia; 14Columbia University, New York, New York; 15Pfizer Oncology, La Jolla, California; and 16Istituto Nazionale Tumori, Mil Key Laboratory of Luminescence and Optical Information, Beijing Jiaotong University Ministry of Education, Beijing 100044, China National Engineering Laboratory for Crop Efficient Water Use and Disaster Mitigation Key Laboratory of Dryland Agriculture and Key Laboratory for Prevention and Control of Residual Pollution in Agricultural Film Ministry of Agriculture and Rural Affairs Beijing China; Institute of Environment and Sustainable Development in Agriculture Chinese Academy of Agricultural Sciences Beijing China School of Life Sciences, Institute of Aquatic Economic Animals and Guangdong Provincial Key Laboratory for Aquatic Economic Animals, National Engineering Center for Marine Biotechnology of South China Sea, Sun Yat-Sen University, Guangzhou, Guangdong 510275, P. R. China School of Medicine, Southern University of Science and Technology, Shenzhen, Guangdong, China Department of Biochemistry and Molecular Biology, West China School of Preclinical and Forensic Medicine and State Key Laboratory of Oral Diseases, Sichuan University School of Textiles Zhongyuan University of Technology No. 41 Zhongyuan Road (M) Zhengzhou 450007 China St. Jude Children's Research Hospital, MEMPHIS, Tennessee, United States College of Mechanical Engineering; Chengdu University; Chengdu; P.R. China Cornell High Energy Synchrotron Source; Cornell University; Ithaca; USA; School of Applied and Engineering Physics College of Pipeline and Civil Engineering, China University of Petroleum (East China), Qingdao 266580, PR China Department of Chemistry Research and Discovery, Amgen Inc., One Kendall Square, Building 1000, Cambridge, Massachusetts 02139, Department of Chemistry Research and Discovery, Department of Inflammation, Department of Pharmaceutics, and Department of Pharmacokinetics & Drug Metabolism, Amgen Inc., One Amgen Center Drive, Thousand Oaks, California 91320, and Evotec OAI, 151 Milton Park, Abingdon, Oxon OX14 4SD, UK College of Marine Science and Engineering, Nanjing Normal University, 1 Wenyuan Road, Nanjing, Jiangsu 210023, People's Republic of China Natural Products Research Center, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, Sichuan 610041, People's Republic of China Department of Cardiology, the First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, Shaanxi, China Ultra-High Speed Communication Laboratory Department of Rehabilitation Medicine, Physiotherapy and Occupational Therapy Divisions, Shenzhen Hospital, The University of Hong Kong, Shenzhen, China Center for Translational Medicine at The First Affiliated Hospital, School of Forensic Sciences, School of Pharmacy, Xi'an Jiao Tong University Health Science Center, Xi'an, Shaanxi, People's Republic of China Department of Ultrasound Imaging, Renmin Hospital of Wuhan University, Wuhan, China College of Ocean Food and Biological Engineering, Fujian Provincial Key Laboratory of Food Microbiology and Enzyme Engineering, Jimei University, Xiamen, 361021, China Laboratory of Molecular Recognition and Synthesis; Department of Chemistry; Zhejiang University; Hangzhou 310027; P. R. China Department of Polymer Science & Engineering; School of Chemistry and Chemical Engineering; Nanjing University; Nanjing 210023; P. R. China Department of Chemistry, Fuzhou University, Fuzhou, Fujian 350108, P. R. China, State Key Laboratory of Structural Chemistry, Fuzhou, Fujian 350002, P. R. China, and Department of Chemistry, Brown University, Providence, Rhode Island 02912 Department of Hematology, The First Affiliated Hospital Zhejiang University School of Medicine Zhejiang P.R. China; Zhejiang Provincial Key Laboratory of Hematopoietic Malignancy Zhejiang University Hangzhou P.R. China; Zhejiang University Cancer Center Hangzhou P.R. China; Zhejiang Provincial Clinical Research Center for Hematological Disorders Hangzhou P.R. China Department of Hematology the First Affiliated Hospital College of Medicine Zhejiang University Zhejiang China; Institute of Hematology Zhejiang University Zhejiang China; Zhejiang Province Key Laboratory of Hematology Oncology Diagnosis and Treatment Hangzhou China Department of Medicine, Columbia Center for Human Development, Columbia Stem Cell Initiative, Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY 10032, USA. Department of Hematology, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China; Department of Psychology, University of Chinese Academy of Sciences, Beijing, China Key Laboratory of Nonferrous Metals Chemistry and Resources Utilization of Gansu Province State Key Laboratory of, Applied Organic Chemistry and, College of Chemistry and Chemical Engineering Lanzhou University Lanzhou 730000 P. R. China Departments of Biological Sciences and Human Genetics, University of Pittsburgh and the University of Pittsburgh Cancer Institute, Pittsburgh, PA 15260; and Institute of Pathology, University-Hospital Charite, D-10098 Berlin, Germany Leibniz Institute of Polymer Research Dresden, Hohe Strasse 6, 01069 Dresden, Germany Department of Pharmacology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing100191, China; Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, State Key Laboratory of Natural and Biomimetic Drugs, NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Peking University, Beijing100191, China; Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery Systems, Beijing100191, China Beijing Key Laboratory of Photoelectronic/Electrophotonic Conversion Materials Key Laboratory of Cluster Science Ministry of Education Advanced Technology Research Institute (Jinan) Frontiers Science Center for High Energy Material School of Chemistry and Chemical Engineering Beijing Institute of Technology No. 5, South Street, Zhongguancun, Haidian District Beijing 100081 China Department of Hematology Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University Guangzhou China Department of Cardiology, West China Hospital and West China School of Nursing, Sichuan University, Chengdu, Sichuan, China. Email: huangsanjin1234@163.com. State Key Laboratory of Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Science, Lanzhou, China Pfizer La Jolla CA USA Department of Medicinal Chemistry, Department of Molecular Structure, and Department of HTS and Molecular Pharmacology, Amgen Inc., One Kendall Square, Building 1000, Cambridge, Massachusetts 02139, and Department of HTS and Molecular Pharmacology, Department of Inflammation, Department of Pharmaceutics, and Department of Pharmacokinetics and Drug Metabolism, Amgen, Inc., One Amgen Center Drive, Thousand Oaks, California 91320-1799 School of Computer Science, Hunan University of Technology, Zhuzhou, China Solar activity Prediction Center, National Astronomical Observatories, Chinese Academy of Sciences, Beijing, China. Department of Clinical Pharmacy The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital Jinan China Department of Thoracic Surgery, People's Hospital of Dongxihu District Wuhan 430040, Hubei, China. Pediatric Blood and Marrow Transplantation, University of Minnesota Medical School, Minneapolis, MN 55455.; Masonic Cancer Center, University of Minnesota Medical School, Minneapolis, MN 55455.; Center for Immunology, University of Minnesota Medical School, Minneapolis, MN 55455.; Center for Genome Engineering, University of Minnesota Medical School, Minneapolis, MN 55455. School of Chemistry & Chemical Engineering; Nanjing University; Nanjing; P. R. China 3Pfizer Global Research and Development, Ann Arbor, Michigan; and Department of Ophthalmology Department of Ophthalmology, Jiangxi Provincial People’s Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, Jiangxi, China Department of Computer Science & Engineering Dalian University of Technology Dalian 116024 China Department of Obstetrics The First Affiliated Hospital of Jinzhou Medical University Jinzhou Liaoning China Engineering Research Center of Ministry of Education for Fine Chemicals, and College of Chemistry and Chemical Engineering; Shanxi University; Taiyuan; China Department of Ophthalmology, Eye and Ear Nose Throat Hospital of Fudan University, Shanghai, China;; Shanghai Key Laboratory of Visual Impairment and Restoration, Fudan University, Shanghai, China;; NHC Key Laboratory of Myopia, Fudan University, Key Laboratory of Myopia, Chinese Academy of Medical Sciences, Shanghai, China; and CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, P.R. China; Department of Psychology, University of Chinese Academy of Sciences, Beijing, P.R. China Eye Center, Wuhan University Renmin Hospital, Wuhan University, Wuhan, China Bristol-Myers Squibb Research and Development, Hopewell, NJ, USA Department of Dermatology, Hunan Key Laboratory of Medical Epigenomics, The Second Xiangya Hospital of Central South University, Changsha, China Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, School of Public Health, Tongji Medical College Huazhong University of Science and Technology Wuhan People's Republic of China; Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College Huazhong University of Science and Technology Wuhan People's Republic of China Department of Pediatrics, The Cancer Center, University of Minnesota, Minneapolis, MN, USA. State Key Laboratory of Supramolecular Structure and Materials, Jilin University, Changchun 130012, People’s Republic of China Laboratory of Molecular Recognition and Synthesis; Department of Chemistry; Zhejiang University; Hangzhou 310027; People's Republic of China Guangxi Key Laboratory of Electrochemical Energy Materials, School of Chemistry and Chemical Engineering, Guangxi University, Nanning, Guangxi 530004, China Natural Products Research Center, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, Sichuan 610041, P.R. China College of Life Sciences Jiangsu Key Laboratory for Biodiversity and Biotechnology Nanjing Normal University Nanjing China State Key Laboratory of Experimental Hematology National Clinical Research Center for Blood Diseases Institute of Hematology and Blood Diseases Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Tianjin China SunYat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, China MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage; State Key Laboratory of Urban Water Resource and Environment; School of Chemistry and Chemical Engineering; Harbin Institute of Technology; Harbin Department of Plastic and Reconstructive Surgery, Ninth People’s Hospital, Medical School of Shanghai Jiao Tong University, 639 Zhizaoju Road, Shanghai 200011, China College of Chemistry; Fuzhou University; Fuzhou; P. R. China; Fujian Provincial Key Laboratory of Theoretical and Computational Chemistry Department of Nutrition and Food Hygiene, School of Public Health, Central South University,Changsha 410078, China. f55842@163.com Pfizer Oncology New York NY USA Department of Medicine, Columbia Center for Human Development, Columbia University Irving Medical Center, New York, NY 10032, USA School of Public Health, Hebei Medical University, Shijiazhuang 050017, China. Beijing National Laboratory for Molecular Science CAS Key Laboratory of Colloid and Interface and Thermodynamics CAS Research/Education Center for Excellence in Molecular Sciences Institute of Chemistry Chinese Academy of Sciences Beijing 100190 P.R. China; School of Chemistry and Chemical Engineering University of Chinese Academy of Sciences Beijing 100049 P.R. China Southeast University; Ministry of Education Showa Pharmaceutical University, Higashi-tamagawagakuen, Machida, Tokyo 194-8543, Japan, and Division of Pharmaceutical Sciences, Graduate School of Natural Science and Technology, Kanazawa University, Kanazawa 920-1192, Japan Department of Molecular Engineering, Amgen Research, Amgen Inc, Cambridge, United States Key Laboratory of Drug-Targeting and Drug Delivery System of Education Ministry, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu 610041, China, and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands;; Department of Pathology, Health Science Center, Peking University, Beijing, China; Department of Hematology, Guangdong General Hospital and Guangdong Academy of Medical Sciences, Guangzhou, P.R. China. Authors' Affiliations: 1Magee-Womens Research Institute, Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine; 2Women's Cancer Research Center, 3Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh and Biostatistics Facility, University of Pittsburgh Cancer Institute; 4Magee-Womens Hospital, University of Pittsburgh Medical Center, Pittsburgh; 5Division of Gynecologic Oncology; Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania; and 6Biostatistics/Epidemiology/Research Design (BERD) Core, Center for Clinical and Translational Sciences, The University of Texas Health Science Center, Houston, Texas; Authors' Affiliations: 1Magee-Womens Research Institute, Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine; 2Women's Cancer Research Center, 3Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh and Biostatistics Facility, University of Pittsburgh Cancer Institute; 4Magee-Womens Hospital, University of Pittsburgh Medical Center, Pittsburgh; 5Division of Gynecologic Oncology; Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania; and 6Biostatistics/Epidemiology/Research Design (BERD) Core, Center for Clinical and Translational Sciences, The University of Texas Health Science Center, Houston, Texas Department of Ophthalmology, First Affiliated Hospital of Nanchang University, Jiangxi Province Clinical Ophthalmology Institute and Oculopathy Research Centre, Nanchang, Jiangxi Province, China; Department of Ophthalmology, First People’s Hospital of Jiujiang City, Jiujiang, Jiangxi Province, China State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Sun Yat‐sen University Cancer Center Guangzhou 510060 China; Department of Hepatobiliary Oncology Sun Yat‐sen University Cancer Center Guangzhou 510060 China State Key Laboratory of Pollution Control and Resource Reuse, Tongji University, Shanghai 200092, China. Department of General Practice Medicine, Shengjing Hospital of China Medical University, Shenyang 110022, China; Department of Nephrology, The First Affiliated Hospital of China Medical University, Shenyang 110000, China Department of Plastic and Reconstructive Surgery Shanghai Ninth People’s Hospital, Shanghai JiaoTong University School of Medicine 639 Zhizaoju Road, 200011 Shanghai, People’s Republic of China Department of Ophthalmology, Jiangxi Provincial People’s Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, China Department of Hematology, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, People’s Republic of China Department of Dermatology, Shanghai Tongji Hospital, Tongji University School of Medicine, Shanghai, P.R. China College of Management, Gansu Agricultural University, Lanzhou 730070, China. College of Medicine, University of Tennessee Health Science Center, Memphis, TN, USA Geriatric Cardiology Department of the Second Medical Center and National Clinical Research Center for Geriatric Diseases, Chinese People's Liberation Army General Hospital, Beijing 100089, China; Medical School of People's Liberation Army General Hospital, Beijing 100089, China Department of Plastic Surgery, the Affiliated Friendship Plastic Surgery Hospital of Nanjing Medical University Department of Medicinal Chemistry, ‡Department of Molecular Structure and Characterization, §Therapeutic Innovation Unit, Amgen Inc., 360 Binney Street, Cambridge, Massachusetts 02142, United States Department of Orthopedics Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China Department of Food Science and Engineering, Institute of Science and Technology, Jinan University, Guangzhou 510632, China Department of Nutrition and Food Hygiene School of Public Health Hebei Province Key Laboratory of Environment and Human Health Hebei Medical University Shijiazhuang China Normandie Univ, INSA Rouen, UNIROUEN, CNRS, COBRA (UMR 6014), 76000 Rouen, France Center of Hepatopancreatobiliary Diseases, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University Key Laboratory of Optoelectronic Materials Chemistry and Physics, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou 350002, China State Key Laboratory of Oncology in South China, 651 Dongfeng Road East, Guangzhou, 510060, People's Republic of China; Department of Gynecologic Oncology, Sun Yat-sen University Cancer Center, 651 Dongfeng Road East, Guangzhou, 510060, People's Republic of China Clinical Trials Center, Cardiovascular Research Foundation, New York, NY, USA; Division of Cardiology, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China Key Laboratory of Cancer Prevention and Intervention China National Ministry of Education, Key Laboratory of Molecular Biology in Medical Science 2nd Affiliated Hospital, Zhejiang University Hangzhou 310009 China School of Public Health, Li Ka Shing Faculty of Medicine The University of Hong Kong Hong Kong Hong Kong China Department of Ultrasound Imaging Wuhan University Renmin Hospital Wuhan China Zhejiang University, College of Medicine, The First Affiliated Hospital, Department of Neurosurgery, Hangzhou, China. The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei‐MOST KLOS) & Key Laboratory for Oral Biomedical Engineering of Ministry of Education (KLOBME) School & Hospital of Stomatology, Wuhan University Wuhan China Natural Products Research Center, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, People’s Republic of China From the Division of Blood and Marrow Transplantation, Department of Pediatrics; the Department of Genetics, Cell Biology and Development, University of Minnesota Cancer Center, Minneapolis, MN; and the Department of Pathology and Laboratory Medicine, the Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA. Department of Radiotherapy, The Affiliated Changzhou Second People’s Hospital of Nanjing Medical University, Changzhou Second People’s Hospital, Changzhou Medical Center, Nanjing Medical University , Changzhou , Jiangsu, 213000 , China Key National Laboratory of Solid State Microstructures, Collaborative Innovation Center of Advanced Microstructures, Nanjing University, Nanjing 210093, P. R. China Rice Research Institute, Sichuan Agricultural University, 211, Huimin Road, Wenjiang District, Chengdu 611130, China Department of Neurosurgery, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou City, China Department of Anesthesiology, The Affiliated People's Hospital of Ningbo University, Ningbo, Zhejiang 315040, P.R. China Research Center for Medicine and Social Development, Innovation Center for Social Risk Governance in Health, School of Public Health and Management, Chongqing Medical University, Chongqing 400016, China. zhouli_tj@163.com. Department of Surgery, Division of Surgical Research, the Alpert School of Medicine at Brown University/Rhode Island Hospital, Providence, Rhode Island Authors' Affiliations: 1Ludwig Center at Dana-Farber/Harvard Cancer Center; 2Dana-Farber Cancer Institute; 3Harvard Medical School; 4Brigham and Women's Hospital; 5Children's Hospital, Boston, Massachusetts; 6Portland VA Medical Center; 7Oregon Health and Science University Knight Cancer Institute, Portland, Oregon; 8Memorial Sloan-Kettering Cancer Center, New York, New York; and 9Pfizer Oncology, La Jolla, California The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei‐MOST KLOS) & Key Laboratory of Oral Biomedicine Ministry of Education (KLOBME) School & Hospital of Stomatology Wuhan University Wuhan China Department of Chemistry, Zhejiang Normal University, 688 Yingbin Road, Jinhua 321004, China Department of Dermatology, Shanghai Tongji Hospital, Tongji University School of Medicine, Shanghai, China Laboratory of Molecular Recognition and Synthesis, Department of Chemistry, Zhejiang University, Hangzhou 310027, Zhejiang People’s Republic of China State Key Laboratory of Digital Manufacturing Equipment and Technology, Flexible Electronics Research Center, School of Mechanical Science and Engineering, Huazhong University of Science and Technology, Wuhan, China. Authors' Affiliation: Magee-Womens Research Institute, Department of OB/GYN & Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania Jiangsu Center for Pharmacodynamics Research and Evaluation, China Pharmaceutical University, Nanjing 210009, China; Key Laboratory of Drug Quality Control and Pharmacovigilance, China Pharmaceutical University, Nanjing 210009, China Hepatopancreatobiliary Center, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University Beijing China Department of Pharmacy, Clinical Trial Center, Shandong Provincial Qianfoshan Hospital The First Affiliated Hospital of Shandong First Medical University Jinan Shandong China School of Environment and Chemical Engineering, Shanghai University, Shanghai 200444, China. huangxin_china@163.com Pfizer Oncology, San Diego, CA. State Key Lab of New Ceramics and Fine Processing, School of Materials Science and Engineering, Tsinghua University, Beijing 100084, China Fuzhou University 1 College of Chemistry, , Fuzhou, Fujian 350116, China; Fujian Provincial Key Laboratory of Theoretical and Computational Chemistry 2 , Xiamen, Fujian 361005, China Department of Preventive Medicine The Medicine School of Hunan Normal University Changsha China Beijing Key Laboratory of Environmental Toxicology, Department of Toxicology and Sanitary Chemistry, School of Public Health, Capital Medical University, Beijing 100069, PR China Department of Ophthalmology and Vision Science, Eye and ENT Hospital, Fudan University, Shanghai, People's Republic of China; and; Key Laboratory of Myopia of State Health Ministry, and Key Laboratory of Visual Impairment and Restoration of Shanghai, Shanghai, People's Republic of China. State Key Laboratory of Polymer Materials Engineering Polymer Research Institute Sichuan University Chengdu 610065 China Research Center for Air Pollution and Health, Institute of Environmental Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China From the Memorial Sloan-Kettering Cancer Center, New York, NY; Premiere Oncology, Santa Monica; University of California, San Francisco; Pfizer Global Research and Development, La Jolla; University of Southern California, Los Angeles, CA; Lombardi Cancer Center, Washington, DC; Oncology Hematology of Kansas City, Kansas City, MO; Duke University Medical Center, Durham, NC; University of Colorado Cancer Center, Aurora, CO; University of Pennsylvania, Philadelphia, PA; Vanderbilt University Medical Center,... Department of Radiation Biology Beijing Key Laboratory for Radiobiology Beijing Institute of Radiation Medicine Beijing China School of Chemistry and Chemical Engineering; Nanjing University; Jiangsu 210023; China Department of Dermatology The Second Xiangya Hospital, Central South University Changsha Hunan 410011 China Department of Breast Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. Department of Pharmacy, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, China Department of Physics, Washington State University, 2710 University Drive, Richland, Washington 99354, Chemical Sciences Division, Pacific Northwest National Laboratory, P.O. Box 999, Richland, Washington 99352, School of Chemistry, The University of Melbourne, Parkville, Victoria, Australia, 3010, and the Bio21 Molecular Science and Biotechnology Institute, 30 Flemington Road, Parkville, Victoria, Australia 3010 Heilongjiang Provincial Key Laboratory of Polymeric Composition Materials; School of Materials Science and Engineering, Qiqihar University, Qiqihar, 161006, P. R. China Hefei Institute of Intelligent Machines, Chinese Academy of Sciences, P.O. Box 1130, Hefei, Anhui 230031, China. International Research Center for Environmental Membrane Biology, Foshan University, Foshan , Guangdong , China Department of Hematology Guangdong Provincial People's Hospital/Guangdong Academy of Medical Sciences Guangzhou China Department of Assisted Reproduction Shanghai First Maternity and Infant Hospital Tongji University School of Medicine Shanghai China Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction, Ministry of Education, Key Laboratory of Swine Genetics and Breeding, Ministry of Agriculture, College of Animal Science and Technology, Huazhong Agricultural University , Wuhan, Hubei 430070, PR China Southwest University/Chinese Academy of Agricultural Sciences Citrus Research Institute, , Beibei, Chongqing 400712, China School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong , 7 Sassoon Road, Southern District, Hong Kong SAR , China National Space Science Center, Chinese Academy of Sciences, Beijing 100190, China Institute of Crop Science and Institute of Bioinformatics College of Agriculture and Biotechnology Zhejiang University Hangzhou China Department of General Surgery, Xi’an Central Hospital, Xi’an Jiaotong University, Xi’an, China Department of Hematology, The First Affiliated Hospital, College of Medicine Zhejiang University Hangzhou PR China; Zhejiang Provincial Key Lab of Hematopoietic Malignancy Zhejiang University Hangzhou PR China; Institute of Hematology Zhejiang University Hangzhou PR China Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, Beijing 100083, People’s Republic of China Department of Pharmacy, The First Affiliated Hospital of Shandong First Medical University, Jinan, China; Department of Clinical Pharmacy, School of Pharmaceutical Sciences, Shandong University, Jinan, China 6Department of Human Genetics, University of Pittsburgh Graduate School of Public Health, Oral Cancer Center at the University of Pittsburgh, Pittsburgh, Pennsylvania Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, China Beijing National Laboratory for Molecular Sciences, Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China Frontiers Science Center for High Energy Material Advanced Technology Research Institute (Jinan) Beijing Key Laboratory of Photoelectronic/Electrophotonic Conversion Materials Key Laboratory of Cluster Science School of Chemistry and Chemical Engineering Beijing Institute of Technology Beijing 100081 P. R. China State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Wuhan 430079, China; Department of Periodontology, School & Hospital of Stomatology, Wuhan University, Wuhan 430079, China Department of Thoracic Surgery, First Affiliated Hospital of Anhui Medical University, Hefei 230032, China Department of Traditional Chinese Medicine, Chongqing Medical University, Chongqing, China (mainland) Department of Immunology, Second Military Medical University, Shanghai, China. Collaborative Innovation Center of Chemical Science and Engineering (Tianjin) National Engineering Research Center of Industrial Crystallization Technology School of Chemical Engineering and Technology Tianjin University Tianjin 300072 P. R. China MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage State Key Laboratory of Urban Water Resource and Environment School of Chemistry and Chemical Engineering Harbin Institute of Technology Harbin 150001 China Department of Orthopaedics The Second Affiliated Hospital of Zhejiang University School of Medicine Hangzhou China; Orthopedics Research Institute of Zhejiang University Hangzhou China Department of Urology, Shanghai JiaoTong University School of Medicine, Ruijin Hospital, Shanghai, China Department of Physics, Washington State University, 2710 University Drive, Richland, Washington 99354, W. R. Wiley Environmental Molecular Sciences Laboratory and Chemical Sciences Division, Pacific Northwest National Laboratory, MS K8-88, Post Office Box 999, Richland, Washington 99352, and Department of Chemistry and Biochemistry, Utah State University, Logan, Utah 84322 MOE Key Laboratory of Environmental Remediation and Ecosystem Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China The Ludwig Center for Cancer Genetics and Therapeutics at the Johns Hopkins Kimmel Comprehensive Cancer Center, Baltimore, Maryland Hunan Provincial Key Laboratory for Synthetic Biology of Traditional Chinese Medicine, School of Pharmaceutical Sciences, Hunan University of Medicine, Huaihua, PR China Department of Oral and Maxillofacial Surgery, Faculty of Stomatology, Capital University of Medical Sciences, Beijing 100050, China. huangxin_291@hotmail.com Department of Geriatrics, Qilu Hospital of Shandong University, Jinan, China Department of Chemistry, Anhui University, 230601 Hefei, Anhui, PR China Discovery and Exploratory Statistics, AbbVie Inc., North Chicago, IL, USA Department of Orthopedics, Union Jiangbei Hospital (the People's Hospital of Caidian), Wuhan, Hubei, China. Department of Dermatology Second Xiangya Hospital Hunan Key Laboratory of Medical Epigenomics Central South University Changsha China School of Pharmacy, Anhui Medical University, Hefei 230032, P. R. China Beijing Key Laboratory for Radiobiology, Department of Radiation Biology, Beijing Institute of Radiation Medicine, Beijing 100850, China Department of Breast Surgery, Peking Union Medical College Hospital Beijing, China. Department of Ultrasuond Renmin Hospital of Wuhan University Wuhan Hubei China Center on Aging Psychology, Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100101, China Key Laboratory of the Ministry of Education for Advanced Catalysis Materials; Zhejiang Normal University; China Qingdao University, China Shandong Qianfuo Mountain Hospital, Jinan, Shandong, China Huazhong University of Science and Technology, Wuhan, People’s Republic of China Department of Chemistry; Zhejiang University; Hangzhou 310027, P. R. China Division of Pediatric Blood and Marrow Transplantation, University of Minnesota, Minneapolis, MN 55455.; The Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455.; Center for Immunology, University of Minnesota, Minneapolis, MN 55455.; Center for Genome Engineering, University of Minnesota, Minneapolis, MN 55455. Cornell High Energy Synchrotron Source (CHESS), Cornell University, Ithaca, New York 14853, United States Key Laboratory of Drinking Water Science and Technology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, Beijing 100083, China Eye Center, Renmin Hospital of Wuhan University, Wuhan, Hubei, China Faculty of Geography, Yunnan Normal University, Kunming 650500, China. Oncology, Nanjing Hospital of Chinese Medicine, Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Nanjing 210000, Jiangsu, China Institute of Molecular Medicine (IMM), Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China; Institute of Nanochemistry and Nanobiology, Shanghai University, Shanghai 200444, China Department of Gastroenterology, Traditional Cinese Medicine Hospital of Yinchuan, Yinchuan, Ningxia, China School of Chemistry and Chemical Engineering, Guangxi University, 530004 Nanning, Guangxi, People's Republic of China Department of Ultrasound Renmin Hospital of Wuhan University Wuhan China Department of Brain Protection and Plasticity, Institute of Basic Medical Sciences, Beijing 100850, China. Department of Cognitive Sciences Institute of Basic Medical Sciences Beijing China College of Marine Technology and Environment, Dalian Ocean University, Dalian, PR China; Key Laboratory of Nearshore Marine Environmental Science and Technology in Liaoning Province, Dalian Ocean University, Dalian, PR China Department of Obstetrics, Gynecology and Reproductive Sciences University of Pittsburgh School of Medicine Pittsburgh Pennsylvania; Division of Gynecological Oncology Magee‐Womens Research Institute Pittsburgh Pennsylvania Department of Cardiology, First Affiliated Hospital of Xi’an Jiaotong University Health Science Center, Ion Channel Disease Laboratory, Key Laboratory of Environment and Genes related to Diseases of Education Ministry, Xi’an, Shaanxi 710061, P.R. China State Key Laboratory of Drug Research & Center of Pharmaceutics Shanghai Institute of Materia Medica Chinese Academy of Sciences 501 Haike Road Shanghai 201203 China; School of Pharmacy University of Chinese Academy of Sciences Beijing 100049 China The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei‐MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology Wuhan University Wuhan China Key Laboratory of Western China's Environmental Systems(Ministry of Education), College of Earth and Environmental Sciences, Lanzhou University, Lanzhou 730000, China. State Key Laboratory of Lake Science and Environment, Nanjing Institute of Geography and Limnology, Chinese Academy of Sciences, Nanjing 210008, China. Reproductive Medical Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China. Beijing National Laboratory for Molecular Sciences Key Laboratory of Organic Solids Institute of Chemistry Chinese Academy of Sciences Beijing 100190 P. R. China; School of Chemistry and Chemical Engineering University of Chinese Academy of Sciences Beijing 100049 P. R. China From the Institute of Cancer Research and Royal Marsden Hospital, London (N.C.T.); David Geffen School of Medicine at University of California, Los Angeles, Santa Monica (D.J.S.), and Pfizer Oncology, San Diego (X.H.) — both in California; National Cancer Center, Goyang-si, Gyeonggi-do (J.R.), and Seoul National University Hospital, Cancer Research Institute, Seoul National University College of Medicine, Seoul (S.-A.I.) — both in South Korea; Dnipropetrovsk Medical Academy, City Multiple-Discipline... Department of Neurosurgery, Affiliated Jiangyin Hospital of Nantong University, Nantong University, Jiangyin, Wuxi, China Pediatric Blood and Marrow Transplantation,; Masonic Cancer Center,; Center for Immunology,; Center for Genome Engineering, and Department of Clinical Pharmacy The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital Jinan China Department of Extraction Engineering Technological Research, Nanjing Normal University, Jiangsu - China Natural Products Research Center Chengdu Institution of Biology; University of Chinese Academy of Science; Chengdu; P.R. China Key Laboratory of Nonferrous Metals Chemistry and Resources Utilization of Gansu Province and State Key Laboratory of Applied Organic Chemistry; College of Chemistry and Chemical Engineering; Lanzhou University; Lanzhou 730000; P. R. China The Howard Hughes Medical Institute and the Ludwig Center for Cancer Genetics and Therapeutics, Johns Hopkins Kimmel Comprehensive Cancer Center, Baltimore, MD 21231, USA. Department of Hematology, The First Affiliated Hospital Zhejiang University School of Medicine Hangzhou Zhejiang People's Republic of China; Zhejiang Provincial Key Laboratory of Hematopoietic Malignancy Zhejiang University Hangzhou Zhejiang People's Republic of China; Zhejiang Provincial Clinical Research Center for Hematological Disorders Hangzhou Zhejiang People's Republic of China; Zhejiang University Cancer Center Hangzhou Zhejiang People's Republic of China Molecular Structure Department of Chemistry, Zhejiang University, Hangzhou 310027, China Nanjing University of Posts and Telecommunications Jilin Ginseng Academy, Changchun University of Chinese Medicine, Changchun 130117, PR China School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam Road, Hong Kong SAR, China Department of Nutrition and Food Hygiene, School of Public Health, Hebei Medical University, Hebei Key Laboratory of Environment and Human Health, Shijiazhuang, People’s Republic of China; Handan Center for Disease Control and Prevention, Handan, People’s Republic of China Department of Obstetrics and Gynaecology West China Second University Hospital of Sichuan University Chengdu Sichuan China; Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University) Ministry of Education, West China Second University Hospital of Sichuan University Chengdu Sichuan China College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310032, China Co‐Innovation Center for Sustainable Forestry in Southern China College of Forestry Nanjing Forestry University Nanjing China; Jiangsu Key Laboratory for Prevention and Management of Invasive Species Nanjing Forestry University Nanjing China Department of Therapeutic Discovery, Amgen Inc., 360 Binney Street, Cambridge, Massachusetts 02142, United States |
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