http://rdf.ncbi.nlm.nih.gov/pubchem/author/MD5_58be1250076f9d2c073cdd6ea981264c
Outgoing Links
Predicate | Object |
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family-name | Zhang Xu Zhang |
name | Xu Zhang |
given-name | Xu |
organization-name | Department of Stem Cell Biology, Atomic Bomb Disease Institute Nagasaki University Nagasaki Japan College of Food Science and Engineering Jilin University Changchun China Affiliated Eye Hospital of Nanchang University, Jiangxi Research Institute of Ophthalmology & Visual Sciences, Nanchang 330006, China. Email: xuzhang19@163.com. Liaoning Blood Center, Shenyang, Liaoning 110044, P. R. China. ljp_63@yahoo.com. Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province and Division of Histology and Embryology, Department of Anatomy, Xuzhou Medical College (JFW), Xuzhou, Jiangsu Province, People's Republic of China Institute of Brain‐Intelligence Technology Zhangjiang Lab, Shanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai Center of Brain‐Intelligence Engineering Shanghai China State Key Laboratory of Bioactive Substance and Function of Natural Medicines; Institute of Materia Medica; Chinese Academy of Medical Sciences and Peking Union Medical College; Beijing 100050; People's Republic of China Department of Urology, The General Hospital of the People's Liberation Army, Beijing 100039, China. Department of Otorhinolaryngology Head and Neck Surgery Beijing TongRen Hospital, Capital Medical University Beijing China; Beijing Key Laboratory of Nasal Diseases Beijing Institute of Otolaryngology Beijing China School of Biomedical Engineering Capital Medical University Beijing China; Beijing Key Laboratory of Fundamental Research on Biomechanics in Clinical Application Capital Medical University Beijing China National and Local Joint Engineering Research Center of Targeted and Innovative Therapeutics, Chongqing Engineering Laboratory of Targeted and Innovative Therapeutics, Chongqing Key Laboratory of Kinase Modulators as Innovative Medicine, Chongqing Collaborative Innovation Center of Targeted and Innovative Therapeutics, College of Pharmacy & IATTI, Chongqing University of Arts and Sciences, Chongqing 402160, China School of Chinese Materia Medica Nanjing University of Chinese Medicine Nanjing Jiangsu 210023 China. Central Laboratory, Xuanwu Hospital, Capital Medical University, Key Laboratory for Neurodegenerative Disease of Ministry of Education, Beijing Geriatric Medical Research Center, No. 45 Changchun Street, Xicheng District, Beijing 100053, China Division of Clinical and Translational Sciences, Department of Internal Medicine Department of Urology, Chinese PLA General Hospital, Beijing, China. School of Medical Science and Laboratory Medicine, Jiangsu University, Zhenjiang, Jiangsu 212013, P. R. China School of Biological Science & Medical Engineering, Southeast University Institute of New Energy Material Chemistry, School of Materials Science and Engineering, Renewable Energy Conversion and Storage Center, Nankai University, Tianjin 300350, P. R. China School of Science Jiangxi University of Science and Technology Ganzhou 341000 China Biological Sciences Division and Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, P.O. Box 999, Richland, Washington 99352, Department of Molecular and Medical Pharmacology, UCLA School of Medicine, P.O. Box 951735, Los Angeles, California 90095, and National Centre for Adult Stem Cell Research, Griffith University, Nathan, Queensland, 4111, Australia Key Laboratory of Chemical Sensing & Analysis in Universities of Shandong; School of Chemistry and Chemical Engineering; University of Jinan; Jinan; P. R. China Department of Physics and Astronomy; California State University; USA Department of Physiology and Pathophysiology, Peking University Health Science Center, Beijing, China;; Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China; UIC Department of Pancreatic Surgery, Fudan University Shanghai Cancer CenterShanghai 200032, China. Department of Oncology, Shanghai Medical College, Fudan UniversityShanghai 200032, China. Department of Chemistry and Key Laboratory of Organic Synthesis of Jiangsu Province, Soochow University, Suzhou 215123, People's Republic of China Department of Internal Medicine The University of Texas Health Science Center Houston TX USA; Center for Clinical and Translational Sciences The University of Texas Health Science Center Houston TX USA State Key Laboratory of Grassland Agro‐Ecosystems, College of Ecology Lanzhou University Lanzhou China National Center for Liver Cancer Shanghai 201805 China College of Food Science and Technology, Shanghai Ocean University, Shanghai 201306, People’s Republic of China; Laboratory of Quality and Safety Risk Assessment for Aquatic Products on Storage and Preservation (Shanghai), Ministry of Agriculture, Shanghai 201306, People’s Republic of China Institute of Electronic Engineering, China Academy of Engineering Physics, Mianyang, 621900, China State Key Laboratory of Kidney Disease, Department of Urology, Chinese People’s Liberation Army Medical Academy, Chinese People’s Liberation Army General Hospital, Beijing, China Department of Gastroenterology Chongqing University Cancer Hospital Chongqing China Department of Physics and Astronomy, California State University Northridge, Northridge, California 91330-8268, United States Department of Stem Cell Biology, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki 852-8523, Japan; Department of Stem Cell Biology, Nagasaki University Graduate School of Biomedical Sciences, 1-12-4 Sakamoto, Nagasaki 852-8523, Japan Department of Urology/State Key Laboratory of Kidney Diseases, Chinese People’s Liberation Army (PLA) General Hospital, Beijing, China (mainland) Department of Anesthesiology and Intensive Care, Changhai Hospital, Second Military Medical University, Shanghai, China (mainland) School of Physics, Huazhong University of Science and Technology, Wuhan 430074, China, Wuhan Center for Magnetic Resonance, State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan 430071, China, and Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, Singapore 117543 California State University 2 Department of Physics and Astronomy, , Northridge, California 91330-8268, USA Operating room of the Suizhou Central Hospital, Suizhou, Hubei, China Department of Pathophysiology, School of Basic Medical Sciences Harbin Medical University Harbin China State Key Laboratory of Magnetic Resonance and Atomic Molecular Physics, Key Laboratory of Magnetic Resonance in Biological Systems, National Center for Magnetic Resonance in Wuhan, Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences, Wuhan 430071, China; University of Chinese Academy of Sciences, Beijing 100049, China Department of Medical Records, First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Heilongjiang, China Central Laboratory, Renmin Hospital of Wuhan University, Wuhan, China Department of Anesthesiology, The First Affiliated Hospital of Guangxi Medical University Heilongjiang Center for Disease Control and Prevention, Harbin, China Tianjin Key Laboratory of Metabolic Diseases, Key Laboratory of Immune Microenvironment and Disease-Ministry of Education, Department of Physiology and Pathophysiology, Collaborative Innovation Center of Tianjin for Medical Epigenetics, Tianjin Medical University, Tianjin 300070, China. Pharmaceutical College, Lanzhou University, Lanzhou 730000, China. zhangxucq@126.com Brain Hospital Affiliated Hospital of Xuzhou Medical College Xuzhou Jiangsu China; Insititute of Nervous System Diseases Xuzhou Medical College Xuzhou Jiangsu China Key Laboratory of Rubber-Plastics, Ministry of Education/Shandong Provincial Key Laboratory of Rubber-Plastics, School of Polymer Science and Engineering, Qingdao University of Science & Technology, Qingdao 266042, China Jiangsu Province Key Lab of Human Functional Genomics, Department of Biochemistry and Molecular Biology, Nanjing Medical University, Nanjing 210029, China Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine (TCM) Prevention and Treatment of Tumor, Nanjing University of Chinese Medicine, Nanjing 210023, China Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, 510120 Guangdong, China; Sino-French Hoffmann Institute, Guangzhou Medical University, Guangzhou, 510120 Guangdong, China; Institute of Human Virology, Key Laboratory of Tropical Disease Control of Ministry of Education, Guangdong Engineering Research Center for Antimicrobial Agent and Immunotechnology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong, China Department of Gastrointestinal Surgery, Affiliated Zhongshan Hospital of Dalian University, Dalian 116001, Liaoning Province, China Key Laboratory of Environment and Genes Related to Diseases, Ministery of Education, Xi'an Jiaotong University, Xi'an 710061, China. Department of Biomedical Engineering the Ohio State University 1080 Carmack Road Columbus OH 43210 USA Translational Neuroscience Center, Graduate School of Medicine, International University of Health and Welfare , Okawa, Japan School of Chemical Engineering, Zhengzhou University, Zhengzhou 450001, P. R. China Department of Electrical Engineering and Computer Sciences Massachusetts Institute of Technology Cambridge MA 02139 USA Nanjing Drum Tower Hospital Clinical College of Jiangsu University, Nanjing, 210008, China Institute of Advanced Battery Materials and Devices, Faculty of Materials and Manufacturing, Beijing University of Technology, Beijing, 100124, People’s Republic of China; Key Laboratory of Advanced Functional Materials, Ministry of Education, Beijing University of Technology, Beijing, 100124, People’s Republic of China Guangdong Engineering Research Center for Light and Health, Guangzhou Higher Education Mega Center Guangdong Pharmaceutical University Guangzhou China; Guangdong Provincial Key Laboratory of Pharmaceutical Bioactive Substances, Guangzhou Higher Education Mega Center Guangdong Pharmaceutical University Guangzhou China Department of Head and Neck Thyroid, The Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, China Department of Oral Anatomy and Physiology, State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi Key Laboratory of Stomatology, School of Stomatology The Fourth Military Medical University Xi'an China; Department of Stomatology the Fourth Hospital of Harbin Medical University Harbin China Transfusion Medicine Institute, Liaoning Blood Center Shenyang Liaoning China; Liaoning Provincial Key Laboratory for Blood Safety Research Shenyang Liaoning China From the Tianjin Key Laboratory of Metabolic Diseases, Key Laboratory of Immune Microenvironment and Disease—Ministry of Education, Department of Physiology and Pathophysiology, Collaborative Innovation Center of Tianjin for Medical Epigenetics, Tianjin, Medical University, China (L.Y., J.H., B.L., M.Y., H.W., M.L., X.L., H.L., X.Z., Y.Z., D.A.) From the State Key Laboratory of Oncology in South China and Sun Yat-sen University Cancer Center, Guangzhou, People's Republic of China. Beijing Institute of Technology; Ministry of Industry and Information Technology Division of Clinical and Translational Sciences Department of Internal Medicine The University of Texas Health Science Center at Houston McGovern Medical School Houston TX USA Center for Biostatistics and Bioinformatics University of Mississippi Medical Center Jackson, Mississippi College of Chemistry and Molecular Sciences; Wuhan University; Wuhan, P. R. China The State Key Laboratory of Reproductive Medicine, Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China Department of Urology, PLA General Hospital Beijing People's Republic of China; State Key Laboratory of Kidney Diseases, PLA General Hospital Beijing People's Republic of China College of Life Science, Huaibei Normal University, Huaibei, P.R. China State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China Department of Neurology Chinese PLA General Hospital Beijing 100853 China Department of Cardiac Surgery, The General Hospital of Northern Theater Command, Shenyang, Liaoning 110000, China State Key Laboratory of Polymer Materials Engineering Polymer Research Institute of Sichuan University Chengdu 610065 China Department of Thoracic Surgery, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Esophageal Cancer Institute, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China MOE Key Laboratory of Organic OptoElectronics and Molecular Engineering, Department of Chemistry, Tsinghua University, Beijing 100084, People’s Republic of China Nuclear Medicine Department, General Hospital of Tibet Military Area Command, Lhasa, Tibet Autonomous Region 850000, P.R. China Department of Basic Medicine, Harbin Medical University, Harbin, China Tianjin Key Laboratory of Ionic‐Molecular Function of Cardiovascular Disease Department of Cardiology Tianjin Institute of Cardiology Second Hospital of Tianjin Medical University Tianjin China Department of Urology, People's Liberation Army General Hospital, Military Postgraduate Medical College, Beijing, People's Republic of China Institute of Cancer Research and Department of Gynecology Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine Shanghai 200071 P. R. China Tianjin Key Laboratory of Metabolic Diseases Department of Physiology and Pathophysiology Tianjin Medical University Tianjin China; Collaborative Innovation Center of Tianjin for Medical Epigenetics Tianjin Medical University Tianjin China Division of Clinical and Translational Sciences, Department of Internal Medicine, McGovern Medical School The University of Texas Health Science Center at Houston Houston Texas USA; Biostatistics/Epidemiology/Research Design (BERD) component, Center for Clinical and Translational Sciences (CCTS) The University of Texas Health Science Center at Houston Houston Texas USA MOE Key Lab of Environment and Health School of Public Health Tongji Medical College Wuhan PRC Department of Oral Maxillofacial-Head Neck Oncology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai, China Holtom-Garrett Program in Neuroimmunology, Department of Neurology 1 , 2 , 3 , and 4; Department of Radiology 1 , 2 , 3 , and 4; Department of Biostatistics 1 , 2 , 3 , and 4; Graduate Program in Immunology, University of Michigan, Ann Arbor, MI 48109 1 , 2 , 3 , and 4 Department of Urology, PLA General Hospital, Beijing 100853, China. *Corresponding author, E-mail: xzhang@foxmail.com. Department of Biotechnology; Dalian Institute of Chemical Physics; Chinese Academy of Sciences; Dalian; China Key Laboratory of Laboratory Medicine of Jiangsu Province, The Affiliated Hospital, Jiangsu University, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu, People's Republic of China Department of Urology, Chinese PLA General Hospital/Chinese PLA Medical Academy/State Key Laboratory of Kidney Diseases, Beijing, P.R. China. Department of Neurology, Fujian Provincial Hospital, Fujian Medical University, Fuzhou 350001, China Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, United States Section of Hematology/Oncology, Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612 School and Hospital of Stomatology, Tianjin Medical University, 12 Observatory Road, Tianjin 30070, P.R. China Institute of Human Virology, Key Laboratory of Tropical Disease Control of Ministry of Education, Guangdong Engineering Research Center for Antimicrobial Agent and Immunotechnology, Zhongshan School of Medicine, Sun Yat-sen University, 510080, Guangzhou, Guangdong, China; Key Laboratory of Medical Science and Laboratory Medicine of Jiangsu Province, School of Medicine Jiangsu University 301 Xuefu Road Zhenjiang Jiangsu 212013 China Department of Urology Surgery, People's Liberation Army General Hospital, Beijing 100083, China. Email: xzhang@foxmail.com. Key Laboratory for Special Functional Materials; Henan University; Kaifeng 475004, P. R. China National Engineering Research Center for Beijing Biochip Technology Sub‐center in Ningxia General Hospital of Ningxia Medical University Yinchuan China Department of Microbiology and Immunology, School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230026, People's Republic of China Department of Gastroenterology, Huzhou First People's Hospital Huzhou 313000, Zhejiang Province, P. R. China. College of Furniture and Art Design, Central South University of Forestry and Technology, Changsha 410004, Hunan, China; Green Furniture Engineering Technology Research Center, National Forestry & Grassland Administration, Changsha 410004, Hunan, China; Green Home Engineering Technology Research Center in Hunan, Changsha 410004, Hunan, China Key Laboratory of Bovine Disease Control in Northeast China of Ministry of Agriculture and Rural affairs of the People's Republic of China, College of Animal Science and Veterinary Medicine Heilongjiang Bayi Agricultural University Daqing China College of Life Sciences; Hunan Provincial Key Laboratory of Microbial Molecular Biology - State Key Laboratory Breeding Base of Microbial Molecular Biology; Hunan Normal University; Changsha China University of Science and Technology of China (USTC), Hefei, China National Center for Liver Cancer Shanghai China Department of Vascular Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China Sickle Cell Center, Department of Medicine, University of Illinois at Chicago, Chicago, IL; National University of Defense Technology, College of Artificial Intelligence 1 , Changsha, Hunan 410073, China; National University of Defense Technology, Interdisciplinary Center for Quantum Information 2 , Changsha, Hunan 410073, China Beijing Institute of Technology University of the Chinese Academy of Sciences, Beijing 100049, China; Beijing National Laboratory for Condensed Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing 100190, China Asad Bashey, Connie A. Sizemore, Karen Manion, Stacey Brown, H. Kent Holland, Lawrence E. Morris, and Scott R. Solomon, Northside Hospital; and Xu Zhang, Georgia State University, Atlanta, GA. Tianjin Key Laboratory of Function and Application of Biological Macromolecular Structures School of Life Sciences Tianjin University Tianjin 300072 P. R. China Key Laboratory of Luminescence Analysis and Molecular Sensing (Southwest University); Ministry of Education; College of Pharmaceutical Sciences; Southwest University; Chongqing 400715 State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China Department of Urology, State Key Laboratory of Kidney Diseases, Chinese PLA General Hospital, Beijing, People’s Republic of China; School of Medicine, Nankai University, Tianjin, People’s Republic of China State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine, Jilin University, Changchun 130062, China The Institute for Advanced Studies (IAS) College of Chemistry and Molecular Sciences Wuhan University Wuhan 430072 Hubei P. R. China Tianjin Key Laboratory of Metal and Molecule Based Material Chemistry, Key Laboratory of Advanced Energy Materials Chemistry (Ministry of Education), Computational Centre for Molecular Science, Institute of New Energy Material Chemistry, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), School of Materials Science and Engineering, National Institute for Advanced Materials, Nankai University, Tianjin 300353, P. R. China Key Laboratory of Medical Science and Laboratory Medicine of Jiangsu Province, School of Medicine Jiangsu University Zhenjiang Jiangsu P. R. China University of Leeds, Leeds, U.K. State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National Center for Magnetic Resonance in Wuhan, Wuhan Institute of Physics and Mathematics, Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences−Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan 430071, China; University of Chinese Academy of Sciences, Beijing 10049, China Shenzhen Key Laboratory of Reproductive Immunology for Peri‐implantation Fertility Center Shenzhen Zhongshan Urology Hospital Shenzhen China; Shenzhen Zhongshan Institute for Reproductive Medicine and Genetics Shenzhen China College of Food and Pharmaceutical Engineering, Guiyang University, Guiyang 550005, China Institute of Neuroscience and State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China; University of Chinese Academy of Sciences, Shanghai, China; School of Life Science and Technology, ShanghaiTech University, Shanghai, China Department of Hand Surgery, The Third Affiliated Hospital of Hebei Medical University, Shijiazhuang, Hebei; and School of Mathematical Sciences South China Normal University Guangzhou Guangdong China Department of Physics and Astronomy, California State University Northridge, California 91330-8268, United States School of Pharmacy, Chengdu University of Traditional Chinese Medicine Chengdu 611137, China. School of Flexible Electronics (Future Technologies) & Institute of Advanced Materials (IAM), Key Laboratory of Flexible Electronics (KLOFE), Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing Tech University (NanjingTech), Nanjing 211816, China Contribution from the Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, and Keck Interdisciplinary Surface Science Center, NUANCE, Northwestern University, Evanston, Illinois 60208-3108 Harbin Medical University, Harbin 150028, Heilongjiang Province, China College of Life Science, Liaoning Normal University, Dalian 116029, China. Department of Physics and Astronomy California State University Northridge CA USA Department of Entomology Nanjing Agricultural University Nanjing China Department of Head Neck and Thyroid The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital Zhengzhou China Tsinghua-Peking Center for Life Sciences and Department of Pharmacology and Pharmaceutical Sciences, School of Medicine, Tsinghua University, Beijing 100084, People's Republic of China Department of Thorax, Cancer Center, Sun Yat-sen University, Guangzhou 510060, China. Ottawa Institute of Systems Biology and Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, Ontario K1H 8M5, Canada Department of Ultrasound, The 2nd Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China Beijing Key Lab for Source Control Technology of Water Pollution, Beijing Forestry University, Beijing 100083, China California State University Northridge Department of Physics and Astronomy, , Northridge, California 91330-8268, USA Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research (Ministry of Education), Key Laboratory of Phytochemistry R&D of Hunan Province, and Key Laboratory of the Assembly and Application of Organic Functional Molecules of Hunan Province, Institute of Interdisciplinary Studies, College of Chemistry and Chemical Engineering, Hunan Normal University, 410081 Changsha, P. R. China Department of Physics and Astronomy, California State University, Northridge, Northridge, CA 91330, USA. Department of Nuclear Medicine, Sun Yat-sen University Cancer Canter, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China 1State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, P.R. China. School of Pharmacy, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China Department of Oncology, Shengjing Hospital of China Medical University Department of Urology, The Third Medical Center, Chinese PLA General Hospital Guangdong Provincial Key Laboratory of Functional Supramolecular Coordination Materials and Applications, College of Chemistry and Materials Science, Jinan University, Guangzhou 510632, China Chinese Academy of Sciences; University of Chinese Academy of Sciences Department of Thoracic Oncology, Sun Yat-sen University Cancer Center, 510060 Guangzhou, China; Department of Urology, State Key Laboratory of Kidney Diseases, Chinese People’s Liberation Army General Hospital, PLA Medical School, Beijing 100853, China College of Food Science and Engineering, Northwest A&F University, Yangling 712100, Shaanxi, China. Department of Gastroenterology, The Third People's Hospital of Bengbu, Bengbu, 233000, PR China Beijing Tongren Hospital, Capital Medical University, Beijing, China State Key Laboratory of Marine Environmental Science, College of Ocean and Earth Sciences, Xiamen University , Xiamen, 361102 , PR China College of Chemistry and Pharmaceutical Engineering, Nanyang Normal University, Nanyang 473061, China Department of Endodontics, College of Stomatology Tianjin Medical University Tianjin China Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education Co‐innovation Center of Neuroregeneration NMPA Key Lab for Research and Evaluation of Tissue Engineering Technology Products Nantong University Nantong 226000 China School of Materials Science and Engineering Nankai University Tianjin 300350 P. R. China School of Materials Science and Engineering and Institute of Smart Biomedical Materials, Zhejiang Sci-Tech University, Hangzhou 310018, China School of Medical Science and Laboratory Medicine, Jiangsu University, Zhenjiang, Jiangsu, China. Instruments Department, The Second Hospital of Forestry of Heilongjiang Province, Yichun, Heilongjiang, 153100, China. zhangxuresearch@163.com Department of Neurology, Chongqing Key Laboratory of Neurology School of Health Service Management, Anhui Medical University Key Laboratory of Functional Inorganic Material Chemistry, Ministry of Education of the People’s Republic of China, School of Chemistry and Materials Science, Heilongjiang University, Harbin 150080, China Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China; Key Laboratory of Tropical Disease Control of Ministry of Education, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China; Guangdong Engineering Research Center for Antimicrobial Agent and Immunotechnology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, 100190, China Microbiology Institute of Shaanxi Shaanxi Academy of Sciences, Xi'an, China; The Department of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan, China; Hunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Central South University, Changsha, Hunan, China School of Environmental Science and Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China Hunan Institute of Animal Husbandry and Veterinary Medicine, Changsha, China grid.13402.34 000000041759700X Key Laboratory of Biomass Chemical Engineering of Ministry of Education, Department of Chemical and Biological Engineering Zhejiang University 310027 Hangzhou China Department of Surgery, Atlanta Medical Center, Atlanta, Georgia Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangzhou, P. R. China; Department of Nuclear Medicine, Sun Yat-sen University Cancer Center, Guangzhou, P. R. China Biological Science Division and Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, Washington 99352, and Department of Chemistry and Center for Electro- and Photo-Responsive Molecules, Korea University, Seoul 136-701, Korea Harbin Normal University, Harbin, Heilongjiang, China Department of Endodontics, School and Hospital of Stomatology, Tianjin Medical University, Tianjin 300070, P. R. China Harvard John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138; a Key Laboratory of Laboratory Medicine of Jiangsu Province, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu, People’s Republic of China State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University , Shanghai, People’s Republic of China Department of Urology, Chinese PLA General Hospital, Kidney Disease State Key Laboratory of Chinese PLA General Hospital, Beijing, 100853, China *Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China;; †Key Laboratory of Tropical Disease Control of Ministry of Education, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China;; ‡Guangdong Engineering Research Center for Antimicrobial Agent and Immunotechnology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China; School of Pharmacy, Yancheng Teachers University, Yancheng, Jiangsu 224002, P.R. China From the Comprehensive Sickle Cell Center, Section of Hematology/Oncology (X.Z., S.S., V.R.G.), Section of Cardiology (A.A.D.), and Section of Pulmonary, Critical Care, and Sleep Medicine (J.G.N.G., R.F.M.), Department of Medicine, Institute of Human Genetics (W.Z., R.K.), Department of Pediatrics (W.Z.), and Institute for Personalized Respiratory Medicine (A.A.D., T.A., N.G.C., J.G.N.G., R.F.M.), University of Illinois at Chicago, Chicago, IL; Section of Pulmonary/Critical Care, Department of... State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China Department of Oral and Maxillofacial, Head and Neck Oncology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011 China; Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, National Clinical Research Center of Stomatology, Shanghai 200011, China Department of Urology, Chinese PLA General Hospital/Chinese PLA Medical School, Beijing, 100853, P. R. China; State Key Laboratory of Kidney Diseases, Chinese PLA General Hospital/Chinese PLA Medical School, Beijing, 100853, P. R. China Key Laboratory of Subtropical Agriculture and Environment, Ministry of Agriculture Huazhong Agricultural University Wuhan 430070 People's Republic of China; Institute of Environmental Health and Related Product Safety Chinese Center for Disease Control and Prevention Beijing 100021 People's Republic of China State Key Laboratory of Crop Stress Biology for Arid Areas, Key Laboratory of Plant Protection Resources and Pest Management of Ministry of Education, College of Plant Protection, Northwest A&F University, Yangling, Xianyang, 712100 Shaanxi, China School of Pharmacy, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, China Shanghai Key Laboratory of Chemical Assessment and Sustainability; School of Chemical Science and Engineering; Tongji Universtiy; Shanghai 200092; P. R. China Department of BioSciences Rice University Houston TX 77005 USA Department of Chemistry, University of Waterloo, Ontario, N2L 3G1, Canada State Key Laboratory of Chemical Resource Engineering, Beijing, 100029, China, and Department of Polymer Science, Post Office Box 37, and College of Life Science and Technology, Beijing University of Chemical Technology, Beijing, 100029, China Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, China; Institute of Endocrinology and Metabolism, Shandong Academy of Clinical Medicine, Jinan, Shandong, China; Shandong Clinical Medical Center of Endocrinology and Metabolism, Jinan, Shandong, China State Key Laboratory for Physical Chemistry of Solid Surfaces and Department of Chemistry, Xiamen University, Xiamen, 361005, China.; Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100080, China.; State Key Laboratory of Magnetic Resonance and Molecular Physics, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan, 430071, China. Department of Oncology First Affiliated Hospital of Anhui Medical University Hefei China Key Laboratory of Applied Surface and Colloid Chemistry National Ministry of Education, Institute for Advanced Energy Materials, School of Materials Science and Engineering Shaanxi Normal University Xi'an 710119 P. R. China College of Materials Science and Engineering; Xi'an University of Architecture and Technology; Xi'an 710055; P. R. China; School of Chemistry and Chemical Engineering Department of Medicine, Section of Hematology‐Oncology University of Illinois at Chicago Chicago IL Institute of Chinese Sturgeon, China Three Gorges Corporation, Yichang, China and; Hubei Key Laboratory of Three Gorges Project for Conservation of Fishes, Institute of Chinese Sturgeon, China Three Gorges Corporation, Yichang, China Department of Chemistry, Waterloo Institute for Nanotechnology, University of Waterloo, Waterloo, Ontario N2L 3G1, Canada College of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian, China California Institute of Technology 3 Jet Propulsion Laboratory, , 4800 Oak Grove Drive, Pasadena, California 91109-8099, USA Nursing Department Peking Union Medical College Hospital Beijing Dongcheng China Department of Otolaryngology Yongchuan Hospital (T.C.M) of Chongqing Medical University Chongqing China Department of First Clinical Medicine, Shaanxi University of Chinese Medicine, Xian Yang, China Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, PR China;; The Key Laboratory of Major Autoimmune Diseases, Anhui Medical University, Hefei, PR China; Eye Research Institute, Oakland University, Rochester, MI 48309, USA. Department of Thoracic Surgery, The Second Hospital of Dalian Medical University Cardiovascular Hospital Dalian 116000, Liaoning, China. Basic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention, Ministry of Education, Institute of Life Sciences, Chongqing Medical University , Chongqing 400016 , China Departments of Chemistry and Waterloo Institute for Nanotechnology and ‡Department of Biology, University Of Waterloo, Waterloo, Ontario N2L 3G1, Canada School of Mechanical Engineering, Jiangsu University, Zhenjiang 212013, Jiangsu, P. R. China Center of Biostatistics and Bioinformatics University of Mississippi Medical Center Jackson Mississippi Department of Genetic Toxicology, The Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, China School of Engineering and Applied Sciences; Harvard University; Cambridge; USA Department of Urology, State Key Laboratory of Kidney Diseases, Chinese PLA General Hospital, Beijing, China. Department of Gastroenterology, General Hospital of Ningxia Medical University, Yinchuan, China Shanghai Key Laboratory of Chemical Assessment and Sustainability; School of Chemical Science and Engineering; Tongji University; Shanghai 200092; P. R. China Department of Thoracic Surgery, Sun Yat Sen University Cancer Center, Guangzhou, People’s Republic of China; State Key Laboratory of Oncology in Southern China and Collaborative Innovation Center for Cancer Medicine, Guangzhou, People’s Republic of China; Lung Cancer Institute, Sun Yat Sen University, Guangzhou, People’s Republic of China College of Health Science Guangdong Pharmaceutical University Guangzhou Guangdong P. R. China; Guangdong Provincial Key Laboratory of Pharmaceutical Bioactive Substances Guangdong Pharmaceutical University Guangzhou P. R. China Transfusion Medicine Institute Liaoning Blood Center Shenyang Liaoning China; Liaoning Provincial Key Laboratory for Blood Safety Research Shenyang Liaoning China; Key Laboratory of Blood Safety Research of Shenyang Shenyang Liaoning China Department of Chemistry, University of WisconsinMadison, 1101 University Avenue, Madison, Wisconsin 53706 First Hospital of China Medical University Shenyang China Department of Emergency Surgery Affiliated Hospital of Jining Medical University Jining China Department of Stomatology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, P.R. China Department of Pathology, School of Basic Medicine, Lanzhou University, Lanzhou, Gansu 730000, P.R. China Division of Biochemistry, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden. Center of Biostatistics and Bioinformatics, University of Mississippi Medical Center, Jackson, Mississippi, USA Department of Urology, Chinese PLA General Hospital, Beijing - China Key Laboratory of Carbon Materials of Zhejiang Province, College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325035, China Transfusion Medicine Institute Liaoning Blood Center Shenyang China; Liaoning Provincial Key Laboratory for Blood Safety Research Shenyang China; Key Laboratory of Blood Safety Research of Shenyang Shenyang China Medical Isotopes Research Center and Department of Radiation Medicine; School of Basic Medical Sciences; Peking University; Beijing; China Aerospace Information Research Institute, Chinese Academy of Sciences, Beijing 100094, China; School of Physical Science and Technology, Inner Mongolia University, Hohhot 010021, China Institute of Chemistry, the Chinese Academy of Sciences (CAS), and Beijing National Laboratory for Molecular Sciences, Beijing 100190, People’s Republic of China State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Innovation Center for Textile Science and Technology, Donghua University, Shanghai 201620, P. R. China Institute of Chemistry, Chinese Academy of Sciences, and Beijing National Laboratory for Molecular Sciences, Beijing 100190, China; Graduate University of the Chinese Academy of Sciences, Beijing 100064, China College of Chemistry and Materials Science; Jinan University; 510632 Guangzhou; China Yunnan State Key Laboratory of Conservation and Utilization of Biological Resources, College of Plant Protection, Yunnan Agricultural University, Kunming 650201, China Department of Hepato-Biliary-Pancreatic Surgery, Henan Provincial People’s Hospital (People’s Hospital of Zhengzhou University), Zhengzhou, Henan 450000, China Endoscopy Center, Dongping Hospital Affiliated to Shandong First Medical University Taian, Shandong, China. Department of Cardiology, Yijishan Hospital of Wannan Medical College, Wuhu, China.; Key Laboratory of Non-coding RNA Transformation Research of Anhui Higher Education Institution, Wannan Medical College, 241002, Wuhu, China. Key Laboratory of Medical Science and Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu 212013, P.R. China Key Laboratory of Magnetic Resonance in Biological Systems State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics National Center for Magnetic Resonance in Wuhan Wuhan Institute of Physics and Mathematics Innovation Academy for Precision Measurement Science and Technology Chinese Academy of Sciences – Wuhan National Laboratory for Optoelectronics Huazhong University of Science and Technology Wuhan 430071 China; Optics Valley Laboratory Wuhan Hubei 430073 China; University of Chinese Academy of Sciences Beijing 100049 China Department of Ophthalmology The First Affiliated Hospital of Nanjing Medical University Nanjing China College of Life Sciences, Yantai University, Yantai, Shandong 264005, China Center for Clinical and Translational Sciences, University of Texas Health Science Center at Houston, Houston, Texas. Beijing Institute of Technology; Ministry of Education of China Department of Gastroenterology The First Affiliated Hospital of Xi’an Jiaotong University Xi’an P.R. China Institute of Human Virology, China; Key Laboratory of Tropical Disease Control of Ministry of Education, China; Guangdong Engineering Research Center for Antimicrobial Agent and Immunotechnology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, 510080, China Renal Division, Department of Medicine, Peking University First Hospital; Institute of Nephrology, Peking University; Renal Pathology Center, Institute of Nephrology, Peking University First Hospital; Key Laboratory of Renal Disease, Ministry of Health of China; Key Laboratory of CKD Prevention and Treatment, Ministry of Education of China, Beijing, PR China; Department of Electron Microscopy, Pathological Centre, Peking University First Hospital, Beijing, PR China Spectral MD, Inc., 2515 McKinney Avenue, Suite 1000, Dallas, Texas 75201, United States Department of Urology/State Key Laboratory of Kidney Diseases, Chinese PLA General Hospital/PLA Medical School, Beijing, P.R. China Department of Urology, Medical College of People's Liberation Army, Chinese People's Liberation Army General Hospital, Beijing, China. Key Laboratory of Applied Surface and Colloid Chemistry, Ministry of Education, Shaanxi Key Laboratory for Advanced Energy Devices, Shaanxi Engineering Lab for Advanced Energy Technology, School of Materials Science and Engineering, Shaanxi Normal University, Xi’an 710119, China; Dalian National Laboratory for Clean Energy, iChEM, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China School of Chemistry, Chemical Engineering and Life Science and State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Wuhan 430070, China School of Basic Medical Sciences Anhui Medical University Hefei 230032 Anhui China From the Department of Anatomy and the State Key Laboratory of Brain and Cognitive Science, Hong Kong, China; the Provincial Key Laboratory of Agrobiology Institute of Food Crops Jiangsu Academy of Agricultural Sciences Nanjing China Robert and Arlene Kogod Center on Aging Mayo Clinic Rochester MN USA Key Laboratory for Biomedical Engineering of Ministry of Education, College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou, China; Tianjin Key Laboratory of Metabolic Diseases; Key Laboratory of Immune Microenvironment and Disease (Ministry of Education); Collaborative Innovation Center of Tianjin for Medical Epigenetics and Department of Physiology and Pathophysiology, Tianjin Medical University, Tianjin, China School of Life Sciences Hubei Key Laboratory of Genetic Regulation and Integrative Biology, Central China Normal University Wuhan China Department of Urology/State Key Laboratory of Kidney Diseases, Chinese PLA General Hospital/PLA Medical School, Beijing 100853, P.R. China Department of Head and Neck, Henan Tumor Hospital, Zhengzhou University, 127 Dongming Road, Zhengzhou, Henan 450008, China Key Laboratory of Arid and Grassland Ecology of Ministry of Education, School of Life Science, Lanzhou University, Lanzhou 73000, China. zhang_x06@lzu.cn Tianjin Key Laboratory of Metabolic Diseases, Collaborative Innovation Center of Tianjin for Medical Epigenetics, Center for Cardiovascular Diseases, Research Center of Basic Medical Sciences, Department of Physiology and Pathophysiology, Tianjin Medical University, China (Y.Z., X.Z.). Beijing Epigenetics Biotechnology Co., Ltd Beijing China University of Pittsburgh School of Medicine, Departments of Medicine and Computational Biology, Pittsburgh, Pennsylvania 15261 Department of Radiation Oncology Shengjing Hospital of China Medical University, Shenyang Shenyang China Key Laboratory of Human Disease Comparative Medicine, Ministry of Health, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences, Beijing, China Center for Membrane and Water Science & Technology, Institute of Oceanic and Environmental Chemical Engineering, State Key Lab Breeding Base of Green Chemical Synthesis Technology, Zhejiang University of Technology, Hangzhou 310014, P. R. China Institute of Physics; University of Chinese Academy of Sciences Department of Anesthesiology, Xuzhou Central Hospital, Jiangsu 221009, China School of Medicine and Life Sciences, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210023, P.R. China Department of Electrical and Computer Engineering, Carnegie Mellon University; Pittsburgh, Pennsylvania 15213, United States Clinical College, National Biochip Research Center Sub-center in Ningxia, General Hospital of Ningxia Medical University, Yinchuan 750004, China. Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Zhejiang, China From the Department of Ophthalmology, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan; and the Center of Biostatistics & Bioinformatics University of Mississippi Medical Center Jackson, Mississippi Department of Medicine, University of Illinois , 808 S. Wood St., Chicago, IL 60612, USA Department of Dermatology, Huaian First Hospital Affiliated to Nanjing Medical University, Jiangsu. hapfkyszhx@sina.com School of Chemistry and Chemical Engineering Institute for Innovative Materials and Energy Yangzhou University, Yangzhou 225009 Jiangsu P. R. China Authors' Affiliations: 1Department of Urology, Military Postgraduate Medical College, Chinese People's Liberation Army General Hospital, Beijing, China; 2Department of Urology, The University of Kansas Medical Center, Kansas City, Kansas; 3Department of Pharmacology, Three Gorges University College of Medicine, Yichang, China; 4Strand Biotechnology Institute of Research, Shantou, China; 5Department of Pharmacology & Toxicology, The University of Kansas Medical Center, Kansas City, Kansas School of Engineering and Applied Science, Harvard University, Cambridge, Massachusetts 02138, United States Department of Pathology, Luzhou Medical College, Luzhou, People's Republic of China. College of Chemistry and Pharmaceutical Engineering; Nanyang Normal University; Nanyang 473061; P. R. China Department of Endocrinology and Metabolism Shandong Provincial Hospital Affiliated to Shandong University Jinan China; Institute of Endocrinology and Metabolism Shandong Academy of Clinical Medicine Jinan China Department of Cardiovascular Surgery General Hospital of Northern Theater Command Shenyang China College of Artificial Intelligence, National University of Defense Technology , Changsha, Hunan 410073, China and , Changsha, Hunan 410073, China; Interdisciplinary Center for Quantum Information, National University of Defense Technology , Changsha, Hunan 410073, China and , Changsha, Hunan 410073, China Alberta Centre for Toxicology, University of Calgary, Calgary, Alberta, Canada Department of Neurosurgery the Affiliated Hospital of Xuzhou Medical University Xuzhou China Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States Department of Nutrition and Health, Beijing Advanced Innovation Center for Food Nutrition and Human Health, No. 10 Tianxiu Road, Haidian District, China Agricultural University , Beijing 100193 , China State Key Laboratory of Grassland Agro-Ecosystem, Institute of Innovation Ecology and College of Life Sciences, Lanzhou University, Lanzhou, China College of Life Science; Hunan Normal University; Hunan Provincial Key Laboratory of Microbial Molecular Biology-State Key Laboratory Breeding Base of Microbial Molecular Biology; Changsha China Jiangsu Key Laboratory of Medical Science and Laboratory Medicine; School of Medicine; Jiangsu University; Zhenjiang, Jiangsu, PR China Key Laboratory of Human Disease Comparative Medicine, Ministry of Health, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences, Beijing, China. Department of Traditional Chinese Medicine, Huadong Hospital, Fudan University, Shanghai 200040, P.R. China Department of Medical Oncology, State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center , Guangzhou, Guangdong , China School of Flexible Electronics (Future Technologies) & Institute of Advanced Materials Jiangsu National Synergetic Innovation Center for Advanced Materials School of Physical and Mathematical Sciences Nanjing Tech University Nanjing 211816 China Beijing Engineering Research Center for Experimental Animal Models of Human Diseases Institute of Laboratory Animal Science Peking Union Medical College Chinese Academy of Medical Sciences Beijing China National & Local Joint Engineering Research Center of Targeted and Innovative Therapeutics, Chongqing Engineering Laboratory of Targeted and Innovative Therapeutics, Chongqing Key Laboratory of Kinase Modulators as Innovative Medicine, Chongqing Collaborative Innovation Center of Targeted and Innovative Therapeutics, College of Pharmacy & IATTI, Chongqing University of Arts and Sciences, Chongqing 402160, China School of Materials Science and Engineering, Computational Centre for Molecular Science, Institute of New Energy Material Chemistry, Nankai University, Tianjin 300350, P. R. China Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials; Ministry-of-Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules; College of Chemistry & Chemical Engineering; Hubei University; Wuhan State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 China Department of Microbiology and Immunology, Weill Cornell Medicine, Cornell University, Ithaca, NY 14853 College of Laboratory Medicine Dalian Medical University Dalian Liaoning Province China School of Life Sciences, Northeast Normal University, Changchun, China National Engineering Laboratory for Internet Medical Systems and Applications The First Affiliated Hospital of Zhengzhou University Zhengzhou Henan China Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China; College of Life and Environmental Science Wenzhou University Wenzhou China School of Biotechnology and Health Sciences, Wuyi University, Jiangmen 529020, China School of Gemology and Materials, Hebei GEO University, Shijiazhuang 050031, China; Engineering Research Center for Silicate Solid Waste Resource Utilization of Hebei Province, Shijiazhuang 050031, China; Hebei Key Laboratory of Green Development of Rock Mineral Materials, Shijiazhuang 050031, China Contribution from the Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, Singapore 117543, State Key Laboratory of Magnetic Resonance and Molecular and Atomic Physics, Wuhan Institute of Physics and Mathematics, The Chinese Academy of Sciences, Wuhan, 430071, PR China, and Department of Chemistry, National University of Singapore, 14 Science Drive 4, Singapore 117543 Clinical Center for Recurrent Spontaneous Abortion & Recurrent Implantation Failure Shenzhen Zhongshan Urological Hospital Shenzhen China; Fertility Center Shenzhen Zhongshan Urological Hospital Shenzhen China; Shenzhen Zhongshan Institute for Reproductive Medicine and Genetics Shenzhen China §Institute of Neuroscience, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China; Drug Synthesis Engineering Technology Research Center of Henan Province for Photoelectric Green Catalysis Engineering Technology Research Center of Henan Province for Solar Catalysis College of Chemistry and Pharmaceutical Engineering Nanyang Normal University Henan 473061 China The Criminal Investigation Department of Beijing Public Security Bureau, Key Laboratory of Forensic Toxicology, Ministry of Public Security, 1st Longgang Road, Haidian District, Beijing 100085, China Chinese PLA General Hospital, Beijing, China From the Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, MOE Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, P.R. China (Q.L., S.X., X. Chen, X. Zhang, X.L., L.L., D.G., M.W., S.Y., X. Cao, T.T., W.H., J.G., L. Huang, R.C., X. Zhou, W.C., T.X., Q.G., Y.W., M.H., X.W., G.Z., Y.Z., C.Z., X.Y., L. Hao, Nianhong Yang) Department of Chemistry and Waterloo Institute for Nanotechnology and ‡Department of Biology, University of Waterloo, 200 University Avenue West, Waterloo, Ontario, Canada N2L 3G1 Shanghai Key Laboratory of Chemical Assessment and Sustainability School of Chemical Science and Engineering Tongji University 1239 Siping Rd. Shanghai 200092 China Jiangsu Key Laboratory of Medical Science and Laboratory Medicine, The Affiliated Hospital, School of Medicine, Jiangsu University, 301 Xuefu Road, Zhenjiang, Jiangsu 212013, P.R. China , Phone: +86 511 85038215; Fax: +86 511 85038449 Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, China (mainland) Department of Physics and Astronomy, California State University—Northridge, Northridge, California 91330, United States Department of Medicine, University of Illinois, Chicago, Illinois, 60607, USA Key Laboratory of Beam Technology of Ministry of Education, College of Nuclear Science and Technology, Beijing Normal University, Beijing 100875, China Department of Urology, the Third Medical Centre, Chinese PLA General Hospital, 28 Fuxing Road, Beijing, 100853, China Departments of Histology and NeurobiologyKarolinska InstituteStockholmSweden School of Chemistry and Chemical Engineering; Henan Key Laboratory of Biomolecular Recognition and Sensing; Henan D&A Engineering Center of Advanced Battery Materials; Shangqiu Normal University; Shangqiu 476000 Division of Hematology and Oncology Department of Medicine Comprehensive Sickle Cell Center University of Illinois at Chicago Chicago IL USA School of Automation Engineering, University of Electronic Science and Technology of China 1 , Chengdu 611731, China Tianjin Key Laboratory of Metabolic Diseases Key Laboratory of Immune Microenvironment and Disease‐Ministry of Education Department of Physiology and Pathophysiology Collaborative Innovation Center of Tianjin for Medical Epigenetics Tianjin Medical University Tianjin China Center for Multidimensional Carbon Materials (CMCM) Institute for Basic Science (IBS) Ulsan 44919 Republic of Korea College of Life and Environmental Science; Wenzhou University; Wenzhou 325035; P.R. China; WZU&WMU Collaborative Innovation Center of Biomedicine Department of Stem Cell Biology, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki 852-8523, Japan Department of Chemistry & Biochemistry, University of Colorado, Boulder, Colorado 80309-0215, Jet Propulsion Laboratory, California Institute of Technology, 4800 Oak Grove Drive, Pasadena, California 91109-8099, Institute for Physical Chemistry, University of Basel, Klingelbergstrasse 19, CH-4056 Basel, Switzerland, Department of Chemistry, Colorado College, Colorado Springs, Colorado 80903-3298, Physical Chemistry Laboratory, Oxford University, South Parks Road, Oxford, OX1 3QZ, United Kingdom,... College of Civil Engineering, Henan University of Technology, Zhengzhou 450001, China California Institute of Technology Jet Propulsion Laboratory, , Pasadena, California 91109-8099 School of Dentistry Hospital of Stomatology Tianjin Medical University Tianjin China Data Science Institute, Shandong University 2 , Jinan 250100, People’s Republic of China The State Key Laboratory of Protein and Plant Gene Research College of Life Sciences School of Agriculture Science Peking University Beijing 100871 China; Department of Molecular Biology and Institute of Genetics and Genomics University of Geneva 30 Quai Ernest‐Ansermet 1211 Geneva Switzerland Tianjin Key Laboratory of Metabolic Diseases, Department of Physiology and Pathophysiology Tianjin Medical University Tianjin China CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, No. 11, First North Road, Zhongguancun, Beijing, China 100190 Liaoning Blood Center Transfusion Medicine Institute Shenyang China; Liaoning Provincial Key Laboratory for Blood Safety Research Shenyang China Institute of Pesticide; School of Horticulture and Plant Protection and School of Chemistry and Chemical Engineering; Yangzhou University; Yangzhou; P. R. China Al-ion Battery Research Center, Department of Electrical Engineering and Automation, Shandong University of Science and Technology, Qingdao, Shandong 266590, China School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou, Jiangsu 225002, China Beijing University of Chinese Medicine, China-Japan Friendship Hospital State Key Laboratory of Crop Stress Biology for Arid Areas, Key Laboratory of Plant Protection Resources and Pest Management of Ministry of Education, College of Plant Protection Northwest University Xianyang China School of Life Sciences Tianjin University Tianjin 300072 China Key Laboratory of Subtropical Agriculture and Environment, Ministry of Agriculture, Huazhong Agricultural University, Wuhan 430070, China Key Laboratory of Analytical Science and Technology of Hebei Province, College of Chemistry and Materials Science, Hebei University, Baoding 071002, P. R. China The Key Laboratory of Rare Metabolic Disease,Nanjing Medical University,Nanjing,China; Department of Biochemistry and Molecular Biology,Nanjing Medical University,Nanjing,China; The Key Laboratory of Human Functional Genomics of Jiangsu Province,Nanjing Medical University,Nanjing,China Neuroradiology Section, Department of Diagnostic and Interventional Radiology, University of Texas at Houston Shanghai University; Huazhong University of Science and Technology College of Agronomy and Horticulture, Jiangsu Vocational College of Agriculture and Forestry, Zhenjiang 212400, China; Jiangsu Engineering and Technology Center for Modern Horticulture, Zhenjiang 212400, China Department of Vascular Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing 100730, China. Dalian Medical University, Dalian, China College of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, Zhejiang 311402, P.R. China *Rosalind and Morris Goodman Cancer Research Center, McGill University, Montreal, Quebec H3A 1A3, Canada;; †Department of Biochemistry, McGill University, Montreal, Quebec H3A 1A3, Canada; State Key Laboratory of Grassland Agro‐Ecosystem Institute of Innovation Ecology & College of Life Sciences Lanzhou University Lanzhou 730000 China School of Chemistry and Chemical Engineering Huaiyin Normal University Huaian 223300 China Key Laboratory of Tropical Disease Control of Ministry Education Guangdong Engineering Research Center for Antimicrobial Agent and Immunotechnology Institute of Human Virology Sun Yat‐sen University Guangzhou Guangdong P. R. China Department of Parasitology, Medical School, Xi'an Jiaotong University, Xi'an 710061. State Key Laboratory of Material-Oriented Chemical Engineering; College of Chemical Engineering; Nanjing Tech University; Nanjing 210009; China School of Materials Science and Engineering, Ningxia Research Center of Silicon Target and Silicon-Carbon Negative Materials Engineering Technology, North Minzu University, Yinchuan 750021, China Department of Otolaryngology Head and Neck Surgery and Department of allergy, Beijing TongRen Hospital, Capital Medical University, Beijing, China.; Beijing Key Laboratory of Nasal Diseases, Beijing Institute of Otolaryngology, Beijing, China. State Key Laboratory of Fine Chemicals, School of Petroleum & Chemical Engineering, Dalian University of Technology, Panjin 124221, China College of Light Industry and Food Sciences, South China University of Technology, 381 Wushan Road, 510641, Guangzhou, PR China Liaoning Blood Center, Shenyang, Liaoning 110044, China. ljp_63@163.com. College of Resources and Environmental Engineering, Wuhan University of Science and Technology, Hubei, People’s Republic of China Department of Urology Surgery, People's Liberation Army General Hospital Beijing 100853, China. Center for Multidimensional Carbon Materials (CMCM), Institute for Basic Science (IBS), Ulsan 44919, Republic of Korea School and Hospital of Stomatology, Tianjin Medical University, 300070 Tianjin, China Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States Department of Chemistry and Institute of Biomedical Sciences, Fudan University, Shanghai, 200433, China, State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Institute, of Physics and Mathematics, Chinese Academy of Sciences, Wuhan 430071 China, and Department of Biochemistry, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong Department of Urology, The Third Medical Center, Chinese PLA General Hospital/Medical School of Chinese PLA/State Key Laboratory of Kidney Diseases, Chinese PLA General Hospital, Beijing 100853, P.R. China Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China; School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 100102, China. Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences Beijing 100700, China College of Pharmacy, Hebei Medical University Shijiazhuang 050017, China. The Department of Dermatology, Xiangya Hospital Central South University Changsha Hunan China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital Changsha Hunan China; Hunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital Changsha Hunan China; Hunan Engineering Research Center of Skin Health and Disease, Xiangya Hospital Central South University Changsha Hunan China; Xiangya Clinical Research Center for Cancer ImmunoTherapy Central South University Changsha Hunan China Laboratory of Advanced Materials, Fudan University, Shanghai 200433, China National Key Laboratory of Crop Genetics and Germplasm Enhancement and Utilization Sanya Institute of Nanjing Agricultural University, College of Horticulture, Nanjing Agricultural University Nanjing Jiangsu 210095 China Department of Chemistry Fudan University 220 Handan Road 200433 Shanghai China Department of Urology, the third Medical Center, Chinese PLA General Hospital, Beijing, China School of Automation, Jiangsu University of Science and Technology, Zhenjiang 212013, China Division of Biochemistry, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden. Beijing Urban Construction Design & Development Group Co., Ltd., Beijing 100037, China. Department of Building Science, Tsinghua University, Beijing 100084, China; Beijing Key Laboratory of Indoor Air Quality Evaluation and Control, Beijing 100084, China State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Med-X Center for Materials, West China Hospital of Stomatology, Sichuan University, China Transfusion Medicine Institute Liaoning Blood Center Shenyang Liaoning China; Liaoning Provincial Key Laboratory for Blood Safety Research Shenyang Liaoning China Zhejiang Key Laboratory of Carbon Materials, College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou, Zhejiang 325035, China; School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou, Jiangsu 225002, China Affiliated Eye Hospital of Nanchang University, Jiangxi Research Institute of Ophthalmology and Visual Science, Jiangxi Provincial Key Laboratory for Ophthalmology, Nanchang, Jiangxi 330006, P.R. China College of Clinical Medicine, Chengdu University of TCM, Chengdu, P.R. China Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials Ministry-of-Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules College of Chemistry & Chemical Engineering Hubei University Wuhan 430062 P. R. China East China University of Science and Technology Shanghai Key Laboratory of Advanced Polymeric Materials and Key Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science and Engineering, , Shanghai 200237, China Division of Nephrology, Taixing People's Hospital, Taixing, China; and Department of Biomedical Sciences, City University of Hong Kong, Kowloon Tong, Hong Kong; Key Laboratory of Laboratory Medicine of Jiangsu Province, The Affiliated Hospital, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu, P. R. China Department of Urology Chinese People's Liberation Army General Hospital Beijing China Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Jiangsu Key Laboratory of Zoonosis, School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou, Jiangsu 225002, China Engineering Technology Research Center of Henan Province for Solar, Catalysis College of Chemistry and Pharmaceutical Engineering Nanyang Normal University Nanyang 473061 P. R. China Jiangsu Breast Disease Center, The First Affiliated Hospital with Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, China Department of Chemistry and Biochemistry, University of Colorado, Boulder, Colorado 80309-0215 Department of Pharmacy, Zhujiang Hospital, Southern Medical University, Guangdong, Guangzhou, People's Republic of China; School of Pharmacy Henan University of Chinese Medicine Zhengzhou China Hebei Province Key Laboratory of Occupational Health and Safety for Coal Industry, School of Public Health, North China University of Science and Technology, Tangshan, Hebei, P.R. China Department of First Clinical Medicine Shaanxi University of Chinese Medicine Xian Yang China Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany Key Laboratory of Human Disease Comparative Medicine Institute of Laboratory Animal Science Chinese Academy of Medical Sciences Beijing China Institute of Human Virology; Key Laboratory of Tropical Disease Control of Ministry of Education; Guangdong Engineering Research Center for Antimicrobial Agent and Immunotechnology, Zhongshan School of Medicine, SunYat-Sen University School of Engineering London South Bank University London UK Faculty of Materials and Manufacturing Key Laboratory of Advanced Functional Materials Education Ministry of China Beijing University of Technology Beijing 100124 P. R. China Department of Pharmacology The 88th Hospital of PLA Tai'an China; Department of Pharmacology Taishan Medical University Tai'an China Department of Chemistry, Shanghai University, Shanghai 200444, China Key Laboratory of Advanced Optoelectronic Quantum Architecture and Measurement, Ministry of Education, School of Physics, Beijing Institute of Technology, Beijing, 100081, China Department of Physical Education, Northwest University, No. 229 Taibai North Road, Xi’an, Shaanxi 710069, China Northwest University, School of Information Sciences and Technology, Xi’an, China Department of Urology The First Medical Center of Chinese PLA General Hospital Beijing China Jiangxi Provincial Key Laboratory for Ophthalmology, Jiangxi Research Institute of Ophthalmology and Visual Science, Affiliated Eye Hospital of Nanchang University, Nanchang, Jiangxi, 330006, P.R. China The Third Medical Center of PLA General Hospital, Beijing, China; College of Nuclear Science and Technology, Beijing Normal University, Beijing 100875, China; Advanced Institute of Natural Sciences, Beijing Normal University at Zhuhai, Zhuhai 519087, China Transfusion Medicine Institute Liaoning Blood Center Shenyang China; Liaoning Provincial Key Laboratory for Blood Safety Research Shenyang China Key Laboratory of Magnetic Resonance in Biological Systems, State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National Center for Magnetic Resonance, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan 430071, China;, Department of Dermatology Xiangya Hospital Central South University Changsha China; National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology Changsha China; Furong Laboratory Changsha China; Hunan Key Laboratory of Skin Cancer and Psoriasis Hunan Engineering Research Center of Skin Health and Disease Xiangya Hospital Central South University Changsha China; National Clinical Research Center for Geriatric Disorders (Xiangya Hospital) Changsha China Key Laboratory of Human Disease Comparative Medicine NHFPC Institute of Laboratory Animal Science Chinese Academy of Medical Sciences & Comparative Medical Center Peking Union Medical College Beijing China Department of Electronic Materials Engineering, Research School of Physics and Engineering, The Australian National University, Canberra, ACT 2601, Australia; School of Information Engineering, Zhengzhou University, Zhengzhou 450052, China School of Nursing Jilin University Changchun Jilin China Department of Urology, Third Medical Center, Chinese PLA General Hospital, Beijing, P.R. China. Department of Stem Cell Biology, Nagasaki University Graduate School of Biomedical Sciences Ottawa Institute of Systems Biology and Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada, K1H 8M5 National Glycoengineering Research Center, School of Pharmaceutical Science, Shandong University, Jinan 250012, China Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling, School and Hospital of Stomatology, Jilin University, 1500 Qinghua Road, Changchun 130021, People’s Repbulic of China Department of Chemistry and Key Laboratory of Organic Synthesis of Jiangsu Province, Soochow University, Suzhou 215123, People’s Republic of China CAS Key Laboratory of SSAC Department of Biotechnology Dalian Institute of Chemical Physics Chinese Academy of Sciences Dalian China Shandong Provincial Key Laboratory of Molecular Engineering, School of Chemistry and Chemical Engineering, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250353, China Key Laboratory of Molecule Synthesis and Function Discovery, Fujian Province University College of Chemistry at Fuzhou University Fuzhou, Fujian 350108 China Mechanical College, Shanghai Dianji University, Shanghai, China Key Laboratory of Powder Material & Advanced Ceramics International Scientific & Technological Cooperation Base of Industrial Waste Recycling and Advanced Materials Ningxia Research Center of Silicon Target and Silicon‐Carbon Negative Materials Engineering Technology School of Materials Science & Engineering North Minzu University Yinchuan 750021 P. R. China School of Medicine Hangzhou City University Hangzhou China; College of Life Sciences Zhejiang Normal University Jinhua China Departments of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of China HLA Laboratory Liaoning Blood Center Shenyang Liaoning China; Key Laboratory of Blood Safety Research of Liaoning Shenyang Liaoning China Dalian Institute of Chemical Physics 1 , Chinese Academy of Sciences, 457, Zhongshan Road, Dalian, 116023, China; Graduate School of the Chinese Academy of Sciences 2 , Beijing, China Department of Urology, State Key Laboratory of Kidney Diseases, Chinese PLA General Hospital, PLA Medical School, Beijing, China. *Department of Vascular Surgery, Peking Union Medical College Hospital, Beijing 100730, People’s Republic of China; School of Stomatology Hospital of Stomatology Tianjin Medical University Tianjin 300070 China State Key Laboratory of Bioactive Substance and Function of Natural Medicines; Institute of Materia Medica; Chinese Academy of Medical Sciences; Peking Union Medical College; Beijing 100050 Department of Thoracic Surgery, National Cancer Center, National Clinical Research Center for Cancer, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China Department of Information Science and Engineering, Chongqing Jiaotong University, Chongqing 400074, China Collaborative Innovation Center of Tianjin for Medical Epigenetics and Department of Physiology and Pathophysiology,Tianjin Medical University,Tianjin,China School of Environmental Science and Engineering, Tianjin University, Tianjin 300354, China Department of Immunology and Pathogenic Biology; Medical College of Xi'an Jiaotong University; Xi'an People's Republic of China Institute of Oceanic and Environmental Chemical Engineering; State Key Lab Breeding Base of Green Chemical Synthesis Technology; Zhejiang University of Technology; 310014 Hangzhou; P. R. China Beijing Key Laboratory of Fundamental Research on Biomechanics in Clinical Application, School of Biomedical Engineering, Capital Medical University, No. 10 Xitoutiao, You An Men Wai, Beijing 100069, China Department of Neurology and Institute for Stroke and Cerebrovascular Disease UTHealth Houston Texas Department of Neurosurgery, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China Division of Hematology & Oncology Department of Medicine Comprehensive Sickle Cell Center University of Illinois at Chicago Chicago IL USA General Surgery Division of Hematology and Oncology, Department of Medicine University of Illinois at Chicago Chicago Illinois USA Key Laboratory of Optic‐electric Sensing and Analytical Chemistry for Life Science Ministry of Education Shandong Key Laboratory of Biochemical Analysis College of Chemistry and Molecular Engineering Qingdao University of Science and Technology Qingdao 266042 China Beijing Key Lab of Microstructure and Properties of Solids Faculty of Materials and Manufacturing Beijing University of Technology Beijing 100124 China Department of Hematology, Qilu Hospital, Shandong University, Jinan, Shandong, China Department of Biomedical Engineering, Duke University, Durham, NC, USA. Institute for Cancer Genetics, Columbia University, New York, NY 10032, USA; Department of Pediatrics, Columbia University, New York, NY 10032, USA; Department of Genetics and Development, Columbia University, New York, NY 10032, USA for the THALES Steering Committee and Investigators College of Food Science and Engineering; Ocean University of China; Qingdao; China State Key Laboratory of Marine Resource Utilization in South China Sea, College of Oceanology, Hainan University, Haikou 570228, China Guangdong Provincial Maternity and Child Health Care Hospital, Guangzhou 511400, Guangdong, PR China High Educational Key Laboratory of Natural Medicinal Pharmacology and Druggability of Guizhou Province School of Pharmacy Guizhou Medical University Guiyang 550025 Guizhou P. R. China Department of Physics and Astronomy; California State University; Northridge; Northridge; USA Department of Biomedical Engineering; Duke University; Durham; USA The State Key Laboratory of Protein and Plant Gene Research, College of Life Sciences, School of Agriculture Science, Peking University, 100871 Beijing, P. R. China;; Department of Molecular Biology, Institute of Genetics and Genomics, University of Geneva, 1211 Geneva, Switzerland; Department of Electronic Materials Engineering, Research School of Physics and Engineering, The Australian National University, Canberra, ACT 2601, Australia; National Center for International Joint Research of Electronic Materials and Systems, Henan Key Laboratory of Laser and Opto-electric Information Technology, School of Information Engineering, Zhengzhou University, Zhengzhou, Henan 450052, P. R. China School of Chemistry and Chemical Engineering, Liaoning Normal University, Dalian 116029, People’s Republic of China Department of Ophthalmology, the Fourth Affiliated Hospital of China Medical University, Eye Hospital of China Medical University, Provincial Key Laboratory of Lens Research, Shenyang 110005, Liaoning Province, China. Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China. State Key Laboratory of Crop Gene Exploration and Utilization in Southwest China Sichuan Agricultural University Chengdu 611130 China Department of Urology/State Key Laboratory of Kidney Diseases, Chinese People's Liberation Army General Hospital/PLA Medical School, Beijing, People's Republic of China Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, China; Shandong Clinical Medical Center of Endocrinology and Metabolism, Jinan, Shandong 250021, China; Institute of Endocrinology and Metabolism, Shandong Academy of Clinical Medicine, Jinan, Shandong 250021, China Department of Head Neck and Thyroid Surgery, Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou 470000, P.R. China. Key Lab for Special Functional Materials of Ministry of Education National & Local Joint Engineering Research Center for High‐efficiency Display and Lighting Technology School of Materials Science and Engineering, and Collaborative Innovation Center of Nano Functional Materials and Applications Henan University Kaifeng 475004 P. R. China Verschuren Centre for Sustainability in Energy and the Environment, Cape Breton University, 1250 Grand Lake Road, Sydney, Nova Scotia B1P 6L2, Canada Department of Neurology The First Affiliated Hospital of Wenzhou Medical University Zhejiang China School of Mechanical Engineering & Automation, Dalian Polytechnic University, Dalian 116034, China Institut des Sciences Chimiques de Rennes (ISCR)-UMR CNRS 6226 Université de Rennes 1 35042 Rennes Cedex France; Institut National des Sciences Appliquées (INSA) Université Européenne de Bretagne 35043 Rennes Cedex France College of Chemistry and Environmental Engineering, Yangtze University, Jingzhou 434020, Hubei, P. R. China Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University Health Science Center; Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China (L.Y., R.D., H.W., Z.C., N.X., X.Z., Y.S., Z.G., Y.J., F.Y., Y.F., Z.L., W.K.).; NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Beijing, China (L.Y., R.D., H.W., Z.C., N.X., X.Z., Y.S., Z.G., Y.J., F.Y., Y.F., Z.L., W.K.). a College of Urban Construction, Nanjing Tech University, Puzhu Road 30, Nanjing 211816, China School of Biomedical Engineering, Capital Medical University , Beijing 100069 , China; Beijing Advanced Innovation Center for Big Data-Based Precision Medicine, Capital Medical University , Beijing 100069 , China; Beijing Key Laboratory of Fundamental Research on Biomechanics in Clinical Application, Capital Medical University , Beijing 100069 , China Institute of Neuroscience, Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, China Department of Polymer Science and Engineering, Hebei University of Technology, Tianjin 300130, P.R. China Institute of Human Virology, Key Laboratory of Tropical Disease Control of Ministry of Education, Guangdong Engineering Research Center for Antimicrobial Agent and Immunotechnology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, Guangdong, China College of Wildlife And Protected Area, Northeast Forestry University, Harbin, China State Key Laboratory of Crop Genetics and Germplasm Enhancement, College of Agronomy Nanjing Agricultural University/JCIC‐MCP Nanjing 210095 Jiangsu China Department of Ecology and Evolution, University of Chicago, Chicago, Illinois 60637 Department of Urology, Chinese People's Liberation Army General Hospital 28 Fuxing Road, Haidian District, Beijing 100853, China. Laboratory of Sensory System, Institute of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, China; Chinese National Human Genome Center at Shanghai, 351 Guo Shou-Jing Road, Shanghai 201203, China; and Institute of Neuroscience, Fourth Military Medical University, 17 Chang Le Xi Road, Xian 710032, China Department of Urology/State Key Laboratory of Kidney Diseases, The First Medical Center, Chinese PLA General Hospital, Beijing, China Department of Gynecology, Shanghai Municipal Hospital of Traditional Chinese Medicine Shanghai University of Traditional Chinese Medicine Shanghai China; Department of Traditional Chinese Medicine Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine Shanghai China CAS Key Laboratory of Plant Germplasm Enhancement and Specialty Agriculture, Chinese Academy of Sciences, Wuhan Botanical Garden, Wuhan 430074, Hubei, People's Republic of China; Center of Conservation Biology, Chinese Academy of Sciences, Core Botanical Gardens, Wuhan 430074, People's Republic of China; University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing 210028, China; Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210028, China Jiangsu Key Laboratory of Medical Science and Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu 212013, P.R. China The First Hospital of Tsinghua University Beijing China Institute of Human Virology Key Laboratory of Tropical Disease Control of Ministry Education Guangdong Engineering Research Center for Antimicrobial Agent and Immunotechnology Zhongshan School of Medicine Sun Yat‐sen University Guangzhou Guangdong 510080 China Department of Medicine, Division of Hematology and Oncology, University of Illinois at Chicago, Chicago, Illinois Institute of Brain-Intelligence Technology, Zhangjiang Laboratory; Shanghai Research Center for Brain Science & Brain-Inspired Intelligence, Shanghai 201210, China; Institute of Neuroscience and State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science, Chinese Academy of Sciences, Shanghai 200031, China; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China Institute of Physics Chinese Academy of Sciences Beijing 100084 P. R. China Division of Hematology and Oncology, Department of Medicine, University of Illinois at Chicago, Chicago, IL; Department of Urology, Chinese PLA General Hospital, Beijing, China Department of Neurology, The Affiliated Hospital of Qingdao University, China Department of Traditional Chinese Medicine, Huadong Hospital Affiliated to Fudan University, Shanghai 200040, China; Shanghai Key Laboratory of Clinical Geriatric Medicine, Huadong Hospital Affiliated to Fudan University, Shanghai 200040, China Gastroenterology Department Ningxia Medical University General Hospital Yinchuan Ningxia China Beijing National Laboratory for Condensed Matter Physics, Key Laboratory of Medical Science and Laboratory Medicine of Jiangsu Province School of Medicine Jiangsu University 301 Xuefu Road 212013 Zhenjiang Jiangsu People's Republic of China Department of Electrical Engineering and Computer Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States Provincial Key Laboratory of Agrobiology, Institute of Biotechnology, Jiangsu Academy of Agricultural Sciences, Nanjing 210014, China Liaoning Blood Center, Shenyang, Liaoning 110044, China; Shenyang Research Center for Stem Cell Clinical Application, Shenyang, Liaoning 110044, China. Email: ljp_63@163.com. Department of Neurology, the First Affiliated Hospital of Wenzhou Medical College, Wenzhou, China College of Nuclear Science and Technology, Harbin Engineering University, Harbin 150001, China; Laboratory of Nuclear Energy Chemistry, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China Department of Dermatology, Hunan Engineering Research Center of Skin Health and Disease, Hunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Clinical Research Center for Cancer Immunotherapy, Xiangya Hospital, Central South University, Changsha, Hunan, China; National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology, Central South University, Changsha, Hunan, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian 350002, China Department of Chemistry, University of Pittsburgh, Pittsburgh Pennsylvania 15260, and Laboratory of Comparative Carcinogenesis, Chemistry Section, National Cancer Institute at Frederick, Frederick, Maryland 21702 State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National Center for Magnetic Resonance in Wuhan, Wuhan Institute of Physics and Mathematics, the Chinese Academy of Sciences, Wuhan, 430071, PR China School of Life Sciences, Tianjin University, Tianjin 300072, China Center for Life Science; School of Life Sciences; Yunnan University; Kunming 650021; China Guangdong Key Lab for Biomedical Measurements and Ultrasound Imaging, Shenzhen, 518060. Shenzhen Key Lab for Biomedical Engineering, Shenzhen, 518060. State Key Laboratory of Magnetic Resonance and Atomic Molecular Physics National Center for Magnetic Resonance in Wuhan Innovation Academy for Precision Measurement Science and Technology Chinese Academy of Sciences 430071 Wuhan China; University of Chinese Academy of Sciences 100049 Beijing China CAS Key Laboratory of Plant Germplasm Enhancement and Specialty Agriculture Wuhan Botanical Garden Chinese Academy of Sciences Wuhan China Department of Neuroscience, Karolinska Institutet, 171 77, Stockholm, Sweden; and Department of Neurobiology, Institute of Neuroscience, 4th Military Medical University, Xian, People’s Republic of China State Key Laboratory of Oral Diseases, National Clinical Research Centre for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, China.; Shandong Clinical Medical Center of Endocrinology and Metabolism, Jinan, Shandong, China.; Institute of Endocrinology and Metabolism, Shandong Academy of Clinical Medicine, Jinan, Shandong, China. Center for Emerging and Zoonotic Diseases, College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, PR China Centre de Recherche en Cancérologie de Marseille (CRCM) CNRS, Aix-Marseille Université, Inserm Institut Paoli-Calmettes 27 bd Lei Roure 13273 Marseille CEDEX 9 France Department of Environmental Science and Engineering, Tsinghua University , Beijing , China Department of Urology the Third Medical Center Chinese PLA General Hospital No.39 Yongding Road Beijing 100039 China Capital Medical University; Beijing Advanced Innovation Center for Big Data-Based Precision Medicine College of Chemistry and Molecular Sciences Institute for Advanced Studies Wuhan University Wuhan Hubei 430072 P. R. China Department of Oncology, the First Affiliated Hospital of Anhui Medical University , Hefei, China; Menzies Institute for Medical Research, University of Tasmania , Tasmania, Australia and; Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University , Hefei, China Institute of Large-Scale Scientific Facility and Centre for Zero Magnetic Field Science, Beihang University, Beijing 100191, China; National Institute of Extremely-Weak Magnetic Field Infrastructure, Hangzhou 310051, China Department of Automation; Tsinghua National Laboratory for Information Science and Technology (TNLIST); Tsinghua University; Beijing; China Department of Anatomy; College of Basic Medical Sciences, China Medical University; Shenyang; China Guangdong Key laboratory for innovative Development and Utilization of Forest Plant Germplasm; College of Forestry and Landscape Architecture; South China Agricultural University; Guangzhou; People's Republic of China National University of Defense Technology, College of Intelligence Science and Technology 1 , Changsha, Hunan 410073, China; National University of Defense Technology, Interdisciplinary Center for Quantum Information 2 , Changsha, Hunan 410073, China State Key Laboratory of Bioactive Substance and Function of Natural Medicines; Institute of Materia Medica; Peking Union Medical College; Chinese Academy of Medical Sciences; Beijing 100050 Laboratory for Reproductive Health Institute of Biomedicine and Biotechnology Shenzhen Institute of Advanced Technology Chinese Academy of Sciences Shenzhen China Department of Oncology and Hematology, The Third Affiliated Hospital of Shenyang Medical College, Shenyang 110034, China Changchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Sciences, Changchun 130033, China; University of Chinese Academy of Sciences, Beijing 101408, China Dr. X. Zhang Department of Biomedical Engineering Duke University Durham NC 27708 USA College of Intelligence Science and Technology, National University of Defense Technology 1 , Changsha, Hunan 410073, China; Interdisciplinary Center for Quantum Information, National University of Defense Technology 2 , Changsha, Hunan 410073, China Department of Breast Surgery The First Affiliated Hospital of Nanjing Medical University 300 Guangzhou Road Nanjing 210029 China Key Laboratory of Functional Polymer Materials, Institute of Polymer Chemistry, Nankai University, Tianjin, 300071, China, and Département de chimie, Université de Montréal, C.P. 6128, succursale Centre-ville, Montreal, Québec H3C 3J7, Canada Beijing Engineering Research Center for Experimental Animal Models of Human Diseases, Institute of Laboratory Animal Science, Peking Union Medicine College Chinese Academy of Medical Sciences Beijing China Beijing International Scientific and Technological Cooperation Base of Water Pollution Control Techniques for Antibiotics and Resistance Genes, School of Civil Engineering, Beijing Jiaotong University, 3 Shangyuancun, Beijing 100044, P. R. China Key Laboratory of Molecule Synthesis and Function Discovery Fujian Province University College of Chemistry at Fuzhou University Fuzhou Fujian 350108 China Key Laboratory of Medical Science and Laboratory Medicine of Jiangsu Province, School of Medicine, Jiangsu University, Zhenjiang 212013, Jiangsu, P.R. China Independent Scholar/Translator, Shanghai, China Department of Physics and Astronomy; California State University Northridge; Northridge; USA Institute of Chemistry, Chinese Academy of Sciences, and Beijing National Laboratory for Molecular Sciences, Beijing 100190, China; Graduate University of Chinese Academy of Sciences, Beijing 100064, China Guangzhou Editgene Co., Ltd., Guangzhou 510630, China State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National Center for Magnetic Resonance in Wuhan, Wuhan National Laboratory for Optoelectronics, Wuhan Institute of Physics and Mathematics, Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences, Wuhan 430071, China; University of Chinese Academy of Sciences, Beijing 100049, China; Optics Valley Laboratory, Wuhan 430074, China Department of Biology, University of Waterloo, Waterloo, Ontario, N2L 3G1, Canada Clinical Research Center, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, China;; School of Public Health, Xi’an Jiaotong University Health Science Center, Xi’an, China; CAS Key Laboratory of SSAC; Dalian Institute of Chemical Physics; Chinese Academy of Sciences; Dalian; P.R. China Institute of Neuroscience and State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China; School of Life Science and Technology, ShanghaiTech University, Shanghai, China Division of BiochemistryDepartment of Medical Biochemistry and BiophysicsKarolinska InstitutetStockholmSweden Department of Ecology and Evolution Department of Diagnostic Radiology, Division of Neuroradiology, University of Texas Health Science Center at Houston, Houston, TX, USA Institut des Sciences Chimiques de Rennes (ISCR)–CNRS UMR 6226 Université de Rennes 1 35042 Rennes Cedex France; Institut National des Sciences Appliquées (INSA) 35043 Rennes Cedex France Department of Gastroenterology, Yudu County People’s Hospital, Ganzhou, Jiangxi, P.R.China The State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology Shanghai China Ottawa Institute of Systems Biology, Department of Biochemistry, Microbiology and Immunology, University of Ottawa, 451 Smyth Road, Ottawa, Ontario Canada, K1H8M5 College of Intelligence Science and Technology, National University of Defense Technology, Changsha 410073, China; Interdisciplinary Center for Quantum Information, National University of Defense Technology, Changsha 410073, China State Key Laboratory of Fine Chemicals, Department of Materials Science and Chemical Engineering, Dalian University of Technology, Dalian 116012, P. R. China Department of Urology, State Key Laboratory of Kidney Diseases, Chinese People's Liberation Army General Hospital, PLA Medical School, Beijing 100853, P.R. China Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, Ontario, Canada; School of Pharmaceutical Sciences, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada; SIMM-University of Ottawa Joint Research Center in Systems and Personalized Pharmacology, University of Ottawa, Ottawa, Ontario, Canada Key Laboratory of Physics and Technology for Advanced Batteries (Ministry of Education), College of Physics, Jilin University, Changchun 130012, China Guangdong Key Laboratory for Innovative Development and Utilization of Forest Plant Germplasm, College of Forestry and Landscape Architecture, South China Agricultural University, Guangzhou 510642, China Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, United States; Department of Applied Physics, Harvard University, Cambridge, Massachusetts 02138, United States University of Texas Health Science Center at Houston, TX, USA Jiangsu Collaborative Innovation Center of Traditional, Chinese Medicine Prevention and Treatment of Tumor, Nanjing 210023, P. R. China Key Laboratory for Magnetism and Magnetic Materials of Ministry of Education & School of Physical Science and Technology; Lanzhou University; P. R. China Key Laboratory of Flexible Electronics and Institute of Advanced Materials, School of Physical and Mathematical Sciences, Nanjing Tech University, Nanjing 211816, China State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine; Cancer Center; Sun Yat-sen University; Guangzhou 510060 Department of Chemistry, Waterloo Institute for Nanotechnology, University of Waterloo, Waterloo, Ontario, Canada N2L 3G1 Beijing Engineering Research Center for Experimental Animal Models of Human Diseases, Institute of Laboratory Animal Science, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100021, P.R. China State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Institute of Physics and Mathematics, The Chinese Academy of Sciences, 430071 Wuhan, China Department of Gastroenterology, General Hospital of Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region 750004, P.R. China CAS Key Laboratory of SSAC; Department of Biotechnology; Dalian Institute of Chemical Physics; Chinese Academy of Sciences; China State Key Laboratory of Nonferrous Metals and Processes, China GRINM Group Co., Ltd., Beijing 100088, China; GRIMAT Engineering Institute Co., Ltd., Beijing 101407, China; General Research Institute for Nonferrous Metals, Beijing 100088, China CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety and CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology , Beijing , China; University of Chinese Academy of Sciences , Beijing , China Shandong Provincial Key Laboratory of Animal Cell and Developmental Biology, School of Life Sciences, Advanced Medical Research Institute Shandong University Qingdao Shandong China Beijing National Biochip Research Center Sub-center in Ningxia, General Hospital of Ningxia Medical University, College of Clinical Medicine, Ningxia Medical University, Yinchuan 750004, China. School of Civil Engineering, Beijing Jiaotong University, Beijing 100044, China Tianjin Medical University School and Hospital of Stomatology, Tianjin, China (mainland) Department of Physics and Astronomy, California State University, Northridge, CA 91330, USA. Department of Urology, State Key Laboratory of Kidney Diseases Chinese PLA General Hospital, PLA Medical School Beijing China Department of Cardiology, Yijishan Hospital of Wannan Medical College, Wuhu, China Department of Hepato-Biliary-Pancreatic Surgery, People’s Hospital of Zhengzhou University (Henan Provincial People’s Hospital), 450000 Zhengzhou, China Tianjin Key Laboratory of Metabolic Diseases, Key Laboratory of Immune Microenvironment and Disease-Ministry of Education, Department of Physiology and Pathophysiology, Collaborative Innovation Center of Tianjin for Medical Epigenetics, Tianjin Medical University , Tianjin, China State Key Laboratory of Magnetic Resonance and Atomic Molecular Physics, National Center for Magnetic Resonance in Wuhan, Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences, Hubei 430071, China; University of Chinese Academy of Sciences, Beijing 100049, China PLA General Hospital, China School of Life Science and Engineering, Foshan University, Foshan 528000, China National Research Center for Wildlife-Borne Diseases, Institute of Zoology, Chinese Academy of Sciences, No. 1-5 Beichenxi Road, Chaoyang District, Beijing, People's Republic of China 100101; Sichuan Forensic Expertise Center in Southwest China Chengdu Sichuan Province China School of Biomedical Engineering, Capital Medical University, Beijing, China; Beijing Key Laboratory of Fundamental Research on Biomechanics in Clinical Application, Capital Medical University, Beijing, China Department of Chemistry & Key Laboratory of Organic Synthesis of Jiangsu Province, Soochow University, Suzhou 215123, P. R. China Department of Endocrinology Provincial Hospital Affiliated to Shandong University Jinan China; Institute of Endocrinology Shandong Academy of Clinical Medicine Jinan China Department of Urology, General Hospital of PLA, Beijing, China (mainland) Department of Traditional Chinese Medicine, Huadong Hospital Affiliated to Fudan University, Shanghai, China Department of Radiology, University of Mississippi Medical Center, 2500 N State St, Jackson, MS 39216. Department of Respiratory, West China Hospital, Sichuan University, Chengdu 610041, China. Institute of Modern Optics Tianjin Key Laboratory of Micro-scale Optical Information Science and Technology Nankai University Tianjin 300350 P. R. China Central Laboratory, Xuan Wu Hospital, Capital Medical University, Beijing Geriatric Medical Research Center, Key Laboratory for Neurodegenerative Disease of Ministry of Education, Beijing, China State Key Laboratory of Magnetic Resonance and Atomic Molecular Physics National Center for Magnetic Resonance in Wuhan Innovation Academy for Precision Measurement Science and Technology Chinese Academy of Sciences University of Chinese Academy of Sciences Hubei 430071 P. R. China; University of Chinese Academy of Sciences Beijing 100049 P. R. China Department of Nephrology Liaoning Translational Medicine Center of Nephrology, the First Affiliated Hospital of Dalian Medical University Dalian China School of Life Sciences, Tsinghua University, Beijing 100084, China. Alberta Centre for Toxicology, University of Calgary , Calgary, AB T2N 4N1 , Canada Jiangsu Key Laboratory of Medical Science and Laboratory Medicine, Institute of Stem Cell, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu 212013, China School of Medical Science and Laboratory Medicine, Jiangsu University, Zhenjiang, People's Republic of China. Department of Internal Medicine (X.Z.), McGovern Medical School, UTHealth, Houston, TX Department of Hand Surgery, The Third Affiliated Hospital of Hebei Medical University, Shijiazhuang City, Hebei Province, P.R. China School of Biotechnology and Health Sciences; Wuyi University; Jiangmen; China Center for Clinical and Translational Sciences, The University of Texas Health Science Center at Houston, Houston, Texas Institute of Oceanic and Environmental Chemical Engineering, State Key Laboratory Breeding Base of Green Chemical Synthesis Technology, Zhejiang University of Technology, Hangzhou 310014, China College of Life Sciences and Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China.; School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen 518055, China. Department of Chemistry, University of Nebraska−Lincoln, Lincoln, Nebraska 68588, United States Theoretical and Applied Mechanics Program Northwestern University 2145 Sheridan Rd. Evanston IL 60208 USA Department of Biostatistics, Epidemiology, and Research Design Component of the Center for Clinical and Translational Sciences McGovern Medical School and University of Texas Health Science Center, Houston, Texas, USA Department of Neurosurgery Renmin Hospital of Wuhan University Wuhan China Institute of Biomechanics and Medical Engineering, School of Aerospace Engineering, Tsinghua University, Beijing 10084, People's Republic of China Section of Hematology/Oncology , Department of Medicine, The University of Illinois, Chicago, Illinois 60612 3Department of Urology, The First Medical Center of Chinese PLA General Hospital, Beijing, China. Department of Oral and Maxillofacial‐Head and Neck Oncology, Shanghai Ninth People's Hospital, College of Stomatology Shanghai Jiao Tong University School of Medicine; National Clinical Research Center for Oral Disease; Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology Shanghai China Liaoning Blood Center, Shenyang 110044, Liaoning Province,China. E-mail:sandra_zx@163.com. Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; Ministry of Education Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National Center for Magnetic Resonance in Wuhan, Wuhan Institute of Physics and Mathematics, Innovation Academy for Precision Measurement of Science and Technology Chinese Academy of Sciences Wuhan China; University of Chinese Academy of Sciences Beijing China; Wuhan National Laboratory for Optoelectronics Huazhong University of Science and Technology Wuhan China; Optics Valley Laboratory Wuhan China College of Intelligence Science and Technology; Interdisciplinary Center for Quantum Information College of Animal Science and Technology; Key Laboratory of Animal Genetics and Breeding of Ministry of Agriculture; National Engineering Laboratory of Animal Breeding; China Agricultural University; Beijing 100193 China Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, 199 Ren-Ai Road, Suzhou, Jiangsu 215123, China Department of Anaesthesiology, Xuzhou Central Hospital, Xuzhou, China Department of Urology, Tongji Hospital/Medical College, Huazhong University of Science and Technology, Wuhan, China. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Peking Union Medical College and Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing 100050, China Developmental and Regenerative Biology, School of Biomedical Sciences, The Chinese University of Hong Kong, Shatin, Hong Kong Department of Clinical Psychology, the Affiliated Hospital of Qingdao University, Qingdao, Shandong, P.R. China Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China School of Chemistry and Chemical Engineering, Yangzhou University School and Hospital of Stomatology Tianjin Medical University 12 Observatory Road Tianjin 30070 China Key Laboratory of Human Disease Comparative Medicine NHFPC Institute of Laboratory Animal Science Peking Union Medicine College Chinese Academy of Medical Sciences Beijing China Key Laboratory for Analytical Science of Food Safety and Biology of MOE, Fujian Provincial Key Lab of Analysis and Detection for Food Safety, College of Chemistry, Fuzhou University, Fuzhou, Fujian 350116, China Department of Nephrology, Liaoning Translational Medicine Center of Nephrology The First Affiliated Hospital of Dalian Medical University Dalian China Nationwide Children’s Hospital, Columbus, OH, USA State Key Laboratory of Kidney Disease Department of Urology Chinese PLA Medical Academy Chinese People's Liberation Army General Hospital Beijing China College of Life Science, Huaibei Normal University, Huaibei, PR China Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China (mainland) Institute of Human Virology, Key Laboratory of Tropical Disease Control of Ministry of Education, Guangdong Engineering Research Center for Antimicrobial Agent and Immunotechnology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China Bioinspired Engineering and Biomechanics Center (BEBC), The Key Laboratory of Biomedical Information Engineering of Ministry of Education, Xi'an Jiaotong University 1 , Xi'an 710049, People's Republic of China Division of Hematology and Oncology, Department of Medicine Comprehensive Sickle Cell Center, University of Illinois at Chicago Chicago Illinois Key Laboratory of Magnetic and Resonance in Biological Systems State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics Centre for Magnetic Resonance Wuhan Institute of Physics and Mathematics Chinese Academy of Sciences Wuhan China Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, People’s Republic of China Department of Medical Biochemistry and Biophysics, Division of Biochemistry, Karolinska Institutet, SE-17177 Stockholm, Sweden Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, China; The Key Laboratory of Major Autoimmune Diseases, Anhui Medical University, Hefei, Anhui, China Department of Orthopedics, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai 201399, P.R. China Department of Orthopedics Shanghai Pudong Hospital Fudan University Pudong Medical Center Shanghai China State Key Laboratory of Kidney Diseases, Department of Urology Chinese PLA General Hospital/PLA Medical School, Beijing, China. Department of Endocrinology and Metabolism, Shandong Provincial Hospital affiliated to Shandong University, Jinan, China.; Institute of Endocrinology, Shandong Academy of Clinical Medicine, Jinan, China. School of Nursing Jilin University Jilin China Alfred Wegener Institute for Polar and Marine Research, D-27570 Bremerhaven, Germany; State Key Laboratory of Oncology in South China Collaborative Innovation Center of Cancer Medicine Guangzhou China; Department of Thoracic Oncology Sun Yat‐sen University Cancer Center Guangzhou China; Guangdong Esophageal Cancer Institute Guangzhou China Authors' Affiliations: 1State Key Laboratory of Kidney Diseases, Department of Urology, Military Postgraduate Medical College, Chinese People's Liberation Army General Hospital, Beijing; and 2Department of Urology, Zhongnan Hospital, Wuhan University, Wuhan, People's Republic of China School of Chemistry and Chemical Engineering, Huaiyin Normal University, Jiangsu Engineering Laboratory for Environment Functional Materials, Jiangsu Collaborative Innovation Center of Regional Modern Agriculture & Environmental Protection, No. 111, West Changjiang Road, Huaian, Jiangsu 223300, China Department of Neurosurgery The second Affiliated Hospital of XinJiang Medical University Wulumuqi City China School of Mathematics and Statistics, Southwest University, China State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 P. R. China School of Petroleum & Chemical Engineering, Dalian University of Technology, Panjin Campus, Panjin 124221, Liaoning China Department of Endocrinology , The First Hospital of Qinhuangdao , Qinhuangdao , Hebei Province , P.R. China Thoracic and Gastrointestinal Oncology Branch Center for Cancer Research, National Cancer Institute Bethesda MD USA Institute for Tissue Engineering and Regenerative Medicine The Chinese University of Hong Kong New Territories Hong Kong SAR; School of Biomedical Sciences Faculty of Medicine The Chinese University of Hong Kong New Territories Hong Kong SAR The First Hospital of China Medical University, Shenyang, Liaoning, China Biologic and Radiopharmaceutical Drugs Directorate, Health Canada, Ottawa, ON, Canada Department of Gastroenterology and Hepatology of Tianjin Third Central Hospital, Tianjin Institute of Hepatobiliary Disease, Tianjin Key Laboratory of Artificial Cell, Artificial Cell Engineering Technology Research Center of Public Health Ministry, Tianjin, China; Key Laboratory of Human Functional Genomics of Jiangsu Province, Nanjing Medical University, Nanjing, China Harvard John A. Paulson School of Engineering and Applied Sciences Harvard University Cambridge MA 02138 USA; Cape Breton University 1250 Grand Lake Road Sydney NS B1P 6L2 Canada Department of Stomatology Shanghai Tenth People's Hospital Tongji University School of Medicine Shanghai China Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260 Institute of Food Crops, Jiangsu Academy of Agricultural Sciences/Jiangsu Collaborative Innovation Center for Modern Crop Production, Nanjing 210014, China Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY, USA. Department of Urology, State Key Laboratory of Kidney Disease, Chinese PLA Medical Academy, Chinese People’s Liberation Army General Hospital, Beijing, China China Information and Communication Technologies Group Corporation (CICT) Liaoning Blood Center, Shenyang, Liaoning 110044, China; Shenyang Research Center for Cell Application, Shenyang, Liaoning 110044, China. Email: ljp_63@163.com. Department of Biochemistry, School of Basic Medical Sciences, Wenzhou Medical University , Wenzhou Transfusion Medicine Institute, Liaoning Blood Center Shenyang China; Liaoning Provincial Key Laboratory for Blood Safety Research Shenyang China; Key Laboratory for Blood Safety Research of Shenyang Shenyang China School of Materials Science and Engineering; Hefei University of Technology; Hefei 230009; China Medical Isotopes Research Center and Department of Radiation Medicine; School of Basic Medical Sciences; Peking University Health Science Center; Beijing; China Centre for Quantum Physics, Key Laboratory of Advanced Optoelectronic Quantum Architecture and Measurement (MOE), School of Physics, Beijing Institute of Technology, Beijing 100081, China; Yangtze Delta Region Academy of Beijing Institute of Technology, Jiaxing 314019, China; Beijing Key Lab of Nanophotonics and Ultrafine Optoelectronic Systems, School of Physics, Beijing Institute of Technology, Beijing 100081, China School of Food Science, Northeast Agricultural University Department of Molecular Medicine and Neurodegeneration New Medicines Center The Scripps Research Institute La Jolla CA USA Key Laboratory of Functional Inorganic Material Chemistry Ministry of Education of the People's Republic of China Heilongjiang University Harbin 150080 China School of Information Sciences and Technology, Northwest University, Xi’an, Shaanxi 710069, China School of Mechanical, Electrical & Information Engineering, Shandong University, Weihai, China Section of Hematology/Oncology , Department of Medicine, University of Illinois, Chicago, Illinois 60612 School and Hospital of Stomatology Tianjin Medical University Tianjin 300070 People's Republic of China Department of Statistical Science, Fox School of Business, Temple University, Philadelphia, Pennsylvania Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, MOE Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science & Technology , Wuhan, 430030 , China School of Nursing Jilin University Changchun Jilin People's Republic of China Department of Electrical and Computer Engineering, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, United States Muscle Dynamics Group Max Planck Institute of Biochemistry Martinsried Germany College of Life Science, Northeast Agricultural University, Xiangfang District, Harbin, China Sun Yat-sen University Cancer Center; State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China; Department of Nuclear Medicine, Sun Yat-sen University Cancer Center, Guangzhou 510060, China Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong 510080, China; Key Laboratory of Tropical Disease Control of Ministry of Education, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong 510080, China; and Guangdong Engineering Research Center for Antimicrobial Agent and Immunotechnology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong 510080, China Department of Nutrition, School of Public Health, Sun Yat-sen University (Northern Campus), Guangzhou 510080, China. National Engineering Research Center for Ophthalmology, Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing, China; Beijing National Laboratory for Condensed Matter Physics and Institute of Physics Chinese Academy of Sciences Beijing 100190 PR China Psychological Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China Daqing Branch of Heilongjiang Academy of Sciences; Daqing 163319; P. R. China Mechanical Engineering and Materials Science, Duke University, Box 90300 Hudson Hall, Durham, NC, US Department of Chemistry and Biochemistry, University of Colorado, Boulder, Colorado 80309-0215, National Renewable Energy Laboratory, 1617 Cole Blvd., Golden, Colorado 80401, and Institute for Theoretical Chemistry, Department of Chemistry, University of Texas, Austin, Texas 78712 Department of Orthopedics, The First People’s Hospital of Chuzhou, Anhui, China. 1Thoracic and Gastrointestinal Oncology Branch, Center for Cancer Research, NCI, Bethesda, Maryland. Key Laboratory of Functional Polymer Materials, Institute of Polymer Chemistry, Nankai University, Tianjin, 300071, China, and Département de Chimie, Université de Montréal, C.P. 6128, Succ. Centre-ville, Montréal, QC, H3C 3J7, Canada State Key Laboratory of Integrated Optoelectronics, College of Electronic Science and Engineering, Jilin University, Changchun 130015, China Biomedical Engineering Program, University of Science and Technology of China, Hefei, P. R. China Department of Chemistry, Rutgers University, Newark, NJ 07102, USA Molecular Imaging Center, Mallinckrodt Institute of Radiology, Department of Ophthalmology and Visual Sciences, Department of Developmental Biology, Washington University Medical School, St. Louis, Missouri 63110 Department of Epidemiology School of Public Health, Nanjing Medical University Nanjing China Jiangsu Breast Disease Center The First Affiliated Hospital with Nanjing Medical University Nanjing China Departments of Chemistry and Waterloo Institute for Nanotechnology, ‡Department of Biology, University Of Waterloo, Waterloo, Ontario N2L 3G1, Canada Shanghai Key Laboratory of Advanced Polymeric Materials, State Key Laboratory of Bioreactor Engineering, Key Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, China Department of Pharmaceutical Sciences School of Pharmacy Texas Tech University Health Sciences Center Amarillo Texas 79106 School of Chemical Engineering; Northwest University; Xi'an; P. R. China Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN Department of Electrical and Computer Engineering Carnegie Mellon University Pittsburgh PA 15213 USA Division of Biotechnology, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. Beijing Engineering Research Center for Experimental Animal Models of Human Diseases Institute of Laboratory Animal Science Peking Union Medicine College Chinese Academy of Medical Sciences Beijing China Department of Urology, State Key Laboratory of Kidney Diseases, Chinese People's Liberation Army General Hospital, PLA Medical School, Beijing, People's Republic of China. Department of Oncology, China-Japan Friendship Hospital, Yinghuayuan East Street 2, Chaoyang, Beijing, China; Beijing University of Chinese Medicine, No. 11, 3rd Ring Road East, Chaoyang, Beijing, China Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University , Hefei, Anhui, China; The Key Laboratory of Major Autoimmune Diseases , Anhui, China Research Fellow, Department of Anesthesiology and Intensive Care Medicine, Changhai Hospital, Second Military Medical University. School of Chemistry and Chemical Engineering Institute of Pesticide of School of Horticulture and Plant Protection Yangzhou University Yangzhou Jiangsu 225002 P.R. China Department of Radiology Shengjing Hospital of China Medical University Shenyang 110004 China State Key Laboratory of Elemento-Organic Chemistry and Department of Chemical Biology, National Pesticide Engineering Research Center (Tianjin), Nankai University, Tianjin 300071, China School of Life Sciences and CAS Key Laboratory of Innate Immunity and Chronic Disease, University of Science and Technology of China, Hefei, Anhui, China Department of Urology, State Key Laboratory of Kidney Diseases, Chinese PLA General Hospital, Beijing, People’s Republic of China Department of Neurosurgery, Renmin Hospital of Wuhan University, Wuhan 430060, China Center for Clinical and Translational Sciences, McGovern Medical School at the University of Texas Health Science Center at Houston, Houston Department of Oral and Maxillofacial Surgery, School of Stomatology, China Medical University, Liaoning, China State Key Laboratory of Magnetic Resonance and Atomic Molecular Physics, National Center for Magnetic Resonance in Wuhan, Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences, Wuhan 430071, China; University of Chinese Academy of Sciences, Beijing 100049, China State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Zhang Jiang Hi-Tech Park, Pudong, Shanghai 201203, P. R. China; University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing 100049, China Tianjin Key Laboratory of Metal and Molecule Based Material Chemistry Computational Centre for Molecular Science Institute of New Energy Material Chemistry Collaborative Innovation Center of ChemicalScience and Engineering (Tianjin) School of Materials Science and Engineering National Institute for Advanced Materials Nankai University Tianjin 300350 P. R. China Department of Endocrinology, Shandong Provincial Hospital affiliated to Shandong University, Jinan, China.; Shandong Clinical Medical Center of Endocrinology and Metabolism, Jinan, China.; Institute of Endocrinology and Metabolism, Shandong Academy of Clinical Medicine, Jinan, China. Department of Chemistry, University of Wisconsin-Madison, 1101 University Avenue, 53706-1396, Madison, WI, USA Department of Medical Record Management, The Affiliated YanAn Hospital of Kunming Medical University, Yunnan, China Department of Prosthodontics, The First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, Xinjiang Uygur Autonomous Region, People's Republic of China Division of Anti‐tumor Pharmacology, Shanghai Institute of Materia Medica Chinese Academy of Sciences Shanghai China; School of Pharmaceutical Sciences University of Chinese Academy of Sciences Beijing China Department of Chemistry and Waterloo Institute for Nanotechnologyand ‡Department of Biology, University of Waterloo, 200 University Avenue West, Waterloo, Ontario, Canada N2L 3G1 School of Materials Science and Engineering, Wuhan University of Technology, Wuhan, Hubei 430070, China State Key Laboratory of Marine Resource Utilization in the South China Sea, College of Oceanology, Hainan University, Haikou, China University of Illinois at ChicagoChicago, Illinoisand Department of Entomology, College of Plant Protection, Nanjing Agricultural University , Nanjing 210095 Jiangsu, China Key Laboratory of Rubber-plastics Ministry of Education School of Polymer Science and Engineering Qingdao University of Science and Technology Zhengzhou Rd. 53 CN-266042 Qingdao China The Affiliated Eye Hospital, Nanchang University, Nanchang, Jiangxi 330000, P.R. China Jiangsu Key Laboratory of Medical Science and Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu 212013, China; Institute of Digestive Diseases, The Affiliated People's Hospital of Jiangsu University, Zhenjiang, Jiangsu 212002, China School of Economics and Management, Zhejiang Agriculture and Forestry University, Hangzhou 311300, China Jiangsu Key Laboratory of Medical Science and Laboratory Medicine School of Medicine Jiangsu University Zhenjiang 212013 P. R. China Department of Anesthesiology and Intensive Care Medicine, Changhai Hospital, The Second Military Medical University, Shanghai 200433, P.R. China National Engineering Research Center for Harmless Treatment and Resource Utilization of Industrial Wastewater, School of Resources and Environmental Engineering, East China University of Science and Technology, Shanghai 200237, China. State Environmental Protection Key Laboratory of Environmental Risk Assessment and Control on Chemical Process, School of Resources and Environmental Engineering, East China University of Science and Technology, Shanghai 200237, China. Affiliated Eye Hospital of Nanchang University, Jiangxi Research Institute of Ophthalmology and Visual Science, Nanchang, China; Jiangxi Provincial Collaborative Innovation Center for Cardiovascular, Digestive and Neuropsychiatric Diseases, Nanchang, China University of Chinese Academy of Sciences Laboratory of Controllable Nanopharmaceuticals, Chinese Academy of Sciences (CAS), Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, No. 11, First North Road, Zhongguancun, Beijing 100190, China; University of Chinese Academy of Sciences, Beijing 100049, China Affiliated Eye Hospital of Nanchang University, Jiangxi Research Institute of Ophthalmology and Visual Science, Jiangxi Provincial Key Laboratory for Ophthalmology, Jiangxi Clinical Research Center for Ophthalmic Disease, Nanchang, China 1The Key Laboratory of Rare Metabolic Disease, Department of Biochemistry and Molecular Biology, The Key Laboratory of Human Functional Genomics of Jiangsu Province, Key Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, Nanjing, China Beijing University of Chinese Medicine, Beijing, China College of Construction Engineering, Jilin University, Changchun 130021, China; National-Local Joint Engineering Laboratory of In-situ Conversion, Drilling and Exploitation Technology for Oil Shale, Jilin University, Changchun 130021, China; Provincial and Ministerial Co-construction of Collaborative Innovation Center for Shale Oil & Gas Exploration and Development, Changchun 130021, China; Key Lab of Ministry of Natural Resources for Drilling and Exploitation Technology in Complex Conditions, Jilin University, Changchun 130021, China Department of Ultrasonography, Wangjing Hospital, Chinese Academy of Traditional Chinese Medicine, Beijing, China (mainland) 1Division of Hematology & Oncology, Department of Medicine, Department of Chemistry and Waterloo Institute for Nanotechnology, and ‡Department of Biology, University of Waterloo, 200 University Avenue West, Waterloo, Ontario N2L 3G1, Canada Key Laboratory of Optimal Utilization of Natural Medicinal Resources, Guizhou Medical University, Guiyang, PR China; School of Pharmacy, Guiyang Medical University, Guiyang, PR China Guangdong Institute of Intelligence Science and Technology, 519031 Zhuhai, China; Research Unit of Pain Medicine, Chinese Academy of Medical Sciences; SIMR Joint Lab of Drug Innovation, Shanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai, 201210 China; School of Life Science and Technology, ShanghaiTec University, 201210 Shanghai, China Department of Ophthalmology and Visual Sciences, and School of Materials Science and Engineering National Institute for Advanced Materials Institute of New Energy Material Chemistry Collaborative Innovation Center of Chemical Science and Engineering (Tianjin) Nankai University Tianjin 300350 China CIMMYT-JAAS Joint Center for Wheat Diseases, The Research Center of Wheat Scab, Jiangsu Academy of Agricultural Sciences, Nanjing 210014, China Department of Urology, Tongji Hospital, Tongji Medical University, Wuhan, China. Liaoning Blood Center, Shenyang, Liaoning 110044, P.R. China. ljp_63@163.com. Institute of Electronic Engineering; China Academy of Engineering Physics; Mianyang; China Single Cell Center, CAS Key Laboratory of Biofuels and Shandong Key Laboratory of Energy Genetics, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao, Shandong 266101, China Department of Allergy, Beijing Tongren Hospital, Capital Medical University, Beijing, China; Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, China; Beijing Key Laboratory of Nasal Diseases, Beijing Institute of Otolaryngology, Beijing, China; Beijing Laboratory of Allergic Diseases and Beijing Key Laboratory of Nasal Diseases, Beijing Institute of Otolaryngology, Beijing, China Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. a Department of Chemistry , Huaqiao University , Quanzhou, Fujian , 362011 , China Key Laboratory of Magnetic Resonance in Biological Systems, State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National Center for Magnetic Resonance in Wuhan, Wuhan Institute of Physics and Mathematics, Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences-Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan 430071, China; University of Chinese Academy of Sciences, Beijing 10049, China Mechanical Engineering Department of Dalian Polytechnic University , Dalian 116034 , China Center for Studies of Psychological Application Guangdong Key Laboratory of Mental Health and Cognitive Science Research Center for Crisis Intervention and Psychological Service of Guangdong Province, & School of Psychology South China Normal University Guangzhou People's Republic of China Institute of Optics and Electronics, Chinese Academy of Sciences; University of Chinese Academy of Sciences iChEM Dalian National Laboratory for Clean Energy Dalian Institute of Chemical Physics Chinese Academy of Sciences Dalian 116023 China College of Laboratory Medicine Dalian Medical University Liaoning Province China Key Laboratory of Organic Synthesis of Jiangsu Province College of Chemistry Chemical Engineering and Materials Science Soochow University 199 Ren‐Ai Road Suzhou Jiangsu 215123 China Beijing Key Laboratory of Growth and Developmental Regulation for Protected Vegetable Crops, College of Horticulture, China Agricultural University , Beijing, P. R. China CAS Key Laboratory for Biological Effects of Nanomaterials & Nanosafety National Center for Nanoscience and Technology No 11 Beiyitiao, Zhongguancun Beijing 100190 China Department of Electrical and Computer Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, USA. Department of Dermatology Xiangya Hospital, Central South University Changsha Hunan China; Hunan Key Laboratory of Skin Cancer and Psoriasis Changsha Hunan China; Hunan Engineering Research Center of Skin Health and Disease Changsha Hunan China; National Clinical Research Center for Geriatric Disorders Xiangya Hospital Changsha Hunan China Center of Synthetic and Systems Biology, School of Life Science, Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing 100084, China Department of Urology, Chinese People’s Liberation Army (PLA) General Hospital, Beijing, China (mainland) Shanghai Key Laboratory of Atmospheric Particle Pollution and Prevention, Department of Environmental Science and Engineering, Fudan University, Shanghai 200433, China Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China University of Colorado Department of Chemistry and Biochemistry, , Boulder, Colorado 80309-0215 Institute of Advanced Battery Materials and Devices Faculty of Materials and Manufacturing Beijing University of Technology Beijing 100124 P. R. China; Key Laboratory of Advanced Functional Materials Ministry of Education Beijing University of Technology Beijing 100124 P. R. China Guangdong Institute of Intelligence Science and Technology Zhuhai China; Institute of Neuroscience and State Key Laboratory of Neuroscience CAS Center for Excellence in Brain Science and Intelligence Technology Shanghai China; School of Life Science and Technology ShanghaiTech University Shanghai China; Research Unit of Pain, Chinese Academy of Medical Sciences, Shanghai Advanced Research Institute Chinese Academy of Sciences Shanghai China Division of Hematology & Oncology, Department of Medicine University of Illinois at Chicago Chicago Illinois Department of Urology/State Key Laboratory of Kidney Diseases, The First Medical Center, Chinese PLA General Hospital, Beijing, China. School of Mechanical Engineering Tongji University Shanghai China College of Chemistry and Pharmaceutical Engineering, Nanyang Normal University, Nanyang, Henan 473061, China Center of Biostatistics and Bioinformatics, Department of Preventive Medicine, University of Mississippi Medical Center, Jackson, MS, USA 1Department of Urology, Chinese PLA General Hospital/Chinese PLA Medical School, Beijing, PR China.; 2State Key Laboratory of Kidney Diseases, Chinese PLA General Hospital/Chinese PLA Medical School, Beijing, PR China. Shanghai Institute of Optics and Fine Mechanics, Chinese Academy of Sciences The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi’an Jiaotong University, No.28, Xianning West Road, Xi’an 710049, P.R. China; Bioinspired Engineering and Biomechanics Center (BEBC), Xi’an Jiaotong University, No.28, Xianning West Road, Xi’an 710049, P.R. China Department of Vascular Surgery, Chinese Academy of Medical Sciences and Peking Union Medical College Hospital , No. 1 Shuaifuyuan, Dongdan, Dongcheng District, Beijing 100730, China Jilin Provincial Key Laboratory of Oral Biomedical Engineering School and Hospital of Stomatology Jilin University Changchun 130021 P. R. China Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China.; Institute of Endocrinology and Metabolism, Shandong Academy of Clinical Medicine, Jinan, China.; Shandong Clinical Medical Center of Endocrinology and Metabolism, Jinan, China. Department of Physics and Astronomy, California State University, Northridge, California 91330, United States The State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, People’s Republic of China; High Efficacy Application of Natural Medicinal Resources Engineering Center of Guizhou Province, High Educational Key Laboratory of Guizhou Province for Natural Medicinal Pharmacology and Drug Ability, Key Laboratory of Optimal Utilization of Natural Medicinal Resources, Guizhou Medical University, Guiyang, People’s Republic of China College of Food Science and Engineering, Ocean University of China, PR China CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences and Medical Center, University of Science & Technology of China, Hefei, Anhui, China Life Science College Northeast Agricultural University Harbin 150030 China Wuhan Center for Magnetic Resonance, State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan 430071, China College of Food Science and Engineering; Northwest A&F University; Yangling; P. R. China The General Hospital of Ningxia Medical University, Yinchuan, China Key Laboratory of Magnetic Resonance in Biological Systems; State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics; National Center for Magnetic Resonance in Wuhan; Wuhan Institute of Physics and Mathematics; Innovation Academy for Precision Measurement Science and Technology Anhui Province Key Laboratory of Advanced Catalytic Materials and Reaction Engineering, School of Chemistry and Chemical Engineering Hefei University of Technology Hefei China Collaborative Innovation Center of Tianjin for Medical Epigenetics and Department of Physiology and Pathophysiology, Tianjin Medical University, Tianjin, China; Jet Propulsion Laboratory, California Institute of Technology, 4800 Oak Grove Drive, Pasadena, California 91109-8099, United States The State Key Laboratory of Protein and Plant Gene Research, College of Life Sciences, School of Agriculture Science, Peking University, Beijing 100871, P.R. China National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine Nanjing University of Chinese Medicine Nanjing Jiangsu 210023 China School of Pharmaceutical Sciences, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada; Shanghai Institute of Materia Medica-University of Ottawa Joint Research Center in Systems and Personalized Pharmacology, University of Ottawa, Ottawa, Ontario, Canada; Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, Ontario, Canada School of Pharmacy Guizhou Medical University Guiyang P. R. China Department of Pediatric Surgery, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China Department of Traditional Chinese Medicine, Huadong Hospital, Shanghai 200040, China Jiangsu Engineering Laboratory for Environment Functional Materials, Jiangsu Collaborative Innovation Center of Regional Modern Agriculture & Environmental Protection, School of Chemistry and Chemical Engineering, Huaiyin Normal University, No. 111 West Changjiang Road, Huaian, Jiangsu 223300, China Department of Urology, Clinical Division of Surgery, Chinese PLA General Hospital, Beijing, People's Republic of China. Department of Urology Clinical Division of Surgery Chinese PLA General Hospital Beijing China Liaoning Blood Center, Shenyang, Liaoning 110044, P. R. China. ljp_63@163.com. College of Food Science and Engineering Jilin Agricultural University Changchun China; Jilin Province Product Quality Supervision and Inspection Institute Changchun China Department of Endocrinology Shandong Provincial Hospital affiliated to Shandong University Jinan China; Shandong Clinical Medical Center of Endocrinology and Metabolism Jinan China; Institute of Endocrinology and Metabolism Shandong Academy of Clinical Medicine Jinan China Harbin Engineering University College of Materials Science and Engineering, Liaoning Technical University, Fuxin 123000, China Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling, Hospital of Stomatology, Jilin University, Changchun 130021, P.R. China Institute of Eco-environment and Plant Protection; Shanghai Academy of Agricultural Sciences; Shanghai 201403; China; Shanghai Engineering Research Centre of Low-carbon Agriculture Department of Life Sciences, Imperial College London School of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules, Shanghai Key Laboratory of Electrical Insulation and Thermal Aging, Key Laboratory of Thin Film and Microfabrication (Ministry of Education) Shanghai Jiao Tong University Shanghai 200240 P.R. China Key Laboratory of Vegetable Germplasm Innovation and Utilization of Hebei, Collaborative Innovation Center of Vegetable, College of Horticulture, Hebei Agricultural University, Baoding 071001, China Department of Stem Cell Biology, Atomic Bomb Diseases Institute, Nagasaki University, Nagasaki 852‑8523, Japan Department of Neurobiology, Institute of Neurosciences, The Fourth Military Medical University, Xi'an, People's Republic of China; Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden Department of Physiology and Pathophysiology, Tianjin Medical University, Tianjin, 300070, China Department of Endodontics School and Hospital of Stomatology Tianjin Medical University Tianjin 300070 P. R. China Department of Thoracic Oncology, Sun Yat‑sen University Cancer Center, Guangzhou, Guangdong 510060, P.R. China Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan 430071, People's Republic of China The Affiliated Hospital of Medical School, Ningbo University, Ningbo, Zhejiang Province, China; Section of Hematology/Oncology, Department of Medicine, University of Illinois, Chicago, IL, USA Institute of Chinese Sturgeon, China Three Gorges Corporation, Yichang, Hubei, China and; Hubei Key Laboratory of Three Gorges Project for Conservation of Fishes, Institute of Chinese Sturgeon, China Three Gorges Corporation, Yichang, Hubei, China National Center for Nanoscience and Technology, Chinese Academy of Sciences, Beijing 100190, China. Jiangxi Provincial Key Laboratory for Ophthalmology, Jiangxi Clinical Research Center of Ophthalmic Disease, Affiliated Eye Hospital of Nanchang University, 463 Bayi Road, Nanchang 330006, China Tianjin Key Laboratory of Molecular Optoelectronic Science Department of Chemistry Tianjin University Tianjin 300354 P. R. China Department of Gastroenterology, The First Affiliated Hospital of Xi’an Jiaotong University, No. 277, West Yanta Road, Yanta District, Xi’an, Shaanxi 710061, P. R. China; National Local Joint Engineering Research Center for Precision Surgery and Regenerative Medicine, The First Affiliated Hospital of Xi’an Jiaotong University, No. 277, West Yanta Road, Yanta District, Xi’an, Shaanxi 710061, P. R. China Key Laboratory of Advanced Structural Materials; Ministry of Education & Advanced Institute of Materials Science Changchun University of Technology Changchun; China State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China), Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, 15 Yu Cai Road, Guilin, 541004, China Tianjin Key Lab. of Metabolic Diseases and Department of Physiology, Tianjin Medical University, Tianjin 300070, China. Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University; The Key Laboratory of Major Autoimmune Diseases, Anhui Medical University Department of Oral Implantology The Fourth Affiliated Hospital of Nanchang University, School of Medicine, Nanchang University Nanchang China Department of Urology, Chinese People's Liberation Army General Hospital, Beijing 100853, China. Email: xzhang301@126.com. Department of Internal Medicine, Division of Clinical and Translational Sciences, The University of Texas Health Science Center at Houston, Houston, TX, USA; Biostatistics/Epidemiology/Research Design (BERD) Component, Center for Clinical and Translational Sciences (CCTS), University of Texas Health Science Center at Houston, Houston, TX, USA State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China College of Engineering Center for Design and Manufacturing Excellence, Ohio State University, Columbus, Ohio, USA. Department of Neurology Neurological Institute Graduate School of Medical Sciences Kyushu University Fukuoka Japan; Translational Neuroscience Center Graduate School of Medicine International University of Health and Welfare Okawa Japan Hubei Key Laboratory of Sport Training and Monitoring, College of Health Science, Wuhan Sports University, Wuhan 430079, China. Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, China;; The Key Laboratory of Major Autoimmune Diseases, Anhui Medical University, Hefei, Anhui, China; Department of Chemistry, University of Nebraska—Lincoln, Lincoln, Nebraska 68588, United States Department of Hand Surgery, Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, China Hefei University of Technology Department of Rehabilitation, Wangjing Hospital of China Academy of Chinese Medical Science, Beijing, China School of Life Sciences Tianjin University Tianjin 300072 P. R. China Edmond H. Fischer Signal Transduction Laboratory, College of Life Sciences, Jilin University, Changchun, 130012, China CAS Key Laboratory for Biomedical Effects of Nanomaterials & Nanosafety and CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, University of Chinese Academy of Sciences, Beijing 100190, People’s Republic of China; Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, School of Medicine, Northwest University, Xi’an 710069, People’s Republic of China Department of Thoracic Surgery State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat‐sen University Cancer Center Guangzhou Guangdong China Nanjing University of Chinese Medicine, Nanjing, China Key Laboratory of Polar Materials and Devices, Ministry of Education, Department of Electronics, East China Normal University, Dongchuan Road 500, Shanghai 200241, P. R. China Aerospace Information Research Institute, Chinese Academy of Sciences, Beijing 100190, China; Key Laboratory of Electromagnetic Radiation and Sensing Technology, Chinese Academy of Sciences, Beijing 100190, China; School of Physical Science and Technology, Inner Mongolia University, Hohhot 010021, China College of Life Sciences and Engineering, Foshan University, Foshan, People’s Republic of China The Modernization Engineering Technology Research Center of Ethnic Minority Medicine of Hubei Province, College of Pharmacy, South-Central University for Nationalities, Wuhan 430074, China 0 School of Life Sciences and Engineering, Foshan University, Changchun, China School of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of Technology, Wuhan 430070, China Center for Translational and Clinical Studies, University of Texas Health Science Center, Houston, TX. Research Institute of Subtropical Forestry of Chinese Academy of Forestry , Hangzhou, Zhejiang 311400 , China State Key Laboratory of Magnetic Resonance and Atomic Molecular Physics, Key Laboratory of Magnetic Resonance in Biological Systems, National Center for Magnetic Resonance in Wuhan, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan National Laboratory for Optoelectronics, Wuhan 430071, China Fujian Institute of Research on the Structure of Matter; Chinese Academy of Sciences; Fuzhou 350002; China Transfusion Medicine Institute Liaoning Blood Center Shenyang Liaoning China; Liaoning Provincial Key Laboratory for Blood Safety Research Shenyang Liaoning China; Key Laboratory for Blood Safety Research of Shenyang Shenyang Liaoning China Institute of Neuroscience and State Key Laboratory of Neuroscience, School of Chemical Engineering, Zhengzhou University, Zhengzhou 450001, Henan, China Department of Chemical Engineering, Tsinghua University, Beijing 100084, China. School of Medicine, Tsinghua University, Beijing 100084, China. Beijing Engineering Research Center for Experimental Animal Models of Human Diseases Institute of Laboratory Animal Science, Peking Union Medical College, Chinese Academy of Medical Sciences Beijing China Department of Nutrition and Health, Beijing Advanced Innovation Center for Food, Nutrition and Human Health, Key Laboratory of Precision Nutrition and Food, Quality, China Agricultural University Jiangsu Engineering Laboratory for Environmental Functional Materials, School of Chemistry and Chemical Engineering, Huaiyin Normal University, Huaian, Jiangsu 223300, China Duke University; Durham; USA Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA. Tianjin Key Laboratory of Metabolic Diseases, Collaborative Innovation Center of Tianjin for Medical Epigenetics, Department of Physiology and Pathophysiology, Tianjin Medical University, Tianjin, China. China Information Communication Technologies Group Corporation; National Optoelectronics Innovation Center School of Biomedical Engineering, Capital Medical University , No. 10, Xitoutiao, YouAnMen, Fengtai District, Beijing 100069 , China Department of General Surgery, Suzhou Science & Technology Town Hospital, Suzhou 215006, China; Department of General Surgery, Suzhou Hospital Affiliated to Nanjing Medical University, Suzhou 215006, China Department of Public Service, The First Hospital of China Medical University, Shenyang, P. R. China Jiangsu Key Laboratory of Medical Science and Laboratory Medicine School of Medicine Jiangsu University Zhenjiang Jiangsu 212013 China Faculty of Materials and Manufacturing, Beijing Key Lab of Microstructure and Properties of Advanced Materials, Beijing University of Technology, Beijing 100124, P. R. China Division of Biotechnology CAS Key Laboratory of SSAC Dalian Institute of Chemical Physics Chinese Academy of Sciences Dalian 116023 China Key Laboratory of Zoonosis Research of Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine, Jilin University, Changchun 130062, China From the Departments of Radiology, and State Key Laboratory of Oncology, Guangzhou, China; Department of Nuclear Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China; Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China Department of Preventive Medicine, School of Public Health, Hangzhou Normal University, Hangzhou, China School of Science and Ministry of Industry and Information Technology Key Laboratory of Micro-Nano Optoelectronic Information System, Harbin Institute of Technology, Shenzhen, 518055, China Harbin Medical University Harbin Heilongjiang China School of Function Food and Wine, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang 110016, China Key Laboratory of Micro-Nano Measurement, Manipulation and Physics (Ministry of Education), School of Physics, Beihang University, Beijing 100191, China Center for Anatomy and Functional Morphology, Mount Sinai School of Medicine, New York, New York Department of Ultrasonography, Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing 100102, China Department of Anesthesiology, McGovern Medical School UT Health Houston Houston Texas USA Key Laboratory of Industrial Biocatalysis, Ministry of Education Department of Chemical Engineering Center of Synthetic and Systems Biology Tsinghua‐Peking Center of Life Sciences Tsinghua University Beijing China Division of Experimental Diabetes and Aging, Department of Geriatrics and Adult Development, Mount Sinai School of Medicine, New York, New York 10029 Department of Urology, State Key Laboratory of Kidney Diseases, Chinese People’s Liberation Army (PLA) General Hospital/Chinese PLA Medical Academy, Beijing, China (mainland) Qinhuangdao Shanhaiguan Limited Company Qinhuangdao 066200, China. Central Laboratory, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China; Department of Neurosurgery, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China; Department of Molecular Diagnostics, Sun Yat-sen University Cancer Center, Guangzhou 510060, China Department of Head Neck and Thyroid Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital Zhengzhou Henan Province People's Republic of China Department of Thoracic Surgery, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health , Beijing, China; Department of Thoracic Surgery, National Clinical Research Center for Respiratory Disease, Ministry of Science and Technology , Beijing, China; Department of Paediatric Surgery, Key Laboratory of Major Diseases in Children, Ministry of Education , Beijing, China; Department of Thoracic Surgery, Beijing Engineering Research Center of Paediatric Surgery , Beijing, China National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, China. State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro‐products Ningbo University Ningbo China; Laboratory of Biochemistry and Molecular Biology School of Marine Sciences Meishan Campus Ningbo University Ningbo China; Key Laboratory of Applied Marine Biotechnology of Ministry of Education Meishan Campus Ningbo University Ningbo China Department of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan, China Department of Physics and Astronomy; California State University; Northridge; USA Key Laboratory of Human Functional Genomics of Jiangsu Province, Department of Biochemistry and Molecular Biology, Nanjing Medical University, Nanjing, Jiangsu, China School of Chemical Engineering and Technology, Hebei University of Technology, 8 Guangrong Road, Hongqiao District, Tianjin China Department of Mammary Disease The Second affiliated Hospital of Guangzhou University of Chinese Medicine Guangzhou Guangdong China Faculty of Urology, Third Medical Center, Chinese PLA General Hospital, Beijing, China College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, Daqing, Heilongjiang Province, People's Republic of China. Department of Periodontology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine; College of Stomatology, Shanghai Jiao Tong Univerisity; National Center for Stomatology; National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology , Shanghai, China; Laboratory of Oral Microbiota and Systemic Diseases, Shanghai Research Institute of Stomatology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine; College of Stomatology, Shanghai Jiao Tong Univerisity; National Center for Stomatology; National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology , Shanghai, China Department of Nutrition School of Public Health Sun Yat‐sen University (Northern Campus) Guangzhou P. R. China Department of Endodontics School and Hospital of Stomatology, Tianjin Medical University Tianjin China School of Architecture and Urban Planning, Shandong Jianzhu University, Jinan, China Structure Research Lab, Department of Chemistry, University of Science & Technology of China, Hefei, Anhui 230026, People's Republic of China Sun Yat-sen University Cancer Center, Guangzhou, China *Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China;; †Key Laboratory of Tropical Disease Control, Ministry of Education, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China; and Department of Medicine, University of Illinois Hospitals and Health Sciences System, Chicago, IL; Department of Ecology and Evolution, University of Chicago, Chicago, Illinois, United States of America. State Key Laboratory of Silicon Materials School of Materials Science and Engineering Zhejiang University Hangzhou 310027 China Jiangsu Breast Disease Center The First Affiliated Hospital with Nanjing Medical University 300 Guangzhou Road Nanjing 210029 China Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing 100084, China; Key Laboratory of Industrial Biocatalysis, Ministry of Education, Department of Chemical Engineering, Tsinghua University, Beijing 100084, China Key Laboratory of Pesticide & Chemical Biology of Ministry of Education Institute of Environmental & Applied Chemistry College of Chemistry Central China Normal University Wuhan 430079 P. R. China University of Colorado Department of Chemistry and Biochemistry, , Boulder, Colorado 80309-0215 and Jet Propulsion Laboratory, , Pasadena, California 91109-8099; California Institute of Technology Department of Chemistry and Biochemistry, , Boulder, Colorado 80309-0215 and Jet Propulsion Laboratory, , Pasadena, California 91109-8099 School of Materials Science and Engineering, Nankai University, Tianjin 300350, People’s Republic of China Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China National Center for International Joint Research of Electronic Materials and Systems, Henan Key Laboratory of Laser and Opto-electric Information Technology, School of Information Engineering, Zhengzhou University, Zhengzhou 450052, People’s Republic of China Department of Internal Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX. Department of Endocrinology and Metabolism, Shandong Provincial Hospital affiliated to Shandong University, Jinan, Shandong, 250021, China; Institute of Endocrinology, Shandong Academy of Clinical Medicine, Jinan, Shandong, 250021, China; Shandong Clinical Medical Center of Endocrinology and Metabolism, Jinan, Shandong, 250021, China Department of Cardiac Surgery, The General Hospital of Northern Theater Command, Shenyang, Liaoning, China Department of Orthopaedics, Shanghai Pudong Hospital Fudan University, Pudong Medical Center Shanghai China Singlomics (Beijing DanXu Biopharmaceuticals) Co., Ltd. Beijing China CAS Key Laboratory of Plant Germplasm Enhancement and Specialty Agriculture, Wuhan Botanical Garden, Chinese Academy of Sciences, Wuhan, Hubei, China College of Forestry, Northwest A&F University, Yangling 712100, Shaanxi, China. Department of Entomology, Nanjing Agricultural University, Nanjing, Jiangsu 210095, China Department of Neurosurgery, Ningxia Medical University, Yinchuan, Republic of China Ottawa Institute of Systems Biology, Department of Biochemistry, Microbiology and Immunology, University of Ottawa, 451 Smyth Rd., Ottawa, Ontario, Canada, K1H8M5 State Key Laboratory of Kidney Diseases, Department of Urology; Chinese People's Liberation Army Medical School, Chinese People's Liberation Army General Hospital; Beijing China Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138 Division of Anti-tumor Pharmacology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China Jiangsu Key Laboratory of Medical Science and Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang 212013, Jiangsu, China Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China. Core Facility for Protein Research Institute of Biophysics Chinese Academy of Sciences Beijing China Key Laboratory of Magnetic Resonance in Biological Systems, State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National Center for Magnetic Resonance in Wuhan, Wuhan Institute of Physics and Mathematics, Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences-Wuhan National Laboratory for Optoelectronics, 430071 Wuhan, People’s Republic of China;; University of Chinese Academy of Sciences, 100049 Beijing, People’s Republic of China; CAS Key Laboratory of Separation Science for Analytical Chemistry; Dalian Institute of Chemical Physics; Chinese Academy of Sciences; Dalian; China 1Section of Hematology/Oncology, Department of Medicine, University of Illinois at Chicago, Chicago, IL Hunan Institute of Animal Science and Veterinary Medicine, Changsha, China; Hunan Co-Innovation Center of Animal Production Safety (CICAPS), Changsha, China Department of Urology/State Key Laboratory of Kidney Diseases, Chinese PLA General Hospital/PLA Medical School, Beijing, China Key Laboratory of Pesticide & Chemical Biology of Ministry of Education, Institute of Environmental & Applied Chemistry, College of Chemistry, Central China Normal University, Wuhan 430079, P. R. China Department of Oral and Maxillofacial‐Head and Neck Oncology, Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai China; College of Stomatology Shanghai Jiao Tong University Shanghai China; National Center for Stomatology Shanghai China; National Clinical Research Center for Oral Diseases Shanghai China; Shanghai Key Laboratory of Stomatology Shanghai China Institute of Neuroscience and State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, China; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, 155 Yang Qiao Xi Lu, Fuzhou, Fujian 350002, China; University of Chinese Academy of Sciences, Beijing 100049, China; Cancer Research Centre of Marseille (CRCM), CNRS UMR7258, INSERM U1068, Institut Paoli - Calmettes, Aix-Marseille Université UM105 F-13009, Marseille, France Department of Gastroenterology, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, China Univ Rennes; INSA Rennes; CNRS; ISCR (Institut des Sciences Chimiques de Rennes) – UMR 6226; F-35000 Rennes State Key Laboratory of High-efficiency Utilization of Coal and Green Chemical Engineering; School of Chemistry and Chemical Engineering; Ningxia University; Yinchuan; P.R. China State Key Laboratory of Crop Genetics and Germplasm Enhancement, Nanjing Agricultural University, Nanjing, 210095, Jiangsu, China. School of Flexible Electronics (Future Technologies) & Institute of Advanced Materials (IAM) Key Laboratory of Flexible Electronics (KLOFE) Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM) Nanjing Tech University (Nanjing Tech) Nanjing 211816 China Master of Science in Biotechnology Program; McCormick School of Engineering; Northwestern University; Evanston; USA Department of Clinical Veterinary Medicine, College of Veterinary Medicine Jilin University Changchun Jilin Province China Department of Urology, Chinese PLA General Hospital/Chinese PLA Medical Academy, Beijing 100036, P.R. China Key Laboratory of Medical Science and Laboratory Medicine of Jiangsu Province, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu 212013, P.R. China Department of Thoracic Surgery Beijing Children’s Hospital Capital Medical University National Center for Children’s Health Beijing China CAS Key Laboratory for Biological Effects of Nanomaterials & Nanosafety, National Center for Nanoscience and Technology, No. 11 Beiyitiao, Zhongguancun, Beijing 100190, China College of Life Science, Northeast Agricultural University, Harbin 150030, China School of Microelectronics at University of Science and Technology of China, Hefei, Anhui, China Department of Hand Surgery, The Second Hospital of Qinhuangdao, Changli, Qinhuangdao, P.R. China Department of Stem Cell Biology Nagasaki University Graduate School of Biomedical Sciences Nagasaki Japan; Department of Stem Cell Biology, Atomic Bomb Disease Institute Nagasaki University Nagasaki Japan Department of Neurology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics National Laboratory for Optoelectronics National Center for Magnetic Resonance (Wuhan) Key Laboratory of Magnetic Resonance in Biological Systems Wuhan Institute of Physics and Mathematics Chinese Academy of Sciences Wuhan 430071 China; University of Chinese Academy of Sciences Beijing 100049 China Department of Vascular Surgery,PUMC Hospital,CAMS and PUMC,Beijing 100730,China. Key Laboratory of Medical Science and Laboratory Medicine of Jiangsu Province, School of Medicine, Jiangsu University, Zhenjiang, P.R. China Department of Urology, State Key Laboratory of Kidney Diseases, Chinese PLA General Hospital/PLA Medical School, Beijing, China; Department of Urology, First Affiliated Hospital of Nanchang University (LC), Nanchang, China Radiation Epidemiology Research Center, Institute of Radiation Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College , Tianjin , China; Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical University , Tianjin , China Key Laboratory of Laboratory Medicine of Jiangsu Province, School of Medicine Department of Pediatrics, Affiliated Hospital of Zhangzhou, Fujian Medical University, Zhangzhou 363000, China Beijing National Laboratory for Condensed Matter Physics & Institute of Physics, Chinese Academy of Sciences, Beijing 100190, China; Department of Physics, Capital Normal University, Beijing 100048, China School of Pharmacy; Shanghai Jiaotong University; Shanghai China Physical Education College, Hebei Normal University, Shijiazhuang, China Department of Geriatrics, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, P.R. China Center for Membrane and Water Science & Technology, Collaborative Innovation Center of Membrane Separation and Water Treatment of Zhejiang Province, Zhejiang University of Technology, Hangzhou 310014, China Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University , Hefei , China; School of Public Health, The Key Laboratory of Major Autoimmune Diseases, Anhui Medical University , Hefei , China Key Laboratory of Laboratory Medicine of Jiangsu Province, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu, China School of Resources and Environmental Science, Wuhan University, Wuhan 430079, P.R. China Laboratory of Clean Energy Chemistry and Materials, State Key Laboratory of Solid Lubrication, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, People’s Republic of China Transfusion Medicine Institute Liaoning Blood Center Shenyang China; Liaoning Provincial Key Laboratory for Blood Safety Research Shenyang China; Key Laboratory for Blood Safety Research of Shenyang Shenyang China College of Statistics and Data Science Beijing University of Technology Beijing China From the Holtom-Garrett Program in Neuroimmunology and Multiple Sclerosis Center, Departments of Neurology (A.K.H., D.N.I., B.M.S.), Biostatistics (L.W.), and Radiology (A.S.), University of Michigan, Ann Arbor; Neurology Service (B.M.S.), VA Ann Arbor Healthcare System, MI; Department of Statistics and Actuarial Science (P.H.), University of Waterloo, Canada; Department of Mathematics and Statistics (X.Z.), Bowling Green State University, OH; and Department of Imaging Sciences (S.E.), University of... Center for Clinical and Translational Sciences, University of Texas Health Science Center at Houston, Houston, TX; University of California Los Angeles, CA, 90095, USA Department of Hepato‐Biliary‐Pancreatic Surgery Henan Provincial People's Hospital People's Hospital of Zhengzhou University Zhengzhou Henan 450003 P. R. China Department of Urology, PLA General Hospital, Beijing, China. State Key Laboratory of Respiratory Disease National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health the First Affiliated Hospital of Guangzhou Medical University Guangzhou China Ministry of Industry and Information Technology Department of Urology/State Key Laboratory of Kidney Diseases, Chinese People’s Liberation Army (PLA) General Hospital/PLA Medical School, Beijing, China (mainland) Department of Molecular Medicine and Neurodegeneration New Medicines Center, The Scripps Research Institute, La Jolla, California, USA. Key Laboratory of Zoonosis, Ministry of Education, Institute of Zoonosis, Jilin University, Xi'an Da Lu 5333, Changchun 130062, China Senior Department of Urology, The Third Medical Center of PLA General Hospital, Beijing, China Department of Gastroenterology and Hepatology of Tianjin Third Central Hospital, Tianjin 300170, P.R. China Key Laboratory of Magnetic Resonance in Biological Systems State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics Wuhan Center for Magnetic Resonance Wuhan Institute of Physics and Mathematics Chinese Academy of Sciences Wuhan P.R. China University of Science and Technology of China, Hefei, China Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, MOE Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, P.R. China Tianjin Key Laboratory of Metabolic Diseases and Department of Physiology, Tianjin Medical University, Tianjin 300070, China. Department of Urology, the Third Medical Center, Chinese PLA General Hospital, Beijing, China. Jiangsu Key Laboratory of Medical Science and Laboratory Medicine School of Medicine Jiangsu University Zhenjiang Jiangsu China Howard Hughes Medical Institute and Departments of Cell Biology and Biochemistry, Duke University Medical Center, Durham, North Carolina 27710 Department of Neurology, The Affiliated Hospital of Medical College Qingdao University, Qingdao, China Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210028, China; Nanjing Jiangning Hospital of TCM, Nanjing 211100, China Department of Chemistry and Waterloo Institute for Nanotechnology, University of Waterloo, 200 University Avenue West, Waterloo, Ontario, Canada N2L 3G1 Key Laboratory of Local Animal Genetic Resources Conservation and Bio‐Breeding of Anhui Province College of Animal Science and Technology Anhui Agricultural University Hefei China Department of Chemistry & Biochemistry, University of Colorado, Boulder, Colorado 80309-0215, Institute for Physical Chemistry, University of Basel, Klingelbergstrasse 80, CH-4056 Basel, Switzerland, Jet Propulsion Laboratory, California Institute of Technology, 4800 Oak Grove Drive, Pasadena, California 91109-8099, National Renewable Energy Laboratory, 1617 Cole Boulevard, Golden, Colorado 80401, Earth and Environmental Sciences Division, Los Alamos National Laboratory, Mail Stop D462, Los Alamos, New... Department of Hepatobilliary and Pancreatic surgery Zhengzhou University People's Hospital, Henan Provincial People's Hospital Zhengzhou China Bejing Epigen Medical Institute Beijing China Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital of Capital Medical University, Hougou Lane No 17, Chongnei Street, Beijing 100005, China Liaoning Blood Center, Shenyang 110044, Liaoning Province, China. Key Laboratory of Tropical Translational Medicine of Ministry of Education, Hainan Key Laboratory for Research and Development of Tropical Herbs, School of Pharmacy, Hainan Medical University Key Laboratory of Synthetic and Biological Colloids Ministry of Education School of Chemical and Material Engineering Jiangnan University Wuxi 214122 China Department of Nuclear Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University Health Science Center, State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University, NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Beijing, China (L.Y., H.W., R.D., Z.L., X.Z., Z.G., Z.C., Y.S., F.Y., Y.F., W.K.). College of Oil Engineering, Chongqing University of Science and Technology, Chongqing 401331, China Department of Endodontics Tianjin Medical University School and Hospital of Stomatology Tianjin China State Key Lab of Crop Genetics and Germplasm Enhancement, Cytogenetics Institute, College of Agriculture Nanjing Agricultural University/JCIC‐MCP Nanjing Jiangsu China School of Chemistry and Chemical Engineering Yangzhou University Yangzhou 225002 P. R. China Department of Orthopedics the Third Hospital of Hebei Medical University Shijiazhuang China; Key Laboratory of Biomechanics of Hebei Province Shijiazhuang China; Department of Hand Surgery the Third Hospital of Hebei Medical University Shijiazhuang China State Key Laboratory of Polymer Physics and Chemistry; Changchun Institute of Applied Chemistry; Chinese Academy of Sciences; Changchun; China School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210023, China Department of Gastroenterology and Hepatology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China State Key Laboratory of Oncology in Southern China, Guangzhou, Guangdong 510060, P. R. China. Department of Hemodialysis, Weifang Hospital of Traditional Chinese Medicine, Weifang, China; and Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu City 610072, Sichuan Province, P.R. China. State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology (SKLUWRE, HIT), P.O. Box 2614, 202 Haihe Road, Harbin 150090, China Department of Pediatric Cardiology, Guangdong Academy of Medical Sciences, Guangzhou 510100, China. Department of Internal Medicine, McGovern Medical School University of Texas Health Science Center Houston Texas USA State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied Chemistry Chinese Academy of Sciences 130022 Changchun P. R. China Department of Endocrinology, Provincial Hospital Affiliated to Shandong University, Jinan 250021, China; Institute of Endocrinology, Shandong Academy of Clinical Medicine, Jinan 250021, China; Department of Endocrinology, Provincial Hospital Affiliated to Shandong University, Jinan 250021, China; Institute of Endocrinology, Shandong Academy of Clinical Medicine, Jinan 250021, China National First-Class Key Discipline for Traditional Chinese Medicine of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China Clinical Division of Surgery Department of Urology Chinese PLA General Hospital Beijing China Institute of Human Virology Zhongshan School of Medicine Sun Yat‐sen University Guangzhou Guangdong China; Key Laboratory of Tropical Disease Control of Ministry of Education Zhongshan School of Medicine Sun Yat‐sen University Guangzhou Guangdong China Center for Biologics Evaluation Biologic and Radiopharmaceutical Drugs Directorate, Health Products and Food Branch, Health Canada Ottawa Canada Center for Membrane and Water Science & Technology, Institute of Oceanic and Environmental Chemical Engineering, State Key Lab Breeding Base of Green Chemical Synthesis Technology, Zhejiang University of Technology, 310014 Hangzhou, China School of Environment; Tsinghua University; Beijing; PR China; State Key Joint Laboratory of Environmental Simulation and Pollution Control Department of Nuclear Medicine Sun Yat‐sen University Cancer Center Guangzhou China School of Nursing Jilin University Changchun China Division of Experimental Diabetes and Aging (Z.Z., X.Z., C.Z., J.C., J.S., K.S., Z.A.M.), Department of Geriatrics and Palliative Medicine, Mount Sinai School of Medicine, New York, New York 10029 Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P.R. China. Department of Ophthalmology, Shanghai Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Beijing, 100190, People’s Republic of China School of Chemical Engineering, Zhengzhou University, Zhengzhou 450001, Henan, China; School of Materials Science and Engineering, Institute of New Energy Material Chemistry, Renewable Energy Conversion and Storage Center (ReCast), Key Laboratory of Advanced Energy Materials Chemistry (Ministry of Education), Nankai University, Tianjin 300350, China State Key Laboratory of Marine Resource Utilization in South China Sea; Hainan University; Haikou 570228; China; School of Materials Science and Engineering College of Agronomy and Horticulture, Jiangsu Vocational College of Agriculture and Forestry, Nanjing, China Theoretical and Applied Mechanics Program; Northwestern University; Evanston; USA Departments of Biology, of Mechanical & Mechatronics Engineering, and of Chemistry, University of Waterloo, Ontario N2L 3G1, and Worsfold Water Quality Center, Trent University, Peterborough, Ontario K9J 7B8, Canada School of Safety Engineering, Shenyang Aerospace University, Shenyang 110136, China Department of Chemistry, Rutgers University, Newark, New Jersey 07102, United States Division of Cardiology Department of Geriatrics The First Affiliated Hospital of Chongqing Medical University Chongqing China Department of Urology, The General Hospital of the People’s Liberation Army, Beijing, China Department of Urology, Clinical Division of Surgery, Chinese PLA General Hospital, Beijing, China.; Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Road, Shanghai, 200032, China Division of Hematology and Oncology, Department of Medicine, Comprehensive Sickle Cell Center, and Co-Innovation Center for Sustainable Forestry in Southern China, Nanjing Forestry University, Nanjing 210037, China; Bamboo Research Institute, Nanjing Forestry University, Nanjing 210037, China; College of Life Sciences, Nanjing Forestry University, Nanjing 210037, China Department of Electrical Engineering and Computer Science Massachusetts Institute of Technology Cambridge MA 02139 USA Department of Biology, University of Waterloo, Ontario, N2L 3G1, Canada Department of Polymer Science and Engineering, School of Chemistry and Chemical Engineering, State Key Laboratory of Coordination Chemistry, Nanjing National Laboratory of Microstructures, Nanjing University, Nanjing 210093, China Collaborative Innovation Center of Tianjin for Medical Epigenetics, Tianjin Key Laboratory of Medical Epigenetics, and Department of Physiology and Pathophysiology Tianjin Medical University Tianjin China Beijing National Laboratory for Condensed Matter Physics and Institute of Physics; Chinese Academy of Sciences; Beijing 100190, People's Republic of China Shenzhen Key Laboratory of Reproductive Immunology for Peri‐implantation, Shenzhen Zhongshan Institute for Reproduction and Genetics, Fertility Center Shenzhen Zhongshan Urology Hospital Shenzhen Guangdong China Dalian National Laboratory for Clean Energy iChEM Dalian Institute of Chemical Physics Chinese Academy of Sciences Dalian 116023 China; Key Laboratory of Applied Surface and Colloid Chemistry Ministry of Education Shaanxi Key Laboratory for Advanced Energy Devices Shaanxi Engineering Lab for Advanced Energy Technology School of Materials Science and Engineering Shaanxi Normal University Xi'an 710119 China; University of Chinese Academy of Sciences Beijing 100049 China Department of Pathology, First Clinical Hospital, Harbin Medical University, Harbin 150001, PR China. Institute of Brain-Intelligence Science and Technology, Zhangjiang Lab, China; Shanghai Center for Brain Science and Brain-Inspired Technology, China Department of Chemistry and Molecular Biology, School of Life Science and Technology Harbin Normal University Harbin People's Republic of China Tianjin Key Laboratory of Metabolic Diseases and Department of Physiology and Pathophysiology Tianjin Medical University Tianjin China Department of Mathematics, University of Maryland, College Park, MD, USA China-Japan Union Hospital of Jilin University, 126 Xiantai St, Erdao, 130033, Changchun, Jilin, China *Tsinghua–Peking Center for Life Sciences, Laboratory of Dynamic Immunobiology, School of Medicine, Tsinghua University, Beijing 100084, People’s Republic of China; 2Key Laboratory of Zoonosis, Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun, Jilin Province, People’s Republic of China Laboratory of Functional Nanomaterials and Devices; School of Materials Science and Engineering; Hefei University of Technology; Hefei 230009; China Department of Urology China PLA General Hospital Beijing China Department of Cardiology and Laboratory of Gene Therapy for Heart Diseases, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu, Sichuan, China Department of Electronic Science and Technology, University of Science and Technology of China, Hefei, Anhui, China Department of Vascular Surgery, Peking Union Medical College Hospital, Beijing 100730, China Key Laboratory of Human Disease Comparative Medicine, NHFPC, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences & Comparative Medical Center, Peking Union Medical College, Building 5, Panjiayuan Nanli, Chaoyang District, Beijing 100021, China; Department of Human Anatomy , College of Basic Medical Sciences, China Medical University, No.77 Puhe Road, Shenyang North New Area, Shenyang 110122, Liaoning Province , P.R. China Department of Molecular Medicine and Neurodegeneration New Medicines Center The Scripps Research Institute La Jolla CA 92037 USA Department of Physiology and Pathophysiology, Tianjin Medical University, Tianjin, China Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials, Ministry-of-Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules & College of Chemistry & Chemical Engineering, Hubei University, Wuhan, 430062, P. R. China Institute for Preservation and Conservation of Chinese Ancient Books, Fudan University Library, Fudan University, 220 Handan Road, Shanghai 200433, China the Chinese Academy of Sciences CAS Key Laboratory of Plant Germplasm Enhancement and Specialty Agriculture, Wuhan Botanical Garden, , Wuhan 430074, Hubei, China; University of Chinese Academy of Sciences College of Life Sciences, , Beijing 100049, China 1Collaborative Innovation Center for Cancer Medicine, State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, China. State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-Sen University, Guangzhou 510060, China Key Laboratory of Molecular Clinical Pharmacology & Guangzhou Institute of Cardiovascular Disease, Guangzhou Medical University, Guangzhou, Guangdong 511436, China Hand Surgery Department, Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050000, China. Beijing Institute of Collaborative Innovation, Beijing, 100094, China Department of Urology, China People's Liberation Army General Hospital, Beijing, People's Republic of China Centre for Quantum Physics, Key Laboratory of Advanced Optoelectronic Quantum Architecture and Measurement (MOE), School of Physics, Beijing Institute of Technology, Beijing 100081, China; Yangtze Delta Region Academy of Beijing Institute of Technology, Jiaxing, 314019, China; Beijing Key Lab of Nanophotonics and Ultrafine Optoelectronic Systems, School of Physics, Beijing Institute of Technology, Beijing 100081, China Beijing National Laboratory for Condensed Matter Physics Chinese Academy of Sciences Beijing 100190 China Department of Urological Surgery, Chinese PLA General Hospital, Beijing, China; From the Department of Anesthesiology, The University of Texas Health Science Center at Houston, McGovern Medical School, Houston, Texas (J.W.L., J.L.B., X.Y., J.L., H.K.E.); Department of Anesthesiology and Intensive Care Medicine, Tübingen University Hospital, Eberhard-Karls University Tübingen, Tübingen, Germany (M.K.); Department of Anesthesiology, University of New Mexico School of Medicine, Clinical Metabolomics Center, China Pharmaceutical University, Nanjing, Jiangsu 210009, P. R. China College of Materials Science and Engineering Key Laboratory of Advanced Functional Materials Ministry of Education Beijing University of Technology Beijing 100124 China Department of Orthopedics, Affiliated Hospital of Jining Medical University, Jining City, Shandong Province, China. Department of Gastroenterology and Hepatology, Second Affiliated Hospital of Harbin Medical University, Harbin, China School of Public Health Hangzhou Normal University Hangzhou People's Republic of China Core Facility for Protein Research, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China Department of Nursing Cancer Hospital of China Medical University, Liaoning Cancer Hospital Liaoning China NEST Laboratory, Department of Chemistry, College of Science, Shanghai University, Shanghai 200444, China McGill University 2 Department of Biochemistry and Goodman Cancer Research Centre , , Montreal, H3A 1A3 , Canada Department of Electrical and Electronic Engineering, Southern University of Science and Technology, Shenzhen, Guangdong 518055, China a College of Resources and Environmental Engineering, Wuhan University of Science and Technology, Hubei, China; b Hubei Key Laboratory for Efficient Utilization and Agglomeration of Metallurgic Mineral Resources, Wuhan University of Science and Technology, Wuhan, China Department of Computer and Information Sciences and Engineering, University of Florida, Gainesville, FL 32611, USA. xuzhang@cise.ufl.edu Key Laboratory of Functional Polymer Materials, Institute of Polymer Chemistry, Nankai University, Tianjin 300071, China School of Chemistry and Chemical Engineering, Liaoning Normal University, Dalian 116029, P. R. China Department of Neurology Beijing Engineering Research Center for Experimental Animal Models of Human Diseases, Institute of Laboratory Animal Science, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China Department of Internal Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston (primary) State Key Laboratory of Characteristic Chinese Medicine Resource of Southwest China, School of Pharmacy Chengdu University of Traditional Chinese Medicine Chengdu P. R. China Department of Medicine University of Illinois at Chicago Chicago Illinois USA Key Laboratory of Human Disease Comparative Medicine National Health Commission of China (NHC) Institute of Laboratory Animal Science Peking Union Medicine College Chinese Academy of Medical Sciences Beijing China; Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases Institute of Laboratory Animal Science Peking Union Medicine College Chinese Academy of Medical Sciences Beijing China College of Materials Science and Engineering; Liaoning Technical University; Fuxin 123000; P. R. China Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China The Education Ministry Key Lab of Resource Chemistry Shanghai Key Laboratory of Rare Earth Functional Materials Shanghai Frontiers Science Center of Biomimetic Catalysis Shanghai Normal University Shanghai 200234 China School of Material Science and Engineering; Jiangxi University of Science and Technology; Ganzhou; P. R. China State Key Laboratory of Oncology in South China, Guangzhou, China; Department of Nuclear Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China; Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China School of Basic Medical Sciences, Anhui Medical University, Hefei, 230032, Anhui, China Guangdong Provincial Key Laboratory of Semiconductor Optoelectronic Materials and Intelligent Photonic Systems, School of Materials Science and Engineering, Harbin Institute of Technology (Shenzhen), Shenzhen 518055, China Division of Hematology and Oncology Department of Medicine University of Illinois at Chicago Chicago IL USA Chinese Academy of Sciences, Shanghai Institutes for Biological Sciences, Institute of Neurosciences, Laboratory of Sensory System, Shanghai 200031, PR China. xu.zhang@ion.ac.cn College of Life Science, Northeast Agricultural University, Harbin 150030, China. zhangxu860328@163.com Huazhong University of Science and Technology Department of Stomatology, Shanghai Tenth People`s Hospital, Tongji University, Shanghai, China Basic Nursing Department School of Nursing Jilin University Changchun China ArQule, Inc., 19 Presidential Way, Woburn, Massachusetts 01801, USA Tianjin Key Laboratory of Metabolic Diseases, Department of Physiology and Pathophysiology, The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Tianjin Medical University , 22 Qixiangtai Road, Heping District, Tianjin 300070 , China Department of Urology Chinese People's Liberation Army (PLA) General Hospital/PLA Medical School Beijing China From the Departments of Thoracic Oncology, Pathology, and Radiation Oncology, State Key Laboratory of Oncology in South China, Cancer Center, Lung Cancer Research Center; and Reproductive Research Center, the Second Affiliated Hospital, Sun Yat-sen University, Guangzhou; and Institute of Intelligence Machine, Chinese Academy of Sciences, Hefei, People's Republic of China. State Key Laboratory of Protein and Plant Gene Research, College of Life Sciences, Peking University, Beijing 100871, People’s Republic of China School of Life Science and Technology, ShanghaiTech University , Shanghai 201210 , China; Shanghai Advanced Research Institute, Chinese Academy of Sciences , Shanghai 201210 , China; Guangdong Institute of Intelligence Science and Technology , Hengqin, Zhuhai 519031 , China Department of Ultrasound, Peking University Third Hospital, Beijing 100191, P. R. China; Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, School of Medicine, Northwest University, Xi’an 710069, P. R. China; CAS Key Laboratory for Biomedical Effects of Nanomaterials & Nanosafety and CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, University of Chinese Academy of Sciences, Beijing 100190, P. R. China The State Key Laboratory of Oncology in Southern China, Guangzhou 510060, China. State Key Laboratory of Oncology in South China Sun Yat‐sen University Guangzhou Guangdong China; Department of Nuclear Medicine Sun Yat‐sen University Cancer Center Guangzhou Guangdong China; Collaborative Innovation Center for Cancer Medicine Sun Yat‐sen University Cancer Center Guangzhou Guangdong China Gansu Key Laboratory of Polymer Materials, College of Chemistry and Chemical Engineering Northwest Normal University, Lanzhou 730070, People's Republic of China State Key Laboratory of Coal Combustion, Huazhong University of Science and Technology, Wuhan 430074, China State Key Laboratory of Bioactive Substance and Function of Natural Medicines; Institute of Materia Medica; Chinese Academy of Medical Sciences and Peking Union Medical College; Beijing 100050; People’s Republic of China Beijing Key Lab of Microstructure and Properties of Solids Faculty of Materials and Manufacturing Beijing University of Technology Beijing 100124 P. R. China Department of Trauma Neurosurgery, Xuzhou Children's Hospital, Xuzhou Medical University, Xuzhou, Jiangsu 221006, P.R. China Department of Dermatology, XiangYa Hospital, Central South University, Changsha, China Department of Urology, Chinese PLA General Hospital/Chinese PLA Medical School, Beijing, China (mainland) Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University School of Environmental Science and Engineering, Shandong University, Ji'nan 250100, China Key Laboratory of Zoological Systematics and Evolution Institute of Zoology Chinese Academy of Sciences Beijing From the Translational Neuroscience Center (X.Z., J.K., T.I., M.M., G.M., Y. Nakamura), Graduate School of Medicine, International University of Health and Welfare, Okawa; School of Pharmacy at Fukuoka (J.K., T.I., Y. Nakamura), International University of Health and Welfare, Okawa; Department of Neurology (J.K., Y. Nakamura), Brain and Nerve Center, Fukuoka Central Hospital, International University of Health and Welfare, Fukuoka; Department of Neurology (H.O., T.F., R.Y., N.I.), Neurological... College of Science; China Agricultural University; Beijing China Chinese Academy of Sciences, Institute of Biophysics, Beijing, China Biochip Center, General Hospital of Ningxia Medical University, Yinchuan 750000, China. Department of Ophthalmology, Shanghai Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200021, China. Department of Stomatology Wuchang Hospital Wuhan City China Department of Urology, the Third Medical Center, Chinese PLA General Hospital, Beijing, China. xzhang@tjh.tjmu.edu.cn. West China School of Pharmacy, Sichuan University, Chengdu 610041, China Center of Clinical and Translational Sciences and Department of Internal Medicine, The University of Texas Health Science Center at Houston, Houston, TX, USA. Xu.Zhang@uth.tmc.edu. 2Center for Clinical and Transitional Sciences, University of Texas Health Science Center, Houston, TX Medical Isotopes Research Center and Department of Radiation Medicine School of Basic Medical Sciences Peking University Beijing 100191 P. R. China Faulty of Medical Technology, Shaanxi University of Chinese Medicine, Xianyang, China Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457, Zhongshan Road, Dalian, 116023, China; Graduate School of the Chinese Academy of Sciences, Beijing, China Shanghai Center for Systems Biomedicine, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China Department of Nutrition and Food Hygiene, School of Public Health, Medical College of Soochow University, Suzhou, China Department of Urology, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China Department of stomatology The Fourth Hospital of Harbin Medical University Harbin China Key Laboratory of Zoonosis Research, Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun 130062, China Hebei Province Key Laboratory of Occupational Health and Safety for Coal Industry, School of Public Health, North China University of Science and Technology, Tangshan, Hebei, P.R. China; Department of Neurosurgery, Changhai Hospital, Naval Medical University, Shanghai 200433, P.R. China State Key Laboratory of Hybrid Rice, Rice Research Institute Sichuan Agricultural University Chengdu 611130 China Department of Biomedical Engineering, Duke University, Durham, North Carolina 27708, Unites States Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, Beijing, People’s Republic of China; Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, People’s Republic of China Department of Thoracic Oncology, Sun Yat-Sen University Cancer Center, Guangzhou 510060, Guangdong Province, China; Guangdong Esophageal Cancer Research Institute, Guangzhou 510060, Guangdong Province, China School of Materials Science and Engineering; National Institute for Advanced Materials; Institute of New Energy Material Chemistry; Computational Centre for Molecular Science; Nankai University College of Food Science and Engineering, Northwest A&F University, Yangling 712100, Shaanxi, China College of Science China Agricultural University Beijing P.R. China Department of Oral Medicine, School of Stomatology, Ninth People's Hospital, Shanghai Jiao Tong University, Shanghai 200011, China. Department of Neuroscience, Karolinska Institute, Stockholm, Sweden Engineering Research Center for Waste Oil Recovery Technology and Equipment, Ministry of Education, Chongqing Technology and Business University, Chongqing 400067, China; Jiangsu Provincial Key Lab for the Chemistry and Utilization of Agro-Forest Biomass, College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, China; Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, Nanjing Forestry University, Nanjing 210037, China Department of Urology/State Key Laboratory of Kidney Diseases, Chinese PLA General Hospital, Beijing, People's Republic of China. Department of Biochemistry , Microbiology and Immunology, Faculty of Medicine, Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, ON K1H 8M5, Canada; Faculty of Medicine , SIMM-University of Ottawa Joint Research Center in Systems and Personalized Pharmacology, University of Ottawa, Ottawa, ON K1H 8M5, Canada Department of Radiation Oncology Shengjing Hospital of China Medial University Shenyang 110022 China Wuchang Hospital Affiliated to Wuhan University of Science and Technology (Stomatology), No. 116 Yangyuan Street, Wuchang District, Wuhan 430063, Hubei, China School of Nursing Jilin University Jilin People's Republic of China Department of Physics and Astronomy, California State University, Northridge, CA 91330-8268 Department of Urology Chinese PLA General Hospital/Chinese PLA Medical Academy Haiding district Beijing P. R. China State Key Laboratory of Luminescent Materials and Devices, South China University of Technology, Guangzhou 510640, China Center for Biostatistics and Bioinformatics, University of Mississippi Medical Center, Jackson, MS. Affiliated Eye Hospital of Nanchang University, Jiangxi Research Institute of Ophthalmology and Visual Science, Jiangxi Provincial Key Laboratory for Ophthalmology, Nanchang, Jiangxi, China CAS Key Laboratory of SSAC Department of biotechnology Dalian Institute of Chemical Physics Chinese Academy of Sciences Dalian 116023 P. R. China Department of Microsurgery, The Second Hospital of Qinhuangdao, Changli, Qinhuangdao, China State Key Laboratory of Drug Research Wuhan Center for Magnetic Resonance, State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan, 430071, P. R. China Department of Urology The First Affiliated Hospital of Nanjing Medical University Nanjing China Key Laboratory of Rubber‐plastics Ministry of Education School of Polymer Science and Engineering Qingdao University of Science and Technology Address: Zhengzhou Rd. 53 Qingdao CN‐266042 China Department of Urology, The Affiliated Nanping First Hospital of Fujian Medical University, Nanping, Fujian, China Department of Chemistry, Rutgers, The State University of New Jersey, Newark, NJ 07102, USA Computer and Information Science and Engineering, University of Florida Gainesville, FL 32611, USA Department of Epidemiology and Biostatistics School of Public Health Anhui Medical University Hefei Anhui China State Key Laboratory of Clean Energy Utilization, Institute for Thermal Power Engineering, College of Energy Engineering, Zhejiang University, Hangzhou 310027, Zhejiang, China Department of Biochemistry, Microbiology and Immunology, Ottawa Institute of Systems Biology, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada College of Food Science and Technology Shanghai Ocean University Shanghai China; Laboratory of Quality and Safety Risk Assessment for Aquatic Products on Storage and Preservation (Shanghai) Ministry of Agriculture Shanghai China Department of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, WI 53226; Department of Oral and Craniofacial Biological Sciences, University of Maryland, Baltimore, MD 21201; and Institute of Neuroscience, Shanghai Institute of Life Sciences, Chinese Academy of Sciences, Shanghai 200031, China Key Laboratory of Zoonosis Research Ministry of Education College of Veterinary Medicine Jilin University 5333 Xian Road Changchun Jilin 130062 China Department of Endocrinology, Shandong Provincial Hospital, Shandong University, No. 324, Jing 5 Road, Jinan, Shandong 250021, China; Shandong Clinical Medical Center of Endocrinology and Metabolism, No. 324, Jing 5 Road, Jinan, Shandong 250021, China; Institute of Endocrinology and Metabolism, Shandong Academy of Clinical Medicine, No. 324, Jing 5 Road, Jinan, Shandong 250021, China Department of Molecular Biology and Diagnostics School of Medicine, Jiangsu University Zhenjiang Jiangsu 212013 China; Jiangsu Key Laboratory of Medical Science and Laboratory Medicine Zhenjiang Jiangsu China Institute for Materials Chemistry and Engineering, Graduate School of Engineering Sciences, and Art, Science and Technology Center for Cooperative Research, Kyushu University, Kasuga 816-8580, Japan, and Department of Chemistry, Harbin Normal University, Harbin 150080, Heilongjiang, People's Republic of China Department of Biomedical Engineering Duke University Durham NC 27708 USA School of Medical Science and Laboratory Medicine, Jiangsu University, 301 Xuefu Road, Zhenjiang, Jiangsu 212013, P R China Institute of Optoelectronic Technology, Fuzhou University, Fuzhou 350116, P. R. China Department of Physics and Astronomy, California State University Northridge, Northridge, California 91330, United States Key Laboratory of Tropical Disease Control of Ministry of Education, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China Anhui Province Key Laboratory of FarmLand Ecological Conservation and Pollution Prevention, School of Resources and Environment, Anhui Agricultural University, Hefei 230036, China Department of Microbiology and Immunology and CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences and Medical Center, University of Science & Technology of China, Hefei, Anhui, China Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of China Department of Endodontics; School and Hospital of Stomatology; Tianjin Medical University; Tianjin 300070; P.R. China Jiangsu Key Laboratory of Medical Science and Laboratory Medicine, Department of Clinical Laboratory, School of Medicine, Jiangsu University, Zhenjiang 212000, China Department of Gynecology and Obstetrics; The Third Affiliated Hospital of Sun Yat-sen University; Guangzhou 510630; China School of Bioscience and Bioengineering, South China University of Technology, Guangzhou, Guangdong 510641, China and BGI Diagnosis, Tianjin, Tianjin 300308, China. Department of Urology, Chinese People's Liberation Army General Hospital, Military Postgraduate Medical College, Beijing, People's Republic of China Engineering Research Center for Medicine, College of Pharmacy, Harbin University of Commerce, Harbin 150076, Heilongjiang, China. Dalian Institute of Chemical Physics, Chinese Academy of Sciences Dalian China School of Medical Science and Laboratory Medicine, Jiangsu University, Zhenjiang, Jiangsu, People's Republic of China. Department of Chemistry and Key Laboratory of Organic Synthesis of Jiangsu Province, Soochow University, Suzhou 215123, P. R. China Department of Physics and Astronomy California State University Northridge CA 91330 USA Division of Cardiology, Department of Geriatrics The First Affiliated Hospital of Chongqing Medical University No. 1 Yixueyuan Road Yuzhong District, Chongqing 400016 China; Laboratory Research Center The First Affiliated Hospital of Chongqing Medical University Chongqing 400016 China Department of Oral and Maxillofacial‐Head and Neck Oncology, Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai China; Shanghai Key Laboratory of Stomatology Shanghai Research Institute of Stomatology Shanghai China; National Clinical Research Center for Oral Disease Shanghai China Department of Epidemiology Center for Global Health School of Public Health Nanjing Medical University Nanjing Jiangsu 211166 P. R. China College of Basic Medicine and School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210029, China Graduate School of Xuzhou Medical University Xuzhou China; Department of Orthopedics The Second Affiliated Hospital of Xuzhou Medical University Xuzhou China Jiangsu Provincial Key Laboratory of Advanced Photonic and Electronic Materials, School of Electronic Science and Engineering, Nanjing University, Nanjing 210093, P. R. China Modern Research Center for Traditional Chinese Medicine; Beijing University of Chinese Medicine; Beijing 100029 China College of Aerospace Engineering, Chongqing University, Chongqing 400044, China Jiangsu Key Laboratory of Medical Science and Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang, P. R. China Hefei Jingchuang Technology Co., Ltd, Hefei, 231500, P. R. China Section of Hematology‐Oncology Department of Medicine Comprehensive Sickle Cell Center University of Illinois at Chicago Chicago IL USA Harvard John A. Paulson School of Engineering and Applied Science Harvard University Cambridge MA 02138 USA Laboratory of Electron Microscopy, Ultrastructural Pathology Center Peking University First Hospital Beijing China Division of Cardiology, Department of Geriatrics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People’s Republic of China and Laboratory Research Center, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People’s Republic of China HLA Laboratory, Liaoning Blood Center Shenyang Liaoning China; Key Laboratory of Blood Safety Research of Liaoning Shenyang Liaoning China Department of Dermatology, Center for Infectious Skin Diseases, No.1 Hospital of Wuhan, Wuhan, China; Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical University, Tianjin, China College of Chemistry and Pharmaceutical Engineering; Nanyang Normal University; Nanyang; P. R. China Departments of Molecular Medicine and Neuroscience, and Neuroscience Translational Center, The Scripps Research Institute, La Jolla, CA 92037, USA.; Neurodegenerative Disease Center, Scintillon Institute, San Diego, CA 92121, USA. Collaborative Innovation Center for Cancer Medicine, State Key Laboratory of Oncology in South China, Guangdong Esophageal Cancer Institute, Cancer Center, Sun Yat-Sen University, Guangzhou, China Department of Otolaryngology Head and Neck Surgery, Beijing TongRen Hospital Capital Medical University Beijing China; Beijing Key Laboratory of Nasal diseases Beijing Institute of Otolaryngology Beijing China; Department of Allergy, Beijing TongRen Hospital Capital Medical University Beijing China; Research Unit of Diagnosis and Treatment of Chronic Nasal Diseases, Chinese Academy of Medical Sciences Beijing China Institute of Human Virology Department of Pathogen Biology and Biosecurity Key Laboratory of Tropical Disease Control of Ministry of Education Zhongshan School of Medicine Sun Yat‐sen University Guangzhou 510080 China CAS Key Laboratory of Plant Germplasm Enhancement and Specialty Agriculture, The Chinese Academy of Sciences Wuhan Botanical Garden Wuhan 430074 China; Center of Conservation Biology, Core Botanical Gardens The Chinese Academy of Sciences Wuhan 430074 China Department of Urology Military Postgraduate Medical College Chinese People's Liberation Army General Hospital Beijing China School and Hospital of Stomatology, Tianjin Medical University, Tianjin 300070, People’s Republic of China Mary Ann Gilligan, Joan Neuner, and Ann B. Nattinger are with the Department of Medicine and Health Policy Institute, Medical College of Wisconsin, Milwaukee. At the time of the study, Xu Zhang was with the Division of Biostatistics, Medical College of Wisconsin, Milwaukee. Rodney Sparapani and Purushottam W. Laud are with the Division of Biostatistics, Medical College of Wisconsin, Milwaukee. Department of Animal Nutrition and Feeding Technology, Hunan Institute of Animal Science and Veterinary Medicine, Changsha, P.R. China and Department of Pathology, School of Basic Medicine, Lanzhou University, Lanzhou, China State Key Laboratory of Bioactive Substance and Function of Natural Medicines; Peking Union Medical College; Institute of Materia Medica; Chinese Academy of Medical Sciences; Beijing 100050 College of Life and Environmental Science; Wenzhou University; Wenzhou 325035; China School of Flexible Electronics (Future Technologies) Institute of Advanced Materials Jiangsu National Synergetic Innovation Center for Advanced Materials Nanjing Tech University Nanjing 211816 China School of Nursing, Jilin University, Jilin, People's Republic of China Department of Urology, the third Medical Centre, Chinese PLA General Hospital State Key Laboratory of Silicate Materials for Architectures; School of Chemistry; Chemical Engineering and Life Science Wuhan University of Technology; Wuhan 430070; China School of Mathematics and Statistics, Southwest University, Chongqing, China Central Laboratory, Xuanwu Hospital, Capital Medical University, Key Laboratory for Neurodegenerative Disease of the Ministry of Education, Beijing, China Key Laboratory for the Green Preparation and Application of Functional Materials, Ministry of Education, Hubei Key Laboratory of Polymer Materials, Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials, Faculty of Materials Science and Engineering, Hubei University, Wuhan 430062, PR China Department of Urology, People's Liberation Army General Hospital, Beijing, China Department of Orthopedics, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai 201300, China Department of Neurosurgery Changzheng Hospital Naval Medical University Shanghai China State Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases, Med-X Center for Materials, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China All authors: Institute of Food Crops, Jiangsu Academy of Agricultural Sciences/Jiangsu Collaborative Innovation Center for Modern Crop Production, Nanjing, China; and fourth author: Institute of Biotechnology and Genetic Engineering, The University of Agriculture, Peshawar, Pakistan. State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, College of Plant Protection, Yunnan Agricultural University , Kunming 650201 , China Department of Neurology Neurological Institute Graduate School of Medical Sciences Kyushu University Fukuoka Japan School of Biomedical Engineering , , Beijing 100069, China; Capital Medical University , , Beijing 100069, China; Beijing Advanced Innovation Center for Big Data-Based Precision Medicine , , Beijing 100069, China; Capital Medical University , , Beijing 100069, China; Beijing Key Laboratory of Fundamental Research on Biomechanics in Clinical Application , , Beijing 100069, China; Capital Medical University , , Beijing 100069, China Center for Biostatistics and Bioinformatics, University of Mississippi Medical Center, Jackson, MS.; Department of Internal Medicine, University of Texas Health Science Center at Houston, Houston, TX. CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology (NCNST) Beijing 100190 P. R. China; University of Chinese Academy of Sciences Beijing 100049 P. R. China; Bioinformatics Division and Center for Synthetic and Systems Biology TNLIST Department of Automation Tsinghua University Beijing 100084 P. R. China Department of Gastroenterology and Hepatology The Second Affiliated Hospital of Harbin Medical University Harbin 150001 China 1Shenzhen Key Laboratory of Reproductive Immunology for Peri-implantationShenzhen Zhongshan Institute for Reproductive Medicine and Genetics, Fertility Center, Shenzhen Zhongshan Urology Hospital, Shenzhen, China Department of Chinese Medicine, Huadong Hospital Affiliated to Fudan University, Shanghai, P.R. China Laboratory for Microbial Resources, School of Ecology and Environment, Inner Mongolia University, Hohhot, 010021, PR China Department of Urology, China PLA General Hospital, Beijing, China. CAS Key Laboratory of Plant Germplasm Enhancement and Specialty Agriculture, Chinese Academy of Sciences, Wuhan Botanical Garden, Wuhan 430074, People's Republic of China Institute of Neuroscience and State Key Laboratory of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, China Ottawa Institute of Systems Biology and Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, K1N 6N5, Canada Verschuren Centre for Sustainability in Energy & the Environment; Cape Breton University; Sydney; Canada Key Laboratory of Synthetic and Biological Colloids, Ministry of Education, School of Chemical and Material Engineering, Jiangnan University, Wuxi, Jiangsu 214122, P. R. China National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, P.R. China Geo-Energy Research Institute, College of Electromechanical Engineering, Qingdao University of Science and Technology, Qingdao 266061, China Institute of Biological Sciences, Jinzhou Medical University, Jinzhou, Liaoning, China; Microbiological Laboratory, Center for Disease Control and Prevention of Jinzhou, Jinzhou, Liaoning, China The State Key Lab of Reproductive, Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China Cancer Center Faculty of Health Sciences University of Macau Macau 999078 China; Center for Precision Medicine Research and Training Faculty of Health Sciences University of Macau Macau 999078 China Center for Clinical and Translational Sciences, McGovern Medical School at The University of Texas Health Science Center at Houston, Houston Wuhan Natural Resources Conservation and Utilization Center, Wuhan 430014, China School of Materials Science and Engineering, Nankai University, Tianjin 300350, China Department of Hand Surgery, The Third Hospital of Hebei Medical University, NO.139 Ziqiang Road, Shijiazhuang 050051, Hebei, People's Republic of China. State Key Laboratory of High-efficiency Utilization of Coal and Green Chemical Engineering; School of Chemistry and Chemical Engineering; Ningxia University; Yinchuan; China Department of Urology, PLA General Hospital, Military Postgraduate Medical College, Beijing, China. Theoretical and Applied Mechanics Program, Northwestern University, Evanston, IL 60208 Radiotherapy Department, Cancer Hospital of China Medical University, Shenyang, Liaoning 110042, P.R. China Department of Gastroenterology and Hepatology, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China (mainland) Department of Nursing, Women and Children's Hospital, School of Medicine, Xiamen University, Xiamen, Fujian, China Ningxia Medical University, Yinchuan, Ningxia, China Jiangsu Provincial Key Laboratory of Advanced Photonic and Electronic Materials School of Electronic Science and Engineering Collaborative Innovation Center of Advanced Microstructures Nanjing University Nanjing 210093 China Department of Neurology Neurological Institute Graduate School of Medical Sciences Kyushu University Fukuoka Japan; Department of Neurology and Tianjin Neurological Institute Tianjin Medical University General Hospital Tianjin China Center for Cancer Research, 1Thoracic and GI Malignancies Branch, Center for Cancer Research, NCI, NIH, Bethesda, Maryland. Engineering Research Centre of Oil Shale Comprehensive Utilization, Ministry of Education, Northeast Electric Power University, Jilin City, Jilin 132012, PR China Yantai Academy of Agricultural Sciences , Gangcheng West Street, Fushan District, Yantai City, Yantai 264025 , China Key Laboratory of Laboratory Medicine of Jiangsu Province, Medical School Jiangsu University, Zhenjiang, Jiangsu, People's Republic of China College of Life and Environmental Science, Wenzhou University, Wenzhou 325035, China State Key Laboratory of Oncology in South China, Guangzhou, Guangdong, 510060, P. R. China. zsyzhangxu@163.com Obstetrics and Gynecology Department, Suzhou Ninth People's Hospital of Soochow University, Suzhou, China Verschuren Centre for Sustainability in Energy and the Environment; Cape Breton University; Sydney, Canada Department of Chemistry and Department of Biology, University of Waterloo, Ontario, N2L 3G1, Canada, and Department of Chemistry, University of Science and Technology of China, Hefei, 230026, China Ottawa Institute of Systems Biology and Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine University of Ottawa 451 Smyth Road Ottawa ON KIH 8M5 Canada Center for Clinical and Translational Sciences, University of Texas Health Science Center, Houston, TX School of Life Sciences Tsinghua University Beijing 100084 China Institute of Chemistry, the Chinese Academy of Sciences (CAS), Beijing 100190, China; Beijing National Laboratory for Molecular Sciences, Beijing 100190, China; Graduate School of the Chinese Academy of Sciences, Beijing 100190, China Provincial Key Lab for Agrobiology, Jiangsu Academy of Agricultural Sciences/Jiangsu Collaborative Innovation Center for Modern Crop Production, 50 Zhongling Street, Nanjing, Jiangsu 210014, China College of Life Sciences, Nankai University, Tianjin, China Key Lab of Ministry of Education for Protection and Utilization of Special Biological Resources in Western China Ningxia University Ningxia China; School of Life Science Ningxia University Ningxia China Department of Urology, PLA General Hospital Sun Yat‐sen University Cancer Center State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Guangzhou China; Department of Thoracic Oncology Sun Yat‐Sen University Cancer Center Guangzhou China; Guangdong Esophageal Cancer Research Institute Guangzhou China Hand Surgery Department, The Second Hospital of Qinhuangdao, Changli, Qinhuangdao, Hebei, China Jiangsu Key Laboratory of Medical Science and Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu, People's Republic of China Center for Reproductive Medicine, Women and Children’s Hospital of Chongqing Medical University , China Department of Biophysics and Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Key Laboratory of Advanced Energy Materials Chemistry (Ministry of Education); Computational Centre for Molecular Science; Institute of New Energy Material Chemistry; Collaborative Innovation Center of Chemical Science and Engineering (Tianjin); School of Materials Science and Engineering CAS Key Laboratory for Biological Effects of Nanomaterials & Nanosafety, National Center for Nanoscience and Technology, 11 Beiyitiao, Zhongguancun, Beijing 100190, China Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China Engineering Center of Cellular Immunotherapy of Guizhou Province, Guizhou Medical University, Guiyang, China; Guizhou Provincial Key Laboratory of Pharmaceutics, Guiyang, China; School of Pharmaceutical Sciences, Guizhou Medical University, Guizhou, China; State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, China 1 State Key Laboratory of Neuroscience, Institute of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China Department of Urology, State Key Laboratory of Kidney Diseases, Chinese People's Liberation Army General Hospital, PLA Medical School, Beijing, People's Republic of China Department of Cardiology, Tianjin key laboratory of Ionic-Molecular Function of Cardiovascular Disease, Tianjin Institute of Cardiology, The Second Hospital of Tianjin Medical University, Tianjin, China 4Department of Urology, State Key Laboratory of Kidney Diseases, Chinese PLA General Hospital, Chinese PLA Medical Academy, Beijing, China. Department of Endocrinology and Metabolism, Shandong Provincial Hospital affiliated to Shandong University, Jinan, Shandong, China Central South University of Forestry and Technology, Changsha, China. Department of Nephrology The First People's Hospital of Taixing District Taizhou China Yangtze University Comprehensive Sickle Cell Center, Section of Hematology/Oncology, Department of Medicine, University of Illinois at Chicago Chicago Illinois School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts 02138, United States Key Laboratory for Plant Diversity and Biogeography of East Asia, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, China;; University of Chinese Academy of Sciences, Beijing, China;; Key Laboratory of Plant Germplasm Enhancement and Specialty Agriculture, Wuhan Botanical Garden, Chinese Academy of Sciences, Wuhan, China; Department of Microbiology and Immunology, Weill Cornell Medical College College of New Energy, China University of Petroleum (East China), 266580, Qingdao, China; College of Chemistry and Chemical Engineering, China University of Petroleum (East China), 266580, Qingdao, China College of Materials Science and Engineering, Nanjing Tech University, 30 South Puzhu Road, Nanjing 211816, PR. China; Jiangsu Collaborative Innovation Centre for Advanced Inorganic Function Composites, Nanjing Tech University, Nanjing 211816, PR. China Department of Endocrinology, Shandong Provincial Hospital, Cheeloo College of Medicine Shandong University Jinan China; Shandong Provincial Key Laboratory of Endocrinology and Lipid Metabolism, Institute of Endocrinology and Metabolism Shandong Academy of Clinical Medicine Jinan China; Shandong Clinical Medical Center of Endocrinology and Metabolism Jinan China Transfusion Medicine Institute, Liaoning Blood Center Shenyang China; Liaoning Provincial Key Laboratory for Blood Safety Research Shenyang China Department of Medicine, Hematology/Oncology University of Illinois at Chicago Chicago IL USA Department of Automation, Xiamen University , Xiamen 361005, China Department of Medical Laboratory Technology, College of Medical Technology, Shaanxi University of Chinese Medicine, Xianyang 712046, China. Tianjin Key Laboratory of Metabolic Diseases and Department of Physiology Tianjin Medical University Tianjin China School of Public Health, University of Texas, Houston, TX Department of Epidemiology School of Public Health Nanjing Medical University Nanjing China; Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment Collaborative Innovation Center of Cancer Medicine Nanjing Medical University Nanjing China School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China; Shanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai 201210, China Department of Medical Laboratory; College of Laboratory Medicine, Dalian Medical University; Dalian Liaoning Province China Hong Yang, Hui Liu, Xu Zhang, Qun Li, Ting Lin, Mengzhong Liu, and Jianhua Fu, Sun Yat-sen University Cancer Center, Guangzhou; Yuping Chen, Zhijian Chen, and Geng Wang, Cancer Hospital of Shantou University Medical College, Shantou; Zhijian Chen, The University of Hong Kong-Shenzhen Hospital, Shenzhen, Guangdong Province; Chengchu Zhu, Haihua Yang, Baofu Chen, and Min Kong, Taizhou Hospital, Wenzhou Medical University, Linhai; Weimin Mao and Xiao Zheng, Zhejiang Cancer Hospital, Hangzhou, Zhejiang... Department of Urology Chinese PLA General Hospital Beijing China State Key Laboratory of Silicate Materials for Architectures; and School of Chemistry; Chemical Engineering and Life Science; Wuhan University of Technology; Wuhan; P. R. China The First Affiliated Hospital of Wenzhou Medical College, Wenzhou, China. School of Nursing, Liaoning University of Traditional Chinese Medicine, Shenyang, China. Department of Endocrinology and Metabolism (M.Z., Q.G., S.S., Xu.Z., Y.S., H.Z., L.F., C.Y., Q.L., Xi.Z., C.X., J.Z.), Jinan, 250012 Shandong, China;; Shandong Provincial Hospital affiliated to Shandong University, Institute of Endocrinology and Metabolic Diseases (M.Z., Q.G., S.S., Xu.Z., Y.S., H.Z., L.F., C.Y., Q.L., Xi.Z., L.G., C.X., J.Z.), Jinan, 250012 Shandong, China; Center for Clinical and Translational Sciences, University of Texas Health Science Center at Houston, Houston, TX, USA Beijing University of Chinese Medicine Center for Design and Manufacturing Excellence, The Ohio State University, Columbus, OH, USA Department of Neuroscience, Karolinska Institute, S-171 77, Stockholm, Sweden; Departments of Aerospace Physiology and Neurobiology, Fourth Military Medical University, Xian, 710032, People’s Republic of China; and Gastroenteric Biology Center (CURE), Los Angeles, CA Dalian National Laboratory for Clean Energy iChEM Dalian Institute of Chemical Physics Chinese Academy of Sciences Dalian 116023 China Clinical College of Ningxia Medical University, Beijing National Biochip Research Center Sub-center in Ningxia, General Hospital of Ningxia Medical University, Yinchuan 750004, China. Alberta Centre for Toxicology, Calgary, Alberta, Canada State Key Laboratory of Oral Diseases, National Clinical Research Centre for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China Department of Orthopedics, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai 201399, China; Department of Gerontology The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital Jinan China Key Laboratory of Human Disease Comparative Medicine, National Health Commission of China (NHC) Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences, Peking Union Medicine College Beijing China; National Human Diseases Animal Model Resource Center and Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases Institute of Laboratory Animal Science, Peking Union Medicine College, Chinese Academy of Medical Sciences Beijing China Engineering Research Center of Advanced Functional Material Manufacturing of Ministry of Education School of Chemical Engineering Zhengzhou University Zhengzhou 450001 China Department of Urology People's Liberation Army General Hospital Beijing China Key Laboratory of Metabolic Cardiovascular Disease, Tianjin Medical University, Tianjin 300070, China. xuzhang@tmu.edu.cn. Liaoning Blood Center Transfusion Medicine Institute Shenyang China; Liaoning Provincial Key Laboratory for Blood Safety Research Shenyang China; Key Laboratory of Blood Safety Research of Shenyang Shenyang China Institute of Human Virology, Key Laboratory of Tropical Disease Control of Ministry of Education, Guangdong Engineering Research Center for Antimicrobial Agent and Immunotechnology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China Department of Urology, The Third Medical Centre of PLA General Hospital, Beijing, China. School of Medicine and Life Sciences, Nanjing University of Chinese Medicine, Nanjing 210023, P.R. China Institute of Pesticide of School of Chemistry and Chemical Engineering and School of Horticulture and Plant Protection, Yangzhou University, Yangzhou, Jiangsu 225002, PR China Center of Biostatistics and Bioinformatics, University of Mississippi Medical Center, Jackson, MS, USA Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, China; Shandong Clinical Medical Center of Endocrinology and Metabolism, Jinan, Shandong, China; Institute of Endocrinology and Metabolism, Shandong Academy of Clinical Medicine, Jinan, Shandong, China Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, United States; School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts 02138, United States Department of Chemistry, and Department of Biology, University of Waterloo, Ontario, N2L 3G1, Canada Department of Nephrology, Taixing People’s Hospital, Taizhou, Jiangsu, China State Key Laboratory of Microbial Metabolism, School of Life Science and Biotechnology, Shanghai Jiaotong University Department of Neurosurgery, Changzheng Hospital, Naval Medical University, Neurosurgical Institute of Shanghai, Neurosurgical Institute of PLA, Shanghai, China Laboratory of Electron Microscopy, Pathology Center, Peking University First Hospital, Beijing, 100034, China R&D Center, Lifetech Scientific (Shenzhen) Co., Ltd. , Shenzhen 518057, China; R&D Center, Lifevalve Medical Scientific Co., Ltd. , Shenzhen 518057, China Institute for Tissue Engineering and Regenerative Medicine, The Chinese University of Hong Kong, Hong Kong, China.; School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China. Dalian Institute of Chemical Physics Chinese Academy of Sciences 457, Zhongshan Road Dalian 116023 China Key Laboratory of Information Photonics Technology; Key Laboratory of Photoelectronic Imaging Technology and System State Key Laboratory of Military Stomatology and National Clinical Research Center for Oral Diseases and Shanxi Clinical Research Center for Oral Diseases, Department of Orthodontics, School of Stomatology, The Fourth Military Medical University, Xi’an, Shaanxi 710032, China Cancer Centre Faculty of Health Sciences University of Macau Macau SAR 999078 China; Institute of Translational Medicine Faculty of Health Sciences University of Macau Macau SAR 999078 China National Key Laboratory of Agricultural Microbiology, College of Life Science and Technology, Huazhong Agricultural University, Wuhan 430070, China School of Nursing, Peking University, Beijing, China. CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Beijing 100190, People’s Republic of China Department of Gastroenterology, Zhongshan Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China Liaoning Blood Center, Shenyang, Liaoning 110044, P.R. China. Email: ljp_63@163.com. Center of Synthetic and Systems Biology, School of Life Sciences, Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing 100084, China Institut des Sciences Chimiques de Rennes; ISCR-UMR CNRS 6226; 35042 Rennes Cedex; France; Institut National des Sciences Appliquées Department of Endocrinology and Metabolism, Shandong Provincial Hospital affiliated to Shandong University, Jinan; Institute of Endocrinology and Metabolic Diseases, Shandong Academy of Clinical Medicine, Jinan, Shandong, China.. |
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