http://rdf.ncbi.nlm.nih.gov/pubchem/author/MD5_4f29941cf138848bf1d0f04696a784ac
Outgoing Links
Predicate | Object |
---|---|
family-name | Li Jie Li |
name | Jie Li |
given-name | Jie |
organization-name | School of Metallurgy and Environment Central South University Changsha 410083 Hunan P.R. China College of Animal Science and Technology, Northwest A&F University, Xi'an, Shaanxi, China; College of Animal Science and Technology, Innovation Experimental College, Northwest A&F University, Xi'an, Shaanxi, China The Affiliated Brain Hospital of Guangzhou Medical University Chongqing Academy of Animal Sciences, Rongchang, Chongqing, China Department of Pharmacology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China; Department of General Surgery Qianfoshan Hospital Shandong University Jinan China School of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin, China Changsha University of Science and Technology 1 School of Physics and Electronic Sciences, , Changsha 410004, People's Republic of China State Key Laboratory of Reproductive Medicine, Department of Urology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, and Jiangsu Shengze Hospital, Wujiang, China. College of Pharmacy, National & Local Joint Engineering Research Center of Targeted and Innovative Therapeutics, IATTI, Chongqing University of Arts and Sciences, Chongqing 402160, China Guang'anmen Hospital, China Academy of Chinese Medical Sciences Beijing 100053, China. Department of Oncology, Mianyang Central Hospital, Mianyang, Sichuan, China College of Food Science and Technology, Huazhong Agriculture University, Wuhan 430070, China; Aquatic Vegetable Preservation and Processing Technology Engineering Center of Hubei Province, Wuhan 430070, China Department of Ultrasound, Qilu Hospital of Shandong University, Jinan, Shandong 250012, P.R. China Beijing Institute of Basic Medical Sciences, Beijing, China Department of Oncology, Affiliated Qingdao Central Hospital of Qingdao University, Qingdao Cancer Hospital, Qingdao 266042, China Department of Thoracic Surgery, The General Hospital of Chinese People’s Liberation Army, Beijing, China (mainland) College of Food Science and Engineering, Tarim University, Alar 843300, China; Corps Key Laboratory of Deep Processing of Specialty Agricultural Products in Southern Xinjiang, Alar 843300, China State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences , 100101 Beijing, China Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, USA. Nanjing Forestry University Department of Nephropathy, Xi’an Central Hospital, Xi’an 710003, Shaanxi, China Laboratory of Membrane Biology, New York Blood Center, New York, NY;; School of Life Sciences, Zhengzhou University, Zhengzhou, Henan, China; Beijing National Laboratory for Molecular Sciences, Synthetic and Functional Biomolecules Center, Department of Chemical Biology, College of Chemistry and Molecular Engineering, Peking University, Beijing, China Beijing Institute of Biological Products Company Limited, Beijing 100176, China Center for Reproductive Medicine, Renmin Hospital of Wuhan University, Hubei Clinic Research Center for Assisted Reproductive Technology and Embryonic Development, Wuhan, 430060 Hebei Province, China Department of Otorhinolaryngology Head and Neck Surgery, Yongchuan Hospital of Chongqing Medical University , Chongqing , 402160 , China CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, RNAM Center for Marine Microbiology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou, 510301, PR China Department of Orthodontics, Hebei Key Laboratory of Stomatology, Hebei Clinical Research Center for Oral Diseases, School and Hospital of Stomatology, Hebei Medical University, Shijiazhuang, People's Republic of China. Department of Clinical Research Center, Dazhou Central Hospital, Dazhou, Sichuan, China Center for Theoretical and Applied Neuro-Oncology, Moores Cancer Center, Division of Neurosurgery, University of California San Diego, La Jolla, CA, USA Pearl River Fisheries Research Institute Chinese Academy of Fishery Science Guangzhou China; Key Laboratory of Aquatic Animal Immune Technology of Guangdong Province Guangzhou China; Guangzhou Scientific Observing and Experimental Station of National Fisheries Resources and Environment Guangzhou China; Experimental Station for Scientific Observation on Fishery Resources and Environment in the Middle and Lower Reaches of Pearl River Zhaoqing China Department of Radiology and Huaxi MR Research Center (HMRRC), Functional and Molecular Imaging Key Laboratory of Sichuan Province and Frontiers Science Center for Disease Related Molecular Network West China Hospital, Sichuan University, Chengdu 610041, China Department of Thyroid Surgery, Cangzhou Central Hospital, Cangzhou, Hebei, China Key Laboratory of Functional Polymer Materials of Ministry Education; Institute of Polymer Chemistry; College of Chemistry; Nankai University; Tianjin 300071 Department of Outpatient, Outpatient of Jinan Municipal People’s Government, Jinan, China Department of Plant Pathology, College of Plant Protection, China Agricultural University, Beijing 100193, China School of Chemistry and Chemical Engineering Central South University Changsha 410083 China Department of Nephrology Yongchuan People's Hospital of Chongqing Chongqing China Department of Ultrasound, Zhengzhou University Third Hospital and Henan Province Women, Zhengzhou, China Department of Chemistry and Biochemistry; and Center for Organic Photonics and Electronics Research (OPERA); Kyushu University; Fukuoka 819-0395, Japan School of Metallurgy and Environment Central South University Changsha Hunan 410083 P. R. China Department of Ultrasound, Qilu Hospital, Cheeloo College of Medicine Shandong University Jinan China Radiation Oncology Department Sichuan Cancer Hospital Chengdu 610041 People's Republic of China Department of General Surgery, Shandong, Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong Province, China; Department of General Surgery, The First Affiliated Hospital of Shandong First Medical University, Jinan, Shandong Province, China Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China Department of Oncology, Mianyang Central Hospital, Mianyang, Sichuan, China (mainland) Department of Thoracic and Cardiac Surgery, Drum Tower Medical College of Nanjing Medical University, Nanjing 210029, China. Department of Gastrointestinal Oncology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital & Institute, Beijing, China Department of Gynecology and Obstetrics, Tianjin Medical University General Hospital, Tianjin China Department of Orthopedics Surgery, Tianjin Hospital, Tianjin, China Department of Endocrinology, Nanjing General Hospital of Nanjing Military Command (Jinling Hospital), 305 East Zhongshan Road, Nanjing, Jiangsu 210002, China Department of Psychology and Behavioral Sciences, Zhejiang University, Hangzhou, China; Section of Applied Psychology, Beijing Sport University, Beijing, China Molecular Pathogenesis Unit, Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland Key Laboratory of Marine Bio-Resources Sustainable Utilization, RNAM Center for Marine Microbiology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, PR China; Key Laboratory of Microbial Diversity in Southwest China, Ministry of Education, and Laboratory for Conservation and Utilization of Bio-Resources, Yunnan Institute of Microbiology, Yunnan University, Kunming, Yunnan 650091, PR China Department of Neurology the People's Hospital of Deyang City Deyang Sichuan China Department of Orthopaedic Trauma, The 80th Group Army Hospital of The People’s Liberation Army of China, Weifang, Shandong, China (mainland) CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, RNAM Center for Marine Microbiology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, PR China Ordered Matter Science Research Center, Jiangsu Key Laboratory for Science and Applications of Molecular Ferroelectrics, Southeast University, Nanjing 211189, People's Republic of China Key Laboratory of Luminescence Analysis and Molecular Sensing (Southwest University), Ministry of Education, School of Materials and Energy, Southwest University, Chongqing 400715, P. R. China; Chongqing Key Lab for Advanced Materials and Clean Energies of Technologies, Southwest University, Chongqing 400715, P. R. China From The University of Texas M. D. Anderson Cancer Center, Houston, TX; Myriad Genetics, Salt Lake City, UT; and University of California San Francisco, San Francisco, CA. Department of Anesthesiology Tianjin Medical University General Hospital Tianjin China; Anaesthesiology, The Graduate School Tianjin Medical University Tianjin China Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China School of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, PR China. Fax: +86-511-88797201; Tel: +86-511-88797202 State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China Department of Gastrointestinal and Colorectal Surgery, China-Japan Union Hospital of Jilin University, Changchun, Ji Lin, China Guangzhou University of Traditional Chinese Medicine, Guangzhou, Guangdong Province, China; State Key Laboratory of Dampness Syndrome of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province, China; Guangdong Provincial Key Laboratory of Research on Emergency in TCM, Guangzhou, Guangdong Province, China The Reproductive Hospital of Guangxi Zhuang Autonomous Region, Nanning, PR China Key Laboratory of Comparative Medicine, Department of Veterinary Surgery, College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China Department of Endocrinology, Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing 210008, China; Department of Endocrinology, Nanjing Central Hospital, Nanjing 210008, China From the State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China; the 2Department of Ophthalmology, Nanhai Hospital, Southern Medical University, Foshan, China; *Department of Ultrasonography, Shandong Provincial Hospital Affiliated to Shandong University; †Department of Ultrasonography, Qilu Hospital of Shandong University; and ‡Department of Geriatric Respiratory, Shandong Provincial Qianfoshan Hospital Affiliated to Shandong University, Jinan City, Shandong Province, PR China. State Key Laboratory of Medicinal Chemical Biology; College of Life Sciences; Nankai University; Tianjin, China Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China Department of Laboratory Medicine, Taihe Hospital, Shiyan, Hubei 442000, China. 3561361@qq.com. Department of Gastroenterology, The First Affiliated Hospital of Yangtze University, Jingzhou, Hubei 434000, P.R. China Frontiers Science Center for High Energy Material Advanced Technology Research Institute (Jinan) Beijing Key Laboratory of Photoelectronic/Electrophotonic Conversion Materials School of Chemistry and Chemical Engineering Beijing Institute of Technology Beijing 100081 P. R. China 2University of Chinese Academy of Sciences, Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, 200031, PR China †Pathology, Duke University Medical Center, Durham, NC 27710 Advanced Water Management Centre, The University of Queensland, St. Lucia, Queensland 4072, Australia Department of Laboratory Medicine, Peking University Shenzhen Hospital, Shenzhen, People’s Republic of China; Institute of STD/AIDS Prevention and Treatment, Beijing Center Disease Prevention and Control, Beijing, China. Department of Cardiology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University , 106, Zhongshaner Rd, Yuexiu Disctict, Guangzhou, Guangdong 510080 , China Department of Natural Medicine, School of Pharmacy, The Fourth Military Medical University, Xi'an, Shaanxi 710032, P.R. China Beijing Key Laboratory of Diagnostic and Traceability Technologies for Food Poisoning; Beijing Center for Disease Prevention and Control; Beijing China Division of Chemistry and Physical Biology, School of Physical Science and Technology, ShanghaiTech University, Shanghai 201210, China State Key Laboratory of Integrated Services Networks, School of Electronic Engineering, Xidian University, Xi’an, China Beijing National Laboratory for Molecular Sciences; Institution College of Chemistry and Molecular Engineering; Peking University; Beijing; China Shanghai Institute of Organic Chemistry, CAS, Shanghai 200032, China Thyroid and Breast Surgery Department of Cardiology The First Affiliated Hospital, Sun Yet‐sen University Guangzhou China; Key Laboratory on Assisted Circulation Ministry of Health Guangzhou China School of Physical Science and Technology ShanghaiTech University 393 Middle Huaxia Road Shanghai 201210 China Department of Orthopedics First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine Guangzhou Guangdong China College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, P.R. China Department of Endocrinology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, P.R. China. Department of Natural Medicine, School of Pharmacy, Fourth Military Medical University, 169 West Changle Road, Xi’an, Shaanxi 710032, China School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China. Department of Rheumatology, Qilu Hospital, Shandong University, Jinan, Shandong, China (mainland) State Key Laboratory of Coordination Chemistry School of Chemistry and Chemical Engineering Nanjing University Nanjing 210023 China Department of Infectious Diseases, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China; Institute of Viruses and Infectious Diseases, Nanjing University, Nanjing, Jiangsu, China; Department of Infectious Diseases, Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China Fujian Entry-Exit Inspection and Quarantine Bureau, Fuzhou, Fujian 350001, People’s Republic of China Department of Allergy, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology (HUST) Wuhan China Department of Orthopedics surgery, Ningbo Medical Center Li Huili Hospital, Affiliated to Ningbo University, Ningbo 315040, Zhejiang, China Department of Interventional Radiology Affiliated Hospital of Jiangnan University Wuxi China Institute of Resources and Environmental Engineering, Shanxi University, Taiyuan 030006, China Department of Pancreatic and Biliary Surgery, First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, China. Key Laboratory of Hepatosplenic Surgery, Ministry of Education, The First Affiliated Hospital of Harbin Medical University, Harbin, China Department of Food Science, Cook College, The New Jersey Agricultural Experiment Station, Rutgers, The State University of New Jersey, New Brunswick, New Jersey 08901 National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention/State Key Laboratory for Infectious Disease Prevention and Control, Beijing, China, and Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou, China School of Laboratory Medicine Youjiang Medical University for Nationalities Baise Guangxi People's Republic of China Department of Cardiopulmonary Sciences, Division of Respiratory Care Rush University Medical Center Chicago Illinois Zhejiang Provincial Key Laboratory of Chemical Utilization of Forestry Biomass, College of Chemistry and Materials Engineering, Zhejiang A&F University, Hangzhou, Zhejiang 311300, China Department of Oncology, Fuzhou General Hospital of Nanjing Military Command, Fuzhou, Fujian 350025, P.R. China Department of Ophthalmology, The People‘s Hospital of Zhengzhou University, Zhengzhou, China Institution of Intelligent Technology and Engineering Chongqing University of Science and Technology Chongqing China School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China Department of Pulmonary Disease, Hubei Hospital of Traditional Chinese Medicine, Wuhan, Hubei 430000, P.R. China Department of Pediatric Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, China Department of Orthopedics, The First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine, Guangzhou, China Department of Oncology, Xin Hua Hospital Cancer Center, Shanghai Second Medical University, Shanghai 200092, China. Division of Neurosurgery, University of California, San Diego, La Jolla, CA 92093; Key Laboratory of Marine Bio-resources Sustainable Utilization CAS, RNAH Center for Marine Microbiology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, PR China Department of Breast and Thyroid Surgery The First Affiliated Hospital of Sun Yat‐sen University Guangzhou Guangdong China Section of Applied Psychology, Beijing Sport University, Beijing, People’s Republic of China Department of Chemistry and Biochemistry, University of California, Santa Cruz, California 95064, United States Noiselab, Scripps Institute of Oceanography, University of California , San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA Neurology Department, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China Center for Health Management and Policy School of Public Health National Health Commission Key Laboratory of Health Economics and Policy Cheeloo College of Medicine Shandong University Jinan China Department of Anatomy and Histology, School of Basic Medical Sciences Tianjin Medical University Tianjin China; TEDA International Cardiovascular Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Tianjin China; Key Laboratory of Hormones and Development (Ministry of Health), Tianjin Key Laboratory of Metabolic Diseases Tianjin Medical University Tianjin China 17th Department of Plastic Surgery, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100041, China Key Laboratory of Radiopharmaceuticals Ministry of Education College of Chemistry Beijing Normal University Beijing 100875 P.R. China Department of Chemistry, Tsinghua University, Key Laboratory of Organic Optoelectronics & Molecular Engineering of Ministry of Education, Beijing 100084, China Institute of Chemical Materials China Academy of Engineering Physics Mianyang 621900 P. R. China Department of Neurology, People’s Hospital of Deyang City, Deyang 618000, Sichuan, China Division of Respiratory Care, Department of Cardiopulmonary Sciences, Rush University Medical Center, Chicago, Illinois. Department of Chemistry and Biochemistry University of California Santa CruzCalifornia; The Parkinson's Institute 1170 Morse Avenue SunnyvaleCalifornia Department of Obstetrics and Gynecology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400014, China. Department of Psychiatry, Tianjin Anding Hospital, Tianjin 300222, China State Key Laboratory of Drug Research Shanghai Institute of Materia Medica Chinese Academy of Sciences Shanghai 201203 China Department of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing 211198, China Department of Hepatobiliary Surgery; Qianfoshan Hospital; Shandong University; Jinan Shandong Province China Frontiers Science Center for High Energy Material, Advanced Technology Research Institute (Jinan), Beijing Key Laboratory of Photoelectronic/Electrophotonic Conversion Materials, School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing 100081, P. R. China a Department of Statistics , Virginia Tech , Blacksburg , Virginia , USA Department of Anesthesiology, The First Affiliated Hospital of Southwest Medical University, Luzhou, People’s Republic of China Synthetic and Functional Biomolecules Center, Beijing National Laboratory for Molecular Sciences, Department of Chemical Biology, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China School of Physics, Henan Normal University, Xinxiang, Henan province, China Department of Breast Surgery, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China, 100020 Yichang Key Laboratory of Development and Utilization of Health Products with Drug Food Homology & Hubei Key Laboratory of Natural Products Research and Development, China Three Gorges University, Yichang, P.R. China Center for Carbon‐based Electronics and Key Laboratory for the Physics and Chemistry of Nanodevices School of Electronics Peking University Beijing 100871 China Department of Hematology, the Second Hospital, Hebei Medical University, Shijiazhuang 050017, PR China. Department of Hematology, Hebei General Hospital, Shijiazhuang 050000, Hebei Province, China, E-mail: doclijie@163.com. School of Chemistry, National and Local Joint Engineering Research Center of MPTES in High Energy and Safety LIBs Engineering Research Center of MTEES (Ministry of Education), and Key Lab. of ETESPG (GHEI) South China Normal University Guangzhou 510006 P. R. China Institute of Robotics and Automatic Information System College of Artificial Intelligence, Nankai University Tianjin China; Tianjin Key Laboratory of Intelligent Robotics Nankai University Tianjin China National Engineering Laboratory for Cereal Fermentation Technology (NELCF), School of Biotechnology, Jiangnan University, 1800 Lihu Road, Wuxi, Jiangsu 214122, China Department of Nutrition and Food Hygiene, Public Health College Harbin Medical University Harbin China Intensive Care Unit, Fuxing Hospital, Capital Medical University, Beijing 100038, China. College of Animal Science and Technology; Northwest A&F University; Yangling 712100; P. R. China Department of Psychiatry Functional Neuroimaging Laboratory, Tianjin Mental Health Center, Tianjin Anding Hospital , Tianjin , China Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, 201210 Shanghai, China;; School of Life Science and Technology, ShanghaiTech University, 201210 Shanghai, China;; Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 200031 Shanghai, China;; University of Chinese Academy of Sciences, 100049 Beijing, China; Department of GI Oncology, Key laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University School of Oncology, Beijing Cancer Hospital & Institute, Beijing, China Department of Surgery Duke University Durham NC USA Office of Surveillance and Epidemiology, Center for Drug Evaluation and Research, United States Food and Drug Administration , Silver Spring, MD 20993, United States Shenzhen Bay Laboratory, Shenzhen 518132, China Engineering Research Center of Ministry of Education on Groundwater Pollution Control and Remediation, College of Water Sciences, Beijing Normal University, Beijing, People’s Republic of China State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences , No.1 Beichen West Road, Chaoyang District, Beijing 100101, China Department of Biochemistry, Purdue University, West Lafayette, Indiana, USA School for Radiological and Interdisciplinary Sciences (RAD-X), Soochow University, 215123, Suzhou, P. R. China; Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, 215123, Suzhou, P. R. China Key Laboratory of Tropical Marine Bio-resources and Ecology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, China Jiangsu Textiles Quality Services Inspection Testing Institute, Nanjing 210007, P. R. China Department of Otorhinolaryngology, First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China. Department of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 Department of Nutrition and Genome Center University of California Davis CA USA Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, Ohio 43210, United States College of Clinical Medicine, Jilin University, Ji Lin, China *Division of Gastroenterology-Hepatology, Department of Internal Medicine, University of Iowa, Iowa City, IA 52242; Air Traffic Control and Navigation College, Air Force Engineering University 1 , Xi’an 710000, China State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X), and Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou 215123, China State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials, and College of Life Sciences Nankai University Tianjin 300071 P. R. China Jiangxi Province Key Laboratory of Preventive Medicine, School of Public Health Nanchang University Nanchang China Guangdong Key Laboratory of Ornamental Plant Germplasm Innovation and Utilization, Environmental Horticulture Research Institute, Guangdong Academy of Agricultural Sciences, Guangzhou 510640, China Key Laboratory of Marine Bio-resources Sustainable Utilization CAS, RNAM Center for Marine Microbiology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, PR China Department of Oncology, Changhai Hospital, The Naval Military Medical University, Shanghai, China Department of Pharmacy Shanghai Jiao Tong University Affiliated Sixth People's Hospital Shanghai 200233 China Key Laboratory for Organic Electronics and Information Displays (KLOEID) & Institute of Advanced Materials (IAM); Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM); Nanjing University of Posts & Telecommunications; Nanjing 210023; China Department of Pathology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China. Key Laboratory of Marine Bio-resources Sustainable Utilization CAS, RNAM Center for Marine Microbiology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, PR China; Key Laboratory of Microbial Diversity in Southwest China, Ministry of Education and Laboratory for Conservation and Utilization of Bio-Resources, Yunnan Institute of Microbiology, Yunnan University, Kunming, 650091, PR China State Key Laboratory of Photon-Technology in Western China Energy; Institute of Photonics and Photon-Technology; Northwest University; Xi'an; China State Key Laboratory of Organic Electronics and Information Displays & Jiangsu Key Laboratory for Biosensors, Institute of Advanced Materials (IAM), Nanjing University of Posts and Telecommunications, 9 Wenyuan Road, Nanjing 210023, China Key Laboratory of Polyoxometalate Chemistry of Henan Province, School of Chemistry and Chemical Engineering, Henan University, Kaifeng 475004, P. R. China The Third Department of Orthopedics and Traumatology of Traditional Chinese Medicine, The First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine, Guangzhou, Guangdong 510405, P.R. China Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland; Chengdu University of Traditional Chinese Medicine, Chengdu, China Department of Chemistry and Biochemistry, Utah State University, 0300 Old Main Hill, Logan, Utah 84322-0300 National Institute for Communicable Disease Control and Prevention, China CDC/State Key Laboratory for Infectious Disease Prevention and Control, Beijing, China, and Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou, China Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Dongcheng, Beijing 100730, People’s Republic of China College of Chemical and Environmental Engineering, Chongqing University of Arts and Sciences, Chongqing 402160, PR China Department of Molecular Microbiology and Immunology, Oregon Health & Science University, Portland, Oregon 97239, United States Department of Radiation Oncology Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China Chengdu China; Radiation Oncology Key Laboratory of Sichuan Province Chengdu China Cancer Centre and Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, Taipa, Macau SAR 999078, China; MoE Frontiers Science Center for Precision Oncology, University of Macau, Taipa, Macau SAR 999078, China; Key Laboratory of Flexible Electronics (KLOFE) and Institute of Advanced Materials (IAM), Nanjing Tech University (NanjingTech), Nanjing 210009, China Division of Molecular and Cellular Pathology, Department of Pathology and Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China ; Department of Ophthalmology, Nanhai Hospital, Southern Medical University, Foshan 528200, Guangdong Province, China. College of Environmental Science and Engineering State Key Laboratory of Pollution Control and Resource Reuse Tongji University Shanghai 200092 P. R. China Department of Physiology, State Key Laboratory of Common Mechanism Research for Major Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Basic Medical Sciences and School of Basic Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, China China Agricultural University College of Horticulture, , Beijing 100193, China University of Idaho, Department of Microbiology, Molecular Biology, and Biochemistry, Moscow, Idaho 83844-3052 Beijing Key Laboratory of Function Materials for Molecule & Structure Construction, School of Materials Science and Engineering, University of Science and Technology Beijing, 30 Xueyuan Road, Beijing 100083, P. R. China Cancer Centre and Institute of Translational Medicine Faculty of Health Sciences University of Macau Macau SAR 999078 China; Key Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM) Nanjing Tech University (NanjingTech) Nanjing 210009 China Department of Oncology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, People's Republic of China Reproductive Medicine Center; for The First Affiliated Hospital of Sun Yat-sen University, Key Laboratory of Reproductive Medicine of Guangdong Province; Sun Yat-sen University; Guangzhou China Department of Thoracic Surgery The First Medical Center of Chinese PLA General Hospital Beijing China School of Pharmaceutical Sciences, Hainan University, Haikou 570100, China State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences , Beijing 100101 , China; University of Chinese Academy of Sciences , Beijing 100049 , China Institute of Electrostatics and Special Power, Dalian University of Technology, Dalian 116024, PR China, and Key Laboratory of Industrial Ecology and Environmental Engineering, Ministry of Education of the People’s Republic of China, Dalian 116024, PR China Department of Anesthesiology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510120, China Department of Dermatology Xiangya Hospital Central South University Changsha China; Hunan Key Laboratory of Skin Cancer and Psoriasis Xiangya Hospital Central South University Changsha China; Hunan Engineering Research Center of Skin Health and Disease Changsha China; National Clinical Research Center for Geriatric Disorders Xiangya Hospital Changsha China; Xiangya Clinical Research Center for Cancer Immunotherapy Central South University Changsha China Shanghai Fifth People's Hospital, Fudan University, and Shanghai Key Laboratory of Medical Epigenetics, International Co-laboratory of Medical Epigenetics and Metabolism (Ministry of Science and Technology), Institutes of Biomedical Sciences, Fudan University , Shanghai 200032, China College of First Clinical Medicine, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China Department of General Surgery Peking Union Medical College Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Beijing People's Republic of China Department of Respiratory Medicine, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Taiyuan, Shanxi, China Department of Emergency, Ningbo No. 2 Hospital, Ningbo, Zhejiang 315040, P.R. China Guangzhou Brain Hospital, Guangzhou, China Department of Pathology, Yale University School of Medicine, New Haven, Connecticut; Key Laboratory of Molecular Biology on Infectious Diseases Ministry of Education, Chongqing Medical University Chongqing China 7New Jersey State Cancer Registry, State of New Jersey, Department of Health, Trenton, New Jersey. Pathology, and Key Laboratory of Marine Bio-resources Sustainable Utilization (CAS), RNAM Center for Marine Microbiology (CAS), Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, PR China Jiangsu Textiles Quality Services Inspection Testing Institute, Nanjing 210007, China Department of Psychiatry, Tianjin Anding Hospital, Tianjin Mental Health Center, Tianjin, China Department of Bioengineering, School of Environmental and Biological Engineering Nanjing University of Science and Technology Nanjing China Institute of Gynaecology and Obstetrics, General Hospital of PLA, Beijing 100853, China 0000 0001 0085 4987 grid.252245.6 School of Life Sciences, School of Chemistry and Chemical Engineering, Institute of Physical Science and Information Technology Anhui University 230601 Hefei China Center for Musculoskeletal Research University of Rochester School of Medicine and Dentistry Rochester New York Department of Endocrinology and Metabolism, Shanghai Clinical Center for Diabetes, Shanghai Key Clinical Center for Metabolic Disease, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, China Department of Immunology, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China.E-mail: 164757254 @qq.com. Department of Urology, 2nd Affiliated Hospital, 3rd Military Medical University, Chongqing, China From the Division of Basic Biomedical Sciences, Sanford School of Medicine of the University of South Dakota, Vermillion, SD (M.J.R., E.J.M.T., J.L., X.W.); and Division of Cardiology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD (M.J.R., D.A.K.). Dr Li is now at the Vascular Biology Center, Georgia Regents University, Augusta, GA. Division of Vascular Surgery and Endovascular Therapy, University of Florida College of Medicine, Gainesville. Key Laboratory for the Physics and Chemistry of Nanodevices and Center for Carbon-Based Electronics, Department of Electronics, Peking University, Beijing 100871, China Australian Centre for Water and Environmental Biotechnology, Faculty of Engineering, Architecture and Information Technology, The University of Queensland , St Lucia, Queensland 4072, Australia Reproductive Medical Center, First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China. Department of Orthopaedics, The Second People’s Hospital of Yibin, Sichuan, P.R. China Department of Genetics, University of Georgia, Athens, GA 30602, USA College of Agronomy, Xinyang Agriculture and Forestry University , Xinyang , Henan, 464001 , China Institute of Neuroscience and The Collaborative Innovation Center for Brain Science, Chongqing Medical University, Chongqing 400016, P.R. China State Key Laboratory of Drug Research & Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China; Yantai Key Laboratory of Nanomedicine & Advanced Preparations, Yantai Institute of Materia Medica, Shandong 264000, China College of Physical Education, Northwest Normal University, Lanzhou 730070, China; Langfang Teachers College, Langfang 065000, China. lijie2005ty@126.com. State Key Laboratory of Analytical Chemistry for Life Science; School of Chemistry and Chemical Engineering; Nanjing University; Nanjing 210023; P.R. China State Key Laboratory of Medicinal Chemical Biology Nankai University Tianjin China; Department of Cell Biology and Genetics College of Life Sciences Nankai University Tianjin China Department of Neurology, Xinqiao Hospital & The Second Affiliated Hospital, The Army Medical University (Third Military Medical University), Chongqing, China Center for Integrative Conservation, Plant Phylogenetics and Conservation Group, Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences, Kunming, PR China; Department of Hepatobiliary Surgery, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, China Institute of Plant Protection, Henan Academy of Agricultural Sciences, Key Laboratory of Integrated Pest Management on Crops in Southern Region of North China, Henan Key Laboratory of Crop Pest Control, Zhengzhou 450002, China State Key Laboratory of Maternal and Fetal Medicine of Chongqing Municipality, First Affiliated Hospital of Chongqing Medical University , Chongqing, China From the Departments of Plastic Surgery and Human Resources, Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine; and Department of Plastic Surgery, Austin Hospital. Pearl River Fisheries Research Institute Chinese Academy of Fishery Science Guangzhou China Department of Blood Transfusion The General Hospital of Jinan Military Command Jinan P. R. China Shanghai Key Laboratory of New Drug Design, School of Pharmacy East China University of Science and Technology Shanghai 200237 China State Key Laboratory of Membrane Biology, Institute of Molecular Medicine, Peking University, 100871 Beijing, China; School of Brain Science and Brain Medicine, Zhejiang University, Hangzhou 310058, China. College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan 250014, Shandong, P. R. China Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian 350122, P.R. China Division of Molecular Medicine, Hefei National Laboratory for Physical Sciences at Microscale, The CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China, Hefei 230027, China. State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China. Zhejiang Provincial Engineering Technology Research Center of Marine Biomedical Products, School of Food and Pharmacy, Zhejiang Ocean University, Zhoushan, Zhejiang 316022, China Shaanxi Key Laboratory of Molecular Biology for Agriculture, College of Animal Science and Technology, Northwest A&F University, Yangling 712100, P. R. China Department of Urology, Lishui Central Hospital and Fifth Affiliated Hospital of Wenzhou Medical College, Lishui, China Medical Imaging Center, First Affiliated Hospital Jinan University Guangzhou Guangdong China; Medical Imaging Center Affiliated hospital of Hangzhou Normal University Hangzhou Zhejiang China Department of Infectious Disease, Shandong Provincial Hospital Affiliated to Shandong University, Shandong, China. Chengdu University of TCM, Sichuan 610075, China. janleesui545@hotmail.com Jiangsu Key Laboratory of Neuropsychiatric Diseases and Institute of Neuroscience, Soochow University Department of Pathology Chinese PLA General Hospital Beijing China Department of Pharmacy, Zhangjiagang Hospital of Traditional Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Zhangjiagang, Suzhou, Jiangsu 215600, China Guopei Luo, Kaizhou Jin, Chen Liu, Jin Xu, Quanxing Ni, and Xianjun Yu, Fudan University Shanghai Cancer Center; Chenghao Shao, Shanghai Changzheng Hospital; Wei Wang, Huadong Hospital, Fudan University, Shanghai; Yu Zhang, Minhu Chen, and Jie Chen, The First Affiliated Hospital, Sun Yat-Sen University; Wei Wang, Sun Yat-sen University Cancer Center; Jian Sun, Sun Yat-sen Memorial Hospital, Sun Yat-Sen University, Guangzhou; Huangying Tan, China-Japan Friendship Hospital; and Jie Li and Lin Shen, Peking... Anhui University of Chinese Medicine, Hefei, Anhui 230038, China Department of Nursing, Shenzhen Hospital, Southern Medical University, Shenzhen, China.; School of Nursing, Southern Medical University, Guangzhou, Guangdong, China. Department of Urology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China Tianjin Key Laboratory of Molecular Optoelectronic Sciences, Department of Chemistry, Institute of Molecular Aggregation Science, Tianjin University, 300072 Tianjin, China Department of Oncology, Changhai Hospital, The Second Military Medical University, Shanghai 200433, P.R. China School of Pharmaceutical Sciences, Jiangnan University, Lihu Road 1800, 214122 Wuxi, P. R. China Department of Cardiology, The People's Hospital of China Medical University, The People's Hospital of Liaoning Province, Shenyang, 110016, China Vascular Biology Center, Medical College of Georgia, Augusta University, Augusta, GA, United States Institute for Prevention and Control of STD and AIDS , Henan Provincial Center for Diseases Control and Prevention,Zhengzhou 450016, China. Center for Genomic and Personalized Medicine, Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region - PR China; Research Center for Guangxi Reproductive Medicine, First Affiliated Hospital of Guangxi Medical University, Guangxi Zhuang Autonomous Region - PR China School of Metallurgy and Environment, Central South University, Changsha 410083, People’s Republic of China Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI 48109-1085 Departement of Social and Behavioral Sciences, City University of Hong Kong, Hong Kong, China. Laboratory of Maricultural Organism Disease Control and Molecular Pathology, Yellow Sea Fishery Research Institute, Chinese Academy of Fishery Sciences, Qingdao, China Advanced Water Management Centre, The University of Queensland , St. Lucia, Brisbane, QLD, Australia Sugarcane Research Institute, Yunnan Academy of Agricultural Science, Yunnan Key Laboratory of Sugarcane Genetic Improvement, Kaiyuan 661699, China Department of Infectious Diseases Nanjing Drum Tower Hospital University Medical School Nanjing China State Key Laboratory of Heavy Oil Processing and Center for Biotechnology and Bioengineering, China University of Petroleum (East China), 66 Changjiang West Road, Qingdao 266580, China From the Stroke Clinical Research Unit, Department of Neurology (W.D.T., M.L., D.R.W., J.L., Z.L.H., S.L., C.F.Z., Q.T.Z., B.W.) and State Key Laboratory of Biotherapy and Cancer Center (M.L.), West China Hospital, Sichuan University; the J. Philip Kistler Stroke Research Center (W.D.T., K.L.F.), Department of Neurology, Massachusetts General Hospital, Boston, MA; and the Department of Neurology (M.F.), University of Massachusetts Medical School, Worcester, MA. College of Physical Education, Northwest Normal University, Lanzhou 730070, China. lijie2005ty@126.com Vascular Biology Center (J.L., H.S., Y.H., N.W.), Medical College of Georgia, Augusta University. Department of Intervention, Affiliated Hospital of Jiangnan University, The Forth People’s Hospital of Wuxi City, Wuxi, Jiangsu, China Department of Immunology, School of Basic Medical Sciences, Xinxiang Medical University , Xinxiang, Henan 453000, P.R.China; Xinxiang Key Laboratory of Tumor Vaccine and Immunotherapy, Xinxiang Medical University , Xinxiang, Henan 453000, P.R.China Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224, USA Department of Endocrinology, The Third Affiliated Hospital of Gansu University of Traditional Chinese Medicine, Baiyin 730900, China. Department of Respiratory and Critical Care, The Third People’s Hospital of Kunming , Kunming , Yunnan, 650041 China Department of Imagine, People’s Hospital of Jinan, Jinan 271100, Shandong Province, China Department of Pathology, Yale School of Medicine, New Haven, Connecticut 06520, United States Department of Cell Biology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 Nankai University Eye Institute Key Laboratory of Functional Polymer Materials of Ministry of Education Institute of Polymer Chemistry College of Chemistry Nankai University Tianjin 300071 China Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas 77555, Department of Pharmacology and Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences and Central Arkansas Veterans Healthcare System, Little Rock, Arkansas 72205, and Department of Chemistry and Biochemistry, University of Texas, Arlington, Texas 76019 NASA Ames Research Center, Moffett Field, CA 94035, USA.; SETI Institute, Mountain View, CA 94043, USA. Microbiome Medicine Center, Department of Laboratory Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China Department of Hepatobiliary Surgery First Affiliated Hospital Xi'an Jiaotong University China Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, Institution of South China Sea Ecology and Environmental Engineering, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, China; State Key Laboratory of Heavy Oil Processing and Centre for Bioengineering and Biotechnology China University of Petroleum (East China) Qingdao 266580 China CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, People’s Republic of China Pitzer Center for Theoretical Chemistry, Department of Chemistry, University of California, Berkeley, California 94720, United States CAS Key Laboratory of Pathogenic Microbiology and Immunology; Institute of Microbiology, Chinese Academy of Sciences; Beijing China Key Laboratory of Marine Bio-Resources Sustainable Utilization CAS, RNAM Center for Marine Microbiology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, PR China Department of General Surgery, Qianfoshan Hospital, Shandong University, Jinan, Shandong 250014, P.R. China Department of Hepatobiliary Surgery, Fuyang People’s Hospital , Fuyang, Anhui , China Department of Biosystems Engineering; Faculty of Agricultural and Food Sciences; University of Manitoba; Winnipeg R3T 2N2; Canada Division of Epidemiology Office of Pharmacovigilance and Epidemiology, Office of Surveillance and Epidemiology, Center for Drug Evaluation and Research, Food and Drug Administration Silver Spring Maryland USA Department of Nephrology, Central Hospital of Zhuzhou City and Affiliated Zhuzhou Hospital of Xiangya Medical College of Central South University, Zhuzhou, China Department of Clinical Laboratory, Shanghai Gongli Hospital , The Second Military Medical University , Shanghai , P.R. China a Key Laboratory of Urban Pollutant Conversion, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen 361021, China; b University of Chinese Academy of Sciences, Beijing 100049, China Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School , Boston, MA 02115 , USA Institute of Plasma Physics Chinese Academy of Sciences P. O. Box 1126 Hefei 230031 P.R. China; University of Science and Technology of China, Hefei 230026 P.R. China Department of Energy, Politecnico di Milano, Via Lambruschini 4, 20156 Milano, Italy Key Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM), Nanjing Tech University (NanjingTech), Nanjing 210009, P. R. China Department of Food Science, University of Guelph, Guelph, Ontario, Canada N1G 2W1 College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan 250014, Shandong, China Department of Infectious Disease, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, 325000, China State Key Laboratory of Microbial Resources, Institute of Microbiology Chinese Academy of Sciences Beijing 100101 China; University of Chinese Academy of Sciences, No. 19A Yuquan Road, Shijingshan District Beijing 100049 China 1Surgical Neurology Branch and Department of Head and Neck Oncology, Cancer Center, and State Key Laboratory of Biotherapy, West China Hospital of Sichuan University, Chengdu, Sichuan; Department of Oncology, Mian Yang Central Hospital, Mianyang Genome Center, Bioinformatics Core, University of California Davis, Davis, CA 95616, USA From the Department of Chemical Engineering (J.L., H.T., J.R.M., C.-H.L.), University of Texas at Austin, TX; Department of Neurology (S.A.B., E.M.), Dell Medical School, University of Texas at Austin, TX; Department of Chemistry & Molecular Biology (F.S., K.H.), University of Gothenburg, Sweden; Department of Neurology and Neurotherapeutics (C.J., N.M., B.M.G.), University of Texas Southwestern Medical Center, Dallas, TX; Department of Biomedical Engineering (J.E.K.), University of Texas at... State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China (W.P., M.Z., X.L., L.H., J.L., X.H., B.Z.). Department of Biology and Biochemistry, University of Houston, 369 Science and Research Building II, Houston, Texas 77204-5001 School of Medicine, Zhejiang University City College, Hangzhou, Zhejiang 310015, P.R. China State Key Laboratory of Medicinal Chemical Biology Nankai University Tianjin 300350 China; Department of Cell Biology and Genetics College of Life Sciences The Key Laboratory of Bioactive Materials, Ministry of Education Nankai University Tianjin 300071 China Key Laboratory of Functional Polymer Materials of Ministry of Education; Institute of Polymer Chemistry; College of Chemistry; Nankai University; Tianjin 300071 1Department of Clinical Laboratory, Chongqing Hospital of Traditional Chinese Medicine, Chongqing, China Beijing Institute of Basic Medical Sciences, 27 Taiping Road, Haidian District, Beijing 100850, China. Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, 730000 Gansu, China, State Key Laboratory of Gansu Advanced Non-ferrous Metal Materials, Lanzhou University of Technology, Lanzhou, 730050 Gansu, China, and School of Material Science and Engineering, Lanzhou University of Technology, Lanzhou, 730050 Gansu, China Department of Obstetrics and Gynecology, the Affiliated Drum and Tower Hospital of Medical School of Nanjing University, Nanjing, China State Key Laboratory of Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China Department of Infectious Disease, Shandong Provincial Hospital Affiliated to Shandong University,Jinan,China Laboratory of Molecular Sensory Science, Beijing Technology and Business University, No. 11, Fucheng Road, Haidian District, 100048 Beijing, China Affiliated Hospital of Nanjing University of Chinese Medicine State Key Laboratory of Photon‐Technology in Western China Energy Institute of Photonics and Photon‐Technology, Northwest University Xi'an Shaanxi China Department of Neurology, The Second Affiliated Hospital, Harbin Medical University, Harbin, Heilongjiang 150086, P.R. China Department of Plastic and Reconstructive Surgery, Shanghai Ninth People’s Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, P.R. China University of Chinese Academy of Sciences Beijing 100190 P. R. China; Beijing National Laboratory for Molecular Sciences CAS Key Laboratory of Organic Solids and Laboratory of Molecular Nanostructure and Nanotechnology Institute of Chemistry Chinese Academy of Sciences Beijing 100190 P. R. China Tianjin Key Laboratory of Molecular Optoelectronic Sciences Department of Chemistry Institute of Molecular Aggregation Science Tianjin University Tianjin 300072 China Department of Orthopaedics, The Second Affiliated Xinqiao Hospital of Army Medical University, Chongqing 400037, China School of Nursing Shandong University Jinan Shandong China State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, P. R. China for the STABLE-SR-III Investigators Department of Spine Surgery, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China School of Pharmaceutical Science, Jiangnan University, Lihu Road 1800, 214122 Wuxi, P. R. China Department of Infectious Disease,Shandong Provincial Hospital Affiliated to Shandong University,Ji'nan,Shandong,China College of Animal Science and Technology, Northwest A&F University, Yangling 712100, China School of Public Health, Shandong University, Shandong, People’s Republic of China School of Chemistry and Chemical Engineering, Central South University, Changsha, 410083, China Department of Orthopedics Shanghai Zhabei District Central Hospital Shanghai China College of Chemistry and Chemical Engineering; Jishou University; Jishou 416000; China State Key Laboratory of Common Mechanism Research for Major Diseases, Haihe Laboratory of Cell Ecosystem, Department of Physiology, Institutes of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; Department of Orthopedics, Xuzhou Central Hospital, Southeast University Xuzhou 221006, China. From the Institute of Ocular Pharmacology, School of Ophthalmology and Optometry, Wenzhou Medical College, Wenzhou, Zhejiang, China; and the College of Chemistry and Chemical Engineering, Xinyang Normal University, Xinyang, Henan 464000, China Beijing Children’s Hospital, Capital University of Medical Sciences, Beijing, China Department of Burns and Cutaneous Surgery, Xijing Hospital, Fourth Military Medical University, Xi’an, Shaanxi 710032, China. Institute for HIV/AIDS and STD Prevention and Control Beijing Center for Disease Prevention and Control Beijing China Center for AIE Research, College of Materials Science and Engineering, Shenzhen University, Shenzhen 518060, China Department of Infectious Disease, Shandong Provincial Hospital affiliated to Shandong University, Cheeloo College of Medicine, Shandong University, Ji’nan, Shandong, China; Department of Infectious Disease, Shandong Provincial Hospital affiliated to Shandong First Medical University, Jinan, Shandong, China Guangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation, College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China; National Laboratory of Safety Evaluation (Environmental Assessment) of Veterinary Drugs, College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China; National Risk Assessment Laboratory for Antimicrobial Resistance of Animal Original Bacteria, College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China Centre for Health Management and Policy Research, School of Public Health, Cheeloo College of Medicine, Shandong University , No. 44 Wenhuaxi Road, Jinan 250012, China Department of Gynecology and Obstetrics. Key Laboratory for Tumor Precision Medicine of Shaanxi Province, Center for Translational Medicine,the First Affiliated Hospital of Xiߣan Jiaotong University,Xiߣan 710061,China. Jiangsu Key Laboratory for the Research and Utilization of Plant Resources, The Jiangsu Provincial Platform for Conservation and Utilization of Agricultural Germplasm Institute of Botany, Jiangsu Province and Chinese Academy of Sciences Nanjing Jiangsu China College of Chemistry and Chemical Engineering, Jishou University, Jishou 416000, China Key Laboratory of Bioresources and Eco-environment, Ministry of Education, College of Life Science, Sichuan University, Chengdu, China. Department of Imaging, Maternity and Child Health Hospital of Zhenjiang, Zhenjiang, Jiangsu 212001, P.R. China Office of Surveillance and Epidemiology, CDER United States Food and Drug Administration Silver Spring Maryland USA National Center for Nanoscience and Technology; Beijing 100190 P. R. China Department of Epidemiology and Health Statistics, Anhui Medical University, Hefei 230032, China. Department of Radiation Oncology, Sichuan Cancer Hospital, 55 4th Section Renmin South Road, Chengdu, 610041, China Institute of Agricultural Engineering; Fujian Academy of Agricultural Sciences; Fuzhou; P.R. China Key Laboratory of Novel Thin Film Solar Cells, Institute of Plasma Physics, Chinese Academy of Sciences, P.O. Box 1126, Hefei 230031, P.R. China CAS Key Laboratory of Biofuels, Qingdao Institute of BioEnergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao 266101, China; Shandong Provincial Key Laboratory of Energy Genetics, Qingdao Institute of BioEnergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao 266101, China; Qingdao Engineering Laboratory of Single Cell Oil, Qingdao Institute of BioEnergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao 266101, China; University of Chinese Academy of Sciences, Beijing 100049, China College of Biotechnology & Food Science, Tianjin University of Commerce, Tianjin 300134, China Center for Reproductive Medicine, Shandong University, National Research Center for Assisted Reproductive Technology and Reproductive Genetics, The Key Laboratory for Reproductive Endocrinology of Ministry of Education, Jinan, Shandong 250000, China. gaoyuan@sduivf.com. School of Medicine University of Electronic Science and Technology of China & department of Pharmacy Sichuan Provincial People’s Hospital Chengdu China Department of Oncology, 900 Hospital of The Joint Logistics Team, Fuzhou, Fujian 350025, P.R. China Center for Research on Health Care, University of Pittsburgh, Pittsburgh, Pennsylvania Department of Obstetrics and Gynecology, Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School Nanjing China Guangdong Provincial Key Laboratory of Optical Fiber Sensing and Communications Institute of Photonics Technology Jinan University Guangzhou 511143 China State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical Technology 100029 Beijing China School of Life Sciences, Tsinghua-Peking Center for Life Sciences, Tsinghua University, China Department of Infectious Diseases Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School Nanjing China; Institute of Viruses and Infectious Diseases Nanjing University Nanjing China; Department of Infectious Diseases Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine Nanjing University of Chinese Medicine Nanjing China Center for Translational and Applied Neuro-oncology, Division of Neurosurgery, University of California, San Diego, CA College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang, China Department of Dermatology and Cutaneous Surgery University of Miami Miller School of Medicine Miami FL USA Key Laboratory of Pesticide & Chemical Biology of Ministry of Education, Institute of Environmental Chemistry, College of Chemistry Central China Normal University Wuhan 430079 P.R. China Hangzhou Institute of Advanced Studies, Zhejiang Normal University, 1108 Gengwen Road, Hangzhou 311231, China Department of Pathology, PLA General Hospital, Beijing 100853, China. State Key Laboratory of Reproductive Medicine and Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China Emergency Department, Maternity And Child Health Care Hospital Hubei, Women And Children's Hospital of Hubei Province, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China Department of Gastroenterology The Affiliated Cancer Hospital of Xiangya School of Medicine Central South University Changsha Hunan Province China Department of Biosystems Engineering, Faculty of Agricultural and Food Sciences, University of Manitoba, Winnipeg R3T 2N2, Canada Henan Key Laboratory of Polyoxometalate Chemistry; Institute of Molecular and Crystal Engineering; College of Chemistry and Chemical Engineering; Henan University; Kaifeng 475004 College of Artificial Intelligence, Southwest University, Chongqing 400715, China Department of Surgery, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada T6G 2S2 Department of Dermatology, Xiangya Hospital, Central South University, 87 Xiangya Rd, Changsha, Hunan, 410008, China. School of Materials Science and Engineering Zhejiang Sci-Tech University Hangzhou 310018 P. R. China University of California Davis Bioinformatics Core, Davis, California Key Laboratory of Laboratory Medicine, Ministry of Education, Wenzhou Key Laboratory of Cancer Pathogenesis and Translation, School of Laboratory Medical and Life Science , Wenzhou Medical University , Wenzhou 325035 , China for the GDLM group Department of Ultrasound, Qilu Hospital of Shandong University, Jinan, People’s Republic of China Department of Nursing, The Second Affiliated Hospital of Nantong University, Nantong, People’s Republic of China Chengdu University of TCM, Sichuan 610075, China. jan-leesui545@hotmail.com Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan, P.R. China; Key Laboratory of Hepatobiliary and Pancreatic Surgery and Digestive Organ Transplantation of Henan Province, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan, P.R. China CAS Key Laboratory of Tropical Marine Bio-Resources and Ecology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, China CAS Key Laboratory of Nanophotonic Materials and Devices & Key Laboratory of Nanodevices and Applications i‐Lab Suzhou Institute of Nano‐Tech and Nano‐Bionics (SINANO) Chinese Academy of Sciences Suzhou 215123 P. R. China Jiangsu Key Laboratory of Pesticide Science and Department of Chemistry, College of Sciences, Nanjing Agricultural University, Nanjing 210095, China Dalian Medical University, PR China School of Pharmaceutical Engineering and Life Science Changzhou University Changzhou P. R. China State Key Laboratory of Electronic Thin Film and Integrated Devices, University of Electronic Science and Technology, Chengdu 610054, China Department of Anatomy and Neurobiology, College of Medicine, University of California, Irvine, Irvine, CA 92697, USA for the Nasal Oscillation Post-Extubation (NASONE) Study Group Hefei National Research Center for Physical Sciences at the Microscale CAS Key Laboratory of Materials for Energy Conversion Department of Materials Science and Engineering University of Science and Technology of China Hefei 230026 P. R. China David H. Koch Institute for Integrative Cancer Research Massachusetts Institute of Technology Cambridge MA 02139 USA; Department of Anesthesiology Boston Children's Hospital Boston MA 02115 USA Department of Obstetrics, Ningbo Women and Children’s Hospital, Ningbo, Zhejiang, China Ordered Matter Science Research Center Jiangsu Key Laboratory for Science and Applications of Molecular Ferroelectrics Southeast University Nanjing 211189 P. R. China Department of Geriatrics, The First Hospital of Jilin University, Changchun 130021, Jilin, P.R. China Department of Neurosurgery, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China Beijing National Laboratory for Molecular Sciences, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China Geophysical Laboratory, Carnegie Institution of Washington, 5251 Broad Branch Road NW, Washington, DC 20015; and Consortium for Advanced Radiation Sources, University of Chicago, 9700 South Cass Avenue, Argonne, IL 60439 Department of Hepatobiliary Surgery, Fuyang People’s Hospital, Fuyang Department of Stomatology, Rizhao People’s Hospital, Jining Medical University, Rizhao, P.R. China Beijing Key Laboratory of Agricultural Genetic Resources and Biotechnology, Beijing Functional Flower Engineering Technology Research Center, Beijing Agro-Biotechnology Research Center, Beijing Academy of Agriculture and Forestry Sciences, Beijing, China; College of Landscape and Ecological Engineering, Hebei University of Engineering, Handan, China Department of Radiation Oncology, Sichuan Cancer Hospital and Institute, Radiation Oncology Key Laboratory of Sichuan Province, Chengdu, Sichuan, China (mainland) State Key Laboratory of Phytochemistry and Plant Resources in West China and CAS Center for Excellence in Molecular Plant Sciences, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China Central Laboratory Beijing Obstetrics and Gynecology Hospital Capital Medical University Beijing Maternal and Child Health Care Hospital Beijing China Cancer Biology Research Center (Key Laboratory of the Ministry of Education) Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan Hubei China; Department of Gynecologic Oncology Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan Hubei China The Third Department of Orthopedics, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province 510405, China Jiangsu Academy of Environmental Industry and Technology Corp.; Nanjing 210036; China; Ministry of Education Key Laboratory of Integrated Regulation and Resource Development on Shallow Lakes; College of Environment Key Laboratory for Anisotropy and Texture of Materials (Ministry of Education), School of Material Science and Engineering, Northeastern University, Shenyang 110819, China State Key Laboratory of Rice Biology and Ministry of Agriculture Key Laboratory of Agricultural Entomology, Institute of Insect Sciences Zhejiang University Hangzhou China College of Chemistry, Chemical Engineering and Materials Science, Soochow University, 199 Renai Road, Suzhou 215123, P. R. China State Key Laboratory of Chemical Resource Engineering; Key Laboratory of Carbon Fiber and Functional Polymers; Ministry of Education; Beijing Laboratory of Biomedical Materials; Beijing University of Chemical Technology Institute of Advanced Wear & Corrosion Resistant and Functional Materials, Jinan University, Guangzhou 510632, China Department of Obstetrics and Gynecology, The First Affiliated Hospital, Sun Yat‑sen University, Guangzhou, Guangdong 510086, P.R. China Dr. Phillip Frost Department of Dermatology & Cutaneous Surgery University of Miami Miller School of Medicine P.O. Box 016250 (R 250) Miami Florida, 33136 1Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia.; 2Department of Gynecology, Xiangya Hospital, Central South University, Changsha, Hunan, China. From the Hefei National Laboratory for Physical Sciences at the Microscale, Key Laboratory of Brain Function and Disease of Chinese Academy of Science, Department of Biophysics and Neurobiology, University of Science and Technology of China, Hefei, China (W.Y., L.M., T.S., Y.W., Jie Li, C.C., Z.F., Y.M., W.T., Juan Li, Z.Z.); the Department of Psychology, Anhui Mental Health Center, Hefei, China The College of Sciences; Henan Agricultural University; Zhengzhou 450002; P. R. China Department of Oncology Beijing Chest Hospital Capital Medical University Beijing China Emegency Department Beijing Fuxing Hospital, Capital Medical Universtiy Beijing China Medical College of Soochow University, Suzhou, China Hepatobiliary Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China; Key Laboratory of Liver Transplantation, Chinese Academy of Medical Sciences, Nanjing 210029, China; NHC Key Laboratory of Living Donor Liver Transplantation, Nanjing Medical University, Nanjing 210029, China School of Environmental Science and Engineering, Sun Yat-sen University, Guangzhou 510275, China. muzijie081@163.com State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing 210023, China; China-Russia Joint Laboratory of Plasma Technologies, Laser Institute of Shandong Academy of Sciences, Jining 27000, China Department of Cellular Biophysics, Max Planck Institute for Medical Research, Jahnstraße 29, 69120 Heidelberg, Germany; Department of Biophysical Chemistry, Heidelberg University, INF 253, 69120 Heidelberg, Germany Department of Orthopaedic Surgery, Ningbo Medical Center Li Huili Hospital, Ningbo, 315100 Zhejiang, China State Key Laboratory of Membrane Biology and Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Institute of Molecular Medicine College of Future Technology Peking University Beijing China; Peking‐Tsinghua Center for Life Sciences Peking University Beijing China; PKU‐IDG/McGovern Institute for Brain Research Peking University Beijing China *Department of Neurology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China; JC Wilt Infectious Disease Research Centre Office of Surveillance and Epidemiology, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, MD Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, 500 W. 12th Avenue, Columbus, Ohio 43210, United States National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China Department of Hematology, Hebei General Hospital, Shijiazhuang, Hebei 050051, P.R. China Institute of Organic Luminescent Materials (IOLM) College of Chemistry Liaoning University 66 Chongshan Mid. Road Shenyang 110036 China State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing 210023, China Institute of Chemistry for Functionalized Materials School of Chemistry and Chemical Engineering Liaoning Normal University Dalian 116029 China CAS Key Laboratory of Nanosystem and Hierarchical Fabrication National Center for Nanoscience and Technology Beijing 100190 P. R. China Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China Guangdong Key Laboratory of Ornamental Plant Germplasm Innovation and Utilization , Environmental Horticulture Research Institute, , Guangzhou 510640 , China; Guangdong Academy of Agricultural Sciences , Environmental Horticulture Research Institute, , Guangzhou 510640 , China Department of Hematology, Hebei General Hospital, Shijiazhuang, Hebei 050000, P.R. China Key Laboratory for Organic Electronics and Information Displays, Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing University of Posts & Telecommunications, 9 Wenyuan Road, Nanjing 210023, China Advanced Water Management Centre, Faculty of Engineering, Architecture and Information Technology, The University of Queensland , Brisbane, QLD, Australia Dermatology Department, The Second Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, China 1Genomics Institute of the Novartis Research Foundation, San Diego, California. Department of Chemistry, Institute for Advanced Study, State Key Laboratory of Molecular Neuroscience, Institute of Molecular Functional Materials and Division of Biomedical Engineering, Institute of Molecular Functional Materials, The Hong Kong University of Science and Technology (HKUST), Kowloon, Hong Kong, China State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing, PR China; College of Life Sciences, University of Chinese Academy of Sciences, Beijing, PR China Intelligent Network Research Institute Zhejiang Lab Hangzhou 311100 P. R. China College of Ocean Food and Biological Engineering Jimei University Xiamen Fujian 361021 P. R. China Department of Pediatrics, The Johns Hopkins University School of Medicine, Baltimore, Maryland.; Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland. Department of Biochemistry and Metabolism, The John Innes Centre, Norwich Research Park Norwich NR4 7UH UK Department of Gynecolgy and Obstetrics, General Hospital of PLA, Beijing 100853, China. gengjieli@126.com College of Architecture and Environment, Sichuan University, No. 24, South Section 1, First Ring Road, Chengdu, Sichuan 610065, China State Key Laboratory for Mechanical Behaviour of Materials, Xi’an Jiaotong University, Xi’an710049P. R. China Department of Nephrology, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui Central Hospital, Lishui, Zhejiang, China School of Information Science and Technology; University of Science and Technology of China; Hefei; China Department of Gastrointestinal Oncology Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education) Peking University Cancer Hospital and Institute Beijing China Department of Laboratory Medicine , Peking University Shenzhen Hospital , Lianhua Road No. 1120, Futian District , Shenzhen, Guangdong , P.R. China , Phone: +86-0755-83923333-2295 Chinese Academy of Sciences (CAS) Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, China.; University of Chinese Academy of Sciences, Beijing 100049, China.; CAS Key Laboratory of Nanosystem and Hierarchical Fabrication, National Center for Nanoscience and Technology, Beijing 100190, China. State Key Laboratory of Phytochemistry and Plant Resources in West China and CAS Center for Excellence in Molecular Plant Sciences, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People’s Republic of China; University of the Chinese Academy of Sciences, Beijing 100049, People’s Republic of China Department of Orthopaedics and Traumatology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, Hong Kong State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China Tianjin Key Laboratory of Molecular Optoelectronic Sciences, Department of Chemistry, Institute of Molecular Aggregation Science, Tianjin University, Tianjin 300072, China Department of Radiation Oncology, Biologic Therapeutics Center, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8224, St. Louis, Missouri 63110, United States Department of Ophthalmology, The Affiliated Xuzhou Municipal Hospital of Xuzhou Medical University, Xuzhou First People's Hospital, Eye Institute of Xuzhou, Jiangsu, China; and Gardening Research Institute, Shanxi Academy of Agricultural Science, Taiyuan, Shanxi, China, and Cancer Centre and Institute of Translational Medicine Faculty of Health Sciences University of Macau Macau SAR 999078 China College of Materials Science and Engineering, Zhejiang University of Technology, Hangzhou, 310014, P. R. China 3University of California, San Diego, La Jolla, California. Department of Ophthalmology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China; Institutes of Physical Science and Information Technology Key Laboratory of Structure and Functional Regulation of Hybrid Materials of Ministry of Education Key Laboratory of Environment-Friendly Polymeric Materials of Anhui Province Anhui University Hefei Anhui 230601 China Center for Organic Photonics and Electronics Research (OPERA) and ‡Institute for Materials Chemistry and Engineering, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan College of Stomatology, Chongqing Medical University, Chongqing, China Engineering Research Center for Molecular Diagnosis, Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming650500, Yunnan, People’s Republic of China Department of Emergency, Beijing Fu-Xing Hospital, Capital Medical University, Beijing, China. College of Pharmacy, Jinan University, Guangzhou 510632, China Institute of Medicine Plants, Yunnan Academy of Agricultural Sciences, Kunming 650200, P. R. China; College of Traditional Chinese Medicine, Yunnan University of Traditional Chinese Medicine, Kunming 650500, P. R. China Department of Orthodontics, Hebei Key Laboratory of Stomatology, Hebei Clinical Research Center for Oral Diseases, School and Hospital of Stomatology, Hebei Medical University, Shijiazhuang 050017, PR China School of Food and Biological Engineering, Jiangsu University, 301 Xuefu Road, Zhenjiang, Jiangsu 212013, China Hefei National Laboratory for Physical Sciences at the Microscale; CAS Key Laboratory of Materials for Energy Conversion; Department of Materials Science and Engineering; University of Science and Technology of China; Hefei 230026 State Key Laboratory of Grassland Agro-Ecosystems, College of Pastoral Agriculture Science and Technology, Lanzhou University, Lanzhou, China. Department of Orthopaedics, Affiliated Hospital of Nanyang Higher Medical School, Nanyang 473058, Henan, China. Department of General Surgery, Yancheng City No. 1 People's Hospital, Yancheng, Jiangsu 224005, P.R. China Shandong University of Traditional Chinese Medicine, Jinan, China; Second Affiliated Hospital of Shandong University of TCM, Jinan, China Center for AIE Research Shenzhen Key Laboratory of Polymer Science and Technology College of Materials Science and Engineering Shenzhen University Shenzhen 518060 China; Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province College of Physics and Optoelectronic Engineering Shenzhen University Shenzhen 518060 China; Beijing National Laboratory for Molecular Sciences (BNLMS) College of Chemistry and Molecular Engineering Peking University Beijing 100871 China State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, People's Republic of China General Practice Department of Nanchong North, Sichuan Medical College, Nanchong, P.R. China College of Chemistry and Chemical Engineering Xinyang Normal University Xinyang 464000 People's Republic of China Guangxi Reproductive Medical Research Center First Affiliated Hospital of Guangxi Medical University, Guangxi Zhuang Autonomous Region China Department of Neurosurgery, Tongren Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China The Second Affiliated Hospital of Shandong First Medical University, No. 366 Taishan Street, Tai’an, Shandong 271000, China Pearl River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Guangzhou, People’s Republic of China and; Experimental Station for Scientific Observation on Fishery Resources and Environment in the Middle and Lower Reaches of Pearl River, Ministry of Agriculture, Guangzhou, People’s Republic of China School of Mechatronical Engineering, Beijing Institute of Technology, Beijing, China Third Hospital of Hebei Medical University, Shijiazhuang, China; Key Orthopaedic Biomechanics Laboratory of Hebei Province, Shijiazhuang, China Department of Surgery, Division of Hepatobiliary and Pancreatic Surgery the First Affiliated Hospital, Zhejiang University School of Medicine Hangzhou China; NHFPC Key Laboratory of Combined Multi‐organ Transplantation Hangzhou China State Key Laboratory of Fine Chemicals Dalian University of Technology Linggong Road 2 Dalian 116024 P. R. China State Key Laboratory of Veterinary Etiological Biology, Key Laboratory of Veterinary Parasitology of Gansu Province, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu Province, People's Republic of China; College of Veterinary Medicine, South China Agricultural University, Guangzhou, Guangdong Province, People's Republic of China School of Material Science and Engineering, University of Jinan, 250022, Jinan, China Department of Gastrointestinal Oncology, Peking University School of Oncology, Beijing Cancer Hospital & Institute, Beijing 100142, China. Pearl River Fisheries Research Institute Chinese Academy of Fishery Science Guangzhou China; Key Laboratory of Aquatic Animal Immune Technology of Guangdong Province Guangzhou China; Guangzhou Scientific Observing and Experimental Station of National Fisheries Resources and Environment Guangzhou China Department of Ultrasound Qilu Hospital of Shandong University Jinan China Division of Epidemiology, Office of Pharmacovigilance and Epidemiology, Office of Surveillance and Epidemiology, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland State Key Laboratory of Plant Cell and Chromosome Engineering, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research School of Medicine Lishui Hospital of Zhejiang University Lishui China; Department of Radiology the Fifth Affiliated Hospital of Wenzhou Medical University Affiliated Lishui Hospital of Zhejiang University The Central Hospital of Zhejiang Lishui Lishui China Department of Transfusion Medicine, The Fifth Central Hospital of Tianjin, Tianjin 300450, P.R. China Department of Anatomy and HistologySchool of Basic Medical Sciences Tianjin China; Tianjin Economic-Technological Development AreaInternational Cardiovascular HospitalChinese Academy of Medical SciencesPeking Union Medical College Tianjin China Key Laboratory for the Physics and Chemistry of Nanodevices and Center for Carbon-based Electronics, Department of Electronics, Peking University, Beijing 100871, China Department of Gastrointestinal Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, P.R. China Department of Neurology The Second Affiliated Hospital of Harbin Medical University Harbin Heilongjiang China Laboratory of Allergy and Clinical Immunology, Department of Immunology, Institute of Allergy and Immune-related Diseases, Centre for Medical Research, Wuhan University School of Medicine, Wuhan, People's Republic of China Key Laboratory of Pesticide & Chemical Biology of Ministry of Education, Institute of Environmental & Applied Chemistry, College of Chemistry, Central China Normal University, Wuhan 430079, P. R. China Department of Hepatobiliary and Pancreatic Surgery,The First Affiliated Hospital of Zhengzhou University,Zhengzhou,Henan Province,China; Henan Key Laboratory of Digestive Organ Transplantation,Zhengzhou,Henan Province,China; Open and Key Laboratory of Hepatobiliary & Pancreatic Surgery and Digestive Organ Transplantation at Henan Universities,Zhengzhou,Henan Province,China National Key Discipline, Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, Harbin, China; Department of Epidemiology, Brown University, Providence, RI; Center for Global Cardiometabolic Health, Brown University, Providence, RI Beijing Institute of Basic Medical Sciences, Beijing, China. College of Animal Science and Technology, Anhui Agricultural University, Hefei 230036, China Department of Neurology, People's Hospital of Deyang City State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou, China. Department of Medicine, Cardiovascular Division, Brigham and Women’s Hospital, Harvard Medical School, Boston, United States Department of Neonatology, Children’s Hospital of Soochow University, Suzhou, Jiangsu 215003, China Research Institute of Pesticidal Design & Synthesis, College of Sciences, Northwest A&F University, Yangling, Shaanxi 712100, People’s Republic of China Anhui Advanced Building Materials Engineering Laboratory, Anhui Jian Zhu University, Hefei 230601, China; School of Materials and Chemical Engineering, Anhui Jian Zhu University, Hefei 230601, China School of Stomatology; Lanzhou University; Lanzhou 730000; PR China Center for Clinical Laboratory, Zhujiang Hospital, and Key Laboratory of Prevention and Control of Emerging Infectious Diseases of Guangdong Higher Education Institutes, Southern Medical University, Guangzhou, People's Republic of China State Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi 214122, China; School of Food Science and Technology, Jiangnan University, Wuxi 214122, China Department of Spleen and Stomach Diseases, The First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine, Nanning, Guangxi Zhuang Autonomous Region 530023, P.R. China Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province College Animal Science and Technology Northwest A&F University Yangling Shaanxi China Department of Nephrology Henan Provincial people's hospital Henan 450003 China Key Laboratory of Luminescent and Real-Time Analytical Chemistry, Ministry of Education, College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, P.R. China Beijing National Laboratory for Molecular Sciences CAS Key Laboratory of Organic Solids and Laboratory of Molecular Nanostructure and Nanotechnology Institute of Chemistry Chinese Academy of Sciences Beijing 100190 P. R. China; University of Chinese Academy of Sciences Beijing 100190 P. R. China Department of Breast Surgery Beijing Chao‐Yang Hospital Beijing China Institute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences 1 , Shanghai 200031 , China Reproductive Medicine Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China Key Laboratory of Chemical Sensing & Analysis in Universities of Shandong; School of Chemistry and Chemical Engineering; University of Jinan; Jinan; P. R. China School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou, Jiangsu 225002, China Key Laboratory of Functional Polymer Materials of Ministry Education, Institute of Polymer Chemistry, College of Chemistry, Nankai University, Tianjin 300071, China CAS Key Laboratory of Biofuels, Shandong Provincial Key Laboratory of Synthetic Biology, Shandong Engineering Laboratory of Single Cell Oil, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao 266101, China; Shandong Energy Institute, Qingdao 266101, China; Qingdao New Energy Shandong Laboratory, Qingdao 266101, China; University of Chinese Academy of Sciences, Beijing 100049, China School of Pharmacy, Binzhou Medical University, Yantai 264003, China Erythrocyte Biology Laboratory, School of Life Sciences, Zhengzhou University, Zhengzhou, China;; Laboratory of Membrane Biology, New York Blood Center, New York, NY; College of Energy and Power Engineering, Changsha University of Science & Technology, Changsha, 410114, China; Key Laboratory of Renewable Energy Electric-Technology of Hunan Province, Changsha, 410114, China Laboratory of Molecular Neural Biology, School of Life Sciences, Shanghai University, Shanghai, China Obstetrics and Gynecology Hospital, Institute of Reproduction and Development, Fudan University, Shanghai, China (L.G., X.L., F.G., J.L., Y.L., B.Z., C.Z., L.J., Y.W., H.H.). Department of Radiation Oncology Radiation Oncology Key Laboratory Of Sichuan Province Sichuan Cancer Hospital & Institute Chengdu Sichuan China State Key Laboratory of Chemical Resource Engineering, Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, Beijing 100029, P. R. China College of Materials Science and Engineering, North University of China, Taiyuan 030051, China. ajiestar@tom.com Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, Hefei, AH, China Department of Cardiology, Key Laboratory on Assisted Circulation, Ministry of Health The First Affiliated Hospital of Sun Yat‐sen University Guangzhou Guangdong People's Republic of China Key Laboratory of Organic Integrated Circuits, Ministry of Education, Tianjin Key Laboratory of Molecular Optoelectronic Sciences, Department of Chemistry, Institute of Molecular Aggregation Science, Tianjin University, Tianjin 300072, China Center for Circadian Clocks, Soochow University, Suzhou, Jiangsu, China; School of Biology & Basic Medical Sciences, Suzhou Medical College, Soochow University, Suzhou, Jiangsu, China Department of Acupuncture and Moxibustion, Shaanxi University of Chinese Medicine, Xi'an-Xianyang New Ecomic Zone, Xianyang City, Shaanxi Province, China The Guangxi Zhuang Autonomous Region Family Planning Research Center, Nanning, China Key Laboratory of Flexible Electronics (KLOFE) and Institute of Advanced Materials (IAM) Nanjing Tech University (NanjingTech) Nanjing China Department of Geriatrics, National Key Clinical Specialty, Guangzhou First People's Hospital, Guangzhou Medical University , Guangzhou 510000 , China; Department of Medicine, Cardiovascular Medicine, Brigham and Women’s Hospital and Harvard Medical School , 77 Avenue Louis Pasteur, NRB-7, Boston, MA 02115 , USA Cyrus Tang Hematology Center Jiangsu Institute of Hematology The First Affiliated Hospital Soochow University Suzhou China Department of Nephrology, Traditional Chinese Internal Medicine e-Institute of Shanghai University, ShuGuang Hospital, Shanghai University of Traditional Chinese Medicine, PR China Department of Chemistry, School of Pharmacy, Xuzhou Medical College, Xuzhou, 221004, China Department of Cardiovascular Surgery, First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China. The Reproductive Hospital of Guangxi Zhuang Autonomous Region, Nanning, China College of Materials Science and Engineering Institute of Hybrid Materials Qingdao University Qingdao 266071 P. R. China Department of Pathology, Basic Medical College, Fourth Military Medical University, Xi'an 710032, China. Department of Orthopedics, the First Affiliated Hospital of Fujian Medical University, Fuzhou Fujian, 350004, P.R.China. Department of Gastrointestinal Oncology Key Laboratory of Carcinogenesis and Translational Research Ministry of Education Peking University Cancer Hospital and Institute Beijing China Glycochemistry & Glycobiology Lab, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203, People’s Republic of China CAS Key Laboratory of Receptor Research, Synthetic Organic & Medicinal Chemistry Laboratory, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China; ShanghaiTech University, Shanghai 20120, China School of Biomedical Sciences and Engineering, Guangzhou International Campus, South China University of Technology, Guangzhou 511442, China Department of Psychological Medicine, Tianjin Anding Hospital, Tianjin, China Key Laboratory for Micro/Nano Optoelectronic Devices of Ministry of Education & Hunan Provincial Key Laboratory of Low-Dimensional Structural Physics and Devices, School of Physics and Electronics, Hunan University, Changsha 410082, China Department of Breast and Thyroid Surgery, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China Department of General Medical Ward, the First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Department of Ophthalmology, University of Florida, Gainesville, Florida School of Nursing Shandong University Shandong China Department of Obstetrics and Gynecology, the Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China The First Affiliated Hospital, Chongqing Medical University, Chongqing, P.R. China Department of Infectious Diseases, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Jiangsu, China;; Institute of Viruses and Infectious Diseases, Nanjing University, Jiangsu, China; Key Laboratory of Guangzhou Environmental Pollution and Risk Assessment; Department of Toxicology; School of Public Health; Sun Yat-sen University; Guangzhou Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of Coronary Disease, Guangdong General Hospital, Guangdong Academy of Medical Sciences, School of Medicine, South China University of Technology, Guangzhou, China CAS Key Laboratory of Nanophotonic Materials and Devices & Key Laboratory of Nanodevices and Applications, i-Lab, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou 215123, P. R. China Department of Infectious Diseases Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University Nanjing Jiangsu China; Department of Infectious Diseases Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine Nanjing Jiangsu China; Department of Infectious Diseases Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University Nanjing Jiangsu China; Department of Gastroenterology Shandong Provincial Hospital, Shandong University Jinan Shandong China Department of Urology, Tianjin Institute of Urology, The Second Hospital of Tianjin Medical University, Hexi, Tianjin 300211, P.R. China School of Medical Engineering; Hefei University of Technology; Hefei; People's Republic of China School of Materials Engineering; Shanghai University of Engineering Science; Shanghai 201620; China Institute of Viruses and Infectious Diseases, Nanjing University, Nanjing, People’s Republic of China; Department of Infectious Diseases, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, People’s Republic of China Department of Cardiology, People's Hospital of Xinjiang Uygur Autonomous Region School of Chemistry and Materials Science, Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials, Jiangsu Normal University, Xuzhou 221116, P. R. China State Key Laboratory of Soil and Sustainable Agriculture, Institute of Soil Sciences, Chinese Academy of Sciences, Nanjing 210008, China. jieli@issas.ac.cn National Research Center for Conservation of Ancient Wall Paintings and Earthen Sites, Department of Conservation Research, Dunhuang Academy, Dunhuang 736200, China; Gansu Provincial Research Center for Conservation of Dunhuang Cultural Heritage, Dunhuang Academy, Dunhuang 736200, China Department of Traumatic Orthopedics, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China McGraw-Hill Education, Monterey, CA, USA School of Nursing, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China; School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China College of Life Science, Northeast Agricultural University, Harbin, China BGI Education Center, University of Chinese Academy of Sciences, Shenzhen, China.; BGI-Shenzhen, Shenzhen, China. Department of Pathology Linyi People's Hospital Linyi Shandong Province China Division of Basic Biomedical Sciences, University of South Dakota Sanford School of Medicine, Vermillion, SD (P.X., C.W., J. Li, H.S., L.Y., P.W., M.T.L., X.W.).; Vascular Biology Center and Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta University, Augusta, GA (J. Li, H.S.). Department of Radiation Oncology, Sichuan Cancer Hospital, Chengdu, Sichuan, China Center for Theoretical and Applied Neuro-Oncology, Division of Neurosurgery, University of California, San Diego Protein Science Laboratory of the Ministry of Education, School of Life Sciences, Tsinghua University, Beijing 100084, China; National Engineering Laboratory for Anti-tumor Protein Therapeutics, School of Life Sciences, Tsinghua University, Beijing 100084, China Department of Oncology, The First Affiliated Hospital of Chongqing Medical University, Yuzhong, Chongqing 400016, P.R. China Department of Urology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China Department of Endocrinology, The Third People's Hospital of Datong, Datong, China College of Animal Science and Technology, Innovation Experimental College, Northwest A&F University, Xi'an, Shaanxi, China Department of Ultrasound, Qilu Hospital of Shandong University, Jinan College of Food Science Fujian Agriculture and Forestry University Fuzhou China Department of Dermatology, Xiangya Hospital, Central South University, Changsha 410008. xylijie@csu.edu.cn. Hunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Central South University, Changsha 410008. xylijie@csu.edu.cn. National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410008, China. xylijie@csu.edu.cn. Department of Gerontology Shanghai Jiao Tong University Affiliated Sixth People's Hospital Shanghai P. R. China Department of Anatomy and Histology, School of Basic Medical Sciences Tianjin Medical University Tianjin China Department of Geriatrics, Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University, Shanghai 200233, China Division of Gastroenterology-Hepatology, Department of Internal Medicine, University of Iowa, Iowa City, Iowa 52242 Administration of Sports of Guangdong Province, Guangzhou, Guangdong, 510105, China Department of Ultrasound, Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School Nanjing Jiangsu China Department of Chemistry, Wayne State University, Detroit, Michigan 48202, and Department of Organic Chemistry and the Lise Meitner-Minerva Center of Computational Chemistry, Hebrew University, Jerusalem 91904, Israel Department of Clinical Laboratory, The Second Affiliated Hospital of Henan University of Science and Technology, Luoyang, Henan, China Physical and Chemical Analysis laboratory; Division of Material Science & Quality Test; Shanghai Institute of Measurement and Testing Technology; Shanghai 201203; China Department of Chemistry and Biochemistry and Department of Biology, Utah State University, 0300 Old Main Hill, Logan, Utah 84322-0300 College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, China Department of Surgery, Faculty of Medicine and Dentistry, College of Health Sciences, University of Alberta, Edmonton, AB T6G 2S2, Canada Key Laboratory of Animal Epidemiology of the Ministry of Agriculture, College of Veterinary Medicine, and State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing, People's Republic of China Department of Environmental Science and Engineering, College of Chemical Engineering, Beijing University of Chemical Technology, Beijing 100029, People’s Republic of China Chengdu University of TCM International Joint Research Center on Purinergic Signaling of Sichuan Province, , Chengdu 610075 , China; Chengdu University of TCM School of Acupuncture and Tuina, , Chengdu 610075 , China State Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing 10091, China; National Clinical Research Center for Obstetrics and Gynecology, Peking University Third Hospital, Beijing 10091, China Transfusion Department Henan Science & Technology University No. 2 Affiliated Hospital Luoyang China Shijiazhuang Information Engineering Vocational College, Shijiazhuang 050000, China State Key Laboratory of Oral Diseases, West China Hospital of Stomatology; Sichuan University; Chengdu China; National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology; Sichuan University; Chengdu China Department of Medical Affairs, Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China Department of Spine Surgery, the Second Hospital of Tangshan, Tangshan City, Hebei Province, China. Institute of Animal Husbandry and Veterinary Science Henan Academy of Agricultural Sciences Zhengzhou China Department of Urban Planning and Design, Xi’an Jiaotong-Liverpool University, Suzhou, China Department of Neurosurgery University of Minnesota Minneapolis Minnesota *Department of Geology, University of Illinois at Urbana–Champaign, 1301 West Green Street, Urbana, IL 61801; and Department of Stomatology Shandong Provincial Qianfoshan Hospital Jinan China Department of Plastic Surgery Affiliated Friendship Plastic Surgery Hospital of Nanjing Medical University, Nanjing Medical University Nanjing China Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China Department of Cardiology, Vascular Center, Guangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China Beijing Center for Disease Control and Prevention, Beijing City, China NHC Key Laboratory of Nuclear Technology Medical Transformation, Department of Oncology, Mianyang Central Hospital, Mianyang, People's Republic of China Division of Spine Surgery, Department of Orthopedic Surgery Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School Nanjing China Tianjin Key Laboratory of Ionic‐Molecular Function of Cardiovascular Disease Department of Cardiology Tianjin Institute of Cardiology Second Hospital of Tianjin Medical University Tianjin China; VIP Department Qingdao Municipal Hospital Shandong China Sugarcane Research Institute of Yunnan Academy of Agricultural Sciences, Kaiyuan, 661699, Yunnan, China Institute of Space Medico-Engineering, Beijing, China. Department of Laboratory Medicine, Peking University Shenzhen Hospital, Shenzhen, People’s Republic of China Guangdong School of Energy and Power Engineering, Changsha University of Science & Technology, Changsha, 410114, China; Key Laboratory of Renewable Energy Electric-Technology of Hunan Province, Changsha, 410114, China Department of Environmental Health, Shandong University, Jinan, China; Department of Epidemiology and Center for Global Cardiometabolic Health School of Public Health, Brown University Providence Rhode Island USA; Departments of Surgery and Medicine, The Warren Alpert Medical School Brown University Providence USA; Global Health Research Center Guangdong Provincial People's Hospital Guangdong Academy of Medical Sciences Guangzhou China Department of Orthopaedics, Xuzhou Central Hospital, Xuzhou Clinical School of Xuzhou Medical University, Xuzhou Clinical College of Nanjing Medical University, Xuzhou, China College of Food Science Fujian Agriculture and Forestry University Fuzhou Fujian China Key Laboratory of Interface Science and Engineering in Advanced Materials of Ministry of Education, College of Materials Science and Engineering of Taiyuan University of Technology, Taiyuan 030024, China. ajiestar@tom.com Department of Oncology, The 900th Hospital of the Chinese People's Liberation Army Joint Logistic Support Force, Fuzong Clinical College of Fujian Medical University, Fuzhou, Fujian 350025, P.R. China Collaborative Innovation Center for Advanced Ship and Deep-Sea Exploration, State Key Laboratory of Ocean Engineering, Shanghai Jiao Tong University 1 , Shanghai 200240, China Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research; Lishui Hospital of Zhejiang University; School of Medicine; Lishui 323000; China Central Laboratory Beijing Obstetrics and Gynecology Hospital Capital Medical University Capital Medical University Beijing China Department of Colorectal Surgery The First Affiliated Hospital of Nanjing Medical University Nanjing China Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, China Department of Ophthalmology, Hospital of University of Electronic Science and Technology of China and Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan 610072, China Tianjin Key Laboratory of Molecular Optoelectronic Sciences, Department of Chemistry, Institute of Molecular Aggregation Science, Tianjin University, Tianjin 300072, China. Department of Radiation Oncology, Sichuan Cancer Hospital, Renmin South Road 4th Section, No. 55, Chengdu 610041, China Zhejiang Provincial Key Laboratory of Chemical Utilization of Forestry Biomass, College of Chemistry and Materials Engineering, Zhejiang A&F University, Hangzhou311300, China Department of Pathology, Yale School of Medicine, New Haven, CT 06510, USA. Center for Integrative Conservation Xishuangbanna Tropical Botanical Garden Chinese Academy of Sciences Kunming 650223 China Department of Respiratory Medicine, Dongzhimen Hospital of Beijing University of Chinese Medicine, Beijing 100700, China Department of Cardiology, the Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China Department of Urology First Affiliated Hospital of Nanjing Medical University Nanjing China Center of Precision Medicine and Healthcare, Tsinghua-Berkeley Shenzhen Institute, Shenzhen, Guangdong 518055, China; Kunming Dog Base of Police Security, Ministry of Public Security, Kunming, Yunnan 650204, China Key Laboratory of Tropical Biological Resources of Ministry of Education, School of Pharmaceutical Sciences, Hainan University, Haikou, China State Key Laboratory of Quality Research in Chinese Medicines, Faculty of Chinese Medicine, Macau University of Science and Technology, Macau 999078, China; College of Pharmacy, Hangzhou Normal University, Hangzhou 311121, China; School of Environmental and Chemical Engineering, Zhaoqing University, Zhaoqing 526061, China College of Chemistry and Chemical Engineering, Qingdao University, Qingdao 266071, Shandong, P. R. China Zhejiang Provincial Engineering Technology Research Center of Marine Biomedical Products, School of Food and Pharmacy Zhejiang Ocean University Zhoushan China Department of Radiation Oncology Radiation Oncology Key Laboratory of Sichuan Province Sichuan Cancer Hospital & Institute Chengdu China Department of Oncology and Hematology, Liuyang Hospital of Traditional Chinese Medicine, Hunan University of Chinese Medicine, Changsha, China The Second Hospital of Hebei Medical University, No. 215 Heping Road (West), Shijiazhuang City, Hebei Province, China Department of Surgery Shandong Provincial Qianfushan Hospital 250012 Jinan Shandong China School of Chemical Science and Engineering, and Shanghai Key Lab of Chemical Assessment and Sustainability, Tongji University, 1239 Siping Road, Shanghai 200092, China Henan Natural History Museum, Zhengzhou, China Department of Nephrology, Zhuzhou Hospital Affiliated to Xiangya Medical College, Central South University, Zhuzhou, Hunan, China Clinical Medicine School of Ningxia Medical University, Yinchuan 750004, Ningxia Hui Autonomous Region, China. Beijing Chest Hospital Capital Medical University Beijing China Department of Ophthalmology, Sichuan Provincial People’s Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China State Key Laboratory of Drug Research & Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China; University of Chinese Academy of Sciences, Beijing 100049, China Division of Neurosurgery, Center for Theoretic and Applied Neuro-Oncology, Moores Cancer Center, University of California, San Diego, La Jolla, California. Department of Infectious Diseases, Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine; Department of Infectious Diseases, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University; Institute of Viruses and Infectious Diseases, Nanjing University; Department of Infectious Diseases, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing Guang’anmen Hospital, Chinese Academy of Chinese Medical Sciences, Beijing 100053, China Department of Respiratory Medicine, The Third People's Hospital of Kunming, Yunnan, 650041, People's Republic of China Key Laboratory of Green Fabrication and Surface Technology of Advanced Metal Materials, Ministry of Education, Anhui University of Technology, Maanshan 243002, PR China; Key Laboratory of Construction Hydraulic Robots of Anhui Higher Education Institutes, Tongling University, Tongling 244002, PR China School of Life Sciences, Northeast Normal University, Changchun 130024, China; Glycochemistry & Glycobiology Lab, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China Department of Obstetrics Affiliated Hospital of Weifang Medical University Weifang China Center of Marine Biotechnology and Biomedicine Scripps Institution of Oceanography University of California at San Diego 9500 Gilman Drive La Jolla CA 92093-0204 USA Institute of Electrostatics and Special Power, Dalian University of Technology, Dalian 116024, PR China; Key Laboratory of Industrial Ecology and Environmental Engineering, Ministry of Education of the People’s Republic of China, Dalian 116024, PR China Key Laboratory of Pesticide & Chemical Biology of Ministry of Education; Institute of Environmental Chemistry; College of Chemistry; Central China Normal University; Wuhan 430079, P. R. China Department of Cellular Biophysics Max Planck Institute for Medical Research Jahnstraße 29 Heidelberg 69120 Germany; Department of Biophysical Chemistry Heidelberg University INF 253 Heidelberg 69120 Germany Department of Respiratory Medicine, The Affiliated Jiangyin Hospital of Southeast University Medical College Jiangyin, jiangsu, China. Hefei National Laboratory for Physical Sciences at the Microscale, CAS Key Laboratory of Materials for Energy Conversion, Department of Materials Science and Engineering, University of Science and Technology of China, Hefei, Anhui 230026, China State Key Laboratory of Electronic Thin Film and Integrated Devices, University of Electronic Science and Technology of China, Chengdu 610054, China Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033 Key Laboratory for the Physics and Chemistry of Nanodevices and Center for Carbon-based Electronics; Department of Electronics; Peking University; Beijing 100871; China From the Departments of Ophthalmology and Department of Breast and Thyroid Surgery, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China Department of Neurology, the Fourth Affiliated Hospital, China Medical University, Shenyang, 110032, China State Key Laboratory Cultivation Base of Natural Gas Conversion School of Chemistry & chemical engineering Ningxia University Yinchuan 750021 PR China Henan Key Laboratory of Polyoxometalates; Institute of Molecular and Crystal Engineering; College of Chemistry and Chemical Engineering; Henan University; Kaifeng 475004 Department of General Surgery, Qianfoshan Hospital, Shandong University, Jinan, Shandong, China Department of Orthopedics, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, China The Second Department of Obstetrics Department of Neurology, State University of New York Downstate Medical Center, Brooklyn, New York, USA 4Department of Surgery, Washington University School of Medicine, St. Louis, Missouri Beijing National Laboratory for Molecular Sciences (BNLMS), College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China; Center for AIE Research, Shenzhen Key Laboratory of Polymer Science and Technology, College of Materials Science and Engineering, Shenzhen University, Shenzhen, Guangdong 518060, China State Key Laboratory for Reproductive Medicine and Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China Nanotechnology Innovation Station, National Institute for Materials Science, 1-2-1 Sengen, Tsukuba, Ibaraki 305-0047, Japan College Pharmacy,Chengdu University of Traditional Chinese Medicine Chengdu 611137,China. Innovation Institute of Chinese Medicine and Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, 250355, China Shandong Provincial Engineering and Technological Research Center for Liver Disease Prevention and Control, Jinan, China; Department of Infectious Disease, Shandong Provincial Hospital, Shandong First Medical University, Jinan, China Department of Medical Intensive Care Unit Maternal and Child Health Hospital of Hubei Province Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei 430070 P. R. China Department of Hand Surgery, Huashan Hospital, Fudan University, Shanghai, China Department of Infectious Diseases, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China Key Laboratory of Marine Bio-resources Sustainable Utilization, RNAM Center for Marine Microbiology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, PR China Department of Medicine Queen Mary Hospital The University of Hong Kong Hong Kong Hong Kong; Department of Infectious Disease Shandong Provincial Hospital Affiliated to Shandong University Shandong China Key Laboratory of Superlight Materials and Surface Technology Ministry of Education College of Materials Science and Chemical Engineering Harbin Engineering University Harbin 150001 China Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, China Department of Radiation Oncology, Shanxi Provincial Cancer Hospital, Taiyuan 030013, P.R.China. Program in Epithelial Biology, Stanford University School of Medicine, 269 Campus Drive, Room 2145, CA 94305, USA. State Key Laboratory of Isotope Geochemistry Guangzhou Institute of Geochemistry, Chinese Academy of Sciences Guangzhou 510640 China Vegetable Genetics and Breeding Laboratory, College of Horticulture, Anhui Agricultural University; Hefei 230036, China; Anhui Provincial Engineering Laboratory of Horticultural Crop Breeding, Hefei 230036, China Department of Physics and Chemistry Institute of Forensic Science Wuhan Public security Bureau 1 Menghu Road Wuhan 430015 Hubei China Department of Pharmacology Wuhan University School of Basic Medical Sciences Wuhan China No. 1 Department of Nutrition, Chinese People’s Liberation Army General Hospital, Beijing, China School of Materials Science and Engineering, Zhejiang Sci-Tech University, Hangzhou, 310018, China Eye Institute of Shandong First Medical University, Eye Hospital of Shandong First Medical University (Shandong Eye Hospital), State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, School of Ophthalmology, Shandong First Medical University, Jinan 250012, China Department of Clinical Laboratory, Shanghai Gongli Hospital, The Second Military Medical University, Pudong New Area, Shanghai, China Department of Pharmacy Shanghai Jiao Tong University Affiliated Sixth People's Hospital Shanghai 200233 China; School of Pharmacy Shanghai Jiao Tong University Shanghai 200240 China College of Plant Sciences, Jilin University, Changchun 130062, China Center for Cognition and Brain Disorders, the Affiliated Hospital, Hangzhou Normal University, Hangzhou, China; Institutes of Psychological Sciences, Hangzhou Normal University, Hangzhou, China Ocean University of China 1 College of Information Science and Engineering, , Qingdao 266100, China Beijing Center for Disease Prevention and Control, Beijing Research Center for Preventive Medicine, Beijing, China Department of Intervention, Affiliated Hospital of Jiangnan University, The Fourth People’s Hospital of Wuxi City, Jiangsu Province, 214062, China Department of Pharmacy, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, China Key laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Gastrointestinal Oncology, Peking University Cancer Hospital & Institute, Beijing, China The Second Clinical Medical College of Shanxi Medical University, Taiyuan, China 1 The State Key Laboratory of Pharmaceutical Biotechnology and Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology; 2 Department of Bioinformatics, University Medical Center Göttingen, Goldschmidtstrasse 1, D-37077 Göttingen, Germany Department of Infectious Diseases, Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School, Nanjing, Jiangsu, China;; Institute of Viruses and Infectious Diseases, Nanjing University, Nanjing, Jiangsu, China; School of Nursing, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China School of Materials Science & Engineering Qilu University of Technology (Shandong Academy of Sciences) Jinan 250353 China Jiangsu Key Laboratory for the Research and Utilization of Plant Resources, Institute of Botany, Jiangsu Province and Chinese Academy of Sciences (Nanjing Botanical Garden Mem. Sun Yat-Sen), Qian Hu Hou Cun No. 1, Nanjing 210014, China Renmin University of China, 59 Zhongguancun Street, 1007 Block D, Huixian Building, Haidian, Beijing 100872, China Video and Image Processing System Laboratory, School of Electronic Engineering, Xidian University, Xi'an, China Department of Pathology, Chinese PLA General Hospital, 28 Fuxing Road, Haidian District, Beijing, 100853, China Department of Dermatology, Xiangya Hospital of Central South University, Changsha, Hunan, China; Hunan Engineering Research Center of Skin Health and Disease, Xiangya Hospital of Central South University, Changsha, Hunan, China; Hunan Key Laboratory of Skin cancer and Psoriasis, Xiangya Hospital of Central South University, Changsha, Hunan, China Department of Pathology, General Hospital of PLA, Beijing 100853, China. Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149, China. Department of Gastrointestinal Oncology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Peking University Cancer Hospital and Institute, Beijing, China. State Key Laboratory of ASIC and System, Fudan University, Shanghai 201203, China Psychiatric‐Neuroimging‐Genetics and Comorbidity Laboratory (PNGC‐Lab) Tianjin Mental Health Center Tianjin Anding Hospital Tianjin China Department of Physics and Astronomy, University of California at Irvine , Irvine, CA , United States State Key Laboratory of Radiation Medicine and Protection, School of Radiological and Interdisciplinary Sciences (RAD-X), and Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, 199 Ren’ai Road, Suzhou 215123, P. R. China Shanghai Jiao Tong University Pain Research Center, Department of Anesthesiology, University of Cincinnati Medical Center, Cincinnati, Ohio School of Medicine University of Electronic Science and Technology of China Chengdu China College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, People's Republic of China Key Laboratory of Functional Polymer Materials of Ministry of Education, Institute of Polymer Chemistry, College of Chemistry, Nankai University, Tianjin 300071, China Department of Hepatobiliary Surgery, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China College of Traditional Chinese Medicine, Yunnan University of Traditional Chinese Medicine, Kunming, China; Institute of Medicine Plants, Yunnan Academy of Agricultural Sciences, Kunming, China. Department of Breast Surgery, Shanxi Provincial People’s Hospital, Taiyuan, P.R. China Henan Key Laboratory of Polyoxometalate Chemistry, College of Chemistry and Chemical Engineering, Henan University, Kaifeng 475004, P. R. China; School of Chemistry & Chemical Engineering, Zhoukou Normal University, Zhoukou, Henan 466001, P. R. China Department of Nursing, Shenzhen Hospital Southern Medical University Shenzhen China; School of Nursing Southern Medical University Guangzhou Guangdong China School of Public Health, Wannan Medical College, Wuhu 241002 China. 410376220@qq.com. New Jersey Department of Health, New Jersey State Cancer Registry , Trenton, NJ, USA Lunan Pharmaceutical Group Corporation, Linyi, Shandong 276006, China School for Radiological and Interdisciplinary Sciences (RAD-X) and Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou 215123, China HKUST-Shenzhen Research Institute; Shenzhen, China 518057; Department of Chemistry; Institute for Advanced Study; Division of Biomedical Engineering and Institute of Molecular Functional Materials The First School of Clinical Medicine Nanjing Medical University Nanjing China Institute of Fluid Physics, China Academy of Engineering Physics , Mianyang 621900, People’s Republic of China Department of Geriatrics, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu 210009, P.R. China Department of Respiratory and Critical Care, First Affiliated Hospital of Gannan Medical University a Department of Orthopedics, Xinqiao Hospital, Army Military Medical University, Chongqing, People's Republic of China School of Metallurgy and Environment; Central South University; Changsha; China National Engineering Laboratory for Oral Regenerative Medicine West China Hospital of Stomatology Sichuan University Chengdu 610041 China; Department of Oral and Maxillofacial Surgery West China School of Stomatology Sichuan University Chengdu 610041 China; Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences College of Stomatology Chongqing Medical University Chongqing 401147 China School of Mechanical Engineering Southeast University Nanjing China CAS Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China CAS Key Laboratory of Nanophotonic Materials and Devices & Key Laboratory of Nanodevices and Applications i‐Lab Suzhou Institute of Nano‐Tech and Nano‐Bionics (SINANO) Chinese Academy of Sciences Ruoshui Road 398 Suzhou Jiangsu 215123 P. R. China Key Laboratory of Superlight Material and Surface Technology of Ministry of Education, College of Material Science and Chemical Engineering, Harbin Engineering University, Harbin 150001, China; Key Laboratory for Green Chemical Technology of Ministry of Education, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China; Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin 300072, China Jingzhou Hospital of traditional Chinese Medicine, Jingzhou National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention/State Key Laboratory for Infectious Disease Prevention and Control, Beijing, and Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou, China School of Nursing, Shandong University, No. 44 Wenhua Xi Road, Jinan 250012, China Center for Stem Cell Research and Regenerative Medicine, Tulane University School of Medicine, New Orleans, LA, USA. LaCell LLC, New Orleans, LA, USA. National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, China. Power China Water Environment Governance; Shenzhen 518100; P. R. China Department of Electrical Engineering National University of Tainan Tainan City Taiwan Institute of STD/AIDS Prevention and Control, Beijing Center for Disease Prevention and Control, Beijing, China. 1Institute of Molecular and Cell Biology, Proteos, Singapore and Department of General Surgery Qianfoshan Hospital Shandong University Jinan Shandong 250014 China Department of Hepatobiliary Surgery, The First Affiliated Hospital, Xi’an Jiaotong University, Xi’an 710061, China Department of Respiratory, Anzhen Hospital of Capital Medical University,Beijing Cardiopulmonary Vascular Disease Research Institute, Beijing 100029, China. Kenneth S. Pitzer Center for Theoretical Chemistry, Department of Chemistry, University of California, Berkeley, CA, USA School of Management Shanghai University Shanghai China Information Materials and Device Applications Key Laboratory of Sichuan Provincial Universities, Chengdu University of Information Technology, Chengdu 610225, China Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research, Lishui Hospital of Zhejiang University, Lishui 323000, China Department of Metabolic Biology, John Innes Centre, Norwich Research Park, Norwich, UK Department of Gastroenterology, The First Affiliated Hospital of Xi’an Medical University School of Metallurgy & Environment, Central South University, 410083, Changsha, China Key Laboratory of Organic Optoelectronics and Molecular Engineering, Department of Chemistry, Tsinghua University, 100084 Beijing, China Department of Pathogenic Microbiology and Immunology, Medical School of Xi'an Jiaotong University, Xi'an, China. Institute of Optoelectronic Materials and Devices China Jiliang University Hangzhou China College of Chemistry and Materials Engineering, Quzhou University Department of Chest Surgery, General Hospital of Chinese People's Liberation Army, Beijing 100853, China. Tianjin Mental Health Institute, Anding Hospital , Tianjin , China Department of Otolaryngology Head and neck surgery Yongchuan Hospital of Chongqing Medical University Chongqing City China State Key Laboratory for Conservation and Utilization of Bio-resource in Yunnan and School of Ecology and Environmental Science, Yunnan University , Kunming , China Scripps Institution of Oceanography, University of California, San Diego, La Jolla, California, United States Thoracic Surgeon, Department of Thoracic Surgery, The Chinese PLA General Hospital, Beijing, 100853, China Department of Molecular Microbiology and Immunology, University of Southern California School of Medicine, Los Angeles, California Department of Hematology, Cancer Centre of Qilu Hospital of Shandong University, Jinan 250012, China. Department of Dermatology, Xiangya Hospital, Central South University, Changsha, 410008, China Department of Orthopaedics, Xuzhou Central Hospital, The Xuzhou School of Clinical Medicine of Nanjing Medical University Xuzhou, Jiangsu, China. State Key Laboratory of Reproductive Medicine, The Research Center for Bone and Stem Cells, Department of Anatomy, Histology and Embryology, Nanjing Medical University Nanjing, Jiangsu, China. Department of Nuclear Medicine and Huaxi MR Research Center (HMRRC), Functional and Molecular Imaging Key Laboratory of Sichuan Province and Frontiers Science Center for Disease Related Molecular Network, West China Hospital, Sichuan University, China State Key Laboratory of Plant Physiology and Biochemistry, College of Life Sciences, Zhejiang University, Hangzhou 310058, China College of Pharmacy Chengdu University of Traditional Chinese Medicine Chengdu Sichuan China Hepatobiliary and Liver Transplantation Department, The Affiliated Qianfoshan Hospital, Shandong University, No. 16766 Jingshi Road, Jinan, Shandong 250014, China Reproductive Medicine Center, Ningbo Women and Children's Hospital, Ningbo, Zhejiang 315012, China . Department of Obstetrics and Gynecology the Affiliated Drum and Tower Hospital of Medical School of Nanjing University Nanjing Jiangsu China State Key Laboratory of Chemo/Biosensing and Chemometrics College of Chemistry and Chemical Engineering Hunan University Changsha Hunan 410082 P. R. China Laboratory of Carcinogenesis & Translational Research for the Ministry of National Education, Department of GI Oncology, Peking University School of Oncology, Beijing Cancer Hospital & Institute, Beijing, 100142 China State Key Laboratory of Advanced Metallurgy, University of Science and Technology Beijing, Beijing 100083, China Weifang Medical College, Weifang, China; State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Shandong Eye Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Qingdao, China Department of Orthopaedics and Traumatology The Chinese University of Hong Kong Hong Kong SAR China CAS Key Laboratory of Low-Carbon Conversion Science and Engineering; Shanghai Advanced Research Institute; Chinese Academy of Sciences; Shanghai 201203; P. R. China Institute of Neuroscience and Department of Neurology of the Second Affiliated Hospital, NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University School of Medicine, Hangzhou 310058, China.; Center for Stem Cell and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou 310058, China. Laboratory of Membrane Biology, New York Blood Center, New York, NY; Beijing Center for Disease Control and Prevention, Beijing City, People’s Republic of China Department of Earth and Environmental Sciences, University of Michigan, Ann Arbor, MI 48109 Department of Thoracic Surgery; The General Hospital of PLA; Beijing China Medical Research Institute College of Pharmaceutical Sciences Southwest University Chongqing 400715 China School of Environment and Natural Resources, Renmin University of China, Beijing, 100872, China Department of Pediatric Internal Medicine, The First People’s Hospital of Kunshan Affiliated to Jiangsu University, Kunshan 215300, China From the Division of Basic Biomedical Sciences, Sanford School of Medicine of the University of South Dakota, Vermillion, SD (Z.T., H.Z., J.L., Y.L., H.S., X.W.); and the Department of Anatomy and Embryology, Wuhan University School of Medicine, Wuhan, Hubei, China (Z.T.). School of Life Sciences IDG/McGovern Institute for Brain Research at Tsinghua Tsinghua University Beijing 100084 China Department of Dermatology, Vascular Biology Institute, University of Miami School of Medicine, Miami, Florida Department of Clinical Laboratory, Shanghai Gongli Hospital, The Second Military Medical University, Pudong New Area, Shanghai 200135, China Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education College of Stomatology Chongqing Medical University Chongqing China Department of Chemistry and Biochemistry, Utah State University, 0300 Old Main Hill, Logan, Utah 84322-0300, and Department of Chemistry and Biochemistry, Brigham Young University, Provo, Utah 84602 Center for AIE Research, Shenzhen Key Laboratory of Polymer Science and Technology, Guangdong Research Center for Interfacial Engineering of Functional Materials, College of Materials Science and Engineering, Shenzhen University, Shenzhen, 518060, China Department of Laboratory Medicine , Peking University Shenzhen Hospital , Lianhua Road No. 1120 , Futian District, Shenzhen, Guangdong , P.R. China , Phone: +86-0755-83923333-2295 National Lab of Solid State Microstructure and Physics Department, Nanjing University, Nanjing 210093, China Department of Pathology, Chinese People's Liberation Army General Hospital, Beijing 100853, P.R. China Jiangsu Textile Quality Services Inspection Testing Institute Jiangsu 210007 China The Fourth Hospital of Jilin University, Changchun, People’s Republic of China Institute of Insect Sciences, Zhejiang University, Hangzhou 310058, China Department of Psychiatry, School of Medicine University of California San Diego La Jolla CA USA Department of Radiology, Breast Imaging Service, Memorial Sloan-Kettering Cancer Center, 300 E 66th St., New York, NY 10065, USA. Department of Epidemiology and Biostatistics, Anhui Medical University, Meishan Road 81, Hefei, China Department of Infectious Disease, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu 210008, China State Key Laboratory of Atmospheric Boundary Layer Physics and Atmospheric Chemistry, Institute of Atmospheric Physics, Chinese Academy of Sciences, Beijing 100029, China Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI, USA Chongqing Key Laboratory of Neurobiology Chongqing China; Institute of Neuroscience and the Collaborative Innovation Center for Brain Science Chongqing Medical University Chongqing China; Department of Neurology Yongchuan Hospital of Chongqing Medical University Chongqing China School of Chemistry and Chemical Engineering, Central South University, Changsha 410083 China Department of Breast and Thyroid Surgery, Guangzhou Women and Children's Medical Center, Guangzhou, Guangdong 510623, P.R. China School of Nursing Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei China Institute of AIDS Control and Prevention, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, China Department of Oncology, Changhai Hospital, Naval Medical University 168 Changhai Road, Shanghai 200433, P. R. China. College of Information Science & Electronic Engineering, Zhejiang University, Hangzhou 310027, China; International Joint Innovation Center, Zhejiang University, Haining 314400, China North University of China Key Laboratory of Instrumentation Science and Dynamic Measurement, Ministry of Education, , Taiyuan 030051, People’s Republic of China and National Key Laboratory for Electronic Measurement Technology, School of Instrument and Electronics, , Taiyuan 030051, People’s Republic of China; North University of China Key Laboratory of Instrumentation Science and Dynamic Measurement, Ministry of Education, , Taiyuan 030051, People’s Republic of China and National Key Laboratory for Electronic Measurement Technology, School of Instrument and Electronics, , Taiyuan 030051, People’s Republic of China Taizhou First People's Hospital, Taizhou, Zhejiang Province, China Department of Anaesthesia, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China (mainland) Key Laboratory of Coarse Cereal Processing (Ministry of Agriculture and Rural Affairs), Sichuan Engineering & Technology Research Center of Coarse Cereal Industralization, School of Food and Biological Engineering, Chengdu University, Chengdu 610106, China; Research Center for Plants and Human Health, Institute of Urban Agriculture, Chinese Academy of Agricultural Sciences, National Agricultural Science and Technology Center, Chengdu 610213, China School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou 510275, P.R. China Department of Medical Genetics, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, Guangdong, PR China Department of Hepatobiliary and Pancreatic Surgery The First Affiliated Hospital of Zhengzhou University Henan China; Open and Key Laboratory of Hepatobiliary & Pancreatic Surgery and Digestive Organ Transplantation at Henan Universities Henan China; Zhengzhou Key Laboratory of Hepatobiliary & Pancreatic Diseases and Organ Transplantation Henan China Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai, China State Key Laboratory of Drug Research & Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China State Key Laboratory of Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China School of Physics and Mechanical and Electrical Engineering, Hubei University of Education, Wuhan, 430074, China; Hubei Engineering Technology Research Center of Environmental Purification Materials, Institute of Materials Research and Engineering, Hubei University of Education, Wuhan, 430074, China From the Division of Basic Biomedical Sciences, Sanford School of Medicine of the University of South Dakota, Vermillion, SD (H.S., J.L, J.L, X.W.); Vascular Biology Center and Department of Pharmacology and Toxicology, Medical College of Georgia, Georgia Regents University, Augusta, GA (H.S., J.L.); Division of Molecular Cardiovascular Biology, The Heart Institute, Department of Pediatrics, The Cincinnati Children’s Hospital Medical Center, OH (H.O., J.R.); Department of Pathology and Laboratory... Blood Specialty, Hebei General Hospital, Shijiazhuang, China Department of Pathology University Hospitals Case Medical Center; and the Cleveland Ohio; Case Western Reserve University School of Medicine Cleveland Ohio. Department of Gastroenterology Changhai Hospital Second Military Medical University Shanghai China State Key Laboratory of Environmental Chemistry and Ecotoxicology; Research Center for Eco-Environmental Sciences; Chinese Academy of Sciences; Beijing 100085; China Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China; Open and Key Laboratory of Hepatobiliary & Pancreatic Surgery and Digestive Organ Transplantation at Henan Universities, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China; Zhengzhou Key Laboratory of Hepatobiliary & Pancreatic Diseases and Organ Transplantation, Zhengzhou, Henan, China Key Laboratory of Marine Bio-resources Sustainable Utilization, CAS, RNAM Center for Marine Microbiology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, PR China School of Physics and Wuhan National High Magnetic Field Center; Huazhong University of Science and Technology; Wuhan 430074; China Department of Ophthalmology, Sichuan Academy of Medical Sciences and Sichuan Provincial People’s Hospital, Chengdu 610072, China Department of Laparoscope Surgery The 986st Hospital of People's Liberation Army Air Force Xi'an P.R. China Department of Infectious Disease, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, No. 109 West College Road, Wenzhou 325027, Zhejiang, China Zhejiang Provincial Key Laboratory of Chemical Utilization of Forestry Biomass, College of Chemistry and Materials Engineering, Zhejiang A&F University, Hangzhou 311300, China Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Academy of Medical Sciences, South China University of Technology School of Medicine, Guangzhou, China Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, China College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, P.R. China Department of Obstetrics and Gynecology, Tianjin Medical University General Hospital, Tianjin, China State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116024, China School of Computer Science and Technology, Harbin Institute of Technology, P. R. China Department of Urology, the Fifth People’s Hospital of Dongguan, Dongguan, Guangdong Province, China Department of Oncology, Jining First People's Hospital, Jining, Shandong 272011, P.R. China Center for Nanochemistry Beijing Science and Engineering Center for Nanocarbons Beijing National Laboratory for Molecular Sciences (BNLMS) College of Chemistry and Molecular Engineering Peking University Beijing 100871 China School of Mechanical Engineering, Wuhan Polytechnic University, Wuhan, 430023, Hubei, China Department of Cardiology, Xijing Hospital, Air Force Medical University, Xi’an 710032, China Centre of Excellence for Soil Biology, College of Resources and Environment, Southwest University, Beibei, Chongqing, China Video and Image Processing System Laboratory, School of Electronic Engineering, Xidian University, Xi’an, China Fudan University Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R.�ChinaDepartment of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R.�China Medicine State Key Laboratory of Drug Research & Center of Pharmaceutics Shanghai Institute of Materia Medica Chinese Academy of Sciences Shanghai 201203 China Department of Medicine and Vascular Biology Center, Georgia Regents University, Augusta, Georgia College of Physical Science and Technology, Yangzhou University, Yangzhou 225002, China School of Medicine and Life Sciences, Zhejiang University City College, Hangzhou 310015, China. lijie@zucc.edu.cn State Key Laboratory of Drug Research & Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China Genome Center, University of California, Davis Department of Neurology, TaikangTongji (Wuhan) Hospital, Wuhan, Hubei, China Sichuan Runjie Hongda Aquatic Science and Technology Co. Ltd Chengdu China Key Laboratory for Heavy Metal Pollution Control and Reutilization; School of Environment and Energy; Peking University Shenzhen Graduate School; Shenzhen 518055; China Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing, Jiangsu, 210046, People’s Republic of China Department of Microbiology and Infectious Disease Center School of Basic Medical Sciences Peking University Health Science Center Beijing China Department of Energy Politecnico di Milano Via Lambruschini, 4 20156 Milano Italy Department of Breast Cancer, 307 Hospital, Academy of Military Medical Sciences, Beijing 100850, China. Department of Neurology Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei China College of Bioinformatics Science and Technology, Harbin Medical University Harbin Heilongjiang China College of Chemistry; Key Laboratory of Inorganic–Organic Hybrid Functional Material Chemistry; Ministry of Education; Tianjin Key Laboratory of Structure and Performance for Functional Molecules; Tianjin Normal University Key Laboratory of Interface Science and Engineering in Advanced Materials Ministry of Education Taiyuan University of Technology 030024 Taiyuan P. R. China Department of Breast Surgery Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (MOE), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, China Grünberg Research Centre, Nanjing University of Posts and Telecommunications, Nanjing 210003, China School of Nursing, Tongji Medical College, Huazhong University of Science and Technology Wuhan Hubei China Department of Chinese Materia Medica and Natural Medicines, Air Force Medical University, Xi'an, Shaanxi 710032, P.R. China Department of Infectious Diseases, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, Jiangsu 210008, China; Institute of Viruses and Infectious Diseases, Nanjing University, Nanjing, Jiangsu 210093, China School of Chemistry and Chemical Engineering, Wuhan Textile University, Hubei Key Laboratory of Biomass Fibers and Eco-dyeing & Finishing, Wuhan 430200, People's Republic of China School of Materials Science and Engineering; Beijing Institute of Technology; Beijing; China Department of Hepatobillary Surgery, Qianfoshan Hospital, Shandong University Jinan, 250014. Chongqing Key Lab for Advanced Materials and Clean Energies of Technologies, Southwest University, Chongqing, 400715, P. R. China; School of Materials and Energy, Southwest University, Chongqing, 400715, P. R. China School of Public Health, Anhui Medical University, Hefei. Beijing Key Laboratory of Photoelectronic/Electrophotonic Conversion Materials; Key Laboratory of Cluster Science; Ministry of Education; School of Chemistry and Chemical Engineering; Beijing Institute of Technology Center for Research on Heath Care Data Center, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, United States Key Laboratory of marine Bio-resources Sustainable Utilization CAS, RNAM Center for Marine Microbiology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, PR China; Key Laboratory for Microbial Diversity in Southwest China, Ministry of Education and Laboratory for Conservation and Utilization of Bio-resources, Yunnan Institute of Microbiology, Yunnan University, Kunming 650091, PR China State Key Laboratory of Bio-organic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences , Guangzhou, China State Key Laboratory of Materials-Oriented Chemical Engineering College of Biotechnology and Pharmaceutical Engineering Nanjing Tech University 30 Puzhu Road South Nanjing 211816 P.R. China Pathology Department, Chinese PLA General Hospital and Chinese PLA Medical School, Beijing, P.R. China College of Animal Sciences, Zhejiang University, Hangzhou, China; Ministry of Education, The Key Laboratory of Molecular Animal Nutrition, Hangzhou, China; Zhejiang Provincial Laboratory of Feed and Animal Nutrition, Hangzhou, China Department of the Endocrine and Breast Surgery The First Affiliated Hospital of Chongqing Medical University, Chongqing Medical University Chongqing China Department of Nephrology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China; Key Laboratory of Industrial Fermentation Microbiology, Ministry of Education, Tianjin Industrial Microbiology Key Laboratory, College of Biotechnology, Tianjin University of Science and Technology, Tianjin 300457, China Radiotherapy Department, Shaanxi Provincial Cancer Hospital, Xi'an, Shaanxi 710600, P.R. China Department of Chemistry; Institute for Advanced Study; Division of Life Science; Institute of Molecular Functional Materials; Division of Biomedical Engineering and State Key Laboratory of Molecular Neuroscience Department of Hepatobiliary Surgery, Fuyang People’s Hospital , Fuyang , China Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital Shanghai JiaoTong University School of Medicine Shanghai China *Internal Medicine and Key Laboratory of Rare Earth Optoelectronic Materials and Devices of Zhejiang Province, Institute of Optoelectronic Materials and Devices, China Jiliang University, Hangzhou 310018, P. R. China Hunan Engineering Research Center of Skin Health and Disease 87 Xiangya Road Changsha Hunan 410008 China; Hunan Key Laboratory of Skin Cancer and Psoriasis 87 Xiangya Road Changsha Hunan 410008 China; Department of Dermatology, Xiangya Hospital Central South University 87 Xiangya Road Changsha Hunan 410008 China Beijing National Laboratory for Molecular Sciences Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education Synthetic and Functional Biomolecules Center College of Chemistry and Molecular Engineering Peking University Beijing 100871 China Fudan University Shanghai Cancer Center, Institutes of Biomedical Sciences, State Key Laboratory of Genetic Engineering and Shanghai Key Laboratory of Medical Epigenetics, Shanghai Medical College of Fudan University, Shanghai 200032, China. College of Life Sciences, Key Laboratory of Biodiversity and Biotechnology of Jiangsu Province, Nanjing Normal University, Nanjing, Jiangsu, China; Department of Metabolic Biology John Innes Centre Norwich Research Park Norwich NR4 7UH UK School of Chinese Medicine, Faculty of Medicine The Chinese University of Hong Kong Hong Kong SAR China Beijing National Research Center for Molecular Sciences, Key Laboratory of Molecular Nanostructure and Nanotechnology, Institute of Chemistry, Chinese Academy of Science, Beijing 100190, China College of Life Science, Anhui provincial Key Lab of the Conservation and Exploitation of Biological Resources, Anhui Normal University, Wuhu, People's Republic of China Affiliated Hospital of Changchun University of Chinese Medicine Changchun Jilin China Department of Neurology and Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215004, China; Sleep Center, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215004, China Department of Microbiology and Infectious Diseases Center, School of Basic Medical Sciences, Peking University Health Science Center, Beijing100191, China. The National Center for Drug Screening and CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CAS), Shanghai 201203, China; University of Chinese Academy of Sciences, Beijing 100049, China CAS Key Laboratory of Receptor Research, and Synthetic Organic & Medicinal Chemistry Laboratory (SOMCL), Shanghai Institute of Materia Medica (SIMM), Chinese Academy of Sciences, Shanghai 201203, China; ShanghaiTech University, Shanghai 20120, China State Key Laboratory of Drug Research and Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang, Jiangsu 212013, China First College of Clinical Medicine, Shandong University of Traditional Chinese Medicine College of Life Science, Inner Mongolia University, Key Laboratory of Mammal Reproductive Biology and Biotechnology, Ministry of Education, Hohhot 010021, China. College of Materials Science and Engineering, Zhejiang University of Technology, Hangzhou 310014, China Key Laboratory of Synthetic and Self-assembly Chemistry for Organic Functional Materials Shanghai Institute of Organic Chemistry Chinese Academy of Sciences No. 345 Lingling Rd. Shanghai 200032 P. R. China From the Cardiovascular Research Institute (Q.C., J.-B.L., K.M.H., H.Z., A.R.K.K., J.L., F.L., A.M.G., X.W.), South Dakota Health Research Foundation, University of South Dakota School of Medicine and Sioux Valley Hospitals and Health System, Sioux Falls; National Eye Institute (E.F.W.), National Institutes of Health, Bethesda, Md; Department of Pathophysiology (J.-B. L), Guangzhou Medical College, Guangzhou, Guangdong, China; and Department of Laboratory Medicine (F. L.) and Division of Basic... State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Bioactive Natural Product Research School of Traditional Chinese Pharmacy China Pharmaceutical University Nanjing China Department of Ophthalmology, College of Medicine, University of Florida, Gainesville, Florida. State Key Laboratory of Infectious Disease Diagnosis and Treatment, First Affiliated Hospital, Zhejiang University College of Medicine Zhejiang PR China State Key Laboratory of Membrane Biology and Beijing Key Laboratory of Cardiometabolic Molecular Medicine; Institute of Molecular Medicine and Peking-Tsinghua Center for Life Sciences and PKU-IDG/McGovern Institute for Brain Research; Peking University; Beijing 100871; China Center for Joining and Electronic Packaging, State Key Laboratory of Material Processing and Die & Mould Technology, School of Materials Science and Engineering, Huazhong University of Science and Technology, Wuhan 430074, China Key Laboratory of Cluster Science Ministry of Education, Beijing Key Laboratory of Photoelectronic/Electrophotonic Conversion Materials, School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing 102401, P.R. China College of Geography and Environment, Shandong Normal University, Jinan, Shandong, People’s Republic of China Huaxi MR Research Center, Department of Radiology, Functional and Molecular Imaging Key Laboratory of Sichuan Province, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu 610041, China School of Public Health, Wannan Medical College, Wuhu, Anhui, China (mainland) Department of Emergency, Qingdao Hospital of Traditional Chinese Medicine, Qingdao Hiser Hospital, Qingdao 266033, China Research Center of Advanced Materials Science and Technology and MOE Key Laboratory of Interface Science and Engineering in Advanced Materials, Taiyuan University of Technology, Taiyuan 030024, People’s Republic of China Key Laboratory for Rare Disease of Shandong Province, Department of Pharmacology, Institute of Materia Medica, Shandong Academy of Medical Sciences, Jinan, China Health Policy and Management, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania Department of Laboratory Medicine TaiHe Hospital Hubei University of Medicine Shiyan Hubei 442000 China State Key Laboratory of Crop Genetics and Germplasm Enhancement Nanjing Agricultural University Nanjing China Key Laboratory of Electronics Engineering, College of Heilongjiang Province Heilongjiang University Harbin China PLA Strategy Support Force Information Engineering University, Zhengzhou, Henan Province 450001, China State Key Laboratory of Low-Dimensional Quantum Physics, Department of Physics & Tsinghua-Foxconn Nanotechnology Research Center, Tsinghua University, Beijing 100084, China Key Laboratory for Organic Electronics and Information Displays & Institute of Advanced Materials (IAM); Jiangsu National Synergistic Innovation Center for Advanced Materials (SICAM); Nanjing University of Posts & Telecommunications; Nanjing 210023; China Department of Neurology; The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Neurology; Chongqing 400016 China Department of Chemistry Brandeis University 415 South Street Waltham MA 02454 USA Advion BioSystems, Inc., 30 Brown Road, Ithaca, New York 14850 Zhejiang Provincial Engineering Technology Research Center of Marine Biomedical Products, School of Food and Pharmacy, Zhejiang Ocean University, Zhoushan 316000, China College of Animal Science and Technology, Northwest A&F University, Yangling, 712100, P. R. China State Key Laboratory for Diagnosis and Treatment of Infectious Disease, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China; Department of Infectious Disease, Second Affiliated Hospital of Wenzhou Medical College, Wenzhou 325027, China Guangdong Provincial Key Laboratory of Optical Fiber Sensing and Communication, Institute of Photonics Technology, Jinan University, Guangzhou 510632, China Department of Geriatrics, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, China (mainland) Department of Neurology The Fourth Affiliated Hospital of China Medical University Shenyang Liaoning China Institute of Molecular and Crystal Engineering, School of Chemistry and Chemical Engineering, Henan University, Kaifeng 475004, People’s Republic of China Center for Genomic and Personalized Medicine, Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, China; Research Center for Guangxi Reproductive Medicine, First Affiliated Hospital of Guangxi Medical University, Guangxi Zhuang Autonomous Region, China CAS Center for Excellence in Nanoscience CAS Key Laboratory of Nanosystem and Hierarchical Fabrication National Center for Nanoscience and Technology University of Chinese Academy of Sciences Beijing 100190 China Department of Chemistry, Institute for Advanced Study, Institute of Molecular Functional Materials, Division of Biomedical Engineering, The Hong Kong University of Science and Technology (HKUST), Clear Water Bay, Kowloon, Hong Kong (S.A.R. China). The First Clinical Medical College of Harbin Medical University, Heilongjiang 150001, China. hydyylj@163.com School of Mining, Inner Mongolia University of Technology, Hohhot 010051, China; Engineering Research Center of Inner Mongolia Autonomous Region for Ecological Building Materials and Assembly Structure, Hohhot 010051, China State Key Laboratory of Heavy Oil Processing and Department of Biological and Energy Chemical Engineering, China University of Petroleum (East China), 66 Changjiang West Road, Qingdao 266580, China CAS and Shandong Province Key Laboratory of Experimental Marine Biology, Center of Deep-Sea Research, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China; College of Marine Science, University of Chinese Academy of Sciences, Beijing 100049, China; Laboratory for Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, Qingdao 266071, China; Key Laboratory of Breeding Biotechnology and Sustainable Aquaculture, Chinese Academy of Sciences, Qingdao 266071, China Department of Hepatobiliary Surgery First Affiliated Hospital, Xi'an Jiaotong University Xi'an China State Key Laboratory of Chemo/Biosensing and Chemometrics, Advanced Catalytic Engineering Research Center of the Ministry of Education, College of Chemistry and Chemical Engineering, Hunan University, Changsha, Hunan 410082, P. R. China Spine Surgery, Ningbo Medical Centre Li Huili Hospital, Ningbo 315040, China. Institute for Infectious Disease and Endemic Disease Control, Beijing Center for Disease Control and Prevention, Beijing 100013, China. Bonan Operating Company of CNOOC Led, Tianjin, 300452, China Ocean University of China, Qingdao 266003, PR China State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China Department of Chemistry and Institutes of Biomedical Sciences, Fudan University, Shanghai 200433, China Department of Pathology, Chinese PLA General Hospital, Beijing 100853, China. Department of Hematology,Hebei General Hospital, Shijiazhuang 050051, Hebei Province, China,E-mail: doclijie@163.com. Key Laboratory of Cluster Science, Ministry of Education, Beijing Key Laboratory of Photoelectroic/Electrophotonic Conversion Materials, School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing 100081 P.R. China Department of Chemistry and Biochemistry, University of South Carolina, Columbia, South Carolina 29208, United States 1Division of Cancer Biology, Department of Radiation Oncology, School of Medicine, Washington University in St. Louis, St. Louis, Missouri. From the Division of Inflammation Biology, La Jolla Institute for Allergy and Immunology, CA. Department of Dermatology, Central South University, XiangYa Hospital, Changsha, Hunan, China Departments of Intensive Care Unit Zhangjiagang TCM Hospital Affiliated to Nanjing University of Chinese Medicine, No.77 Changan Southern Road Jiangsu Province China Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences/Peking Union Medical College, Beijing, 100730, China Yellow Sea Fisheries Research Institute Chinese Academy of Fishery Sciences Qingdao China; Laboratory for Marine Fisheries Science and Food Production Processes Pilot National Laboratory for Marine Science and Technology (Qingdao) Qingdao China MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science South China Normal University Guangzhou 510631 China; College of Biophotonics South China Normal University Guangzhou 510631 China Department of Chemistry, University of Guelph, Guelph, Ontario N1G 2W1, Canada State Key Laboratory of Materials-Oriented Chemical Engineering and College of Chemical Engineering, Nanjing Tech University, No. 30, Puzhu Road(s), Nanjing 211816, PR China College of Public Health, Harbin Medical University, Harbin 150086, China. Clinical Research Center, Dazhou Central Hospital, Dazhou, China. Institute of Psychological Sciences Hangzhou Normal University Hangzhou P.R. China Division of Breast Surgery, Department of General Surgery, General Hospital of Chinese People's Liberation Army (301 Hospital), Beijing Department of General Surgery, Second Affiliated Hospital of Medical School, Xi'an Jiaotong University, Xi'an, 710004. College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, PR China Department of Spinal Surgery, The Third Hospital of Hebei Medical University, Shijiazhuang, Hebei 050051, P.R. China Department of Oncology, Mianyang Central Hospital, Mianyang 621000, Sichuan Province, China CAS Key Laboratory of Marine Bio-resources Sustainable Utilization, RNAM Center for Marine Microbiology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, PR China; The Key Laboratory for Microbial Resources of the Ministry of Education, PR China, and Laboratory for Conservation and Utilization of Bio-Resources, Yunnan Institute of Microbiology, Yunnan University, Kunming 650091, PR China CAS Key Laboratory of Urban Pollutant Conversion, Department of Chemistry, University of Science and Technology of China, Hefei, 230026, China Hefei National Laboratory for Physical Sciences at the Microscale, Department of Biophysics and Neurobiology, University of Science and Technology of China, Hefei, Anhui 230027, People’s Republic of China; Department of Gynecology and Obstetrics, Tianjin Medical University General Hospital, Tianjin 300052, P.R. China Institute for Advanced Ceramics, State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, Harbin 150001, China College of Life Science Sichuan University Chengdu China; National Engineering Laboratory for Oral Regenerative Medicine Sichuan University Chengdu China; State Key Laboratory of Oral Diseases Sichuan University Chengdu China Zhejiang Provincial Key Laboratory of Agricultural Resources and Environment, Institute of Soil and Water Resources and Environmental Science, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China College of Chemistry and Materials Science, Hengyang Normal University, Hengyang 421008, Hunan, People's Republic of China The First People’s Hospital of Baiyin, China Department of Gynecology, The Eastern Hospital of the First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510700, China College of Veterinary Medicine, Northwest A&F University, Xianyang 712100, China; Key Laboratory of Animal Biotechnology, Ministry of Agriculture and Rural Affairs, Northwest A&F University, Xianyang 712100, China Department of Integrated Operations, Chinese Association for STD and AIDS Prevention and Control, Beijing, China Department of Obstetrics and Gynecology, Center for Reproductive Medicine Anhui Provincial Hospital Affiliated to Anhui Medical University Hefei Anhui China Urology Institute of People's Liberation Army, Southwest Hospital, Third Military Medical University, Chongqing, People's Republic of China School of Acupuncture and Massage, and Shaanxi University of Chinese Medicine, Xian yang, People's Republic of China. Scientific Research Center, Fourth Hospital Hebei Medical University Shijiazhuang China Research Institute for Electronic Science, Hokkaido University, Sapporo 001-0021, Japan Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences Chongqing China; Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education Chongqing China Department of Gastroenterology, Affiliated Hospital of Jiangsu University, Jiangsu University, Zhenjiang, China Breast Disease Center, The First Affiliated Hospital, Sun Yat-Sen University, Guangdong, China Department of Respiratory Medicine, Dong Zhi Men Hospital, Beijing University of Chinese Medicine , Beijing, China Center for Carbon-based Electronics and Key Laboratory for the Physics and Chemistry of Nanodevices, School of Electronics, Peking University , Beijing 100871 , China Key Laboratory of Special Functional and Smart Polymer Materials of Ministry of Industry and Information Technology; School of Chemistry and Chemical Engineering; Northwestern Polytechnical University; Xi'an; China College of Chemistry; Chemical Engineering and Materials Science; Soochow University; Suzhou 215123; PR China State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing, PR China; Colleges of Life Sciences, University of Chinese Academy of Sciences, Beijing, China Department of Anatomy and Histology School of Basic Medical Sciences Tianjin Medical University Tianjin China Key Laboratory of Interface Science and Engineering in Advanced Materials Taiyuan University of Technology Taiyuan 030024 P. R. China Department of Infectious Diseases, Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School, Nanjing, Jiangsu, China; Institute of Viruses and Infectious Diseases, Nanjing University, Nanjing, Jiangsu, China Institute of International Rivers and Eco-security, Yunnan University, Kunming, Yunnan, China; Yunnna Key Laboratory of International Rivers and Transboundary Eco-security, Yunnan University, Kunming, Yunnan, China Division of Hepatobiliary and Pancreatic Surgery; Department of Surgery, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases; the First Affiliated Hospital; Zhejiang University School of Medicine; Hangzhou China; Key Laboratory of Combined Multi-organ Transplantation; Key Laboratory of Organ Transplantation; Ministry of Public Health; Hangzhou China; Key Laboratory of Organ Transplantation; Hangzhou Zhejiang China Department of General Surgery, Qianfoshan Hospital, Shandong University, Jinan, China Department of Geriatrics National Key Clinic Specialty Guangzhou First People’s Hospital Guangzhou Medical University Guangzhou China CV Technologies Inc., Edmonton Research Park, 9411-20th Avenue, Edmonton, Alberta, Canada T6N 1E5 Department of Neurosurgery, University of California, San Diego, La Jolla, California. Institute for Advanced Study, Shenzhen University 1 , Shenzhen 518060, China Department of Urology, The First Affiliated Hospital, Chongqing Medical University, Chongqing, 400016, China Shandong New Time Pharmaceutical Co., Ltd. Lunan Pharmaceutical Group Co., Ltd. Linyi China; Center for New Drug Safety Evaluation of Lunan Pharmaceutical Lunan Pharmaceutical Group Co., Ltd. Linyi China; State Key Laboratory of Generic Manufacture Technology of Chinese Traditional Medicine Lunan Pharmaceutical Group Co., Ltd. Linyi China Department of Anesthesia and Intensive Care, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China Radiopharmaceuticals Center Shanghai Institute of Applied Physics, Chinese Academy of Sciences Shanghai China; Shanghai Institute of Applied Physics University of Chinese Academy of Sciences Beijing China From the Division of Basic Biomedical Sciences (H.S., J. Li, A.R.K., X.W.) and Cardiovascular Research Institute (H.S., J. Li, J. Liu, A.R.K., X.W.), Sanford School of Medicine of the University of South Dakota, Vermillion; Department of Molecular, Cellular and Developmental Biology (S.M., N.W.), Yale University, New Haven, Conn; and Department of Pathophysiology (J. Liu), Guangzhou Medical College, Guangzhou, Guangdong, China. Present address for S.M.: Department of Genetics and Complex Diseases,... Glycochemistry and Glycobiology Laboratory, Shanghai Institute of Materia Medica, Chinese Academy of Science, Shanghai, China Center for Translational Medicine, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, China; Key Laboratory for Tumor Precision Medicine of Shaanxi Province, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, China; Department of Gynecology and Obstetrics, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, China Centre for AIE Research, College of Material Science and Engineering, Shenzhen University, Shenzhen 518061, P. R. China; Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Optoelectronic Engineering, Shenzhen University, Shenzhen 518061, P. R. China Department of Epidemiology and Health Statistics, School of Public Health Anhui Medical University Hefei China The Guangxi Zhuang Autonomous Region Family Planning Research Center; Nanning China Institute of Photonics and Photon‐Technology, Northwest University Xi'an Shaanxi China; School of Physics and Electronic Engineering Xianyang Normal University Xianyang Shaanxi China Department of Physics and Astronomy, University of California, Irvine, CA 92697-4575, USA.; State Key Laboratory of Surface Physics and Key Laboratory for Computational Physical Sciences (MOE) and Department of Physics, Fudan University, Shanghai, 200433, China. Key Laboratory of Marine Bio-resources Sustainable Utilization, Chinese Academy of Science (LMB-CAS), Guangdong Key Laboratory of Marine Materia Medica (LMMM-GD), South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China Department of Lymphadenopathy Beijing National Laboratory for Molecular Sciences (BNLMS), College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China Department of Oncology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China (mainland) College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, P. R. China School of Metallurgy and Environment Hunan Provincial Key Laboratory of Nonferrous Value‐Added Metallurgy Engineering Research Center of the Ministry of Education for Advanced Battery Materials Central South University Changsha 410083 PR China Hunan Key Laboratory of Applied Environmental Photocatalysis, Changsha University, Kaifu District, Changsha 410022, Hunan Province, P. R. China Key Laboratory of High Performance Polymer Materials and Technology, of Ministry of Education School of Chemistry and Chemical Engineering Nanjing University Nanjing 210023 P. R. China; Key Lab of Mesoscopic Chemistry of MOE and Jiangsu Key Laboratory, of Advanced Organic Materials School of Chemistry and Chemical, Engineering Nanjing University Nanjing 210023 P. R. China Wenzhou Medical College, Institute of Ocular Pharmacology, School of Ophthalmology and Optometry, Wenzhou, China. College of Materials Science and Engineering, Taiyuan University of Technology, Taiyuan, 030024, P. R. China Division of Basic Biomedical Sciences, Protein Quality Control and Degradation Research Center, Sanford School of Medicine, University of South Dakota, Vermillion, South Dakota; and School of Chemistry and Chemical Engineering Central South University Changsha Hunan 410083 China; Key Laboratory of Hunan Province for Metallurgy and Material Processing of Rare Metals Changsha Hunan 410083 China School of Environmental and Municipal Engineering, Lanzhou Jiaotong University, Lanzhou, Gansu, China Joint Disease & Sport Medicine Center, Department of Orthopedic Surgery Xinqiao Hospital, Army Medical University Chongqing China School of Physics and Electronics, Hunan University Department of Internal Medicine, Division of Gastroenterology-Hepatology, University of Iowa College of Medicine, Iowa City, Iowa 52242; and the Department of Clinical Laboratory, Yantai Yuhuangding Hospital of Qingdao University Medical College, Yantai, China. Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China College of Food Science and Engineering; Shandong Agricultural University; Taian 271018 China Center for Molecular Medicine, National Heart, Lung, and Blood Institute National Institutes of Health Bethesda MD USA Department of Internal Medicine, Jiangxi Provincial Chest Hospital, Nanchang, China. School of Chinese Materia Medica, Beijing University of Chinese Medicine Beijing 102488, China. Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing - PR China Department of Pharmacology, Shanxi Medical University, Taiyuan, Shanxi Province, People's Republic of China From the Departments of Pediatrics, Immunology, Medicine, Pathology, and Surgery, and the Human Vaccine Institute, Duke University Medical Center, Durham, NC. Department of Hematology , Nanfang Hospital, Southern Medical University , Guangzhou 510515 , China Advanced Water Management Centre, The University of Queensland , St. Lucia, Brisbane, QLD 4072, Australia Mudanjiang Medical University, Tongxiang Street No. 3, Mudanjiang, Heilongjiang 157011, PR China Department of Pathology,the First Affiliated Hospital of Xi'an Jiaotong University,Xi'an 710061,China. Center for Membrane Technology, College of Environmental and Energy Engineering, Beijing University of Technology, Beijing 100124, P. R. China Zhejiang Provincial Key Laboratory of Biometrology and Inspection and Quarantine, College of Life Sciences, China Jiliang University, Hangzhou 310018, China Department of Pathology, Chinese People’s Liberation Army General Hospital, Beijing, China (mainland) Cancer Center and Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, Macau SAR 999078, China; MoE Frontiers Science Center for Precision Oncology, University of Macau, Macau SAR 999078, China Food College Shihezi University Shihezi China Department of Spine Surgery, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, Jiangsu, China (mainland) College of Animal Science and Technology Shihezi University Shihezi China Department of Oral and Maxillofacial Surgery The Sixth Affiliated Hospital of Sun Yat‐Sen University Guangzhou China Institute of Physical Chemistry & MEET Battery Research Centre, University of Muenster, Corrensstrasse 28/30 & 46, 48149 Muenster, Germany Division of Gastroenterology-Hepatology, Department of Internal Medicine, University of Iowa, Iowa City, IA 52242 Interdisciplinary Laboratory for Nanoscale Science and Technology, National Institute for Materials Science, 1-2-1 Sengen, Tsukuba, Ibaraki 305-0047, Japan Department of Hematology Hebei General Hospital Shijiazhuang China National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, P.R. China; College of Life Science, Sichuan University, Chengdu, P.R. China Greenwich Biosciences 5750 Fleet St Ste 200 Carlsbad CA USA Department of Biochemistry and Molecular Biology, Beijing Institute of Basic Medical Sciences, Beijing, China. State Key Laboratory for Molecular Virology and Genetic Engineering, National Institute for Viral Disease Control and Prevention, China CDC, Beijing, China Department of Emergency, Maternal and Child Health Hospital of Hubei Province, Tongji Medical College, Huazhong University of Science and Technology, Hubei Wuhan, P.R. China Zigong Third People’s Hospital, Sichuan 643000, China State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing 210023, China. Department of Gastroenterology, First Hospital of Yangtze University Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA Interventional Drug Delivery Systems & Strategies(ID2S2), Jupiter, FL, USA Department of Urology Renmin Hospital of Wuhan University Wuhan China Zhejiang Provincial Engineering Technology Research Center of Marine Biomedical Products, School of Food and Pharmacy, Zhejiang Ocean University, Zhoushan 316022, China Innovative Genomics Institute, University of California, Berkeley, CA 94720.; Department of Bioengineering, University of California, Berkeley, CA 94720. Department of Hepatobiliary and Pancreatic Surgery,The First Affiliated Hospital of Zhengzhou University,Zhengzhou,China; Henan Key Laboratory of Digestive Organ Transplantation,Zhengzhou,China; Open and Key Laboratory of Hepatobiliary & Pancreatic Surgery and Digestive Organ Transplantation at Henan Universities,Zhengzhou,China The Department of Dermatology, Xiangya Hospital, Central South University, Changsha 410000, Hunan, China; National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology, Xiangya Hospital, Changsha 410000, Hunan, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha 410000, Hunan, China; Hunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Changsha 410000, Hunan, China; Hunan Engineering Research Center of Skin Health and Disease, Xiangya Hospital, Changsha 410000, Hunan, China State Key Laboratory of Fine Chemicals Dalian University of Technology 2 Linggong Road Dalian 116024 China Department of Nephrology Liaocheng People’s Hospital Liaocheng China Department of Neonatology, Maternity and Child Health Care of Zaozhuang Zaozhuang China Department of Computer Science, Tongji University, Shanghai, 200000, China; Key Laboratory of Carcinogenesis and Translational Research, Peking University Cancer Hospital and Institute, Beijing, China. Department of Gastroenterology, Xiangshan Hospital Affiliated to Wenzhou Medical University , 291 Donggu Road, Dandong Street, Xiangshan County , Ningbo , 315700 , People’s Republic of China Department of Neurosurgery, Jinling Hospital, Medical School of Nanjing University Nanjing, Jiangsu, China. Austin Research Institute, Austin Hospital, Heidelberg, Victoria, Australia Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, China Xiangya School of Nursing, Central South University, Changsha 410013. 1520993822@qq.com. State Key Laboratory of Biotherapy and Cancer Center West China Hospital Sichuan University Chengdu 610041 P. R. China Guangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation, College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China; National Risk Assessment Laboratory for Antimicrobial Resistance of Animal Original Bacteria, South China Agricultural University, Guangzhou 510642, China Center for General Practice Medicine, Department of Infectious Disease, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital, Hangzhou Medical College), Zhejiang, Hangzhou 310014, China School of Chemistry and Chemical Engineering, Central South University, Changsha 410083, China Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research, Lishui Hospital, School of Medicine, Zhejiang University, Lishui 323000, China; Department of Radiology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310058, China Third ward of Radiotherapy, Shaanxi Provincial Cancer Hospital, Xi’an, PR China Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China Department of Infectious Diseases, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing, People’s Republic of China School of Environmental and Municipal Engineering, Lanzhou Jiaotong University, Lanzhou 730000, China Beijing Key Laboratory of Photoelectronic/Electrophotonic Conversion Materials, Key Laboratory of Cluster Science, Ministry of Education, School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing 100081, People’s Republic of China CapitalBio Genomics Co., Ltd., Dongguan 532808, China Department of Molecular Microbiology & Immunology, Oregon Health & Science University, Portland, Oregon 97239, United States State Key Laboratory of Medical Genetics and School of Life SciencesCentral South UniversityChangshaHunanPeople's Republic of China; Program of Skeletal Disease and Tumor MetastasisCenter for Cancer and Cell BiologyVan Andel Research InstituteGrand RapidsMIUSA Laboratory of Reproductive Medicine and The Research Center for Bone and Stem Cells, Department of Anatomy, Histology and Embryology, Nanjing Medical University Nanjing 210029, China. Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China. Department of Breast Surgery, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China. Affiliations of authors: Oncology Department, Xiyuan Hospital of China Academy of Chinese Medical Sciences, Beijing, China (YX, LS, XJ, JW); Integrative Medicine Service, Memorial Sloan Kettering Cancer Center, New York, NY (JM, LS); Internal Oncology Department, Cancer Hospital of Chinese Academy of Medical Sciences, Beijing, China (LY, JW); Gastroenterology Department, Peking University of Cancer Hospital and Beijing Department of Obstetrics and Gynecology The Affiliated Drum and Tower Hospital of Medical School of Nanjing University Nanjing Jiangsu China Department of Cardiology Tongji Hospital, School of Medicine, Tongji University Shanghai China School of Optical and Electronic Information; Huazhong University of Science and Technology; Wuhan 430074; P. R. China; Key Lab of Functional Materials for Electronic Information (B) CAS Center for Excellence in Nanoscience; CAS Key Laboratory of Nanosystem and Hierarchical Fabrication; National Center for Nanoscience and Technology; Beijing 100190; China Department of Chemistry, Stanford University, Stanford, California 94305 Department of Cardiopulmonary Sciences, Division of Respiratory Care, Rush University Medical Center, Chicago, IL. School of Municipal and Environmental Engineering, Harbin Institute of Technology, Harbin 150090, China. hitlijie@163.com Department of Cardiology The First People's Hospital of ZunYi Zunyi Guizhou China Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing, 210009, Jiangsu, China; Jiangsu Provincial Key Laboratory of Critical Care Medicine, School of Public Health, Southeast University, Nanjing, 210009, China Department of Cardiopulmonary Sciences, Division of Respiratory Care, Rush University, Chicago, Illinois, USA Department of Medical Oncology, Beijing Chest Hospital Capital Medical University Beijing Tuberculosis and Thoracic Tumor Research Institute Beijing China Guangzhou First People’s Hospital, School of Biomedical Sciences and Engineering, South China University of Technology, Guangzhou International Campus, Guangzhou 511442, People’s Republic of China; National Engineering Research Center for Tissue Restoration and Reconstruction, and Key Laboratory of Biomedical Engineering of Guangdong Province, South China University of Technology, Guangzhou, Guangdong 510006, People’s Republic of China Department of Orthopaedics Lihuili Hospital Ningbo Medical Center Ningbo 315040 Zhejiang China. Department of Orthopedics, First Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China School of Materials Science and Engineering, University of Jinan; Jinan 250022; P. R. China Department of Pathology, The First Medical Center of Chinese PLA General Hospital, Beijing, China International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Discovery of Chinese Ministry of Education (MOE), School of Pharmacy, Jinan University, #855 Xingye Avenue, Guangzhou 510632, China Department of Orthopaedics, The Second Affiliated Hospital, School of Medicine, Xi’an Jiaotong University, Xi’an, China Beijing Advanced Innovation Center for Materials Genome Engineering Institute for Advanced Materials and Technology State Key Laboratory for Advanced Metals and Materials University of Science and Technology Beijing Beijing 100083 P. R. China Vascular Biology Center, Medical College of Georgia, Augusta University, Augusta, Georgia Department of Special Requirements Ward, First Affiliated Hospital of Soochow University, Suzhou 215006, Jiangsu Province, China Department of Pathology, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, P. R. China Department of Ophthalmology, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan 610072, P.R. China Yunnan Institute of Microbiology, Yunnan University, Kunming, 650091, PR China State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Zhangjiang Hi-Tech Park, Shanghai 201203, China; Nano Science and Technology Institute, University of Science and Technology of China, 166 Ren Ai Road, Suzhou 215123, China Inspection and Quarantine Technique Center of Fujian Entry-Exit Inspection and Quarantine Bureau, Fuzhou, China Institute of Marine & Environmental Technology, University of Maryland Baltimore County, Baltimore, Maryland, USA Department of Infectious Diseases Shandong Provincial Hospital Affiliated to Shandong University Jinan Shandong China Department of Physiology; Anhui Medical University; Hefei, China College of Chemical and Material Engineering, Quzhou University, Quzhou 324000, P. R. China Ordered Matter Science Research Center, Jiangsu Key Laboratory for Science and Applications of Molecular Ferroelectrics, Southeast University, Nanjing 211189, People’s Republic of China Guang'anmen Hospital,China Academy of Chinese Medical Sciences Beijing 100053,China. Laboratory of Molecular Neural Biology; School of Life Sciences; Shanghai University; Shanghai 200444; China College of Animal Science and Technology, Gansu Agricultural University, Lanzhou 730070, China Department of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China Institute of Population and Development Studies, School of Public Policy and Administration, Xian Jiaotong University, Xi'an, Shaanxi Province 710049, China; School of life sciences; Jilin University; Changchun; People's Republic of China School of Life Sciences, Beijing Advanced Innovation Center for Structural Biology, and Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing, China; Department of Cardiology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510800, China; Key Laboratory on Assisted Circulation, Ministry of Health, Guangzhou 510800, China State Key Laboratory of Reproductive Medicine and Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China University of Electronic Science and Technology of China School of Medicine Chengdu 610054 China Horticultural Research Institute Shanxi Academy of Agricultural Science Taiyuan China State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Sciences, and Collaborative Innovation Center of Chemical Science and Engineering, and National Institute of Functional Materials, Nankai University, Tianjin 300071, People’s Republic of China Oncology Department, Beijing Chest Hospital of Capital Medical University, Beijing, China Department of Neurology and Suzhou Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215004, China From the State Key Laboratory of Respiratory Disease and Department of Pathophysiology, Guangzhou Medical University, Guangzhou, Guangdong, China (H.S., J.Liu, X.W.); Division of Basic Biomedical Sciences, Sanford School of Medicine of the University of South Dakota, Vermillion (H.S., J.Li, H.Z., J.Liu, X.W.); Vascular Biology Center (H.S., J.Li, W.M.) and Department of Pharmacology and Toxicology (H.S.), Medical College of Georgia, Georgia Regents University, Augusta; and Department of Molecular,... Department of Infectious Disease, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, People’s Republic of China Department of Clinical Laboratory, Xingyi People's Hospital, China. Jiangsu Key Laboratory for Science and Applications of Molecular Ferroelectrics, Southeast University , Nanjing 211189 , China College of Animal Science and Technology, Shihezi University, Shihezi, Xinjiang 832003, P.R. China Department of Nephrology, Zhuzhou Hospital Affiliated to Xiangya Medical College, Central South University, Zhuzhou, Hunan, China. College of Artificial Intelligence, Faculty of Materials and Energy, Southwest University, Chongqing 400715, China Department of Nursing, The Second Affiliated Hospital of Nantong University Nantong 226006, Jiangsu, China. College of Chemistry, Chemical Engineering and Materials Science, Engineering Research Center of Pesticide and Medicine Intermediate Clean Production, Ministry of Education, Shandong Normal University, Jinan 250014, People's Republic of China, and School of Chemistry, Monash University, Victoria 3800, Australia Beijing Cancer Hospital Peking University Cancer Hospital & Institute Beijing China Department of Chemistry and Biochemistry and Department of Mechanical Engineering and Bioengineering Program, University of Maryland, College Park, Maryland 20742, Calibrant Biosystems, 910 Clopper Road, Suite 220N, Gaithersburg, Maryland 20878, and Molecular Pathogenesis Unit, Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland 20892 State Key Laboratory of Environmental-Friendly Energy Materials, School of Materials Science and Engineering, Southwest University of Science and Technology, Mianyang 621010, China Department of Laboratory Medicine, Peking University Shenzhen Hospital, Shenzhen, China Department of Surgery and The Alvin J. Siteman Cancer Center, Washington University School of Medicine, Campus Box 8109, 660 South Euclid Avenue, St. Louis, MO 63110; and Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, MI 48109 Department of Gastrointestinal Oncology Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing) Peking University Cancer Hospital & Institute Beijing 100142 P. R. China Shandong University of Traditional Chinese Medicine, Jinan 250355, China Department of Pathology, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, Fujian 350004, P.R. China College of Chemical Engineering; Nanjing Forestry University; Nanjing 210037; China Key Laboratory of Drug Quality Control and Pharmacovigilance (Ministry of Education), China Pharmaceutical University, Nanjing 210009, China Ophthalmology, Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital, Chengdu, China CAS Key Laboratory of Coastal Environmental Processes and Ecological Remediation, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China; Shandong Key Laboratory of Coastal Environmental Processes, Yantai 264003, China; University of Chinese Academy of Sciences, Beijing 100049, China College of First Clinical Medicine, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China (mainland) Department of Urology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China. School of Mechanical Engineering Chengdu Industry and Trade College Chengdu 611731 China Shanghai Institute for Advanced Immunochemical Studies ShanghaiTech University 201210 Shanghai P. R. China Hefei National Laboratory for Physical Sciences at the Microscale CAS Key Laboratory of Materials for Energy Conversion Department of Materials Science and Engineering University of Science and Technology of China Hefei Anhui 230026 China Department of Vitreoretinopathy, Shanxi Eye Hospital, Taiyuan, Shanxi, China Center for Joining and Electronic Packaging State Key Laboratory of Material Processing and Die & Mould Technology School of Materials Science and Engineering Huazhong University of Science and Technology Wuhan 430074 China Stanford University Department of Chemistry, , Stanford, California 94305 Sichuan Agricultural University, Yaan, China From the Division of Basic Biomedical Sciences, University of South Dakota, Sanford School of Medicine, Vermillion (B.P., J. Li, N.P., Z.T., P.W., M.T.L., H.S., X.W.); Vascular Biology Center and Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta University (J. Li, J.Z., W.W., H.S.) Department of Pathology, Japan-China Friendship Hospital, Beijing, China (mainland) Department of Gastroenterology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430014, P.R. China Key Laboratory of Instrumentation and Science and Dynamic Measurement, Ministry of Education, North University of China 1 , Taiyuan 030051, People’s Republic of China; School of Instrument and Electronics, North University of China 2 , Taiyuan 030051, People’s Republic of China Department of Hematology, 100th hospital of People’s Liberation Army, Suzhou City, Jiangsu Province, China Department of Hepatobiliary Surgery, ZhongShan Hospital of Xiamen University, Xiamen, Fujian 361005, China; Fujian Provincial Key Laboratory of Chronic Liver Disease and Hepatocellular Carcinoma, ZhongShan Hospital of Xiamen University, Xiamen, Fujian 361005, China Department of Genetics and Cell Biology, College of Life Science, Nankai University , Tianjin 300071 , China; State Key Laboratory of Medicinal Chemical Biology, Nankai University , Tianjin, 300350 , China Sichuan Cancer Hospital and Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Radiation Oncology Key Laboratory of Sichuan Province, Chengdu, Sichuan 610041, P.R. China Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100730, China Department of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, PR China Center for Stem Cell Research and Regenerative Medicine, Tulane University School of Medicine, New Orleans, LA, USA. LaCell LLC, New Orleans, LA, USA. Earth and Environmental Sciences, University of Michigan, Ann Arbor, MI 48109; School of Food Engineering, Wuchang Institute of Technology, Wuhan 430065, P. R. China School of Pharmacy, China Medical University, Shenyang, China Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China. Membrane Biology Laboratory New York Blood Center New York New York 10065 International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development, Ministry of Education (MOE) of China, College of Pharmacy, Jinan University, # 855 Xingye Avenue, Guangzhou 510632, China Guangxi Reproductive Medical Research Center First Affiliated Hospital of Guangxi Medical University Nanning China Nanjing University of Posts and Telecommunications State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China. Department of Anatomy and Histology, School of Basic Medical Sciences Tianjin Medical University Tianjin China; Key Laboratory of Hormones and Development (Ministry of Health), Tianjin Key Laboratory of Metabolic Diseases Tianjin Medical University Tianjin China Institute of Condensed Matter and Nanosciences, Université catholique de Louvain, Croix du Sud 1 L7.04.02, Louvain-la-Neuve, Belgium Bioinformatics Core, University of California, Davis, California, USA From the Departments of Ultrasound (Yan Zhang, W.L., J.H.Z., Ying Zhang, H.Y.H., Y.K.L.) and Pathology (J.L.), Division of First Medical Center, Chinese People’s Liberation Army General Hospital, 28 Fuxing Rd, Beijing 100853, China; and Department of Ultrasound, Division of Second Medical Center, Chinese People’s Liberation Army General Hospital, Beijing, China (Y.Y.L.). Department of Radiology, Hangzhou Normal University Affiliated Hospital College of Stomatology, Chongqing Medical University, Chongqing 401147, P.R. China Department of Physics and Astronomy University of California, Irvine Irvine CA 92697 USA Jinan University Key Laboratory of Pesticide & Chemical Biology of Ministry of Education Institute of Environmental Chemistry College of Chemistry Central China Normal University Wuhan 430079 P. R. China; Institute of Nanoscience and Nanotechnology College of Physical Science and Technology Central China Normal University Wuhan 430079 P. R. China Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States Department of Breast and Thyroid Surgery, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong 510080, China Department of Oncology 1Surgical Neurology Branch, National Institutes of Neurological Disorders and Stroke, NIH, Bethesda, Maryland and State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China; University of Chinese Academy of Sciences, Beijing, China Sugarcane Research Institute, Yunnan Academy of Agricultural Sciences, Yunnan Key Laboratory of Sugarcane Genetic Improvement, Kaiyuan 661699, China Department of Neurology Second Affiliated Hospital of Harbin Medical University Harbin P. R. China Guangzhou Key Laboratory of Environmental Health and Risk Assessment Department of Toxicology School of Public Health Sun Yat‐sen University Guangzhou China; Collaborative Innovation Center for Cancer Medicine Sun Yat‐sen University Cancer Center Guangzhou China Intramural Research Program; National Institute on Drug Abuse; Baltimore; MD; USA Department of Electrical Engineering, The Pennsylvania State University, University Park, Pennsylvania 16802, United States Department of Pathology, Chinese PLA General Hospital, Medical School of Chinese PLA, Beijing, China (mainland) the Second Department of Oncology, Cangzhou Central Hospital, Cangzhou, Hebei Province 061001, China. Email: lijie709925@163.com. 1Department of Immunology, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China; 3Third Affiliated Hospital of Southern Medical University, Guangdong Academy of Orthopaedics, Guangzhou 510000, China. E-mail: 164757254@qq.com. Department of Psychology, Renmin University of China, China Department of Biochemistry, Purdue University, West Lafayette, IN, USA State key Laboratory of Drug Research Shanghai Institute of Materia Medica Chinese Academy of Sciences Shanghai 201203 China; School of Life Science and Technology ShanghaiTech University Shanghai 201210 China; University of Chinese Academy of Sciences 19A Yuqian Road Beijing 100049 China The First Institute of Oceanography *Division of Experimental Immunology, Institute for Genome Research, University of Tokushima, Tokushima, Japan; and Department of Infectious Diseases, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China 20131004@hznu.edu.cn lijier@sina.com. Key Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM); Nanjing Tech University (NanjingTech); Nanjing 211816; China Thoracic Cancer Center Department of Respiratory Medicine Xijing Hospital Fourth Military Medical University Xi'an Shaanxi China Department of Cellular and Integrative Physiology, Center for Biomedical Neuroscience, School of Medicine University of Texas Health Science Center San Antonio Texas School of Life Science, Nanchang University, Nanchang 330031, China 1Surgical Neurology Branch, National Institutes of Neurological Disorders and Stroke, NIH, Bethesda, Maryland; Laboratory of Membrane Biology, Medical Experiment Center, Guangdong Second Provincial General Hospital , Guangdong , PR China Key Laboratory for the Physics and Chemistry of Nanodevices, School of Electronics, Peking University, Beijing 100871, China Laboratory of Nuclear Energy Chemistry, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China Department of Dermatology, Xiangya Hospital, Central South University, Changsha 410008, China. State Key Laboratory for Infectious Disease Prevention and Control National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention Beijing 102206 China Department of Heart Disease, Shanxi Hospital of Traditional Chinese Medicine, Taiyuan. Department of Breast Surgery, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100043, P.R. China Hospital for First Affiliated Hospital of Guangzhou University of Chinese Medicine, 16th Jichang Road, Baiyun District, Guangzhou 510405, China Department of Health Psychology, School of Nursing Shandong University Jinan Shandong China Research Center of Materials Science, Beijing Institute of Technology, Beijing 100081, People's Republic of China Department of Oncology, Mian Yang Central Hospital, Sichuan, People’s Republic of China; Department of Oncology, Attached Hospital to North Sichuan Medical College, Sichuan, People’s Republic of China Department of Medical Intensive Care Unit, Maternal and Child Health Hospital of Hubei Province, Tongji Medical College, Huazhong University of Science and Technology , Wuhan, Hubei 430070 , China Department of Infectious Disease Shandong Provincial Hospital Affiliated to Shandong University Jinan China Kunming Branch of Yunnan Tobacco Company, Kunming 650051, PR China Department of Chest Surgery The General Hospital of The People's Liberation Army Beijing China Department of Computer Science and Technology, Harbin Institute of Technology, Harbin, China National Key Laboratory of Green Pesticide, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, State-Local Joint Laboratory for Comprehensive Utilization of Biomass, College of Pharmacy & Center for R&D of Fine Chemicals, Guizhou University, Guiyang, Guizhou 550025, China Department of Infectious Disease,Shandong Provincial Hospital Affiliated to Shandong University,Shandong,China Department of Infectious Disease, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325027, China Key Laboratory of Tropical Forest Ecology, Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences; Kunming 650223 China Department of Hepatobiliary Surgery First Affiliated Hospital, Xi’an Jiaotong University Xi’an China Division of Medicinal Chemistry and Pharmacognosy The Ohio State University Columbus OH USA Oncology Department, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China Gastroenterology 1Division of Experimental Hematology, Cincinnati Children's Hospital Medical Center; Department of Radiation Oncology Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China Chengdu China Computational and Systems Biology Group, Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore. School of Metallurgy and Environment, Central South University, Changsha, Hunan 410083, China; College of Chemistry and Chemical Engineering, Central South University, Changsha, Hunan 410083, China Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China; Henan Liver Transplantation Center, Zhengzhou, Henan Province, 450052, China; Henan Research Center for Organ Transplantation, Zhengzhou, 450052, China; Henan Key Laboratory of Digestive Organ Transplantation, Zhengzhou, 450052, China Department of Infectious Disease Shandong Provincial Hospital affiliated to Shandong First Medical University Jinan Shandong China; Department of Infectious Disease, Cheeloo College of Medicine, Shandong Provincial Hospital Shandong University Jinan Shandong China Department of Microbiology & Infectious Disease Center, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China Department of Oral and Maxillofacial Surgery, The Sixth Affiliated Hospital of Sun Yat‑Sen University, Guangzhou, Guangdong 510655, P.R. China Laboratory of Pharmacology & Toxicology, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China State Key Laboratory of Pollution Control and Resource Reuse Study, College of Environmental Science & Engineering, Tongji University, 1239, Siping Road, Shanghai 200092, China Xidian University Department of Hematology, the Second Hospital of Hebei Medical University, Shijiazhuang, China. Center for Stem Cell Research & Regenerative Medicine Tulane University School of Medicine New Orleans Louisiana; National Engineering Laboratory for Oral Regenerative Medicine, West China School of Stomatology Sichuan University Chengdu China Department of Geriatrics, National Clinical Key Specialty, Guangzhou First People’s Hospital, School of Medicine, South China University of Technology, Guangzhou, 510180, Guangdong, China College of Mechatronics Engineering and Automation, National University of Defense Technology, Changsha, Hunan 410073, China Department of Chemistry; Brandeis University; Waltham; USA Department of Neurology, the People's Hospital of Deyang City School of Nursing Shandong University Jinan P.R. China Center for AIE Research Shenzhen Key Laboratory of Polymer Science and Technology Guangdong Research Center for Interfacial Engineering of Functional Materials College of Materials Science and Engineering Shenzhen University Shenzhen 518060 China Graduate School, Wuhan Sports University, Wuhan, China; and National Key Laboratory of Crop Genetic Improvement and National Center of Plant Gene Research (Wuhan), Huazhong Agricultural University, Wuhan 430070, China Department of Orthopedics, Chongqing Emergency Medical Center, Chongqing, China (mainland) Department of Orthopaedic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China; Key Laboratory of Musculoskeletal System Degeneration and Regeneration Translational Research of Zhejiang Province, Hangzhou, Zhejiang, China; Department of Orthopaedic Surgery, Ningbo Medical Center Li Huili Hospital, Ningbo, Zhejiang, China Shanghai Institute for Advanced Immunochemical Studies ShanghaiTech University Shanghai 201210 P. R. China 4Department of Biochemistry, Purdue University, West Lafayette, Indiana. Department of Hematology, Hebei General Hospital, Shijiazhuang 050051, Hebei Province, China. School of Metallurgy and Environment; Central South University; Changsha 410083; China Department of General Surgery, Shanxi Provincial People's Hospital, Taiyuan 030012, Shanxi, China College of Materials and Chemical Engineering, Pingxiang University, Pingxiang, Jiangxi 337055, P. R. China School of Physics and Mechanical & Electronical Engineering; Hubei University of Education; Wuhan 430205; China Department of Pediatrics, Duke University Medical Center, Durham, NC; Department of Obstetrics and Gynecology, Chinese PLA General Hospital, Beijing 100853, China Department of Special Requirements Ward, First Affiliated Hospital, Soochow University, Suzhou 215006, China. Laser Fusion Research Center Department of Nephrology, Lishui Municipal Central Hospital, Lishui, Zhejiang Province, China Department of Geratology, First Hospital, Jilin University, Changchun, Jilin Province, China Chinese Academy of Sciences Chongqing Academy of Animal Sciences, Rongchang 402460, China Department of Ultrasound, Qilu Hospital of Shandong University, Jinan, Shandong, China (mainland) State Key Laboratory of Radiation Medicine and Protection; School of Radiation Medicine and Protection; Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions; Soochow University; Suzhou 215123 Department of Pulmonary and Critical Care Medicine, The Ninth Hospital of Xi’an Affiliated with Xi’an Jiaotong University, Xi’an, Shaanxi 710054, China Department of Infectious Diseases, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Jiangsu 210008, China Department of Medical Image Center, Yangzhou University Affiliated Northern Jiangsu People’s Hospital, Yangzhou, Jiangsu, China College of Life Sciences, Huaibei Normal University, Huaibei 235000, China Department of Obstetrics and Gynecology, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing 210008, China; Center for Membrane Technology, College of Environmental and Energy Engineering, Beijing University of Technology, 100 Ping Le Yuan, Chaoyang District, Beijing 100124, P.R. China State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China. lijiehust@126.com College of Pharmacy National & Local Joint Engineering Research Center of Targeted and Innovative Therapeutics IATTI Chongqing University of Arts and Sciences 319 Honghe Ave., Yongchuan 402160 Chongqing P. R. China Department of Laboratory Medicine, M.O.E. Key Laboratory of Laboratory Medicine Diagnostics; Chongqing Medical University; Chongqing 400016 P. R. China From the Departments of Pediatrics, Immunology, Medicine, Pathology, and Surgery, and the Human Vaccine Institute, Duke University Medical Center, Durham, NC; Departments of Pediatrics and Surgery, the University of North Carolina, Chapel Hill, NC; and Laboratoire d'Immunologie Pédiatrique, Hospital Necker Enfants Malades, Paris, France State Key Laboratory of Fine Chemicals Frontiers Science Center for Smart Materials Dalian University of Technology 2 Linggong Road 116024 Dalian China; School of Chemistry and Chemical Engineering Key Laboratory of Special Functional and Smart Polymer Materials of Ministry of Industry and Information Technology Northwestern Polytechnical University 710072 Xi'an China Office of Surveillance and Epidemiology, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland. Department of Health Policy and Management, University of Pittsburgh, Pittsburgh, PA Department of Radiology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266001, P.R. China Key Laboratory of Novel Thin Film Solar Cells, Institute of Plasma Physics, Chinese Academy of Sciences, 230031, Hefei, PR China Department of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan, China.; National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology, Changsha, Hunan, China.; Furong Laboratory, Changsha, Hunan, China.; Hunan Key Laboratory of Skin Cancer and Psoriasis, Hunan Engineering Research Center of Skin Health and Disease, Xiangya Hospital, Central South University, Changsha, Hunan, China.; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China. School of Chemical Engineering; Northwest University; Xi'an; China Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200241, China Research Center for Biomimetic Functional Materials and Sensing Devices, Institute of Intelligent Machines, Chinese Academy of Sciences, Hefei 230031, PR China College of First Clinical Medicine Shandong University of Traditional Chinese Medicine Jinan Shandong PR China Joint Laboratory for Research on Active Components and Pharmacological Mechanism of Tibetan Materia Medica of Tibetan Medical Research Center of Tibet, School of Medicine, Xizang Minzu University, Xianyang, China Department of Epidemiology and Health Statistics School of Public Health Anhui Medical University Hefei Anhui China School of Materials Science and Engineering Qilu University of Technology (Shandong Academy of Sciences) Jinan 250353 China College of Chemistry and Chemical Engineering, Southwest Petroleum University, Chengdu, 610500, PR China Department of Biochemistry, University of New Hampshire, Durham, New Hampshire 03824 Department of Hematology, Qilu Hospital, Shandong University, Jinan, China; Key laboratory of Carcinogenesis and Translational Research (Ministry of Education) Department of GI Oncology Peking University School of Oncology Beijing Cancer Hospital & Institute Beijing 100142 China Department of General Surgery; The First Affiliated Hospital of Nanjing Medical University; Nanjing 210029; China College of Materials Science and Engineering; Taiyuan University of Technology; Taiyuan; P.R. China College of Animal Science and Technology, Shihezi University , Shihezi , Xinjiang , China Institute for Population and Development Studies, School of Public Policy and Administration, Xi'an Jiaotong University, Xi’an 710049, China; Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China Department of Biological Sciences, Dartmouth College, Hanover, New Hampshire 03755 (M.G.M., G.E.S); Department of Biochemistry and Molecular Biology (J.L.) and Department of Plant Biology (D.E.M.), University of New Hampshire, Durham, New Hampshire 03824; and Department of Biology, University of North Carolina, Chapel Hill, North Carolina 27599 (J.J.K.) Department of Oncology, Shanghai Changhai Hospital, No. 168 Changhai Road, Shanghai, 200433, China Department of Computer Science and Technology, Tongji University, No. 4800 Caoan Highway, Shanghai 200092, China Department of General Surgery, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, China. Energy and Semiconductor Research Laboratory, Department of Physics, Carl von Ossietzky University of Oldenburg, 26129 Oldenburg, Germany Department of Surgery, Shanghai Key Laboratory of Gastric Neoplasms, Shanghai Institute of Digestive Surgery, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200025, People's Republic of China Department of Ophthalmology, Boston Children’s Hospital, Harvard Medical School, Boston, MA 02115;; Department of Ophthalmology, Sichuan Provincial People's Hospital and Sichuan Academy of Medical Science, Chengdu, Sichuan 610027, China School of Basic Medical Sciences & Forensic Medicine Hangzhou Medical College Hangzhou China Ocean University of China College of Information Science and Engineering, , 238 Song Ling Road, Qingdao 266100, China julin97@gmail.com , jennyprc89@gmail.com , 1241137284@qq.com , wangyu@public.qd.cn Department of Laparoscope Surgery, 986 Hospital of People’s Liberation Army Air Force, Xi’an 719000, China Department of Ultrasound, Qilu Hospital; Shandong University; Jinan China State Key Laboratory of Grassland Agro‐ecosystems Key Laboratory of Grassland Livestock Industry Innovation, Ministry of Agriculture and Rural Affairs Engineering Research Center of Grassland Industry, Ministry of Education College of Pastoral Agriculture Science and Technology Lanzhou University Lanzhou China Department of Laboratory Medicine, Taihe Hospital, Hubei University of Medicine, Shiyan, China. Key Lab of Polyoxometalate Science; Department of Chemistry; Northeast Normal University; Changchun 130024; China College of Resources and Environment, Huazhong Agricultural University, Wuhan 430070, China School of Environmental and Municipal Engineering, Lanzhou Jiaotong University, Lanzhou, China; Key laboratory of Yellow River Water Environment in Gansu Province, Lanzhou, China Division of Respiratory Care, Department of Cardiopulmonary Sciences, Rush University Medical Center, Chicago, Illinois, USA. Beijing National Laboratory for Molecular Sciences, Key Laboratory of Molecular Nanostructure and Nanotechnology, CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing, P.R. China. Reproductive Medical Center Renmin Hospital of Wuhan University Wuhan China Department of Molecular Pharmacology, City of Hope National Medical Center, Duarte, California, USA Experimental Hematology and Cancer Biology, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH; Departments of Neurology and Physiology/Pharmacology, SUNY Downstate, Brooklyn, NY, USA National Key Laboratory for Crop Genetics and Germplasm Enhancement Jiangsu Plant Gene Engineering Research Center Nanjing Agricultural University Nanjing China Center for Medicine Research and Translation, Chengdu Fifth People’s Hospital (The Second Clinical Medical College, Affiliated Fifth People’s Hospital of Chengdu University of Traditional Chinese Medicine), Chengdu 611135, Sichuan, China; Cancer Prevention and Institute of Chengdu, Department of Oncology, Chengdu Fifth People’s Hospital (The Second Clinical Medical College, Affiliated Fifth People’s Hospital of Chengdu University of Traditional Chinese Medicine), Chengdu 611130, Sichuan, China Department of Anesthesiology, Pain Research Center, University of Cincinnati Medical Center, Cincinnati, OH, United States Department of UAV Engineering, Mechanical Engineering College, Shijiazhuang 050003, China Department of Pharmacy Shanghai Sixth People's Hospital Affiliated Shanghai Jiao Tong University School of Medicine Shanghai 200233 China Combination Department, Beijing Chest Hospital, Beijing 101149, China. Department of Hepatobiliary Surgery, Fujian Provincial Key Laboratory of Chronic Liver Disease and Hepatocellular Carcinoma (Xiamen University Affiliated ZhongShan Hospital), Xiamen, Fujian China Department of Energy, Politecnico di Milano, Campus Bovisa - Via Lambruschini 4a, Milan, 20156, Italy Department of Radiology and Medical Imaging University of Virginia Charlottesville VA Research Center of Laser Fusion; China Academy of Engineering Physics; Mianyang 621900; China Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, China College of Animal Science and Technology, Northwest A&F University, Yangling, China Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of the Ministry of Education, College of Chemistry and Materials Science, Northwest University, Xi’an, 710069, P. R. China Department of Radiation Oncology, Biologic Therapeutics Center, Washington University School of Medicine, St. Louis, Missouri, USA Department of Pediatrics, Washington University School of Medicine, St. Louis, MO 63110, U.S.A. Pain Research Center Department of Anesthesiology University of Cincinnati Medical Center Cincinnati Ohio 45267 Department of Otorhinolaryngology,Fuxing Hospital,Capital Medical University,Beijing,100038,China. Department of Hematology, Children's Hospital of Soochow University, Suzhou, People’s Republic of China Shanghai Applied Radiation Institute, State Key Laboratory Advanced Special Steel, Shanghai University, Shanghai 200444, P. R. China The First College of Clinical Medicine Nanjing Medical University Nanjing Jiangsu P.R. China; Department of General Surgery The First Affiliated Hospital of Nanjing Medical University Nanjing Jiangsu P.R. China The Third Hospital of Hebei Medical University, Shijiazhuang, P. R. China Key Laboratory of Gene Engineering of the Ministry of Education, State Key Laboratory of Biocontrol, Sun Yat-Sen (Zhongshan) University, Guangzhou 510275, People's Republic of China Department of Gastrointestinal Surgery and Institute of Clinical Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan 450003, P.R. China Department of Neurology,Tangdu Hospital, Fourth Military Medical University, Xi'an 710038, China. Institute of TBI and Neuroscience of Chinese People's Armed Police Force, Tianjin Key Laboratory of Neurotrauma Repair, Center for Neurology and Neurosurgery of Affiliated Hospital of Logistics University of PAP, Tianjin 300162, P.R. China Department of Immunology, Cancer Institute & Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100021, China Key Laboratory of Analytical Chemistry for Life Science (Education Ministry of China), School of Chemistry and Chemical Engineering and Center of Materials Analysis, Nanjing University, 22 Hankou Road, Nanjing, Jiangsu Province 210093, China, and School of Public Health, Nanjing Medical University, 140 Hanzhong Road, Nanjing, Jiangsu Province 210029, China Department of Breast and Thyroid Surgery, The First Affiliated Hospital of Sun Yat‑sen University, Guangzhou, Guangdong 510080, P.R. China Key Laboratory of Combined Multi-Organ Transplantation, Ministry of Public Health, Hangzhou, China School of Biotechnology, Jiangnan University, 1800 Lihu Road, Wuxi, Jiangsu 214122, China Department of Hepatobiliary and Pancreatic Surgery The First Affiliated Hospital of Zhengzhou University Zhengzhou Henan China; Open and Key Laboratory of Hepatobiliary & Pancreatic Surgery and Digestive Organ Transplantation at Henan Universities Zhengzhou Henan China; Henan Key Laboratory of Digestive Organ Transplantation Zhengzhou Henan China Department of Pharmacy, Zhangjiagang TCM Hospital, Affiliated to Nanjing University of Chinese Medicine, Zhangjiagang, Jiangsu, China Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, China Department of Neurology The Fourth Affiliated Hospital of China Medical University Shenyang China State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, P. R. China Sugarcane Research Institute, Yunnan Academy of Agricultural Sciences, Yunnan Key Laboratory of Sugarcane Genetic Improvement, Kaiyuan 661699, P.R. China State Key Laboratory of Materials-Oriented Chemical Engineering, College of Chemical Engineering, Nanjing Tech University, Nanjing 210009, China; National Engineering Research Center for Special Separation Membrane, Nanjing Tech University, Nanjing 210009, China State Key Laboratory of Quality Research in Chinese Medicine Macau Institute for Applied Research in Medicine and Health Macau University of Science and Technology Taipa Macau S.A.R. 999078 China Department of Dermatology, Xiangya Hospital, Central South University, Xiangya Road #87 Changsha, Hunan, China, 410008; Hunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Central South University, Xiangya Road #87 Changsha, Hunan, China, 410008 Key Laboratory for Organic Electronics and Information Displays & Jiangsu Key Laboratory for Biosensors; Institute of Advanced Materials (IAM); Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM); Nanjing University of Posts & Telecommunications; Nanjing 210023 College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, ZJ 310058, China Key Laboratory of Functional Polymer Materials of Ministry of Education Institute of Polymer Chemistry Tianjin Key Laboratory of functional polymer materials College of Chemistry Nankai University Tianjin 300071 China Department of Infectious Diseases, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong Province, China Department of Microbiology, Molecular Biology, and Biochemistry, University of Idaho, Moscow, Idaho 83844 Key Laboratory for Feed Biotechnology of the Ministry of Agriculture Feed Research Institute, Chinese Academy of Agricultural Sciences Beijing 100081 People's Republic of China Department of Metabolic Biology, John Innes Centre, Norwich, UK Department of Clinical Research Center Dazhou Central Hospital Dazhou Sichuan China Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139;; Institute for Soldier Nanotechnologies, Massachusetts Institute of Technology, Cambridge, MA 02139 Key Laboratory of Optic-electric Sensing and Analytical Chemistry for Life Science, MOE, Shandong Key Laboratory of Biochemical Analysis, Key Laboratory of Analytical Chemistry for Life Science in Universities of Shandong, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, P.R. China Scripps Institution of Oceanography; University of California; San Diego, La Jolla; USA; Department of Chemistry and Biochemistry Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery, Miller School of Medicine University of Miami Miami Florida USA Pain Research Center, Department of Anesthesiology, University of Cincinnati Medical Center, 231 Albert Sabin Way, Cincinnati, OH 45267, USA From the Departments of 1Ophthalmology and 3Pharmacology and Therapeutics, College of Medicine, University of Florida, Gainesville, Florida; 2Department of Cell Biology and Anatomy, University of North Texas, Fort Worth, Texas; 4Department of Genetics, Ki College of Geography and Environment, Shandong Normal University, Jinan 250358, China National Digital Switching System Engineering and Technological Research Center, Zhengzhou, P.R. China Authors' Affiliations: 1Massachusetts General Hospital Cancer Center; 2Department of Medicine, Harvard Medical School, Boston, Massachusetts; 3Genomics Institute of the Novartis Research Foundation, San Diego, California; 4Cancer Chemotherapy Center and 5Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan Department of Central Laboratory, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China Department of Ophthalmology, University of Florida, Gainesville, Florida, United States State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, People’s Republic of China Department of Pediatric Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Department of Genetics, School of Basic Medical Sciences Tianjin Medical University Tianjin China Department of Neurology, The People's Hospital of Deyang City Department of Geriatrics the First Hospital of Jilin University Changchun China Urology, Affiliated Hospital of Xuzhou Medical University, Xuzhou 221002, People’s Republic of China Department of Chemistry, University of California, One Shields Ave, Davis, CA 95616, USA Department of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan, China; Hunan Key Laboratory of Skin Cancer & Psoriasis, Xiangya Hospital, Central South University, Changsha, Hunan, China 1The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, China.; 2Key Laboratory of Protein and Peptide Pharmaceuticals, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China. College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, China; Guangdong Provincial Key Laboratory of Optical Fiber Sensing and Communications, Institute of Photonics Technology, Jinan University, Guangzhou 511443, China Key laboratory of Carcinogenesis and Translational Research (Ministry of Education) Department of GI Oncology Peking University Cancer Hospital & Institute Beijing China Department of Physiology Anhui Medical University Hefei Anhui P. R. China Department of Hepatobiliary Surgery, Zibo Central Hospital, Zibo, Shandong 255036, P.R. China Department of Respiratory Medicine Jiangyin School of Clinical Medicine Jiangsu University Jiangyin Jiangsu China Department of Information Management,PUMC Hospital, CAMS and PUMC,Beijing 100730,China. Department of Nuclear Medicine and Huaxi MR Research Center Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, PR China Pharmacy College, Chengdu University of Traditional Chinese Medicine Chengdu 611137, China. College of Life Science, Liaocheng University, Liaocheng 252000, China College of Horticulture/Yuelushan Lab/Whampoa Innovation Research Institute Hunan Agricultural University Changsha Hunan China; Key Laboratory for Evaluation and Utilization of Gene Resources of Horticultural Crops (Vegetables, Tea, etc.), Ministry of Agriculture and Rural Affairs of China Changsha China Department of General Surgery; Qianfoshan Hospital; Shandong University; Jinan China Department of Clinical Medical Laboratory Peking University Shenzhen Hospital Shenzhen China Technical Centre of Rongcheng Customs District Fuzhou China 1Department of Gastrointestinal Oncology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital and Institute, Beijing, China. Center for Theoretic and Applied Neuro-Oncology, Division of Neurosurgery, University of California, San Diego, CA, USA Center for Reproductive Medicine Wuhan University Renmin Hospital, Hubei Clinic Research Center for Assisted Reproductive Technology and Embryonic Development Wuhan Hubei China Key Laboratory of Applied Surface and Colloid Chemistry, Ministry of Education, School of Chemistry and Materials Science, Shaanxi Normal University, Xi'an, 710062, People's Republic of China, and National Engineering Research Center of Chiral Drugs and Key Laboratory of Asymmetric Synthesis and Chirotechnology of Sichuan Province, Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041, People's Republic of China xuedong_welcome@snnu.edu.cn; jgdeng@cioc.ac.cn First School of Clinical Medicine Shandong University of Traditional Chinese Medicine Jinan China Department of Chemistry, Paderborn University, Warburgerstraße 100, D-33098 Paderborn, Germany College of First Clinical Medicine, Shandong University of Traditional Chinese Medicine Jinan Shandong People's Republic of China Department of Geriatrics, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China Department of Allergy, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430030 Wuhan, China Department of Infectious Diseases,Nanjing Drum Tower Hospital,The Affiliated Hospital of Nanjing University Medical School,Nanjing,China; Institute of Viruses and Infectious Diseases,Nanjing University,Nanjing,China Department of Infectious Disease Shandong Provincial Hospital Affiliated to Shandong University Ji'nan Shandong China; Division of Gastroenterology and Hepatology Stanford University Medical Center Stanford CA USA Department of UrologyFirst Affiliated HospitalChongqing Medical UniversityChongqingChina Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA 94305-5453;; Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305-5453; Department of Hepatobiliary Surgery, The First Affiliated Hospital of Shandong First Medical University, Jinan, Shandong 250014, P.R. China 1Department of Laboratory Medicine, Huangyan Hospital of Wenzhou Medical University, Taizhou First People’s Hospital, Taizhou, Zhejiang Province, China Department of Ultrasound, Qilu Hospital of Shandong University, Jinan, China Cancer Center Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430022 China Department of Pharmacy; Shanghai No. 6 People's Hospital, Shanghai Jiaotong University; Shanghai China Cancer Prevention and Treatment Institute of Chengdu, Center for Medicine Research and Translation, Chengdu Fifth People’s Hospital/The Second Clinical Medical College, The Affiliated Fifth People’s Hospital of Chengdu University of Traditional Chinese Medicine Chengdu 611137, P. R. China Department of Plastic and Reconstructive Surgery, Shanghai 9th People's Hospital Shanghai Tissue Engineering Key Laboratory, Shanghai Jiao Tong University School of Medicine, 639 Zhi Zao Ju Road Shanghai 200011 China; Plastic Surgery Hospital, Chinese Academy of Medical Sciences Peking Union Medical Collage, 33 Ba Da Chu Road Beijing 100144 China School of Life Sciences, Tsinghua University, Beijing, China; IDG/McGovern Institute for Brain Research at Tsinghua University, Beijing, China Guangzhou Key Laboratory of Environmental Pollution and Health Risk Assessment, Department of Toxicology, School of Public Health, Sun Yat-sen University, Guangzhou, China; Department of Pharmacy, School of Medicine, Zhejiang University City College, No. 48, Huzhou Road, Hangzhou 310015, Zhejiang, China State Key Laboratory of Microbial Resources Institute of Microbiology, Chinese Academy of Sciences, No.1 Beichen West Road, Chaoyang District Beijing 100101 China Department of Neurology and VIP Ward, The First Affiliated Hospital of Soochow University, Suzhou, China. Department of Neuropathology, Yale School of Medicine, New Haven, Connecticut 06520, United States Department of Otorhinolaryngology Head and Neck Surgery,Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai,200233,China. CAS Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China Vascular Biology Center Medical College of Georgia Augusta University Augusta Georgia College of Materials Science and Engineering, Zhejiang University of Technology, Hangzhou, China; Department of Urology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China. School of Physics and Mechanical & Electronical Engineering; Institute for Functional Materials; Hubei University of Education; Wuhan 430205; P. R. China Department of Hepatobiliary Surgery, Fuyang People’s Hospital, Fuyang, Anhui, China College of Biomass Science and Engineering, Sichuan University, Chengdu 610065, China. Xi’an Jiaotong University Department of Pharmacy, First People’s Hospital, Jining, Shandong, China (mainland) Institute of Photonics and Photon‐Technology Northwest University Xi'an Shaanxi China Department of Chemical Physics, University of Science and Technology of China, Hefei 230026, China College of Life Sciences and Medicine, Zhejiang Province Key Laboratory of Plant Secondary Metabolism and Regulation, Zhejiang Sci-Tech University, Hangzhou, China State Key Laboratory of Bioactive Molecules and Druggability Assessment, Jinan University, 601 Huangpu Avenue West, Guangzhou 510632, China; International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development (MOE), Jinan University, 601 Huangpu Avenue West, Guangzhou 510632, China; School of Pharmacy, Jinan University, 601 Huangpu Avenue West, Guangzhou 510632, China Department of Respiratory Diseases, Second Clinical medical college (Shenzhen People’s Hospital), Jinan University, Shenzhen, China;; Integrated Chinese and Western Medicine Postdoctoral research station, Jinan University, Guangzhou, China; Breast Disease Center, The First Affiliated Hospital Sun Yat‐Sen University Guangzhou China Department of Oncology, Changhai Hospital, Naval Medical University, Shanghai 200433, P.R. China Institut für Organische und Biomolekulare Chemie Georg-August-Universität Göttingen Tammannstrasse 2 37077 Göttingen Germany Department of Infectious Diseases, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School Nanjing University Nanjing Jiangsu China Department of Breast and Thyroid Surgery, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China; Division of Thyroid and Parathyroid Endocrine Surgery, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA 02114, USA The First School of Clinical Medicine, Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China Department of Molecular Medicine The Scripps Research Institute La Jolla CA 92037 USA School of Geography and Remote Sensing, Guangzhou University, Higher Education Mega Center, Guangzhou, 510006, China. School of Electronic Engineering, Xidian University, Xi’an, China College of Life Sciences University of Chinese Academy of Sciences Beijing 100049 China; China National GeneBank BGI‐Shenzhen Shenzhen 518120 China; BGI‐Shenzhen Shenzhen 518083 China Department of Special Requirements Ward, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, P.R. China Department of Infectious Diseases, Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School , Nanjing, Jiangsu, 210008 , China 1 State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032 and 2 State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Macau, People’s Republic of China Key Laboratory of Modern Toxicology, Shenzhen Center for Disease Control and Prevention, Shenzhen, China Ludwig-Maximilians-Universität München, Department Chemie und Biochemie Department of Mechanical and Aerospace Engineering The Hong Kong University of Science and Technology Clear Water Bay Hong Kong P. R. China Department of Orthopaedics, The First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine, Guangzhou City, Guangdong Province, China Jinshi Technology Co. Ltd. 289 Longquanyi District Chengdu 610100 China Department of Pathology, Chinese People’s Liberation Army General Hospital, China College of Animal Science and Technology, Shaanxi Key Laboratory of Molecular Biology for Agriculture, Northwest A&F University, Yangling, Shaanxi, P. R. China; Department of Microbiology, Yongchuan Hospital of Chongqing Medical University, Chongqing, China Department of Hepatobiliary Surgery, Zhongshan Hospital, Xiamen University, Fujian Provincial Key Laboratory of Chronic Liver Disease and Hepatocellular Carcinoma (Xiamen University Affiliated Zhongshan Hospital), Xiamen, Fujian, China College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China Department of Oncology, Mianyang Central Hospital, Mian Yang, People's Republic of China South China Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Guangzhou, China; Key Laboratory of Open-Sea Fishery Development, Ministry of Agriculture and Rural Affairs, Guangzhou, China State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, Hunan 410082, People’s Republic of China School of Naval Architecture, Ocean and Civil Engineering, Shanghai Jiao Tong University, Shanghai, China Department of Cell Biology and Physiology, University of Pittsburgh, Pittsburgh, Pennsylvania;; Department of Endocrinology, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China; Department of Cardiology of People’s Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang, China Department of Neonatology, Children’s Hospital of Soochow University, Suzhou, Jiangsu 215025, China Charles M. Baugh Biomedical Library, University of South Alabama, Mobile, Alabama, USA College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, Shandong 250014, P. R. China CAS Key Laboratory of Tropical Marine Bio‐resources and Ecology, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences Guangzhou Guangdong P. R. China Department of Neurology, State Key Laboratory of Complex Severe and Rare Disease, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100730, China Pearl River Fisheries Research Institute, Chinese Academy of Fishery Sciences Guangzhou China Department of Systems Biology and Gynecologic Medical Oncology, University of Texas, M.D. Anderson Cancer Center, Houston, TX, USA Department of Chemistry and Key Laboratory for Preparation and Application of Ordered Structural Materials of Guangdong Province, Shantou University, Shantou, Guangdong Province 515063, P. R. China Department of Chinese Materia Medica and Natural Medicines, School of Pharmacy, The Air Force Medical University, Xi’an, 710032 Shaanxi, China Department of Electrical Engineering, The Pennsylvania State University, State College, University Park, Pennsylvania 16802, United States Department of Neurology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science/Peking Union Medical College, Beijing, China Guangdong Cardiovascular Institute, Guangdong General Hospital, Guangdong Academy of Medical Science, China Hefei National Laboratory for Physical Science at the Microscale School of Life Sciences University of Science and Technology of China Hefei Anhui 230027 China Department of Immunology, University of South Florida, Tampa, USA School of Nursing, Shandong University, Jinan Department of Respiratory and Critical Care Medicine, Frist Hospital of Qinhuangdao, Hebei, China School of Chemistry and Chemical Engineering, Central South University, Changsha410083, China School of Nursing Peking University Beijing China Institute of Resources, Ecosystem and Environment of Agriculture Nanjing Agricultural University Nanjing China John Innes Centre Norwich UK Beijing National Laboratory for Molecular Sciences State Key Laboratory for Structural Chemistry of Unstable and Stable Species College of Chemistry and Molecular Engineering Peking University Beijing 100871 P. R. China; Key Laboratory of Radiopharmaceuticals Ministry of Education College of Chemistry Beijing Normal University Beijing 100875 P. R. China Department of Ultrasound, The First College of Clinical Medical Sciences, China Three Gorges University *Chinese Academy of Sciences (CAS) Key Laboratory of Innate Immunity and Chronic Disease, CAS Center for Excellence in Molecular Cell Science, School of Life Sciences and Medical Center, University of Science and Technology of China, Hefei 230027, China; Department of Infectious Diseases Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School Nanjing Jiangsu China Department of Traditional Chinese Medicine, National Cancer Center/National Clinical Research Center for Cancer/ Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China SINOPEC (Beijing) Research Institute of Chemical Industry Co., Ltd., 14 Beisanhuan East Road, Chaoyang District, Beijing 100013, China Key Laboratory of Organic Synthesis of Jiangsu Province College of Chemistry Chemical Engineering and Materials Science Soochow University 199 Ren‐Ai Road Suzhou Jiangsu 215123 China ShanghaiTech University, Shanghai 201210, China Laboratory of Molecular Iron Metabolism, Key Laboratory of Molecular and Cellular Biology of the Ministry of Education, Key Laboratory of Animal Physiology, Biochemistry and Molecular Biology of Hebei Province, College of Life Sciences Hebei Normal University Shijiazhuang China Department of Vascular Surgery, First Affiliated Hospital, Sun Yat-Sen University Guangzhou, China College of Animal Science and Technology, Yangzhou University, Yangzhou, China *Institute of Molecular and Cell Biology, Singapore 138673, Singapore; and School of Materials Science & Engineering, University of Shanghai for Science & Technology, Shanghai 200093, China Department of Emergency Medicine, Fuxing Hospital, Capital Medical University Department of Gastrointestinal Oncology, Key Laboratory of Carcinogenesis and Translational Research, Ministry of Education, Peking University School of Oncology, Beijing Cancer Hospital and Institute, Beijing, China Department of Anesthesiology, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, China The State Key Laboratory of Pharmaceutical Biotechnology and Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology , NJU Advanced Institute for Life Sciences (NAILS), School of Life Science, Nanjing University, Nanjing 210093, China State Key Laboratory of Grassland Agro‐Ecosystems, Key Laboratory of Grassland Livestock Industry Innovation Ministry of Agriculture and Rural Affairs Engineering Research Center of Grassland Industry Ministry of Education College of Pastoral Agriculture Science and Technology Lanzhou University Lanzhou China Department of Implantology School/Hospital of Stomatology Lanzhou University Lanzhou Gansu China Department of Endocrinology, Jinling Hospital, Medical School of Nanjing University, 305 East Zhongshan Road, Nanjing, Jiangsu 210002, China Department of Obstetrics and Gynecology Qilu Hospital Shandong University Jinan China; Gynecology Oncology Key Laboratory Qilu Hospital Shandong University Jinan China From Cardiovascular Research Center, School of Basic Medical Sciences, Xi’an Jiaotong University Health Science Center, China (Z.L., Jin Zhang, L.B., Jiao Zhang, M.H., J.L., T.L., J.Y.-J.S.); Key Laboratory of Environment and Genes Related to Diseases, Xi’an Jiaotong University, Ministry of Education of China (Z.L., Jin Zhang, L.B., Jiao Zhang, M.H., J.L., T.L., J.Y.-J.S.); Division of Cardiology, Department of Medicine, University of California, San Diego, La Jolla (M.M., Jin Zhang, J.K., M.H., Y.... Ordered Matter Science Research Center Jiangsu Key Laboratory for Science and Applications of Molecular Ferroelectrics Southeast University Nanjing 211189 P.R. China Department of Chemistry and Biochemistry, University of California, Santa Cruz, California 95064 Department of General Surgery Siyang Hospital Suqian China Department of Neurology, The Second Affiliated Hospital, Harbin Medical University, Harbin, China Department of Orthopedic and Traumatology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China (mainland) School of Water Conservancy and Civil Engineering, Zhengzhou University, Zhengzhou 450001, China Pomology Institute, Shanxi Academy of Agricultural Sciences, Taigu, China. Shanghai Key Laboratory of Metabolic Remodeling and Health, Department of Chemistry and Institute of Metabolism and Integrative Biology, Fudan University, Shanghai 200032, China Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, People’s Republic of China; The Second Affiliated Hospital of Harbin Medical University, Harbin, China Cardiovascular Center Beijing Tongren Hospital, Capital Medical University Beijing China From the Institute of Ocular Pharmacology, School of Ophthalmology and Optometry, Wenzhou Medical College, Zhejiang, China; the Research Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, 211166, Jiangsu, China; Department of Bioinformatics, Nanjing Medical University, 101 Longmian Avenue, Jiangning District, Nanjing, 211166, Jiangsu, China; Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Personalized Cancer Medicine, Nanjing Medical University, Nanjing, 211166, Jiangsu, China Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China National Clinical Research Center for Oral Diseases, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai Key Laboratory of Stomatology and Shanghai Research Institute of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai, China Department of Hepatobiliary and Pancreatic Surgery, The Affiliated Hangzhou First Hospital, Zhejiang University School of Medicine, Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province, Hangzhou, Zhejiang 310006, China Department of Orthopedics Ningbo Medical Center Lihuili Hospital Ningbo China 4Cancer Epidemiology Services, New Jersey Department of Health, Trenton, New Jersey. Department of Respiratory Medicine, Affiliated Jiangyin Hospital of Southeast University Medical College, Jiangyin, China. Department of Chemistry Massachusetts Institute of Technology (MIT) Cambridge MA 02139 USA College of Food Science and Nutritional Engineering China Agricultural University No. 17, Qinghua East Road Beijing 100083 China; Key Laboratory of Precision Nutrition and Food Quality Beijing Laboratory for Food Quality and Safety Department of Nutrition and Health China Agricultural University Beijing 100191 China Department of Pathologic Physiology, College of High Altitude Military Medicine, The Third Military Medical University (Army Medical University), Chongqing, China Department of Chemistry and Biochemistry University of South Carolina, Columbia South Carolina 29208 USA The Second Affiliated Hospital of Zhengzhou University, Radiology Department, Zhengzhou 450000, Henan, China Department of Neurology, Drum Tower Hospital of Nanjing Medical University, Nanjing, Jiangsu, P. R. China; Department of Neurology, Affiliated Yixing People’s Hospital of Jiangsu University, Yixing City, Jiangsu, China Cardiovascular Research Center, School of Basic Medical Sciences, Xi’an Jiaotong University Health Science Center, Key Laboratory of Environment and Genes Related to Diseases, Xi’an Jiaotong University, Ministry of Education of China Xi’an, 710029 Xi’an, China; Department of Neurology, Second Affiliated Hospital, Soochow University, Suzhou 215004, China. School of Metallurgy and Environment, Engineering Research Center of the Ministry of Education for Advanced Battery Materials, Central South University, Changsha 410083, China Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, OH; and From the Departments of *Nuclear Medicine, and †Pathology, Chinese PLA General Hospital, Beijing, China. Department of Energy Politecnico di Milano Via Lambruschini, 4 Milano MI-20156 Italy From the Department of Medicine and the Zena and Michael A. Wiener Cardiovascular Institute (J.X.R., J.L., E.D.R., R.P.C., V.I.E., J.T.F., E.A.F.) and the Department of Surgery (E.D.R.), Mount Sinai School of Medicine; and the Laboratory of Biochemical Genetics and Metabolism, Rockefeller University (H.M.D., J.L.B.), New York, NY. State Key Laboratory of Cellular Stress Biology, Key Laboratory of the Ministry of Education for Coastal and Wetland Ecosystems, School of Life Sciences; Xiamen University; Xiamen Fujian People's Republic of China Department of Obstetrics and Gynecology, Taizhou Hospital of Zhejiang Province, Taizhou Enze Medical Center (Group), Linhai, Zhejiang Province, China Authors' Affiliations: Departments of 1Systems Biology, 2Bioinformatics and Computational Biology, 3Gynecologic Oncology, and 4Pathology, The University of Texas MD Anderson Cancer Center; 5Department of Molecular and Human Genetics, Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas; 6Department of Medical Oncology, Beaumont Hospital; 7Royal College of Surgeons of Ireland, Dublin, Ireland; 8Division of Women's Cancers, Department of Medical Oncology, Dana-Farber Cancer Institute; 9Division of Signal Transduction, Department of Medicine, Beth Israel Deaconess Medical Center; 10Department of Systems Biology, Harvard Medical School, Boston, Massachusetts; and 11Department of Pathology and Laboratory Medicine, University of Ottawa, Ottawa, Ontario, Canada The First School of Clinical Medicine Nanjing Medical University Nanjing China; Department of General Surgery The First Affiliated Hospital of Nanjing Medical University Nanjing China College of Materials Science and Engineering Zhejiang University of Technology Hangzhou Zhejiang 310014 China ProteinT Biotechnologies, Co. Ltd., Tianjin, China Genome Center and Department of Biomedical Engineering, University of California at Davis, One Shields Avenue, Davis, California 95616, United States From the Division of Inflammation Biology (J.L., S.M., T.K., D.W., T.G., J.M., K.L.) and Bioinformatics Core (A.G.), La Jolla Institute for Allergy & Immunology, CA; Institute for Cardiovascular Prevention, Ludwig-Maximilians-University Munich, Munich, Germany (C.W.); and DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany (C.W.). Department of Surgery, University of Michigan, Ann Arbor, MI, USA Department of Dermatology and Cutaneous Surgery University of Miami Miller School of Medicine Miami Florida Red Cell Physiology Laboratory, New York Blood Center, New York, NY; Department of Electrical and Computer Engineering, Michigan State University , East Lansing, Michigan 48823 Cancer Centre and Institute of Translational Medicine Faculty of Health Sciences University of Macau Taipa Macau SAR 999078 China; MoE Frontiers Science Center for Precision Oncology University of Macau Taipa Macau SAR 999078 China Department of Neurology, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150086, China Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700. lijie2007@126.com Department of Infectious Disease, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, People's Republic of China. Sichuan Provincial Engineering Research Center of City Solid Waste Energy and Building Materials Conversion & Utilization Technology, Key Laboratory of Drinking Water Source Protection in Chengdu Basin of Sichuan Province, Chengdu University, Chengdu 610106, China Department of Critical Care Nephrology and Blood Purification The First Affiliated Hospital of Xi'an Jiaotong University Xi'an Shannxi China People's Hospital of Deyang City; Department of Neurology; No.173, Taishan North Road Deyang Sichuan China 618000; West China Hospital, Sichuan University; Department of Neurology; No. 37, Guo Xue Xiang Chengdu Sichuan China 610041 Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Gastrointestinal Oncology Peking University Cancer Hospital & Institute Beijing China Department of Biochemistry and Molecular Biology, Michigan State University, 603 Wilson Road, East Lansing, Michigan 48824, United States Hunan University of Chinese Medicine, Changsha, 410208 Hunan Province, China; Hunan Provincial Key Laboratory for the Prevention and Treatment of Ophthalmology and Otolaryngology Diseases with Chinese Medicine, Changsha, 410208 Hunan Province, China Department of Orthopaedics, First Affiliated Hospital of Guangzhou Traditional Chinese Medicine University Guangzhou Guangdong China College of Pharmacy, Second Military Medical University, Shanghai 200433, China Department of Radiation Oncology, Xijing Hospital School of Food and Biological Engineering, Jiangsu University, 301 Xuefu Road, Zhenjiang 212013, Jiangsu, China *Department of Geology, University of Illinois at Urbana–Champaign, 1301 West Green Street, Urbana, IL 61801; Department of Hematology, The Second Artillery General Hospital, Beijing 100088, China. Department of Thoracic Surgery, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinshi District, China Key Laboratory of Diagnosis and Treatment of Severe Hepato-Pancreatic Diseases of Zhejiang Province, The First Affiliated Hospital of Wenzhou Medical University , Wenzhou, 325000 , China Department of Neurology, Affiliated Yixing Hospital of Jiangsu University/Affiliated Yixing Clinical School of Medical School of Yangzhou University, Yixing, Jiangsu Province, Peoples’ Republic of China Department of Chemistry, Brandeis University, 415 South Street, Waltham, Massachusetts 02454, United States Department of Nephrology, Yongchuan Hospital of Chongqing Medical University, Chongqing, China (mainland) Australian Centre for Water and Environmental Biotechnology, The University of Queensland , St Lucia, QLD, Australia Department of Pharmacy, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, Shanghai, China Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials; Department of Chemistry; Fudan University; Shanghai; China School of Food and Biological Engineering, Jiangsu University, 301 Xuefu Road, Zhenjiang 212013, China Institute for Infectious Disease and Endemic Disease Control, Beijing Center for Disease Prevention and Control (CDC), Beijing 100013, China Department of Ultrasound, Qilu Hospital, Shandong University, Jinan 250012, China Department of Oncology, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, No. 5 Beixiange, Xicheng District, Beijing 100053, China 5Beijing Key Laboratory of DNA Damage Response and College of Life Sciences, Capital Normal University, Beijing, China. Department of Radiation Oncology, Xijing Hospital , Fourth Military Medical University . Xi’an , China Genomics Institute of the Novartis Research Foundation, San Diego, CA 92121; Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, United States Cancer Center Faculty of Health Sciences University of Macau Macau SAR, 999078 China; Institute of Translational Medicine Faculty of Health Sciences University of Macau Macau SAR, 999078 China The Austin Research Institute, Kronheimer Building, Austin Health, Studley Road, Heidelberg 3084, Victoria, Australia. Department of Orthopaedics, Sir Run Run Shaw Hospital Affiliated to Zhejiang University School of Medicine, Hangzhou 310016, Zhejiang, China. Department of Cardiopulmonary Sciences, Division of Respiratory Care, Rush University Medical Center, Chicago, IL. 60612, USA. Pulmonary and critical care medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing Institute of Respiratory Medicine, Beijing 100020, PR China. CAS Key Laboratory of Urban Pollutant Conversion, Department of Applied Chemistry, University of Science and Technology of China, Hefei 230026, China; University of Science and Technology of China-City University of Hong Kong Joint Advanced Research Center, Suzhou 215123, China; State Key Laboratory in Marine Pollution, Department of Chemistry, City University of Hong Kong, Kowloon 999077, Hong Kong SAR, China Centre for Health Management and Policy, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan 250012, China; NHC Key Laboratory of Health Economics and Policy Research, Shandong University, 44 Wen-hua-xi Road, Jinan, Shandong, 250012, China School of Nursing, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; School of Metallurgy and Environment, Central South University, Hunan Province, Changsha 410083, China; National Engineering Laboratory of High Efficient Recovery of Refractory Nonferrous Metals, Central South University, Hunan Province, Changsha 410083, China Food Laboratory of Zhongyuan, Key Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing, 100193, China College of Traditional Chinese Medicine Shandong University of Traditional Chinese Medicine Jinan China Department of Orthopaedics Southern Medical University Zengcheng Branch of Nanfang Hospital Guangzhou People's Republic of China State Key Laboratory of Biotherapy, West China Hospital and College of Life Sciences, Sichuan University, Chengdu, China Vascular Biology Center (J.L., G.Y., W.M., A.Z., J.Z., H.S.), Medical College of Georgia, Augusta University. School of Metallurgy and Environment, Central South University, Changsha, 410083, PR China; Engineering Research Centre of Advanced Battery Materials, The Ministry of Education, Changsha 410083, Hunan, China; Hunan Provincial Key Laboratory of Value-added Metallurgy, Changsha 410083, Hunan, China Physical and Chemical Analysis laboratory Shanghai Key laboratory of On-line Testing and Control Technology Shanghai Institute of Measurement and Testing Technology 1500 Zhangheng Road Shanghai 201203 China Key Laboratory of Cluster Science, Ministry of Education of China School of Chemistry Beijing Institute of Technology 5 South Zhongguancun Street Beijing 100081 P.R. China Guang’anmen Hospital of China Academy of Chinese Medical Sciences, Beijing 100053, China Department of Orthopedics Zhabei Central Hospital of Jing'an District Shanghai China Calibrant Biosystems, 910 Clopper Road, Suite 220N, Gaithersburg, Maryland 20878, Department of Chemistry and Biochemistry, University of Maryland, College Park, Maryland 20742, Molecular Pathogenesis Unit, Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland 20892, Department of Pathology, University of Arizona, Tucson, Arizona 85724, and Department of Mechanical Engineering and Bioengineering Program, University of Maryland, College Park, Maryland 20742 Guangzhou Municipal Engineering Design and Research Institute, Guangzhou, People's Republic of China School of Electronic Engineering, State Key Laboratory of Integrated Services Networks, Xidian University, Xi’an, China Bioinformatics Core, Genome Center, University of California, Davis, Davis, California 95616, United States *Center for Musculoskeletal Research and; †Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, NY 19642; and Key Lab of Combined Multi‐Organ Transplantation Ministry of Public Health Hangzhou China State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing 210046, People’s Republic of China Beijing Key Laboratory of Cardiopulmonary Cerebral Resuscitation, China Department of Dermatology Xiangya Hospital Central South University Changsha Hunan China; Hunan Key Laboratory of Skin Cancer and Psoriasis Xiangya Hospital Central South University Changsha Hunan China From the Center for Obstetrics and Gynecology, Nanjing Drum Tower Hospital, Nanjing University Medical School, China (Z.W., D.L., Y.D., G.Z., Z.D., C.C., H.L., N.G., H.Z., H.D., J.L., X.Z., H.D., L.S., Q.Z., J.C., H.H., M.Z., Y.H.) Affiliated Hospital of Nanjing University of Chinese Medicine Nanjing 210029, China Jiangsu Province Hospital of Chinese Medicine Nanjing 210029, China. State Key Laboratory of Chemo/Biosensing and Chemometrics, and College of Environmental Science and Engineering, Hunan University, Changsha 410082, People’s Republic of China State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China Department of Spine Surgery, Drum Tower Hospital, Nanjing University Medical School, Nanjing, China Shandong Qihe Biotechnology Co. Ltd. Zibo City Shandong Province China Department of Infectious Diseases, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China. Department of Neurosurgery, University of Minnesota, Minneapolis, Minnesota, USA Key Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM) and School of Flexible Electronics (Future Technologies) Nanjing Tech University (Nanjing Tech) Nanjing 211800 P. R. China Key Laboratory of Radiopharmaceuticals, Ministry of Education, College of Chemistry, Beijing Normal University, Beijing 100875, P. R. China; Beijing National Laboratory for Molecular Sciences, State Key Laboratory for Structural Chemistry of Unstable and Stable Species, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, P. R. China Jiangsu‐Singapore Joint Research Center for Organic/Bio‐Electronics & Information Displays and Institute of Advanced Materials (IAM) Nanjing Tech University Nanjing 211816 China; Key Laboratory for Organic Electronics and Information Displays & Institute of Advanced Materials (IAM) Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM) Nanjing University of Posts & Telecommunications Nanjing 210023 China Institute for Advanced Ceramics, State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, Harbin 150001, PR China Key Laboratory of Tropical Marine Bio‐resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, the South China Sea Institute of Oceanology Chinese Academy of Sciences Guangzhou 510301 China Department of Statistics and Statistical Laboratory, Iowa State University, Ames, Iowa 50011 Department of Clinical Laboratory, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022 Anhui, China Department of Breast and Thyroid Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510080, China Hong Kong Polytechnic University School of Materials Science & Engineering, Beijing Institute of Technology, Beijing 100081, China Department of Orthopaedic Surgery, Sir Run Run Shaw Hospital Affiliated to Medical College of Zhejiang University, Hangzhou 310016, Zhejiang, China. Key Laboratory of Urban Pollutant Conversion, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen 361021, China. University of Chinese Academy of Sciences, Beijing 100049, China. Department of Biochemistry, Tohoku University Graduate School of Medicine, Sendai 980-8575, Japan Department of Orthopedics, Shanxian Central Hospital, Heze, Shandong, China (mainland) Department of Orthopaedics, Xuzhou Central Hospital, Xuzhou Clinical College of Nanjing Medical University, The Affiliated Xuzhou Hospital of Southeast University, Xuzhou, China College of Agronomy, Xinyang Agriculture and Forestry University, Xinyang, Henan Province, China Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore 138673 Department of Pediatric Nephrology and Rheumatology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, P.R. China State Key Laboratory of Hydraulics and Mountain River Engineering, College of Architecture and Environment, Sichuan University, Chengdu 610065, China; Sino-German Centre for Water and Health Research, Sichuan University, Chengdu 610065, China Global Health Research Center, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences , Guangzhou , China; Department of Epidemiology and Center for Global Cardiometabolic Health, School of Public Health, The Warrant Alpert School of Medicine, Brown University , Providence, RI , USA; Department of Medicine, The Warrant Alpert School of Medicine, Brown University , Providence, RI , USA; Department of Surgery, The Warrant Alpert School of Medicine, Brown University , Providence, RI , USA MEET Battery Research Center, Institute for Physical Chemistry, University of Münster, Corrensstraße 46, 48149 Münster, Germany Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, CA 92121 Vascular Biology Center Medical College of Georgia at Augusta University Augusta Georgia USA Department of Laboratory Medicine, Peking University Shenzhen Hospital, Shenzhen, Guangdong Province, People’s Republic of China Genomics Institute of Novartis Research Foundation, San Diego, CA 92121; Department of Urology The First Affiliated Hospital of Nanjing Medical University Nanjing Jiangsu China School of Packaging and Printing Engineering, Tianjin University of Science and Technology, Tianjin 300222, China Department of Hematology and Oncology, Children’s Hospital of Soochow University, Suzhou, China; Jiangxi Province Key Laboratory of Preventive Medicine School of Public Health Department of Cardiovascular Medicine The Second Affiliated Hospital Nanchang University Nanchang P. R. China Department of Clinical Research Center, Dazhou Central Hospital, Dazhou 635000, China Department of Applied Chemistry University of Science and Technology of China Hefei China Department of Marine Biomedicine and Polar Medicine, Naval Special Medical Center, Naval Medical University, Shanghai 200433, China Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, United States; Cancer Biology PhD Program, University of South Florida, Tampa, FL, United States. Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China. zhaojialiang@medmail.com Department of Genetics, Cellular and Developmental Biology, Iowa State University, Ames, IA 50011, USA; Bioinformatics and Computational Biology Program, Iowa State University, Ames, IA 50011, USA *CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China; and Graduate School of Guangdong Medical University, Zhanjiang, China Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, P.R. China; Tianjin Key Laboratory of TCM Chemistry and Analysis, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, P.R. China Hubei Key Laboratory of Agricultural Bioinformatics, College of Informatics, Huazhong Agricultural University, Wuhan 430070, China Jiangsu University Zhenjiang 212013, China National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences Beijing 100700, China. Department of Infectious Diseases, Xiayi County People’s Hospital, Shangqiu City, Henan Province, China Key Laboratory of Particle Astrophysics & Experimental Physics Division & Computing Center, Institute of High Energy Physics, Chinese Academy of Sciences, 100049 Beijing, China.; Tianfu Cosmic Ray Research Center, 610000 Chengdu, Sichuan, China.; State Key Laboratory of Particle Detection and Electronics, China. CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China Department of Computer Science, University of California, Berkeley, CA 94720, USA, 2Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA, 3Red Cell Physiology Laboratory, New York Blood Center, New York, NY 10065, USA, 4Department of Mathematics, University of California, Berkeley, CA 94720, USA and 5Department of Molecular & Cell Biology, University of Californi Departments of Microbiology Department of Laboratory Medicine, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, China (mainland) Joint Disease & Sport Medicine Center , Department of Orthopedics, Xinqiao Hospital, , Chongqing , China , 400038; Army Medical University , Department of Orthopedics, Xinqiao Hospital, , Chongqing , China , 400038 Yancheng City No.1 People's Hospital, Yancheng, China. Department of Hepatobiliary and Pancreatic Surgery The First Affiliated Hospital of Zhengzhou University Zhengzhou Henan China; Henan Key Laboratory of Digestive Organ Transplantation Zhengzhou Henan China Department of Neurosurgery Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine Shanghai China Department of Laboratory Medicine, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China First Clinical Medical College of Shandong University of Traditional Chinese Medicine, Jinan 250014, China Department of Infectious Disease Shandong Provincial Hospital Affiliated to Shandong First Medical University Ji'nan Shandong China; Department of Infectious Disease Shandong Provincial Hospital Affiliated to Shandong University Cheeloo College of Medicine Shandong University Ji'nan Shandong China Department of Neurological Surgery, Shanghai Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China State Key Laboratory of Chemical Resource Engineering, Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, Beijing 100029 People’s Republic of China Key Laboratory for Microbial Resources of the Ministry of Education and Laboratory for Conservation and Utilization of Bio-Resources, Yunnan Institute of Microbiology, Yunnan University, Kunming 650091 Key Laboratory of Coarse Cereal Processing (Ministry of Agriculture and Rural Affairs), Sichuan Engineering & Technology Research Center of Coarse Cereal Industralization, School of Food and Biological Engineering, Chengdu University, Chengdu 610106, China School of Microelectronics Southern University of Science and Technology Shenzhen 518000 China School of Chemistry National and Local Joint Engineering Research Center of MPTES in High Energy and Safety LIBs Engineering Research Center of MTEES (Ministry of Education) and Key Lab. of ETESPG(GHEI) South China Normal University Guangzhou 510006 P. R. China Key Laboratory of Functional Polymer Materials of Ministry of Education Institute of Polymer Chemistry College of Chemistry Nankai University Tianjin 300071 P. R. China College of Light Industry Science and Engineering, Tianjin University of Science and Technology, 300222 Tianjin, China Department of Chemical Engineering, University of Texas at Austin, Austin, TX, USA.; Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, TX, USA. Department of Urology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China College of Animal Science and Technology, Gansu Agricultural University, Lanzhou, Gansu, China Department of Obstetrics, Hebei General Hospital, Shijiazhuna 050055, China Advanced Water Management Centre, The University of Queensland, St. Lucia, Brisbane, Queensland 4072, Australia Herbivorous Livestock Institute, Chongqing Academy of Animal Sciences, Chongqing, People's Republic of China Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai, China Huaxi MR Research Center, Department of Radiology, Functional and Molecular Imaging Key Laboratory of Sichuan Province, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu 610041, China Department of Cardiology, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China Laboratory for Conservation and Utilization of Bio-resources, Key Laboratory for Microbial Resources of the Ministry of Education, Yunnan University, Kunming, PR China Fudan University Shanghai Cancer Center, Department of Oncology; and Institutes of Biomedical Sciences and School of Basic Medical Sciences, Shanghai Medical College of Fudan University, Shanghai 200032, China; State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai 200433, China Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129 Department of Orthopedics, Xuzhou Central Hospital, The Xuzhou Clinical School of Xuzhou Medical University, The Xuzhou School of Clinical Medicine of Nanjing Medical University, Xuzhou, China. Department of Respiratory, Zhuji Central Hospital of Zhejiang Province, Shaoxing 311800, PR China Key Laboratory of Molecular Precision Medicine of Hunan Province and Center for Medical Genetics Institute of Molecular Precision Medicine Xiangya Hospital Central South University Changsha China; Department of Neurology Xiangya Hospital Central South University Changsha China Center for Joining and Electronic Packaging, State Key Laboratory of Material Processing and Die & Mold Technology, School of Materials Science and Engineering, Huazhong University of Science and Technology, Wuhan 430074, P.R. China Huaxi MR Research Center Department of Nuclear Medicine Frontiers Science Center for Disease-related Molecular Network National Clinical Research Center for Geriatrics West China Hospital Sichuan University Chengdu 610041 China Departments of Medicine Department of Cell Biology and Physiology (J.L.), University of Pittsburgh, Pittsburgh, Pennsylvania 15261; Department of Ophthalmology, Sichuan Academy of Medical Sciences and Sichuan Provincial People’s Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China Electrical and Electronic Teaching Center, Electronics Information Engineering College, Changchun University, Changchun 130022, China School of Optoelectronic Science and Engineering & Collaborative Innovation Center of Suzhou Nano Science and Technology Soochow University Suzhou 215006 China Health Management Center, The Second Affiliated Hospital of Hainan Medical University Haikou 570311, Hainan, China. Department of Pharmacy Shanghai Jiao Tong University Affiliated Sixth People's Hospital Shanghai China Department of Gynaecology and Obstetrics, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, Jiangsu 210008, P.R. China Business School, Xi’an Fanyi University, Changan District Taiyi Palace, Xi’an, Shannxi Province, China Department of Reproductive Medicine, The Reproductive Hospital of Guangxi Zhuang Autonomous Region , Nanning, Guangxi Zhuang Autonomous Region , P.R. China State Key Laboratory of Chemo/Biosensing and Chemometrics, Advanced Catalytic Engineering Research Center of the Ministry of Education, College of Chemistry and Chemical Engineering, Hunan University, Changsha, Hunan 410082, PR China Xijing Hospital Air Force Medical University Xi'an China Beijing Key Laboratory of Photoelectronic/Electrophotonic Conversion Materials, Key Laboratory of Cluster Science, Ministry of Education, Advanced Technology Research Institute (Jinan), Frontiers Science Center for High Energy Material, School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing 100081, P. R. China Department of Orthopaedics, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou City, Guangdong Province, China National Key Discipline, Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, 150081 Harbin, China Key Laboratory of Analytical Chemistry for Life Science of Shaanxi Province, School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi'an, 710062, P.R. China Tianjin Key Laboratory of Molecular Optoelectronic Sciences Department of Chemistry Institute of Molecular Aggregation Science Tianjin University Tianjin 300072 China; Haihe Laboratory of Sustainable Chemical Transformations Tianjin 300192 China Key Laboratory of Organic Optoelectronics and Molecular Engineering, Department of Chemistry, Tsinghua University, Beijing 100084, China Key Laboratory of Bioinorganic and Synthetic Chemistry of Ministry of Education, School of Chemistry, Sun Yat-Sen University, Guangzhou, 510275, P. R. China The Fourth Department of Thyroid and Breast Surgery, Cangzhou Central Hospital, Cangzhou, Hebei 061000, P.R. China Obstetrics and Gynecology Department, Tianjin Medical University General Hospital, Tianjin China Beijing Key Laboratory of DNA Damage Response and College of Life Science, Capital Normal University, Beijing, China School of Physical Science and Technology, ShanghaiTech University, Shanghai 201210, China Hubei Key Laboratory of Agricultural Bioinformatics, College of Informatics, Huazhong Agricultural University , Wuhan 430070, China Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA Vascular Surgery Division, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China. Department of Neurology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China Shijiazhuang Information Engineering Vocational College 3 , ShiJiazhuang, Hebei 050000, China Cardiovascular Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892; Department of Toxicology, Henan Institute of Occupational Medicine, Zhengzhou, China Department of Intervention Affiliated Hospital of Jiangnan University, The Fourth People’s Hospital of Wuxi City, Jiangsu Province, China Interdisciplinary Center of Quantum Information, Zhejiang Province Key Laboratory of Quantum Technology and Device, and State Key Laboratory of Modern Optical Instrumentation, School of Physics, Zhejiang University , Hangzhou 310027 , China College of Acumoxibustion and Massage, Shaanxi University of Chinese Medicine, Xianyang 712046, China; Shaanxi Key Laboratory of Acupuncture and Medicine, Xianyang 712046, China Department of Dermatology and Cutaneous Surgery University of Miami Miller School of Medicine Miami FL, USA College of Science, Honghe University, Mengzi, 661199, Yunnan, China Department of Emergency, Xiangya Hospital, Central South University, Changsha, Hunan, 410008 PR China. State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China Department of Intensive Care Unit, Zhangjiagang TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou, Jiangsu 215600, P.R. China Key Laboratory of Molecular Nanostructure and Nanotechnology Institute of Chemistry Chinese Academy of Sciences and Beijing National Laboratory for Molecular Sciences Beijing 100190 China School of Life Science and Technology University of Electronic Science and Technology of China Chengdu China Shaanxi Yanchang Petroleum Fengyuan Co., Ltd., Yan’an 716000, China School of Materials Science and Chemical Engineering, Ningbo University, Ningbo, 315211, China Department of Gynecology and Obstetrics Tianjin Medical University General Hospital Tianjin PR China Dialysis Department of Nephrology Hospital, the First Affiliated Hospital of Xi’an Jiaotong University, Xi’an , Shaanxi, China Department of Oral and Maxillofacial Surgery, The Sixth Affiliated Hospital of Sun Yat‑sen University, Guangzhou, Guangdong 510655, P.R. China School of Chemistry & Materials Science, Jiangsu Normal University, Xuzhou 221116, P. R. China State Key Laboratory of Coal Combustion, Huazhong University of Science and Technology, Wuhan 430074, China. University of Nijmegen, Toernooiveld Department of Animal Physiology , , 6525 ED Nijmegen, The Netherlands Key Laboratory of Drinking Water Science and Technology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China National Engineering Laboratory for Oral Regenerative Medicine West China Hospital of Stomatology Sichuan University Chengdu 610041 China; Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences College of Stomatology Chongqing Medical University Chongqing 401147 China Department of Chemical and Biomolecular Engineering; University of California; Los Angeles; Los Angeles; USA Department of Pathology The First Affiliated Hospital of Xi’an Jiaotong University Xi’an, Shaanxi China Department of Dermatology, The Second Affiliated Hospital of Henan University of Science and Technology, Luoyang, Henan Province, China 4Global Health Research Center, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China; 5Department of Epidemiology and Center for Global Cardiometabolic Health, School of Public Health, Brown University, Providence, RI Department of Oncology The First Affiliated Hospital of Chongqing Medical University Chongqing China; Department of Oncology Jinshan Hospital of The First Affiliated Hospital of Chongqing Medical University Chongqing China; Chongqing Clinical Cancer Research Center Chongqing China Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China All authors are with Stanford University School of Medicine. Thomas J. Caruso, MD, MEd, is Clinical Associate Professor, Department of Anesthesiology, Perioperative, and Pain Medicine, and Faculty Advisor, Department of Graduate Medical Education; Tiffany Kung, BA, is a Medical Student; Nancy Piro, PhD, is Senior Program Specialist, Department of Graduate Medical Education; Jie Li, PhD, is Progra Institute of Molecular Precision Medicine, Xiangya Hospital and Center for Medical Genetics, Central South University, Changsha, Hunan, China 1 Division of Respiratory Care, Department of Cardiopulmonary Sciences, Rush University, Chicago, Illinois; and Department of Urology, the First Affiliated Hospital of Chongqing Medical University China ; Centre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, Barts and The London School of Medicine and Dentistry London UK. Department of Molecular Microbiology and Immunology, Keck School of Medicine School of Metallurgy and Environment Central South University Changsha 410083 PR China State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China Plant Phylogenetics and Conservation Group Center for Integrative Conservation Xishuangbanna Tropical Botanical Garden Chinese Academy of Sciences Kunming Yunnan China The Department of Psychiatry, Changzhou Dean Hospital, Changzhou City, 213000, Jiangsu Province, China Center for Obstetrics and Gynecology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University Nanjing China Center for Joining and Electronic Packaging; State Key Laboratory of Material Processing and Die & Mould Technology; School of Materials Science and Engineering; Huazhong University of Science and Technology; Wuhan 430074 College of Life Sciences, Northeast Agricultural University, No. 600 Changjiang Street Xiangfang District, Harbin 150030, China Department of Psychiatry Functional Neuroimaging Laboratory Tianjin Mental Health Center, Tianjin Anding Hospital Tianjin China State Key Laboratory of Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, China CDC 155, Changbai Road, Changping, Beijing, PR China Shanghai Institute for Advanced Immunochemical Studies ShanghaiTech University 201210 Shanghai China; School of Life Science and Technology ShanghaiTech University 201210 Shanghai China; Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences 200031 Shanghai China; University of Chinese Academy of Sciences 100049 Beijing China Department of Chest Surgery The General Hospital of The People's Liberation Army Beijing China; Department of Cardio‐thoracic Surgery First Affiliated Hospital General Hospital of PLA Beijing China Key Laboratory of Molecular Nanostructure and Nanotechnology, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China Key Laboratory for Organic Electronics and Information Displays & Institute of Advanced Materials (IAM) Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM) Nanjing University of Posts & Telecommunications Nanjing 210023 China MEET Battery Research Center; Institute of Physical Chemistry; University of Muenster; 48149 Muenster, Germany Department of Cardiology, First Affiliated Hospital of Shandong First Medical University, First Affiliated Hospital of Shandong First Medical University, Taian, Shandong, China Department of Metabolic Biology, John Innes Centre, Norwich NR4 7UH, United Kingdom Department of Thoracic Surgery, General Hospital of People's Liberation Army, Beijing 100853, China. lijie@301hospital.com.cn Breast Disease Center First Affiliated Hospital Sun Yat‐sen University Guangzhou Guangdong Province China Department of Infectious Diseases, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing, Jiangsu, China; Department of Infectious Diseases, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China; Institute of Viruses and Infectious Diseases, Nanjing University, Nanjing, Jiangsu, China; Department of Infectious Diseases, Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China Department of Infectious Disease, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325027, P.R. China Key Laboratory of Green-chemistry Materials in University of Yunnan Province, Key Laboratory of Advanced Synthetic Chemistry (Yunnan Minzu University) of State Ethnic Affairs Commission, School of Chemistry & Environment, Yunnan Minzu University, Kunming, 650500, P. R. China School of Computer Science and Technology; Harbin Institute of Technology; China College of Basic Medicine Chengde Medical University Chengde 067000 Hebei P. R. China. Electronics Information Engineering College, Changchun Univesity, Changchun 130022, China Contribution from the Motorola Clinical Micro Sensors, 757 South Raymond Avenue, Pasadena, California 91105, and Division of Biology and the Beckman Institute, California Institute of Technology, Pasadena, California 91125 Department of Neurology, Affiliated Yixing Peopleʼs Hospital of Jiangsu University, Peopleʼs Hospital of Yixing City, Yixing 214200, China School of Chemistry South China Normal University Guangzhou 51 0006 P. R. China MEET Battery Research Center & Institute of Physical Chemistry, University of Muenster, Corrensstr. 46&28/30, 48149 Muenster, Germany State Key Laboratory of Microbial Technology, School of Life Science, Shandong University , Jinan , China Department of Electrical and Computer Engineering University of Toronto 10 King's College Road Toronto Ontario M5S 3G4 Canada School of Chemistry and Biological Engineering University of Science and Technology Beijing Beijing China Department of Orthopedics, Zhujiang Hospital of Southern Medical University, Guangzhou, China The Third Affiliate Hospital of Southern Medical University (Academy of Orthopedics Guangdong Province), Guangzhou, Guangdong 510000, China Department of Medical Intensive Care Unit Maternal and Child Health Hospital of Hubei Province Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei 430070 China State Key Laboratory for Conservation and Utilization of Subtropical Agro‐bioresources Nanning China; Guangxi Key Laboratory of Animal Breeding Disease Control and Prevention Nanning China; College of Animal Science and Technology Guangxi University Nanning China The Department of Dermatology, Xiangya Hospital Central South University Changsha Hunan China; Hunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital Central South University Changsha Hunan China; Hunan Engineering Research Center of Skin Health and Disease, Xiangya Hospital Central South University Changsha Hunan China Division of Hepatobiliary and Pancreatic Surgery First Affiliated Hospital, Zhejiang University School of Medicine Hangzhou China; Key Laboratory of Combined Multi‐Organ Transplantation Ministry of Public Health China Department of Orthopaedics Xuzhou Central Hospital, Xuzhou Clinical College of Nanjing Medical University, The Affiliated Xuzhou Hospital of Southeast University Xuzhou Jiangsu China Department of Obstetrics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China; International Collaborative Laboratory of Reproduction and Development, Ministry of Education, Chongqing Medical University, Chongqing, China; State Key Laboratory of Maternal and Fetal Medicine of Chongqing Municipality, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China Department of Thoracic Surgery, West China Hospital, Sichuan University, 37 Guoxue Alley, Chengdu 610041, China; West China School of Nursing, Sichuan University, 37 Guoxue Alley, Chengdu 610041, China Charles H. Dyson School of Applied Economics and Management, Cornell S.C. Johnson College of Business Cornell University Ithaca New York USA State Key Laboratory of Medicinal Chemical Biology and Nankai University College of Pharmacy, and Tianjin Key Laboratory of Molecular Drug Research, Tianjin 300071, China College of Life Science, Capital Normal University, 100048 Beijing, China. *Department of Surgery, Reproductive Medical Center, Reproductive Medical Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China; State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences , Beijing , PR China 1 The State Key Laboratory of Pharmaceutical Biotechnology and Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, NJU Advanced Institute for Life Sciences (NAILS), School of Life Science, Nanjing University, Nanjing 210093, China; 2 Department of Bioinformatics, Medical School, George August University of Göttingen, Goldschmidtstrasse 1, Göttingen D-37077, Germany Department of Pathology General Hospital of Chinese PLA Beijing China Department of Urology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China China Agricultural University College of Plant Protection, , Haidian District, Beijing, 100083, China College of Water Sciences, Beijing Normal University, Beijing 100875, China; National Engineering Laboratory for Lake Pollution Control and Ecological Restoration, Chinese Research Academy of Environmental Sciences, Beijing 100012, China Center for AIE Research, College of Materials Science and Engineering, Shenzhen University, Shenzhen 518060, China; Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Optoelectronic Engineering, Shenzhen University, Shenzhen 518061, P. R. China; Beijing National Laboratory for Molecular Sciences (BNLMS), College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China School of Pharmacy Shanxi Medical University Taiyuan China Section of Applied Psychology Beijing Sport University China State Key Laboratory of Animal Nutrition, China Agricultural University, Beijing 100193, China Department of Gynecology, Women’s Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, Jiangsu, China (mainland) School of Clinical Medice, Fujian Medical University, Fuzhou 350108, China. Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-1414, USA Reconstructive Pelvic Surgery, Departments of Obstetrics and Gynecology, the Third Affiliated Hospital of Zhengzhou University College of Mechanical Engineering, Wuhan Polytechnic University, Wuhan 430048, China Department of Clinical Laboratory, The First Affiliated Hospital of Anhui Medical University, Hefei, People's Republic of China. Department of Chemical and Biomolecular Engineering, University of California at Los Angeles, Los Angeles, California 90095, United States Oncology Department, Beijing Chest Hospital of Capital Medical University, Beijing, China. College of Chemical and Material Engineering Quzhou University Quzhou 324000 P. R. China Department of Hematology, Children’s Hospital of Soochow University, Suzhou, China; Jiangsu Children’s Hematology & Oncology Center, Suzhou, China; Di Yao is also affiliated to Department of Pediatrics, Hangzhou First People’s Hospital, Hangzhou, China College of Stomatology, Chongqing Medical University; Chongqing Key Laboratory for Oral Diseases and Biomedical Sciences; Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing 401147, P.R. China University of Pittsburgh, Pittsburgh, PA, USA State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing, People's Republic of China Department of Earth and Environmental Sciences, University of Michigan, Ann Arbor, Michigan 48109, United States Beijing National Laboratory for Molecular Sciences, Key Laboratory of Molecular Nanostructure and Nanotechnology, CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.; University of Chinese Academy of Sciences, Beijing 100049, China. Tianjin Mental Health Institute Tianjin Anding Hospital Tianjin China Department of Infectious Diseases, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, Jiangsu, China; 2Department of Gastrointestinal Oncology, Key laboratory of carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital & Institute, Beijing, China. Hubei Insect Resources Utilization and Sustainable Pest Management Key Laboratory College of Plant Science and Technology Huazhong Agricultural University Wuhan 430070 Department of Obstetrics and Gynecology First Affiliated Hospital of Sun Yat‐Sen University Guangzhou China College of Animal Sciences, Zhejiang University, 310058 Hangzhou China; The Key Laboratory of Molecular Animal Nutrition, Ministry of Education, 310058 Hangzhou, China; Key Laboratory of Animal Feed and Nutrition of Zhejiang Province, 310058 Hangzhou, China 5Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas. Pearl River Fisheries Research Institute Chinese Academy of Fishery Sciences Guangzhou China; Scientific Observing and Experimental Station of Fishery Resources and Environment in Middle and Lower Reaches of Pearl River Ministry of Agriculture and Rural Affairs Guangzhou China Department of Radiology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China Key Laboratory of Cluster Science Ministry of Education, Beijing Key Laboratory of Photoelectronic/Electrophotonic Conversion Materials, School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing 100081, P.R. China Cyrus Tang Hematology Center, Jiangsu Institute of Hematology, First Affiliated Hospital, Soochow University, Suzhou, China; Huaxi MR Research Center, Department of Radiology, Functional and Molecular Imaging Key Laboratory of Sichuan Province, Frontiers Science Center for Disease Related Molecular Network, West China Hospital of Sichuan University, Chengdu, 610041, China Department of Neurology, Chinese PLA General Hospital, Beijing, PR China; Department of Pathology, Yale University School of Medicine, New Haven, CT, USA Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Key Laboratory of Otolaryngology Head and Neck Surgery, Beijing 100730, China. Department of Oncology, Cancer Center, Xin Hua Hospital, Shanghai Second Medical University, Shanghai 200092, China. ljee@citiz.net Department of Pediatrics, Anhui Provincial Hospital Affiliated to Medical University, Hefei, Anhui 230001, China. panjiahua1960@163.com. College of Optoelectronic Engineering, Chengdu University of Information Technology, Chengdu 610225, China State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X) and Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou 215123, China Institutes of Biology and Medical Sciences, Soochow University, Suzhou, China Shanghai Institute of Phage, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People’s Republic of China Institut für Organische und Biomolekulare Chemie, Georg-August-Universität, Tammannstrasse 2, 37077 Göttingen, Germany US Food and Drug Administration Silver Spring Maryland USA State Key Laboratory of Biomembrane and Membrane Biotechnology and Peking‐Tsinghua Center for Life Sciences and PKU‐IDG/McGovern Institute for Brain Research Institute of Molecular Medicine Peking University Beijing China Graduate School, Wuhan Sports University, Wuhan, China Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing, China Department of Orthopaedics Xinqiao Hospital, Amy Medical University (Third Military Medical University) Chongqing China School of Metallurgy and Environment, Central South University, Changsha 410083, P. R. China Department of Ultrasonography,the Affiliated Hospital of North China University of Science and Technology,Tangshan,Hebei 063000,China. Department of Epidemiology and Biostatistics Anhui Medical University Hefei China Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China;; Department of Bioinformatics, Nanjing Medical University, Nanjing, China; Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, National Animal Transmissible Spongiform Encephalopathy Laboratory, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China Research Center of Sustainable Development in the Yellow River Delta, Dongying 257000, Shandong, China. State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China; Nano Science and Technology Institute, University of Science and Technology of China, Suzhou, China Department of Endocrinology, Nanjing General Hospital of Nanjing Military Region, Nanjing, Jiangsu 210002, China. Department of Anesthesiology The Affiliated Hospital of Southwest Medical University Luzhou China National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China;; College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China; Department of Endocrinology, the affiliated Jinling Hospital of Nanjing Medical University, Nanjing, Jiangsu, China Department of Cardiology The First Affiliated Hospital Sun Yat‐Sen University, Key Laboratory on Assisted Circulation, Ministry of Health Guangzhou P.R. China Glycobiology and Glycochemistry Laboratory, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China School of Life Sciences and Technology, Tongji University, Shanghai, China Sweet Inn (Guangzhou) Technology Development Co., Ltd, Guangzhou, Guangdong, 510075, China Department of Earth and Environmental Sciences, University of Michigan, Ann Arbor, MI 48109; Department of Gastrointestinal Oncology Key laboratory of Carcinogenesis and Translational Research (Ministry of Education) Peking University Cancer Hospital & Institute Beijing China Jiangnan University-Lidu Liquor Industry (Yuan Dynasty) Ancient Cellar Microbial Joint Research and Development Center, Jiangxi Lidu Liquor Industry Co., Ltd., Nanchang, Jiangxi 331725, China Ministry of Education Key Laboratory of Interface Science and Engineering in Advanced Materials; Research Center of Advanced Materials Science and Technology; Taiyuan University of Technology; Taiyuan 030024; China Department of Pathology The First Affiliated Hospital of Xi'an Jiaotong University Xi'an 710061 Shaanxi China College of Science, Hebei Agricultural University, Baoding 071001, Hebei, China; College of Food Science and Technology, Hebei Agricultural University, Baoding 071001, China College of Environmental Science and Engineering; North China Electric Power University; Beijing; P. R. China; School of Resources and Environment Dialysis Department of Nephrology Hospital The First Affiliated Hospital of Xi'an Jiaotong University Xi'an Shaanxi China Department of Breast and Thyroid Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, P.R. China Beijing Institute of Respiratory Medicine, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China. Department of Laboratory Medicine , Peking University Shenzhen Hospital , Shenzhen, Guangdong , P.R. China Department of Respiratory and Critical Care Medicine Beijing Chao‐Yang Hospital Beijing Institute of Respiratory Medicine Capital Medical University Beijing China Division of Laboratory Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, PR China; Laboratory of Emerging Infectious Diseases, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, PR China Department of Urology The First Affiliated Hospital of Nanjing Medical University Nanjing China From the Departments of Neurological Surgery (Y.D., J.L., F.G.D.), Anatomy and Cell Biology (J.A.R.), and Physiology (J.W.P.), Wayne State University School of Medicine, Detroit, Mich. Stroke Center and Department of Neurology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei Anhui, 230001, China (C.T., Y.Y., J.L., R.L., P.X., J.Sun, W.H.). Division of Spine Surgery, Department of Orthopedic Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, China Department of Neurology and Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University , Suzhou , China CAS Center for Excellence in Nanoscience CAS Key Laboratory of Nanosystem and Hierarchical Fabrication National Center for Nanoscience and Technology Beijing 100190 P. R. China; University of Chinese Academy of Sciences Beijing 100049 P. R. China Institute of Molecular and Cell Biology, Singapore, Singapore Department of Hematology Nanfang Hospital Southern Medical University Guangzhou China Department of Dermatology Xiangya Hospital Central South University Changsha Hunan China; Furong Laboratory Changsha Hunan China; Hunan Key Laboratory of Skin Cancer and Psoriasis Changsha Hunan China; National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology Changsha Hunan China; National Clinical Research Center for Geriatric Disorders Xiangya Hospital Central South University Changsha Hunan China Key Laboratory for Liquid-Solid Structural Evolution and Processing of Materials; Ministry of Education; Shandong University; Jinan 250061; People's Republic of China Changhai Hospital The Second Military Medical University Shanghai China Cancer Centre and Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, Macau SAR 999078, China; MoE Frontiers Science Center for Precision Oncology, University of Macau, Macau SAR 999078, China Department of Burns and Cutaneous Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, 710032, China Rutgers, The State University of New Jersey, New Brunswick, NJ, USA State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, People’s Republic of China Beijing National Laboratory for Molecular Sciences Key Laboratory of Molecular Nanostructure and Nanotechnology Institute of Chemistry Chinese Academy of Sciences Beijing 100190 China Shanxi Academy of Chinese Medicine Taiyuan 030012, China. School of Electrical Engineering, Dalian University of Technology, Dalian, People’s Republic of China; Key Laboratory of Industrial Ecology and Environmental Engineering (Ministry of Education, China), School of Environmental Science and Technology, Dalian University of Technology, Dalian, People’s Republic of China State Key Laboratory of Applied Organic Chemistry and College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China. New York Blood Center, New York, NY CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, China Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Zhengzhou University, No. 1, East Jian She Road, Zhengzhou, Henan Province 450052, China Department of Epidemiology and Health statistics, School of Public Health Anhui Medical University Hefei Anhui China Northwest University Department of Acupuncture, First Clinical College of Harbin Medical University, Harbin 150001, China. hydyylj@163.com Yunnan University of Traditional Chinese Medicine, College of Traditional Chinese Medicine, Yuhua Road Kunming, China 650500; Institute of Medicine Plants, Yunnan Academy of Agricultural Sciences, Beijing Road, Kunming, China 650200 Department of Respiratory and Critical Care Medicine, the First Affiliated Hospital of Soochow University, Suzhou 215006, China. Department of Obstetrics and Gynecology The Affiliated Drum Tower Hospital of Nanjing University Medical School Nanjing China Department of Hepatobiliary Surgery ZhongShan hospital Xiamen University Fujian China; Fujian Provincial Key Laboratory of Chronic Liver Disease and Hepatocellular Carcinoma (Xiamen University Affiliated Zhongshan Hospital) Fujian China Department of Orthopedics, Lihuili Hospital Affiliated to Ningbo University, Ningbo, Zhejiang 315211, P.R. China Division of Gastroenterology‐HepatologyDepartment of Internal MedicineUniversity of IowaIowa City Iowa 52242 USA Hunan University of Chinese Medicine, Changsha, Hunan, China; Department of Ophthalmology, The First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, Hunan, China; School of Ophthalmology and Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China Geophysical Laboratory and Center for High Pressure Research, Carnegie Institution of Washington, Washington, DC 20015; and Department of Geophysical Sciences, James Franck Institute, and Consortium for Advanced Radiation Sources, University of Chicago, Chicago, IL 60637 Department of Thoracic Surgery HwaMei Hospital, University of Chinese Academy of Sciences Ningbo China Center for AIE Research; College of Materials Science and Engineering; Shenzhen University; Shenzhen 518060; China Institute of Electrostatics and Special Power, Dalian University of Technology, Dalian 116024, People’s Republic of China; Key Laboratory of Industrial Ecology and Environmental Engineering, Ministry of Education of the People’s Republic of China, Dalian 116024, People’s Republic of China Department of Medical Affairs, Fourth Hospital of Hebei Medical University, Shijiazhuang, China. Institute for Prevention and Control of STD and AIDS, Henan Provincial Center for Diseases Control and Prevention, Zhengzhou 450016, China. Department of Gastroenterology, Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu 214062, China Department of Obstetrics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China;; The Joint International Research Laboratory of Reproduction & Development, Ministry of Education, Chongqing Medical University, Chongqing, China;; State Key Laboratory of Maternal and Fetal Medicine of Chongqing Municipality, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China; School of Chemical and Environmental Engineering, China University of Mining & Technology (Beijing), Ding No.11 Xueyuan Road, Haidian District, Beijing 100083, China Vascular Biology Center, Medical College of Georgia, Augusta University, Augusta, GA 30912; Department of Dermatology Xiangya Hospital Central South University Changsha China; Hunan Key Laboratory of Skin Cancer and Psoriasis Xiangya Hospital Central South University Changsha Hunan China; Hunan Engineering Research Center of Skin Health and Disease Changsha Hunan China Australian Centre for Water and Environmental Biotechnology, The University of Queensland, St Lucia, Queensland 4072, Australia Department of Materials Science and Engineering; Inner Mongolia University of Technology; Huhhot 010051; China Gansu University of Chinese Medicine, Lanzhou 730000, China Institute for Advanced Study, Chengdu University, Chengdu 610106, China School of Metallurgy and Environment Central South University. No.932 Lushan Road Changsha city, Hunan Province 410083 P. R. China Beijing National Laboratory for Molecular Sciences, Key Laboratory of Molecular Nanostructure and Nanotechnology, CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China; University of Chinese Academy of Sciences, Beijing 100049, China CAS Center for Excellence in Nanoscience, CAS Key Laboratory of Nanosystem and Hierarchical Fabrication, National Center for Nanoscience and Technology, Beijing 100190, P. R. China Mudanjiang Medical University, Mudanjiang, Heilongjiang, PR China School of Metallurgy and Environment Central South University, Changsha Hunan 410083 P. R. China Department of Obstetrics and Gynecology, Tangshan Gongren Hospital, Tangshan, China State Key Laboratory of Phytochemistry and Plant Resources in West China and Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China; University of the Chinese Academy of Sciences, Beijing 100049, China School of Life Sciences, Tsinghua University, Beijing, China Department Beijing Key Laboratory of Photoelectronic/Electrophotonic Conversion Materials Key Laboratory of Cluster Science Ministry of Education School of Chemistry and Chemical Engineering Beijing Institute of Technology Beijing 100081 P. R. China State Key Laboratory of Oral Diseases West China Hospital of Stomatology Sichuan University Chengdu China; National Clinical Research Center for Oral Diseases West China Hospital of Stomatology Sichuan University Chengdu China; National Engineering Laboratory for Oral Regenerative Medicine West China Hospital of Stomatology Sichuan University Chengdu China School of Life Sciences, Tsinghua University, Beijing - PR China Beijing National Laboratory for Molecular Sciences, Laboratory of Molecular Nanostructure and Nanotechnology, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China; University of Chinese Academy of Sciences, Beijing 100049, China Pain Research Center, Department of Anesthesiology, University of Cincinnati Medical Center, Cincinnati, Ohio; College of Traditional Chinese Medicine Yunnan Univ. of Chinese Medicine Kunming China Beijing National Laboratory for Molecular Sciences; Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education; Synthetic and Functional Biomolecules Center; College of Chemistry and Molecular Engineering; Peking University Guangdong Meiweixian Flavoring Foods Co., Ltd Zhongshan China State Key Laboratory of Biocontrol; Guangdong Key Laboratory of Pharmaceutical Functional Genes; College of Life Sciences, Sun Yat-sen University; Guangzhou 510275 People's Republic of China The Key Laboratory for Microbial Resources of the Ministry of Education, PR China, and Laboratory for Conservation and Utilization of Bio-resources, Yunnan Institute of Microbiology, Yunnan University, Kunming, Yunnan 650091, PR China Department of Neonatology and NICU, Zaozhuang Maternal and Child Healthcare Hospital of Shandong Province, Zaozhuang 277100, China Department of Thoracic Surgery, General Hospital of The Chinese People's Liberation Army, Beijing 100853, P.R. China Laboratory of Molecular Sensory Science, Beijing Technology and Business University, No. 11, Fucheng Road, Haidian District, Beijing 100048, China Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of the Ministry of Education; College of Chemistry and Materials Science; Northwest University; Xi'an; P. R. China Nursing School; Shandong University; 44 Wenhuaxi Road Jinan Shandong Province 250012 China Department of Cardiology, Tianjin Hospital Tianjin 300211, China. School of Metallurgy and Environment, Central South University, Changsha 410083, Hunan, China; Engineering Research Centre of Advanced Battery Materials, The Ministry of Education, Changsha 410083, Hunan, China Dongying People's Hospital Dongying People's Republic of China Center for Cognition and Brain Disorders, The Affiliated Hospital, Hangzhou Normal University, Hangzhou, China. Cardiovascular Research InstituteSouth Dakota Health Research Foundation Sioux Falls South Dakota; Division of Basic Biomedical SciencesUniversity of South Dakota School of Medicine Sioux Falls South Dakota School of Chemistry and Chemical Engineering, Central South University, No. 932 Lushan South Road, Changsha 410083, China Department of Ophthalmology, University of Florida, Gainesville, FL 32610; Department of Geriatrics and Special Medical Treatment, The First Hospital of Jilin University, Changchun 130021, China Key Laboratory of Maricultural Organism Disease Control Ministry of Agriculture and Rural Affairs Yellow Sea Fisheries Research Institute Chinese Academy of Fishery Sciences Qingdao China Department of Otolaryngology-Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, No. 1 Dong Jiao Min Xiang Rd., Dong Cheng District, Beijing, China 100730. Department of Nephrology, Key Laboratory of Liver and Kidney Diseases of the Education Ministry of China, Shuguang Hospital Affiliated to Shanghai TCM University, Shanghai 201203, China. Department of Radiology and Huaxi MR Research Center (HMRRC) Functional and Molecular Imaging Key Laboratory of Sichuan Province and Frontiers Science Center for Disease Related Molecular Network West China Hospital Sichuan University Huaxi Research Building, 001 4th Keyuan Road 610041 Chengdu China School of Life Sciences; Fudan University; Shanghai 200438; China College of Pharmacy, Chengdu University of Traditional Chinese Medicine Chengdu 611137, China. Shanghai Diabetes Institute, Shanghai Jiaotong University No. 6 People’s Hospital, Shanghai, China School of Life Sciences and Health Engineering, Jiangnan University, Wuxi 214122, China Beijing National Laboratory for Molecular Sciences; Laboratory of Molecular Nanostructure and Nanotechnology; Institute of Chemistry; Chinese Academy of Sciences; Beijing 100190 College of Chemistry and Chemical Engineering, and Key Laboratory for Preparation and Application of Ordered Structural Materials of Guangdong Province Shantou University Shantou 515063 P. R. China Centre of Prenatal Diagnosis of Jiangsu Province, Drum Tower Hospital; Medical School of Nanjing University; Nanjing Jiangsu China Zhejiang Provincial Key Laboratory of Crop Genetic Resources, Institute of Crop Science, Zhejiang University, 310029 Zhejiang, China;; State Key Laboratory of Crop Genetics and Germplasm Enhancement, Nanjing Agricultural University, 210095 Nanjing, China; Innovation Experimental College Northwest A&F University Yangling Shaanxi 712100 China Cancer Center Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China Department of Chemical and Biomolecular Engineering; University of California, Los Angeles; Los Angeles; USA College of Chemistry and Chemical Engineering, Qingdao University, Qingdao, Shandong 266071, PR China Shanghai Institute for Advanced Immunochemical Studies ShanghaiTech University Shanghai 201210 China Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, California 92121, United States Beijing National Laboratory for Molecular Science, Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China; University of Chinese Academy of Sciences, Beijing 100190, China Department of Epidemiology, School of Public Health Brown University Providence Rhode Island USA; Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital Guangdong Academy of Medical Sciences Guangzhou China; Global Health Research Center, Guangdong Provincial People's Hospital Guangdong Academy of Medical Sciences Guangzhou China Department of Endocrinology, Chongqing Hospital of Traditional Chinese Medicine, Chongqing 400021, China. Department of Gynaecology and Obstetrics, The General Hospital of PLA, Beijing, China. Department of Chemistry and Biochemistry, and Department of Biology, Utah State University, 0300 Old Main Hill, Logan, Utah 84322-0300, and Infectious Disease Research Department, Southern Research Institute, 431 Aviation Way, Frederick, Maryland 21701 Department of Molecular and Cellular BiologyBaylor College of Medicine Houston Texas USA College of Animal Science and Technology, Northwest A&F University, Yanggling, China Department of Urology, The First Affiliated Hospital of Chongqing Medical University Chongqing, China. Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Eye Institute of Xiamen University; College of Medicine Xiamen University Xiamen Fujian Province China Department of Neurology, Zengcheng District People's Hospital of Guangzhou, Guangdong 511300, China Department of Emergency Surgery, Tianyou Hospital Affiliated to Wuhan University of Science & Technology, Wuhan, Hubei, China Department of General Surgery Second Affiliated Hospital School of Medicine Xi'an Jiaotong University Xi'an China Department of Plastic and Reconstructive Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China The State Key Laboratory of Dynamic Measurement Technology, The School of Instrument and Electronics, North University of China, Taiyuan 030051, China Department of Nutrition; Chinese People's Liberation Army General Hospital; Beijing; China School of Metallurgy and Environment, Central South University, Changsha 410083, China Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences , Guangzhou, China Department of Nutrition, Shanghai Children’s Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China Department of Hepatobiliary Surgery, The First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China Division of Spine Surgery, Department of Orthopedic Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China Department of Physiology; Anhui Medical University; Hefei Anhui China Department of Microbiology and Immunology, Oregon Health and Science University, Portland, Oregon The Second Affiliated Hospital, Guangzhou University of Chinese Medicine (Guangdong Provincial Hospital of Chinese Medicine), Guangzhou 510120 or 510006, PR China Shenyang Agricultural University Liaoning Key Laboratory of Strawberry Breeding and Cultivation, College of Horticulture, , 120 Dongling Road, Shenyang 110866, China School of Public Health Cheeloo College of Medicine Shandong University Jinan Shandong China Department of Urology, First Affiliated Hospital of Nanjing Medical University, Nanjing 210008, China Department of Pharmacology, Xi'an Jiaotong University College of Medicine, Xi'an, Shaanxi, P. R. China; Department of Pharmacology, Xiang-nan University, Chenzhou, Hu'nan, P. R. China Department of GeriatricsNational Key Clinic SpecialtyGuangzhou First People's HospitalSchool of MedicineSouth China University of Technology Guangzhou China; Department of Medicine Brigham and Women's Hospital and Harvard Medical School Boston MA USA State Key Laboratory of Membrane Biology and Beijing Key Laboratory of Cardiometabolic Molecular Medicine Institute of Molecular Medicine College of Future Technology Peking‐Tsinghua Center for Life Sciences, and PKU‐IDG/McGovern Institute for Brain Research Peking University Beijing 100871 China School of Naval Architecture, Ocean and Energy Power Engineering, Wuhan University of Technology, Wuhan, 430063, China Hospital of Stomatology, Sun Yat-sen University, Guangzhou, P.R. China; Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou, P.R. China; Guangdong Provincial Key Laboratory of Stomatology, Guangzhou, P.R. China Department of Histology and Embryology, Guizhou Medical University, Guiyang, Guizhou, China (mainland) Department of Pathology Chinese People's Liberation Army General Hospital Beijing China Department of Materials Science and Engineering, Southern University of Science and Technology, Shenzhen 518055, China Division of General Internal Medicine University of Pittsburgh Medical Center Pittsburgh Pennsylvania USA Division of Basic Biomedical Sciences and Cardiovascular Research Institute Sanford School of Medicine University of South Dakota Vermillion South Dakota USA Shangdong Engineering Research Center for Environment-Friendly Agricultural Pest Management, Qingdao Agricultural University, Qingdao 266109, China Key Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM) Nanjing Tech University (NanjingTech) Nanjing 211800 China Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu, China Department of Cell Biology and Genetics, Key Laboratory of Molecular Biology in High Cancer Incidence Coastal Chaoshan Area of Guangdong Higher Education Institutes, Shantou University Medical College, Shantou 515041, China Affiliated Brain Hospital of Guangzhou Medical University: Guangzhou Huiai Hospital School of Material Science and Engineering; University of Jinan; Jinan; China Shanghai Institute for Advanced Immunochemical Studies; ShanghaiTech University; Shanghai; China School of Chemistry and Chemical Engineering; Chongqing University; Chongqing 400044; China Beijing National Laboratory for Molecular Sciences Key Laboratory of Organic Solids Institute of Chemistry Chinese Academy of Sciences Beijing 100190 China; University of Chinese Academy of Sciences Beijing 100190 China Fudan University Shanghai Cancer Center, Institute of Biomedical Sciences, Shanghai Medical College of Fudan University, Shanghai 200032, P. R. China Department of Oncology, The Changhai Hospital, Shanghai 200433, P.R. China Department of Chemistry, Brandeis University, 415 South Street, Waltham, Massachusetts 02453, United States School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China Department of Dermatology and Cutaneous Surgery University of Miami, Miller School of Medicine Miami FL USA Department of Metabolic Biology, John Innes Centre Norwich Research Park Norwich UK Huazhong University of Science & Technology, China Department of Life Sciences, Hulunbuir University, Hulunbuir, Inner Mongolia Autonomous Region, China School of Pharmacy, Nantong University, Nantong, P.R. China School of Metallurgy and Environment, Central South University, Hunan Province Changsha 410083, China Department of Neurology, Jiangxi Provincial People’s Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, Jiangxi Province, China. Department of Psychology Renmin University of China Beijing China Department of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, China Key Laboratory of Marine Bio-resources Sustainable Utilization, CAS; RNAM Center for Marine Microbiology, CAS; Guangdong Key Laboratory of Marine Materia Medica; South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, 510301, PR China University of California at Davis Genome Center and Department of Applied Science, One Shields Avenue, Davis, California 95616, United States Department of Neurology, The First Affiliated Hospital of Chongqing Medical University Chongqing Key Laboratory of Neurology Chongqing 400016 China Department of Clinical Medical Laboratory, Peking University Shenzhen Hospital, Shenzhen, Guangdong Province, People’s Republic of China From the Departments of Medicine, Louisiana State University Health Sciences Center, Shreveport, LA. Key Laboratory of Medical Molecular Probes, School of Basic Medical Sciences Xinxiang Medical University Xinxiang Henan 453003 China Center for Genomic and Personalized Medicine, Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region - PR China; Department of Urology and Nephrology, First Affiliated Hospital of Guangxi Medical University, Nanning - PR China; Guangxi key laboratory for genomic and personalized medicine, Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region - PR China; Guangxi collaborative innovation center for genomic and personalized medicine, Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region - PR China Department of Marine Technology, Ocean University of China , Qingdao 266100, China LXL_ouc@163.com , ytytcj110@163.com , dzgao@ouc.edu.cn , jil004@ucsd.edu , wangyu@public.qd.sd.cn Key Laboratory of Marine Bio-resources Sustainable Utilization/Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, PR China; The Key Laboratory for Microbial Resources of the Ministry of Education, PR China and Laboratory for Conservation and Utilization of Bio-resources, Yunnan Institute of Microbiology, Yunnan University, Kunming, 650091, PR China Department of Radiotherapy Shanxi Cancer Hospital Taiyuan 030013 Shanxi P. R. China Department of Chinese Materia Medica and Natural Medicines, Air Force Medical University, Xi’an, 710032 Shaanxi, China Department of Infectious Diseases, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing, Jiangsu, China; Department of Infectious Diseases, Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China; Department of Infectious Diseases, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China Department of Hepatobiliary Surgery ZhongShan Hospital Xiamen University Fujian China; Fujian Provincial Key Laboratory of Chronic Liver Disease and Hepatocellular Carcinoma Xiamen University Affiliated Zhongshan Hospital Xiamen Fujian China Department of Respiratory Care, Rush University, Chicago, Illinois Yantai Nanshan Vocational Technology School, Yantai, China Department of Pediatric Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy of Tianjin, Tianjin’s Clinical Research Center for Cancer, Tianjin, China CAS Key Laboratory of Nanophotonic Materials and Devices & Key Laboratory of Nanodevices and Applications, i-Lab, Suzhou Institute of Nano-Tech and Nano-Bionics (SINANO), Chinese Academy of Sciences, Suzhou 215123, China School of Life Sciences, School of Chemistry & Chemical Engineering, Institute of Physical Science and Information Technology, Anhui University, Hefei, China Beijing National Laboratory for Molecular Sciences Key Laboratory of Organic Solids Institute of Chemistry Chinese Academy of Sciences Beijing 100190 China; University of Chinese Academy of Sciences Beijing 100049 China; Tianjin Key Laboratory of Molecular Optoelectronic Sciences Department of Chemistry School of Science Tianjin University & Collaborative Innovation Center of Chemical Science and Engineering Tianjin 300072 China Department of Mental Rehabilitation, The Affiliated Wuxi Mental Health Center with Nanjing Medical University, Wuxi Tongren Rehabilitation Hospital, Wuxi, Jiangsu 214151, China Department of Orthopedics, Ningbo Medical Center Lihuili Hospital, Ningbo 315040, China Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research, the Fifth Affiliated Hospital of Wenzhou Medical University /Affiliated Lishui Hospital of Zhejiang University/ The Central Hospital of Zhejiang Lishui, Lishui 323000, China; Department of Radiology, the Fifth Affiliated Hospital of Wenzhou Medical University /Affiliated Lishui Hospital of Zhejiang University/ The Central Hospital of Zhejiang Lishui, Lishui 323000, China Department of Ultrasound, Qilu Hospital of Shandong University, Jinan, PR China School of Optoelectronic Science and Engineering & Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou 215006, China Department of Chemistry, Brandeis University, Waltham, MA, USA College of Physics Science and Technology, Yangzhou University, Yangzhou 225002, China School of Life Sciences IDG/McGovern Institute for Brain Research at Tsinghua, Tsinghua University Beijing China College of Life Sciences, Anhui Provincial Key Lab of the Conservation and Exploitation of Biological Resources, Anhui Normal University, WuHu, China Key Laboratory for Molecular Genetic Mechanisms and Intervention Research on High Altitude Disease of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, Shaanxi, China; Engineering Research Center of Tibetan Medicine Detection Technology, Ministry of Education, School of Medicine, Xizang Minzu University, Xianyang, Shaanxi, China School of Pharmaceutical Science Guangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China; National Laboratory of Safety Evaluation (Environmental Assessment) of Veterinary Drugs, South China Agricultural University, Guangzhou, China; National Risk Assessment Laboratory for Antimicrobial Resistance of Animal Original Bacteria, South China Agricultural University, Guangzhou, China Shanghai Key Laboratory of New Drug Design, School of Pharmacy East China University of Science and Technology Shanghai China Department of Hepatobiliary Surgery ZhongShan Hospital of Xiamen University Fujian China; Fujian Provincial Key Laboratory of Chronic Liver Disease and Hepatocellular Carcinoma ZhongShan Hospital of Xiamen University Fujian China Neurosurgery and Guangdong Provincial Center for Disease Control and Prevention, Institute for AIDS/HIV Prevention and Control, Guangzhou 510300, P.R. China. Department of Urology, Lishui Central Hospital, The Fifth Affiliated Hospital, Wenzhou Medical University, Lishui, 323000, Zhejiang, China Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China; Department of Infectious Disease, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China Southern Medical University Department of Nursing, Shenzhen Hospital, , Shenzhen 518101 , China; Southern Medical University School of Nursing, , Guangzhou 510515 , China School of Physical Science and Technology, Inner Mongolia University, Hohhot, 010021, China Hefei National Laboratory for Physical Sciences at the Microscale, CAS Key laboratory of Brain Function and Disease, Department of Biophysics and Neurobiology, University of Science and Technology of China, Hefei, PR China School of Basic Medical Sciences Peking University Health Science Center Department of Plastic Surgery, Nanfang Hospital of Southern Medical University, Guangzhou 510515, China. College of Stomatology Chongqing Medical University Chongqing China; Chongqing Key Laboratory for Oral Diseases and Biomedical Sciences Chongqing China; Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education Chongqing China Department of Vascular Surgery, The First Affiliated Hospital, Sun Yat-Sen University School of Chemistry and Chemical Engineering, Central South University, Changsha 410083, P. R. China Department of Pharmacy, Cangzhou Central Hospital, Cangzhou, People's Republic of China Key Laboratory of Xinjiang Phytomedicine Resource and Utilisation, Ministry of Education, School of Pharmaceutical Sciences, Shihezi University, Shihezi 832002, China Key Laboratory of Microbial Diversity in Southwest China, Ministry of Education and Laboratory for Conservation and Utilization of Bio-Resources, Yunnan Institute of Microbiology, Yunnan University, Kunming 650091, PR China; Key Laboratory of Marine Bio-Resources Sustainable Utilization, CAS, RNAM Center for Marine Microbiology, CAS, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, PR China National Key Laboratory for Electronic Technology, School of Instrument and Electronics, North University of China , Taiyuan 030051, People’s Republic of China Department of Hepatobiliary Surgery, Shandong Qianfoshan Hospital, Jinan, Shandong 250014, P.R. China Department of Preventive Medicine, Wannan Medical College, Wuhu 241002, China. Maternal and Child Health Hospital of Hubei Province Department of Medical Intensive Care Unit, , Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430070 , China Department of Clinical Medicine, Suzhou Vocational Health College, Suzhou, Jiangsu 215009, P.R. China Cancer Epidemiology Services, New Jersey Department of Health Trenton New Jersey Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Key Laboratory of Maternal-Fetal Medicine of Liaoning Province, Shenyang, Liaoning 110004, China. hawk.lv@163.com. Department of Gastroenterology Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan Hubei China Department of Immunology, Cancer Biology PhD Program, University of South Florida, Tampa, USA Department of Hepatobiliary Surgery, First Affiliated Hospital, Xi’an Jiaotong University, China School of Pharmaceutical Engineering and Life Science Changzhou University Changzhou Jiangsu P. R. China Department of Gastrointestinal Oncology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital & Institute, Beijing 100142, China Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California College of Ocean Food and Biological Engineering, Xiamen Key Laboratory of Marine Functional Food, Fujian Provincial Engineering Technology Research Center of Marine Functional Food Jimei University Xiamen People's Republic of China School of Pharmacy, Jiangxi Science and Technology Normal University, Nanchang, China Department of Dermatology Xiangya Hospital Central South University Changsha China; National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology Changsha China; Furong Laboratory Changsha China; Hunan Key Laboratory of Skin Cancer and Psoriasis Hunan Engineering Research Center of Skin Health and Disease Xiangya Hospital Central South University Changsha China; National Clinical Research Center for Geriatric Disorders (Xiangya Hospital) Changsha China Division of Gastroenterology, Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 39, Yanhu Avenue, Wuhan, Hubei, China College of First Clinical Medicine, Shandong University of Traditional Chinese Medicine Jinan Shandong P. R. China Department of Molecular Microbiology and Immunology, University of Southern California, Los Angeles, California 90033 Department of Neurology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science/Peking Union Medical College, Beijing 100730, China 6Cancer Epidemiology Services, New Jersey Department of Health, Trenton, New Jersey. University of Nijmegen Department of Animal Physiology , , Toernooiveld, 6525 ED Nijmegen, The Netherlands College of Stomatology Chongqing Medical University Chongqing China; Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences Chongqing China; Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education Chongqing China Department of Chemistry; Brandeis University; Waltham, USA Shanxi Medical University Affiliated Tumor Hospital, Shanxi Cancer Hospital, Taiyuan 030013, PR China Department of Medical Materials and Rehabilitation Engineering, School of Biological and Medical Engineering, Hefei University of Technology, Hefei, Anhui 230009, China School of Chemistry and Chemical Engineering, Central South University, Changsha 410083, Hunan, China College of Food Science and Engineering, Jilin University, Changchun 130062, China Cardiology Department, Guangdong Provincial People’s Hospital, Guangzhou, Guangdong, P. R. China Department of Ultrasound, Qilu Hospital of Shandong University, Jinan, Shandong, PR China Department of Neurology, Xinqiao Hospital, The Third Military Medical University, Chongqing, China Laboratory of Biological Psychiatry, Institute of Mental Health, Tianjin Anding Hospital Tianjin Medical University Tianjin China The Key Laboratory for Microbial Resources of the Ministry of Education and Laboratory for Conservation and Utilization of Bio-resources, Yunnan Institute of Microbiology, Yunnan University, Kunming, Yunnan, 650091, PR China Department of Internal Medicine, Division of Gastroenterology-Hepatology, University of Iowa College of Medicine, Iowa City, IA 52242 Affiliated Xiamen Eye Center and Eye Institute of Xiamen University, Xiamen, China School of Computer Science and Technology, Harbin Institute of Technology, Harbin 150001, China. Department of Hematology Hongqi Hospital Affiliated to Mudanjiang Medical University Mudanjiang China Department of Obstetrics and Gynecology, University of Arizona, Tucson, AZ, USA ; Department of Pathology, University of Arizona College of Medicine, Tucson, AZ, USA ; Department of Obstetrics and Gynecology, Qilu Hospital, Shandong University, Shandong, China. BGI Beishan Industrial Zone Guangdong China Department of Orthopedics, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province, China Institute of Pharmacy and Pharmacology, Key Laboratory for Arteriosclerology of Hunan Province University of South China Hengyang China Department of Chemistry & Biochemistry, University of Maryland, College Park, Maryland 20742, United States Xi’an Central Hospital, China State Key Laboratory of Plant Physiology and Biochemistry, College of Life Sciences, Zhejiang University , Hangzhou, Zhejiang 310058 , China Research Center of Laser Fusion, China Academy of Engineering Physics, Chengdu 610093, China School of Chemistry and Chemical Engineering; Yangzhou University; Yangzhou 225002; China Department of Neonatology Maternity and Child Health Care of Zaozhuang Zaozhuang China CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, Guangdong, China; Key Laboratory of Tropical Marine Biotechnology of Hainan Province, Sanya Institute of Oceanology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, Guangdong, China; Sanya National Marine Ecosystem Research Station, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, Guangdong, China 1Department of Biochemistry, Purdue University, West Lafayette, Indiana. Brain Glioma Center Zhongnan Hospital of Wuhan University Wuhan China; Department of Physiology Wuhan University School of Basic Medical Sciences Wuhan China UC Davis Genome Center and Department of Applied Science, University of California, Davis, One Shields Avenue, Davis, California 95616, United States Department of Chemistry Paderborn University Warburgerstraße 100 D‐33098 Paderborn Germany Department of Hand Surgery Huashan Hospital Fudan University Shanghai China Protein Science Laboratory of the Ministry of Education, School of Life Sciences, Tsinghua University, Beijing 100084, China; National Engineering Laboratory for Anti-Tumor Protein Therapeutics, School of Life Sciences, Tsinghua University, Beijing 100084, China Department of Environmental Science and Engineering, University of Science & Technology of China, Hefei 230026, China; USTC-CityU Joint Advanced Research Center, Suzhou Institute for Advance Resmuchearch of USTC, Suzhou, 215123, China Medical Records Room,PUMC Hospital,CAMS and PUMC,Beijing 100730,China. Department of Radiology and Vascular Surgery The 1st Affiliated Hospital of Sun Yat‐sen University Guangzhou China Jiangxi Province Key Laboratory of Preventive Medicine School of Public Health Nanchang University Nanchang P. R. China School of Computer Science and Engineering, Nanyang Technological University, 639798, Singapore College of First Clinical Medicine, Shandong University of Traditional Chinese Medicine Jinan Shandong China Ministry of Agriculture Key Lab of Molecular Biology of Crop Pathogens and Insects Institute of Insect Sciences, Zhejiang University Hangzhou China From the Department of Interventional Oncology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education) (X.W., J.H., G.C., X.Z., R.Y., H.C., H.X., P.L.), Departments of Radiology (Y.C.), Medical Statistics (X.J.), and GI Oncology (Jian Li, Jie Li, L.S.), and Department of Hepatic, Biliary & Pancreatic Surgery (C.H., B.X.), Peking University Cancer Hospital & Institute, 52 Fucheng Road, Haidian District, Beijing 100142, China; and Department of Mathematics and... Department of General Surgery, Shandong Provincial Qianfoshan Hospital Shandong University Jinan Shandong China; Department of General Surgery, Shandong Provincial Qianfoshan Hospital The First Hospital Affiliated with Shandong First Medical University Jinan Shandong China Department of Chemistry and Biochemistry, University of California, Santa Cruz, California 95064, and Institute for Biological Instrumentation, Russian Academy of Sciences, 142292 Pushchino, Moscow Region, Russia School of Life Sciences, Tsinghua University, 100084 Beijing, China;; Tsinghua-Peking Center for Life Sciences, Tsinghua University, 100084 Beijing, China; Genomics Institute of the Novartis Research Foundation, 10675 John J. Hopkins Drive, San Diego, California 92121, United States Center for Advanced Materials Research, Beijing Normal University, Zhuhai 519087, China Authors' Affiliations: Departments of 1Pathology, 2Thoracic/Head and Neck Medical Oncology, and 3Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, and 4Pediatrics, Baylor College of Medicine, Houston, Texas Biotechnology Research Institute, National Research Council Canada, 6100 Royalmount Avenue, Montreal, Quebec, Canada Beijing National Laboratory for Molecular Sciences, Key Laboratory of Molecular Nanostructure and Nanotechnology, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China Department of Anesthesiology, Shanghai Zhongshan Hospital, Shanghai, China; Department of Anesthesiology, Shanghai Zhongshan Hospital, Shanghai, China Rowan University College of Materials Science and Engineering, Taiyuan University of Technology, Taiyuan 030024, China. Jeffrey D. White, Libin Jia, and Roy S. Wu, National Cancer Institute, Rockville; Jinhui Dou, Food and Drug Administration, Silver Spring, MD; Hongsheng Lin and Jie Li, China Academy of Chinese Medical Sciences, Beijing; Lizhu Lin, First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou; Lixing Lao, The University of Hong Kong, Pokfulam, Hong Kong, Special Administrative Region, People’s Republic of China; Stephen Lam, British Columbia Cancer Agency, Vancouver, British Columbia,... Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI, USA. Institute of Molecular and Cell Biology, A*STAR (Agency for Science, Technology and Research), 61 Biopolis Drive, Proteos, Singapore 138648, Republic of Singapore. Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Gannan Medical University, Ganzhou 341000, China School of Metallurgy and Environment Central South University Changsha Hunan 410083 China University of Miami Miller School of Medicine, Department of Dermatology & Cutaneous Surgery, Miami, Florida, US State Key Laboratory of Chemical Resource Engineering; Beijing Laboratory of Biomedical Materials; Beijing University of Chemical Technology; 100029 Beijing; China School of Medicine; Zhejiang University City College; Hangzhou 310015; P. R. China The Second Affiliated Hospital of Hainan Medical University Health Management Center Haikou 570311, Hainan, China. From the Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA (X.Z., J.L., S.L., M.W., Q.H., Z.D., C.d.F., A.D., P.X.L., G.K.S., G.-P.S., J.G.); Department of Geriatrics, National Key Clinic Specialty, Guangzhou First People’s Hospital, School of Medicine, South China University of Technology, Guangzhou, China (J.L.) National Laboratory of Biomacromolecules Institute of Biophysics Chinese Academy of Sciences, CAS Center for Excellence in Biomacromolecules Beijing 100101 China *Department of Pediatrics, Department of Electronic and Electrical Engineering, Southern University of Science and Technology, No 1088, Xueyuan Rd., Xili, Nanshan District, Shenzhen 518055, Guangdong, P. R. China College of Veterinary Medicine, South China Agricultural University, Guangzhou, Guangdong, China Department of Clinical Medicine, The Third Clinical School, Guangzhou Medical University, Guangzhou, China. Pitzer Center for Theoretical Chemistry, Department of Chemistry, University of California, Berkeley, CA, USA. Department of Neurology The Second Affiliated Hospital, Harbin Medical University Harbin Heilongjiang Province China Department of Hepatobiliary and Pancreatic Surgery, Henan Key Laboratory of Digestive Organ transplantation, The First Affiliated Hospital of Zhengzhou University Zhengzhou University Zhengzhou China Department of Clinical Laboratory , Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences , Jinan , Shandong , P.R. China Department of Microbiology and Infectious Disease Center, School of Basic Medical Sciences Peking University Health Science Center Beijing China Department of General Surgery The First Affiliated Hospital of Nanjing Medical University Nanjing Jiangsu China School of Materials Engineering, Shanghai University of Engineering Science, Shanghai 201620, China Professor, Ren-Fu Pharmacy, Ltd., Yichang, Hubei, China. Beijing Center for Disease Prevention and Control, Beijing 100013, China. Department of Neurosurgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, China All authors: Department of Radiology, Breast Imaging Section, Memorial Sloan-Kettering Cancer Center, 1114 First Ave., Second Floor, New York, NY 10065. Department of Orthopaedics Xinqiao Hospital, Army Medical University Chongqing China Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China National Key Laboratory of Green Pesticide, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, State-Local Joint Laboratory for Comprehensive Utilization of Biomass, Center for R&D of Fine Chemicals, Guizhou University, Guiyang 550025, China Department of Hepatobiliary Surgery, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, China Department of Oncology, No. 900 Hospital of The Joint Logistic Support Force Fuzhou 350025, Fujian, China. Department of Laboratory Medicine, Huangyan Hospital, Wenzhou Medical University, Taizhou, Zhejiang Province, People’s Republic of China Key Laboratory of Superlight Materials and Surface Technology of the Ministry of Education and ‡Institute of Advanced Marine Materials, Harbin Engineering University, Harbin 150001, PR China Department of Physics and Astronomy, University of California , Irvine, CA , United States Genome Centre University of California Davis CA 95616 USA Centre for Neuroscience, Surgery and Trauma, Blizard Institute, Barts and the London School of Medicine and Dentistry Queen Mary University of London London UK Key Laboratory of Coarse Cereal Processing (Ministry of Agriculture and Rural Affairs), Sichuan Engineering & Technology Research Center of Coarse Cereal Industralization, School of Food and Biological Engineering, Chengdu University, Chengdu 610106, China; Institute for Advanced Study, Chengdu University, Chengdu 610106, China Division of Gastroenterology-Hepatology, Department of Internal MedicineUniversity of IowaIowa CityIowa 52242USA Department of Thoracic Surgery, General Hospital of PLA Beijing 100853, China. State Key Laboratory of Chemical Oncogenomics Peking University Shenzhen Graduate School, Xili Nanshan District Shenzhen 518055 China College of Plant Health and Medicine, Shandong Engineering Research Center for Environment-Friendly Agricultural Pest Management, Qingdao Agricultural University, Qingdao, Shandong 266109, China Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China. Key Laboratory of Novel Thin Film Solar Cells, Institute of Plasma Physics, Chinese Academy of Sciences, P.O. Box 1126, Hefei 230031, P. R. China State Key Laboratory for Mechanical Behaviour of Materials, Xi’an Jiaotong University, 710049 Xi’an, China; Laboratory of Nuclear Energy Chemistry, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, P. R. China College of Water Conservancy and Civil Engineering, Shandong Agricultural University, Tai'an, Shandong 271018, China Department of Neurology, Weihai Municipal Hospital, The Affiliated Hospital of Binzhou Medical University, Weihai, China the First Affiliated Hospital of University of Science and Technology of China (Anhui Provincial Hospital) Hefei 230001, China. Institute for Advanced Ceramics, State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, Harbin 150001, P. R. China School of Engineering RMIT University Melbourne Vic. 3001 Australia The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310003, PR China State Key Laboratory of Quality Research in Chinese Medicines, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Taipa, Macau SAR 999078, China Department of Immunology and Cell Biology, College of Veterinary Medicine, Agricultural University of Hebei, Baoding 071000, China. lijie2006698@yahoo.com.cn Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio. Department of Neurosurgery, University of Minnesota, Minneapolis, MN 55455; Shanghai University of Traditional Chinese Medicine, Shanghai, China Department of Chemical and Biomolecular Engineering, National University of Singapore, Singapore 117585, Singapore Institute of Electrostatics and Special Power, Dalian University of Technology, Dalian 116024, China. ljshq@yahoo.com.cn Department of Neurology, Zengcheng District People’s Hospital of Guangzhou, Guangzhou, China Cancer Center Faculty of Health Sciences University of Macau Macau 999078 China; Center for Precision Medicine Research and Training Faculty of Health Sciences University of Macau Macau 999078 China Key Laboratory of Marine Bio-Resources Sustainable Utilization, CAS, RNAM Center for Marine Microbiology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, PR China Human Health Therapeutics, National Research Council Canada, 6100 Royalmount Avenue, Montreal, Québec H4P 2R2, Canada Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI 48109-1048 School of Mechanical Engineering, Shenyang Jianzhu University, No. 25 Middle Road Hunnan, Shenyang, 110168, China Department of Cardiology, Vascular Center, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital Guangdong Academy of Medical Sciences Guangdong People's Republic of China Pathology Institute of Medical Plant Physiology and Ecology, School of Pharmaceutical Sciences Guangzhou University of Chinese Medicine Guangzhou 510006 China Department of Gynaecology, He Bei General Hospital, Shijiazhuang, Hebei, China. lijie19821029@126.com. Hefei Institutes of Physical Science Chinese Academy of Sciences Hefei Anhui China; Hefei Cancer Hospital Chinese Academy of Sciences Hefei Anhui China Institutes of Psychological Sciences, Hangzhou Normal University, Hangzhou, China; lijie.psy@foxmail.com Department of Zhuang Medicine Acupuncture, The First Affiliated Hospital of Guangxi University of Chinese Medicine, Guangxi, China Department of Laboratory Medicine Peking University Shenzhen Hospital Shenzhen China Department of Basic Medical Sciences & Forensic Medicine, Hangzhou Medical College, Hangzhou 310059, China Department of Orthopedics, Xuzhou Central Hospital, Xuzhou Clinical School of Xuzhou Medical University, The Affiliated Xuzhou Hospital of Medical College of Southeast University, Xuzhou Clinical Medical College of Nanjing University of Chinese Medicine Xuzhou China Department of Hand and Upper Extremity Surgery, Jing’an District Center Hospital, Shanghai, China; Shanghai Clinical Medical Center for Limb Function Reconstruction, Shanghai, China Department of Laboratory Medicine, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China; the Department of Cell Biology and Physiology (J.L., D.W., A.Z.Z.), University of Pittsburgh, Pittsburgh, Pennsylvania 15261 Ruhr-University of Bochum 1 Junior Research Group Magnetic Microscopy, Institute for Experimental Physics IV, , Universitätsstr. 150, D-44780 Bochum, Germany Department of Ophthalmology, Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610072, Sichuan Province, China. University of Georgia Department of Genetics , , Athens, GA 30602 , USA Center for Theoretical and Applied Neuro-Oncology, University of California, San Diego, CA, USA Department of Gastrointestinal Oncology, Peking University Cancer Hospital, Beijing, China Department of Occupational and Environmental Health, School of Public Health, Capital Medical University, Beijing 100069, China; Beijing Key Laboratory of Environmental Toxicology, School of Public Health, Capital Medical University, Beijing 100069, China College of Life Sciences, Qingdao Agricultural University, Qingdao 266109, China. Department of Neurology The People's Hospital of Deyang City Deyang Sichuan China Department of Clinical Laboratory Peking University Shenzhen Hospital Shenzhen China Department of Infectious Diseases, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, Jiangsu 210008, China; Institute of Viruses and Infectious Diseases, Nanjing University, Nanjing, Jiangsu 210008, China Henan Key Laboratory of Polyoxometalate Chemistry, School of Chemistry and Chemical Engineering, Henan University, Kaifeng, Henan 475004, P. R. China; School of Chemistry & Chemical Engineering, Zhoukou Normal University, Zhoukou, Henan 466001, P. R. China Department of Orthopaedics, Xuzhou Central Hospital, Clinical School of Xuzhou Medical University, Xuzhou, Jiangsu 221009, China Department of Psychiatric Neuroimaging Laboratory, Tianjin Anding Hospital, Tianjin Mental Health Center, Teaching Hospital of Tianjin Medical University, Tianjin, China Department of Nuclear Medicine, West China Hospital, Sichuan University, Chengdu 610041, China Department of Cellular Biophysics Max Planck Institute for Medical Research Jahnstraße 29 69120 Heidelberg Germany; Department of Biophysical Chemistry Institute of Physical Chemistry University of Heidelberg Im Neuenheimer Feld 253 69120 Heidelberg Germany Department of Oncology, Second Affiliated Hospital of Xi’an Jiaotong University, Xi'an, China (mainland) Department of Neurology, Suzhou Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215004, China Department of Pharmacology, Xi’an Jiaotong University College of Medicine, Xi’an, Shaanxi 710061, China; Department of Pharmacy, The First People’s Hospital of Chenzhou, Institute of Translational Medicine, Nanhua University, Chenzhou, Hunan 423000, China The Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou, China Department of Infectious Diseases, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, Jiangsu, China; Institute of Viruses and Infectious Diseases, Nanjing University, Nanjing, Jiangsu, China State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China Center for Ecosystem Science and Society Northern Arizona University Flagstaff Arizona USA Department of Liver Surgery, Renji Hospital, School of Medicine Shanghai Jiao Tong University Shanghai China Department of Urology The First Affiliated Hospital of Nanjing Medical University and Jiangsu Province Hospital Nanjing China Department of Pharmacognosy, West China School of Pharmacy, Sichuan University, Chengdu, 610041, China National Engineering Laboratory for Cereal Fermentation Technology, Jiangnan University, Wuxi 214122, Jiangsu, China. School of Biotechnology, Jiangnan University, Wuxi 214122, Jiangsu, China. Department of Pharmacy, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, P.R. China Beijing National Laboratory for Molecular Sciences; Key Laboratory of Molecular Nanostructure and Nanotechnology; CAS Research/Education Center for Excellence in Molecular Sciences; Institute of Chemistry; Chinese Academy of Sciences State Key Laboratory of Material Processing and Die & Mould Technology; School of Materials Science and Engineering; Huazhong University of Science and Technology; Wuhan 430074; China Baikouquan Oil Production Plant of Petrochina Xinjiang Oilfield Branch, Karamay 834000, China Beijing National Research Center for Molecular Sciences, Key Laboratory of Molecular Nanostructure and Nanotechnology, Institute of Chemistry, Chinese Academy of Sciences , Beijing 100190 , China Biological psychiatry Laboratory, Tianjin Mental Health Institute, Tianjin Anding Hospital, Tianjin, China Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, 200032, China Department of Neurology and Suzhou Clinical Research Center of Neurological Disease The Second Affiliated Hospital of Soochow University Suzhou China; Sleep Center The Second Affiliated Hospital of Soochow University Suzhou China School of Metallurgy and Environment, Central South University, Changsha, Hunan 410083, China OFS Fitel LLC Cancer Epidemiology Services, New Jersey Department of Health, Trenton, NJ Department of thoracic Surgery, Chinese PLA General Hospital, Beijing, China Xiangya School of Medicine, Central South University, Changsha 410013, China. Henan Key Laboratory of Polyoxometalates, Institute of Molecular and Crystal Engineering, College of Chemistry and Chemical Engineering, Henan University, Kaifeng 475004, P. R. China; School of Chemistry & Chemical Engineering, Zhoukou Normal University, Zhoukou 466001, P. R. China SETI Institute, Mountain View, CA 94043, USA. Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, China; University of Chinese Academy of Sciences, Beijing 100049, China; Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), Guangzhou 511458, China; Sanya Institute of Oceanology, SCSIO, Yazhou Scientific Bay, Sanya 572000, China 1Cardiovascular Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, Maryland. Domestic Discovery Service Unit, WuXi AppTec (Shanghai) Co. Ltd., 288 FuteZhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131, China Jiangsu Textiles Quality Services Inspection Testing Institute, Nanjing 210007, People’s Republic of China Department of Environmental Health; School of Public Health; Shandong University; Jinan China Department of Neurology The Second Affiliated Hospital of Qiqihar Medical University Qiqihar China School of Metallurgy and Environment, Central South University, Changsha 410083, China; Engineering Research Center of Advanced Battery Materials, The Ministry of Education, Changsha 410083, China The Division of Thyroid and Parathyroid Endocrine Surgery, Massachusetts Eye and Ear Infirmary, Harvard Medical School Boston, MA 02114, USA. Department of Epidemiology, Brown University, Providence, RI; Department of Cardiology, Guangdong Cardiovascular Institute, Hypertension Research Laboratory, Guangdong Provincial People’s Hospital, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Academy of Medical Sciences, South China University of Technology School of Medicine, Guangzhou, China CAS Key Laboratory of Receptor Research, Synthetic Organic & Medicinal Chemistry Laboratory, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, People’s Republic of China; ShanghaiTech University, Shanghai 20120, People’s Republic of China Department of Endocrine and Breast Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, P.R. China Department of Emergency, Hubei Maternal and Child Health Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China 1Department of Surgery and The Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, Missouri and Center for Medical Genetics and School of Life Science Central South University Changsha China Center for Obstetrics and Gynecology Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University Nanjing China; Center for Obstetrics and Gynecology, Nanjing Drum Tower Hospital Nanjing University Medical School Nanjing China Key Laboratory of Radiopharmaceuticals; Ministry of Education; College of Chemistry; Beijing Normal University; Beijing 100875 School of Civil Engineering, Central South University, Changsha 410075, China; National Engineering Laboratory for High Speed Railway Construction, Central South University, Changsha 410075, China Department of Pediatrics, Stanford University School of Medicine, Stanford, California; Department of Gastrointestinal Oncology, Key laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Peking University Cancer Hospital and Institute, Beijing, China Pearl River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Guangzhou, China;; Experimental Station for Scientific Observation on Fishery Resources and Environment in the Middle and Lower Reaches of Pearl River, Ministry of Agriculture The People’s Republic of China, Guangzhou, China Department of Genetics, Paul D. Coverdell Center, University of Georgia, Athens, Georgia Department of Gastroenterology Department of Clinical Laboratory, First People’s Hospital of Tianshui, Gansu, China Division of Gastroenterology and Hepatology, Stanford University Medical Center, Palo Alto; Department of Infectious Disease, Shandong Provincial Hospital Affiliated to Shandong University, Ji’nan, Shandong, China Key Laboratory of Organic Optoelectronics and Molecular Engineering, Department of Chemistry, Tsinghua University, Beijing 100084, People’s Republic of China Department of Psychiatry, Tianjin Anding Hospital, Tianjin Mental Health Center, Tianjin, 300222, China State Key Laboratory of Biocatalysis and Enzyme Engineering, Hubei Engineering Research Center for Bio-enzyme Catalysis, Environmental Microbial Technology Center of Hubei Province, Hubei Collaborative Innovation Center for Green Transformation of Bio-resources, School of Life Sciences, Hubei University, Wuhan 430062, People's Republic of China Dermatology Hospital of Jiangxi Provinces and Jiangxi Dermatology Institute, Nanchang, China Shanghai Measure Testing Technology Academe Shanghai China Department of Neurology, The Second Affiliated Hospital of Soochow University, Suzhou 215004, China; Clinical Research Center for Neurological Diseases, Soochow University, Suzhou 215004, China Department of Chemistry Brandeis University 415 South St Waltham MA 02454 USA State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Bioactive Natural Product Research, School of Traditional Chinese Pharmacy China Pharmaceutical University Nanjing China Pearl River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Guangzhou 510380, China; Guangzhou Scientific Observing and Experimental Station of National Fisheries Resources and Environment, Guangzhou 510380, China; Key Laboratory of Aquatic Animal Immune Technology of Guangdong Province, Guangzhou 510380, China The First College of Clinical Medicine Nanjing Medical University Nanjing P.R. China; Department of Colorectal Surgery The First Affiliated Hospital of Nanjing Medical University Nanjing P.R. China Department of Nephrology, Zhuzhou Central Hospital, Zhuzhou, Hunan, China Department of Pulmonary and Critical Care Medicine, Beijing Anzhen Hospital, Capital Medical University, 2nd Anzhen Road, Chaoyang District, Beijing 100029, China Department of Neurology The Second Affiliated Hospital Harbin Medical University Harbin China Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, 500 West 12th Avenue, Columbus, Ohio 43210, United States |
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