http://rdf.ncbi.nlm.nih.gov/pubchem/author/MD5_2a4a1eaf819614d4b05f998d71b0dea4
Outgoing Links
Predicate | Object |
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family-name | Lin Lin Lin |
name | Lin Lin |
given-name | Lin |
organization-name | Centre for Advanced Macromolecular Design (CAMD), School of Chemical Sciences and Engineering, The University of New South Wales, Sydney NSW 2052, Australia, Cooperative Research Centre (CRC) for Polymers, 8 Redwood Drive, Notting Hill Vic 3168, Australia, and School of Materials Science and Engineering, Tianjin University, Tianjin 300072, China Department of Nephrology, Weifang People's Hospital, Weifang, Shandong 261041, P.R. China Email: linlinhsn@aliyun.com. Jilin Provincial Center for Disease Control and Prevention, Changchun 130062, Jilin, China. Department of Obstetrics and Gynecology The Third Affiliated Hospital of Wenzhou Medical University Wenzhou China School of Acupuncture-Moxibustion and Tuina, Shanghai University of Traditional Chinese Medicine Key Research Base of Humanities and Social Sciences of the Ministry of Education, Academy of Psychology and Behavior, Tianjin Normal University, China; Center of Collaborative Innovation for Assessment and Promotion of Mental Health, Tianjin, China Department of Fine Chemicals, East China University of Science & Technology, 130 Meilong Road, Shanghai, China Center for Air Resource Engineering and Science, Clarkson University, Potsdam, New York 13699, United States Department of Chemistry, Key Laboratory of Analytical Sciences College of Chemistry and Chemical Engineering Xiamen University Xiamen China Department of Cell Biology, Key Laboratory of Cell Biology, Ministry of Public Health, and Key Laboratory of Medical Cell Biology, Ministry of Education, School of Life Sciences, China Medical University, Shenyang City 110122, Liaoning Province, China Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 Jilin China Plastic Surgery Hospital, Peking Union Medical College (Drs Pan, Lin, Zhao, Zhuang, and Jiang), and Department of Plastic Surgery, Third Hospital of Chinese Armed Police Force Beijing Corp (Dr Lu), Beijing, China. Division of Human Ontogeny and Childhood Department, Graduate School, Tokyo Medical and Dental University, Japan. Department of Otorhinolaryngology-Head and Neck Surgery, Huashan Hospital of Fudan University, Shanghai 200040, China. Shenzhen Academy of Metrology and Quality Inspection, Shenzhen 518102, People’s Republic of China Department of Otorhinolaryngology-Head and Neck Surgery, Nan Fang Hospital, Southern Medical University, Guangzhou, 510515, China. Department of Radiology, Affiliated Zhongshan Hospital of Dalian University , 6 Jiefang Street, Dalian 116001 , China Department of Animal Production, Henan University of Science and Technology, Luoyang, China Department of Biomedicine, Aarhus University, Aarhus, Denmark College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou 450001, People’s Republic of China Biogen, Cambridge, Massachusetts *Key Laboratory of Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China; Department of Neurology, Second Affiliated Hospital, Harbin Medical University, 246 Xuefu Road, Nangang District, Harbin 150086, China Department of Medical Oncology, Fuzhou General Hospital of Nanjing Military Command, Fuzong Clinical College of Fujian Medical University, Fujian - PR China Department of Obstetrics and Gynecology, The Sixth Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China (mainland) Department of Cell Biology, Key Laboratory of Cell Biology, Ministry of Public Health, and Key Laboratory of Medical Cell Biology, Ministry of Education China Medical University Shenyang Liaoning 110122 China Department of Mathematics, University of California, Berkeley, California 94720, United States; Computational Research Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China; Jilin Biomedical Polymers Engineering Laboratory, Changchun 130022, China The Seven Department, Chinese Academy of Medical Sciences and Peking Union Medical College Plastic Surgery Hospital and Institute, Shijingshan District, Beijing, China Department of Pathology, Institute of Basic Medical Sciences Chinese Academy of Medical Science, School of Basic Medicine Peking Union Medical College, Neuroscience Center Chinese Academy of Medical Sciences Beijing 100005 China Computational Research Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States; Department of Mathematics, University of California, Berkeley, California 94720, United States State Key Laboratory of Marine Environmental Science/College of the Environment and Ecology, Xiamen University, Xiamen 361005, China Department of Mathematics, University of California, Berkeley, CA 94720;; Computational Research Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720 State Key Laboratory of Agrobiotechnology, College of Biological Sciences China Agricultural University Beijing China School of Energy and Environmental Engineering, University of Science and Technology Beijing, Beijing100083, People’s Republic of China State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing, People’s Republic of China; College of Life Science, University of Chinese Academy of Sciences, Beijing, People’s Republic of China Department of Chemistry, Tsinghua University, Beijing 100084, China. National Cancer Center, National Clinical Research Center for Cancer, Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China Plastic Surgery Hospital, Chinese Academy of Medical Science, Beijing 100144, China. Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA Department of Gynecology and Obstetrics, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China Guangdong Medical University; Key Laboratory of Medical Electronics and Medical Imaging Equipment State Key Laboratory of Nuclear Physics and Technology, Institute of Heavy Ion Physics, School of Physics, Peking University, Beijing, China College of Basic Medical Sciences Shenyang Medical College Shenyang 110034 P. R. China Key Laboratory of Polymer Ecomaterials; Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China Jiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing, China. Department of Oncology, Fuzhou General Hospital of Nanjing Military Command, Fuzhou, Fujian 350025, P.R. China Department of Epidemiology, School of Binzhou Medical College, Yantai 264003, China. Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi; and School of Food & Biological Engineering, Jiangsu University, Zhenjiang 212013, China Yangtze Delta Region Institute (Huzhou) University of Electronic Science and Technology of China Huzhou 313001 P. R. China Department of Biology, Queens College Department of Pathology, Chongqing Medical University, Molecular Medicine and Cancer Research Center, Chongqing 400016, China. Cardiovascular Center, National Taiwan University Hospital, Hsinchu Branch, Hsinchu, Taiwan. State Key laboratory Breeding Base for Sustainable Control of Pest and Disease, Key Laboratory of Biotechnology in Plant Protection, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, PR China Department of Medical Oncology, The First Affiliated Hospital of USTC, Division of Life Science and Medicine, University of Science and Technology of China, Hefei, China Department of Gynecology and Obstetrics, First Hospital of Harbin Medical University, Harbin, China Department of Cardiology, The First Affiliated Hospital of Shandong First Medical University, Jinan, China Department of Anaesthesiology The First Affiliated Hospital Sun Yat‐sen University Guangzhou China Department of Clinical Laboratory, First Affiliated Hospital of Dalian Medical University, Dalian, China. Department of Gastroenterology, Qilu Hospital of Shandong University, Jinan 250012, China Department of Obstetrics and Gynecology, First Hospital of Qinhuangdao, Qinhuangdao, Hebei, China (mainland) Department of Gastroenterology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China Department of Learning Technologies, University of North Texas, 3940 North Elm Street, G150, Denton, TX 76207 Department of Gastroenterology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China UCL Institute of Child Health and Department of Medicine (L.L., W.S.T., J.C.A.), University College London, London WC1N 1EH, United Kingdom Department of Gastroenterology Peking University Third Hospital Beijing China Department of Medical Oncology, Fujian Provincial Cancer Hospital, the Teaching Hospital of Fujian Medical University, the Teaching Hospital of Fujian University of Traditional Chinese Medicine, Fuzhou 350014, China Shanghai University of Medicine and Health Sciences, Shanghai 200093, People’s Republic of China; Research Laboratory for Functional Nanomaterial, National Engineering Research Center for Nanotechnology, Shanghai 200241, People’s Republic of China Medarex Inc, Bloomsbury, NY, USA. Beijing Normal University Department of Surgery and Oncology, Shenzhen Second People's Hospital/First Affiliated Hospital to Shenzhen University Department of Obstetrics and Gynecology Key Laboratory for Major Obstetric Diseases of Guangdong Province The Third Affiliated Hospital of Guangzhou Medical University Guangzhou China Beth Israel Deaconess Medical Center Harvard Medical School Boston MA USA School of Energy and Environmental Engineering, University of Science and Technology Beijing, Beijing 100083, China; Beijing Engineering Research Center of Energy Saving and Environmental Protection, Beijing 100083, China Eye Center, Affiliated Second Hospital, School of Medicine Zhejiang University Hangzhou China From the Department of Hematopathology, The University of Texas M. D. Anderson Cancer Center, Houston. From the Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College. Department of Gastroenterology Jiangsu Province Hospital Nanjing China The First Affiliated Hospital of Nanjing Medical University, Nanjing The State Key Laboratory Breeding Base for Sustainable Control of Pest and Disease, China Key Laboratory of Biotechnology in Plant Protection of MOA of China and Zhejiang Province Institute of Virology and Biotechnology Zhejiang Academy of Agricultural Sciences Hangzhou 310021 China; Institute of Plant Virology Ningbo University Ningbo 315211 China Department of Respiratory Diseases, Sun Yat-sen Memorial Hospital, Sun Yat-Sen University Guangzhou 510120, China. Department of Radiology, Fujian Medical University Union Hospital, Fuzhou, 350001, P. R. China Department of Gastroenterology and Hepatology Tianjin Medical University General Hospital Tianjin China; Tianjin Institute of Digestive Disease Tianjin Medical University General Hospital Tianjin China State Key Laboratory of Oral Diseases West China Hospital of Stomatology Sichuan University Chengdu China Department of Cardiology, The Second Affiliated Hospital of Xi’an Jiaotong University, Shaanxi, People’s Republic of China BGI Ark Biotechnology Co., LTD (BAB), Shenzhen, Guangdong, China.; Department of Biomedicine, University of Aarhus, Aarhus C, Denmark. Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing Key Laboratory of Clinical Study on Anticancer Molecular Targeted Drugs Beijing China Shanghai National Clinical Research Center for Metabolic Diseases Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Institute of Endocrine and Metabolic Diseases Shanghai China Department of Biomedicine, Aarhus University, 8000 Aarhus, Denmark Department of Prevention and Health Care, Third Hospital of Guangzhou Medical University, Guangzhou 510150, China. Central Laboratory, The First Affiliated Hospital Xiamen University Xiamen China Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan 48109, United States Department of Gastroenterology Changzheng Hospital Second Military Medical University Shanghai China Institute of Sports Medicine, Peking University Third Hospital, Beijing, China †Key Laboratory of Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China; and Sustech Core Research Facilities, Southern University of Science and Technology, Shenzhen, 518055, China Department of Biomedicine, Aarhus University, Aarhus 8000, Denmark; Steno Diabetes Center Aarhus, Aarhus University Hospital, Aarhus 8200, Denmark Section of Thoracic Surgery, Department of Surgery, University of Michigan, Ann Arbor, MI, USA Department of General Medicine, Second Affiliated Hospital of Harbin Medical University, Harbin, China State Key Laboratory for Urban and Regional Ecology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, P.O. Box 2871, Beijing 100085, China Princeton University 2 Program in Applied and Computational Mathematics, , Princeton, New Jersey 08544, USA Department of Otorhinolaryngology Head and Neck Surgery, Fourth Affiliated Hospital, Guangxi Medical University, Liuzhou, 545005, China. University of Occupational and Environmental Health Japan Kitakyushu Japan College of Pharmacy and State Key Laboratory of Element-Organic Chemistry, Nankai University, Tianjin 300071, China. Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China. Beth Israel Deaconess Medical Center; Harvard Medical School; Boston; USA Fujian Medical University Department of Medical Oncology Fuzhou China Department of Cell Biology and Molecular Medicine, Cardiovascular Research Institute, University of Medicine and Dentistry of New Jersey-New Jersey Medical School, Newark, New Jersey; and Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China Innovation Research Institute of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, Shandong 250355, China Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing, China. University of Maine Department of Mechanical Engineering, , Orono, Maine 04469 Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 China; Jilin Biomedical Polymers Engineering Laboratory Changchun 130022 China Department of Cell Biology Key laboratory of Cell Biology Ministry of Public Health China Medical University Shenyang China; Key laboratory of Medical Cell Biology Ministry of Education School of Life Sciences China Medical University Shenyang China Department of Surgery The Fourth Affiliated Hospital, China Medical University Shenyang China Department of Obstetrics and Gynecology Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Science Beijing People's Republic of China; Department of Obstetrics and Gynecology The Maternal & Child Health Hospital of Guangxi Zhuang Autonomous Region Guangxi People's Republic of China Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China 510120, China Department of Obstetrics and Gynecology, West China Second Hospital, Sichuan University, Chengdu 610041, China. Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China; University of Science and Technology of China, Hefei 230026, China; Jilin Biomedical Polymers Engineering Laboratory, Changchun 130022, China School of Life Science and Technology, ShanghaiTech University , Shanghai 201210 , China Institute of Dermatology Chinese Academy of Medical Sciences Nanjing China Institute of Sports Medicine, Peking University Third Hospital, Haidian District, Beijing, China Fourth Affiliated Hospital , Xinjiang Medical University, Urumqi, Xinjiang, Uganda Key Laboratory of Chem-Biosensing; Anhui province; Key Laboratory of Functional Molecular Solids; Anhui province; College of Chemistry and Materials Science; Center for Nano Science and Technology; Anhui Normal University a Exposure Science Division, Environmental and Occupational Health Sciences Institute , Piscataway , NJ , USA School of Agricultural Engineering and Food Science, Shandong University of Technology, Zibo 255000, China; Key Laboratory of Wooden Materials Science and Engineering of Jilin Province, Beihua University, Jilin 132013, China Department of Statistics , The Pennsylvania State University, University Park, PA 16802, USA Lin Lin and John C. Achermann are form the Genetics & Genomic Medicine University College London (UCL) Great Ormond Street Institute of Child Health, University College London London United Kingdom Department of Thoracic Surgery, West China Hospital, Sichuan University, 37 Guoxue Alley, Chengdu 610041, China; West China School of Nursing, Sichuan University, 37 Guoxue Alley, Chengdu 610041, China Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China; Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumors, State Key Laboratory of Medical Genomics, Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China Department of Medical Oncology,Cancer Hospital/Institute,Chinese Academy of Medical Sciences &PUMC,Beijing 100021,P.R.China. The Key Laboratory for Chemical Biology of Fujian Province and Key Laboratory of Analytical Science of Xiamen University, College of Chemistry and Chemical Engineering, State Key Laboratory of Marine Environmental Science, and Department of Mechanical and Electrical Engineering, Xiamen University, Xiamen 361005, China Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing Key Laboratory of Clinical Study on Anticancer Molecular Targeted Drugs, Beijing, 100021, PR China School of Mechatronics Engineering, Harbin Institute of Technology, Harbin 150001, China Pediatric Clinical Pharmacology Laboratory Shanghai Children's Medical Center School of Medicine Shanghai Jiao Tong University Shanghai China; Department of Anesthesiology Shanghai Children's Medical Center School of Medicine Shanghai Jiao Tong University Shanghai China Key Laboratory of the Ministry of Education for Coastal and Wetland Ecosystems/College of the Environment & Ecology, Xiamen University, Xiamen361102, China Department of Biomedicine, Aarhus University, Aarhus, Denmark; Danish Regenerative Engineering Alliance for Medicine, Department of Biomedicine, Aarhus University, Aarhus, Denmark 1Department of Biological Sciences and Max Planck Research Group “Prokaryotic Cell Biology”, Max Planck Institute for Terrestrial Microbiology Marburg Germany; Faculty of Biology Philipps‐Universität Marburg Germany Department of Gastroenterology, Shanghai Changzheng Hospital, Second Military Medical University, 415 Fengyang Road, Shanghai 200003, China Department of Gastrointestinal Surgery, Second Hospital of Hebei Medical University, Shijiazhuang, China. Department of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, China Authors' Affiliations: 1Section of Thoracic Surgery, Department of Surgery and 2Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan and 3Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School and The Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts South China Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Guangzhou, China Key Laboratory of the Ministry of Education for Coastal and Wetland Ecosystems/College of the Environment & Ecology, Xiamen University, Xiamen 361102, China Central South University, China Department of Gastroenterology, The First Affiliated Hospital of Nanjing Medical University, Nanjing Department of Gynecology and Obstetrics, Wenzhou Hospital of Traditional Chinese Medicine, Wenzhou, China Department of Medical and Molecular Genetics, Walther Oncology Center, Indiana University School of Medicine and the Walther Cancer Institute, Indianapolis, IN 46202, U.S.A. National Cancer Center/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China Longgang District Center for Disease Control and Prevention Shenzhen China State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China; Ministry of Science and Technology International Research Center for Animal Disease, The Cooperative Innovation Center for Sustainable Pig Production, Huazhong Agricultural University, Wuhan, China Department of Nuclear Medicine, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China Department of Chemistry, National Dong Hwa University, Shoufeng, Hualien 974, Taiwan State Key Laboratory of Medical Genomics, Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health, National Clinical Research Center for Metabolic Diseases, Collaborative Innovation Center of Systems Biomedicine, Shanghai Jiao‐Tong University School of Medicine, Shanghai, China; Shanghai Clinical Center for Endocrine and Metabolic Diseases, Rui‐Jin Hospital, Shanghai Jiao‐Tong University School of Medicine, Shanghai, China Department of Forensic Sciences, School of Basic Medicine, Central South University, Changsha, Hunan, China and Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China; University of Science and Technology of China, Hefei 230026, P. R. China; Jilin Biomedical Polymers Engineering Laboratory, Changchun 130022, P. R. China Department of Chemistry and Chemical Engineering; Changchun University of Science and Technology; Changchun 130022, P. R. China Division of Gastroenterology the First Affiliated Hospital of Nanjing Medical University Nanjing China Biogen Cambridge Massachusetts USA Department of Cardiology Guangzhou Liuhuaqiao Hospital Guangzhou China Avic Jonhon Optronic Technology Co., Ltd. Key Laboratory of polymer Ecomaterials Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 China Department of Obstetrics Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei Province China 1Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Bio-X Institutes, Shanghai Jiao Tong University, Shanghai, China Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 P. R. China; Jilin Biomedical Polymers Engineering Laboratory Changchun 130022 P. R. China The Key Laboratory of Pathobiology, Ministry of Education, College of Basic Medical Sciences, Jilin University, Changchun 130021, China Zhejiang Academy of Medical Sciences, Hangzhou Medical College, Hangzhou, China Division of Gastroenterology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China Department of Obstetrics and Gynecology, Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, Nanning, China Department of Anatomy and Neurobiology, University of California, Irvine, California, USA. National Clinical Research Center for Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases Ruijin Hospital, Shanghai Jiao Tong University School of Medicine Shanghai China Department of Mathematics, University of California 1 , Berkeley, California 94720, USA; Computational Research Division, Lawrence Berkeley National Laboratory 2 , Berkeley, California 94720, USA National Clinical Research Center for Metabolic Diseases, Rui Jin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China Department of Laboratory Medicine, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University Key Laboratory of South China Sea Fishery Resources Exploitation and Utilization, Ministry of Agriculture and Rural Affairs, South China Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Guangzhou 510300, China; Scientific Observation and Research Station of Xisha Island Reef Fishery Ecosystem of Hainan Province, Key Laboratory of Efficient Utilization and Processing of Marine Fishery Resources of Hainan Province, Sanya Tropical Fisheries Research Institute, Sanya 572018, China; Guangdong Provincial Key Laboratory of Fishery Ecology Environment, Guangzhou 510300, China; Observation and Research Station of Pearl River Estuary Ecosystem, Guangzhou 510300, China Department of Oral Mucosa Diseases, Nanjing Stomatological Hospital, Medical School of Nanjing University, No 30 Zhongyang Road, Nanjing 210008, China The State Key Laboratory Breeding Base for Sustainable Control of Pest and Disease, Key Laboratory of Biotechnology in Plant Protection of MOA of China and Zhejiang Province, Institute of Virology and Biotechnology Zhejiang Academy of Agricultural Sciences Hangzhou 310021 China Sun Yat‐sen Memorial Hospital Sun Yat‐sen University Guangzhou China Institute of Plant Virology Ningbo University Ningbo 315211 China State Key Laboratory of Molecular Biology, Shanghai Science Research Center, Chinese Academy of Sciences Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China; Chromatin Biology Laboratory, Key Laboratory of Cell Biology, Ministry of Public Health of China, China Medical University, China Department of Biomedicine, Aarhus University, 8000 Aarhus, Denmark; Steno Diabetes Center Aarhus, Aarhus University Hospital, 8200 Aarhus, Denmark Institute of Biomedical Engineering, College of Medicine and College of Engineering, National Taiwan University, Taipei, Taiwan. University College London Institute of Child Health (L.L., M.T.D., J.C.A.), University College London, London WC1N 1EH, United Kingdom; the Department of Medicine (L.L., J.C.A.), University College London, London WC1N 1EH, United Kingdom Population Genetics and Embryology, Institute of Genetics and Biotechnology, University of Aarhus, Tjele, Denmark.; Institute of Human Genetics, University of Aarhus, Aarhus, Denmark.; Beijing Genomics Institute, Beijing, People's Republic of China. Vaccine and Infectious Disease Division Fred Hutchinson Cancer Research Center Seattle Washington School of Food & Biological Engineering Jiangsu University Zhenjiang 212013 China Developmental Endocrinology Research Group, UCL Institute of Child Health Computational Research Division; Lawrence Berkeley National Laboratory; Berkeley; USA; Department of Mathematics Department of Gastroenterology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China Department of Biological Sciences, Sam Houston State University, Huntsville, Texas 77341 Eye Center, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China; Eye Hospital, Zhejiang University, Hangzhou 310009, China Department of Chemistry, Southern University of Science and Technology, Shenzhen 518055, China Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 P. R. China Department of Radiation Oncology, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghafi, China Department of Medical Oncology, Cancer Institute/Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College; Beijing Key Laboratory of Clinical Study on Anticancer Molecular Targeted Drugs, Beijing 100021, China. Department of Physiology and Biophysics, State University of New York at Buffalo, School of Medicine and Biomedical Sciences, Buffalo, NY, USA Department of Respiration, Guangzhou Women and Children’s Medical Centre, Guangzhou Medical University, Guangzhou 510120, Guangdong, China Bio-X Institutes Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders Ministry of Education Shanghai Jiao Tong University Shanghai 200240 China School of Biotechnology and Food Engineering, Hefei University of Technology, Hefei, China. Division of Nephrology, Department of medicine 5th Affiliated Hospital of Sun Yat‐Sen University Zhuhai China School of Chemical and Environmental Engineering, Shanghai Institute of Technology, Shanghai, 201418, PR China Department of Medical Oncology National Cancer Center, National Clinical Research Center for Cancer, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China grid.13291.38 0000000108071581 Chemical Engineering Institute Sichuan University 610065 Chengdu China Department of Information Center, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China Spotlab , P.º de Juan XXIII, 36B, Madrid 28040 , Spain; Biomedical Image Technologies Laboratory, ETSI Telecomunicación, Universidad Politécnica de Madrid , Av. Complutense, 30, Madrid 28040 , Spain State Key Laboratory of Agricultural Microbiology, The Cooperative Innovation Center for Sustainable Pig Production, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China Sports Medicine Department, Beijing Key Laboratory of Sports Injuries, Peking University Third Hospital, Beijing, China; Institute of Sports Medicine of Peking University, Beijing, China Department of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China; Chinese Glioma Cooperative Group (CGCG), Beijing 100050, China UCL Institute of Child Health (L.L., J.C.A.), University College London, London WC1N 1EH, United Kingdom State Key Laboratory of Electronic Thin Films and Integrated Devices, School of Integrated Circuit Science and Engineering, University of Electronic Science and Technology of China, Chengdu 610054, P. R. China Stem Cell and Developmental Biology Group, Genome Institute of Singapore, A*STAR, Singapore 138672, Singapore.; National University of Singapore (NUS) Graduate School for Integrative Sciences and Engineering, NUS, Singapore 117456, Singapore. Department of Gynecology and Obstetrics, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, PR China Department of Gastroenterology Tianjin Medical University General Hospital Airport Hospital Tianjin China Department of Clinical Laboratory The First Affiliated Hospital of Dalian Medical University Dalian China Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor—University of California at Los Angeles (UCLA) Medical Center, 1124 West Carson St., Torrance, California 90502 Clinical Pharmacology and Pharmacometrics Biogen Cambridge Massachusetts USA Second Department of Gynecology, The Second Hospital of Dalian Medical University, Dalian, China National Key Laboratory of Plant Molecular Genetics, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200032, China; Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 China School of Laboratory Medicine, Chengdu Medical College, China; Sichuan Provincial Engineering Laboratory for Prevention and Control Technology of Veterinary Drug Residue in Animal-origin Food, Chengdu Medical College, China Division of Gastroenterology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China; Department of Genetics and Biotechnology, Aarhus University, Tjele, Denmark.; Institute of Human Genetics, Aarhus University, Aarhus, Denmark.; BGI/HuaDa Shenzhen, Shenzhen, People's Republic of China. Division of Gastroenterology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China From the Department of Physiology and Biophysics (Y.F., J.E.H., D.L., L.L., R.D.M., L.C., L.A.J., R.L.) and Division of Nephrology, Department of Medicine (L.A.J., R.L.), University of Mississippi Medical Center, Jackson, MS; Research Service (C.E.G.-S.), G.V. (Sonny) Montgomery Veterans' Affairs Medical Center, Jackson, MS. Department of Clinical Laboratory, Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, Henan 450008, P.R. China Department of Medical Oncology, Cancer Hospital (Institute), Chinese Academy of Medical Science, Peking Union Medical College Beijing 100021, China. Department of Cardiology, The 2nd Affiliated Hospital of Harbin Medical University, Harbin, China; The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, 246 Xuefu Road, Nangang District, 150086 Harbin, China Department of Family Health School of Nursing The University of Texas Health Science Center at Houston Houston Texas State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products, Institute of Plant Virology, Ningbo University, Ningbo, China Department of Gastroenterology, The First Affiliated Hospital of Nanjing Medical University and Zhejiang University Hospital, Zhejiang University, Hangzhou, Zhejiang, China State Key Laboratory of Marine Environmental Science College of the Environment and Ecology Xiamen University Xiamen 361102 China Department of Medical Oncology Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital Fuzhou China Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California Division of Biomedical Sciences, University of California, Riverside, Riverside, CA 92521, USA Department of Biomedicine, Aarhus University, 8000 Aarhus, Denmark; China National GeneBank, BGI-Shenzhen, 518083 Shenzhen, China b Center for Air Resource Engineering and Science, Clarkson University , Potsdam , NY , USA The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510120, China Department of Operation, First Affiliated Hospital of Fujian Medical University, Fuzhou, China Changzhou CDC, No. 203, Taishan Road, Changzhou, Jiangsu, China Department of Cell Biology, Key laboratory of Cell Biology, Ministry of Public Health, and Key laboratory of Medical Cell Biology, Ministry of Education, China Medical University, Shenyang, Liaoning 110122, China Food Testing Institute, Shenzhen Academy of Metrology & Quality Inspection, Shenzhen, Guangdong 518131, PR China Formerly, Applied BioMath, Inc. Concord Massachusetts USA Obstetrics and Gynecology Department West China Second University Hospital, Sichuan University Chengdu China College of Physics and Energy, Fujian Normal University, Fujian Provincial Key Laboratory of Quantum Manipulation and New Energy Materials, Fuzhou 350117, China; Fujian Provincial Engineering Technology Research Center of Solar Energy Conversion and Energy Storage, Fuzhou 350117, China; Fujian Provincial Collaborative Innovation Center for Optoelectronic Semiconductors and Efficient Devices, Xiamen 361005, China Prokaryotic Cell Biology Group, Max Planck Institute for Terrestrial Microbiology, 35043 Marburg, Germany;; Faculty of Biology and School of Life and Environmental Sciences, Wenzhou University, Wenzhou 325035, China Department of Gastroenterology and Hepatology, Tianjin Medical University General Hospital, Tianjin, China;; Tianjin Institute of Digestive Disease, Tianjin Medical University General Hospital, Tianjin, China Department of Ultrasound, The First Medical Center of Chinese PLA General Hospital, Beijing, China Department of Gastroenterology, the First Affiliated Hospital of Nanjing Medical University, 300# Guangzhou Road, Gulou District, Nanjing, 210029, China State Key Laboratory of Marine Environmental Science/Environmental Science Research Center, Xiamen University, Xiamen 361005, China Division of Gastroenterology, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, China Department of Otorhinolaryngology Head and Neck Surgery,Huashan Hospital North of Fudan University,Shanghai,201907,China. Department of Ultrasound Ganzhou People's Hospital Ganzhou China Department of Ultrasound, First Medical Center Chinese PLA General Hospital Beijing China Department of Pediatrics, Montefiore St. Luke's Cornwall Hospital, Newburgh, New York Plastic Surgery Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China Department of Biological Sciences, Sam Houston State University, Huntsville, TX 77341, USA. Department of Neurosurgery, The Fourth Affiliated Hospital of Xinjiang Medical University Urumqi, 830000, P.R. China. School of Landscape and Architecture, Zhejiang A & F University, Hangzhou, China; Zhejiang Provincial Key Laboratory of Germplasm Innovation and Utilization for Garden Plants, Zhejiang A & F University, Hangzhou, China; Key Laboratory of National Forestry and Grassland Administration on Germplasm Innovation and Utilization for Southern Garden Plants, Zhejiang A & F University, Hangzhou, China College of Plant Protection Nanjing Agricultural University Nanjing 210095 China Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China.; University of Science and Technology of China, Hefei 230026, China.; Jilin Biomedical Polymers Engineering Laboratory, Changchun 130022, China. 1Department of Urology, University of California, Los Angeles, Los Angeles, California. Department of Medicine Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation and Tzu Chi University Hualien Taiwan Department of Radiology, Fujian Medical University Union Hospital, Fuzhou 350001, China Department of Nephrology, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, China; Guangdong Provincial Key Laboratory of Biomedical Imaging, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, China Department of Dermatology Southwest Hospital Third Military Medical University Chongqing 400038 China Department of Gastroenterology, The First Affiliated Hospital of Nanjing Medical University People’s Hospital of Jiangsu Province, China State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro‐products Key Laboratory of Biotechnology in Plant Protection of MOA and Zhejiang Province Zhejiang Academy of Agricultural Sciences Hangzhou 310021 China; Institute of Plant Virology Ningbo University Ningbo 315211 China Department of Hematology, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, People’s Republic of China Key Laboratory of South China Sea Fishery Resources Exploitation & Utilization, Ministry of Agriculture and Rural Affairs, Guangdong Provincial Key Laboratory of Fishery Ecology and Environment, South China Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Guangzhou, China; Observation and Research Station of Pearl River Estuary Ecosystem, Guangzhou, China From the Department of Neurology and Institute of Neurology of First Affiliated Hospital (F.Z., L.Q., L.C., Y.Z., Xiaodan Lin, J.H., Xin Lin, Q.H., Yuhua Lin, L.L., L.W., F.L., K.Y., M.L., Yi Lin, Y.F., N.W., Z.W.), Institute of Neuroscience, Fujian Key Laboratory of Molecular Neurology, Fujian Medical University, Fuzhou; and Department of Neurology (L.Q., Xin Lin, F.L., M.L., Yi Lin, Y.F., N.W., Z.W.), National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical... College of Life Science, Shandong Agricultural University, Tai’an 271018, China Anxi College of Tea Science, Fujian Agriculture and Forestry University , Anxi 362406 , China State Key Laboratory of Marine Environmental Science/College of the Environment and Ecology, Xiamen University, Xiamen, China; Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai), Sun Yat-Sen University, Zhuhai, China Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai 200240, China Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry Chinese Academy of Sciences, Changchun 130022, China; Jilin Biomedical Polymers Engineering Laboratory, Changchun 130022, China Department of Anesthesiology, Shanghai Children’s Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Materials Characterization & Preparation Center; Southern University of Science and Technology; Shenzhen 518055; China Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts 02115, United States Department of Dermatology Buffalo Medical Group Williamsville NY USA State Key Laboratory of Medical Genomics, Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health, National Clinical Research Center for Metabolic Diseases, Collaborative Innovation Center of Systems Biomedicine, and Shanghai Clinical Center for Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Department of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China Department of Otorhinolaryngology Head and Neck Surgery, Institute of Otorhinolaryngology, General Hospital of Chinese People's Liberation Army, Beijing 100853, China. Health Examination Department, Affiliated Qingdao Hiser Hospital of Qingdao University, Qingdao, Shandong 266000, P.R. China Los Angeles Biomedical Research Institute, Torrance, California, USA Cancer Institute & Hospital, PUMC & CAMS of China, 100021 Beijing, China Prokaryotic Cell Biology Group, Max Planck Institute for Terrestrial Microbiology, 35043 Marburg, Germany.; Faculty of Biology, Philipps-Universität, 35043 Marburg, Germany. Institute for the Study of Liver Diseases, The Third People's Hospital of Changzhou, Changzhou, Jiangsu 213000, P.R. China Department of Mathematics, University of California, Berkeley, Berkeley, California, United States; Computational Research Division, Lawrence Berkeley National Laboratory, Berkeley, California, United States Departments of Pathology and Laboratory Medicine, and Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Renmin Street 5625, Changchun 130022, China Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China Department of Family Health, The University of Texas Health Science Center at Houston, School of Nursing, Houston, Texas (J.E.C., L.L., T.S.A.); Department of Neuro-Oncology, The University of Texas MD Anderson Cancer Center,Houston, Texas (T.S.A., A.A.A., E.V.B., M.R.G.); Department of Nursing Systems, The University of Texas Health Science Center at Houston,School of Nursing, Houston, Texas (G. School of Educational Sciences, Harbin Normal University, Harbin, P.R. China; School of Marxism, Harbin Normal University, Harbin, P.R. China Division of Gastroenterology The First Affiliated Hospital of Nanjing Medical University Nanjing China Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University , Shanghai 200240, China Department of Dermatology The Fifth Affiliated Hospital, Southern Medical University Guangzhou China; School of Basic Medical Sciences, Department of Immunology Southern Medical University Guangzhou China Department of Neurosurgery, Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China; Chinese Glioma Cooperative Group (CGCG), Beijing 100050, China Department of Biomedicine, Faculty of Heath, Aarhus University, Aarhus, Denmark College of Medicine, National Taiwan University, Taipei, Taiwan; Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Canada Department of Physiology and Biophysics, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY, USA Department of Gastroenterology, the First Affiliated Hospital with Nanjing Medical University, Nanjing, China School of Chemical and Environmental Engineering, Shanghai Institute of Technology, Shanghai 201418, China; Research Laboratory for Functional Nanomaterial, National Engineering Research Center for Nanotechnology, Shanghai 200241, China CAS Key Laboratory of Nanosystem and Hierarchical Fabrication; CAS Center for Excellence in Nanoscience; National Center for Nanoscience and Technology; Beijing 100190; China Shanghai National Clinical Research Center for Metabolic Diseases Rui Jin Hospital Shanghai Jiao Tong University School of Medicine Shanghai Institute of Endocrine and Metabolic Diseases Shanghai China; Department of endocrine and metabolic diseases Rui Jin North Hospital Shanghai Jiao Tong University School of Medicine Shanghai China Department of Clinical Laboratory, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China Department of Gynecology and Obstetrics Obstetrics and Gynecology Hospital, Fudan University Shanghai China Department of Medicine Hualien Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation and Tzu Chi University Hualien Taiwan Departments of Surgery, Radiology, Pathology, and Radiation Oncology, University of Michigan, Ann Arbor, MI 48109 Institute of Genetics, Linyi People's Hospital, Linyi, Shandong 276000, China. lilinxy1996@sina.com. Department of Medicine, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation and Tzu Chi University, Hualien, Taiwan; Department of Surgery, Department of Gastrointestinal Surgery, The Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong 524000, P.R. China Xiangya Nursing School of Central South University; Guangdong Medical University Center for Epigenomics, University of California San Diego, School of Medicine, La Jolla, CA 92093, USA. Department of Biochemistry and Molecular Biology, Division of Nephrology, and the Indiana Center for Biological Microscopy, Indiana University School of Medicine, Indianapolis, Indiana 46202 Department of Obstetrics and Gynaecology, Shenyang Women’s and Children’s Hospital, Shenyang, China Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Science, Changchun 130022, P. R. China Department of Gastroenterology, The First Affiliated Hospital with Nanjing Medical University, Nanjing 210029, Jiangsu Province, China Department of Sports Medicine, Peking University Third Hospital, Institute of Sports Medicine of Peking University, Beijing Key Laboratory of Sports Injuries, Beijing, China. Laboratory of Polymer Ecomaterials; Changchun Institute of Applied Chemistry; Chinese Academy of Sciences; Changchun; China Department of Pathology, University of California Los Angeles, Los Angeles, California, USA College of Material Science and Engineering; College of Chemical and Environmental Engineering; Harbin University of Science and Technology; Harbin 150080; People's Republic of China MediChem Research, Inc., 12305 South New Avenue, Lemont, Illinois 60439, Program for Collaborative Research in the Pharmaceutical Sciences, Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, 833 South Wood Street, Chicago, Illinois 60612, and ABL-Basic Research Program, NCI-Frederick Cancer Research and Development Center, Frederick, Maryland 21702 Key Laboratory of Polymer Ecomaterials; Changchun Institute of Applied Chemistry; Chinese Academy of Sciences; Changchun 130022; China Department of Radiology Fujian Medical University Union Hospital Fujian Medical University Fuzhou China Department of Gastroenterology,Tianjin Medical University General Hospital Airport Hospital,Tianjin Airport Economic Area,Tianjin,China Department of Gastroenterology First Affiliated Hospital of Nanjing Medical University Nanjing China Department of Pharmacology, School of Medicine, Southeast University, Nanjing, China. Applied BioMath, Lincoln Massachusetts USA Department of Otorhinolaryngology—Head and Neck Surgery, Huashan Hospital of Fudan University, Shanghai, China Hangzhou Aeronautical Sanatorium of Chinese Air Force, Hangzhou, China. Authors' Affiliations: 1Section of Thoracic Surgery, Department of Surgery, 2Division of Medical Oncology, Department of Medicine, 3Biostatistics Unit, Comprehensive Cancer Center, 4Department of Pharmacology, School of Medicine, 5Division of Pulmonary Medicine, Department of Medicine, and 6Department of Pathology, University of Michigan; and 7Veterans Administration Ann Arbor Healthcare System, Ann Arbor, Michigan Sports Medicine Department, Beijing Key Laboratory of Sports Injuries, Peking University Third Hospital, Beijing 100191, China College of Grassland Agriculture Northwest A&F University Yangling Shaanxi 712 100 P. R. China China-Australia Joint Research Center for Functional Molecular Materials School of Chemical Science and Engineering Tongji University Shanghai 200092 China Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai, China Cleveland Clinic Foundation, Cleveland Clinic, Cleveland, Ohio Institute for the Study of Liver Diseases; Department of Pharmacy, The Third People's Hospital of Changzhou, Changzhou, Jiangsu, China. National Laboratory of Solid State Microstructures, College of Engineering and Applied Sciences, Jiangsu Key Laboratory of Artificial Functional Materials, Collaborative Innovation Center of Advanced Microstructures, Nanjing University, Nanjing 210093, China BGI Ark Biotechnology Co., LTD (BAB), Shenzhen, China.; Department of Biomedicine, Aarhus University, Aarhus, Denmark. Department of Chemistry, Tongji University, Shanghai 200092, China Key Laboratory of Functional and Clinical Translational Medicine, Department of Microbiology and Immunology Xiamen Medical College Xiamen 361023 China Department of Clinical Laboratory First Affiliated Hospital of Dalian Medical University Dalian China Department of Auricular Reconstruction, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College State Key Laboratory of Marine Environmental Science/College of the Environment and Ecology Xiamen University Xiamen P. R. China State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Medical College of Soochow University, Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions, School for Radiological and Interdisciplinary Sciences (RAD‐X) Jiangsu Provincial Key Laboratory of Radiation Medicine and Protection Suzhou P. R. China Department of Gastroenterology, Tianjin Medical University General Hospital Airport Hospital, Tianjin, China Shandong University of Traditional Chinese Medicine, 250003 Ji-nan, China Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill , Chapel Hill, NC , USA Department of Clinical Laboratory, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, P.R. China University of North Texas Department of Gastroenterology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine China. The Fourth Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu, China (mainland) Department of Molecular and Integrative Physiology, University of Michigan-Ann Arbor National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention Beijing 100052, China. HIV/AIDS Control and Prevention, Key Laboratory of Infectious Disease Control and Prevention, Shandong Center for Disease Control and Prevention Jinan 250014, Shandong, China. Academy of Preventive Medicine, Shandong University Jinan 250014, Shandong, China. Department of Surgery, University of Michigan, Ann Arbor, MI, USA Department of Statistics, The Pennsylvania State University, University Park, PA, USA, 16802 Department of Surgery, The First Affiliated Hospital, Fujian Medical University, Fuzhou 350005, China Department of Medicine, Hualien Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation and Tzu Chi University Hualien Taiwan Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China Developmental Endocrinology Research Group (B.F.-d.-S., R.E.H.-D., L.L., J.C.A.), University College London Institute of Child Health, University College London, London WC1N 1EH, United Kingdom Department of Dermatology Zhujiang Hospital Southern Medical University Guangzhou China; Department of Immunology School of Basic Medical Sciences Southern Medical University Guangzhou China Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China; Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, State Key Laboratory of Medical Genomics, Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China †Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109; Department of Cardiology, Key Laboratories of Education Ministry for Myocardial Ischemia Mechanism and Treatment, 2nd Affiliated Hospital of Harbin Medical University, Harbin 150086, China Department of Biomedicine Aarhus University Aarhus C Denmark Plastic Surgery Hospital, Chinese Academy of Medical Science and Peking Union Medical College Environmental Science and New Energy Technology Research Center, Tsinghua-Berkeley Shenzhen Institute, Tsinghua University, Shenzhen 518055, China School of Food & Biological Engineering; Jiangsu University; Zhenjiang 212013; P. R. China; Interdisciplinary Nanoscience Center Zhejiang University Hospital, Hangzhou 310058, China; Email: linlinbaiyitianshi@163.com. Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China; University of Chinese Academy of Sciences, Beijing 100049, China Richardson Centre for Functional Foods and Nutraceuticals, Department of Human Nutritional Sciences, 196 Innovation Drive, University of Manitoba, Winnipeg, MB R3T 2N2, Canada. Fuqing City Hospital Affiliated to Fujian Medical University, Fuqing, Fuzhou, China Department of Ultrasound, First Medical Center, Chinese PLA General Hospital, Beijing, P. R. China Research Laboratory for Functional Nanomaterial, National Engineering Research Center for Nanotechnology, Shanghai 200241, People’s Republic of China. The State Key Laboratory Breeding Base for Sustainable Control of Pest and Disease Key Laboratory of Biotechnology in Plant Protection of MOA of China and Zhejiang Province Institute of Virology and Biotechnology Zhejiang Academy of Agricultural Sciences Hangzhou 310021 China Department of Dermatology and Pathology, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, New York, United States Department of Radiology, Union Hospital of Fujian Medical University, Fuzhou, Fujian, China Division of Hemostasis and Thrombosis, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA Lars Bolund Institute of Regenerative Medicine, Beijing Genomics Institute (BGI)-Qingdao, BGI-Shenzhen, Qingdao, China;; Department of Biomedicine, Aarhus University, Aarhus, Denmark; College of Fisheries, Huazhong Agricultural University, Wuhan 430070, China; State Key Laboratory of Freshwater Ecology and Biotechnology and Key Laboratory of Aquaculture Disease Control, Ministry of Agriculture, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China Department of Dermatology State University of New York at Buffalo Buffalo NY USA State Key Laboratory of Medical Genomics, Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health, National Clinical Research Center for Metabolic Diseases, Collaborative Innovation Center of Systems Biomedicine, and Shanghai Clinical Center for Endocrine and Metabolic Diseases Rui‐Jin Hospital, Shanghai Jiao‐Tong University School of Medicine Shanghai China; Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrine and Metabolic Diseases Rui‐Jin Hospital, Shanghai Jiao‐Tong University School of Medicine Shanghai China Department of Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine Shanghai China; Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China Shanghai Key Laboratory for Endocrine Tumor, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine Shanghai China Department of Medical Oncology, Fuzhou General Hospital of Nanjing Military Command, Fuzhou, Fujian, China (mainland) Department of Otorhinolaryngology Head and Neck Surgery, Huashan Hospital of Fudan University, Shanghai 200040, China. Tianjin Normal University Academy of Psychology and Behavior, Tianjin, China. State Key Laboratory of Marine Environmental Science/College of the Environment and Ecology, Xiamen University, Xiamen, China Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun, Jilin 130022, China School of Energy and Environmental Engineering, University of Science and Technology Beijing, Beijing 100083, China Clinical Laboratory, The First Hospital of Dalian Medical University, Dalian, Liaoning 116011, P.R. China Genetics and Genomic Medicine Research and Teaching Department, UCL Great Ormond Street Institute of Child Health, University College London, London, UK Department of Clinical Laboratory The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital Zhengzhou China; Zhengzhou Key Laboratory of Digestive System Tumor Markers Diagnosis Cancer Hospital of Zhengzhou University, Henan Cancer Hospital Zhengzhou China Department of Gastroenterology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China. Email: lin9100@aliyun.com. Department of Physiology and Biophysics State University of New York at Buffalo Buffalo New York USA National Laboratory of Solid State Microstructures College of Engineering and Applied Sciences Jiangsu Key Laboratory of Artificial Functional Materials Collaborative Innovation Center of Advanced Microstructures Nanjing University Nanjing 210093 China 1Department of Surgery, Section of General Thoracic Surgery and Departments of National Engineering Research Center for Nanotechnology; Shanghai 200241, China Zhejiang Provincial Key Laboratory of Health Risk Factors for Seafood, Zhejiang Ocean University, Zhoushan 316022, Zhejiang, People's Republic of China. School of Acupuncture-Moxibustion and Tuina, Shanghai University of TCM, Shanghai 201203, China. Traditonal Chinese Medicine Department Heilongjiang Institute for Drug Control Harbin P. R. China Department of Cardiology, Shandong Provincial Qianfoshan Hospital, The First Affiliated Hospital of Shandong First Medical University , Jinan, Shandong, China; Weifang Medical University , Weifang, Shandong, China Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, China Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China; Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China Shanghai Institute of Organic Chemistry, the Chinese Academy of Sciences, Shanghai 200032, China. Key Laboratory of Terrestrial Ecological Process, Institute of Applied Ecology, Chinese Academy of Sciences, Shenyang 110016, China. linlin576521@163.com Department of General Surgery, The Fourth Affiliated Hospital of China Medical University, China Plastic Surgery Hospital, Peking Union Medical College, Beijing, People's Republic of China. National Center for Chronic and Noncommunicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China Section on Molecular Neurophysiology and Biophysics, Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD), National Institutes of Health (NIH), Bethesda, MD 20892,USA Lawrence Berkeley National Laboratory 1 Computational Research Division, , Berkeley, California 94720, USA; University of California 2 Department of Mathematics, , Berkeley, California 94720, USA Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China; Obstetrical Department, The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China College of Clinical Medicine for Obstetrics and Gynecology and Pediatrics, Fujian Medical University, Fuzhou, Fujian Province, China; Department of Obstetrics and Gynecology, Fujian Maternity and Child Health Hospital, Fuzhou, Fujian Province, China. Materials Characterization & Preparation Center South University of Science and Technology of China Shenzhen 518055 China Learning Technologies, University of North Texas, Denton, Texas; Shanghai National Clinical Research Center for Endocrine and Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health of China, Shanghai Institute for Endocrine and Metabolic Diseases, Ruijin Hospital Shanghai Jiaotong University School of Medicine Shanghai China Division of Gastroenterology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan Department of Respiratory Medicine, The Second Clinical College of Guangzhou University of Chinese Medicine, Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China; Department of Gastroenterology, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029. lin9100@yahoo.com.cn Division of Gastroenterology, Department of Gastroenterology, First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, China Clinical and Molecular Genetics Unit (L.L., J.C.A.), Developmental Endocrinology Research Group, UCL Institute of Child Health, University College London, London WC1E 6BT, United Kingdom Computational Research Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, California 94720, United States; Department of Mathematics, University of California, 1083 Evans Hall, Berkeley, California 94720, United States College of Grassland Agriculture Northwest A&F University Yangling Shaanxi 712100 People's Republic of China Departments of Learning Technologies and Department of Molecular Biology and Genetics, Cornell University Ithaca New York 14853 USA Department of Cardiology, The First Affiliated Hospital of Shandong First Medical University , Jinan, Shandong, China Authors' Affiliations: 1Thoracic Surgery, Department of Surgery, University of Michigan Medical School, Ann Arbor, Michigan; and 2Translational Research Laboratory and Departments of 3Pathology, 4Thoracic Surgery, and 5Medical Oncology, Thoracic Oncology Multidisciplinary Unit, Catalan Institute of Oncology, L'Hospitalet de Llobregat, Barcelona, Spain Department of Gastroenterology First Affiliated Hospital of Nanjing Medical University Nanjing Jiangsu Province China Harbin Institute of Technology, 150001 Harbin, P.R.C. waiwaiyl@163.com Department of Gastroenterology, The First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, China. lin9100@aliyun.com. The Seventh Department of Plastic Surgery, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China Department of Gastroenterology, Qilu Hospital of Shandong University, Jinan, Shandong, China; Department of Nutritional Sciences; Faculty of Medicine; University of Toronto; Toronto; Canada Department of Biochemistry and Molecular Biology, MOE Key Laboratory of Geriatric Diseases and Immunology, Suzhou Medical College of Soochow University, Suzhou, People’s Republic of China Innovation Institute of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China Department of Biomedicine Aarhus University Denmark College of Physics and Energy, Fujian Normal University, Fuzhou 350117, China; Fujian Provincial Collaborative Innovation Center for Advanced High-Field Superconducting Materials and Engineering, Fuzhou 350117, China; Fujian Provincial Key Laboratory of Quantum Manipulation and New Energy Materials, Fujian Normal University, Fuzhou 350117, China Department of Internal Oncology, 301 General Hospital, Beijing, P.R. China Department of Radiology Affiliated Zhongshan Hospital of Dalian University Dalian People's Republic of China Department of Digestive Medicine, Tai'an City Central Hospital, Tai'an, Shandong 271000, P.R. China Developmental Endocrinology Research Group Clinical and Molecular Genetics Unit University College London Institute of Child Health, University College London London UK State Key Laboratory of Pharmaceutical Biotechnology; School of Life Sciences; Nanjing University; Nanjing 210023; China Department of Biomedicine, Aarhus University, Aarhus, Denmark. Department of Biomedicine, Aarhus University, Denmark School of Laboratory Medicine, Chengdu Medical College, Chengdu, Sichuan, PR China;; Laboratory of Veterinary Drug Residue Prevention and Control Technology of Animal-derived Food, Chengdu Medical College, Chengdu, Sichuan, PR China Department of Neurology, Center for Cognitive Neurology, Fujian Medical University Union Hospital, fuzhou, China; Fujian Institute of Geriatrics, Fujian Medical University Union Hospital, Fuzhou, China; Institute of Clinical Neurology, Fujian Medical University, Fuzhou, China; Fujian Key Laboratory of Molecular Neurology, Fujian Medical University, Fuzhou, China Department of Cell Biology Key Laboratory of Cell Biology, Ministry of Public Health, and Key Laboratory of Medical Cell Biology Ministry of Education School of Life Sciences China Medical University Shenyang City China Institute of Applied Chemistry College of Chemistry Nanchang University Nanchang 330031 P. R. China State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University; Yishui Central Hospital School of Food and Biological Engineering Jiangsu University Zhenjiang China Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, China State Key Laboratory of Agrobiotechnology College of Biological Sciences China Agricultural University Beijing China Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, State Key Laboratory of Molecular Engineering of Polymers, Collaborative Innovation Center of Chemistry for Energy Materials, Department of Chemistry, Fudan University, Shanghai 200433, P. R. China Department of Family Health Care Nursing University of California San Francisco California USA School of Food & Biological Engineering; Jiangsu University; Zhenjiang 212013, China State Key Laboratory of Coordination Chemistry, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Chemistry and Chemical Engineering Nanjing University Nanjing 210093 China Division of General Internal Medicine, Los Angeles Biomedical Research Institute at Harbor-University of California at Los Angeles, (UCLA) Medical Center, Torrance, California, USA; David Geffen School of Medicine at UCLA, Los Angeles, California, USA Department of Nutritional Sciences, University of Toronto, Toronto, ON M5S 1A1, Canada; Department of Anatomy and Neurobiology, Faculty of Medicine, University of California, Irvine, CA 92697, USA Department of Neurosurgery, The Second Hospital of Hebei Medical University, Shijiazhuang, China. College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, China School of Medicine Southern University of Science and Technology 1088 Xueyuan Blvd. Nanshan District Shenzhen, Guangdong 518055 P. R. China; Department of Neurosurgery Second Affiliated Hospital of Harbin Medical University Harbin 150086 P. R. China Department of Endocrine and Metabolic Diseases, Rui Jin Hospital North, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China. Institute of Dermatology Chinese Academy of Medical Science and Peking Union Medical College Nanjing China Shandong Center for Disease Control and Prevention, Jinan 250014, Shandong, PR China Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China Department of Gastroenterology, Changzheng Hospital Second Military Medical University Shanghai China Innovative Institute of Chinese Medicine and Pharmacy Shandong University of Traditional Chinese Medicine Jinan China *Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095;; †Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095; Department of Chemistry and Biochemistry, New Mexico State University, Las Cruces, NM 88003, USA. Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 P. R. China; University of Science and Technology of China Hefei 230026 P. R. China; Jilin Biomedical Polymers Engineering Laboratory Changchun 130022 P. R. China Department of Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine Shanghai China; Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine Ruijin Hospital, Shanghai Jiao Tong University School of Medicine Shanghai China Department of Gastroenterology and Hepatology, Tianjin Medical University General Hospital, Tianjin, China (mainland) Dept. of Preventive Dentistry, West China College of Stomatology, Sichuan University, Chengdu 610041, China. Department of Cardiac Surgery Intensive Care Unit The First Affiliated Hospital Sun Yat‐sen University Guangzhou China Department of Molecular Biology and Genetics 1 and 2; Department of Biomedical Engineering, Cornell University, Ithaca, NY 14853 1 and 2 Department of Gastroenterology, Peking University Third Hospital, Beijing 100191, China. Department of Hematology, The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, Jiangsu Province, China,The First Clinical College of Nanjing University of Chinese Medicine, Nanjing 210046, Jiangsu Province, China. Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangzhou 510120. drlinlin620@hotmail.com Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA. Key Laboratory for Chemical Biology of Fujian Province, College of Chemistry and Chemical Engineering, Xiamen University, 361005, Xiamen, China College of Animal Science and Technology, Henan University of Science and Technology, Kaiyuan Avenue 263, Luoyang 471000, Henan, People’s Republic of China State Key Laboratory of Coordination Chemistry Chemistry and Biomedicine Innovation Center (ChemBIC) School of Chemistry and Chemical Engineering Nanjing University Nanjing 210093 China Department of Biomedical Engineering, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio 44106, United States State Key Laboratory of Medical Genomics Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health, the Chinese Clinical Research Center for Metabolic Diseases, and Shanghai Clinical Center for Endocrine and Metabolic Diseases Shanghai China; Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrine and Metabolic Diseases Rui‐Jin Hospital Shanghai China Department of Radiology, Fujian Medical University Union Hospital, Fuzhou, PR China; School of Medical Technology and Engineering, Fujian Medical University, Fuzhou, China State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro‐Products, Institute of Plant Virology Ningbo University Ningbo China Department of Orthopedics, The First Hospital of Qiqihar, The Affiliated Qiqihar Hospital of Southern Medical University, Qiqihar, Heilongjiang, China Division of Gastroenterology, University of Texas Medical Branch, Galveston, Texas; Department of Chemistry, Zhengzhou University, Zhengzhou 450052, China. Auricular Reconstructive Center, Plastic Surgery Hospital, Chinese Acaderny of Medical Sciences, Beijing, 100144, China. School of Ecology and Environmental Sciences, Yunnan University, Kunming, Yunnan, China School of Food and Biological Engineering, Jiangsu University, Zhenjiang, China; State Key Laboratory of Utilization of Woody Oil Resource, Hunan Academy of Forestry, Changsha, China Department of Gynecology West China Second University Hospital of Sichuan University Chengdu China Guangdong Provincial Hospital of Chinese Medicine, Guangzhou 510120, China Ear Reconstruction Department, Plastic Surgery Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China Hunan Provincial Key Laboratory of Pediatric Respirology, Pediatric Medical Center, Hunan Provincial People’s Hospital (The First Affiliated Hospital of Hunan Normal University), Changsha 410000, China Reproductive Medicine Center Fujian Maternal and Child Health Care Hospital Fuzhou Fujian P. R. China UCL Institute of Child Health (L.L., B.F.-d.-S., D.K., M.T.D., J.C.A.), University College London, London WC1N 1EH, United Kingdom; Department of Medicine (L.L., B.F.S., G.S.C., J.C.A.), University College London, London WC1N 1EH, United Kingdom Software College, Northeastern University, Shenyang 110819, China Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China Department of Obstetrics, The Sixth Affiliated Hospital of Sun Yat‑sen University, Guangzhou, Guangdong 510655, P.R. China School of Biomedical Engineering, Southern Medical University, Guangzhou, Guangdong 510515, China Guangxi Key Laboratory of Marine Environmental Science, Guangxi Academy of Sciences, Nanning 530-007, P.R. China; College of Light Industry and Food Engineering, Guangxi University, Nanning 530-007, P.R. China Department of Gastroenterology The First Affiliated Hospital of Nanjing Medical University Nanjing Jiangsu Province China Women and Children's Hospital Affiliated to Xiamen University, Xiamen, Fujian Province, China. Shandong Academy of Pharmaceutical Sciences Jinan 250101 China State Key Laboratory of Marine Environmental Science, Environmental Science Research Centre, Xiamen University, Xiamen 361005, China Department of Otorhinolaryngology–Head and Neck Surgery Huashan Hospital of Fudan University Shanghai China Departments of Radiology and; School of Medical Technology and Engineering, Fujian Medical University, Fuzhou, China Department of Chemistry, National Dong Hwa University, Hualien 974, Taiwan Lineberger Comprehensive Cancer Center, Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC 27599; and Key Laboratory of Jiangxi Province for Environment and Energy Catalysis; The College of Chemistry; Nanchang University; Nanchang 330031; P. R. China State Key Laboratory of Pollution Control and Resource Reuse, School of Environmental Science and Engineering, Tongji University, 1239 Siping Road, Shanghai 200092, China Peking Union Medical College, Beijing 100021, P.R.China. Institue of Genetics and Biotechnology, University of Aarhus, DK-8830, Tjele, Denmark. State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products, Institute of Plant Virology, Ningbo University, Ningbo, 315211, PR China Department of Gastroenterology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China Department of Nephrology, Weifang People’s Hospital, No. 151 Guangwen Street, Kuiwen District, Weifang, Shandong 261041, China Applied Biomath Concord Massachusetts USA State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing 100193, China Developmental Endocrinology Research Group, Clinical and Molecular Genetics Unit, UCL Institute of Child Health, University College London, London, UK. Department of Medical Affairs, West China Second University Hospital, Sichuan University; Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, Sichuan, China (mainland) Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, 30-32 Ngan Shing Street, Shatin, Hong Kong College of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, China National Center for Protein Science and Shanghai Institute of Biochemistry and Cell Biology Chinese Academy of Sciences 333 Haike Road Shanghai 201210 P. R. China Departments of 1Medical Oncology and 2Gastrointestinal Surgery, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China Department of Radiation Oncology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, P.R. China Key Laboratory of Luminescence and Optical Information, Ministry of Education, Institute of Optoelectronic Technology, Beijing Jiaotong University, Beijing 100044, P. R. China Division of Hemostasis and Thrombosis, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA;; Department of Medicine, Harvard Medical School, Boston, MA a Department of Chemistry and Biochemistry , Brigham Young University , Provo , UT , USA Department of Respiratory Medicine, The Second Clinical College of Guangzhou University of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine and Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, Guangdong 510120, P.R. China Department of Pediatrics, Division of Pediatric Cardiology Laboratory of Solid State Microstructures, Nanjing University, Nanjing 210093, China School of Chemical and Environmental Engineering, Shanghai Institute of Technology, Shanghai 201418, People’s Republic of China; Research Laboratory for Functional Nanomaterial, National Engineering Research Center for Nanotechnology, Shanghai 200241, People’s Republic of China Materials Characterization and Preparation Center, South University of Science and Technology of China, Shenzhen, 518055, People's Republic of China. Department of Tumor Biotherapy (5th Ward of the Department of Oncology), Anhui Provincial Cancer Hospital, West District of The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, 230031, Hefei, Anhui Province, People’s Republic of China; Department of Oncology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, 230001, Hefei, Anhui Province, People’s Republic of China Department of Gastroenterology, Weihai Municipal Hospital, Cheeloo College of Medicine, Shandong University, Weihai, Shandong 264200, P.R. China *Department of Dermatology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599;; †Oral Biology Program, School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599; National Clinical Research Center for Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China Division of West-district Outpatient, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China Division of Hemostasis and Thrombosis; Department of Medicine; Beth Israel Deaconess Medical Center; Harvard Medical School; Boston Department of Cardiology, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou, Guangdong, China (mainland) Department of Biology, Queens College, Flushing, New York 11367; Department of General Surgery, The Second Hospital of Hebei Medical University, Shijiazhuang, China. Department of Gynaecology and Obstetrics, The Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China (mainland) The State Key Laboratory Breeding Base for Sustainable Control of Pest and Disease Institute of Plant Virology, Ningbo University Ningbo 315211 China; Key Laboratory of Biotechnology in Plant Protection of MOA and Zhejiang Province Institute of Virology and Biotechnology, Zhejiang Academy of Agricultural Sciences Hangzhou 310021 China Acupuncture and Tuina School, Shanghai University of Traditional Chinese Medicine, Shanghai, China. 325 Essjay Rd, Williamsville, NY 14221, USA. Richardson Centre for Functional Foods and Nutraceuticals; Departments of Food Science and Human Nutritional Sciences; University of Manitoba; Winnipeg; Manitoba; Canada Department of Radiology, Fujian Medical University Union Hospital, Fuzhou, Fujian, PR China Department of Biomedicine Aarhus University Aarhus Denmark; Steno Diabetes Center Aarhus Aarhus University Hospital Aarhus Denmark Department of Physiology, Zhejiang University School of Medicine, Zhejiang University, Hangzhou, China State Key Laboratory of Marine Environmental Science/College of the Environment and Ecology Xiamen University Xiamen China School of Biotechnology and Food Engineering, Key Laboratory for Agricultural Products Processing of Anhui Province Hefei Univ. of Technology 193 Tunxi Rd. Hefei 230009 Anhui China Gastroenterology Institute of Sports Medicine, Peking University Third Hospital, Beijing, PR China. Authors' Affiliations: 1Integrative Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada; and 2Department of Surgery, University of Michigan, Ann Arbor, Michigan School of Food and Biological Engineering Jiangsu University Zhenjiang 212013 P. R. China Office of Cyber Infrastructure and Computational Biology, National Institute of Allergy and Infectious Diseases, Molecular Neurophysiology and Biophysics Unit (D.A.H., M.M.H., L.L.), Bethesda, Maryland 20892 Department of Gastroenterology, The First Affiliated Hospital with Nanjing Medical University, Nanjing 210029, China School of Food & Biological Engineering, Jiangsu University, Zhenjiang, China Department of Applied Physics, College of Science, Nanjing Forestry University, Nanjing 210037, China Department of Neurobiology, Shanghai Jiao-Tong University School of Medicine, Shanghai, People's Republic of China Genetics and Genomic Medicine, UCL Great Ormond Street Institute of Child Health, University College London, London, United Kingdom The Seventh Department of Plastic Surgery, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100144, P.R. China Division of Dermatologic Surgery and Dermatopathology, Department of Dermatology, Buffalo Medical Group, Buffalo, NY. Department of Cancer Biology; University of Massachusetts Medical School; Worcester, MA, USA Radiology Department, Affiliated Union Hospital of Fujian Medical University, Fuzhou, China Key Laboratory of Polymer Ecomaterials; Changchun Institute of Applied Chemistry; Chinese Academy of Sciences; Changchun; China Departments of Pathology and Department of Radiology, Fujian Medical University Union Hospital, Fuzhou, Fujian, China Department of Clinical Laboratorial Examination, The First Hospital Affiliated to Dalian Medical University, Dalian 116000, Liaoning Province, China,E-mail: linlin_work@yeah.net. Department of Ultrasound, The First Medical Center, Chinese PLA General Hospital, Beijing, China Department of Medicine, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation and Tzu Chi University, Hualien, Taiwan State Key Laboratory of Medical Genomics National Clinical Research Center for Metabolic Diseases, Collaborative Innovation Center of Systems Biomedicine, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine Shanghai China; Shanghai Institute of Endocrine and Metabolic Diseases, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine Shanghai China Department of Respiratory Medicine, Guangdong Provincial Hospital of Chinese Medicine, Guangdong, China. The State Key Laboratory Breeding Base for Sustainable Control of Pest and Disease, Key Laboratory of Biotechnology in Plant Protection of MOA of China and Zhejiang Province, Institute of Virology and Biotechnology, Zhejiang Academy of Agricultural Sciences, Hangzhou, China State Key Laboratory of Nuclear Physics and Technology, Peking University , Beijing 100871, China College of Horticulture, South China Agricultural University, 510642, Guangzhou, China Department of Neurology, Center for Cognitive Neurology Fujian Medical University Union Hospital Fuzhou City China; Fujian Institute of Geriatrics Fujian Medical University Union Hospital Fuzhou City China; Institute of Clinical Neurology Fujian Medical University Fuzhou City China; Fujian Key Laboratory of Molecular Neurology Fujian Medical University Fuzhou City China Jiangsu Key Laboratory of Neuroregeneration Nantong University Nantong Jiangsu Province 226001 People's Republic of China Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, People’s Republic of China; University of Science and Technology of China, Hefei 230026, People’s Republic of China China-Australia Joint Research Center for Functional Molecular Materials; School of Chemical Science and Engineering; Tongji University; Shanghai 200092; China Department of Gastroenterology, Tianjin Medical University General Hospital Airport Hospital Tianjin Airport Economic Area Tianjin China Department of Statistics, Pennsylvania State University, University Park, Pennsylvania; and The Institute of Otorhinolaryngology, Chinese PLA General Hospital, Beijing, 100853, China. Department of Ophthalmology, Women and Children’s Hospital, School of Medicine, Xiamen University, Xiamen, China Section of General Thoracic Surgery, Department of Surgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA. Laboratory of Veterinary Drug Residue Prevention and Control Technology of Animal‐Derived Food Chengdu Medical College Chengdu PR China; School of Laboratory Medicine Chengdu Medical College Chengdu PR China State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro‐products Institute of Plant Virology Ningbo University Ningbo China; Key Laboratory of Biotechnology in Plant Protection of MOA and Zhejiang Province Zhejiang Academy of Agricultural Sciences Hangzhou China Department of Surgery, University of Michigan, Ann Arbor, MI 48109 Department of Obstetrics, The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, PR China; Laser Treatment Center, Plastic Surgery Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China. Obstetrics and Gynecology Hospital of Fudan University , Shanghai , China Anxi College of Tea Science, Fujian Agriculture and Forestry University, Quanzhou 362400, China Department of Cell Biology, Third Military Army Medical University, Chongqing 400038China Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor-University of California Los Angeles (UCLA) Medical Center and St. John's Cardiovascular Research Center, Torrance, California, USA; David Geffen School of Medicine at UCLA, Los Angeles, California, USA State Key Laboratory of Molecular Engineering of Polymers; Collaborative Innovation Center of Chemistry for Energy Materials; Department of Chemistry; Fudan University; Shanghai 200433 Applied BioMath Lincoln Massachusetts USA 1Department of Etiology and Carcinogenesis, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. Department of Medical Oncology Cancer Institute/Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China Division of Hemostasis and Thrombosis Beth Israel Deaconess Medical Center Harvard Medical School Boston MA USA Plastic Surgery Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing 100144, China; and Department of Pathology, the State University of New York College at Buffalo, Buffalo, NY Laboratory of Cellular and Molecular Biology, Jiangsu Province Institute of Traditional Chinese Medicine, 100 Shizi Street, Hongshan Road, Nanjing, Jiangsu 210028, China Department of Physiology & Biophysics, State University of New York at Buffalo, Buffalo, NY, USA The State Key Laboratory Breeding Base for Sustainable Control of Pest and Disease, Zhejiang Academy of Agricultural Sciences, Hangzhou, China; Key Laboratory of Biotechnology in Plant Protection of MOA of China and Zhejiang Province, Institute of Virology and Biotechnology, Zhejiang Academy of Agricultural Sciences, Hangzhou, China Department of Medicine, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation and School of Medicine, Tzu Chi University, Hualien, Taiwan Key Laboratory for Nuclear‐Agricultural Sciences of Chinese Ministry of Agriculture and Zhejiang Province Institute of Nuclear‐Agricultural Sciences, Zhejiang University Hangzhou China National Laboratory of Solid State Microstructures, College of Engineering and Applied Sciences, Jiangsu Key Laboratory of Artificial Functional Materials, Collaborative Innovation Center of Advanced Microstructures, Nanjing University, Nanjing 210023, China Department of Clinical Laboratory, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China. School of Biotechnology and Food Engineering, Hefei University of Technology, Hefei, Anhui, China. Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania; Department of Chemistry, Key Laboratory of Analytical Sciences, College of Chemistry, Chemical Engineering, Xiamen University, China Authors' Affiliations: Departments of 1Medical Oncology, 2Cancer Biology and 3Center for Cancer Genome Discovery, Dana-Farber Cancer Institute, Boston, Massachusetts; Department of 4Medicine and 5Pathology, Brigham and Women's Hospital, Boston, Massachusetts; Departments of 6Medicine and 7Pathology, Harvard Medical School, Boston, Massachusetts; 8Broad Institute, Cambridge, Massachusetts; 9Section of Thoracic Surgery, Department of Surgery and 10Department of Pathology, University of Michigan, Ann Arbor, Ann Arbor, Michigan; 11Department of Surgery, University of Rochester, Rochester, New York; 12Department of Cardiothoracic Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania; 13Department of Medical Oncology, Hospital Vall d'Hebron, Passeig Vall d'Hebron, Barcelona, Spain; 14Department of Human Pathology and Oncology, University of Siena, Siena, Italy; 15Division of Hematology and Oncology, Massachusetts General Hospital, Boston, Massachusetts; 16Department of Epidemiology, Harvard School of Public Department of Gastroenterology The First Affiliated Hospital of Nanjing Medical University Nanjing China State Key Laboratory of Marine Environmental Science/College of the Environment and Ecology Xiamen University Xiamen 361005 China Department of Mechatronics Engineering, Harbin Institute of Technology, Harbin, China |
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