http://rdf.ncbi.nlm.nih.gov/pubchem/author/MD5_53199e489c214713ea041248e95280e2
Outgoing Links
| Predicate | Object |
|---|---|
| family-name | Chen Yan Chen |
| name | Yan Chen |
| given-name | Yan |
| organization-name | Department of Endocrinology, The Second Hospital of Jilin University, Changchun, China Department of Hematology, Xiangya Hospital, Central South University, Changsha, China. yanchenangel@163.com MOE Key Laboratoryof Cell Activities and Stress Adaptations, School of Life Sciences Lanzhou University Lanzhou 730000 China Jiangsu Key Laboratory of Carcinogenesis and Intervention, China Pharmaceutical University, Nanjing 210009, People's Republic of China Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, P. R. China Clinical Metabolomics Center School of Traditional Chinese Pharmacy China Pharmaceutical University Nanjing 211198 China School of Pharmacy, Fudan University, Shanghai 201203, China Department of Cardiology, Fuwai Hospital Chinese Academy of Medical Sciences Beijing China Contribution from the Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, and Novartis Forschungsinstitut, Brunner Strasse 59, A-1235, Vienna, Austria 1State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu, P.R. China. Department of Dermatology, Ningbo Medical Center Lihuili Hospital, Ningbo City, Zhejiang Province 315040, China. State Key Laboratory of Precision Measuring Technology & Instruments, Tianjin University, Tianjin 300072, China; College of Precision Instrument and Optoelectronics Engineering, Tianjin University, Tianjin 300072, China Laboratory of Transfusion, Jiangsu Province Blood Center, Nanjing 210042, Jiangsu Province, China. Nephrology Department, The Affiliated Hospital of Jiangnan University, 214000, China Hainan Center for Disease Control & Prevention Haikou Hainan China Department of Clinical Laboratory, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, Fujian 350014, P.R. China Joint Laboratory of Reproductive Medicine, Sichuan University-The Chinese University of Hong Kong, Chengdu 610041, China; Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu 610041, China Division of Pharmacy Practice and Administrative Sciences, James L Winkle College of Pharmacy, University of Cincinnati Academic Health Center, Cincinnati, OH Ecological Security and Protection Key Laboratory of Sichuan Province, Mianyang Normal University, Mianyang, Sichuan 621000, People's Republic of China Department of Geriatric Medicine, Fujian Provincial Hospital, Fujian Provincial Institute of Clinical Geriatrics, Fujian Provincial Key Laboratory of Geriatric Diseases, Fujian Medical University, Fuzhou, China The First Affiliated Hospital, Collgeg of Medicine, Zhejiang University, Hangzhou 310003, China. Traditional Chinese Medicine College, Ningxia Medical University, Yinchuan 750004, Ningxia Hui Autonomous, China State Key Laboratory of Soil and Sustainable Agriculture, Institute of Soil Science, Chinese Academy of Sciences , Nanjing, China Department of Pharmacy China Pharmaceutical University Nanjing Drum Tower Hospital Nanjing China; School of Basic Medicine and Clinical Pharmacy China Pharmaceutical University Nanjing China Department of Molecular Genetics and Biomolecular Drug Discovery, Oncology, Bristol–Myers Squibb Pharmaceutical Research Institute, P.O. Box 4000, Princeton, NJ 08543; and Molecular Signaling Unit, Laboratory of Cellular Development and Oncology, National Institute of Dental Research, National Institutes of Health, Bethesda, MD 20892 Department of Pediatrics, The Affiliated Hospital of Zunyi Medical University, Guizhou Children's Hospital； Collaborative Innovation Center for Tissue Injury Repair and Regenerative Medicine of Zunyi Medical University， Zunyi 563000， Guizhou Province, China,E-mail：cyz600@163.com. School of Resources and Environmental Engineering, Shandong Agriculture and Engineering University, Jinan 250100, China Department of Neurology, Tongji Hospital, Tongji University, Shanghai, 200065, China Translational Medical Sciences, School of Medicine, University of Nottingham, Nottingham, UK State Key Laboratory of Southwestern Chinese Medicine Resources Chengdu China; School of Pharmacy Chengdu University of Traditional Chinese Medicine Chengdu China Department of Pharmacy The First Affiliated Hospital and College of Clinical Medicine of Henan University of Science and Technology Luoyang 471003 China Department of Endocrinology and School of Medicine, Chongqing University Central Hospital, Chongqing Emergency Medical Center, Chongqing 400014, China. Department of Pharmacy Xiang'an Hospital of Xiamen University Xiamen P. R. China Department of Pharmacy, School of Pharmaceutical Sciences, University of Strathclyde, Glasgow G1 1XW Princess Margaret Cancer CentreUniversity Health NetworkTorontoCanada Department of Nephropathy, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, P.R China Department of General Surgery The First Affiliated Hospital of Soochow University Suzhou China Department of Radiology, The First Affiliated Hospital of Sun Yat-sen University, 58 Zhongshan Second Rd, Yuexiu District, Guangzhou, Guangdong, China, 510080. School of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules, Shanghai Jiao Tong University, Shanghai200240, China Department of Oncology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, People’s Republic of China The Second Department of Pediatrics, Affiliated Hospital of Zunyi Medical University , GuiZhou Province, Zunyi, China Taihe Hospital, Hubei Province, China. Hepatobiliary Surgery Institute, Southwest Hospital, Army Medical University, Chongqing 400038, P.R. China Department of Geriatric Medicine, Fujian Provincial Hospital, Fujian Key Laboratory of Geriatrics, Fujian Provincial Center for Geriatrics, Fujian Medical University, Fuzhou 350001, China Department of Outpatient and Emergency Management, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, China State Key Laboratory of Infrared Physics Shanghai Institute of Technical Physics Chinese Academy of Sciences 500 Yu Tian Road Shanghai 200083 China; University of Chinese Academy of Sciences 19 Yuquan Road Beijing 100049 China Department of Clinical Laboratory, Fujian Provincial Cancer Hospital, The Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, China University of Alberta, Calgary, Alberta, Canada School of Life Sciences, Northeast Normal University, Changchun 130024, China; Baicheng Medical College, Baicheng 137000, China Department of Hematology, Lanzhou Military Area of Chinese PLA, Lanzhou, Gansu Province, China. Institute for Integrative Nanosciences, IFW Dresden, Helmholtzstraße 20, 01069, Dresden, Germany 3Molecular and Cellular Developmental Biology Laboratory, Harbin Institute of Technology, Harbin, China Department of Prosthodontics Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration Shandong University Stomatology Hospital Jinan China Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institute for Biological Sciences, Graduate School of the Chinese Academy of Sciences, The Chinese Academy of Sciences, Shanghai, China Innovation Center of Water Security for Water Source Region of Mid-route Project of South-North Water Diversion of Henan Province, Key Laboratory of Ecological Security for Water Source Region of Mid-line of South-to-North Diversion Project of Henan Province, School of Agricultural Engineering, Nanyang Normal University, Nanyang 473061, PR China State Key Laboratory of Precision Electronics Manufacturing Technology and Equipment, Guangdong University of Technology, Guangzhou, China Institute of Quality Standard and Monitoring Technology for Agro-products of Guangdong Academy of Agricultural Sciences and Guangdong Provincial Key Laboratory of Quality & Safety Risk Assessment for Agro-products, Guangzhou 510640, China Bristol-Myers Squibb, Research and Development, Department of Discovery Chemistry, Wallingford, Connecticut, USA Chemical and Engineering Materials Division Oak Ridge National Laboratory Oak Ridge TN 37831 USA Department of Obstetrics and Gynecology, North China University of Science and Technology Affiliated Hospital, Tangshan, Hebei, China College of Pharmaceutical Science Zhejiang University of Technology Hangzhou P. R. China Key Laboratory of Drug Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, P.R. China The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, University of Electronic Science and Technology of China, Chengdu 610054, P. R. China Collaborative innovation center of modern bio-manufacture; Anhui University; Hefei 230601; P. R. China Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China;Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, ASTIP-IAS03, Beijing 100193, China; Department of Pathology, Shanghai Huadong Hospital, Fudan University, Shanghai 200040, China. Institute of Horticultural Biotechnology, Fujian Agriculture and Forestry University , Fuzhou, Fujian 350002 , China Cardiology Division Department of Medicine Queen Mary Hospital University of Hong Kong Hong Kong SAR China; Cardiology Division Department of Medicine University of Hong Kong Shenzhen Hospital Shenzhen China 1International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China; 2Shanghai Key Laboratory of Embryo Original Diseases, Shanghai, China; 3Shanghai Municipal Key Clinical Specialty Project, Shanghai, China Department of Pediatrics, Peking University First Hospital, Beijing, China. Global Health Research Center, Duke Kunshan University, Kunshan, Jiangsu, China 1Department of Cell Biology, New York University School of Medicine, New York, NY 10016 Department of Chemistry, Western Michigan University, Kalamazoo, Michigan 49008 Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences Beijing China Department of General Surgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China Neutron Sciences Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831, United States State Key Laboratory of Food Science and Resources Nanchang University Nanchang China The Second Department of Pediatrics, Affiliated Hospital of Zunyi Medical University , Zunyi, Guizhou , China Department of Radiation Oncology, MD Anderson Cancer Center at Cooper, and Beijing BIT&GY Pharmaceutical R&D Co. Ltd Beijing PR China Department of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha 410017, China Department of Neurology, Huashan Hospital, Fudan University, Shanghai, China Department of Bone and Joint Surgerythe First Affiliated Hospital of Guangxi Medical UniversityNanningGuangxiChina; Department of Orthopedics and TraumatologyThe University of Hong KongHong Kong; Bone Bioengineering LaboratoryDepartment of Biomedical EngineeringColumbia UniversityNew YorkNYUSA Department of Hematology Xiangya Hospital Central South University Changsha China Burning Rock Biotech Guangzhou China Department of General Surgery and Laparoscopic Center, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China. Xiamen Entry-Exit Inspection and Quarantine Bureau, Xiamen 361026, China Engineering Research Center of Clinical Functional Materials and Diagnosis &Treatment Devices of Zhejiang Province, Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou 325000, People’s Republic of China National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun, China.; Key Laboratory for Molecular Enzymology and Engineering, The Ministry of Education, School of Life Sciences, Jilin University, Changchun, China. Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, PR China;; Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing, PR China; Division of Respiratory Disease, Department of Internal Medicine, The Second Xiangya Hospital, Central-South University Department of Nuclear Science and Engineering; Massachusetts Institute of Technology; Cambridge; USA School of Mathematics and Physics North China Electric Power University Beinong Road 2, Changping Beijing 102206 P. R. China; Institute of Clusters and Low Dimensional Nanomaterials North China Electric Power University Beinong Road 2, Changping Beijing 102206 P. R. China; School of New Energy North China Electric Power University Beinong Road 2, Changping Beijing 102206 P. R. China Department of Oncology, Wannan Medical College, Wuhu, Anhui 241000, China Department of Ophthalmology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, China Digestive Endoscopy Center, Changhai Hospital, Shanghai, China; Department of Gastroenterology, Changhai Hospital, Shanghai, China Key Laboratory of Lung Cancer Research of Yunnan Province The Third Affiliated Hospital of Kunming Medical University Kunming 650118 PR China College of Materials Science and Engineering, Fuzhou University, Fuzhou 350108, China Department of Nephrology , , Jiangyin, Jiangsu , China; The Affiliated Jiangyin Hospital of Southeast University Medical College , , Jiangyin, Jiangsu , China School of Mathematics and Physics; North China Electric Power University; Beijing 102206; P. R. China; Institute of Clusters and Low Dimensional Nanomaterials The Second Department of Pediatrics, Affiliated Hospital of Zunyi Medical College, Zunyi 563000, Guizhou Province, China. E-mail: cyz600@163.com. Department of Oncology, Zhongda Hospital, Southeast University, Nanjing 210009, China; School of Medicine, Southeast University, Nanjing 210009, China The Second Department of Pediatrics, Affiliated Hospital of Zunyi Medical University, Zunyi, GuiZhou Province, People’s Republic of China; Department of Pathology, UT Southwestern Medical Center, Dallas, TX, USA School of Ophthalmology and Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China; Key Laboratory of Vision Science, Ministry of Health P.R. China, Wenzhou, Zhejiang, China Joint BioEnergy Institute, Emeryville, California 94608, United States; Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States; Department of Energy Agile BioFoundry, Emeryville, California 94608, United States Institute of Biopharmaceutical Research; Liaocheng University; Liaocheng 252059; P.R. China Department of Hematology, Xiangya Hospital, Central South University, Changsha, Hunan, China Department of Cardiovascular Surgery, Yan’an Hospital of Kunming Medical University, Kunming, Yunnan, China (mainland) Department of Gynecology and Obstetrics The Affiliated Hospital of North Sichuan Medical College Nanchong China Cancer Institute, Third Affiliated Hospital, Kunming Medical University, Tumor Hospital of Yunnan Kunming Province, Kunming, Yunnan 650100, P.R. China State Key Laboratory for Structural Chemistry of Unstable and Stable Species, Beijing National Laboratory for Molecular Sciences (BNLMS), CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China; University of Chinese Academy of Sciences, Beijing 100049, P. R. China Department of Neurology, Shandong Provincial Hospital (Provincial Hospital Affiliated to Shandong First Medical University), Jinan, China Department of Obstetrics and Gynecology, Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325200, P.R. China Beijing Key Laboratory of Environmental Science and Engineering, School of Material Science & Engineering, Beijing Institute of Technology, Beijing 100081, China Institute of Pathogenic Biology, Shandong University School of Medicine, Jinan, Shandong, China School of Chemistry and Chemical Engineering, State Key Laboratory of Metal Matrix Composites, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, People’s Republic of China Shanxi Key Laboratory of Ecological Animal Science and Environmental Veterinary Medicine, Shanxi Agricultural University, Taigu, Shanxi, People’s Republic of China School of Food Science and Engineering, Key Laboratory for Agricultural Products Processing of Anhui Province Hefei University of Technology Hefei China Jiangsu Cancer Centre Jiangsu Cancer Hospital Jiangsu Institute of Cancer Research The Affiliated Cancer Hospital of Nanjing Medical University Nanjing China Shenzhen Children Hospital, Shenzhen, China Department of Respiratory and Critical Care Medicine The Second Affiliated Hospital of Chongqing Medical University Chongqing China; Department of Respiratory and Critical Care Medicine The Second Clinical College of North Sichuan Medical College Nanchong China Division of Molecular Biology and Biochemistry, University of Missouri-Kansas City, Kansas City, Missouri, U.S.A. Hainan Provincial Center for Disease Control & Prevention, Haikou, Hainan, PR China. Electronic address: jkban702@163.com. Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210028, China; Jiangsu Provincial Academy of Traditional Chinese Medicine, Nanjing 210028, China College of Agriculture, Guangxi University, Nanning 530005, China. yiyian129846@126.com Department of Thoracic Cardiovascular Surgery, Tongji Hospital, Tongji University School of Medicine, Shanghai 200092, People's Republic of China Department of Cardiology Taishan People's Hospital Taishan China Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada State Key Laboratory of Quality Research in Chinese Medicine and Institute of Chinese Medical Sciences, University of Macau, Room 7003, N22 Building, Avenide da Universidade, Taipa, Macao 999078, China Emergency Center, The First Affiliated Hospital of Nanjing Medical University (Jiangsu Province Hospital) Jiangsu Province, China. Department of Respiratory and Critical Care Medicine, Ganzhou People's Hospital, 16 Meiguan Avenue, Ganzhou 341000, Jiangxi, China Department of Chemistry and Physiology and Functional Genomics, Center for Research at the Bio/Nano Interface, Shands Cancer Center, University of Florida, Gainesville, Florida 32611-7200, United States, Department of Polymer Engineering, The University of Akron, Akron, Ohio 44325-0301, United States College of Chemistry and Material Science, Food Safety Analysis and Test Engineering Technology Research Center of Shandong Province, Shandong Agricultural University, Taian 271018, P. R. China Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China Department of Endocrinology, Second Hospital of Jilin University Changchun 130000, China. The People’s Hospital of Baoan Shenzhen, Shenzhen, China Key Laboratory of Hubei Province for Digestive System Disease Department of Gastroenterology Renmin Hospital of Wuhan University Wuhan 430060 China School of Public Health, University of Alberta, Edmonton, Alberta, Canada Department of Biotherapy, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, and West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu, P.R. China Jiangsu Key Laboratory for the Research and Utilization of Plant Resources, Institute of Botany, Jiangsu Province and Chinese Academy of Sciences, Nanjing 210014, China School of Chemistry, Sun Yat-sen University, Guangdong, China; School of Marine Sciences, Sun Yat-Sen University, Guangzhou, China Department of Neurology, Nantong Third People’s Hospital, Affiliated Nantong Hospital 3 of Nantong University, Nantong 226006, Jiangsu, China The Eighth Affiliated Hospital Sun Yat‐sen University Shenzhen 518033 P. R. China Institute of Hematology and Oncology, Beijing Aerospace General Hospital, Beijing 100076, China. Division of Cardiology, Department of Medicine, The University of Hong Kong, Queen Mary Hospital; Division of Cardiology, Department of Medicine, The University of Hong Kong Shenzhen Hospital Northwest University for Nationalities, Lanzhou, Gansu 730030, China State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Fujian 361005, China. Clinical laboratory of BGI Health BGI‐Shenzhen Shenzhen China School of Environmental and Chemical Engineering, Jiangsu University of Science and Technology, Mengxi Road No. 2, Zhenjiang, 212003, P. R. China Department of Respiratory Disease, The Second Affiliated Hospital of Guangxi Medical University, Guangxi Medical University, Nanning, Guangxi, China (mainland) State Key Laboratory for Conservation and Utilization of Subtropical Agro‐bioresources South China Agricultural University Guangzhou China *Department of Immunology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, People’s Republic of China; Shenzhen Institute of Information Technology, Shenzhen, Guangdong 518000, P.R.China.chenyan@sziit.edu.cn. Department of Respiratory Medicine, Second Xiangya Hospital, Central South University, Xiangya Medical School, Changsha 410011, China. Department of Otolaryngology, Eye, Ear, Nose & Throat Hospital, Shanghai Key Clinical Disciplines of Otorhinolaryngology, Fudan University, Shanghai, People's Republic of China Department of Clinical Laboratory, Beijing Tuberculosis Thoracic Tumor Institute & Capital Medical University Affiliated Beijing Chest Hospital, Beijing, China Department of Respiratory Medicine, the Second Xiangya Hospital, Central-South University, Changsha 410011, China. Department of Ultrasound, Shenzhen Hospital of Southern Medical University, Shen Zhen, China State Key Laboratory of Fine Chemicals, Frontiers Science Center for Smart Materials, School of Chemical Engineering, Dalian University of Technology, Dalian 116024, China Department of Biology, University of Rochester, Rochester NY, 14627; and State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources and Key Laboratory of Natural Pesticide and Chemical Biology, Ministry of Education, South China Agricultural University, Guangzhou, Guangdong 510642, People’s Republic of China Division of Pharmacy Practice and Administrative Sciences, College of Pharmacy, UC Department of Neurology, Second Affiliated Hospital of Harbin Medical University, 246 Xuefu Road, 150086, Harbin, China Department of Respiratory Medicine, Nanchong Hospital, Nanchong, Sichuan 637000. Research & Development, SeekIn Inc., Shenzhen, China State Key Laboratory for Conservation and Utilization of Subtropical Agro‐Bioresources South China Agricultural University Guangzhou China School of Resources and Environmental Engineering; Shandong Agriculture and Engineering University; Jinan 250100; China From the Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis; the Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis; the Walther Oncology Center, Indiana University School of Medicine, Indianapolis; and the Walther Cancer Institute, Indianapolis, IN. School of Mathematics and Physics, North China Electric Power University, Beinong Road 2, Changping, Beijing, 102206, P. R. China; Institute of Clusters and Low Dimensional Nanomaterials, North China Electric Power University, Beinong Road 2, Changping, Beijing, 102206, P. R. China; School of New Energy, North China Electric Power University, Beinong Road 2, Changping, Beijing, 102206, P. R. China WuXi AppTec, Shanghai, China College of Environmental and Chemical Engineering, Shanghai University, Shanghai, P.R. China Department of Hematology, Lanzhou General Hospital, Lanzhou Military Area of PLA, Lanzhou 730050, China. Department of Obstetrics and Gynecology, and State Key Laboratory of Molecular Oncology, Cancer Institute, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Science, Beijing, People's Republic of China. Department of Neurology The Second Xiangya Hospital Central South University Changsha China Department of Pediatrics, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China Hainan Provincial Center for Disease Control and Prevention Haikou Hainan 57023 China Department of Diagnostic Radiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China Northern Jiangsu People's Hospital Affiliated to Yangzhou University/Clinical Medical College Yangzhou University Yangzhou Jiangsu China Department of Oral Pathology Peking University School and Hospital of Stomatology Beijing China Department of Neurosurgery The Second Hospital of Jilin University Changchun Jilin 130021 P. R. China Department of Statistics, University of Michigan, Ann Arbor, MI, USA Department of Neurology, Tianjin Huanhu Hospital, Tianjin 300350, P.R. China Department of Surgery, University of Western Australia, Royal Perth Hospital, Perth 6001, Australia Department of Pediatrics, Affiliated Hospital of Zunyi Medical University, Zunyi 563003，Guizhou Province, China,E-mail: cyz600@ 163.com. Yangtze University; Institute for Ocean Engineering, Shenzhen International Graduate School, Tsinghua University Department of Laboratory Medicine, Changhai Hospital, Second Military Medical University, Shanghai, China Laboratory for Electrochemical Interfaces, Department of Nuclear Science and Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States Shanghai Institute of Organic Chemistry (SIOC), Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, China, and Department of Chemistry, Shanghai Jiaotong University, 800 Dongchuan Lu, Shanghai 200240, China Nursing Department Office, Nanjing Drum Tower Hospital the Affiliated Hospital of Nanjing University Medical School Nanjing Jiangsu China Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences 1 , Shenzhen 518055, People's Republic of China Department of Pediatrics, The First People's Hospital of Jining, Jining, Shandong 272000, P.R. China School of Chemistry and Chemical Engineering, Anhui University, Hefei 230601, P. R. China School of Biological and Chemical Sciences Queen Mary University of London UK Center of Dental Implantation, Peking University School and Hospital of Stomatology, Beijing 100081, China. Authors' Affiliations: 1MacroGenics, Inc., South San Francisco, California and 2MacroGenics, Inc., Rockville, Maryland State Key Laboratory of Soil and Sustainable Agriculture, Institute of Soil Science, Chinese Academy of Sciences, Nanjing, Jiangsu Province 210008, China The Second Department of Pediatrics, Affiliated Hospital of Zunyi Medical College, Zunyi 563003, Guizhou Province, China. E-mail: cyz600@163.com. Department of Clinical Laboratory Fujian Cancer Hospital Fujian Medical University Cancer Hospital Fuzhou China Comprehensive Liver Cancer Center, the Chinese PLA 302th Hospital, Beijing, PR China University of Alberta, Edmonton, School of Public Health Alberta, Edmonton, Alberta, Canada Department of Molecular and Cell Biology, Millennium Pharmaceuticals, Inc., Cambridge, Massachusetts 02139, USA. Deparment of Gynecology, People’s Hospital of Jingjiang, Jingjiang 214500, China Department of Nephrology, Chongqing Western Hospital, Chongqing 400052, China. Department of Neurology Hubei Provincial Hospital of Integrated Chinese and Western Medicine Wuhan China Anhui Key Laboratory of Ecological Engineering and Biotechnology; School of Life Sciences; Anhui University; Hefei 230601; China Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, Department of Respiratory Disease, Second Affiliated Hospital of Guangxi Medical University, Guangxi Medical University Nanning, China. Department of Gastroenterology, Second Affiliated Hospital of Medical College, Zhejiang University, Hangzhou 310009, Zhejiang Province, China. chenyan72_72@hotmail.com Institute of Biomedical and Health Engineering; Shenzhen Institutes of Advanced Technology; Chinese Academy of Sciences; Shenzhen; China School of Chemistry and Chemical Engineering Guangxi Key Laboratory of Electrochemical Energy Materials Guangxi Colleges and Universities Key Laboratory of Applied Chemistry Technology and Resource Development Guangxi University Nanning 530004 China Department of Gynecology, Women's Hospital, Zhejiang University School of Medicine, Hangzhou 310006, China. National Institute of Metrology; Beijing 100013; China 0000 0004 1761 2484 grid.33763.32 Key Laboratory of Systems Bioengineering (Ministry of Education) Tianjin University 300072 Tianjin People’s Republic of China; 0000 0004 1761 2484 grid.33763.32 SynBio Research Platform, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), School of Chemical Engineering and Technology Tianjin University 300072 Tianjin People’s Republic of China Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Graduate School of the Chinese Academy of Sciences, Shanghai, China; National Laboratory for Infrared Physics, Shanghai Institute of Technical Physics, Chinese Academy of Sciences, 500 Yu Tian Road, Shanghai 200083, China; University of Chinese Academy of Sciences, 19 Yuquan Road, Beijing 100049, China State Key Laboratory of Food Science and Technology Nanchang University Nanchang China College of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China. crh8888@126.com College of Landscape Architecture, Central South University of Forestry and Technology, Changsha 410004, China; Hunan Big Data Engineering Technology Research Center of Natural Protected Areas Landscape Resources, Changsha 410004, China Vanderbilt Eye Institute, Vanderbilt University Medical Center, Nashville, Tennessee 37232, and Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, and Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia 30322 Department of Pediatrics, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China Department of Radiology, West China Second University Hospital, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, Sichuan Provence, China. Department of Neurology , The Second Hospital of Tianjin Medical University , Tianjin , 300211 , P.R. China Department of Cardiology Tongji Hospital Tongji University School of Medicine Shanghai China School of Port and Transportation Engineering; Zhejiang Ocean University; Zhoushan 316022; People's Republic of China Center for Clinical Mass Spectrometry, College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu 215123, China Department of Oral Pathology Peking University School and Hospital of Stomatology & National Center of Stomatology & National Clinical Research Center for Oral Disease & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices & Beijing Key Laboratory of Digital Stomatology & Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health & NMPA Key Laboratory for Dental Materials Beijing People's Republic of China University of Alberta School of Public Health, Edmonton, Alberta, Canada School of Chemistry and Chemical Engineering; Xuzhou University of Technology; Xuzhou 221018; China Key Laboratory of Animal (Poultry) Genetics Breeding and Reproduction, Ministry of Agriculture and Rural Affairs, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, China Cancer Research Institute Southern Medical University Guangzhou China Center for Research at Bio/Nano Interface, Department of Chemistry and Shands Cancer Center, University of Florida Genetics Institute, University of Florida, Gainesville, Florida 32611-7200, Department of Chemistry, Columbia University, New York, New York 10027, and Key Laboratory for Chemical Biology of Fujian Province, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, P.R. China Jiangsu Key Laboratory of Neurodegeneration, Nanjing Medical University, Nanjing, Jiangsu 211166, China. Shandong institute of brain science and brain-inspired research, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong 250117, China. Shanghai Institute of Technical Physics, Chinese Academy of Sciences, Shanghai 200083, China Key Laboratory of South China Agricultural Plant Molecular Analysis and Genetic Improvement, Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou, People’s Republic of China; Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, People’s Republic of China Department of Ophthalmology, Dean McGee Eye Institute, University of Oklahoma Health Sciences Center , Oklahoma City, Oklahoma 73104, USA Key Laboratory of Trace Element Nutrition of National Health Commission of the People’s Republic of China, National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, Beijing 100050, China Department of Dermatology The Affiliated Hospital of Southwest Medical University Luzhou China Life Sciences College of Nanjing Agricultural University, Nanjing 210095, Jiangsu, China Hainan Key Laboratory for Conservation and Utilization of Tropical Marine Fishery Resources, Sanya, Hainan, China;; College of Life Science and Ecology, Hainan Tropical Ocean University, Sanya, China; Traditional Chinese Medicine College, Ningxia Medical University, Yinchuan 750004, Ningxia Hui Autonomous Region, China Femtosecond Research Center Department of Biochemistry, Tufts University School of Medicine, Boston, MA 02111 Department of Respiratory Medicine The Second Affiliated Hospital of Guangxi Medical University Nanning China Shandong Normal University, China Anhui Key Laboratory of Modern Biomanufacturing Anhui University Jiulong Road 111 Hefei 230601 China Center of Therapeutic Research for Hepatocellular Carcinoma Beijing 302nd Hospital Beijing 100039 China Affiliated Hospital of Integrated Traditional Chinese and Western Medicine Nanjing University of Chinese Medicine 100 Hongshan Road Nanjing 210028 P. R. China; Jiangsu Provincial Academy of Traditional Chinese Medicine 100 Hongshan Road Nanjing 210028 P. R. China University of Alberta, Calgary, Canada Department of Earth and Environmental Engineering, Columbia University, New York, New York 10027, United States National Clinical Research Center for Metabolic Diseases, Key Laboratory of Diabetes Immunology (Central South University), Ministry of Education, and Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University, Changsha 410011, Hunan, China Department of Developmental Genetics, School of Basic Medical Sciences, Nanjing Medical University, Nanjing, China School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China. Cancer Institute, The 3rd Affiliated Hospital of Kunming Medical College, Yunnan University, Kunming 650091, China Department of Orthopaedics, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China University of Defense Technology Zhejiang Provincial Engineering Technology Research Center of Marine Biomedical Products, School of Food and Pharmacy, Zhejiang Ocean University;, Email: cyancy@zjou.edu.cn. College of Forestry, Northeast Forestry University, Harbin, People’s Republic of China College of Marine Ecology and Environment, Shanghai Ocean University, Shanghai 201306, China Department of Colorectal Surgery, Huzhou Central Hospital, Huzhou, Zhejiang 313000, P.R. China Tianjin Key Laboratory of Molecular Optoelectronic Sciences, Department of Chemistry, School of Science, Tianjin University and Collaborative Innovation Center of Chemical Science and Engineering, Tianjin 300072, P. R. China Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences Fuzhou 350002 P. R. China; School of Physical Science and Technology ShanghaiTech University Shanghai 201210 China; University of the Chinese Academy of Sciences Beijing 100039 P. R. China Department of Anesthesiology, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province 650032, PR China Department of Obstetrics, International Peace Maternity and Child Health Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China Medical Faculty, Kunming University of Science and Technology, Kunming, China Department of Neurology, Affiliated Drum Tower Hospital of Nanjing University, Medical School, Nanjing, China School of Pharmacy; Tongji Medical College; Huazhong University of Science and Technology; Wuhan 430030; P. R. China College of Pharmacology Sciences Zhejiang University of Technology, Hangzhou 310014, P. R. China Department of Chemistry, University of Florida, Gainesville, Florida 32611-7200, United States Faculty of Material Science and Engineering, Kunming University of Science and Technology, Kunming 650093, China Institute of Optoelectronics Shanghai Frontier Base of Intelligent Optoelectronics and Perception Fudan University Shanghai 200433 China School of Chemistry and Materials Science, Jiangsu Key Laboratory of Green Synthesis for Functional Materials, Jiangsu Normal University, Xuzhou, Jiangsu 221116, China Department of Operating Room, Suzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou, Jiangsu, China Department of Chemistry, University of Nebraska-Lincoln , Lincoln , NE 68588, USA College of Life Science and Engineering, Northwest University for Nationalities, 1 Xibei xin cun, Lanzhou 730030/Gansu Engineering Research Center for Animal Cell, Lanzhou 730030, China. Department of Gynecology and Obstetrics Affiliated Hospital of North Sichuan Medical College Sichuan China Department of Clinical Pharmacology, The Sixth People’s Hospital, Shanghai Jiao Tong University, Shanghai, China Department of Infectious Diseases, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310016, PR China Department of Obstetrics and Gynaecology, Faculty of Medical and Health Sciences, The University of Auckland, New Zealand; Department of Obstetrics and Gynaecology, Tengzhou Central People’s Hospital, Shandong Province, China Authors' Affiliations: 1Novartis Institutes for Biomedical Research, Cambridge, Massachusetts; 2Departments of Medicine and Cancer Biology; Breast Cancer Research Program, Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, Tennessee; 3MorphoSys AG, Martinsried, Germany; and 4Genomics Institute of the Novartis Research Foundation, San Diego, California Joint BioEnergy Institute Emeryville California USA; Biological Systems and Engineering Division Lawrence Berkeley National Laboratory Berkeley California USA Department of Neurology, The Second Hospital of Tianjin Medical University, Tianjin 300211, P.R. China Department of Respiratory, BenQ Medical Center, The Affiliated BenQ Hospital of Nanjing Medical University, Nanjing, China Department of Biology, Shanghai Normal University, 100 Guilin Road, Shanghai, 200234 P. R. China; Email: unknown. State Key Laboratory of Respiratory Disease, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.; Guangdong Pharmaceutical University, Guangzhou, China. Department of Chinese Medicine Jiangsu Cancer Hospital Nanjing P. R. China Ecological Security and Protection Key Laboratory of Sichuan Province, Mianyang Normal University, Mianyang, China Beijing University of Chemical Technology Beijing Advanced Innovation Center for Soft Matter Science and Engineering 100029 Beijing CHINA Section of Endocrinology; Diabetes and Metabolism; Department of Medicine; Temple University School of Medicine; Philadelphia Pennsylvania; Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease; Department of Cardiology; Tianjin Institute of Cardiology; Second Hospital of Tianjin Medical University; Tianjin China Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, China; Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing, China NHC Key Laboratory of Food Safety Risk Assessment, Chinese Academy of Medical Science Research Unit, China National Center for Food Safety Risk Assessment, Beijing, P.R. China Department of Emergency The First Affiliated Hospital of Nanjing Medical University 300 Guangzhou Road Nanjing 210029 China a Department of Agricultural and Biological Engineering , Purdue University , West Lafayette , IN , USA College of Chemistry and Materials Science Hebei Research Center of the Basic Discipline of Synthetic Chemistry Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education Key Laboratory of Chemical Biology of Hebei Province Hebei University No. 180 Wusi East Road, Baoding Hebei 071002 China College of Life and Environmental Sciences, Hangzhou Normal University , Hangzhou, Zhejiang 311121 , P.R. China Department of Clinical Laboratory, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China Chengdu China School of Public Health, Wannan Medical College, 241002, China Tumor Institute, The Third Affiliated Hospital of Kunming Medical University, Tumor Hospital of Yunnan Province, Kunming, China School of Medicine, Hunan University of Chinese Medicine Changsha, Hunan, China. State Key Laboratory of Natural Medicines Jiangsu Key Laboratory of Carcinogenesis and Intervention, China Pharmaceutical University Nanjing People's Republic of China Institute of Traditional Chinese Medicine, South Medical University, Guangzhou 510515, China. Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China Chemical and Engineering Materials Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831, United States Princess Margaret Cancer Centre/Ontario Cancer Institute, University Health Network, 101 College Street, Toronto, Ontario M5G 1L7, Canada. Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, People’s Republic of China The Second Department of Pediatrics, The Affiliated Hospital of Zunyi Medical College, Guizhou Children's Hospital, Zunyi 563000, Guizhou Province, China. E-mail: cyz600@163.com. Jiangsu Provincial Key Lab of Pulp and Paper Science and Technology; Jiangsu Co-innovation Center of Efficient Processing and Utilization of Forest Resources; Nanjing Forestry University; Nanjing 210037; China Department of Obstetrics Beijing Chaoyang District Maternal and Child Health Care Hospital Beijing China Department of Pulmonary and Critical Care Medicine, The Second Xiangya Hospital, Central South University, Changsha 410011, Hunan, China; Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA Spire Sciences, Inc., Boca Raton, FL, USA Guangdong Provincial Key Laboratory of Orthopaedics and Traumatology, Department of Spinal Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China Department of Neurology, Beijing Changping Hospital of Traditional Chinese Medicine, Beijing 102200, China. State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, Fujian Province, China The First College of Clinical Medicine Nanjing University of Chinese Medicine Nanjing Jiangsu China State Key Laboratory of Traditional Chinese Medicine Resources in Southwest China, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China State Key Laboratory of Nonlinear Mechanics, Institute of Mechanics, Chinese Academy of Sciences, Beijing, China 100190 Prenatal Diagnostic Center, International Peace Maternal and Children's Hospital Shanghai Jiaotong University Shanghai China Division of Cardiology Department of Medicine University of Hong Kong Queen Mary Hospital Hong Kong China; Division of Cardiology Department of Medicine University of Hong Kong Shenzhen Hospital Hong Kong China Department of Endocrinology, West China Hospital, Sichuan University, Chengdu 610041, China Department of Neurology The Second Hospital of Tianjin Medical University Tianjin People's Republic of China Department of Respiratory and Critical Care Medicine, the Second Xiangya Hospital, Central South University, Changsha, Hunan, China State Key Laboratory of Bioelectronics, Jiangsu Laboratory for Biomaterials and Devices, School of Biological Science and Medical Engineering, South east University, Dingjiaqiao 87, Nanjing, 210009, Jiangsu, PR China CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics University of Chinese Academy of Sciences, Chinese Academy of Sciences Beijing China Department of Integrated TCM & Western Medicine, Central Hospital of Yiyang city, YiyangHunan, 413200, China State Key Laboratory of Infrared Physics Shanghai Institute of Technical Physics Chinese Academy of Sciences 500 Yu Tian Road Shanghai 200083 China State Key Laboratory of Natural Medicines; Department of Pharmacognosy; China Pharmaceutical University; Nanjing; China Institute of Biopharmaceutical Research, Liaocheng University, Liaocheng 252059, P. R. China National Clinical Research Center for Metabolic Diseases, Key Laboratory of Diabetes Immunology (Central South University), Ministry of Education, and Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University , Changsha 410011, Hunan , China Department of Biological Sciences Virginia Tech Blacksburg VA 24061 USA Laboratory of Molecular Biology and Bovine Breeding, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing, China Division in Signaling Biology; Princess Margaret Cancer Center; University Health Network; Toronto Canada Department of Nephrology, The Second Affiliated Hospital of Nanchang University, Nanchang, China Department of Neurosurgery Fujian Medical University Union Hospital Fuzhou China College of Agriculture and Bioengineering Heze University Heze China Department of Radiology, The First Affiliated Hospital, Sun Yat-sen University, 58 Zhongshan Second Rd, Yuexiu District, Guangzhou, Guangdong 510080, PR China Department of Cardiology, National Clinical Research Center for Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing , China Zhejiang Provincial Engineering Technology Research Center of Marine Biomedical Products, School of Food and Pharmacy Zhejiang Ocean University Zhoushan China Department of Pulmonary and Critical Care Medicine, Second Xiangya Hospital; Research Unit of Respiratory Disease; Diagnosis and Treatment Centre of Respiratory Disease, Central South University, Changsha, Hunan, China; Clinical Medical Research Centre for Respiratory and Critical Care Medicine in Hunan Province, China Department of Gastroenterology, Yidu Central Hospital of Weifang, Weifang, Shandong, China (mainland) School of Rehabilitation Medicine, Henan University of Chinese Medicine, Zhengzhou 450046, China. From the Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China. The First Affiliated Hospital of Zhejiang Chinese Medical University, China Institute of Horticultural Biotechnology, Fujian Agriculture and Forestry University, Fuzhou 350002, China Department of Clinical Laboratory, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, China Department of Radiology, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China (mainland) Division of Cancer and Stem Cells, University of Nottingham, Nottingham, UK Lingnan Normal University, Zhanjiang, China State Key Laboratory of Infrared Physics Shanghai Institute of Technical Physics Chinese Academy of science 500 Yutian Road Shanghai 200083 China School of Advanced Materials, Peking University Shenzhen Graduate School, Shenzhen 518055, China Guangdong Provincial Key Laboratory of Orthopedics and Traumatology, Department of Spinal Surgery, First Affiliated Hospital of Sun Yat-sen University, Guangzhou 51008, P. R. China. School of Materials Science and Engineering, Jiangsu University Department of Rehabilitation Medicine, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China (mainland) Department of Thoracic Surgery Shanghai Pulmonary Hospital, Tongji University School of Medicine Shanghai China Department of Neonatology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing 100045, China State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering; Key Laboratory of Green Pesticide and Agricultural Bioengineering; Ministry of Education; Center for Research and Development of Fine Chemicals; Guizhou University Department of Respiratory and Critical Care Medicine, The Second Hospital of Shanxi Medical University, Taiyuan, Shanxi, China (mainland) Department of Pharmaceutics, School of Pharmacy, Nantong University, Nantong 226001, China Department of Gastroenterology Characteristic Medical Center of Strategic Support Army Beijing China Department of Oncology Zhongda Hospital School of Medicine Southeast University Nanjing China Department of Orthopaedics & Traumatology, Li Ka Shing Faculty of Medicine; The University of Hong Kong; Hong Kong China Department of Dermatology The First Affiliated Hospital of Guangzhou University of Chinese Medicine Guangzhou China; The First Clinical Academy Guangzhou University of Chinese Medicine Guangzhou China; Department of Dermatology Yangjiang People's Hospital Yangjiang China Department of Chemistry and Waksman Institute, Rutgers University, New Brunswick, New Jersey 08855 Femtosecond Application and Research (Guangzhou) Guangzhou China Emergency Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China School of Public Health Institute of Chronic Disease Control and Prevention, Wannan Medical College Wuhu 241002 Anhui China University of Otago Department of Gastrointestinal Surgery, The First Hospital of Jilin University, Changchun 130021, P. R. China National Laboratory for Oncogenes and Related Genes, Cancer Institute of Shanghai Jiao Tong University, Shanghai 200032, People's Republic of China; Shanghai Research Center of Biotechnology, Chinese Academy of Sciences, Shanghai 200233, People's Republic of China; and BioInfo Bridge, 16905 George Washington Drive, Rockville, MD 20853 Chinese Academy of Inspection and Quarantine Beijing China Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai 200031, China From the Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai, China. Institute of Animal Science, Chinese Academy of Agricultural Science, Beijing, People’s Republic of China BGI Genomics, BGI-Shenzhen, Shenzhen 518083, China Longhua Hospital, Shanghai University of Traditional Chinese Medicine Shanghai China School of Material and Chemical Engineering, Xuzhou University of Technology, Xuzhou, 221018, People’s Republic of China Shanghai Key Laboratory of Orthopaedic Implants, Department of Orthopaedics, Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai China Shanghai Institute of Technical Physics Chinese Academy of Sciences Hongkou Shanghai 200083 China; Frontier Institute of Chip and System Institute of Optoelectronics Shanghai Frontier Base of Intelligent Optoelectronics and Perception Fudan University Shanghai 200438 China Hefei National Laboratory for Physical Sciences at the Microscale, Department of Chemical Physics, University of Science and Technology of China, Hefei 230026, China; National Institute of Metrology, Beijing, 100013, China Epilepsy Center, Shenzhen Children's Hospital, Shenzhen, Guangdong 518038, P.R.China. The Affiliated Hospital of Zunyi Medical College/The Children's Hospital of Guizhou Province , Zunyi 563003, Guizhou Province, China.E-mial: cyz600@163.com. Department of Materials Science and Engineering, ‡Department of Mechanical Engineering, and §Materials Characterization Facility, Texas A&M University, College Station, Texas 77843, United States Joint Centre of Translational Medicine, Department of Orthopaedics, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, 325000, P. R. China; School of Ophthalmology and Optometry, Eye Hospital, School of Biomedical Engineering, Wenzhou Medical University, Wenzhou, Zhejiang Province, 325035, P. R. China; Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang Province, 325001, P. R. China Laboratory for Electrochemical Interfaces, ‡Department of Nuclear Science and Engineering, §Department of Materials Science and Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States The School of Public Health, Peking University, Beijing 100083, China. Chinese Academy of Inspection and Quarantine, Beijing, China. School of Chemistry and Materials Science; Jiangsu Normal University; Xuzhou; P. R. China Key Laboratory of Nutrition and Metabolism Institute for Nutritional Sciences Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Graduate School of the Chinese Academy of Sciences Shanghai China Department of Immunology, Tianjin Key Laboratory of Cellular and Molecular Immunology, Key Laboratory of Diseases and Microenvironment of Ministry of Education of China, Tianjin Medical University, Tianjin, China Department of Medical and Molecular Genetics, Walther Oncology Center, Indiana University School of Medicine and Walther Cancer Institute, Indianapolis, Indiana 46202, Pathology and Physiology Research Branch, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, and Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390-9046 Hainan Key Laboratory for Conservation and Utilization of Tropical Marine Fishery Resources, College of Life Science and Ecology, Hainan Tropical Ocean University, Sanya, PR China; Department of Pediatrics, Affiliated Hospital of Zunyi Medical College, Zunyi, Guizhou, China (mainland) Taizhou Hospital of Traditional Chinese Medicine, Taizhou, China. Hepatobiliary Surgery Institute, Southwest Hospital, Army Medical University, Chongqing, China Department of Pediatrics,Affiliated Hospital of Zunyi Medical University,Zunyi 563003,Guizhou Province,China. E-mail: cyz600@163 com. Jiangsu Province Key Laboratory of Neurodegeneration, Center for Global Health, Nanjing Medical University , Nanjing , China; Brain Institute, the Affiliated Nanjing Brain Hospital of Nanjing Medical University , Nanjing , China Department of Food & Bioproduct Sciences, University of Saskatchewan, Saskatoon, Saskatchewan, Canada Department of Stomatology, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, China. From the Vanderbilt Eye Institute, Vanderbilt University Medical Center, Nashville, Tennessee; and REMAP-CAP Writing Committee for the REMAP-CAP Investigators Comprehensive Liver Cancer Center,The Fifth Medical Center of PLA General Hospital,Beijing,China Department of Neurology, Second Affiliated Hospital of Harbin Medical University, Harbin, China School of Chemical Engineering, Xuzhou Institute of Technology, Xuzhou 221111, China Department of Epidemiology, University of Washington, Seattle, Washington; Kidney Research Institute, Seattle, Washington State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry, Jilin University, Changchun 130012, P.R. China Department of Traditional Chinese Medicine, The First Affiliated Hospital, Sun Yat-sen University, 58 Zhongshan Road II, Guangzhou 510080, China Department of Internal Medicine, ‡Department of Biomedical Engineering, §Department of Radiology, ∥Department of Biostatistics, ⊥Department of Pathology, and #Department of Mechanical Engineering, University of Michigan, Ann Arbor, Michigan 48109, United States Nanjing Stomatological Hospital Medical School of Nanjing University Nanjing China Department of Respiratory Medicine, the Third Hospital, Peking University, Beijing, China. Department of Psychiatry, The Fourth Affiliated Hospital, Zhejiang University, School of Medicine, Yiwu Department of Gastroenterology, Pu’ai Hospital, Tongji Medical College, Huazhong University of Science and Technology, 50 Gu Tian San Road, Wuhan 430034, China College of Food Science and Engineering; Jilin University; Changchun 130062; People's Republic of China School of Chemistry and Chemical Engineering; College of Materials Science and Engineering; Shandong Provincial Key Laboratory/Collaborative Innovation Center of Chemical Energy Storage, Liaocheng University, Liaocheng 252059, China School of Medicine Department of Oncology Southeast University Zhongda Hospital Nanjing China Shanghai Key Laboratory of Brain Functional Genomics, Key Laboratory of Brain Functional Genomics, Ministry of Education, School of Psychology and Cognitive Science, East China Normal University, Shanghai, China Analysis Group, Los Angeles, California Zhejiang Provincial Engineering Technology Research Center of Marine Biomedical Products , School of Food and Pharmacy, Zhejiang Ocean University, Zhoushan 316022 , China Department of Chemistry, University of Illinois at Chicago, 845 West Taylor Street, Chicago, Illinois 60607, Department of Biological Chemistry, Finch University of Health Sciences/The Chicago Medical School, North Chicago, Illinois 60616, and Merck Research Laboratories, West Point, Pennsylvania 19486, and Rahway, New Jersey 07065 Department of Thoracic Surgery Shanghai Pulmonary Hospital Tongji University School of Medicine Shanghai 200092 P. R. China Department of Pediatrics Jining No. 1 People's Hospital Jining Shandong China Department of Hand Surgery, Wuhan Fourth Hospital; Puai Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430033, China School of Physics and Astronomy, University of Minnesota, Minneapolis, MN 55455 Department of Urology, Shanghai Children's Hospital, School of Medicine Shanghai Jiao Tong University Shanghai China 1MacroGenics, Inc., Brisbane, California. School of Physics and Astronomy, University of Minnesota, Minneapolis, Minnesota 55455, United States Pharmacoepidemiology and Pharmacoeconomics, Department of Pharmacy Practice and Administrative Sciences, School of Pharmacy, University of Cincinnati Medical Center, Cincinnati, OH Center for Medical Genetics, School of Life Sciences, Central South University, Changsha 410078, China College of Food Science and Engneering, Jilin University, Changchun, People’s Republic of China School of Chemistry and Chemical Engineering; South China University of Technology; 510640 Guangzhou; China Department of Aerospace Physiology Fourth Military Medical University Xi'an China Department of Pediatrics, Union Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China Department of Food Science, Swedish University of Agricultural Sciences (SLU), Box 7051, SE-750 07 Uppsala, Sweden Department of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Hunan 410078, China School of Life Sciences Anhui University Hefei China; Key Laboratory of Eco‐engineering and Biotechnology of Anhui Province Anhui University Hefei China First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, China From the Vanderbilt Eye Institute, Vanderbilt University Medical Center, Nashville, Tennessee; and the Department of Burns, State Key Laboratory of Trauma, Burn and Combined Injury, Institute of Burn Research, Southwest Hospital, Third Military Medical University (Army Medical University) , Chongqing , China Schizophrenia Program, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai Key Laboratory of Psychotic Disorders, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Innovative Research Team of High-Level Local Universities in Shanghai, Shanghai, China Joint BioEnergy Institute, Emeryville, California 94608, United States; Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States Inflammation and Immunology, Pfizer Inc, Collegeville, PA, USA Department of Computer Information Systems, Borough of Manhattan Community College, City University of New York, New York, NY. Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, China Department of Exercise Biochemistry, Exercise Science School, Beijing Sport University, Beijing, Peking, China Institute of Comparative Medicine and Laboratory Animal Center, Southern Medical University, Guangzhou 510515, China State Key Laboratory of Complex Severe and Rare Diseases, Medical ICU, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, China Department of Genetic Identification, Erasmus MC University Medical Center Rotterdam, Rotterdam, Netherlands.; Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China.; University of Chinese Academy of Sciences, Beijing, China. The Hong Kong Polytechnic University 1 Department of Applied Physics and Materials Research Centre, , Hong Kong, China Bioengineering, California Institute of Technology, Pasadena, CA, USA. Alberta Health School of Food and Biological Engineering, Chengdu University, Chengdu 610106, China Tsinghua University; Yangtze University Research Unit of Food Safety, Chinese Academy of Medical Sciences (No. 2019RU014): NHC Key Laboratory of Food Safety Risk Assessment, China National Center for Food Safety Risk Assessment (CFSA), Beijing, China. Department of Blood Purification, Hubei University of Medicine, Shiyan, China School of Sport Medicine and Rehabilitation, Beijing Sport University, Beijing Department of Hematology, Xiangya Hospital of Central South University, Changsha 410008, China. Department of Disease Control, Health and Family Planning Commission of Hunan Province Medical College, Anhui University of Science and Technology School of Pharmacy, Shanghai Jiao Tong University Shanghai 200240, China. Cancer Research Institute, Southern Medical University, Guangzhou 510515, China Department of Polymer Materials and Engineering, School of Materials and Chemical Engineering, Anhui Jianzhu University, 230601, China Department of Orthopedics, Zhongnan Hospital of Wuhan University, No. 169, Donghu Road, Wuhan 430071, China Department of Neonatology Xinhua Hospital Shanghai Jiaotong University School of Medicine Shanghai China Emergency Department, The Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116023, P.R. China Department of Chemistry, Boston University, 590 Commonwealth Avenue, Boston, Massachusetts 02215 State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150001, People’s Republic of China; Department of Radiochemistry China Institute of Atomic Energy Beijing China Division of Cardiology, Department of Medicine Queen Mary Hospital, The University of Hong Kong Hong Kong China Global Health Research Center Duke Kunshan University Kunshan Jiangsu China; School of Public Health Wuhan University Wuhan Hubei China Department of Gastroenterology, The First Affiliated Hospital of Henan University of Science and Technology , Luoyang 471003, Henan , China Department of Oncology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, China (mainland) Ultrasound Medical Center, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China Department of Basic Veterinary Medicine College of Animal Science and Veterinary Medicine Huazhong Agricultural University Wuhan Hubei 430070 China Department of Laboratory Diagnosis, Changhai Hospital Second Military Medical University 168 Changhai Road Shanghai 200433 China Zhejiang Provincial Key Laboratory of Solid Waste Treatment and Recycling, College of Environmental Science and Engineering, Zhejiang Gongshang University, Hangzhou, 310018, China; College of Environmental and Chemical Engineering, Shanghai University, 99 Shangda Road, Shanghai 200444, China From the Department of Pharmacology, Vascular Cell Signaling and Therapeutics Program, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, Conn. The present address for R.D.R. is the Center for Experimental Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, Pa. Department of Respiratory and Critical Care Medicine, The Second Hospital of Shanxi Medical University, Taiyuan 030001, P.R. China Traditional Chinese Medicine College of Ningxia Medical University, Yinchuan 750004, China Dept. of Stomatology, The PLA General Hospital, Beijing 100853, China. State Key Laboratory for Biology of Plant Diseases and Insect Pests Institute of Plant Protection Chinese Academy of Agricultural Sciences Beijing China; College of Life Sciences Sichuan University Chengdu China International Center for Applied Mechanics State Key Laboratory for Strength and Vibration of Mechanical Structures School of Aerospace Xi'an Jiaotong University Xi'an 710049 China School of Applied Physics and Materials, Wuyi University, No. 22, Dongcheng Village, Jiangmen 529020, Guangdong, P. R. China School of Biological and Chemical Engineering, Nanyang Institute of Technology, Nanyang, China; Henan Key Laboratory of Industrial Microbial Resources and Fermentation Technology, Nanyang Institute of Technology, Nanyang, China Department of Endocrinology The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China Hefei China Department of Immunology, School of Basic Medical Sciences Capital Medical University Beijing China Elekta Ltd. Asia Pacific Hongkong China Department of Gastroenterology, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, P. R. China Department of Pathology, Shanghai Huadong Hospital, Fudan University, Shanghai 200333, China. Computer Information Systems Department, BMCC, CUNY, New York, New York, USA Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai 200031, China Centre for Hyperbaric Oxygen and Neurorehabilitation, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou, China Key Laboratory of Applied Chemistry of Hebei Province College of Environmental and Chemical Engineering Yanshan University 066004 Qinhuangdao P. R. China NHC Key Laboratory of Thrombosis and Hemostasis, Jiangsu Institute of Hematology, National Clinical Research Center for Hematologic Diseases The First Affiliated Hospital of Soochow University Suzhou China Department of Nephrology The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University Wenzhou 325027 China Second Department of Pediatrics, Zunyi Medical University，Affiliated Hospital of Zunyi Medical University，The Children's Hospital of Guizhou Province，Zunyi 563003，Guizhou Province，China,E-mail: cyz600@163.com. State Institution of Drug Clinical Trials, Guangdong Second Provincial General Hospital, Guangzhou, Guangdong, China. Department of Pediatric, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China Authors' Affiliations: 1Aflac Cancer Center, Emory University, Atlanta, Georgia; 2Fred Hutchinson Cancer Research Center, University of Washington, Seattle, Washington; 3St. Jude Children's Research Hospital, Memphis, Tennessee; 4Baylor College of Medicine, Houston, Texas; 5Department of Public Health Sciences, School of Public Health, University of Alberta, Alberta, Canada; and 6Memorial Sloan-Kettering Cancer Center, New York, New York University of Cincinnati Medical Center, Ohio BGI‐Shenzhen Shenzhen 518083 China Department of Hepatobiliary Surgery, Nanfang Hospital,Southern Medical University,Guangzhou,China Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering, Department of Cell Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China Department of Cell Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, P.R. China Department of Physics, Laboratory for Fluorescence Dynamics, University of Illinois at Urbana-Champaign, 1110 West Green Street, Urbana, Illinois 61801 Laboratory for Electrochemical Interfaces, Department of Nuclear Science and Engineering, and ‡Department of Material Science and Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai, China Department of Clinical Laboratory, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou 350014, China State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources and Key Laboratory of Natural Pesticide and Chemical Biology, Ministry of Education, South China Agricultural University, Guangzhou, 510642 Guangdong, China Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), NMPA Key Laboratory for Research and Evaluation of Radiopharmaceuticals (National Medical Products Administration), Department of Nuclear Medicine, Peking University Cancer Hospital and Institute, Beijing 100142, China; Guizhou University School of Medicine, Guiyang, Guizhou 550025, People’s Republic of China Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, China. jxzscy@163.com State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, People’s Republic of China; College of Biomedical Engineering and Instrument Sciences, Zhejiang University, Hangzhou, People’s Republic of China Advanced Technology Research Institute, Beijing Institute of Technology, Furong Road, Changqing District, Jinan, Shandong 250307, China The Education Ministry Key Lab of Resource Chemistry, Shanghai Key Laboratory of Rare Earth Functional Materials, Optoelectronic Nano Materials and Devices Institute, Department of Chemistry, Shanghai Normal University, Shanghai 200234, China Department of Laboratory Hematology Laboratory Medicine Program University Health Network University of Toronto Toronto Ontario Canada; The First Affiliated Hospital of Nanchang University Nanchang China Department of Respiratory Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China Institute of Marine Biotechnology Collaborative Innovation Center of Deep Sea Biology School of Life Science Tsinghua University Beijing China Joint BioEnergy Institute Lawrence Berkeley National Laboratory Berkeley CA 94720 USA; Biological Systems and Engineering Division Lawrence Berkeley National Laboratory Berkeley CA 94720 USA Department of Ophthalmology University of Texas Medical Branch Galveston TX USA; Dean McGee Eye Institute University of Oklahoma Health Sciences Center Oklahoma City OK USA; Department of Biochemistry University of Oklahoma Health Sciences Center Oklahoma City OK USA Department of Life Science and Engineering, Harbin Institute of Technology Laboratory of Plant Nematology and Research Center of Nematodes of Plant Quarantine, Department of Plant Pathology, College of Plant Protection, South China Agricultural University, Guangzhou, P.R. China Borough of Manhattan Community College, New York, NY, USA. State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150001, People’s Republic of China. Department of Colorectal and Anal Surgery, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China Institute for Egg Science and Technology, School of Food and Biological Engineering, Chengdu University, Chengdu 610106, China From Eli Lilly and Co, Indianapolis, Ind, and the Angiogenesis Research Center (M.S.), Dartmouth Medical School, Lebanon, NH. Ontario Cancer Institute; University Health Network; Toronto Canada Department of Ultrasonic Diagnosis, Zhujiang Hospital of Southern Medical University, Guangzhou 510282, China University of Otago Department of Psychology PO Box 56 Dunedin 9054 New Zealand Institute for Integrative Nanosciences, IFW Dresden, Helmholtzstraße 20, 01069 Dresden, Germany Department of Pharmacy, Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong, PR China School of Mathematics and Physics; North China Electric Power University; Beijing 102206; China; Institute of Clusters and Low Dimensionals Institute of Rocket Force Medicine , State Key Laboratory of Trauma, Burns and Combined Injury, , 400038, Chongqing, China; Third Military Medical University (Army Medical University) , State Key Laboratory of Trauma, Burns and Combined Injury, , 400038, Chongqing, China Department of Infectious Diseases, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China Hainan Provincial Center for Disease Control and Prevention, Haikou 570203, China. Department of Materials Science & Engineering, Texas A&M University, College Station, Texas, USA. College of Microelectronics, College of Information Science and Electronic Engineering, Zhejiang University, Hangzhou 310027, China Department of Basic Medical College, Xinjiang Medical University, Xinshi, Urumqi, Xinjiang Uygur Autonomous Region 830011, P.R. China Department of Ophthalmology & Visual Sciences, University of Texas Medical Branch, Galveston, Texas, United States State Key Laboratory for Artificial Microstructure and Mesoscopic Physics, Department of Physics, Peking University, Beijing100871, China The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, Center for Information in Medicine School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 611731, P. R. China The Center of Gerontology and Geriatrics, West China Hospital Sichuan University Chengdu Sichuan China Department of Radiochemistry, China Institute of Atomic Energy, Beijing, China Department of Spine Surgery and Musculoskeletal Tumor Zhongnan Hospital of Wuhan University 168 Donghu Street, Wuchang District Wuhan Hubei 430071 P. R. China Institution of Drug Clinical Trial, Guangdong Second Provincial General Hospital, Guangzhou 510317, China ENT Institute and Otorhinolaryngology Department of Affiliated Eye and ENT Hospital, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai 200031, China; NHC Key Laboratory of Hearing Medicine, Fudan University, Shanghai 200031, China Guangdong Provincial Key Laboratory of Orthopedics and Traumatology, Department of Spinal Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China Department of Gastroenterology PLA Strategic Support Force Characteristic Medical Center Beijing China University of Alberta, Edmonton, Alberta, Canada Department of Pharmaceutical Sciences, College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu 215123, China Institute of Clinical Medicine, Urodynamic Center and Department of Urology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China Key Laboratory of Earth and Planetary Physics Institute of Geology and Geophysics, Chinese Academy of Sciences Beijing China School of Pharmacy, Shenzhen University Medical School, Shenzhen University, Shenzhen 518055, P. R. China Departments of 1Clinical Oncology and School of Pharmacy, Nantong University, Nantong, People’s Republic of China Department of Respiratory Medicine, The Second Xiangya Hospital of Central South University, Changsha, China Department of Discovery Chemistry, Bristol-Myers Squibb Research and Development, 5 Research Parkway, Wallingford, Connecticut, 06492, United States Authors' Affiliations: 1Key Laboratory of the Ministry of Education for Cell Biology and Tumor Cell Engineering, School of Life Sciences and 2Key Laboratory for Chemical Biology of Fujian Province, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, Fujian Province, P.R. China School of Metallurgy and Environment, Central South University, Changsha 410083, China School of Life Sciences, Xiamen University, Xiamen, China 361005, and Fisheries College, The Key Laboratory of Science and Technology for Aquaculture and Food Safety, and College of Biological Engineering, Jimei University, Xiamen, China 361021 Satellite Environment Application Center, Ministry of Ecology and Environment, Beijing 100094, China Department of Cardiology, Fuwai Hospital, Chinese Academy of Medical Sciences, Beijing, China Institute of Human Respiratory Disease, Xinqiao Hospital, The Third Military Medical University, Chongqing 400037, China Department of Clinical Laboratory, School of Medicine, Women’s Hospital, Zhejiang University, Zhejiang, Hangzhou, China School of Pharmacy State Key Laboratory of Functional Organic Molecular Chemistry Institute of Codonopsis Radix Lanzhou University 199 Dong-gang Road West Lanzhou 730000 P. R. China Guangdong Women and Children Hospital, Guangzhou, China Department of Computer Information Systems, BMCC, City University of New York, New York, USA. Obstetrics and Gynecology Hospital, Fudan University, China School of Resources and Environment, Anhui Agricultural University, Hefei 230036, China. chenyan_Chine@163.com Department of Stomatology, The First Affiliated Hospital College of Medicine, Zhejiang University Hangzhou China Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu 610041, China; Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu 610041, China Dalla Lana School of Public Health, University of Toronto, Toronto, Canada. Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut Department of Respiratory Medicine, the Second Xiangya Hospital, Research Unit of Respiratory Disease, Diagnosis and Treatment Center of Respiratory Disease, Central South University, Changsha, China State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People’s Republic of China Engineering Research Center of Large Scale Reactor Engineering and Technology; Ministry of Education; State Key Laboratory of Chemical Engineering; East China University of Science and Technology; Shanghai 200237 Laboratory of Molecular Biology and Bovine Breeding, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, China The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210029, China; Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210023, China Department of Respiratory and Critical Care Medicine, Shanghai Pulmonary Hospital, Institute of Respiratory Medicine Tongji University School of Medicine Shanghai China Oncologic Department, Jiangsu Province Hospital of TCM, Nanjing, Jiangsu 210029, China; Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210023, China Emergency Center, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China The James Buchanan Brady Urological Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland; Department of Urology, Johns Hopkins University School of Medicine, Baltimore, Maryland Department of Obstetrics and Gynecology, Suzhou Xiangcheng People’s Hospital, Suzhou, Jiangsu, China Panzhihua Center for Disease Control and Prevention, Panzhihua 617000, PR China Key Laboratory for Uighur Medicine, Institute of Materia Medica of Xinjiang, Urumqi, China Hainan Provincial Center for Disease Control and Prevention, Haikou, China; Department of Physiology, State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Carcinogenesis and Intervention, China Pharmaceutical University, Nanjing 210009, China Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China Pharma Technical Development, Genentech Inc, 1 DNA Way, South San Francisco, California, USA Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, Sichuan 610041, China; Joint Laboratory of Reproductive Medicine, Key Laboratory of Birth Defects and Related Diseases of Women and Children, West China Second University Hospital, Sichuan University, Chengdu, Sichuan 610041, China Department of Pathology Huadong Hospital, Fudan University Shanghai China University of Science and Technology of China, School of Cyber Science and Technology , Hefei , Anhui Province , China State Key Laboratory of Veterinary Biotechnology Harbin Veterinary Research Institute, CAAS Harbin P. R. China Department of Stomatology, Nanfang Hospital, Southern Medical University, Guangzhou, China Life Science and Technology School, Lingnan Normal University, Zhanjiang, Guangdong, China School of Advanced Materials Peking University Shenzhen Graduate School Shenzhen 518055 China Department of Stomatology, The 1st Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan, China (mainland) Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, USA Bristol Myers Squibb, Wallingford, Connecticut, USA Key Laboratory of Nutrition and Metabolism Institute for Nutritional Sciences Shanghai Institutes for Biological Sciences Graduate School of the Chinese Academy of Sciences Chinese Academy of Sciences Shanghai China; School of Life Sciences and Technology Shanghai Tech University Shanghai China School of Nursing Beijing University of Chinese Medicine Beijing China State Key Laboratory of Nonlinear Mechanics, Institute of Mechanics, Chinese Academy of Sciences, Beijing 100190, China; School of Engineering Sciences, University of Chinese Academy of Sciences, Beijing 100049, China Department of Respiratory Diseases, Nanfang Hospital, the Southern Medical University, Guangzhou, China. Department of General Surgery 2 The Ninth Hospital of Xi’an Xi'an Shaanxi China Department of Clinical Pharmacology, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine , Shanghai 200233 , China Department of Infectious Diseases, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, China; Hospital Epidemiology and Infection Control, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, China Department of Chemistry, University of WisconsinMadison, 1101 University Avenue, Madison, Wisconsin 53706, and Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, Wisconsin 53226 Department of Clinical Pharmacy, School of Pharmaceutical Sciences, Guizhou Medical University, Guiyang, Guizhou 550025, P.R. China Center of Therapeutic Research for Liver Cancer, Beijing 302 Hospital, Beijing, China; Department of Discovery Chemistry, Bristol-Myers Squibb Research and Development, 5 Research Parkway, Wallingford, Connecticut 06492, United States Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Chengdu, Sichuan 610041, P.R. China Department of Environmental Engineering, School of Metallurgy and Environment, Central South University, Changsha, People’s Republic of China; Chinese National Engineering Research Center for Control & Treatment of Heavy Metal Pollution, Changsha, People’s Republic of China Key Lab of Advanced Energy Storage and Conversion Zhejiang Province Key Lab of Leather Engineering College of Chemistry and Materials Engineering Wenzhou University Wenzhou Zhejiang 325035 P. R. China; Zhejiang Engineering Research Center for Electrochemical Energy Materials and Devices Institute of New Materials and Industrial Technologies Wenzhou University Wenzhou Zhejiang 325035 P. R. China The Chongqing Key Laboratory of Translational Medicine in Major Metabolic Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China; Department of Endocrinology and Nephrology, Chongqing Emergency Medical Center, Chongqing University Central Hospital, Chongqing, China College of Pharmaceutical Science; Zhejiang University of Technology; Hangzhou; China NHC Key Laboratory of Food Safety Risk Assessment, Chinese Academy of Medical Sciences Research Unit (No. 2019RU014), Beijing, P.R. China Department of Neurology, Renmin Hospital Hubei University of Medicine, Shiyan, Hubei Province, People’s Republic of China State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China Key Laboratory of the Ministry of Education for Cell Biology and Tumor Cell Engineering, The School of Life Sciences, Xiamen University, Fujian Province, 361005, China. Center for Research at Bio/Nano Interface, Department of Chemistry, and Department of Physiology and Functional Genomics, Shands Cancer Center, UF Genetics Institute, and McKnight Brain Institute, University of Florida, Gainesville, Florida 32611, United States, State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Biology and College of Chemistry and Chemical Engineering, Hunan University, Changsha, China 410082, and State Key Laboratory for Physical Chemistry of Solid Surfaces, The Key... Department of Retina Center, Affiliated Eye Hospital of Wenzhou Medical University, Hangzhou, Zhejiang Province, China; Anhui University of Chinese Medicine, Hefei 230012, Anhui, China Department of Obstetrics and Gynecology of the Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China. Department of Gastroenterology Second Military Medical University Shanghai China Department of obstetrics and gynecology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China Department of Radiation Oncology, Cooper University Hospital, One Cooper Plaza, Camden, NJ 08103, USA Institute of Botany, Jiangsu Province and Chinese Academy of Sciences, Nanjing 210014, China; Nanjing University of Chinese Medicine, Nanjing 210023, China Xiangya School of Pharmaceutical Sciences, Central South University, Changsha 410013, People’s Republic of China School of Pharmacy Nanjing University of Chinese Medicine Nanjing P. R. China Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine Nanjing China; Jiangsu Province Academy of Traditional Chinese Medicine Nanjing China State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Beijing Key Laboratory of Carcinogenesis and Translational Research, NMPA Key Laboratory for Research and Evaluation of Radiopharmaceuticals (National Medical Products Administration), Department of Nuclear Medicine, Peking University Cancer Hospital & Institute, Beijing 100142, China Institute of Hepatobiliary Surgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, PR China;; Hepatobiliary Surgery Department, 958 Hospital of PLA ARMY, Chongqing, PR China Department of Hematology Affiliated Taihe Hospital of Xi'an Jiaotong University Health Science Center Shiyan China for the InPUT Study Group Department of Chemistry, University of Wisconsin−Madison, 1101 University Avenue, Madison, Wisconsin 53706-1396, and Third Wave Technologies, 502 South Rosa Road, Madison, Wisconsin 53719-1256 Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology; Hubei Province Key Laboratory of Molecular Imaging From the Division of Cardiology, Department of Medicine (K.-H.Y., A.W., L.P., M.-F.C., H.-Y.L., Y.-M.L., Y.C., C.-W.S., C.-P.L., H.-F.T.) and Department of Surgery (K.-Y.S., D.C., W.-K.A.), University of Hong Kong, Queen Mary Hospital, Hong Kong; Research Centre of Heart, Brain, Hormone and Healthy Aging, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong (K.-H.Y., C.W.-S, H.-F.T.); and Department of Medicine, Affiliated Hospital of North Sichuan Medical College, Sichuan, China (L.P.). Second Department of Pediatrics, Affiliated Hospital of Zunyi Medical College, Zunyi 563003, Guizhou Province, China,E-mail: cyz600@ 163.com. Department of Spine Surgery and Guangdong Provincial Key Laboratory of Orthopaedics and Traumatology Sun Yat‐sen University First Affiliated Hospital Guangzhou China State Key Laboratory of Infrared Physics Shanghai Institute of Technical Physics Chinese Academy of Sciences 500 Yu Tian Road Shanghai 200083 China; Frontier Institute of Chip and System Institute of Optoelectronics Shanghai Frontier Base of Intelligent Optoelectronics and Perception Fudan University Shanghai 200433 China Division of Gastroenterology and Hepatology Johns Hopkins University School of Medicine Baltimore MD USA Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences, Shanghai, China. Centre for Medical and Health Sciences, Faculty of Medical and Health Sciences, University of Auckland, Auckland 1010, New Zealand Department of Oral Pathology Peking University School and Hospital of Stomatology, National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology Beijing China Key Laboratory of Proteomics, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences Graduate School, The Chinese Academy of Sciences, Shanghai 200031, China Department of Respiratory and Critical Care Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China; Research Unit of Respiratory Disease, Central South University, Changsha, Hunan, China; Diagnosis and Treatment Center of Respiratory Disease, Central South University, Changsha, Hunan, China BGI PathoGenesis Pharmaceutical Technology Co., Ltd, BGI-Shenzhen, Shenzhen, Guangdong, China; BGI Wuhan Biotechnology, BGI-Shenzhen, Wuhan, Hubei, China 1Department of Gastrointestinal Surgery, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Collaborative Innovation Center for Biotherapy, Chengdu, P.R. China. Department of Hematology, Xiangya Hospital, Central South University, Changsha 410008, China. Department of Respiratory Medicine, The Second Xiangya Hospital, Central-South University, Changsha, Hunan 410011, China; Division of Respiratory Disease, Department of Internal Medicine, The Second Xiangya Hospital, Central-South University, Changsha, Hunan 410011, China Department of Cardiovascular Surgery, Yan’an Hospital Affiliated to Kunming Medical University, No. 245,Renmin East Road, Kunming, Yunnan Province 650051, China Institute of Applied System Analysis, Faculty of Science, Jiangsu University 1 , Zhenjiang, 212013 Jiangsu, China State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China ENT Institute and Otorhinolaryngology Department of Affiliated Eye and ENT Hospital, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai 200031, China; Key Laboratory of Hearing Medicine of NHFPC, Shanghai 200031, China Chinese Academy of Inspection and Quarantine No. A3, Gaobeidian Bei Lu Chaoyang District Beijing 100123 China Departments of Discovery Chemistry, ‡Chemical Synthesis, §Virology, ∥Computer-Assisted Drug Design, and ⊥Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Research and Development, 5 Research Parkway, Wallingford, Connecticut 06492, United States MOE-Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong UniversityShanghai, China; Department of Neonatology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong UniversityShanghai, China. Department of Obstetrics, the Second Affiliated Hospital of Kunming Medical University, Kunming 650101, Yunnan, China. Corresponding author: Wan Linjun, Email: wanlj2003@163.com. National Clinical Research Center for Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease, Fu Wai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100037 , People's Republic of China Department of Respiratory and Critical Care Medicine, The Second Xiangya Hospital; Research Unit of Respiratory Disease; Diagnosis and Treatment Center of Respiratory Disease, Central South University, Changsha, Hunan, China Departments of Radiation Oncology and Deaprtment of Pediatrics, Peking University First Hospital, Beijing 100034, China. Department of Integrated TCM and Western Medicine, Central Hospital of Yiyang City , Yiyang , Hunan, 413200 , China Department of Pediatrics, Affiliated Hospital of Zunyi Medical University, Zunyi 563003, Guizhou Province, China,E-mail：cyz600@ 163.com. Late Stage Pharmaceutical and Processing Development, Early Stage Pharmaceutical Development, and Protein and Analytical Chemistry, Genentech Inc., 1 DNA Way, South San Francisco, California 94080, and Department of Pharmaceutical Chemistry, The University of Kansas, 2095 Constant Avenue, Lawrence, Kansas 66047 Departments of Protein Analytical Chemistry and ‡Biostatistics Genentech, Inc, South San Francisco, California 94080 United States Department of Oncology Zhongda Hospital Southeast University Nanjing P. R. China Laboratory of Autoimmunity Medical College of Xiamen University Xiamen China The Center for Reproductive Medicine, General Hospital of Ningxia Medical University, Yinchuan, China Neutron Sciences Directorate, Oak Ridge National Laboratory, Oak Ridge, TN 37831; Division of Cardiology Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China; Division of Cardiology, Department of Medicine, The University of Hong Kong Shenzhen Hospital, Shenzhen, China Protein Analytical Chemistry, Genentech Inc., South San Francisco, CA, USA. Department of Neonatology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China Department of Endocrinology, Second Hospital of Jilin University, 130041 Changchun, China Department of Respiratory Medicine, The Second Clinical Medical College, Shanxi Medical University, Taiyuan, China Department of Respiratory Medicine, The Second Xiangya Hospital, Central-South University, No. 139 Middle Renmin Road, Changsha, Hunan 410011, China; Division of Respiratory Disease, Department of Internal Medicine, The Second Xiangya Hospital, Central-South University, No. 139 Middle Renmin Road, Changsha, Hunan 410011, China State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center, Chengdu, Sichuan, China. Department of Epidemiology and Health Statistics, Xiangya School of Public Health Central South University Hunan China California Institute of Technology 2 Department of Electrical Engineering, , Pasadena, California 91125, USA Department of Developmental and Stem Cell Biology, Hospital for Sick Children, Toronto, Ontario, Canada.; Institute for Medical Sciences, University of Toronto, Toronto, Ontario, Canada. 5Department of Emergency, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China. 2Analysis Group, Boston, MA State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou 350002, China; School of Environmental and Material Engineering, Yantai University, Yantai 264005, China Department of Protein Analytical Chemistry and §Purification Development, Genentech, Inc., 1 DNA way, South San Francisco, California, 94080-4990, United States Department of General Surgery Huzhou Central Hospital Huzhou China Department of Oncology, Xijing Hospital, Air Force Medical University, No. 169 Changle West Road, Xi’an 710032, China Department of Pathology, Guangdong Medical College, Zhanjiang 524023, P. R. China. Department of Dermatology Hong Kong University Affiliated Shenzhen Hospital Shenzhen Guangdong Province China Children's Hospital of Guizhou Province, Affiliated Hospital of Zunyi Medical University, Zunyi, China Department of Biochemistry, Tufts University School of Medicine and Sackler School of Graduate Biomedical Sciences, Boston, MA Department of Pharmacy, Sichuan Cancer Hospital and Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China Helsinki Rheumatic Diseases and Inflammation Research Group Translational Immunology Research Program University of Helsinki Helsinki University Clinicum Helsinki Finland Department of Gastroenterology Renmin Hospital of Wuhan University Wuhan Hubei 430060 China Joint BioEnergy Institute, Lawrence Berkeley National Laboratory, Emeryville, California 94608, United States; Biological Systems and Engineering, Lawrence Berkeley National Laboratory, Berkeley, California 94710, United States Department of Rehabilitation Medicine, The Affiliated Hospital of Guizhou Medical University, Guiyang, PR China; School of Clinical Medicine, Guizhou Medical University Guiyang, Guiyang, PR China Department of Pediatric Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan China Department of Nephrology, Affiliated Geriatric Hospital, Nanjing Medical University Nanjing China College of Sports and Health, Shandong Sport University, Jinan, China Key Laboratory of Medical Immunology and Department of Laboratory Medicine, Affiliated Hospital of Jiangsu University, Zhenjiang, People's Republic of China. Neutron Scattering Division Oak Ridge National Laboratory Oak Ridge TN 37831 USA Department of Human Anatomy Loma Linda University School of Medicine Loma Linda CA USA Department of Gastroenterology, The 306th Hospital of PLA, Beijing 100101, P.R. China Institute of Human Respiratory Disease Xinqiao Hospital the Army Medical University (Third Military Medical University) Chongqing China School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Cailun Road 1200, Shanghai 201203, China Division of Blood and Marrow Transplantation, Stanford University, Stanford, CA;; Department of Hematology, Central South University Xiangya Hospital, Changsha, China; and Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, China Department of Thoracic Surgery, First Hospital of Tsinghua University, Beijing, P. R. China Jiangsu Cancer Centre, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, The Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, Jiangsu, China Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Key Laboratory for Research and Evaluation of Radiopharmaceuticals (National Medical Products Administration), Department of Nuclear Medicine, Peking University Cancer Hospital and Institute, Beijing 100142, China; Guizhou University School of Medicine, Guiyang, Guizhou 550025, China Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, Liaoning, P. R. China Ministry of Education Key Laboratory of Cell Activities and Stress Adaptations, School of Life Sciences, Lanzhou University, Lanzhou 730000, China Department of Integrative Medicine and Neurobiology, The Academy of Integrative Medicine, School of Basic Medical Sciences, Institutes of Brain Science, Brain Science Collaborative Innovation Center, State Key Laboratory of Medical Neurobiology, Fudan University Department of Pulmonary and Critical Care Medicine, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China School of Materials Science and Engineering Peking University Beijing 100871 China Department of Diagnostic Ultrasound & Echocardiography, Sir Run Run Shaw Hospital, Zhejiang University College of Medicine, Technical Guidance Center for Fetal Echocardiography of Zhejiang Province & Sir Run Run Shaw Institute of Clinical Medicine of Zhejiang University, Hangzhou, China Department of Oral Health Sciences, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, China School of Public Health; University of Alberta; Edmonton Alberta Canada Departments of Pharmacology and Vascular Cell Signaling and Therapeutics Program, Boyer Center for Molecular Medicine, and Medicine and Cardiovasculate Gene Therapy Program, Yale University School of Medicine, New Haven, CT 06536; and Department of Pathology, Dartmouth Medical School, Lebanon, NH 03756 The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, Center for Information in Medicine, School of Life Science and Technology University of Electronic Science and Technology of China Chengdu People's Republic of China School of Applied Physics and Materials, Wuyi University, Jiangmen 529020, P. R. China National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University; Key Laboratory for Molecular Enzymology and Engineering, the Ministry of Education, School of Life Sciences, Jilin University Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, and School of Public Health, University of Alberta, Edmonton, AB, Canada Department of Pathology, West China College of Stomatology, Sichuan University, Chengdu 610041, China. Department of Clinical Laboratory, Shanghai Tenth People’s Hospital of Tongji University, Middle Yanchang Road, Shanghai, China Laboratory of Molecular Biology and Bovine Breeding, Institute of Animal Sciences Chinese Academy of Agricultural Sciences Beijing China Department of Dermatology Peking University First Hospital Beijing China; National Clinical Research Center for Skin and Immune Diseases Beijing China; Beijing Key Laboratory of Molecular Diagnosis on Dermatoses Beijing China; National Medical Products Administration Key Laboratory for Quality Control and Evaluation of Cosmetics Beijing China State Key Laboratory of Microbial Technology, Shandong University, Jinan 250100, P. R. China Key Laboratory of Southwestern Chinese Medicine Resources School of Pharmacy, Chengdu University of Traditional Chinese Medicine Chengdu China Division of Cardiology, Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China Clinical Laboratory Department of Fujian Tumor Hospital, Fujian Medical University, Fuzhou 350014, China; Email: yanc99@sina.com. Hainan Provincial Center for Disease Control and Prevention Japan Guangdong Key Laboratory for Research and Development of Natural Drugs, Bone Biology Laboratory, Guangdong Medical College, Zhanjiang 524023, China. chyang@gdmc.edu.cn Department of Pediatrics, Xinhua Hospital, School of Medicine Shanghai Jiao Tong University Shanghai China State Key Laboratory of Animal Biotech Breeding, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing 100193, China State Key Lab of Inorganic Synthesis and Preparative Chemistry, Jilin University, Changchun 130012, Jilin, China Frontier Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering (Ministry of Education), School of Chemical Engineering and Technology, Tianjin University, Tianjin, People’s Republic of China; Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin University, Tianjin, People’s Republic of China From the Veterans Affairs Medical Center, Iowa City, IA; and the Departments of Internal Medicine and Physiology and Biophysics, University of Iowa College of Medicine, Iowa City, IA. The State Key Laboratory of Functions and Applications of Medicinal Plants Guizhou Medical University Guizhou China; The High Efficacy Application of Natural Medicinal Resources Engineering Center of Guizhou Province School of Pharmaceutical Sciences Guizhou Medical University Guizhou China; The Union Key Laboratory of Guiyang City‐Guizhou Medical University School of Pharmaceutical Sciences Guizhou Medical University Guizhou China Department of Pathology, Cancer Hospital, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China. Department of Public Health, Shenyang Medical College, Liaoning, China Department of Oncology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing 210009, China Department of Respiratory Medicine, The Second Hospital of Shanxi Medical University, Taiyuan, China Department of Clinical Laboratory Beijing Chest Hospital Capital Medical University Beijing China Laboratory of Biochemistry and Molecular Biology Research, Fujian Provincial Key Laboratory of Tumor Biotherapy, Department of Clinical Laboratory, Fujian Cancer Hospital and Fujian Medical University Cancer Hospital, Fuzhou, Fujian, China Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China; University of the Chinese Academy of Sciences, Shanghai, China Institute of Plant Quarantine, Chinese Academy of Inspection and Quarantine, Beijing 100176, China Department of Gastroenterology, The Second Affiliated Hospital, College of Medicine Zhejiang University , Hangzhou , China Thermo Fisher Scientific, 95134, San Jose, CA, USA School of Chemistry and Chemical Engineering, and Shanghai Key Laboratory of Electrical Insulation and Thermal Aging, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, P. R. China Department of Infectious Disease, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, The People’s Republic of China; Hubei Province Key Laboratory of Molecular Imaging, Wuhan, The People’s Republic of China From St. Jude Children's Research Hospital, Memphis, Tennessee; Fred Hutchinson Cancer Research Center, Seattle, Washington; University of Alberta, Edmonton, Alberta, Canada; The University of Texas MD Anderson Cancer Center, Houston, Texas; University of Minnesota Medical School, Minneapolis, Minnesota; University of Chicago, Chicago, Illinois; David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, California;; Memorial Sloan Kettering Cancer Center, New York, New York; Emory University, Atlanta, Georgia; and The Hospital for Sick Children, Toronto, Ontario, Canada. Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA National Clinical Research Center for Metabolic Diseases, Key Laboratory of Diabetes Immunology (Central South University), Ministry of Education, and Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China Zhoushan Center for Disease Control and Prevention, ZhoushanChina Department of Orthopaedics, Affiliated Pingyang Hospital and School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang 325000, China State Key Laboratory of Artificial Microstructure and Mesoscopic Physics School of Physics Peking University Beijing 100871 P. R. China Department of Pathogen Biology and Immunology, Jiangsu Key Laboratory of Immunity and Metabolism, Jiangsu International Laboratory of Immunity and Metabolism, Xuzhou Medical University, Xuzhou, Jiangsu 221004, China Department of Critical Care Medicine, Shengli Oilfield Center Hospital, Dongying, Shandong 257000, P.R. China Department of Respiratory and Critical Care Medicine, the Second Xiangya Hospital, Central South University, Changsha, Hunan, China; Research Unit of Respiratory Disease, Central South University, Changsha, Hunan, China; Diagnosis and Treatment Center of Respiratory Disease, Central South University, Changsha, Hunan, China; Clinical Medical Research Center for Respiratory and Critical Care Medicine in Hunan Province, China Engineering Research Center of Oral Translational Medicine Ministry of Education National Engineering Laboratory for Oral Regenerative Medicine State Key Laboratory of Oral Diseases National Clinical Research Center for Oral Diseases Department of Oral and Maxillofacial Surgery West China Hospital of Stomatology Sichuan University Chengdu 610041 P. R. China Jiangsu Key Laboratory of Carcinogenesis and Intervention; State Key Laboratory of Natural Medicines; JiangSu Key Laboratory of Drug Design and Optimization; Key Laboratory of Drug Quality Control and Pharmacovigilance; Ministry of Education; China Pharmaceutical University; Nanjing People's Republic of China Blood Center of Zhejiang Province, Hangzhou, Zhejiang 310052, China Department of Anesthesiology The Second Affiliated Hospital of Zhengzhou University Zhengzhou China Key Laboratory of Mechanism Theory and Equipment Design of Ministry of Education, Tianjin University, 135 Yaguan Road, Tianjin 300350, China; School of Mechanical Engineering, Tianjin University, 135 Yaguan Road, Tianjin 300350, China Department of Ultrasound, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, China China-Japan Friendship Hospital, Beijing 100029, China Key Laboratory of Nutrition and Metabolism Institute for Nutritional Sciences Shanghai Institutes for Biological Sciences Chinese Academy of Sciences University of Chinese Academy of Sciences Shanghai China Departments of aCell Biology Research Center of Laser Fusion, China Academy of Engineering Physics, Mianyang 621900, China. chenyan19870123@126.com Department of Gerontology West China Hospital, Sichuan University Chengdu China Department of Blood Transfusion, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China. Pfizer Inc, Collegeville, PA, USA. CAS Key Laboratory of Quantum Information, University of Science and Technology of China , Hefei 230026, China and , Hefei 230026, China; CAS Center for Excellence in Quantum Information and Quantum Physics, University of Science and Technology of China , Hefei 230026, China and , Hefei 230026, China Virology Group, Veterinary Infectious Disease Organization, University of Saskatchewan, Saskatoon, Saskatchewan, Canada S7N 5E3,1 and Centre for Medical and Health Sciences Education, School of Medicine, University of Auckland, Auckland, New Zealand Departments of aSurgery, Department of Pharmacy, Zhejiang Provincial Key Laboratory of Biometrology and Inspection & Quarantine, College of Life Sciences, China Jiliang University, Hangzhou, 310018, China Department of Pediatrics, Affiliated Hospital of Zunyi Medical University, Zunyi 563003, Guizhou Province, China. E-mail: cyz600@163.com. Department of Chemistry, Department of Physiology and Functional Genomics and Department of Material Sciences and Engineering, Center for Research at Bio/nano Interface, Shands Cancer Center, University of Florida, Gainesville, Florida 32611-7200; Molecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Bio-Sensing and Chemometrics, College of Biology, College of Chemistry and Chemical Engineering; and State Key Laboratory of Advanced Design and Manufacture for Vehicle Body, College of Mechanical and Automotive Engineering, Hunan University, Changsha 410082, People’s Republic of China Chongqing Institute of Green and Intelligent Technology, Chinese Academy of Sciences, Chongqing 400714, China; University of Chinese Academy of Sciences, Beijing 100049, China Department of Pharmacology, School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, People's Republic of China, and South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, People's Republic of China Schizophrenia Program, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai Key Laboratory of Psychotic Disorders, Shanghai, China; Innovative Research Team of High-level Local Universities in Shanghai College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China. Department of Emergency, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China Neutron Scattering Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831, United States Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada Department of General Surgery and Laparoscopic Center, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, P.R. China School of Life Sciences, Yunnan University, Kunming, Yunnan 650091, P.R. China Department of Ophthalmology and Visual Sciences, University of Texas Medical Branch, Galveston, Texas, United States National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun 130012, China; Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, School of Life Sciences, Jilin University, Changchun 130012, China; NMPA Key Laboratory of Humanized Animal Models for Evaluation of Vaccines and Cell Therapy Products, Jilin University, Changchun 130012, China Department of Gynecologic Endocrine Jinan Maternity and Child Care Hospital Jinan 250001 People's Republic of China Department of Clinical Laboratory Shanghai Tenth People’s Hospital, Tongji University School of Medicine Shanghai China Department of Respiratory Disease, Nanfang Hospital, South Medical University, Guangzhou 510515, China. Department of Zoology, College of Life Science, Sichuan Agricultural University, Ya'an, Sichuan 625014, China Department of Clinical Pharmacology Xiangya Hospital Central South University Changsha P. R. China; Hunan Key Laboratory of Pharmacogenetics Institute of Clinical Pharmacology Central South University Changsha P. R. China; Engineering Research Center of Applied Technology of Pharmacogenomics Ministry of Education Changsha P. R. China; National Clinical Research Center for Geriatric Disorders Changsha P. R. China Joint BioEnergy Institute, 5885 Hollis Street, Emeryville, California 94608, United States; Biological Systems & Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States School of Chemistry and Chemical Technology, State Key Laboratory for Composite Materials, Shanghai Jiao Tong University, Shanghai 200240, People's Republic of China Department of Parasitology, Guiyang Medical College, Guiyang 550004. Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, UK. yanc0913@gmail.com. Key Laboratory of Combinatory Biosynthesis and Drug Discovery (Ministry of Education), School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China Department of Gastroenterology, Changhai Hospital, Naval Medical University, No. 168 Changhai Road, Shanghai 200433, China Comprehensive Liver Cancer Department, The Fifth Medical Center of the Chinese PLA General Hospital, Beijing, P.R. China Tanz Centre for Research in Neurodegenerative Diseases University of Toronto Toronto Canada State Key Laboratory of Biotherapy and Cancer Center,West China Hospital,and West China School of Basic Medical Sciences & Forensic Medicine,Sichuan University, and Collaborative Innovation Center for Biotherapy,Chengdu,China Department of Respiratory and Critical Care Medicine The Second Hospital of Shanxi Medical University Taiyuan P. R. China Department of Gastroenterology, Weifang Yidu Central Hospital, Weifang, Shandong, China. Department of Anesthesiology, Zhuzhou Central Hospital, Zhuzhou Hunan 412007,China. Center for Medical Genetics & Hunan Key Laboratory of Medical Genetics School of Life Sciences Central South University Hunan China Department of Anorectal Surgery, Huzhou Central Hospital, Huzhou, Zhejiang, China (mainland) Second Department of Pediatrics，Affiliated Hospital of Zunyi Medical College/The Children's Hospital of Guizhou Province，Zunyi 563003，Guizhou Province， China.E-mail: cyz600@ 163.com. Protein Analytical Chemistry, Genentech, South San Francisco, California 94080, United States Department of Cardiology, Zhengzhou University People's Hospital, Zhengzhou 450001, China Department of Zoology, College of Life Science, Sichuan Agricultural University, Ya’an, Sichuan, China School of Art Design and Media, East China University of Science and Technology, Shanghai 200030, China Department of Neonatology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China Technology Division, Joint Bioenergy Institute, Emeryville, CA 94608; Sport Science Research Center, Beijing Sport University, Bejing, China MediQuest Therapeutics, Inc., 22322 20th Avenue S.E., Bothell, Washington 98021, and Lankenau Institute for Medical Research, 100 Lancaster Avenue, Wynnewood, Pennsylvania 19096 Department of Public Health Sciences, University of Alberta, Edmonton, Alberta, Canada Department of Cardiology, Yongchuan Hospital of Chongqing Medical University, Chongqing, China (mainland) College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, China Department of Stomatology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China College of Biology & Pharmacy Yulin Normal University Yulin PR China Department of Anesthesiology, The First Affiliated Hospital of Kunming Medical University, Kunming, China Laboratory of Anti-Inflammatory and Immunomodulatory Pharmacology, Innovation Program of Drug Research on Inflammatory and Immune Diseases, Southern Medical University, Guangzhou 510515, China; NMPA Key Laboratory for Research and Evaluation of Drug Metabolism, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China Department of Traditional Chinese Medicine, School of Pharmacy, Anhui Medical University, Hefei 230032, China; School of Chemistry, Sun Yat-sen University, Guangzhou 510275, China Department of Colorectal Surgery Huzhou Central Hospital Zhejiang China School of Life Sciences, The University of Chinese Academy of Sciences, Beijing, China State Key Laboratory of Inorganic Synthesis and Preparative Chemistry; College of Chemistry; Jilin University; Changchun 130012, P. R. China Blood Center of Shandong Province, Jinan, Shandong 250014, China. sdhla@aliyun.com. Key Laboratory of Functional Polymer Materials of Ministry of Education; College of Chemistry; Collaborative Innovation Center of Chemical Science and Engineering (Tianjin); Nankai University; Tianjin 300071 Department of Anesthesiology, Southwest Hospital, Third Military Medical University, Chongqing, China Joint Laboratory of Plasma Application Technology, Institute of Advanced Technology, University of Science and Technology of China, Hefei 230026, China Key Laboratory of Systems Bioengineering (Ministry of Education); Tianjin University; Tianjin; P. R. China; SynBio Research Platform Department of Medicine, Institute of Clinical Medicine; Helsinki University Central Hospital; Helsinki Finland Department of Pediatrics, Affiliated Hospital of Zunyi Medical college, Zunyi 563003, Guizhou Province, China.E-mail: cyz600@163.com. Department of Cardiology, Tianjin Chest Hospital, Tianjin 300200, China ; Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China. Department of General Surgery, Daqing Oilfield General Hospital, Daqing, Heilongjiang 163000, P.R. China Department of Neurology, Weihai Municipal Second Hospital, Weihai City The State Key Laboratory of Chemical Oncogenomics, Key Laboratory of Chemical Biology, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, P.R. China National Clinical Research Center for Metabolic Diseases Key Laboratory of Diabetes Immunology (Central South University), Ministry of Education, and Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University Changsha Hunan China Department of Biochemistry and Molecular Biology, School of Basic Medicine, Xinjiang Medical University, Xinjiang, China School of Applied Physics and Materials, Wuyi University, Jiangmen, 529000, China Department of Gastroenterology The 306th Hospital of PLA Beijing China Department of Pathology, Georgetown University School of Medicine, Washington, D.C. 20007,1 and The State Engineering Laboratory of AIDS Vaccine, Jilin University Department of Ultrasound, Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University), Haikou, Hainan, China (mainland) Research and Development, Bristol-Myers Squibb, 5 Research Parkway, Wallingford, Connecticut 06492, United States Joint Laboratory of Green Synthetic Chemistry, Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, China Department of Respiratory and Critical Care Medicine, the Second Xiangya Hospital, Central South University, Changsha, China; Research Unit of Respiratory Disease, Central South University, Changsha, China; Diagnosis and Treatment Center of Respiratory Disease, Central South University, Changsha, China Center for Research at Bio/nano Interface, Department of Chemistry and Department of Physiology and Functional Genomics, Shands Cancer Center, UF Genetics Institute and McKnight Brain Institute, University of Florida, Gainesville, Florida 32611-7200, United States,; State Key Laboratory of Chemo/Bio-Sensing and Chemometrics, College of Biology and College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, People's Republic of China Division of Paediatric Surgery, Department of Surgery, Li Ka Shing Faculty of Medicine, The University of Hong Kong , China Key Laboratory of Hui Ethnic Medicine Modernization of Ministry of Education, Ningxia Medical University, Yinchuan, China School of Life Sciences, Anhui University, Hefei 230601, P. R. China Department of Gastroenterology, the Second Affiliated Hospital, School of Medicine, Zhejiang University , Zhejiang , China College of Landscape Architecture and Forestry, Qingdao Agricultural University, Qingdao 266109, China; Forestry College, Inner Mongolia Agricultural University, Hohhot 010018, China College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, P.R. China Center for Research at Bio/Nano Interface, Department of Chemistry and Department of Physiology and Functional Genomics, Shands Cancer Center, UF Genetics Institute and McKnight Brain Institute, University of Florida, Gainesville, Florida 32611, United States; State Key Laboratory of Chemo/Bio-Sensing and Chemometrics, College of Biology and College of Chemistry and Chemical Engineering, College of Biology, Hunan University, Changsha, 410082, P. R. China Bio Therapeutics Development, Janssen Research & Development, LLC, Malvern, PA, USA Hainan Provincial Center for Disease Control and Prevention Center for Therapeutic Research of Hepatocarcinoma,Beijing 302 Hospital,Beijing,China School of Environmental Ecology and Biological Engineering Wuhan Institute of Technology Wuhan China Ecological Security and Protection Key laboratory of Sichuan Province College of Life Science and Biotechnology Mianyang Normal University Mianyang Sichuan 621000 China State Key Laboratory of Natural Medicines China Pharmaceutical University Nanjing 210009 China The National and Local Joint Engineering Laboratory of Animal Peptide Drug Development, College of Life Sciences, Hunan Normal University, Changsha 410081, China Department of Pediatrics; Affiliated Hospital of Zunyi Medical University; Zunyi 563003; PR China School of Life Sciences, Anhui University, Hefei, Anhui, China Ecological Security and Protection Key laboratory of Sichuan Province Mianyang Normal University Mianyang Sichuan 621000 China Department of Diagnostic Imaging National Cancer Center National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China Multicomponent of Traditional Chinese Medicine and Microecology Research Center, Jiangsu Provincial Academy of Chinese Medicine, Nanjing, China and Biological Systems and Engineering, Lawrence Berkeley National Laboratory , Berkeley, CA, USA Department of Endocrinology and Nephrology, Chongqing University Central Hospital, Chongqing Emergency Medical Center, China Applied Molecular Diagnostic Group, On-Q-ity, Inc., Waltham, MA, USA Department of Rehabilitation Medicine, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510260, P.R. China State Key Laboratory of Chemical Oncogenomics, Key Laboratory of Chemical Biology, Tsinghua Shenzhen International Graduate School, Shenzhen, Guangdong, China 1Novartis Institutes for BioMedical Research, Cambridge, Massachusetts. State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou 350002, China; School of Physical Science and Technology, Shanghai Tech University, Shanghai 201210, China; University of Chinese Academy of Sciences, Beijing 100049, China; Shanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai 201210, China Shanghai Veterinary Research Institute, the Chinese Academy of Agricultural Sciences, 518 Ziyue Road, Shanghai 200241, PR China Department of Respiration Medicine, Zhongshan Hospital of Xiamen University, P.R. China Department of Gastroenterology, The Second Affiliated Hospital of Chengdu Medical College, China National Nuclear Corporation 416 Hospital, Chengdu, Sichuan, China. Experimental Teaching Center, College of Food Science and Engineering, Jilin University, Changchun 130062, China Department of Chemistry and Department of Physiology and Functional Genomics, Shands Cancer Center and Center for Research at the Interface of Bio/Nano, UF Genetics Institute and McKnight Brain Institute, University of Florida, Gainesville, Florida 32611-7200, United States; Molecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Bio-Sensing and Chemometrics, College of Biology and College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, People's Republic of China Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment Collaborative Innovation Center For Cancer Personalized Medicine Nanjing Medical University Nanjing China; Department of Biochemistry and Molecular Biology Nanjing Medical University Nanjing China Department of Immunology School of Basic Medical Sciences Capital Medical University Beijing China Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390; and Departments of aPharmacology and Department of Cardiology, Ezhou Central Hospital, Ezhou, Hubei 436000, P.R. China Institute for Integrative Nanosciences Leibniz IFW Dresden Helmholtzstrasse 20 01069 Dresden Germany Department of Pulmonary and Critical Care Medicine, Zhongshan Hospital, Xiamen University, Teaching Hospital of Fujian Medical University, Xiamen, Fujian Province, People’s Republic of China Department of Cardiology The Affiliated Wuxi People's Hospital of Nanjing Medical University Wuxi China NHC Key Laboratory of Food Safety Risk Assessment, Chinese Academy of Medical Science Research Unit (No. 2019RU014), China National Center for Food Safety Risk Assessment, Beijing 100021, P.R. China Department of Epilepsy Surgery, Shenzhen Children's Hospital, Shenzhen, Guangdong, China Department of Pediatrics Peking University First Hospital Beijing China Department of Oncology, Zhongda Hospital, Medical School, Southeast University, Nanjing 210009, China College of Food Science and Technology, Henan University of Technology, Zhengzhou 450001, P. R. China Department of Chemical Physics, University of Science and Technology of China, Hefei 230026, China Center of Burn & Plastic and Wound Healing Surgery, Hengyang Medical School, The First Affiliated Hospital University of South China Hengyang China State Key Laboratory of Precision Measuring Technology and Instruments, Tianjin University, Tianjin 300072, China Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences , Shanghai , PR China Department of Pediatrics, Affiliated Hospital of Zunyi Medical University, Zunyi, People’s Republic of China; Department of Pediatrics, Guizhou Children's Hospital, Guiyang, People’s Republic of China; Collaborative Innovation Center for Tissue Injury Repair and Regenerative Medicine, Zunyi Medical University, Zunyi, People’s Republic of China Research Associate College of Food Science, South China Agricultural University, 483 Wushan Road, Guangzhou 510642, China; Guangdong Laboratory for Lingnan Modern Agriculture, South China Agricultural University, 483 Wushan Road, Guangzhou, 510642, China School of Computer Science Southwest Petroleum University Chengdu Sichuan China; Research Center for Smart Oil and Gas Field Southwest Petroleum University Chengdu Sichuan China Department of Infection, Immunity and Cardiovascular Disease Medical School University of Sheffield UK Center for Cell Structure and Function, Shandong Provincial Key Laboratory of Animal Resistance Biology, Collaborative Innovation Center of Cell Biology in Universities of Shandong, College of Life Sciences, Shandong Normal University, Jinan 250014, China Department of Neonatal Medicine Xin‐Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai China College of Education Science, Nantong University, Nantong , P.R. China Clinical Pharmacology Institute Nanchang University Nanchang P. R. China Medical School of Southeast University Nanjing China Department of Marine BiologyInstitute of Evolution and Marine Biodiversity, Ocean University of ChinaQingdaoChina Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China Emergency Center, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province; Department of Cardiology, Kizilsu Kirghiz Autonomous Prefecture People's Hospital, Artux, P.R. China. Department of Cardiorenal Cerebrovascular Medicine, Kagawa University School of Medicine Department of Gynecology The Second Affiliated Hospital of Nanjing University of Chinese Medicine Nanjing Jiangsu China The Second Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, China College of Pharmacology Sciences, Zhejiang University of Technology, Hangzhou 310014, P. R. China School of Mathematics and Physics, North China Electric Power University, Beinong Road 2, Huilongguan, Beijing 102206, P. R. China; School of New Energy, North China Electric Power University, Beinong Road 2, Huilongguan, Beijing 102206, P. R. China Department of Dermatology, Yangjiang Hospital Affiliated of Guangdong Medical University, Yangjiang, 529500 Guangdong, China Department of Respiratory Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China (mainland) Department of Neonatology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China. Electronic address: chenyan01@xinhuamed.com.cn. Joint BioEnergy Institute Emeryville California; Biological Systems and Engineering Division Lawrence Berkeley National Laboratory Berkeley California Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States Zhejiang Medical University, China. Plant Gene Engineering Center, Chinese Academy of Sciences Key Laboratory of South China Agricultural Plant Molecular Analysis and Genetic Improvement, Guangdong Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, China; University of Chinese Academy of Sciences, Beijing 100049, China State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences (CAAS), Harbin, People's Republic of China State Key Laboratory of Infrared Physics, Shanghai Institute of Technical Physics, Chinese Academy of Sciences, 500 Yu Tian Road, Shanghai 200083, China; University of Chinese Academy of Sciences, 19 Yuquan Road, Beijing 100049, China Department of Urology, The Second Affiliated Hospital of Kunming Medical University , 374 Burma Avenue , Kunming 650101 , China Sino−German Joint Research Institute, State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang, Jiangxi 330047, People’s Republic of China Department of Biological Sciences, Virginia Tech, Blacksburg, Virginia, USA Department of Biological Sciences, Columbia University, New York, NY 10027 Department of Biochemistry, Uppsala University, SE-75123 Uppsala, Sweden, and Departments of Medicine and Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 Center for Inflammatory Bowel Diseases The Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou China Anhui Provincial Hospital, China Laboratory of Biochemistry and Molecular Biology Research Fujian Cancer Hospital Fuzhou China; Department of Clinical Laboratory Fujian Cancer Hospital & Fujian Medical University Cancer Hospital Fuzhou China 1Department of Pathology, UT Southwestern Medical Center, Dallas, Texas. Guangzhou Women and Children's Medical Center; Guangzhou China; Department of Surgery; the University of Hong Kong; Hong Kong SAR China Department of Psychiatry, Zhejiang Chinese Medical University, China Department of Hand Surgery One, The Puai Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, P.R. China Departments of †Medicinal Chemistry, ‡Pharmacology, §Drug Metabolism and Pharmacokinetics, and ∥Molecular and Cellular Biology, Theravance Biopharma, Inc., 901 Gateway Boulevard, South San Francisco, California 94080, United States School of Environment and Energy National Engineering Laboratory for VOCs Pollution Control Technology and Equipment South China University of Technology Guangzhou 510000 China Department of Chemistry and Center for Diagnostics and Therapeutics, Georgia State University, P.O. Box 4098, Atlanta, Georgia 30303, United States Institute of Occupational Medicine, Chinese Academy of Preventive Medicine, Beijing 100050, China. Wuya College of Innovation Shenyang Pharmaceutical University Shenyang China Department of Cardiology, Henan Provincial Key Lab For Control of Coronary Heart Disease, Heart Center of Henan Provincial People's Hospital, Central China Fuwai Hospital Central China Fuwai Hospital of Zhengzhou University Zhengzhou China School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, China Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, Changsha, China Obstetrics Department, International Peace Maternity & Child Health Hospital, Shanghai Jiaotong University, Shanghai, China and Division of Cardiology Department of Medicine Li Ka Shing Faculty of Medicine The University of Hong Kong Hong Kong SAR China Department of Nephrology The Affiliated Jiangyin Hospital of Southeast University Medical College Jiangyin China Biomedical Engineering Center and State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan University, Changsha, Hunan, China. Department of Ophthalmology Johns Hopkins University School of Medicine Baltimore MD USA Department of Cell Biology and of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX, USA Collaborative Innovation Center of Modern Bio-Manufacture Anhui University, Hefei 230601, People’s Republic of China Department of Pathology, UT Southwestern Medical Center, Dallas, TX 75390, USA Henan Province Engineering Research Center of High Value Utilization to Natural Medical Resource in Yellow River Basin, School of Pharmacy, Henan University, Kaifeng 475004, China Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, and Graduate School of the Chinese Academy of Sciences, Shanghai 200031, China. Key Laboratory for Biomedical Engineering of Ministry of Education , Center for Brain Imaging Science and Technology, College of Biomedical Engineering and Instrument Sciences, , Hangzhou 310027 , China; Zhejiang University , Center for Brain Imaging Science and Technology, College of Biomedical Engineering and Instrument Sciences, , Hangzhou 310027 , China Department of Gastroenterology, PLA Strategic Support Force Characteristic Medical Center, Beijing, P. R. China College of Data Science and Information Engineering, Guizhou Minzu University, Guiyang, Guizhou Province Hubei Provincial Key Laboratory for Protection and Application of Special Plant Germplasm in Wuling Area of China Key Laboratory of State Ethnic Affairs Commission for Biological Technology College of Life Sciences South‐Central University for Nationalities Wuhan China Key Laboratory for Photonic and Electronic Bandgap Materials Ministry of Education School of Physics and Electronic Engineering Harbin Normal University Harbin 150025 China School of Mathematics and Physics North China Electric Power University Beinong Road 2, Huilongguan Beijing 102206 P. R. China; Institute of Clusters and Low Dimensional Nanomaterials North China Electric Power University Beinong Road 2, Huilongguan Beijing 102206 P. R. China; School of New Energy North China Electric Power University Beinong Road 2, Huilongguan Beijing 102206 P. R. China Beijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing University of Chemical Technology, Beijing 100029, P. R. China Cell Biology Department, NYU School of Medicine, New York, NY 10016,USA. Department of Physiology, Luzhou Medical College, Luzhou 646000, China. Department of Gastroenterology, Second Military Medical University/Naval Medical University, Shanghai, China Key Laboratory for Organic Electronics and Information Displays & Institute of Advanced Materials; Jiangsu National Synergetic Innovation Center for Advanced Materials; Nanjing University of Posts & Telecommunications; Nanjing 210023; China The High Educational Key Laboratory of Guizhou Province for Natural Medicinal Pharmacology and Druggability, Guizhou Medical University, Huaxi university town, Guian new district 550025, Guizhou, People’s Republic of China; Department of Pharmacology of Chinese Material Medica, Guizhou Medical University, Huaxi university town, Guian new district 550025, Guizhou, People’s Republic of China Institute of Rocket Force Medicine, State Key Laboratory of Trauma, Burns and Combined Injury, College of Preventive Medicine, Third Military Medical University (Army Medical University), Chongqing 400038, China. School of Chemistry and Materials Science, Jiangsu Normal University, Xuzhou, Jiangsu 221116, China Department of Ophthalmology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China. Department of Endocrine Laboratory, Anhui Provincial Hospital Affiliated to Anhui Medical University, Hefei, Anhui 230001, China Guangdong Provincial Key Laboratory of Orthopaedics and Traumatology, Orthopaedic Research Institute/Department of Spinal Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China Department of Ophthalmology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai 200233, China Department of Pediatrics, Jining No. 1 People's Hospital, Jining, Shandong 272011, P.R. China Department of Cardiology, Fuwai Central China Cardiovascular Hospital, Zhengzhou, China. Department of Metabolism and Endocrinology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China; Key Laboratory of Diabetes Immunology (Central South University), Ministry of Education, National Clinical Research Center for Metabolic Diseases, Changsha, Hunan, China Department of Antibody Discovery and Protein Engineering, MedImmune, Gaithersburg, MD, USA Department of Hematology, The affiliated hospital of Southwest Medical University, Luzhou, Sichuan, China Eric J. Chow Fred Hutchinson Cancer Research Center, University of Washington, Seattle, WA; Yan Chen, University of Alberta, Edmonton, Alberta, Canada; Melissa M. Hudson, Daniel M. Green, Daniel A. Mulrooney, Kirsten K. Ness, Leslie L. Robison, Gregory T. Armstrong, and Yutaka Yasui, St Jude Children’s Research Hospital; Daniel A. Mulrooney, University of Tennessee, Memphis, TN; Elizabeth A.M. Feijen, Leontien C. Kremer, Cécile M. Ronckers, Helena J. van der Pal, and Irma W.E.M. van Dijk, Emma Children’s... Department of Pediatric, The Affiliated Hospital of Zunyi Medical College/The Children's Hospital of Guizhou Province, Zunyi 563003,Guizhou Province, China. E-mial:cyz600@163.com. State Key Laboratory of Fine Chemicals Frontier Science Center for Smart Material School of Chemical Engineering Dalian University of Technology Linggong Road 2 Dalian 116024 China Department of Geriatric Medicine, Shandong Provincial Third Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong Province, China Hainan Center for Disease Control and Prevention Haikou Hainan 570203 China Department of Electroencephalogram Room, Shenzhen Children’s Hospital, Shenzhen, Guangdong, China Department of Gynecology and Obstetrics, The Affiliated Hospital of North Sichuan Medical College, Nanchong, China Department of Neurosurgery, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China Department of Physiology, Luzhou Medical College, Luzhou 646000, Sichuan Province, China. College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, P. R. China; Laboratory Animal Center, Zhejiang University of Technology, Hangzhou, P. R. China. Laboratory of Pediatric Hematology， Wuhan Children's Hospital， Tongji Medical College， Huazhong University of Science ＆ Technology, Wuhan 430016， Hubei Province， China. NHC Key Laboratory of Food Safety Risk Assessment, Chinese Academy of Medical Science Research Unit (No. 2019RU014), China National Center for Food Safety Risk Assessment No. 7 Panjiayuan Nanli, Beijing Chaoyang 100021 China Department of Opthalmology, Dean McGee Eye Institute, University of Oklahoma Health Sciences Center , Oklahoma City, Oklahoma 73104, USA Department of Clinical Laboratory, Shanghai Tenth People's Hospital, Tongji University, Shanghai 200072, China Department of Ophthalmology Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai China Taihe Hospital Shiyan Hubei Province, China Jiangsu Health Vocational College; China Department of General Medicine, Panyu Central Hospital, Guangzhou, China. Department of Critical Care Medicine, Shengli Oilfield Central Hospital, Dongying, Shandong, China (mainland) Department of Pharmaceutical Sciences, Second Military Medical University, 325 Guohe Road, Shanghai 200433, China From the Departments of Anaesthesia and Intensive Care (X.L., Y.T., Z.M., Y.C., I.H.T.H., T.G., W.K.K.W., M.T.V.C.) and Obstetrics and Gynaecology (K.W.C.), The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong Special Administrative Region, People’s Republic of China; Institute of Human Genetics, Helmholtz Zentrum München, Neuherberg, Germany (P.L.); Institute of Digestive Dis Key Laboratory of Thrombosis and Hemostasis of Ministry of Health Jiangsu Institute of Hematology The First Affiliated Hospital of Soochow University Soochow China Department of Epidemiology, University of Washington, Seattle, Washington;; Kidney Research Institute, Seattle, Washington; State Key Laboratory of Natural Medicines, School of Basic Medical Sciences and Clinical Pharmacy, China Pharmaceutical University, Nanjing 210009, Jiangsu, China Laboratory of Molecular Diagnostics, College of Pharmaceutical Sciences, Soochow University, Suzhou, China. Institute of Hematology & Oncology, Beijing Aerospace General Hospital, Beijing 100076, China; The Second Department of Pediatrics, Affiliated Hospital of Zunyi Medical College, Zunyi 563003, Guizhou Province, China. Department of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology School of Electrical Engineering, Zhengzhou University, Zhengzhou, China School of Perfume and Aroma Technology, Shanghai Institute of Technology, Shanghai 201418, P. R. China Department of Pathology, UT Southwestern Medical Center, Dallas, Texas, USA School of Life Science; Anhui University; Hefei 230039; China Hunan Provincial Key Laboratory of Xiangnan Rare-Precious Metals Compounds Research and Application, School of Physics and Electronic Electrical Engineering, Xiangnan University, Chenzhou 423000, P. R. China Guangdong Key Laboratory for R&D of Natural Drug Department of Pharmacology Marine Biomedical Research Institute Guangdong Medical University Zhanjiang China Department of Cardiopulmonary Bypass Chinese Academy of Medical Science and Peking Union Medical College Fuwai Hospital and National Center for Cardiovascular Diseases Beijing China; Anesthesia and Operation Center Chinese PLA General Hospital Beijing China Department of Neurology Nantong Third People's Hospital, Nantong University Nantong Jiangsu China School of Petroleum Engineering, Yangtze University, Wuhan 434100, China Ecological Security and Protection Key Laboratory of Sichuan Province Mianyang Normal University Sichuan 621000 China Paediatric Urodynamic Center and Department of Urology; Institute of Clinical Medicine; The First Affiliated Hospital of Zhengzhou University; Zhengzhou China Key Laboratory for Anisotropy and Texture of Materials (Ministry of Education); School of Material Science and Engineering; Northeastern University; Shenyang 110819; China Joint Laboratory of Reproductive Medicine, SCU-CUHK, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, P.R. China Department of Physical Examination, Ningbo First hospital, Ningbo, Zhejiang, China Clayton Foundation Laboratories for Peptide Biology Salk Institute for Biological Studies La Jolla, California 92037 Division of Thyroid Surgery China‐Japan Union Hospital of Jilin University, Jilin Provincial Key Laboratory of Surgical Translational Medicine, Jilin Provincial Precision Medicine Laboratory of Molecular Biology and Translational Medicine on Differentiated Thyroid Carcinoma Changchun China Hainan Provincial Center for Disease Control and Prevention, Haikou 570203, China First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China Xinjiang Medical University. Email: ychen88@sina.com. Division of Cardiology, Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China; Division of Cardiology, Department of Medicine, The University of Hong Kong Shenzhen Hospital, ShenZhen, China Department of Gastroenterology, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China College of Bioscience and Biotechnology, Crop Gene Engineering Key Laboratory of Hunan Province, Hunan Agricultural University, Changsha 410128, China State Key Laboratory of Organic Electronics and Information Displays & Jiangsu Key Laboratory for Biosensors, Institute of Advanced Materials (IAM), Nanjing University of Posts & Telecommunications, 9 Wenyuan Road, Nanjing 210023, China bSchool of Public Health, Wannan Medical College, Wuhu, China State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150001, People’s Republic of China Department of Geratology Shanghai People's Armed Police Corps Hospital Shanghai China Shantou University Medical College, Shantou, Guangdong, China. Institute of Pharmacology, College of Pharmaceutical Sciences Zhejiang Chinese Medical University Hangzhou Zhejiang 311402 China Department of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China Key Laboratory of Advanced Functional Materials, Education Ministry of China, Beijing University of Technology, Beijing 100124, China Department of Ophthalmology and Visual SciencesUniversity of Texas Medical BranchGalvestonTexasUSA Borough of Manhattan Community College, New York, NY; Department of General Surgery, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China. Department of Pathogen Biology, Medical College, Nantong University, Nantong, Jiangsu 226001, P.R. China College of Physical Science and Technology, Central South University, Changsha 410083, China. Department of Zoology, College of Life Science, Sichuan Agricultural University, Ya’an, Sichuan 625014, China Department of Nephrology The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University Wenzhou China College of Materials & Environmental Engineering, Hangzhou Dianzi University, Hangzhou, 310018, P. R. China College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, P. R. China Department of Radiology, Union Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan China Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, China Departrment of Gastroenterology, The 2nd Hospital of Zhejiang University China. Anhui University of Chinese Medicine, Hefei 230031, Anhui, China Department of Imaging Diagnosis, National Cancer Center/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China Second Affiliated Hopsital, University of South China, Hengyang 421001, China. China Key Laboratory of Pest Monitoring and Green Management, MOA, and College of Plant Protection China Agricultural University Beijing China School of Life Science and Technology, Nanyang Normal University,Nanyang 473061, Henan, China. National Laboratory for Infrared Physics, Shanghai Institute of Technical Physics, Chinese Academy of Sciences, Shanghai 200083, China State Key Laboratory of Biotherapy/Geriatrics and Cancer Center, West China Hospital, and Collaborative Innovation Center for Biotherapy, Sichuan University, Chengdu 610041, China Guangdong Key Laboratory for Research and Development of Natural Drugs, Guangdong Medical University, Zhanjiang, Guangdong 524023, P.R. China Key Laboratory of Cancer Proteomics of Chinese Ministry of Health, Xiangya Hospital, Central South University, Changsha 410008, China The School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China Fujian Oncology Hospital, Fuzhou 350014, China. yanc99@sina.com Department of Ultrasound, Shenzhen Hospital, Southern Medical University, Shen Zhen, China; Division of Cardiology, Department of Medicine, The University of Hong Kong Shen Zhen Hospital, Shen Zhen, China; Division of Cardiology, Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China Regional Medical Center for National Institute of Respiratory Diseases, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, PR China; Key Laboratory of Microbial Technology and Bioinformatics of Zhejiang Province, Hangzhou, PR China; Department of Infectious Disease, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, PR China School of Chemistry and Chemical Engineering, Shanghai Jiaotong University, 800 Dongchuan Lu, Shanghai 200240, China, and Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, China Department of Neurology, The First Affiliated Hospital of China Medical University, Shenyang, China Department of Pathology, The Third Xiangya Hospital of Central South University, Changsha, Hunan, China College of Materials and Environmental Engineering, Hangzhou Dianzi University, Hangzhou 310018, People’s Republic of China Division of Nephrology, Department of Medicine, University of Washington, Kidney Research Institute, Seattle, Washington;; Department of Epidemiology, University of Washington, Seattle Washington; and School of Pharmacy CHIRI WABRI Curtin University Perth Western Australia Department of Medicine, Melbourne Health and Northern Health, The University of Melbourne, Melbourne, Australia Department of Pharmacy, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Center, Sichuan Cancer Hospital and Institute, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu, China. Department of Nephrology, Affiliated Hospital of Jiangnan University Wuxi 214125, Jiangsu Province, China. Department of Hepatology, Fifth Medical Center of Chinese PLA General Hospital, Beijing, China; CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China; University of Chinese Academy of Sciences, Beijing, China; Department of Genetic Identification, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands; China National Center for Bioinformation, Beijing, China. Department of Pharmacology of Materia Medica, School of Pharmaceutical Sciences, Guizhou Medical University, Guizhou 550025, China Department of Infection, Immunity & Cardiovascular Disease, Medical School, and; Bateson Centre, University of Sheffield, Sheffield, United Kingdom Institute for Integrative Nanosciences IFW Dresden Helmholtzstraße 20 01069 Dresden Germany Department of Mental Health, Shenzhen Nanshan Center for Chronic Disease Control, ShenZhen, China Center of Inflammatory Bowel Disease, Department of Gastroenterology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China Department of School Health, Zhoushan Municipal Center for Disease Control and Prevention, Zhoushan, Zhejiang, China Department of Chemistry and Department of Physiology and Functional Genomics, Shands Cancer Center and UF Genetics Institute, Center for Research at the Bio/Nano Interface, McKnight Brain Institute, University of Florida, Gainesville, FL 32611-7200;; State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Biology, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China; and Guangdong Institute of Intelligence Science and Technology, 519031 Zhuhai, China; Research Unit of Pain Medicine, Chinese Academy of Medical Sciences; SIMR Joint Lab of Drug Innovation, Shanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai, 201210 China Department of Cardiology No.971 Hospital of the PLA Navy Qingdao Shandong China Department of Neurology, Wuhan Fourth Hospital, Puai Hospital, Tongji Medical College, Huazhong University of Science and Technology, China Department of Anaesthesiology, Southwest Hospital Third Military Medical University (Army Medical University) 30 Gaotanyan Road Chongqing China National Engineering Laboratory for AIDS Vaccine, College of Life Science, Jilin University BMCC, CUNY, New York, NY. International Business School, Hunan University of Technology and Business, Changsha, China Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, 200031, China; School of Life Sciences and Technology, Shanghai Tech University, Shanghai, 200031, China National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention/State Key Laboratory for Infectious Disease Prevention and Control/National Reference Laboratory of Tuberculosis, Beijing, China; Pathogenic Biology Institute, University of South China, Hengyang, Hunan, China Department of Internal Medicine, South Branch of Fujian Provincial Hospital, Fuzhou, Fujian Province, China; Provincial Clinic Medical College, Fujian Medical University, Fuzhou, Fujian Province, China; Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong Province, China Clayton Foundation Laboratories for Peptide Biology, The Salk Institute, La Jolla, CA 92037 State Key Laboratory for Strength and Vibration of Mechanical Structures, School of Aerospace, Xi’an Jiaotong University, Xi’an, 710049, P. R. China Department of Respiratory, The Second Hospital of Shanxi Medical University, Taiyuan, China National Clinical Research Center for Metabolic Diseases, Key Laboratory of Diabetes Immunology (Central South University), Ministry of Education, and Department of Metabolism and Endocrinology The Second Xiangya Hospital of Central South University Changsha Hunan China Department of Obstetrics and Gynecology, North China University of Science and Technology Affiliated Hospital, Tangshan, Hebei 063000, P.R. China School of Life Sciences; Anhui University; Hefei; China; Key Laboratory of Modern Biomanufacturing of Anhui Province Department of Psychology, Peking University, No. 5 Yiheyuan Road, Haidian District, Beijing 100871, China; Capital Institute of Pediatrics, Beijing 100020, China Eric J. Chow and Norman E. Breslow, Fred Hutchinson Cancer Research Center, Seattle Children's Hospital, University of Washington, Seattle, WA; Yan Chen and Yutaka Yasui, University of Alberta, Edmonton, Alberta, Canada; Leontien C. Kremer, Elizabeth A.M. Feijen, and Helena J. van der Pal, Emma Children's Hospital and Academic Medical Center, Amsterdam, the Netherlands; Melissa M. Hudson, Gregory T. Armstrong, Daniel M. Green, Daniel A. Mulrooney, Kirsten K. Ness, and Leslie L. Robison, St Jude... State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210023, P. R. China Institute of Quality Standard and Monitoring Technology for Agro-products of Guangdong Academy of Agricultural Sciences, Guangdong Provincial Key Laboratory of Quality & Safety Risk Assessment for Agro-products, and Key Laboratory of Testing and Evaluation for Agro-product Safety and Quality (Guangzhou), Ministry of Agriculture and Rural Affairs, Guangzhou 510640, China Department of Cardiology Henan Provincial People's Hospital Zhengzhou China; Department of Cardiology Zhengzhou University People's Hospital Zhengzhou China; Department of Cardiology Fuwai Central China Cardiovascular Hospital Zhengzhou China Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences , Shanghai , China National Engineering Laboratory for AIDS Vaccine, School of Life Sciences Jilin University Changchun 130012 China; Key Laboratory for Molecular Enzymology and Engineering, The Ministry of Education, School of Life Sciences Jilin University Changchun 130012 China Center For Research at the Bio/nano Interface, Department of Chemistry and Department of Physiology and Functional Genomics, Shands Cancer Center, University of Florida, Gainesville, Florida 32611-7200, United States; State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Biology, College of Chemistry and Chemical Engineering, Hunan University, Changsha, Hunan 410082, People’s Republic of China Department of Radiology, China-Japan Friendship Hospital, Beijing, China School of Nursing, Southwest Medical University, Luzhou 646000, Sichuan Province, China,Department of Pediatric, Sichuan Provincial People's Hospital, Sichuan Academy of Medical Sciences, Chengdu 610072, Sichuan Province, China. Department of Pharmacology, Shantou University Medical College, Shantou 515041, China Princess Margaret Cancer Centre/Ontario Cancer Institute, University Health Network, Toronto, Canada 1 The Biomedical Translational Research Institute, Faculty of Medical Science, Jinan University, Guangzhou, People’s Republic of China; Guangdong Provincial Key Laboratory of Tumor Interventional Diagnosis and Treatment, Zhuhai Institute of Translational Medicine, Zhuhai People’s Hospital Affiliated with Jinan University, Jinan University, Zhuhai, People’s Republic of China People's Hospital of Juan Cheng County Shandong Province China Center for Molecular Medicine, Xiangya Hospital, Central South University, Changsha, China 410008 Laboratory of Anti‐inflammatory and Immunomodulatory Pharmacology, Innovation Program of Drug Research on Inflammatory and Immune Diseases, NMPA Key Laboratory for Research and Evaluation of Drug Metabolism & Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences Southern Medical University Guangzhou China Tumor Institute of Yunnan Province, the Third Affiliated Hospital of Kunming Medical University (Tumor Hospital of Yunnan Province) Department of Electrocardiology, Haining People’s Hospital, Zhejiang Province, China Department of Gynecology and Obstetrics, Key Laboratory of Obstetric and Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu 610041, P.R. China; Department of Gynecology and Obstetrics, Chengdu First People’s Hospital, Chengdu 610041, P.R. China ‡Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202 Department of Biomedical Engineering, School of Basic Medical Science, Wuhan University, Wuhan, China; Research Center for Medicine, Wuhan University, Wuhan, China Institute of Molecular Engineering and Applied Chemistry, Anhui University of Technology, No. 59 Hudong Road, Ma’anshan, Anhui 243002, China Environment Functional Materials Division Shenyang National Laboratory for Materials Science Institute of Metal Research Chinese Academy of Sciences Shenyang Liaoning Province 110016 PR China; University of Chinese Academy of Sciences Beijing 100049 PR China National Engineering Laboratory for AIDS Vaccine School of Life Sciences, Jilin University Changchun 130012 China; Key Laboratory for Molecular Enzymology and Engineering the Ministry of Education, School of Life Sciences, Jilin University Changchun 130012 China Analysis Group, 333 South Hope Street, 27th Floor, Los Angeles, CA 90071, USA Department of General Surgery, Changzhou Wujin People’s Hospital, Changzhou, Jiangsu, China; Wujin Clinical College, Xuzhou Medical University, Changzhou, Jiangsu, China State Key Laboratory of Infrared Physics Shanghai Institute of Technical Physics Chinese Academy of Sciences 500 Yu Tian Road Shanghai 200083 China; Frontier Institute of Chip and System Institute of Optoelectronics Shanghai Frontier Base of Intelligent Optoelectronics and Perception Fudan University Shanghai 200438 China Department of Spine Surgery and Musculoskeletal Tumor, Zhongnan Hospital of Wuhan University, No. 169, Donghu Road, Wuhan City 430071, Hubei Province, P. R. China Department of Pharmacy, Sichuan Cancer Hospital and Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China; College of Agriculture and Bioengineering, Heze University, Heze, Shandong, China Xiamen‐Borstel Joint Laboratory of Autoimmunity Medical College of Xiamen University Xiamen China Division of Cardiology, Department of Medicine, Queen Mary Hospital, The University of Hong Kong, China College of Chemical and Pharmaceutical Engineering Jilin Institute of Chemical Technology Jilin China Shanghai Frontiers Science Research Base of Intelligent Optoelectronics and Perception, Institute of Optoelectronics, Fudan University, Shanghai 200433, China; Shanghai Institute of Technical Physics, Chinese Academy of Sciences, Shanghai 20083, China Second Department of Pediatrics, Zunyi Medical University, Affiliated Hospital of Zunyi Medical University, The Children's Hospital of Guizhou Province, Zunyi 563003, Guizhou Province, China,E-mail: cyz600@163.com. Institute of Botany, Jiangsu Province and Chinese Academy of Sciences, Nanjing 210014, China State Key Laboratory of Infrared Physics, Shanghai Institute of Technical Physics, Chinese Academy of Sciences, 500 Yu Tian Road, Shanghai 200083, China. Ministry of Education Key Laboratory of Bioinorganic and Synthetic Chemistry, State Key Laboratory of Optoelectronic Materials and Technologies, KLGHEI of Environment and Energy Chemistry, School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou, Guangdong 510275, P.R. China Department of Orthopaedics, Pu Ai Hospital of Tongji Medical College, Huazhong University of Science and Technology, 473 Hanzheng Street, Qiaokou District, Wuhan 430030, China Department of Materials Science State Key Laboratory of Molecular Engineering of Polymers Fudan University 220 Handan Road Shanghai 200433 P. R. China Vaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, Oregon, USA Institute of Crop Science, Chinese Academy of Agricultural Sciences , Beijing 100081, China; Hainan Yazhou Bay Seed Laboratory , Sanya 572025, China Department of Respiratory and Critical Care Medicine, Second Xiangya Hospital Central South University Changsha China; Research Unit of Respiratory Disease Central South University Changsha China; Diagnosis and Treatment Center of Respiratory Disease Central South University Changsha China Department of Radiology, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, No. 222, West Huanhu 3 Road, 201306 Shanghai, China Elekta (Shanghai) Instrument Ltd, China School of Mechanical Engineering, Tianjin University, 92 Weijin Road, Nankai District, Tianjin 300072, China. Department of Clinical Medicine, College of Medicine, Jiaxing University, Jiaxing, Zhejiang, PR China. Department of Laboratory Diagnosis, Changhai Hospital, Second Military Medical University, 168 Changhai Road, Shanghai 200433, China Department of Neurology, Nantong Third People’s Hospital, Affiliated Nantong Hospital 3 of Nantong University , Nantong, Jiangsu , China Department of Pulmonary and Critical Care Medicine, Second Xiangya Hospital, Central South University, Changsha 410011, China. chenyan99727@csu.edu.cn. Institute of Public Health, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China; Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China Molecular and Cellular Developmental Biology Laboratory, Harbin Institute of Technology, Harbin 150001, China. Department of Medical and Molecular Genetics, Walther Oncology Center, Indiana University School of Medicine and the Walther Cancer Institute, Indianapolis, IN 46202, U.S.A.; Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China for the Chinese Acute Pancreatitis Clinical Trials Group (CAPCTG) Email: drchenyixin@hotmail.com. the Second Clinical Medical College, Guangzhou University of Chinese Medicine Guangzhou 510000, China. Department of Oral pathology Peking University School and Hospital of Stomatology & National Center of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices & Beijing Key Laboratory of Digital Stomatology & Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health & NMPA Key Laboratory for Dental Materials Beijing China Division of Engineering, King’s College London, Strand, London WC2R 2LS, United Kingdom Department of Hematology, The First Clinical Hospital of Jilin Province Academy of Traditional Chinese MedicineJilin, China. College of Life Science, Zhejiang Chinese Medical University, Hangzhou 310053, China 2University of Alberta, Edmonton, Alberta, Canada. Department of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang 212013, PR China School of Chemistry Sun Yat-Sen University Guangzhou 510275 P. R. China; School of Marine Sciences Sun Yat-Sen University Guangzhou 510006 P. R. China Key Laboratory of Modern Preparation of TCM, Ministry of Education Jiangxi University of Traditional Chinese Medicine Nanchang China School of Public Health, Wannan Medical College, Wuhu 241002 China. 2313449765@qq.com. Department of Ultrasound, Fujian Maternity and Child Health Hospital, Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, P.R. China School of Public Health, Wannan Medical College. Wuhu,Anhui 241002 China.. yingshuiyao@163.com. Department of Endocrinology, Wuwei People’s Hospital, Wuwei, Gansu Province, China Department of Cardiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China; Department of Internal Medicine, Tianjin Hospital, Tianjin, China Key Laboratory of Green Synthesis and Preparative Chemistry of Advanced Materials, Liaoning University, Shenyang 110036, China Drug Discovery Department, Moffitt Cancer Center, Tampa, Florida 33612, United States Chinese medicine department, Songnan Town Community Health Service Center, Shanghai, China Xinjiang Key Laboratory for Uighur Medicine, Institute of Materia Medica of Xinjiang, Urumqi 830004, China Key Laboratory of Functional Molecular Engineering of Guangdong Province, School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, P. R. China State Key Laboratory of Infrared Physics, Shanghai Institute of Technical Physics, Chinese Academy of Sciences, 500 Yutian Road, Shanghai 200083, China; Shanghai Key Laboratory of Multidimensional Information Processing, School of Communication and Electronic Engineering, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China Department of Plastic & Reconstructive Surgery, Center for Plastic & Reconstructive Surgery Zhejiang Provincial People's Hospital (Affiliated People's Hospital, Hangzhou Medical College) Hangzhou China Institute for Nutrition and Food Safety, Chinese Center for Disease Control and Prevention, Beijing 100021, China. yan_chen2000@yahoo.com.cn Department of Pathology Taizhou People's Hospital Taizhou China Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, Huazhong Agricultural University, Wuhan 430070, China; Hubei Hongshan Laboratory, Wuhan 430070, China; The Cooperative Innovation Center for Sustainable Pig Production, Huazhong Agricultural University, Wuhan 430070, China Department of Neonatology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China Department of Pharmacy, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu, China; School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China. Department of Chemistry, University of Nebraska-Lincoln, Lincoln, Nebraska, 68588, USA Guangxi Colleges and Universities Key Laboratory of Natural and Biomedical Polymer Materials, College of Materials Science and Engineering, Guilin University of Technology, Guilin 541004, China Department of Traditional Chinese Medicine, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510080, China Department of Cardiology Henan Provincial People's Hospital Zhengzhou Henan China Department of Neurology Zhongnan Hospital, Wuhan University Wuhan China Joint BioEnergy Institute, Emeryville, California, USA School of Traditional Chinese Medicine, Shenyang Pharmaceutical University College of Pharmaceutical Science Zhejiang University of Technology Hangzhou China Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China School of Pharmacy, Nanjing University of Chinese Medicine , No. 138 Xianlin Avenue, Nanjing 210023, China; Department of Science and Technology, Taizhou Hospital Affiliated to Nanjing University of Chinese Medicine , No. 86 Jichuan East Road, Taizhou 225300, China Medical Intensive Care Unit, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China Department of Stomatology, Hospital Affiliated to Inner Mongolia Medical University, Huhhot, 010110. College of Food Science and Technology, Henan University of Technology, Zhengzhou 450001, People’s Republic of China Department of Ultrasound, Peking University Shenzhen Hospital, Shenzhen Key Laboratory for Drug Addiction and Medication Safety, Institute of Ultrasound Medicine, Shenzhen-PKU-HKUST Medical Center, Shenzhen, 518036, China The Ministry-Province Jointly Constructed Base for State Key Lab - Shenzhen Key Laboratory of Chemical Biology, the Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, P. R. China; Shenzhen Technology and Engineering Laboratory for Personalized Cancer Diagnostics and Therapeutics, Shenzhen Kivita Innovative Drug Discovery Institute, Shenzhen 518055, P. R. China Department of Gastroenterology, Changhai Hospital Second Military Medical University Shanghai China; Digestive Endoscopy Center, Changhai Hospital Second Military Medical University Shanghai China Key Laboratory of Geriatrics of Jiangsu Province, Department of Geriatrics, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu, China National Engineering Research Center of Light Alloy Net Forming, State Key Laboratory of Metal Matrix Composites, Shanghai Jiao Tong University, Shanghai 200240, P. R. China China National Center for Food Safety Risk Assessment, Chaoyang, Beijing, P.R. China University of Toronto NHC Key Laboratory of Food Safety Risk Assessment, Chinese Academy of Medical Science Research Unit, China National Center for Food Safety Risk Assessment, Beijing 100021, P. R. China Sports Coaching College, Beijing Sport University , Beijing , China School of Mechanical Engineering, Tianjin University, Tianjin 300072, China; Key Laboratory of Mechanism Theory and Equipment Design of Ministry of Education, Tianjin University, Tianjin 300072, China Department of Respiratory Liwan Hospital of Guangzhou Medical University Guangzhou Guangdong 510170 China Biogical Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States; Joint BioEnegy Institute, Emeryville, California 94608, United States Key Laboratory of Luminescence Analysis and Molecular Sensing (Southwest University), Ministry of Education, School of Materials and Energy, Southwest University, Chongqing 400715, China WuXi AppTec, 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131, China Gregory T. Armstrong, Daniel A. Mulrooney, and Leslie L. Robison, St. Jude Children's Research Hospital, Memphis, TN; Kevin C. Oeffinger and Charles A. Sklar, Memorial Sloan-Kettering Cancer Center, New York, NY; Yan Chen and Yutaka Yasui, University of Alberta, Edmonton, Alberta, Canada; Toana Kawashima, Wendy Leisenring, and Eric J. Chow, Fred Hutchinson Cancer Research Center; Eric J. Chow, Seattle Children's Hospital, Seattle, WA; Marilyn Stovall and Jean-Bernard Durand, The University of Texas MD... CHINALLERGY Biotech Co., Ltd., Wuhan Institute of Biotechnology, 666 Gaoxin Road, Wuhan 430079, China Joint BioEnergy Institute (JBEI) Emeryville California; Biological Systems and Engineering Division Lawrence Berkeley National Laboratory Berkeley California Zhejiang Provincial Engineering Technology Research Center of Marine Biomedical Products, School of Food and Pharmacy, Zhejiang Ocean University, Zhoushan 316022, China Laboratory of Biochemistry and Molecular Biology Research, Department of Clinical Laboratory, Fujian Provincial Key Laboratory of Tumor Biotherapy, Fujian Cancer Hospital and Fujian Medical University Cancer Hospital, Fuzhou, Fujian 350014, P.R. China Affiliated Hospital of Zunyi Medical University/Guizhou Provincial Children's Hospital, Zunyi, China Department of Medical Care for Cadres, Zhejiang Hospital, Hangzhou, China. School of Life Sciences, Zhejiang Chinese Medical University , No. 548 Binwen Road, Binjiang District , Hangzhou 310053 , China Department of Infectious Diseases, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China; Key Laboratory of Microbial Technology and Bioinformatics of Zhejiang Province, Hangzhou, China Chemical and Engineering Materials Division, Neutron Sciences Directorate, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831, United States Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Graduate School of the Chinese Academy of Sciences, 294 Taiyuan Road, Shanghai 200031, China Department of Cardiology Tianjin Medical University General Hospital Tianjin China School of Chemistry and Chemical Engineering, Zhongkai University of Agriculture and Engineering, Guangzhou, China College of Public Health, Xinjiang Medical University, Ulumuqi 830054, China. Department of Gastroenterology, Affiliated Hospital of Binzhou Medical University, Shandong Province, China Department of Pharmacology, University of Michigan Medical School , Ann Arbor, MI 48109 , USA Division in Signaling Biology, Research Institute, Princess Margaret Cancer Center University Health Network Toronto M5G 1L7 Canada Department of Respiratory and Critical Care Medicine, the Second Xiangya Hospital, Central South University, Changsha, Hunan, China; Research Unit of Respiratory Disease, Central South University, Changsha, Hunan, China; Diagnosis and Treatment Center of Respiratory Disease, Central South University, Changsha, Hunan, China Departments of Medicine and Pharmacology & Toxicology, University of Louisville School of Medicine, and Jewish Hospital Heart and Lung Institute, Louisville, Kentucky 40202 Department of Pathology, Jiangsu Cancer Hospital, Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, Jiangsu, China Protein Science Laboratory of the Ministry of Education, School of Life Sciences, Tsinghua University, Beijing 100084, China State Key Laboratory of Veterinary Biotechnology Chinese Academy of Agricultural Sciences (CAAS) Harbin Veterinary Research Institute Harbin People's Republic of China Section of Endocrinology, Yale University, New Haven, Connecticut 06520; Fred Hutchinson Cancer Research Center (K.C.), Seattle, Washington 98104 Hammond Research Station, Agricultural Center, Louisiana State University, Hammond, LA The National and Local Joint Engineering Laboratory of Animal Peptide Drug Development College of Life Sciences Hunan Normal University Changsha Hunan China Department of Cardiology Tangdu Hospital The Fourth Military Medical University Xi'an 710038 China; Department of Emergency Chinese PLA No.401 Hospital Qingdao 266071 China Department of Emergency, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, PR China University of Nottingham, School of Medicine, Translational Medical Sciences, Nottingham Tongji Hospital Affiliated to Tongji University, Shanghai, China Otorhinolaryngology Department of The Affiliated Eye and ENT Hospital, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, PR China; Central Laboratory, Affiliated Eye and ENT Hospital of Fudan University, Shanghai, PR China; Key Laboratory of Hearing Medicine of The National Health and Family Planning Commission, Shanghai, PR China Department of Gastrointestinal and Anal Surgery, The First Hospital of Jilin University, Changchun, China International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China Department of Chemistry Shanghai Key Lab of Molecular Catalysis and Innovative Materials, and State Key Laboratory of Molecular Engineering of Polymers Fudan University Shanghai 200433 P. R. China Departments of Pharmacology, Medicine, and Pathology and Mass Spectrometry Research Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-6602 Department of Endocrinology the Second Hospital of Jilin University Changchun Jilin China Department of Gynecologic Endocrine, Ji'nan Maternity and Child Care Hospital, Ji'nan 250001, China. Department of Pharmaceutics School of Pharmacy, Nantong University Nantong China National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention/State Key Laboratory for Infectious Disease Prevention and Control, Beijing, China; Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou, China; Pathogenic Biology Institute, University of South China, Hengyang, Hunan Province, China Jiangsu Institute of Hematology, National Clinical Research Center for Hematologic Diseases, NHC Key Laboratory of Thrombosis and Hemostasis, Department of Haematology The First Affiliated Hospital of Soochow University Soochow University Suzhou Jiangsu People's Republic of China; Division of Haematolgy Institute of Blood and Marrow Transplantation, Collaborative Innovation Center of Hematology Soochow University Suzhou People's Republic of China Elekta Instrument Ltd. Beijing Branch Shanghai China Department of General Surgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province 215006, China Department of Respiratory Medicine, Respiratory Disease Research Institute, The Second Xiangya Hospital, Central South University, Changsha, China Faculty of Liver Disease of Chinese PLA General Hospital The Fifth Medical of Chinese PLA General Hospital Beijing China Department of Infectious Diseases, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, China; Key Laboratory of Microorganism Technology and Bioinformatics Research of Zhejiang Province, Hangzhou, Zhejiang Province, China Department of Pediatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China School of Mechanical Engineering Wuhan Polytechnic University Wuhan China Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, Beichen West Road 1-104, Chaoyang, Beijing, 100101, PR China; University of Chinese Academy of Sciences, 19 Yuquan Road, Shijingshan, Beijing, 100049, PR China. Department of Cardiology Tianjin Chest Hospital Tianjin China The LOVIT-COVID Investigators, on behalf of the Canadian Critical Care Trials Group, and the REMAP-CAP Investigators Department of Infectious Diseases, Taizhou Hospital of Zhejiang Province, Wenzhou Medical University, Linhai, Zhejiang, China Department of Anesthesiology, Children’s Hospital of Hebei Province, No.133, Jianhua South Avenue, Yuhua District, Shijiazhuang, Hebei 050071, P.R. China State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou 350002, People’s Republic of China; University of Chinese Academy of Sciences, Beijing 100049, People’s Republic of China; School of Physical Science and Technology, ShanghaiTech University, Shanghai 201210, People’s Republic of China Department of Chemistry and Department of Physiology and Functional Genomics, Center for Research at the Bio/Nano Interface, Shands Cancer Center, UF Genetics Institute and McKnight Brain Institute University of Florida, Gainesville, Florida 32611-7200, United States; State Key Laboratory for Chemo/Biosensing and Chemometrics, College of Biology and College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, People’s Republic of China Department of Respiratory Medicine, The Second Xiangya Hospital of Central-South University, Hunan, Changsha, China; ENT Institute and Otorhinolaryngology Department, Affiliated Eye and ENT Hospital, Fudan University, Shanghai, China. NHC Key Laboratory of Hearing Medicine (Fudan University), Shanghai Engineering Research Centre of Cochlear Implant, Shanghai, China. College of Fisheries and Life Science, Hainan Tropical Ocean University, Sanya, PR China All authors: Johns Hopkins University School of Medicine, Baltimore, MD. School of Medicine, Yangzhou Polytechnic College, Yangzhou, Jiangsu 225009, China School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 210000, China Department of Pediatric Critical Care, Guizhou Provincial Children’s Hospital, Zunyi, Guizhou, China. Center for Inflammatory Bowel Diseases, Department of Gastroenterology, the Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou China Anhui University of Chinese Medicine, Hefei, 230012 Anhui, China Department of General Practice, Wuhu City Second People`s Hospital, Wuhu City, Anhui Province, People’s Republic of China. School of Physics and Astronomy, University of Minnesota, Minneapolis, Minnesota, USA. Department of Liver Disease, the Fifth Medical Center of Chinese PLA General Hospital, Beijing, China Department of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China. State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan Agricultural University, Kunming 650201, China; College of Plant Protection, Yunnan Agricultural University, Kunming 650201, China University of Science and Technology of China School of Life Sciences, Anhui University, Hefei, Anhui 230601, P.R. China Division of nutrition Jiangsu Cancer Hospital and Jiangsu Institute of Cancer Research and Nanjing Medical University Affiliated Cancer Hospital Nanjing China Division of Cardiology Department of Medicine The University of Hong Kong Shenzhen Hospital Shenzhen China; Division of Cardiology Department of Medicine The University of Hong KongQueen Mary Hospital Hong Kong China Department of Nursing, Nanjing Hospital Affiliated to Nanjing University of Traditional Chinese Medicine Nanjing, Jiangsu Province, China. ENT Institute and Otorhinolaryngology Department of Affiliated Eye and ENT Hospital, Key Laboratory of Hearing Medicine of NHFPC, Shanghai Engineering Research Centre of Cochlear Implant, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, China; Key Laboratory of Genetics and Germplasm Innovation of Tropical Special Forest Trees and Ornamental Plants, College of Forestry, Hainan University, Haikou, Hainan, China Graduate School of Nanjing University of Chinese Medicine, Nanjing, China Department of Medicine, Acute Lung Injury Center of Excellence, University of Pittsburgh, Pittsburgh, PA 15213, USA. Jiangsu Institute of Hematology, National Clinical Research Center for Hematologic Diseases, NHC Key Laboratory of Thrombosis and Hemostasis The First Affiliated Hospital of Soochow University, Soochow University Suzhou P.R China State Key Laboratory of Soil and Sustainable Agriculture, Institute of Soil Science, Chinese Academy of Sciences, Nanjing, China Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China 5University of Alberta School of Public Health, Department of Public Health Sciences, Edmonton, Alberta, Canada. National Engineering Research Center of Chiral Drugs, Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041, China; Innovation Research Center of Chiral Drugs, Institute for Advanced Study, Chengdu University, Chengdu 610106, China; University of Chinese Academy of Sciences, Beijing 100049, China Department of Pediatrics, The Affiliated Hospital of Zunyi Medical University, Guizhou Children's Hospital, Zunyi 563000, Guizhou Province, China,E-mail: cyz600@163.com. Key Laboratory of Gastrointestinal Cancer (Fujian Medical University), Ministry of Education, Fuzhou, China Department of Neurology, Changshu Hospital of Xuzhou Medical University, Changshu Second People's Hospital, Changshu 215501, Jiangsu, China. Engineering Research Center of Oral Translational Medicine, Ministry of Education, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.; National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.; State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.; National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.; Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China. Arizona State University, Mesa, AZ, USA Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China. Department of Infectious Diseases, Sir Run Run Shaw Hospital; Department of Hospital Epidemiology and Infection Control, Sir Run Run Shaw Hospital Bachelor of Nursing, Director of Nursing Department of Nanjing Drum Tower Hospital, Nursing Department, Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School Jiangsu China Department of Metabolism and Endocrinology The Second Xiangya Hospital of Central South University National Clinical Research Center for Metabolic Diseases Key Laboratory of Diabetes Immunology (Central South University) Ministry of Education Changsha Hunan China College of Chemistry and Biological Engineering, Yichun University, Yichun, Jiangxi, China Department of Traditional Chinese Medicine, Yidu Central Hospital of Weifang State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, P. R. China; University of Chinese Academy of Sciences, Beijing, 100039, P. R. China State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Carcinogenesis and Intervention, China Pharmaceutical University, Nanjing, People’s Republic of China; and Department of Clinical Oncology, Xijing Hospital, Air Force Medical University, Xi’an 710032, China Key Laboratory of Pesticide & Chemical Biology of Ministry of Education, International Joint Research Center for Intelligent Biosensor Technology and Health of Ministry of Science and Technology, Central China Normal University, Wuhan 430079, People’s Republic of China Department of Gynecology and Obstetrics North China University of Science and Technology Affiliated Hospital Tangshan China Department of Pharmaceutical Sciences, Shenyang Pharmaceutical University, Shenyang 110016, P.R. China the First Affiliated Hospital of Chongqing Medical University School of Chemistry and Chemical Engineering, Xuzhou Institute of Technology School of Sociology and Anthropology Xiamen University Xiamen China Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai, China Department of Pathology, Jiangsu Cancer Hospital, Nanjing, China Department of Geriatric Healthcare Unit 5, Anhui Provincial Hospital, Hefei, Anhui, China (mainland) School of Bioengineering, Dalian University of Technology, Dalian, People’s Republic of China Department of Endocrinology The Second Hospital of Jilin University Changchun China 4School of Public Health, University of Alberta, Edmonton, Alberta, Canada. Innovation Team of Cattle Genetics and Breeding, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing, China Department of Radiology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China.chenyan_me@163.com. Department of Respiratory and Critical Care Medicine, General Hospital of Northern Theater Command, Shenyang, PR China Department of Gynecology, Wuxi Yihe Maternity Hospital, Wuxi, Jiangsu Province, China yan_chen0822@163.com. College of Chemistry and Chemical Engineering, Liaocheng University, Liaocheng 252000, P. R. China Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. Department of Pediatrics Jining No.1 People's Hospital Jining China Department of Pediatrics, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China. Neurology Department, Shanghai Jiahui International Hospital, Shanghai, China State Key Laboratory of Quality Research in Chinese Medicine and Institute of Chinese Medical Sciences, University of Macau, Macau Department of Ultrasound First Affiliated Hospital College of Medicine Zhejiang University Hangzhou China National Engineering Laboratory for AIDS Vaccine College of Life Science, Jilin University Changchun Jilin Province 130012 People's Republic of China Division in Signaling Biology Princess Margaret Cancer Center University Health Network Toronto Canada Department of Public Health Science, University of Alberta Edmonton Alberta Canada School of Life Sciences, Nantong University, Nantong, Jiangsu 226019, P.R. China. School of Life Sciences, Anhui University, Hefei, Anhui 230601, China Department of Chemistry and Department of Surgery, The University of Hong Kong, Pokfulam Road, Hong Kong, P.R. China Office, Panjin Center for Disease Control and Prevention, Panjin, Liaoning Province, China. School of Food Science, Northeast Agricultural University Department of Hematology, Xiangya Hospital of Central South University, Changsha, China. Ultrasound Medical Center, Zhujiang Hospital of Southern Medical University, Guangzhou 510282, China State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, China;; Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing, China Department of Ophthalmology & Visual Sciences, University of Texas Medical Branch, Galveston, TX 77555, USA; Department of Neuroscience, Cell Biology & Anatomy, University of Texas Medical Branch, Galveston, TX 77555, USA National Clinical Research Center for Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China Department of Pathology Jiangsu Cancer Hospital, Affiliated Cancer Hospital of Nanjing Medical University Nanjing Jiangsu China The MOE Key Laboratory for Standardization of Chinese Medicines and the SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica Shanghai University of Traditional Chinese Medicine Shanghai China Department of Neonatology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China. Department of Hand Surgery, Wuhan Fourth Hospital, Puai Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China Cardiovascular Research Institute, Xianning College, Xianning 437100, P.R. China.; Department of Cardiology, Renmin Hospital, Wuhan University School of Medicine, Wuhan 430060, P.R. China.; Department of Physiology, Shantou University Medical College, Shantou, P.R. China. Department of Obstetrics, International Peace Maternity and Child Health Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai 200030, China. Email: drchenyixin@hotmail.com. Department of Chemistry and Chemical Engineering Hunan Institute of Science and Technology Yueyang China State Key Laboratory of Biotherapy and Cancer Center West China Hospital, and West China School of Basic Medical Sciences & Forensic Medicine Sichuan University, and Collaborative Innovation Center for Biotherapy Chengdu China State Key Laboratory of Southwestern Chinese Medicine Resources , Chengdu, Sichuan , China; School of Public Health, Chengdu University of Traditional Chinese Medicine , Chengdu, Sichuan , China; College of Pharmacy, Chengdu University of Traditional Chinese Medicine , Chengdu, Sichuan , China College of Materials Science and Engineering Fuzhou University Fuzhou 350108 China Department of Pharmacology, State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, P.R. China Product Development Bristol‐Myers Squibb Princeton New Jersey College of Chemistry and Materials Science, Anhui Normal University, Key Laboratory of Functional Molecular Solids, Ministry of Education, Anhui Laboratory of Molecular-Based Materials, Anhui Key Laboratory of Chemo-Biosensing, Wuhu 241002, China School of Life Science, Anhui University, Hefei, Anhui, China Hainan Key Laboratory for Sustainable Utilization of Tropical Bioresources, College of Tropical Crops, Hainan University, Haikou, China *Chinese Academy of Sciences Key Laboratory of Pathogenic Microbiology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China; Department of Materials Science and Engineering National University of Singapore 117576 Singapore Singapore Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, Shanghai Key Laboratory of New Drug Design, Engineering Research Center of Pharmaceutical Process Chemistry, Ministry of Education, School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China Institute of Animal Science; Chinese Academy of Agricultural Science; Beijing 100193 China School of Pharmacy, Anhui Medical University, Hefei 230032, China Department of Gastrointestinal Surgery, First Hospital of Jilin University, Changchun, Jilin, China University of Alberta Edmonton Alberta Canada China National Center for Food Safety Risk Assessment, Chaoyang District, Beijing, P.R. China Department of Blood Transfusion, Zhujiang Hospital, The Souther Medical University, Guangzhou 510282, China. Obstetrics Department, International Peace Maternity and Child Health Hospital, Medical College, Shanghai Jiao Tong University, Shanghai, China; Department of Aerospace Physiology, the Fourth Military Medical University, Xi'an 710032, China. Department of Nephrology, the Second Affiliated Hospital of Nanchang University, Nanchang, China College of Material Chemistry and Chemical Engineering Hangzhou Normal University Hangzhou P. R. China Department of Nursing, The Affiliated Haian Hospital of Nantong University, Nantong, Jiangsu Province, China Jiangsu Province, Key Laboratory of Neurodegeneration Nanjing Medical University Nanjing China; Brain Institute the Affiliated Nanjing Brain Hospital of Nanjing Medical University Nanjing China Key Laboratory of Coastal Zone Environmental Processes, Yantai Institute of Coastal Zone Research (YIC), Chinese Academy of Sciences (CAS), Shandong Provincial Key Laboratory of Coastal Zone Environmental Processes, YICCAS, Yantai, Shandong 264003, P. R. China Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences (SIBS), Chinese Academy of Sciences, Shanghai 200031, China Key Laboratory of New Drug Delivery System of Chinese Meteria Medica, Jiangsu Provincial Academy of Chinese Medicine, Nanjing 210028, China. Department of Physiology, Guiyang Medical University, Guiyang 550004, China; State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Carcinogenesis and Intervention, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009, China Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Xinjiang Medical University, Urumqi, Xinjiang Uyghur Autonomous Region 830017, P.R. China Department of Hematology, Zhongshan Hospital, Xiamen University, Xiamen, Fujian 361004, P.R. China Zhoushan Center for Disease Control and Prevention, Zhejiang Provincial Key Laboratory of Health Risk Factors for Seafood Department of Biology, Southern University of Science and Technology, Shenzhen, 518055, Guangdong, China Department of Gastroenterology, Affiliated Hangzhou First People’s Hospital, Zhejiang University School of Medicine, Hangzhou, China; Key Laboratory of Integrated Traditional Chinese and Western Medicine for Biliary and Pancreatic Diseases of Zhejiang Province, Hangzhou, China; Hangzhou Institute of Digestive Diseases, Hangzhou, China College of Animal Science and Technology Shihezi University Shihezi China Department of Obstetrics and Gynecology, Qilu Hospital of Shandong University, Jinan 250012, China. Institute of Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention, Beijing 100050, China. Neutron Scattering Division, Oak Ridge National Laboratory, Oak Ridge, TN 37831, USA School of Medical Instrument and Food Engineering, Shanghai Engineering Research Center of Food Microbiology University of Shanghai for Science and Technology Shanghai China Department of Neonatology Xinhua Hospital School of Medicine Shanghai Jiao Tong University Shanghai China State Key Laboratory of Infrared Physics; Shanghai Institute of Technical Physics; Chinese Academy of Sciences; Shanghai 200083; China Center for Research at Bio/Nano Interface, Department of Chemistry & Department of Physiology & Functional Genomics, Shands Cancer Center, UF Genetics Institute and McKnight Brain Institute, University of Florida, Gainesville, FL 32611, USA Department of Cardiology, The Second Hospital of Dalian Medical University Dalian, Liaoning, China. School of Life Sciences, Anhui University, Hefei, Anhui, PR China; Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China; University of Chinese Academy of Sciences, Beijing, China Elekta (Shanghai) Instruments Ltd Shanghai China School of Information Engineering, Southwest University of Science and Technology, Mianyang 621010, China Department of Hepatobiliary and Pancreatic Surgery, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China; Zhejiang Provincial Key Laboratory of Pancreatic Disease, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China Center for Research at the Bio/Nano Interface, Department of Chemistry and Department of Physiology and Functional Genomics, Shands Cancer Center, UF Genetics Institute and McKnight Brain Institute, University of Florida, Gainesville, Florida 32611-7200, and Foundation for Applied Molecular Evolution, 1115 NW Fourth Street, Gainesville, Florida 32601 Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, China; Jiangsu Provincial Academy of Traditional Chinese Medicine, Nanjing, China Departments of *Molecular Genetics, Zhejiang Provincial Key Laboratory of Biometrology and Inspection & Quarantine, Department of Pharmacy, College of Life Sciences, China Jiliang University, Hangzhou 310018, China Department of Oral Pathology, Peking University School and Hospital of Stomatology, Beijing 100081, China. Wuya College of Innovation; Shenyang Pharmaceutical University; Shenyang 110016; China Department of Orthodontics, School of Dentistry, Kyungpook National University, Daegu 700-412, Korea. Shanghai Key Laboratory of Orthopedic Implants Department of Orthopedics Ninth People's Hospital Shanghai Jiao Tong University School of Medicine 639 Zhizaoju Road Shanghai 200011 P. R. China Jiangsu Institute of Hematology, Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, The First Affiliated Hospital of Soochow University, Suzhou, PR China Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, 294 Taiyuan Road, Shanghai 200031, China Department of Cell BiologyNew York University School of Medicine New York New York USA Key Laboratory of Southwestern Chinese Medicine Resources Chengdu University of Traditional Chinese Medicine Chengdu China Schizophrenia Program, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, China; Department of Pharmacy Affiliated Taizhou People's Hospital of Nanjing Medical University Taizhou P. R. China Lingnan Normal University, Guangdong, Zhanjiang, China; Normal Human Anatomy and Histological Embryology Department, Yunnan University of Traditional Chinese Medicine , Kunming , Yunnan, 650500 , China Ultrasound Medical Center, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong, China. Department of Biopharmaceutical Sciences Department of Gynaecology and Obstetrics, People's Hospital of Lishui City, The Sixth Affiliated Hospital of Wenzhou Medical University, The Affiliated Hospital of Lishui College, Lishui, Zhejiang 323000, P.R. China Huashan Rare Disease Center and Department of Neurology Huashan Hospital, Shanghai Medical College, National Center for Neurological Disorders, Fudan University Shanghai China University of Nottingham, School of Medicine, Translational Medical Sciences, Clinical Sciences Building, City Hospital Campus, Hucknall Road, Nottingham, United Kingdom Department of Neurology, Renmin Hospital of Wuhan University, Wuhan, Hubei, China Department of Hematology Department of Pain Medicine, Guiyang Guizhou Provincial Orthopaedics Hospital, Guiyang 550000, China *Department of Medical and Molecular Genetics, Indiana University School of Medicine and the Walther Cancer Institute, Indianapolis, IN 46202;; Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China Jiangsu Provincial Academy of Traditional Chinese Medicine, Nanjing, China. College of Pharmacy, University of Cincinnati Medical Center, Cincinnati, OH Department of Hematology, Xiangya Hospital, Central South University, Changsha 410008. yanchen2018@csu.edu.cn. National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha 410008. yanchen2018@csu.edu.cn. Hunan Hematologic Neoplasms Clinical Medical Research Center, Changsha 410008. yanchen2018@csu.edu.cn. National Clinical Research Center for Hematologic Diseases, First Affiliated Hospital of Soochow University, Suzhou Jiangshu 215006, China. yanchen2018@csu.edu.cn. Research Unit of Food Safety (No.2019RU014), Chinese Academy of Medical Sciences: NHC Key Laboratory of Food Safety Risk Assessment, China National Center for Food Safety Risk Assessment (CFSA), Beijing, China. Department of Laboratory Medicine, The Third Affiliated Hospital of Soochow University , Changzhou, Jiangsu, China Department of Infectious Diseases, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Linhai, Zhejiang, China Joint BioEnergy Institute (JBEI), Emeryville, California 94608, United States; Biological Systems & Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States; DOE Agile BioFoundry, Emeryville, California 94608, United States Department of Neurology, Zhongnan Hospital, Wuhan University, Wuhan 430071, China. School of Chemistry and Material Science; Shanxi Normal University; Linfen 041004; China Center of Therapeutic Research for Hepatocellular Carcinoma, Beijing 302 Hospital, Beijing, China School of Life Science and Technology, Nanyang Normal University, Nanyang 473061, China. Department of Infectious Diseases, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, China Morningside Laboratory for Chemical Biology, Department of Chemistry, and Department of Surgery, The University of Hong Kong, Pokfulam Road, Hong Kong, People’s Republic of China Joint BioEnergy Institute, Emeryville, California, USA; Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA Department of Geriatrics The First Affiliated Hospital of Chongqing Medical University Chongqing China ENT Institute and Department of Otorhinolaryngology, Affiliated Eye and ENT Hospital, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai 200031, P.R. China Department of Nephrology, Jiangsu Province Official Hospital, Nanjing, Jiangsu, China Institut de Chimie Moléculaire et des Matériaux d’Orsay (ICMMO), CNRS UMR 8182, Université Paris-Saclay, Bâtiment 420, 91405 Cedex Orsay, France Division of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China Jiangsu Key Laboratory of Carcinogenesis and Intervention, China Pharmaceutical University, 210009 Nanjing, People’s Republic of China; Jiangsu Simcere Pharmaceutical Research Co., Ltd., 210042 Nanjing, People’s Republic of China; and Jiangsu Center for Pharmacodynamics Research and Evaluation, 210009 Nanjing, People’s Republic of China Department of Obstetrics and Gynecology, The Fourth Affiliated Hospital of Nanjing Medical University, Nanjing, China College of Animal Science and Veterinary Medicine Heilongjiang Bayi Agricultural University Daqing China School of Materials Science and Engineering; Southwest University of Science and Technology; Mianyang 621010; China; Engineering Research Center of Biomass Materials Department of Emergency, The First People's Hospital of Changzhou, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu 213003, P.R. China Oncology Disease Area and Developmental and Molecular Pathways, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts Department of Chemistry, Georgia State University, Atlanta, Georgia 30302, United States School of Chemical Engineering Dalian University of Technology Linggong Road 2 Dalian 116024 China Center for Health Research, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China Department of Pathology Jiangsu Cancer Hospital Nanjing China National Engineering Research Center of Seafood College of Food Science Dalian Polytechnic University Dalian China School of Life Sciences and Anhui Key Laboratory of Modern Biomanufacturing; Anhui University; Hefei 230601; P. R. China Department of Radiology, China–Japan Friendship Hospital, Beijing, China Department of Chemistry and Waksman Institute, Rutgers University, New Brunswick, NJ 08855, USA. Division of Human Anatomy Loma Linda University School of Medicine Loma Linda CA USA Department of Biochemistry, Duke University Medical Center, Durham, North Carolina 27710 Shanghai Key Laboratory of New Drug Design; School of Pharmacy; East China; University of Science and Technology; Shanghai 200237 Department of Cardiology, Center for Coronary Heart Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China Department of Electrical and Computer Engineering, University of Delaware, Newark, Delaware Program in Toxicology, College of Pharmacy, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131, Pathology and Physiology Research Branch, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, and Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana 46202 College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China; Joint International Research Laboratory of Agriculture and Agri-Product Safety, The Ministry of Education of China, Yangzhou University, Yangzhou 225009, China Department of Obstetrics and Gynaecology The Second Clinical Medical College, Yangtze University, Jingzhou Central Hospital Jingzhou China Department of Chemistry, University of Nebraska-Lincoln, Lincoln, NE, USA. Yunnan Tumor Institute, The Third Affiliated Hospital of Kunming Medical University, Yunnan Tumor Hospital, Kunming - China State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai, China. Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China, 2Saw Swee Hock School of Public Health and Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore and 3NUS Environmental Research Institute, National University of Singapore, Singapore Department of Neurology First People's Hospital of Zhaoqing Zhaoqing People's Republic of China Department of Health Management Center, Institute of Health Management, Sichuan Provincial People's Hospital University of Electronic Science and Technology of China Chengdu China; School of Public Health Southwest Medical University Luzhou China Department of Surgery, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong Island, Hong Kong, People's Republic of China; Department of Chemistry, The University of Hong Kong, Hong Kong, People's Republic of China School of Physics and Astronomy, University of Minnesota, 116 Church Street Southeast, Minneapolis, MN 55455; and Department of Pharmacology, University of Minnesota, 6-120 Jackson Hall, 321 Church Street Southeast, Minneapolis, MN 55455 State Key Laboratory of Food Science and Technology, Nanchang University, No. 235 Nanjing East Road, Nanchang 330047, Jiangxi, China Department of Clinical Laboratory, Fujian Provincial Key Laboratory of Tumor Biotherapy, Fujian Provincial Cancer Hospital, Teaching Hospital of Fujian Medical University, Fuzhou, Fujian, China Department of Veterinary Internal medicine & Clinical Diagnosis College of Veterinary Medicine, Yangzhou University Yangzhou Jiangsu People's Republic of China; Joint International Research Laboratory of Agriculture and Agri‐Product Safety of the Ministry of Education of China Yangzhou University Yangzhou Jiangsu People's Republic of China; Jiangsu Co‐Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses Yangzhou Jiangsu People's Republic of China Department of Public Health Sciences (Y.C., Y.Y.), University of Alberta, Edmonton, Alberta, Canada T6G 1C9; Writing Committee for the REMAP-CAP Investigators Department of Otorhinolaryngology, Hearing Research Institute, Affiliated Eye and ENT Hospital of Fudan University, Shanghai, China; Central Laboratory, Affiliated Eye and ENT Hospital of Fudan University, Shanghai, China From the Leeds/Wakefield Breast Screening Unit, Leeds Teaching Hospital NHS Trust, Seacroft Hospital, York Road, Leeds LS14 6UH, England (N.S., M.M., I.H., B.J.G.D.); and Applied Vision Research Centre, Loughborough University, Loughborough, England (Y.C.). School of Physics and Astronomy, University of Minnesota, 116 Church Street Southeast, Minneapolis, MN 55455 Department of Gynaecology and Obstetrics, The First Affiliated Hospital of Anhui Medical University Hefei 230022, China. School of Pharmaceutical Sciences, Wuhan University, Wuhan, China. Department of Psychiatry, Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang 310014, P.R. China Key Laboratory of State Forestry Administration on Biodiversity Conservation in Karst Mountainous Areas of Southwestern China Guizhou Normal University Guiyang China; School of Life Sciences Guizhou Normal University Guiyang China Department of Obstetrics and Gynecology, International Peace Maternity and Child Health Hospital Affiliated to Shanghai Jiao Tong University, Shanghai, People's Republic of China Department of Neurology Drum Tower Hospital, Nanjing Medical University Nanjing China Department of General Medicine, Panyu Central Hospital, Guangzhou, China International Peace Maternity and Child Health Hospital School of Medicine Shanghai Jiao Tong University Shanghai China State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang, China; Sino-German Food Engineering Center, Nanchang University, Nanchang, China; Food Engineering Department, Life Science and Food Engineering College, Nanchang University, Nanchang, China School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, China The Second Department of Pediatrics, Affiliated Hospital of Zunyi Medical University , Zunyi, Guizhou, China Hainan Center for Disease Control & Prevention, Hainan, China; Department of Liver Diseases, Fifth Medical Center of Chinese PLA General Hospital, Beijing, China; Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325000, China Dalian Institute for Food Control Dalian Food and Drug Administration Liaoning China Department of Systems Science and Industrial Engineering Binghamton University Binghamton New York USA School of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, Shanghai 200093, PR China Second Department of Pediatrics, Affiliated Hospital of Zunyi Medical College,Zunyi 563003,Guizhou Province,China. E-mail:cyz600@ 163.com. Department of Endocrinology The Seventh Affiliated Hospital of Sun Yat‐sen University Shenzhen China School of Civil Engineering; Qingdao University of Technology; Qingdao 266033; People's Republic of China †Unit of Critical Care, National Heart and Lung Institute Division, Imperial College School of Medicine, London, United Kingdom; and Department of Obstetrics and Gynecology, West China Second Hospital, Sichuan University, Chengdu 610041, China. Department of Infectious Diseases, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, 3 Qingchun Road, Hangzhou, Zhejiang 310016, PR China Department of Liver Diseases & the Fifth Medical Center of the Chinese People’s Liberation Army General Hospital, Beijing, China Xi’an Center for Disease Control and Prevention 599 Xiying Road Xi’an 710054 China Department of Chemistry, University of Nebraska-Lincoln, Lincoln, Nebraska 68588, United States Normal Human Anatomy and Histological Embryology Department, Yunnan University of Traditional Chinese Medicine, Kunming, China College of Agriculture and Bioengineering, Heze University, Heze, China Department of Physical Examination Center Hexian Peoples Hospital Ma Anshan City Anhui Province PR. China State Key Laboratory of Electroanalytical Chemistry Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun 130022, P. R. China; University of the Chinese Academy of Sciences, Beijing 100039, China Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Key Laboratory of Animal (Poultry) Genetics Breeding and Reproduction Ministry of Agriculture and Rural Affairs Beijing China Integrative Medicine and Neurobiology, State Key Laboratory of Medical Neurobiology, Shanghai Medical College, Fudan University, Shanghai, China, 200032; and Key Laboratory for Organic Electronics and Information Displays, Jiangsu Key Laboratory for Biosensors, Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing University of Posts and Telecommunications, Nanjing 210023, P. R. China Cardiology Division, Department of Medicine Queen Mary Hospital, University of Hong Kong Hong Kong SAR China; Cardiology Division, Department of Medicine University of Hong Kong Shenzhen Hospital Shenzhen China College of Fisheries and Life Science, Hainan Tropical Ocean University, Sanya, China School of Pharmacy, Anhui University of Traditional Chinese Medicine, Hefei, Anhui, P.R. China 1Department of Endocrinology (Diabetes and Metabolism)Rigshospitalet, Copenhagen, Denmark 1 ENT Institute and Otorhinolaryngology Department of the Affiliated Eye and ENT Hospital, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, People's Republic of China; 2 Institutes of Biomedical Sciences, Fudan University, Shanghai, People's Republic of China School of Life Science and Technology, Lingnan Normal University, Zhanjiang, Guangdong, China; Department of Cardiology, Taishan People's Hospital School of Chemistry and Chemical Engineering; College of Materials Science and Engineering; Shandong Provincial Key Laboratory/Collaborative Innovation Center of Chemical Energy Storage; Liaocheng University; China Prenatal Diagnosis Center, International Peace Maternity and Child Health Hospital, Shanghai Jiaotong University, Shanghai, China Department of Oral Pathology Peking University School and Hospital of Stomatology & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology Beijing People's Republic of China Department of Pharmacology, Columbia University, New York, United States Department of Food Quality and Safety; College of Food Science and Engineering; Jilin University; Changchun; P. R. China Department of Gastroenterology, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China. Key Laboratory of Earth and Planetary Physics, Institute of Geology and Geophysics, Chinese Academy of Sciences , Beijing, China The State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, People’s Republic of China; High Efficacy Application of Natural Medicinal Resources Engineering Center of Guizhou Province, High Educational Key Laboratory of Guizhou Province for Natural Medicinal Pharmacology and Drug Ability, Key Laboratory of Optimal Utilization of Natural Medicinal Resources, Guizhou Medical University, Guiyang, People’s Republic of China Department of Dermatology, Kunming General Hospital of Chengdu Military Region, Kunming, P.R. China Pharmacology Department of Medical School; Yangzhou University; Yangzhou; People's Republic of China; Jiangsu Co-innovation Center of Prevention and Control of Important Animal Infectious Diseases and Zoonosed Department of anesthesiology, Second Affiliated Hospital of Zhengzhou University, Zhengzhou, China Department of Biological Sciences, University of Calgary, Calgary, AB, Canada; and Department of Neurophysiology, Oilfields General Hospital in Daqing, Daqing, Heilongjiang 163001, P.R. China Comprehensive Liver Cancer Center, Beijing 302 Hospital, Beijing, China (mainland) Key Laboratory for Organic Electronics and Information Displays & Institute of Advanced Materials, Jiangsu National Synergetic Innovation Center for Advanced Materials, Nanjing University of Posts & Telecommunications, Nanjing, 210023, China Department of Obstetrics and Gynecology, West China Second University Hospital Sichuan University Chengdu China; Reproductive Endocrinology and Regulation Laboratory, West China Second University Hospital Sichuan University Chengdu China; Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University) Ministry of Education Chengdu China; The Joint Laboratory for Reproductive Medicine of Sichuan University‐The Chinese University of Hong Kong Chengdu China Department of Dermatology, Southwest Hospital, Third Military Medical University, Chongqing, China; Department of Dermatology, Kunming General Hospital of Chengdu Military Region, Kunming, China Laboratory of Biochemistry and Molecular Biology Research, Fujian Provincial Key Laboratory of Tumor Biotherapy, Department of Clinical Laboratory, Fujian Cancer Hospital, Fujian Medical University Cancer Hospital Fuzhou, P. R. China. Department of Gastroenterology Shanghai Engineering Research Center of Food Microbiology; School of Medical Instrument and Food Engineering; University of Shanghai for Science and Technology; Shanghai 200093; China Department of Infectious Diseases, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China; Key Laboratory of Microbial Technology and Bioinformatics of Zhejiang Province, Hangzhou, China Division of Periodontology, Diagnostic Sciences and Dental Hygiene, and Division of Biomedical Sciences, Herman Ostrow School of Dentistry, University of Southern California, Los Angeles, California 90089, United States Institute of Rocket Force Medicine, State Key Laboratory of Trauma, Burns and Combined Injury, Third Military Medical University (Army Medical University), Chongqing 400038, China Johns Hopkins University, Baltimore, MD Department of Anesthesiology, Zhuji People’s Hospital, Zhuji, Zhejiang, China Department of Respiratory and Critical Care Medicine, General Hospital of Northern Theater Command, Shenyang, Liaoning 110016, P.R. China Rigel PharmaceuticalsSouth San FranciscoCaliforniaUSA Department of Cardiology, Institute of Cardiovascular Diseases, First Affiliated Hospital of Wuhan University, Wuhan, Hubei, China; Department of Cardiology, Ezhou Central Hospital, Wuhan University, Ezhou, China Department of Orthopaedics, Biological Engineering and Regenerative Medicine Center, Tongji Hospital, Tongji Medical College, HuaZhong University of Science and Technology, Wuhan 430030, China Department of Gastroenterology Changhai Hospital, Second Military Medical University Shanghai China Department of Orthopaedics and Rehabilitation, Yale University School of Medicine, New Haven, Connecticut, U.S.A. Jiangsu Taipuriu Biotechnology Co., Ltd, Taizhou Pharmaceutical City, Jiangsu, 225300, China Chinese Medicine Department Songnan Town Community Health Service Center Baoshan District Shanghai 200441 China Guizhou Medical University, Guiyang, People’s Republic of China; Department of Pediatrics, Affiliated Hospital of Zunyi Medical University, Zunyi, People’s Republic of China Biotechnology and Process Design, Core Research and Development, Diagnostics Division and Advanced Technology, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, Illinois 60064 Key Laboratory of Modem Chinese Medicines, China Pharmaceutical University, Ministry of Education, Nanjing 210009, China. laurayan.125@163.com State Key Laboratory of Surface Physics and Department of Physics, Fudan University, Shanghai 200433, China Wuya College of Innovation Shenyang Pharmaceutical University Shenyang 110016 P. R. China Department of Pharmaceutical Sciences, School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, China Department of Cell Biology and the State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China State Key Laboratory of Polymer Material and Engineering, College of Polymer Science and Engineering, Sichuan University, Chengdu 610065, P. R. China Beijing National Laboratory for Molecular Sciences, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China, and Center for Research at the Bio/Nano Interface, Department of Chemistry and Department of Physiology and Functional Genomics, Shands Cancer Center, UF Genetics Institute, McKnight Brain Institute, University of Florida, Gainesville, Florida 32611-7200 Ministry of Education-Shanghai Key Laboratory of Children’s Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China School of Public Health University of Alberta Edmonton Alberta Canada Key Laboratory of Protein Modification and Degradation, School of Basic Medical Sciences; Affiliated Cancer Hospital and Institute, Guangzhou Medical University, Guangzhou, China 1Department of Pathology, Shanghai Cancer Hospital, Fudan University, Shanghai, China; 3Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha State Key Laboratory of Structural Chemistry; Fujian Institute of Research on the Structure of Matter; Chinese Academy of Sciences; Fuzhou 350002; P. R. China School of Life Sciences, Key Laboratory of Eco-engineering and Biotechnology of Anhui Province and Anhui Key Laboratory of Modern Biomanufacturing, Anhui University, Hefei 230601, Anhui, PR China Department of Radiochemistry, China Institute of Atomic Energy, Beijing 102413, China Division of Cardiology, Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China Department of Clinical Pharmacy, School of Pharmaceutical Sciences, Jilin University, Jilin, Changchun 130021, P.R. China Department of Oncology, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China. chenyan@fmmu.edu.cn Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province College of Animal Science and Technology Northwest A&F University Yangling China Department of Radiology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, PR China 4Institute of Big Data and Internet Innovation, Hunan University of Commerce, Changsha, China Department of Obstetrics and Gynecology, the Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China Department of Clinical Laboratory, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu 213003, P.R. China Department of Pharmacy, School of Pharmacy and Pharmacology, University of Strathclyde, Glasgow G1 1XW, UK From the Departments of Pathology (Drs Coberly and F. Chen, Mr Armanini, and Mrs Y. Chen) and Cell Biology (Drs Mather and Loo and Mr Young), MacroGenics West, Inc, South San Francisco, California. Dr Coberly is now with the Department of Pathology, Amgen, South San Francisco, California. State Key Laboratory of Fine Chemicals, Frontier Science Center for Smart Materials School of Chemical Engineering Dalian University of Technology Linggong Road 2 Dalian 116024 China Research & Development SeekIn Inc. Shenzhen China State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China Jiangsu Institute of Hematology, National Clinical Research Center for Hematologic Diseases, NHC Key Laboratory of Thrombosis and Hemostasis, the First Affiliated Hospital of Soochow University Soochow University Suzhou China; Institute of Blood and Marrow Transplantation, Collaborative Innovation Center of Hematology Soochow University Suzhou China Center for Research at the Bio/Nano Interface, Department of Chemistry and Department of Physiology and Functional Genomics, Shands Cancer Center, UF Genetics Institute and McKnight Brain Institute, University of Florida, Gainesville, Florida 32611-7200, Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, 361005, People’s Republic of China, and Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285 Department of Gastroenterology Renmin Hospital of Wuhan University Wuhan PR China; Key Laboratory of Hubei Province for Digestive System Disease Wuhan PR China School of Business, Macau University of Science and Technology, Macau 999078, China Department of PediatricsAffiliated Hospital of Zunyi Medical University Zunyi China Department of Applied Physics The Hong Kong Polytechnic University Hung Hom, Kowloon Hong Kong P. R. China Pathogen Molecular Genetics Section, Laboratory of Bacteriology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA Echocardiography and Vascular Ultrasound Center The First Affiliated Hospital College of Medicine Zhejiang University Hangzhou China Center for Research at Bio/nano Interface, Department of Chemistry and Department of Physiology and Functional Genomics, Shands Cancer Center, UF Genetics Institute and McKnight Brain Institute, University of Florida, Gainesville, Florida 32611-7200, and Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, 101, Sec 2, Kuang Fu Road, Hsinchu, Taiwan, ROC 30013 Division of Cardiology, Department of Medicine The University of Hong Kong Shenzhen Hospital Shenzhen China Department of Genetic Identification, Erasmus MC University Medical Center Rotterdam, Rotterdam, the Netherlands; Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China; University of Chinese Academy of Sciences, Beijing, China. Department of Neurosurgery, Sun Yat-sen University, First Affiliated Hospital, Guangzhou City, Guangdong Province, China State Key Laboratory of Inorganic Synthesis & Preparative Chemistry, Jilin University, Changchun 130012, China Department of Urology, Johns Hopkins University School of Medicine, Baltimore, Maryland Institute for Molecular Virology, University of Minnesota, Minneapolis, Minnesota, USA; School of Physics and Astronomy, University of Minnesota, Minneapolis, Minnesota, USA Center of Inflammatory Bowel Disease, Department of Gastroenterology The Second Affiliated Hospital of Zhejiang University School of Medicine Hangzhou P. R. China Department of Ultrasonic Diagnosis; Zhujiang Hospital of Southern Medical University; Guangzhou 510282 China Institute of Spine, Shanghai University of Traditional Chinese Medicine, 725 Wan-Ping South Road, Shanghai 200032, China; Department of Orthopaedics & Traumatology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China Clinical Laboratory Department, Fujian Medical University Teaching Hospital, Fuzhou, Fujian, China. yanc99@sina.com State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu, Sichuan 610041, China Key Laboratory of Cell Activities and Stress Adaptations Ministry of Education School of Life Sciences Lanzhou University Lanzhou 730000 China Department of Biochemistry & Molecular Biology, Shanxi Medical University, Taiyuan, China; Biotechnology Research Laboratory, Capital Institute of Pediatrics, Beijing, China Department of Surgery, The First Affiliated Hospital of Soochow University, Suzhou 215006, China; Department of Pathology, School of Biology & Basic Medical Sciences, Soochow University, Suzhou 215123, China Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, 200031, China. ychen3@sibs.ac.cn. Department of Education, Three Gorges University, Yichang, P. R. China. Department of Endocrinology, Multidisciplinary Diabetic Foot Medical Center, Chongqing Emergency Medical Center, Chongqing University Central Hospital, Chongqing University, Chongqing, China Department of Dermatology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China; The First Clinical Academy, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China; Department of Dermatology, Yangjiang People’s Hospital, Yangjiang, Guangdong, China; Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, Hefei, Anhui, China Clinical Immunology Center of PLA, Changzheng Hospital, Second Military Medical University, Shanghai, China College of Pharmacy Jinan University Guangzhou 510632 China Department of Discovery Chemistry, Bristol Myers Squibb Research and Early Development, 5 Research Parkway, Wallingford, Connecticut06492, United States Institute of Molecular Engineering and Applied Chemistry; Anhui University of Technology; Ma'anshan 243002; China Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University), Ministry of Education, Shenyang 110016, People’s Republic of China Department of Hematology, Zhongshan Hospital Affiliated to Xiamen University, Xiamen 361004, Fujian Province, China. Department of Bone and Joint Surgery the First Affiliated Hospital of Guangxi Medical University Nanning China Department of Protein Analytical Chemistry, Genentech, Inc., 1 DNA way, South San Francisco, California 94080-4990, United States Department of Pharmaceutical Sciences, College of Pharmaceutical Sciences, Soochow University, Suzho Howard Hughes Medical Institute and Departments of Internal Medicine, Cellular and Molecular Physiology, and Cell Biology, Yale University School of Medicine, New Haven, CT 06510; Department of Medicine, Columbia University, New York, NY 10032; and Laboratory of Biochemical Genetics and Metabolism, Rockefeller University, New York, NY 10021 Department of Thoracic-Cardiovascular Surgery; Tongji Hospital; Tongji University School of Medicine; Shanghai China Institute for Nutritional Sciences, Chinese Academy of Sciences, Shanghai 200031, China Division of Cancer and Stem Cell School of Medicine at University of Nottingham Nottingham UK Orthopedic Center, Ningbo NO. 2 Hospital, Ningbo Zhejiang 315010, China. Department of Endocrinology and Metabolism The First Affiliated Hospital of Sun Yat‐sen University Guangzhou Guangdong China Comprehensive Liver Cancer Center,Beijing 302 Hospital,Beijing,China Department of Neurology, Tianjin Huanhu Hospital, Tianjin, P.R. China. Institute of Basic Theory for Chinese Medicine China Academy of Chinese Medical Sciences Beijing China InnoStar Bio-tech Nantong Co., Ltd., Building A18, 100 Dongtinghu Road, Linjiang Town, Haimen District, Nantong City, Jiangsu Province, 226133 P.R. China Renmin Hospital of Wuhan University, Wuhan 430060, China School of Electrical Engineering and Computer Science, Washington State University, Pullman, Washington 99164-2752 Department of Molecular, Microbial and Structural Biology, University of Connecticut Health Center, Farmington, Connecticut 06030 Aab Cardiovascular Research Institute, Department of Medicine, University of Rochester College of Pharmacy, Zhejiang Chinese Medicine University, Hangzhou, China;; Institute of Materia Medica, Zhejiang Academy of Medical Science, Hangzhou, China; Department of Pharmacy Xijing Hospital of the Fourth Military Medical University Xi’an China Pfizer Inc , Collegeville, PA , USA Biostatistics University of Alberta Calgary Alberta Canada Qiushi Academy for Advanced Studies; Zhejiang University; Hangzhou; China Zhejiang University of Technology, Hangzhou, China The Education Ministry Key Lab of Resource Chemistry, Joint International Research Laboratory of Resource Chemistry, Ministry of Education, Shanghai Key Laboratory of Rare Earth Functional Materials, College of Chemistry and Materials Science, Shanghai Normal University, Shanghai 200234, China Science Systems and Applications, Inc. Hampton Virginia USA Division of Cardiology, Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Room 1929B, Block K, 102 Pokfulam Road, Hong Kong, China; Division of Cardiology, Department of Medicine, The University of Hong Kong Shenzhen Hospital, Shenzhen, China Frequency Control Laboratory, School of Automation and Engineering, University of Electronic Science and Technology of China, Chengdu, China. yanchencd@163.com College of Life and Environment Sciences, Shanghai Normal University, Shanghai 200234, PR China National Clinical Research Center for Metabolic Diseases, Key Laboratory of Diabetes Immunology (Central South University), Ministry of Education, and Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University , Changsha, Hunan 410011 , China Department of Respiratory Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China 2School of Public Health, University of Alberta, Edmonton, Alberta, Canada. Key Laboratory of Functional Molecular Engineering of Guangdong Province, School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, China National & Local Joint Engineering Laboratory for New Petro-chemical Materials and Fine Utilization of Resources, Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research, Ministry of Education, Key Laboratory of the Assembly and Application of Organic Functional Molecules of Hunan Province, Hunan Normal University, Changsha, Hunan 410081, China School of Life Sciences, Northeast Normal University, Changchun, China; Baicheng Medical College, Baicheng, China Department of Industrial & Physical Pharmacy, College of Pharmacy, Purdue University, West Lafayette, IN 47907, USA; Department of Pharmaceutics, School of Pharmacy, Second Military Medical University, Shanghai, 200433, China The Second Department of Pediatrics, Affiliated Hospital of Zunyi , Zunyi, Guizhou , China Department of Clinical Laboratory Medicine Shanghai Tenth People's Hospital of Tongji University Shanghai China School of Food Science and Technology Dalian Polytechnic University Dalian Liaoning; National Engineering Research Center of Seafood Dalian Liaoning Beijing Genomics Institute-Shenzhen, Shenzhen 518083, China; Jiangsu Provincial Academy of Traditional Chinese Medicine, Jiangsu Engineering and Technology Research Center for Modern Chinese Pharmaceutical Preparation, Nanjing 210028, China. ychen202@yahoo.com.cn Chinese Academy of Medical Sciences Research Unit (No. 2019RU014), China National Center for Food Safety Risk Assessment, Beijing 100021, China Key Laboratory of Earth and Planetary Physics, Institute of Geology and Geophysics, Chinese Academy of Sciences, Beijing, China. Beijing Sport University Beijing China Key Laboratory for Organic Electronics and Information Displays & Institute of Advanced Materials, Jiangsu National Synergetic Innovation Center for Advanced Materials, Nanjing University of Posts and Telecommunications, Nanjing 210023, China State Key Laboratory of Soil and Sustainable Agriculture, Institute of Soil Science, Chinese Academy of Sciences , 210008 Nanjing, China Department of Obstetrics, International Peace Maternity & Child Health Hospital, Shanghai Jiaotong University Medical School, Shanghai, People's Republic of China; Division of Maternal Fetal Medicine, Department of Obstetrics & Gynecology, The Ohio State University College of Medicine, Columbus, Ohio Department of Respiratory and Critical Care Medicine Second Xiangya Hospital Central South University Changsha Hunan 410011 China; Research Unit of Respiratory Disease Central South University Changsha Hunan 410011 China; Diagnosis and Treatment Center of Respiratory Disease Central South University Changsha Hunan 410011 China From the Department of Pharmacology and Molecular Cardiobiology Program (J.F., D.F., Y.C., T.A.F., T.J.M., W.C.S.), Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, Conn; and the Institute of Molecular and Cellular Biosciences (N.F., T.T.), Bunkyo-ku, Tokyo, Japan. Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, China and Department of General Surgery and Laparoscopic Center Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou People's Republic of China Institut de Chimie Moléculaire et des Matériaux d'Orsay (ICMMO) CNRS UMR 8182 Université Paris-Saclay Bâtiment 420 91405 Orsay cedex France |
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