author/MD5_49e6c0cec10d2f39f023e4a053b763e5

http://rdf.ncbi.nlm.nih.gov/pubchem/author/MD5_49e6c0cec10d2f39f023e4a053b763e5

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Predicate	Object
family-name	Yuan Yuan Yuan
name	Yuan Yuan
given-name	Yuan
organization-name	Department of Clinical Laboratory, the Affiliated Hospital of Qingdao University, Qingdao, China yuanyuan51307@163.com. College of Material Science and Engineering, Chongqing University, Chongqing 400044, China 4Cancer Institute of the First Affiliated Hospital, China Medical University, Heping District, Shenyang City, Liaoning, P.R. China Department of Applied Chemistry, School of Chemistry and Materials Science, Hefei National Research Center for Physical Sciences at the Microscale, University of Science and Technology of China, Hefei, Anhui230026, China Xuanwu Hospital, Capital Medical University, Beijing, China School of Pharmacy Xinxiang Medical University Xinxiang China; Xinxiang Key Laboratory of Clinical psychopharmacology Xinxiang China Department of Material Science and Engineering, Nanjing Institute of Technology, Nanjing 211167, P. R. China Medical Records Department Women and Children's Hospital of Chongqing Medical University Chongqing China Department of Spinal Cord Injury Rehabilitation, China Rehabilitation Research Center, Beijing 100068, P.R. China Department of Radiology Peking University Third Hospital, 49 Huayuan North Road, Haidian District Beijing China Institute of Chinese Materia Medica, Academy of Chinese Medical Sciences, Beijing 100700, China Tumor Etiology and Screening Department of Cancer Institute and General Surgery, Key Laboratory of Cancer Etiology and Prevention in Liaoning Education Department, Key Laboratory of GI Cancer Etiology and Prevention in Liaoning Province The First Hospital of China Medical University Shenyang China College of Life Sciences Fujian Normal University Fuzhou 350117 China Medical Center of Burn Plastic and Wound Repair, The First Affiliated Hospital of Nanchang University , Nanchang 330006 , China Department of Radiology, West China Hospital, Sichuan University, Chengdu 610041, China. College of Materials Science and Engineering; Chongqing University; Chongqing 400044; China The State Key Laboratory of Bioreactor Engineering; East China University of Science and Technology; Shanghai 200237, PR China Department of Biomedical Engineering and ‡Department of Chemical and Biological Engineering, University at Buffalo, The State University of New York, Buffalo, New York 14260, United States Key Lab of Dairy Biotechnology and Safety Control College of Food Science and Technology Yangzhou University Yangzhou China State Key Laboratory of Food Science and Technology University of Nanchang Nanchang China Tumor Etiology and Screening Department of Cancer Institute and General Surgery the First Hospital of China Medical University Shenyang China; Key Laboratory of Cancer Etiology and Prevention in Liaoning Education Department the First Hospital of China Medical University Shenyang China; Key Laboratory of GI Cancer Etiology and Prevention in Liaoning Province the First Hospital of China Medical University Shenyang China Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, No. 16 Nanxiaojie, Dongzhimennei, Beijing 100700, China Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, United States National Resource Center for Chinese Materia Medica Chinese Academy of Chinese Medical Sciences (CACMS) Beijing China Fujian Provincial Key Laboratory of Haixia Applied Plant Systems Biology, Center for Genomics and Biotechnology, College of Agriculture, Fujian Agriculture and Forestry University, Fuzhou 350002, China; Guangxi Key Laboratory of Sugarcane Biology, Guangxi University, Nanning, Guangxi 530004, China Reproductive Medicine Center, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China; Tianjin International Joint Academy of Biomedicine, Analytical Test Department, No. 220, Dongting Road,Tianjin Economic and Technological Development Zone,Tianjin, 300457, P.R. China State Key Laboratory Breeding Base of Dao-di Herbs,National Resource Center for Chinese Materia Medica,China Academy of Chinese Medical Sciences Beijing 100700,China. Department of Urology, Huangshi Central Hospital, Affiliated Hospital of Hubei Polytechnic University, Edong Healthcare Group, Huangshi, Hubei, China; Hubei Key Laboratory of Kidney Disease Pathogenesis and Intervention, Huangshi, Hubei, China Department of Pathology, Xijing Hospital,Fourth Military Medical University,Xi'an,China Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Institute of Aging Research, Guangdong Medical University, Dongguan, China; The Scientific Research Center of Dongguan, Guangdong Medical University, Dongguan, China Department of Mechanical, Aerospace and Nuclear Engineering, Rensselaer Polytechnic Institute Troy, New YorkUSA Department of Hematology, First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233004, China Translational Medicine Center, Key Laboratory of Molecular Target & Clinical Pharmacology, School of Pharmaceutical Sciences & The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou 510260, P. R. China; Chinese Academy of Sciences (CAS) Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, Beijing, 100190, P. R. China School of Biological Engineering, Beijing Polytechnic, Beijing, People’s Republic of China Guangdong Key Laboratory for Genome Stability & Disease Prevention, Guangdong Provincial Key Laboratory of Regional Immunity and Diseases, Department of Pathology, Shenzhen University School of Medicine, Shenzhen, Guangdong, China Department of Cardiology Renmin Hospital of Wuhan University Wuhan P. R. China; Cardiovascular Research Institute of Wuhan University Wuhan P. R. China Department of Medical Oncology, Xuzhou Central Hospital, Xuzhou Medical University, XuZhou, China Department of Pathology, Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, China Department of Extra-Corporeal Circulation, Fuwai Hospital, Chinese Academy of Medical Science, Beijing 100037, China. Hubei Provincial Key Laboratory for Applied Toxicology, Hubei Provincial Center for Disease Control and Prevention, Wuhan, Hubei 430079, China Zhejiang University‐University of Edinburgh Institute Zhejiang University School of Medicine Key Laboratory of Tissue Engineering and Regenerative Medicine of Zhejiang Province Hangzhou Zhejiang Province 310058 China Division of Urology, Department of Surgery, The University of Hong Kong-Shenzhen Hospital, Shenzhen, P. R. China Division of Cardiology Department of Medicine Johns Hopkins University School of Medicine Baltimore MD USA Department of Radiology The Second Hospital, Dalian Medical University Dalian Liaoning People's Republic of China Department of Gastrointestinal Surgery, People's Hospital of Zhengzhou University, Zhengzhou, Henan 450003, P.R. China Department of Laboratory Medicine, Med+X Center for Manufacturing Department of Radiology, Department of Pathology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China The State Key Laboratory of Bioreactor Engineering; East China University of Science and Technology; Shanghai 200237; PR China; Key Laboratory for Ultrafine Materials of Ministry of Education Key Lab of Dairy Biotechnology and Safety Control, College of Food Science and Engineering, Yangzhou University, Jiangsu, China School of Chemical Engineering and Technology, Hebei University of Technology, Xiping Road, Tianjin 300401, P. R. China State Key Laboratory Breeding Base of Dao-di Herbs, National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, PR China and Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College, Beijing 100730, China Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University Chinese Academy of Sciences Key Laboratory of Computational Biology, Max Planck Independent Research Group on Population Genomics, CAS-MPG Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, CAS, Shanghai 200031, China College of Management, Southwest University for Nationalities, Chengdu 610041, China Department of Medical Oncology and Therapeutics Research, City of Hope Comprehensive Cancer Center and Beckman Research Institute, Duarte, California, USA Gene Therapy Program, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Department of Cell Biology, Second Military Medical University , Shanghai 200433, China State Key Laboratory of Cancer Biology, Department of Pathology, Xijing Hospital and School of Basic Medicine Fourth Military Medical University Xi'an Shaanxi China Guangzhou Women and Children's Medical Center Guangzhou China State Key Laboratory of Pathogen and Biosecurity, Institute of Microbiology and Epidemiology, Beijing, China. Department of Cardiology Renmin Hospital of Wuhan University Wuhan China; Cardiovascular Research Institute Wuhan University Wuhan China; Hubei Key Laboratory of Cardiology Wuhan China School of Artificial Intelligence, Optics and Electronics (iOPEN), Northwestern Polytechnical University, Xi’an, China Institute of Bioengineering and Nanotechnology 31 Biopolis Way, The Nanos Singapore 138669 Singapore Peking University Health Science Center Beijing China School of Nursing and School of Public Health, Yangzhou University, Yangzhou, China. Nagano College of Nursing, Komagane, Japan. The Department of Vascular and Interventional Radiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China The First Department of Critical Care Medicine, Gansu Provincial Hospital, Gansu, People’s Republic of China 2Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas. Cancer Biology Research Center (Key Laboratory of the Ministry of Education), Tongji Medical College, Huazhong University of Science and Technology, Tongji Hospital, Wuhan, People's Republic of China Institute of Bioengineering and Bioimaging, Agency for Science, Technology and Research (ASTAR), 31 Biopolis Way, #07-01, The Nanos, 138669 Singapore Children's Hospital of Fudan University Shanghai China Clinical Nutrition Department, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China Department of Mechanical, Aerospace & Nuclear Engineering, Rensselaer Polytechnic Institute, Troy, New York 12180-3590, United States Tumor Etiology and Screening Department of Cancer Institute and General Surgery, The First Affiliated Hospital of China Medical University, and Key Laboratory of Cancer Etiology and Prevention (China Medical University), Liaoning Provincial Education Department, Shenyang 110001, China Department of Interventional Radiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China Department of Cardiology Renmin Hospital of Wuhan University Wuhan 430060 PR China; Cardiovascular Research Institute Wuhan University Wuhan 430060 PR China; Hubei Key Laboratory of Cardiology Wuhan 430060 PR China Center for Craniofacial Molecular Biology, University of Southern California, Los Angeles, United States Central Laboratory of Hefei Binhu Hospital, Hefei 230061, China. Department of Pathology, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, China College of Food Science and Engineering Jilin Univ Changchun China School of Public Health Peking University Beijing China Intensive Care Department of Chongqing Ninth People's Hospital Chongqing China Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, PR China; Cardiovascular Research Institute of Wuhan University, Wuhan 430060, PR China; Hubei Key Laboratory of Cardiology, Wuhan 430060, PR China Department of Intensive Care Unit (ICU), Gansu Provincial Hospital, Lanzhou, China National Resource Center for Chinese Materia Medica, Chinese Academy of Chinese Medical Sciences (CACMS), Beijing 100700, People’s Republic of China Tumor Etiology and Screening Department of Cancer Institute and General Surgery, The First Affiliated Hospital of China Medical University, Key Laboratory of Cancer Etiology and Prevention, China Medical University, Liaoning Provincial Education Department, Shenyang, Liaoning, China State Key Laboratory of Molecular Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, 333 Haike Road, Shanghai 201203, China Biometrics, Vaccines and Immune Therapies, BioPharmaceuticals Research and Development, AstraZeneca , Gaithersburg, Maryland , USA Department of Dermatology, Gansu Provincial Central Hospital; Department of Dermatology, Gansu Provincial Maternity and Child-Care Hospital, Lanzhou, China 1Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas. Department of Tumor Etiology and Screening, Cancer Institute and General Surgery, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China (mainland) School of Electrical, Computer and Energy Engineering, Arizona State University, Tempe, Arizona; Department of Spinal Cord Injury Rehabilitation, China Rehabilitation Research Center, Beijing, People’s Republic of China; China Rehabilitation Research Center, School of Rehabilitation Medicine, Capital Medical University, Beijing, People’s Republic of China Reproductive Medicine Center, The First Affiliated Hospital, Sun Yat-Sen University, 58, Zhongshan Road II, Guangzhou, China Department of Pathology, Basic Medicine School The Fourth Military Medical University Xi'an Shaanxi China Department of Neurology, The First Affiliated Hospital Zhejiang University School of Medicine Hangzhou China Department of Medical Oncology, City of Hope, Duarte, CA, USA School of Chemistry and Chemical Engineering; University of Jinan; Jinan; P. R. China Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Northwest A&F University , Yangling, China; Key Laboratory for Prevention and Control of Major Ruminant Diseases, Ministry of Agriculture and Rural Affairs , Yangling, China Beijing Institute of Biotechnology and Engineering Research Center for Biomaterials of Ministry of Education East China University of Science and Technology Shanghai China Department of Infection Public Health Clinical Center of Chengdu Chengdu Sichuan Province China College of Chemistry and Chemical Engineering, Central South University, Changsha, Hunan, 410083, P. R. China. State Key Laboratory Breeding Base of Dao-di Herbs, National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China State Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Sciences, No. 20 Dongda Street, Fengtai District, Beijing 100071, People’s Republic of China, and National Center of Biomedical Analysis, Beijing, 100850, People’s Republic of China Department of Pediatrics; First Affiliated Hospital, Guangxi Medical University; Nanning China Department of Oncology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, P.R. China College of Agriculture and Biotechnology, Hunan University of Humanities, Science and Technology, Loudi 417000, China; Quality Inspection Department, Hunan Ava Seeds Co., Ltd., Changsha 410128, China From the Division of Cardiology, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD (M.Z., E.T., D.-i.L., T.N., S.H., A.J., T.N., D.B., Y.Y., D.A.K.); Cardiovascular Division, King's College London, British Heart Foundation Centre, London, UK (C.X.C.S., A.M.S.); and The Rayne Institute, Kings College London, St. Thomas Hospital, London, UK (P.E.). School of Chemistry, University of New South Wales, Sydney, NSW 2052, Australia Key Laboratory of Animal Epidemiology and Zoonosis of Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, Beijing, China Department of Bioengineering, University of California San Diego, La Jolla, California, USA State Key Laboratory Breeding Base of Dao-di Herbs, National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China School of Chemistry and Chemical Engineering, University of Jinan 1 , Jinan 250022, China Department of Applied Chemistry School of Chemistry and Materials Science Hefei National Research Center for Physical Sciences at the Microscale University of Science and Technology of China Hefei Anhui 230026 China Tianjin Key Laboratory of Structure and Performance for Functional Molecules, Key Laboratory of Inorganic−Organic Hybrid Functional Materials Chemistry (Tianjin Normal University), Ministry of Education; College of Chemistry, Tianjin Normal University, Tianjin 300387, People’s Republic of China Department of Immunology, Anhui Medical University, Hefei, Anhui 230032, People's Republic of China. Clinical Trial Research Center The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University Luzhou China Emergency Department, The Affliated Hospital of Guizhou Medical University, Guiyang, China. Department of Ultrasound, Chongqing Traditional Chinese Medicine Hospital, Chongqing, 400010, China Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin 300072, P. R. China Departments of Surgery and Medical Physiology, Texas A&M University Health Science Center, Temple, Texas 76504 Nanjing Normal University School for Ecological and Environmental Sciences, Northwestern Polytechnical University, Xi’an, China Technology Development Center, Guilin Guiye Machinery Co., Ltd., Guilin 541119, China Department of Endocrinology and Metabolism The Second Xiangya Hospital Central South University Changsha, Hunan China School of Chemistry & Chemical Engineering, Yangzhou University, Yangzhou, Jiangsu 225002, China Institute of Aging Research, Guangdong Medical University, Dongguan, P.R. China; Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Dongguan, P.R. China; Institute of Biochemistry & Molecular Biology, Guangdong Medical University, Zhanjiang, P.R. China 1Department of Obstetrics, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, China Institute of Life Science and School of Life Science Nanchang University Nanchang Jiangxi China Key Laboratory of Carcinogenesis and Translational Research, (Ministry of Education), Department of Integration of Chinese and Western Medicine, Peking University Cancer Hospital & Institute, Beijing 100142, P. R. China Institute of Aging Research Guangdong Medical University Dongguan China; Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics Guangdong Medical University Dongguan China; The Scientific Research Center of Dongguan Guangdong Medical University Dongguan China Graduate School Beijing University of Chinese Medicine Beijing China; Department of Pediatrics China‐Japan Friendship Hospital Beijing China Tumor Etiology and Screening Department of Cancer Institute and General Surgery, The First Affiliated Hospital of China Medical University, Key Laboratory of Cancer Etiology and Prevention Liaoning Provincial Education Department China Medical University Shenyang China Laboratory of Morphology, Department of Basic Medical Sciences Shanxi Medical University Taiyuan China Hematology Center, Beijing Key Laboratory of Pediatric Hematology Oncology, National Key Discipline of Pediatrics (Capital Medical University), Key Laboratory of Major Diseases in Children, Ministry of Education, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, China College of Veterinary Medicine, China Agricultural University, Beijing 100193, China Tumor Etiology and Screening Department of Cancer Institute and General Surgery The First Affiliated Hospital of China Medical University and Key Laboratory of Tumor Etiology and Prevention in Liaoning Province Shenyang China Department of Pathology, The Third Xiangya Hospital of Central South University, Changsha, Hunan 410013, PR China Department of Nuclear Medicine, First Affiliated Hospital of Bengbu Medical College, Bengbu 233030, China. 2Department of Medical Oncology and Therapeutic Research, City of Hope National Medical Center, Duarte, California. School of Basic Medical Sciences, Southwest Medical University, Luzhou 646000, China Department of Urology, The University of Hong Kong-Shenzhen Hospital, Shen Zhen 518000, China Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Institute of Aging Research, Guangdong Medical University, Dongguan 523808, China China Academy of Chinese Medical Sciences National Resource Center for Chinese Materia Medica, , Beijing 100700, China National Laboratory of Solid State Microstructures and Department of Physics, Nanjing University, Nanjing 210093, P. R. China Tianjin Key Laboratory of Molecular Optoelectronic Science, Department of Chemistry, Tianjin University, Tianjin, 300354, People’s Republic of China Key Laboratory of Computational Biology, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences , Shanghai 200031 , China Shanghai Key Laboratory of New Drug Design, State Key Laboratory of Bioreactor Engineering, School of Pharmacy, East China University of Science & Technology, Shanghai 200237, China College of Materials Science and Engineering, Chongqing University, Chongqing 400044, China; National Engineering Research Center for Magnesium Alloys, Chongqing University, Chongqing 400044, China Affiliated Hospital of Yangzhou University Yangzhou China Department of Anesthesia, Tianjin Medical University General Hospital, Tianjin, China; Tianjin Institute of Anesthesiology, Tianjin, P.R. China Department of Cardiology Renmin Hospital of Wuhan University Wuhan China; Cardiovascular Research Institute of Wuhan University Wuhan China Hubei Key Laboratory of Natural Products Research and Development, College of Biological and Pharmaceutical Sciences, China Three Gorges University, Yichang, Hubei 443002, China Department of Clinical Hematology, Third Military Medical University, Chongqing 400038, PR China. Department of Laboratory, Yushan Campus Hospital, Hospital of Ocean University of China, Qingdao, P. R. China State Key Laboratory of Food Science and Technology Univ. of Nanchang Nanchang 330047 Jiangxi China School of Physics and Wuhan National High Magnetic Field Center Huazhong University of Science and Technology Wuhan 430074 China Chinese Academy of Medical Sciences Research Unit(No.2019RU057), National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences Beijing 100700, China. National Medical Center for Major Public Health Events Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan People's Republic of China From the Department of Cardiology, Renmin Hospital of Wuhan University, China (Y.Y., L.Y., Q.-Q.W., H.Z., Y.-G.J., Z.-Y.B., W.D., Z.Y., D.-F.S., H.L., Q.-Z.T.); and Cardiovascular Research Institute of Wuhan University, China (Y.Y., L.Y., Q.-Q.W., H.Z., Y.-G.J., Z.-Y.B., W.D., Z.Y., D.-F.S., X.-F.Z., S.-S.W., H.L., Q.-Z.T.). College of Biological Engineering, Beijing Polytechnic, Beijing 100176, China Hubei Province Engineering and Technology Research Center for Fluorinated Pharmaceuticals, School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China Department of Chemical and Biomedical Engineering University of South Florida Tampa Florida 33620 First Oil Production Plant of Daqing Oilfield, Daqing Oilfield Co., Ltd, Daqing 163453, China College of Management; Southwest University for Nationalities; Chengdu; People's Republic of China The First Hospital of Shanxi Medical University , Taiyuan 030001 , China Gansu University of Chinese Medicine, Lanzhou 730000, PR China School of Foreign Languages of Zunyi Medical University, Zunyi, Guizhou, P.R. China Tumor Etiology and Screening Department of Cancer Institute and General Surgery The First Affiliated Hospital of China Medical University Shenyang China Tumor Etiology and Screening Department of Cancer Institute and General Surgery, Key Laboratory of Cancer Etiology and Prevention in Liaoning Education Department, Key Laboratory of GI Cancer Etiology and Prevention in Liaoning Province, First Hospital of China Medical University , Shenyang, China Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, People's Republic of China Department of Chemical and Biological Engineering, 1415 Engineering Drive, ‡Department of Chemistry, 1101 University Avenue, and §Genome Center of Wisconsin, 425G Henry Mall, University of Wisconsin—Madison, Madison, Wisconsin 53706, United States Department of Clinical Laboratory Taizhou Hospital of Zhejiang Province Taizhou Zhejiang Province China School of Chemistry and Molecular Engineering East China University of Science and Technology Shanghai P. R. China Department of Pathology, Capital Medical University, Beijing, China School of Materials Science and Engineering; Southwest University of Science and Technology; Mianyang; China Department of Medical Oncology Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, The Affiliated Cancer Hospital of Nanjing Medical University Nanjing China State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Biomedical Engineering Center, Hunan University, Key Laboratory for Bio-Nanotechnology and Molecule Engineering of Hunan Province, Changsha 410082, China 1 Department of Automatic Control, College of Mechatronics and Automation, National University of Defense Technology, Changsha, Hunan 410073, China and 2 Department of Statistics, Harvard University, Cambridge, MA 02138-2931, USA Research Center for Molecular Recognition and Synthesis, Department of Chemistry, Fudan University; Shanghai; P. R. China Department of Pathology Capital Medical University Beijing China Department of Neurology, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China Cedars-Sinai Medical Center, 127 S San Vicente Blvd, Los Angeles, CA 90048, USA Center for Craniofacial Molecular Biology University of Southern California (USC) Los Angeles CA USA Basic Medical College, Shanxi University of Chinese Medicine, Jinzhong, China; Department of Chinese Medicine, First Hospital of Shanxi Medical University, Taiyuan, China Reproductive Medicine Center The First Affiliated Hospital, Sun Yat‐sen University Guangzhou China; Guangdong Provincial Key Laboratory of Reproductive Medicine Guangzhou China Tumor Etiology and Screening Department of Cancer Institute and General Surgery; The First Affiliated Hospital of China Medical University, and Key Laboratory of Cancer Control in Liaoning Province; Shenyang China Department of Biomedical Engineering, University at Buffalo, The State University of New York, Buffalo, New York 14260, United States Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China;; Cardiovascular Research Institute of Wuhan University, Wuhan, China; and Graduate School, Beijing University of Chinese Medicine, Beijing, China; Department of Pediatrics, China-Japan Friendship Hospital, Beijing, China Department of Molecular Genetics and Microbiology,; Genetics Institute, University of Florida College of Medicine, 1600 Southwest Archer Road, Gainesville, FL 32610; and Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, Hubei 430060, P.R. China Department of Medical Oncology & Therapeutic Research City of Hope National Medical Center Duarte California USA Department of Radiation Oncology The University of Alabama at Birmingham Birmingham Alabama USA Hongqi Integrated Circuit (Zhuhai) Co., Ltd, China Department of Laboratory Medicine, The Seventh People’s Hospital affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China Department of Surgical Anesthesiology, Jingmen Central Hospital, Jingmen, China Key Laboratory of Computational Biology, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences , Shanghai , China Department of Radiology, Changhai Hospital, No. 168 Changhai Road, Shanghai, China Department of Otolaryngology, The Second People’s Hospital of Wuxi, 68 Zhong Shan Road, Wuxi 214002, Jiangsu, PR China Department of Cardiology Xijing Hospital Fourth Military Medical University Xi'an China Department of Neurophysiology and Neuropharmacology, Institute of Special Environmental Medicine and Co-innovation Center of Neuroregeneration, Nantong University, Nantong, Jiangsu Province, China Center for Craniofacial Molecular Biology, Herman Ostrow School of Dentistry, University of Southern California, Los Angeles, CA 90033, USA State Key Laboratory Breeding Base of Dao‐di Herbs, National Resource Center for Chinese Materia Medica China Academy of Chinese Medical Sciences Beijing P.R. China Central Laboratory of Binhu Hospital The Third Affiliated Hospital of Anhui Medical University Hefei Anhui China Department of Pathology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China Department of Neurology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China Department of Molecular Microbiology and Department of Genetics, Washington University Medical School, St. Louis, Missouri 631101;; Cancer Institute, China Medical University, Shenyang, China7; Department of Pathology Third Xiangya Hospital Central South University Changsha China 2East Carolina Diabetes and Obesity Institute, East Carolina University, Greenville, North Carolina, USA; 3Human Performance Laboratory, College of Health and Human Performance, East Carolina University, Greenville, North Carolina, USA School of Chemistry & Chemical Engineering; Yangzhou University; Siwangting Road 180; Yangzhou; China Eli Lilly Suzhou Pharmaceutical Co. Ltd. Shanghai China School of Pharmacy, Anhui University of Chinese Medicine Hefei 230012, China State Key Laboratory Breeding Base of Daodi Herbs, National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences Beijing 100700, China. Tumor Etiology and Screening Department of Cancer Institute and General Surgery, The First Hospital of China Medical University, Shenyang 110001, China; Key Laboratory of Cancer Etiology and Prevention in Liaoning Education Department, The First Hospital of China Medical University, Shenyang 110001, China Marine Agriculture Research Center, Tobacco Research Institute of Chinese Academy of Agricultural Sciences, 11 Keyuanjingsi Road, Laoshan, Qingdao, Shandong 266101, People’s Republic of China Department of Pathology and Pathophysiology, Fourth Military Medical University, Xi'an 710032, China. From the Department of Cardiology (H.Z., Z.-Y.B., J.Z., W.D., L.Y., D.-F.S., J.D., Y.Y., R.Z., Y.-F.L., X.H., H.L., Q.-Z.T.), Renmin Hospital of Wuhan University, Wuhan, China; Cardiovascular Research Institute of Wuhan University (H.Z., Z.-Y.B., J.Z., W.D., L.Y., D.-F.S., J.D., Y.Y., R.Z., Y.-F.L., X.H., H.L., Q.-Z.T.), Wuhan, China; Key Laboratory of Cardiovascular Remodeling and Function Research (H.G.), Chinese Ministry of Education and Chinese Ministry of Health, Qilu Hospital of Shandong... Department of Pancreatic Surgery, West China Hospital Sichuan University Chengdu Sichuan Province China China International Science and Technology Cooperation Base of Food Nutrition/Safety and Medicinal Chemistry; State Key Laboratory of Food Nutrition and Safety; Tianjin University of Science and Technology; Tianjin 300457; China College of Life Sciences, Sichuan Agricultural University, Ya’an 625000, China Gansu University of Traditional Chinese Medicine; The 940th Hospital of Joint Logistics Support Force of Chinese People, Lanzhou Department of Anesthesiology, Tianjin Medical University General Hospital, Tianjin 300052, P.R. China Intensive Care Unit, Ningbo Medical Center Lihuili Hospital, Ningbo, People’s Republic of China State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, Jiangxi, China State Key Laboratory Breeding Base of Dao-di Herbs, National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, PR China School of Nursing Southwest Medical University Luzhou Sichuan China Key Laboratory of Eco‐Environments in Three Gorges Reservoir Region (Ministry of Education) Chongqing Engineering and Technology Research Center for Sweetpotato School of Life Sciences Southwest University Chongqing 400715 People's Republic of China State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, Hubei, PR China Department of Bioinformatics and Computational Biology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA;Graduate Program in Structural and Computational Biology and Molecular Biophysics, Baylor College of Medicine, Houston, Texas, USA Department of Integrated Chinese and Western Medicine, Yantai Yuhuangding Hospital Affiliated to Qingdao University, Shandong, China Tianjin Translational Genomics Center, BGI-Tianjin, BGI-Shenzhen, Tianjin, China.; Binhai Genomics Institute, BGI-Tianjin, BGI-Shenzhen, Tianjin, China. Department of Clinical Hematology, Faculty of Medical Laboratory Examination, The Third Military Medical University, Chongqing 400038, China. School of Chemistry & Chemical Engineering, Yangzhou University, Siwangting Road 180, Yangzhou, Jiangsu, 225002, China Electronic Materials Research Laboratory, International Center for Dielectric Research, ‡Department of Engineering Mechanics, SV Laboratory, Xi’an Jiaotong University, Xi’an 710049, Shaanxi, People’s Republic of China School of Ecology and Environment, Northwestern Polytechnical University, Xi’an 710072, China. State Key Laboratory Breeding Base of Green Chemistry-Synthesis Technology, College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, People’s Republic of China Key Laboratory of Cancer Etiology and Prevention in Liaoning Education Department, the First Hospital of China Medical University, Shenyang, China; Tumor Etiology and Screening Department of Cancer Institute and General Surgery, the First Hospital of China Medical University, Shenyang, China; Key Laboratory of GI Cancer Etiology and Prevention in Liaoning Province, the First Hospital of China Medical University, Shenyang, China School of Pharmacy, Anhui University of Chinese Medicine Hefei 230012, China State Key Laboratory Breeding Base of Dao-di Herbs, National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences Beijing 100700, China. Department of Medical Quality Control and Health Affairs Management, the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institute of Nu-trition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, Key Laboratory of Biology and Genetic Improvement of Horticultural Crops, Ministry of Agriculture and Rural Affairs, College of Horticulture, South China Agricultural University, Guangzhou 510642, China; National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China Department of Pathology, The Third Xiangya Hospital, Central South University Changsha, China Haihe River Water Conservancy Commission, Ministry of Water Resources, Tianjin 300170, China. Physics and Applied Physics and Tumor Etiology and Screening Department of Cancer Institute and General Surgery, the First Hospital of China Medical University, Shenyang, LiaoNing, China; Key Laboratory of Cancer Etiology and Prevention in Liaoning Education Department, the First Hospital of China Medical University, Shenyang, LiaoNing, China; Key Laboratory of GI Cancer Etiology and Prevention in Liaoning Province, the First Hospital of China Medical University, Shenyang, LiaoNing, China Department of Medical Oncology and Experimental Therapeutics, City of Hope Comprehensive Cancer Center, Duarte, California, USA College of Mechanical and Electrical Engineering, Guangdong University of Petrochemical Technology, Maoming, 525000, People's Republic of China; School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin 150001, People's Republic of China Department of Anesthesiology, Tianjin Medical University General Hospital, Tianjin, China. State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences , Beijing 100000 , China Department of Pathology, Third Xiangya Hospital, Central South University, Changsha, Hunan 410011, China Department of Medical Oncology and Therapeutics Research, City of Hope National Medical Center, Duarte, CA, USA School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, P.R. China Department of Otolaryngology—Head and Neck Surgery, Wuxi People’s Hospital affiliated to Nanjing Medical University, Wuxi, Jiangsu province, China Department of Medical Oncology and Therapeutics Research, City of Hope Medical Center, Duarte, CA, United States School of Computer Engineering, Nanyang Technological University, N4, 50 Nanyang Avenue, Singapore 639798, Singapore Rensselaer Polytechnic Institute 2 Mechanical, Aerospace, and Nuclear Engineering Department, , Troy, New York 12180-3590, USA Department of Obstetrics The Fourth Hospital of Harbin Medical University Harbin Heilongjiang P.R. China Center for Craniofacial Molecular Biology, University of Southern California, Los Angeles, CA, United States. Electronic address: yuan164@usc.edu. Department of Thyroid and Breast Surgery, Wuhan Number 1 Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China State Key Laboratory of Dao-di Herbs, National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China Department of Medical Oncology, Xuzhou Central Hospital Clinical School of Xuzhou Medical University Xuzhou China Novogene Bioinformatics Institute, Beijing, China Department of Anesthesiology Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine Shanghai China †Central Laboratory of Binhu Hospital, The Third Affiliated Hospital of Anhui Medical University, Hefei 230601, People’s Republic of China; and Guangdong Research Center for Interfacial Engineering of Functional Materials, College of Materials Science and Engineering, Shenzhen University, Shenzhen 518060, China; Department of Applied Chemistry, School of Chemistry and Materials Science, Hefei National Research Center for Physical Sciences at the Microscale, University of Science and Technology of China, Hefei, Anhui 230026, China Department of Cardiology Renmin Hospital of Wuhan University Wuhan 430060 PR China Key Lab of Dairy Biotechnology and Safety Control; College of Food Science and Engineering; Yangzhou University; Yangzhou; China Tianjin Key Laboratory of Molecular Optoelectronic Science, Department of Chemistry, Tianjin University, Tianjin 300354, P. R. China Marine Mammal and Marine Bioacoustics Laboratory, Institute of Deep-sea Science and Engineering, Chinese Academy of Sciences, Sanya 572000, China;; School of Ecology and Environment, Northwestern Polytechnical University, Xi’an 710072, China; The State Key Laboratory of Bioreactor Engineering and Key Laboratory for Ultrafine Materials of Ministry of Education, East China University of Science and Technology, Shanghai 200237, People’s Republic of China Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland Key Laboratory for Ultrafine Materials of Ministry of Education, East China University of Science and Technology, Shanghai 200237, P. R. China. Department of Applied Chemistry School of Chemistry and Materials Science Hefei National Research Center for Physical Sciences at the Microscale University of Science and Technology of China 230026 Hefei Anhui China HuidaGene Therapeutics Co. , Ltd., Shanghai 200131 , China Department of Medical Oncology, Xuzhou Central Hospital, Xuzhou Medical University, Xuzhou, 221009, China The Second Clinical College, Tongji Medical College Molecular Pharmacology Research Center, School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang, China Tumor Etiology and Screening Department of Cancer Institute and General Surgery, Key Laboratory of Cancer Etiology and Prevention of Liaoning Provincial Education Department, The First Affiliated Hospital of China Medical University, Shenyang, China Institute of Aging Research, Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Guangdong Medical University, Dongguan, Guangdong 523808, P.R. China State Key Laboratory of Dao-di Herbs Breeding Base, National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China. Department of Applied Chemistry, School of Chemistry and Materials Science, Hefei National Laboratory for Physical Sciences at the Microscale, University of Science and Technology of China, Hefei, Anhui 230026, People’s Republic of China State Key Laboratory Breeding Base of Dao-di Herbs，National Resources Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijng 100700, China. Tianjin Key Laboratory of Molecular Optoelectronic Science Department of Chemistry Tianjin University Tianjin 300354 P. R. China State Key Laboratory of Pathogens and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing 100071, P.R. China College of Management; Southwest University for Nationalities; P. R. China School of Materials Science and Engineering University of New South Wales Sydney Australia National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China. The Fourth Affiliated Hospital, Zhejiang University School of Medicine, Jinhua, Zhejiang 322000, China Department of Oncology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China. Department of Radiology, West China Hospital Sichuan University Chengdu China Tumour Etiology and Screening Department of Cancer Institute and General Surgery, First Hospital of China Medical University, and Key Laboratory of Cancer Aetiology and Prevention (China Medical University), Liaoning Provincial Education Department, Shenyang, Liaoning Province, China Department of Medical Oncology and Therapeutic Research, City of Hope National Medical Center and Beckman Research Institute, Duarte, CA, USA The First Hospital of China Medical University, Key Laboratory of GI Cancer Etiology and Prevention in Liaoning Province, Shenyang, LiaoNing, China; The First Hospital of China Medical University, Tumor Etiology and Screening Department of Cancer Institute and General Surgery, Shenyang, LiaoNing, China; The First Hospital of China Medical University, Key Laboratory of Cancer Etiology and Prevention in Liaoning Education Department, Shenyang, LiaoNing, China Tumor Etiology and Screening Department of Cancer Institute and General Surgery, the First Affiliated Hospital of China Medical University, Shenyang 110001, China; Key Laboratory of Cancer Etiology and Prevention, China Medical University, Liaoning Provincial Education Department, Shenyang 110001, China Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xi’an, Shannxi 710032, China Jiangsu Provincial Key Laboratory of Special Children’s Impairment and Interventionl, Nanjing Normal University of Special Education, Nanjing, China Department of Infectious Diseases, Weifang Yidu Central Hospital, Qingzhou 262500, China School of Nursing Yangzhou University Yangzhou China; Department of Nursing Yangzhou University Affiliated Hospital Yangzhou China Key Laboratory of Rubber-Plastics, Ministry of Education/Shandong Provincial Key Laboratory of Rubber-Plastics, Qingdao University of Science & Technology, Qingdao City 266042, People’s Republic of China State Key Laboratory of Dao-di Herbs Breeding Base, National Resources Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China. Department of Pancreatic Surgery, West China Hospital, Sichuan University , Chengdu, Sichuan Province , China The State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, P. R. China Department of Urology, Huangshi Central Hospital, Affiliated Hospital of Hubei Polytechnic University, Huangshi, China; Hubei Key Laboratory of Kidney Disease Pathogenesis and Intervention, Huangshi, China Department of Periodontology School and Hospital of Stomatology Tianjin Medical University Tianjin China Institute of Bioengineering and Nanotechnology, 31 Biopolis Way, The Nanos #04-01, Singapore 138669, Singapore Department of Chemistry Tianjin Key Laboratory of Molecular Optoelectronic Science Tianjin University Tianjin 300354 P. R. China Medical Nursing Office, School of Nursing, Yangzhou University, Yangzhou, China.; Nagano College of Nursing, Komagane, Japan. 10City of Hope Cancer Center, Duarte, California. Key Laboratory for Ultrafine Materials of Ministry of Education, The State Key Laboratory of Bioreactor Engineering, and Engineering Research Center for Biomedical Materials of Ministry of Education, East China University of Science and Technology, Shanghai 200237, People’s Republic of China Department of Chemistry, School of Sciences, Tianjin University, Tianjin 300072, People’s Republic of China State Key Laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering, Chongqing Medical University, Chongqing, China; Sichuan Provincial Center for Gynaecology and Breast Diseases, The Affiliated Hospital of Southwest Medical University, Luzhou, China Guangxi Scientific Experiment Center of Mining, Metallurgy and Environment, Guilin University of Technology, Guilin 541004, PR China The State Key Laboratory of Bioreactor Engineering East China University of Science and Technology; Shanghai; China Institute of Neuroscience, Kunming Medical College, Kunming 650031, China. Tumor Etiology and Screening Department of Cancer Institute and General Surgery, the First Affiliated Hospital of China Medical University, and Key Laboratory of Cancer Etiology and Prevention (China Medical University), Liaoning Provincial Education Department, Shenyang, China Engineering Research Center of Cell & Therapeutic Antibody, Ministry of Education, School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China Department of Medical Oncology & Therapeutics Research City of Hope Duarte California USA Department of Medical Records Women and Children's Hospital of Chongqing Medical University Chongqing China Department of Medical Oncology and Therapeutics Research, City of Hope Comprehensive Cancer Center, Duarte, CA 91010, USA Key Laboratory of Preparation and Applications of Environmentally Friendly Materials (Jilin Normal University), Ministry of Education, Changchun, 130103, China Key Laboratory of Integrated Transportation Big Data Application Technology in Transportation Industry, Beijing Jiaotong University, Beijing 100044, China Department of Critical Care Medicine, Ningbo Medical Center Lihuili Hospital, Ningbo, Zhejiang 315000, China. State Key Laboratory of Pathogen and Biosecurity Beijing Institute of Microbiology and Epidemiology China Department of Cardiology, Xijing Hospital, Air Force Military Medical University (Fourth Military Medical University); Xi'an-China. yuanfmmu@163.com. Department of Cardiology Renmin Hospital of Wuhan University Wuhan China; Hubei Key Laboratory of Metabolic and Chronic Diseases Wuhan China Department of Pharmacy, Medical College of Chinese People's Armed Police Forces, Tianjin 300162, China. Department of Pathology and Pathophysiology, Fourth Military Medical University, Xi’an 710032, China School of Foreign Languages of Zunyi Medical University, Zunyi, Guizhou 563003, P. R. China Department of Pathophysiology, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing, China Department of Pancreatic Surgery West China Hospital Sichuan University Chengdu 610041 P. R. China Institute of Special Environmental Medicine, Co-innovation Center of Neuroregeneration, Nantong University , Nantong 226001 , China School of Chemistry and Chemical Engineering, Nanjing University of Science and Technology, Nanjing 210094, China Department of Medical Oncology & Therapeutics Research, City of Hope National Medical Center , Duarte, CA , USA Shenzhen Birth Defect screening project laboratory, BGI-Shenzhen, Shenzhen, China 1st Affiliated Hospital of China Medical University Shenyang China The University of Sydney,School of Computer Science, Faculty of Engineering,Sydney,Australia College of Food Science and Technology Shanghai Ocean University Shanghai China; National R&D Branch Center for Freshwater Aquatic Products Processing Technology (Shanghai) Shanghai China Department of Obstetrics and Gynecology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 644300, P.R. China Department of Anesthesiology, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, China Tumor Etiology and Screening, Department of Cancer Institute and General Surgery, The First Affiliated Hospital of China Medical University, Shenyang, China Dept. of Chemical and Biomedical Engineering University of South Florida Tampa FL 33620 Department of Statistics, Harvard University, Cambridge, Massachusetts 02138 Institute of Life Science and School of Life Science Nanchang University Nanchang People's Republic of China Department of Pathology, The Third Xiangya Hospital, Central South University, Changsha, P.R. China Key Laboratory of Green Utilization of Critical Non-metallic Mineral Resources of Ministry of Education, Wuhan, Hubei 430070, People’s Republic of China; Hubei Key Laboratory of Mineral Resources Processing and Environment, Wuhan University of Technology, Wenzhi Street 34, Wuhan, Hubei 430070, People’s Republic of China; Doctorado Institucional de Ingeniería y Ciencia de Materiales, Universidad Autonoma de San Luis Potosi, Av. Sierra Leona 530, San Luis Potosi 78210, Mexico Department of Chemical and Biological Engineering University at Buffalo, The State University of New York Buffalo New York USA School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin 150001, People's Republic of China Methadone Maintenance Treatment Clinic, 109 Hospital, Taiyuan, Shanxi, China Tumor Etiology and Screening Department of Cancer Institute and General Surgery, the First Hospital of China Medical University, Shenyang, China;; Key Laboratory of Cancer Etiology and Prevention (China Medical University) Liaoning Provincial Education Department, Shenyang, China;; National Clinical Research Center for Digestive Diseases, Xi’an, China Tumor Etiology and Screening Department of Cancer Institute and General Surgery, The First Affiliated Hospital of China Medical University, Key Laboratory of Cancer Etiology and Prevention China Medical University, Liaoning Provincial Education Department, Shenyang 110001, China The State Key Laboratory of Bioreactor Engineering; East China University of Science and Technology; Shanghai 200237, PR China; Key Laboratory for Ultrafine Materials of Ministry of Education; East China University of Science and Technology State Key Laboratory of Pathogen and Biosecurity Institute of Microbiology and Epidemiology AMMS Beijing China School of Rehabilitation Science, Jiangsu Provincial Key Laboratory of Special Children’s Impairment and Intervention, Nanjing Normal University of Special Education, Nanjing, China Department of Clinical Laboratory, The Affiliated Hospital of Qingdao University Qingdao 266000, Shandong Province, People's Republic of China. Division of Disease Models, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan.; Department of Biochemistry, Nagoya University Graduate School of Medicine, Nagoya, Japan. Department of Neurology Shanghai Jiao Tong University Affiliated Sixth People's Hospital China Institute of Biomaterials, East China University of Science and Technology, Shanghai 200237, China. wpfyy@263.net Department of Pathology, Capital Medical University, Beijing, Fengtai, China School of Psychology Nanjing Normal University Nanjing China Guangdong Research Center for Interfacial Engineering of Functional Materials College of Materials Science and Engineering Shenzhen University Shenzhen 518060 China; Department of Applied Chemistry School of Chemistry and Materials Science Hefei National Research Center for Physical Sciences at the Microscale University of Science and Technology of China Hefei Anhui 230026 China Department of Cardiology; RenMin Hospital of Wuhan University; Wuhan 430060; China; Cardiovascular Research Institute of Wuhan University Basic Medical Sciences Center Shanxi Medical University Taiyuan China; Key Laboratory of Cellular Physiology (Shanxi Medical University) Ministry of Education Taiyuan China Hubei Province Engineering and Technology Research Center for Fluorinated Pharmaceuticals and School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China Xiyuan Hospital,China Academy of Chinese Medicine Sciences Beijing 100091,China. Center for Craniofacial Molecular Biology, University of Southern California, Los Angeles, CA 90033, USA Xi’an Jiaotong University The Key Laboratory of Biomedical Information Engineering of the Ministry of Education, Department of Biomedical Engineering, School of Life Science and Technology, , Xi’an 710049, People’s Republic of China College of Life Sciences; Fujian Agriculture and Forestry University; Fuzhou; China; Mycological Research Center National Resource Center for Chinese Meteria Medica, Chinese Academy of Chinese Medical Sciences , 100700, Beijing , China Tumor Etiology and Screening Department of Cancer Institute and General Surgery, The First Affiliated Hospital of China Medical University, and Key Laboratory of Cancer Etiology and Prevention (China Medical University), Liaoning Provincial Education Department, Shenyang 110001, China; National Clinical Research Center for Digestive Diseases, Xi’an 110001, China School of Physics and Wuhan National High Magnetic Field Center; Huazhong University of Science and Technology; Wuhan 430074; China Tumor Etiology and Screening Department of Cancer Institute and General Surgery, The First Affiliated Hospital of China Medical University, and Key Laboratory of Cancer Etiology and Prevention, Liaoning Provincial Education Department, Shenyang 110001, China. Department of Applied Chemistry, School of Chemistry and Materials Science, Hefei National Laboratory for Physical Sciences at the Microscale, University of Science and Technology of China, Hefei, Anhui 230026, China National Laboratory of Solid State Microstructures and Department of Physics Nanjing University Nanjing 210093 P. R. China Department of Gynaecology, Shenzhen Bao’an Chinese Medicine Hospital, Guangzhou University of Chinese Medicine, Shenzhen, China School of Artificial Intelligence, OPtics and ElectroNics (iOPEN), Northwestern Polytechnical University, Xi'an, P.R. China Department of Pathology, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China 12Department of Medical Oncology & Therapeutics Research, City of Hope National Medical Center, Duarte, California. Department of Nursing, Affiliated Hospital of Yangzhou University Yangzhou University Yangzhou China Department of Civil, Environmental and Architectural Engineering and Environmental Research Center, Missouri University of Science and Technology, Rolla, Missouri 65409, United States Department of Urology Huangshi Central Hospital Affiliated Hospital of Hubei Polytechnic University Edong Healthcare Group Huangshi China Cancer Biology Research Center (Key Laboratory of the Ministry of Education); Departments of; Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China Department of Otolaryngology, the Wuxi First People's Hospital, Wuxi, 214002, China. yuanyuanblue1@163.com Hematology Center, Beijing Key Laboratory of Pediatric Hematology Oncology, National Key Discipline of Pediatrics (Capital Medical University), Key Laboratory of Major Diseases in Children, Ministry of Education, Beijing Children’s Hospital, National Center for Children’s Health, Beijing, PR China University of Science and Technology Beijing Research Center for Molecular Recognition and Synthesis; Department of Chemistry; Fudan University; Shanghai 200433; P. R. China Department of Urology, The University of Hongkong-Shenzhen Hospital, Shenzhen, China Tumor Etiology and Screening Department of Cancer Institute and General Surgery, The First Affiliated Hospital of China Medical University, Shenyang, People's Republic of China.; Key Laboratory of Cancer Etiology and Prevention (China Medical University), Liaoning Provincial Education Department, Shenyang, People's Republic of China. National Medical Center for Major Public Health Events Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan People's Republic of China; Cancer Biology Research Center (Key Laboratory of Chinese Ministry of Education) Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan People's Republic of China; Department of Gynecology and Obstetrics Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan People's Republic of China Department of Catheterization-Room, Tianchang Traditional Chinese Medicine Hospital, Chuzhou 239300, Anhui, China Key Laboratory of Rubber-Plastics, Ministry of Education/Shandong Provincial Key Laboratory of Rubber-plastics, Qingdao University of Science & Technology, Qingdao City 266042, People’s Republic of China Department of Radiology West China Hospital of Sichuan University Chengdu China Laboratory of Animal Fat Deposition and Muscle Development, College of Animal Science and Technology, Northwest A&F University, Yangling 712100, China. Beijing Engineering Research Center of Industrial Spectrum Imaging Department of Dermatology Xijing Hospital, Fourth Military Medical University Xi'an P. R. China State Key Laboratory Breeding Base of Dao-di Herbs, National Resource Center for Materia Medica,China Academy of Chinese Medical Sciences Beijing 100700, China. 1 Graduate Program in Structural and Computational Biology and Molecular Biophysics, Baylor College of Medicine, 2Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, 3Department of Statistics, Rice University, Houston, TX 77005, 4Department of Statistics, University of Illinois at Urbana-Champaign, Champaign, IL 61801 And 5Department of Statistics, Texas A&M University, College Station, TX 77843, USA; 1 Graduate Program in Structural and Computational Biology and Molecular Biophysics, Baylor College of Medicine, 2Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, 3Department of Statistics, Rice University, Houston, TX 77005, 4Department of Statistics, University of Illinois at Urbana-Champaign, Champaign, IL 61801 And 5Department of Statistics, Texas A&M University, College Station, TX 77843, USA Department of Mathematics & Statistics Auburn University Auburn Alabama Department of Pharmacy, Hangzhou Red Cross Hospital (Hangzhou Chest Hospital Affiliated to Zhejiang University Medical College), Hangzhou, People’s Republic of China Department of Pharmacy, The Affiliated Wuxi Matemity and Child Health Care Hospital of Nanjing Medical University, Wuxi 214000, China Peking University School of Public Health Beijing China School of Foreign Languages of Zunyi Medical University, Zunyi 563000, China State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China Beijing University of Chinese Medicine, Beijing, China; Department of Pediatrics, China-Japan Friendship Hospital, Beijing, China Department of Pathology, Third Xiangya Hospital, Central South University, Changsha, Hunan , P.R. China State Key Laboratory of Food Science and Technology Nanchang University Nanchang Jiangxi 330047 China Trinity Life Sciences Waltham Massachusetts Department of Otolaryngology The First People's Hospital of Yancheng Yancheng Jiangsu China Tumor Etiology and Screening Department of Cancer Institute and General Surgery, The First Affiliated Hospital of China Medical University, Key Laboratory of Cancer Control in Liaoning Province, Shenyang 110001, China. yyuan@mail.cmu.edu.cn Department of Gastroenterology The First Affiliated Hospital, Henan Chinese Medical University China HUIEDIT Therapeutics Inc. , Shanghai 200131, China College of Management, Southwest University for Nationalities, No. 16 South Section 4, Yihuan Road, Chengdu 610041, People’s Republic of China Key Laboratory for Ultrafine Materials of Ministry of Education School of Materials Science and Engineering and Engineering Research Center for Biomedical Materials of Ministry of Education East China University of Science and Technology Shanghai 200237 P. R. China Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, China; Cardiovascular Research Institute, Wuhan University, Wuhan 430060, China; Hubei Key Laboratory of Cardiology, Wuhan 430060, China The Ohio State University 1 Nanoscale Science and Engineering Center for Affordable Nanoengineering of Polymeric Biomedical Devices, , Columbus, Ohio 43210, USA Institute of Aging Research, Guangdong Medical University, Dongguan 523808, China; Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Guangdong Medical University, Dongguan, China National Resource Center for Chinese Meteria Medica,China Academy of Chinese Medical Sciences Beijing 100700,China. Department of Materials Science; Sichuan University; Chengdu 610064; China Material Technology Research Center The Second Research Institute of Civil Aviation Administration of China Chengdu 610041 P. R. China School of Traditional Chinese Medicine,Guangdong Pharmaceutical University Guangzhou 510006,China State Key Laboratory of Dao-di Herbs Breeding Base,National Resource Center for Chinese Meteria Medica,China Academy of Chinese Medical Sciences Beijing 100700,China. Tianjin Key Laboratory of Molecular Optoelectronic Science, Department of Chemistry, Tianjin University, Tianjin 300354, China; Collaborative Innovation Center of Chemical Science and Engineering, Tianjin 300072, China College of Quartermaster Technology; Jilin University; Changchun, China Department of Neurology, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine , Shanghai , China School of Traditional Chinese Medicine,Guangdong Pharmaceutical University Guangzhou 510006, China State Key Laboratory Breeding Base of Dao-di Herbs,National Resource Center for Chinese Materia Medica,China Academy of Chinese Medical Sciences Beijing 100700,China. Institute of Bioengineering and Nanotechnology; Singapore 138669; Singapore Late Respiratory Inflammatory and Autoimmunity Biometrics, AstraZeneca, Gaithersburg, Maryland, USA Department of Anesthesiology, The First People's Hospital of Jingmen, Jingmen, Hubei 448000, P.R. China Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, China; Cardiovascular Research Institute of Wuhan University, Wuhan 430060, China; Hubei Key Laboratory of Cardiology, Department of Cardiology, Renmin Hospital of Wuhan University,Wuhan 430060, P.R. China Institute of Bioengineering and Nanotechnology, The Nanos, Singapore, Singapore Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, P. R. China; Cardiovascular Research Institute of Wuhan University, Wuhan, P. R. China; Hubei Key Laboratory of Cardiology, Wuhan, P. R. China Engineering Research Center for Biomedical Materials of Ministry of Education, East China University of Science & Technology, Shanghai 200237, PR China Department of Science and Education, Maternity and Child Care Center of Xinyu, Women and Children's Hospital of Xinyu Xinyu, Jiangxi Province, China. Xiyuan Hospital, China Academy of Chinese Medical Science, Beijing 100091, China. School of Life Sciences, University of Science and Technology of China, Hefei, Anhui Province 230026, China College of Management; Southwest University for Nationalities; Chengdu 610041; P. R. China Institute of Life Science and School of Life Science, Nanchang University, No. 999, Xuefu Road, Honggutan New District, Nanchang, Jiangxi 330031, China Department of Medical Oncology, Affiliated Xuzhou Central Hospital, Southeast University, Xuzhou, China Department of Chemistry; College of Chemistry and Chemical Engineering; the MOE Key Laboratory of Spectrochemical Analysis and Instrumentation and iChEM; Xiamen University; Xiamen 361005 College of veterinary medicine, China Agricultural University, Beijing 100083, China. Department of Intensive Care Unit, Gansu Provincial People's Hospital, Gansu, China. Key Laboratory of Pathobiology, Department of Pathophysiology, Ministry of Education, College of Basical Medical Sciences, Jilin University, 126 Xinmin Street, Changchun 130012, China Institute of Bioengineering and Nanotechnology 31 Biopolis Way The Nanos Singapore 138669 Singapore Department of Thyroid and Breast Surgery Wuhan No. 1 Hospital Wuhan City China Guangdong Provincial Key Laboratory of Mental Health and Cognitive Science and Center for Studies of Psychological Application, School of Psychology, South China Normal University, Guangzhou, P.R. China College of Life Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, Fujian, People's Republic of China; Mycological Research Canter, College of Life Sciences, Fujian Agriculture and Forestry University, Fuzhou, 350002, People's Republic of China Key Laboratory of Rubber-Plastics, Ministry of Education/Shandong Provincial Key Laboratory of Rubber-plastics, Qingdao University of Science & Technology, Qingdao 266042, China Heilongjiang Provincial Key Laboratory of Environmental Microbiology and Recycling of Argo-Waste in Cold Region, College of Life Science and Technology, Heilongjiang Bayi Agricultural University, Daqing, People’s Republic of China The First School of Clinical Medicine, Lanzhou University, Lanzhou, China; Department of Anesthesiology, The First Hospital of Lanzhou University, Lanzhou University, Lanzhou, China Formerly City of Hope Comprehensive Cancer Center, Duarte, CA, USA; Currently: Cedars-Sinai Cancer Center, Los Angeles, CA, USA Center for Craniofacial Molecular Biology, University of Southern California, Los Angeles, CA, 90033, USA Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China; Cardiovascular Research Institute of Wuhan University, Wuhan, China; Hubei Key Laboratory of Cardiology, Wuhan, China Geriatric Medicine Department Beijing Jishuitan Hospital Beijing China School of Biological Engineering; Beijing Polytechnic; Beijing 100176; P.R. China Department of Cardiopulmonary Bypass; State Key Laboratory of Cardiovascular Medicine, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Science and Peking Union Medical College; Beijing China College of Management, Southwest University for Nationalities, Chengdu 610041, People’s Republic of China Departments of Medical Physiology and Surgery, Texas A & M University System Health Science Center, Temple, Texas 76504 General Machinery Section, Machinery Department, Patent Examination Cooperation Sichuan Center of the Patent Office (CNIPA), Chengdu, P.R. China Emergency Department, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100005, China. School of Computer Science, Northwestern Polytechnical University, Xi’an, China Tumor Etiology & Screening Department of Cancer Institute & General Surgery, the First Hospital of China Medical University, Shenyang 110001, PR China; Key Laboratory of Cancer Etiology & Prevention in Liaoning Education Department, the First Hospital of China Medical University, Shenyang 110001, PR China; Key Laboratory of GI Cancer Etiology & Prevention in Liaoning Province, the First Hospital of China Medical University, Shenyang 110001, PR China Center for Craniofacial Molecular Biology, University of Southern California Molecular Pharmacology Research Center School of Pharmaceutical Science Wenzhou Medical University Wenzhou Zhejiang China Institute of Bioengineering and Nanotechnology, 31 Biopolis Way, The Nanos #07-01, Singapore 138669, Singapore Hebei United University, Tangshan, Hebei Province 063000, China. Key Laboratory for Ultrafine Materials of Ministry of Education School of Materials Science and Engineering, and Engineering Research Center for Biomedical Materials of Ministry of Education East China University of Science and Technology Shanghai 200237 P. R. China Department of Physics, Nanjing University, Nanjing 210093, China Department of Cardiology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai 200092, China Key Laboratory of Bio‐Resource and Eco‐Environment of Ministry of Education, College of Life Sciences Sichuan University Chengdu China Tumor Etiology and Screening Department, China Medical University, Shenyang, China. School of Food and Bioengineering, Xihua University, Chengdu, Sichuan, China. Center for Craniofacial Molecular Biology, Herman Ostrow School of Dentistry University of Southern California, Los Angeles, California, USA Chongqing Key Laboratory of Soft Condensed Matter Physics and Smart Materials, College of Physics, Chongqing University, Chongqing 400044, China Department of Immunology, Anhui Medical University, Hefei 230032, China. Department of Chemical and Biomedical Engineering; University of South Florida; Tampa; USA Department of Radiology, Shanghai Changhai Hospital, Shanghai, China City of Hope Comprehensive Cancer Center and Beckman Research Institute, Duarte, California, USA Department of Radiology, The Second Hospital Dalian Medical University Dalian China State Key Laboratory for Conservation and Utilization of Subtropical Agro‐Bioresources, Guangxi Key Laboratory of Sugarcane Biology Guangxi University Guangxi 530004 China Center for Ecological and Environmental Sciences, Northwestern Polytechnical University, Xi’an, China;; Qingdao Research Institute, Northwestern Polytechnical University, Qingdao, China; Department of Pharmacy The First Affiliated Hospital of Xinjiang Medical University Urumqi Xinjiang China Graduate School, Beijing University of Chinese Medicine, Beijing, China; Department of Pediatrics, China–Japan Friendship Hospital, Beijing, China Department of Radiology West China Hospital Sichuan University Chengdu China Tumor Etiology and Screening Department of Cancer Institute and General Surgery, the First Affiliated Hospital of China Medical University Liaoning Provincial Education Department Shenyang China; Key Laboratory of Cancer Etiology and Prevention (China Medical University), Liaoning Provincial Education Department Shenyang China Tianjin Key Laboratory of Molecular Optoelectronic Science; Department of Chemistry; Tianjin University; Tianjin 300354; P. R. China State Key Laboratory Breeding Base of Dao-di Herbs, National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, P.R. China; Department of Cardiology, Shanghai East Hospital, Tongji University Chinese Medicine Hospital, Occupation University of Wuwei; Gansu University of Traditional Chinese Medicine; The 94th Hospital of the Joint Logistic Support Force of the Chinese People's Liberation Army Institute of Pathology China Three Gorges University Yichang China; Department of Pathology Yichang Central People's Hospital Yichang China Green Chemistry Centre of Excellence, Department of Chemistry, University of York, York YO10 5DD, UK; Marine Agriculture Research Center, Tobacco Research Institute of Chinese Academy of Agricultural Sciences, Qingdao 266101, China National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, People's Republic of China Department of Radiology, The Second Hospital of Dalian Medical University, Dalian, PR China GCP Center the Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University Luzhou China Department of Radiology, The Second Hospital, Dalian Medical University, Shahekou, Dalian, PR China College of Materials Science and Engineering; Sichuan University; Chengdu 610064; China Departments of Molecular Microbiology and Genetics, Washington University Medical School, St. Louis, Missouri 631101;; Cancer Institute, China Medical University, Shenyang,5 and Department of Critical Care Medicine, Longhua Hospital Shanghai University of Traditional Chinese Medicine, Shanghai, China Department of Medical Oncology Xuzhou Central Hospital Xuzhou Medical University Xuzhou China Environmental Engineering, Texas A&M University—Kingsville, Kingsville, Texas, United States Department of Ultrasound, Delta Health Hospital Shanghai, Shanghai, China College of Physics, Changchun Normal University, Changchun 130032, China Department of Pathology, Third Xiangya Hospital, Changsha, Hunan 410013, China Department of Neurosurgery, Yantai Yuhuangding Hospital, Yantai, Shandong 264000, P.R. China Department of Gynecology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, P.R.ï¿½China Key Laboratory of Computational Biology, CAS‐MPG Partner Institute for Computational Biology, Chinese Academy of Sciences Shanghai China; Department of Computer Science and Computer Engineering, La Trobe University Melbourne Victoria Australia Changchun Normal University College of Physics CHINA Marine Mammal and Marine Bioacoustics Laboratory, Institute of Deep-sea Science and Engineering, Chinese Academy of Sciences , Sanya 572000, China; School of Ecology and Environment, Northwestern Polytechnical University , Xi’an 710072, China Tumor Etiology and Screening Department of Cancer Institute and General Surgery; The First Affiliated Hospital of China Medical University, Key Laboratory of Cancer Etiology and Prevention (China Medical University); Liaoning Provincial Education Department; Shenyang Liaoning 110001 China Tumor Etiology and Screening Department of Cancer Institute and General Surgery, the First Hospital of China Medical University, Shenyang, Liaoning, China; Key Laboratory of Cancer Etiology and Prevention in Liaoning Education Department, the First Hospital of China Medical University, Shenyang, Liaoning, China; Key Laboratory of GI Cancer Etiology and Prevention in Liaoning Province, the First Hospital of China Medical University, Shenyang, Liaoning, China Department of Ultrasound, The Second Hospital of Wuxi Affiliated to Nanjing Medical University, Wuxi, Jiangsu 214002, P.R. China School of Biosciences and Biopharmaceutics, Guangdong Pharmaceutical University, Guangzhou 510006, Guangdong, China. Department of Population Sciences, City of Hope Comprehensive Cancer Center, Duarte, CA School of Electrical, Computer, and Energy Engineering, Arizona State University, Tempe, Arizona Key Laboratory of Organic Chemistry of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China Department of Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA Departments of Surgery and Medical Physiology, Texas A & M University Health Science Center, Temple, Texas 76504 State Key Laboratory of Cancer Biology and Department of Pathology, Xijing Hospital, The Fourth Military Medical University, Xi'an, Shaanxi 710032, P.R. China CAS Key Laboratory of Quantum Information, University of Science and Technology of China, Hefei 230026, People’s Republic of China.; CAS Center for Excellence in Quantum Information and Quantum Physics, University of Science and Technology of China, Hefei 230026, People’s Republic of China. Qingdao University of Science and Technology, Key Laboratory of Rubber-Plastics, Ministry of Education/Shandong Provincial Key Laboratory of Rubber-Plastics, Qingdao City 266042, P. R. China Tumor Etiology and Screening Department of Cancer Institute and General Surgery, The First Hospital of China Medical University, Shenyang 110001, China; Key Laboratory of Cancer Etiology and Prevention in Liaoning Education Department, The First Hospital of China Medical University, Shenyang 110001, China; Key Laboratory of GI Cancer Etiology and Prevention in Liaoning Province, The First Hospital of China Medical University, Shenyang 110001, China Department of Neurology The First Affiliated Hospital, Zhejiang University School of Medicine Hangzhou China School of Physics and Wuhan National High Magnetic Field Center, Huazhong University of Science and Technology, Wuhan 430074, China Tumor Etiology and Screening Department of Cancer Institute, and Key Laboratory of Cancer Etiology and Prevention in Liaoning Education Department, the First Hospital of China Medical University, Shenyang, China; Key Laboratory of GI Cancer Etiology and Prevention in Liaoning Province, the First Hospital of China Medical University, Shenyang, China Tumor Etiology and Screening Department of Cancer Institute and General Surgery, The First Affiliated Hospital of China Medical University, Key Laboratory of Cancer Etiology and Prevention (China Medical University), Liaoning Provincial Education Department, Shenyang, Liaoning, China Division of Neurobiology and Physiology, Department of Basic Medical Sciences, Key Laboratory of Medical Neurobiology of the Ministry of Health, Zhejiang Province Key Laboratory of Neurobiology, Zhejiang University School of Medicine, Hangzhou 310058, China; School of Electrical and Information Engineering, Changsha University of Science and Technology, Changsha, China Department of Oncology, Affiliated Xuzhou Central Hospital, Southeast University, Xuzhou, Jiangsu 221009, P.R. China William G. Lowrie Department of Chemical and Biomolecular Engineering The Ohio State University Columbus OH 43210 USA; Key Laboratory for Ultrafine Materials of Ministry of Education and Frontiers Science Center for Materiobiology and Dynamic Chemistry East China University of Science and Technology 200237 Shanghai P. R. China College of Chemistry and Chemical Engineering, Central South University, Changsha, Hunan, 410083, PR China. Department of Radiology, West China Hospital of Sichuan University, Chengdu, China. Department of Tumor Etiology and Screening, Cancer Institute and General Surgery, The First Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China Department of Cardiopulmonary Bypass; State Key Laboratory of Cardiovascular Medicine; Fuwai Hospital; National Center for Cardiovascular Disease; Chinese Academy of Medical Science and Peking Union Medical College; Beijing China Tumor Etiology and Screening Department of Cancer Institute and General Surgery, The First Affiliated Hospital of China Medical University, and Key Laboratory of Cancer Etiology and Prevention (China Medical University), Liaoning Provincial Education Department, Shenyang, Liaoning, China Laboratory of Molecular Neuro-Oncology, The Rockefeller University College of Management, Southwest University for Nationalities, Chengdu610041, China Key Laboratory for Ultrafine Materials of Ministry of Education; East China University of Science and Technology; Shanghai 200237; China College of Life Sciences Fujian Agriculture and Forestry University Fuzhou 350002 People's Republic of China; Fujian Institute of Microbiology Fuzhou 350007 People's Republic of China; Mycological Research Center College of Life Sciences Fujian Agriculture and Forestry University Fuzhou 350002 People's Republic of China Institute of Microbiology, School of Ecology and Nature Conservation, Beijing Forestry University, Beijing, China Institute of Neuroscience, Kunming Medical college, Kunming 650031, China. Department of Pharmacy The First Affiliated Hospital of Xinjiang Medical University Urumqi China Department of Medical Oncology & Therapeutics Research, City of Hope Comprehensive Cancer Center, Duarte, California, USA Guangzhou Women and Children’s Medical Center Tianhe District Guangzhou China Department of Radiology State Key Laboratory of Coal Mine Disaster Dynamics and Control, Chongqing University, Chongqing 400044, China; Institute for Advanced Study, Shenzhen University, Shenzhen 518060, China Department of Dermatology, Gansu Provincial Central Hospital, Lanzhou, China; Department of Dermatology, Gansu Provincial Maternity and Child-care Hospital, Lanzhou, China School of Pharmacy, Anhui University of Chinese Medicine Hefei 230012, China State Key Laboratory Breeding Base of Dao-di Herbs,National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences Beijing 100700, China. Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Institute of Aging Research, Guangdong Medical University, Dongguan, China; Dongguan Scientific Research Center, Guangdong Medical University, Guangdong, China Tumor Etiology & Screening Department of Cancer Institute & General Surgery, The First Hospital of China Medical University, Shenyang, 110001, China; Key Laboratory of Cancer Etiology & Prevention in Liaoning Education Department, The First Hospital of China Medical University, Shenyang, 110001, China; Key Laboratory of GI Cancer Etiology & Prevention in Liaoning Province, The First Hospital of China Medical University, Shenyang, 110001, China Key Laboratory of Molecular Epigenetics of MOE, Northeast Normal University, Changchun 130024, China National Medical Center for Major Public Health Events, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan P. R. China Key Laboratory for Ultrafine Materials of Ministry of Education East China University of Science and Technology Meilong Road 130 Shanghai 200237 China The Central Laboratory of Binhu Hospital, The Third Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230061, P.R. China Cancer Biology Research Center (Key Laboratory of the Ministry of Education), Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China Department of Intensive Medicine, Gansu Provincial Hospital, 204 West Donggang Rd, Lanzhou, Gansu Province, 730000, China The University of Texas MD Anderson Cancer Center, 77030, Houston, Texas, USA Center for Biotechnology and Interdisciplinary Studies, ‡Department of Biomedical Engineering, §Rensselaer Nanotechnology Center, ∥Department of Materials Science and Engineering, ⊥Department of Mechanical, Aerospace and Nuclear Engineering, Rensselaer Polytechnic Institute, 110 8th Street, Troy, New York 12180-3590, United States Anhui Provincial Center for Disease Control and Prevention Hefei China; Public Health Research Institute of Anhui Province Hefei Anhui China Intensive Care Unit, People’s Hospital of Gansu Province, Lanzhou, Gansu, China Key Laboratory for Ultrafine Materials of Ministry of Education, East China University of Science and Technology, Shanghai 200237, PR China Department of Medical Oncology and Therapeutic Research, City of Hope Comprehensive Cancer Center, Duarte, California, USA Kidney Disease Center The First Affiliated Hospital College of Medicine Zhejiang University Hangzhou China; Institute of Nephrology Zhejiang University Hangzhou China; Key Laboratory of Kidney Disease Prevention and Control Technology Hangzhou China Department of Pathology, Third Xiangya Hospital, Central South University, Changsha, Hunan, China Center for Craniofacial Molecular Biology, University of Southern California, Los Angeles, CA 90033 Duke University State Key Laboratory of Cancer Biology–Department of Pathology, Xijing Hospital; Department of Internal Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou National Engineering Research Center of Neuromodulation, School of Aerospace Engineering, Tsinghua University, Beijing 100084, China; Precision Medicine and Healthcare Research Center, Tsinghua-Berkeley Shenzhen Institute, Tsinghua University, Shenzhen 518071, China City of Hope National Medical Center Duarte California Key Laboratory of Rubber-Plastics, Ministry of Education & Shandong Provincial Key Laboratory of Rubber-plastics, Qingdao University of Science and Technology, Qingdao 266042, China Outpatient Department of Emergency Science Sichuan Armed Police Corps Hospital Leshan China School of Nursing Yangzhou University Yangzhou China; Department of Nursing Affiliated Hospital of Yangzhou University Yangzhou China Department of Ophthalmology, Zunyi First People's Hospital, The Third Affiliated Hospital of Zunyi Medical University, Zunyi, China; Zunyi Medical University, Zunyi, China School of Artificial Intelligence, OPtics and ElectroNics (iOPEN), Northwestern Polytechnical University, Xi’an, China Department of Applied Chemistry, School of Chemistry and Materials Science, Hefei National Research Center for Physical Sciences at the Microscale, University of Science and Technology of China, Hefei, Anhui 230026, China Department of The Second of Gynecologic Oncology Shaanxi Provincial Cancer Hospital Xi'an Shannxi People's Republic of China The Kidney Disease Center , the First Affiliated Hospital, , 79 Qingchun Rd, Hangzhou, 310003 China; Zhejiang University School of Medicine , the First Affiliated Hospital, , 79 Qingchun Rd, Hangzhou, 310003 China Key Laboratory for Ultrafine Materials of Ministry of Education East China University of Science and Technology Shanghai 200237 P. R. China; School of Material Science and Engineering East China University of Science and Technology Shanghai 200237 P. R. China; Engineering Research Center for Biomedical Materials of the Ministry of Education East China University of Science and Technology Shanghai 200237 P. R. China Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China Chinese Medicine Resource Center,China Academy of Chinese Medical Sciences Beijing 100700,China. Departments of Drug Metabolism and Pharmacokinetics1 and Guangdong Provincial Key Laboratory of Medical Molecular Diagnostic, Institute of Aging Research, Guangdong Medical University, Dongguan Tumor Etiology & Screening Department of Cancer Institute & General Surgery, the First Hospital of China Medical University, Shenyang, Liaoning 110001, PR China; Key Laboratory of Cancer Etiology & Prevention in Liaoning Education Department, the First Hospital of China Medical University, Shenyang, Liaoning 110001, PR China; Key Laboratory of GI Cancer Etiology & Prevention in Liaoning Province, the First Hospital of China Medical University, Shenyang, Liaoning 110001, PR China Tumor Etiology and Screening Department of Cancer Institute and General Surgery, The First Affiliated Hospital of China Medical University, Key Laboratory of Cancer Etiology and Prevention, China Medical University, Liaoning Provincial Education Department, Shenyang 110001, China; National Clinical Research Center for Digestive Diseases, Xi’an 110001, China Key Laboratory of GI Cancer Etiology and Prevention in Liaoning Province, First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China. Affiliated Hospital of Yangzhou University Department of Thyroid and Breast Surgery, Wuhan No. 1 Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022 Hubei Province, China Harbin Institute of Technology Chinese Academy of Sciences Howard Hughes Medical Institute and; Broad Institute of Harvard and MIT, Cambridge, MA 02142;; Department of Molecular and Cellular Biology and Chinese Academy of Sciences, Technical Institute of Physics and Chemistry, Center of Applied Laser, Beijing, China National Medical Center for Major Public Health Events Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan P. R. China Department of Medical Oncology & Molecular Therapeutics, City of Hope Comprehensive Cancer Center and Beckman Research Institute, Duarte, CA, USA Engineering Research Center for Biomaterials of Ministry of Education, East China University of Science and Technology, Shanghai, People’s Republic of China; Key Laboratory for Ultrafine Materials of Ministry of Education, East China University of Science and Technology, Shanghai, People’s Republic of China School of Business Administration, Huaqiao University, Quanzhou 362000, China; Oriental Business Management Research Center, Huaqiao University, Quanzhou 362000, China Department of Teaching and Research, Nanjing Forestry University From the Division of Biomedical Sciences, University of California, Riverside. The State Key Laboratory of Bioreactor Engineering; East China University of Science and Technology; Shanghai; China Department of Dermatology, Xijing Hospital The Fourth Military Medical University Xi'an China Department of Cardiology, Renmin Hospital of Wuhan UniversityWuhan, China; Cardiovascular Research Institute of Wuhan UniversityWuhan, China. Center for AIDS/STD Control and Prevention, Henan Center for Disease Control and Prevention, Zhengzhou 450016, China. Division of Neonatology, Department of Pediatrics, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China College of Pharmaceutical Sciences, Soochow University, Suzhou, 215123, China Tumor Etiology and Screening Department of Cancer Institute and General Surgery, The First Affiliated Hospital of China Medical University, Liaoning Provincial Education Department, Key Laboratory of Cancer Etiology and Prevention, China Medical University, Shenyang, Liaoning, China Frontiers Science Center for Materiobiology and Dynamic Chemistry East China University of Science and Technology Shanghai 200237 P. R. China Engineering Research Centre for Biomedical Materials of Ministry of Education The Key Laboratory for Ultrafine Materials of Ministry of Education School of Material Science and Engineering Frontiers Science Center for Materiobiology and Dynamic Chemistry East China University of Science and Technology Shanghai 200237 China The First Clinical Medical College of Lanzhou University, Lanzhou, Gansu Province, China Department of Pharmaceutical Toxicology, School of Pharmacy, China Medical University, Shenyang, China The State Key Laboratory of Bioreactor Engineering; East China University of Science and Technology; Shanghai 200237; P. R. China; Key Laboratory for Ultrafine Materials of Ministry of Education Cardiovascular Center, Liyuan Hospital Affiliated to Tongji Medical College Huazhong University of Science and Technology Wuhan China Department of Emergency Medicine, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, P.R. China Department of Cardiology West China Hospital Sichuan University Chengdu China

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