http://rdf.ncbi.nlm.nih.gov/pubchem/author/MD5_15552c9620a437059ac5c8cce700ed36
Outgoing Links
Predicate | Object |
---|---|
family-name | Chen Lei Chen |
name | Lei Chen |
given-name | Lei |
organization-name | Blood Transfusion Department, The First Hospital Affiliated to AMU, Southwest Hospital of Chongqing, Chongqing 400038, China. National Institute for Advanced Materials; School of Materials Science and Engineering; Nankai University; Tianjin 300353; China State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Institute of Physics and Mathematics, the Chinese Academy of Sciences, Wuhan 430071, People's Republic of China Biotechnology Research Center/Hubei Province Key Laboratory of Natural Products Research and Development, China Three Gorges University, Yichang 443002, P.R. China, Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100190, P.R. China, Department of Oral and Maxillofacial Surgery, Daping Hospital, Research Institute of Sugery, Third Military Medical University, Chongqing 400042, P.R. China, and Department of Gynecology... Department of Interventional Oncology, Suzhou Municipal Hospital, Affiliated to Nanjing Medical University, Suzhou, Jiangsu, China. The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325027, P.R. China School of Physics and Materials Science, Guangzhou University, Guangzhou 510006, PR China Department of Pathology and Laboratory Medicine The University of Texas Health Science Center at Houston Houston Texas USA; Department of Laboratory Medicine The University of Texas MD Anderson Cancer Center Houston Texas USA Department of Microbiology, University of Washington, Seattle, Washington 98195 Section of Pediatric Emergency Medicine, Department of Pediatrics, Yale University School of Medicine, New Haven, CT. University of Michigan, Ann Arbor, MI Urology, LONGHUA Hospital Shanghai University of Traditional Chinese Medicine, Shanghai, China Division of Cardiovascular Diseases, Cardiovascular Research Institute, University of Kansas Medical Center, Kansas City, KS, United States. School of Pharmaceutical Science & Technology Tianjin University 92 Weijin Road, Tianjin University China Department of Burn Surgery, First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China; Division of Plastic and Reconstructive Surgery, Department of Surgery, Duke University Medical Center, Durham, NC. School of Traditional Chinese Medicine in Southern Medical University, Guangzhou, China. Musculoskeletal Tissue Bank, Beijing Jishuitan Hospital, Beijing 100035, P.R. China CAS Engineering Laboratory for Nanozyme Institute of Biophysics Chinese Academy of Sciences Beijing 100101 China State Key Laboratory of Functions and Applications of Medicinal Plants, Engineering Research Center for the Development and Application of Ethnic Medicine and TCM (Ministry of Education), Guizhou Provincial Key Laboratory of Pharmaceutics, School of Pharmacy, Guizhou Medical University, Guiyang 550004, China Department of Neurosurgery, Affiliated Hospital of Beihua University, Jilin 132000, P.R. China Department of Computer Science Sam Houston State University 1903 Ave I Huntsville TX 77341 Biotherapeutics, Biocytogen Pharmaceuticals (Beijing) Co. Ltd., #12 Baoshennan St, Daxing District, Beijing 102629, China Shanghai Institute of Immunology, Department of Immunology and Microbiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, China Department of Neurology West China Hospital of Sichuan University Chengdu China Shanghai Institute of Immunology, School of Medicine, Shanghai Jiao Tong University, Shanghai 200025, China College of Engineering, Shenyang Agricultural University, Shenyang, 110866, China Department of Economics University of Connecticut The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China; Shanghai Key Laboratory of Embryo Original Diseases, Shanghai, China; Shanghai Municipal Key Clinical Specialty, Shanghai, China College of Chemistry State Key Laboratory of Elemento-Organic Chemistry Nankai University Tianjin 300071 P. R. China Department of Orthopedics, the First Affiliated Hospital of Fujian Medical University, Fuzhou Fujian, 350004, P.R.China.fjydgk@126.com. i-Lab, CAS Center for Excellence in Nanoscience, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou 215123, China College of Mechanical and Vehicle Engineering, National Engineering Research Centre for High Efficiency Grinding, Hunan University, Changsha 410082, China; Greater Bay Area Innovation Institute, Hunan University, Guangzhou 511300, China Ocean College, Zhejiang University, Zhoushan, China Department of Obstetrics and Gynecology; Navy General Hospital of People Liberation Army; Beijing 100048; PR China Institute of Sericulture and Tea, Zhejiang Academy of Agricultural Sciences, Hangzhou 311251, China Biyang First High School, Wenming Road, Biyang, Henan, China School of Life Sciences and Biotechnology Dalian University of Technology Dalian 116024 China School of Materials Science and Engineering, Hefei University of Technology, Hefei 230009, China; National Joint Engineering Research Center for Abrasion Control and Molding of Metal Materials & Henan Key Laboratory of High-Temperature Structural and Functional Materials, Henan University of Science and Technology, Luoyang 471003, China; Intelligent Manufacturing Institute of HFUT, Hefei 230051, China Department of Cardiology The Second Xiangya Hospital of Central South University Changsha China State Key Laboratory of Functions and Applications of Medicinal Plants, School of Pharmacy, Engineering Research Center for the Development and Application of Ethnic Medicine, TCM (Ministry of Education), Guizhou Medical University, Guiyang 550004, People's Republic of China Laboratory of Synthetic Microbiology, School of Chemical Engineering & Technology Tianjin University Tianjin China; Key Laboratory of Systems Bioengineering (Ministry of Education) Tianjin University Tianjin China; SynBio Research Platform Collaborative Innovation Center of Chemical Science and Engineering (Tianjin) Tianjin China Department of Neurology, Joint Research Institution of Altitude Health, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan Surgical Department I, Urology Department, Longhua Hospital Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China Center for Nanoscale Science and Technology, National Institute of Standards and Technology, Gaithersburg, MD 20899; and State Key Laboratory of Tribology, School of Mechanical Engineering, Tsinghua University, Beijing100084, China Key Laboratory of Biofuels, Qingdao Engineering Research Center of Biomass Resources and Environment, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao 266101, China Department of Neurosurgery, Tangdu Hospital, Fourth Military Medical University Xi'an, Shaanxi 710038, PR China. Department of Pediatric Emergency Medicine Chongqing Academy of Animal Science, Chongqing, China Department of Radiation Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy Sun Yat‐sen University Cancer Center Guangzhou China; Department of Radiation Oncology University of Texas MD Anderson Cancer Center Houston Texas State Key Laboratory of Microbial Technology, Marine Biotechnology Research Center, Shandong University, Jinan 250100, PR China Department of Ophthalmology, Tenth People’s Hospital of Tongji University, Shanghai, China (mainland) Key Laboratory of Functional Materials Physics and Chemistry of the Ministry of Education; Jilin Normal University; Changchun 130103; P. R. China The International Cooperation Laboratory on Signal Transduction, Eastern Hepatobiliary Surgery Hospital,Second Military Medical University,Shanghai,China; National Center for Liver Cancer,Shanghai,China; Fudan University Shanghai Cancer Center; Department of Oncology, Shanghai Medical College,Fudan University,Shanghai 200032,China Guangdong Provincial Key Laboratory of Biomedical Imaging, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, Guangdong, China; Department of Neurosurgery, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, Guangdong, China Department of Physiology, School of Medicine, Qingdao University, Qingdao 266071, China. chenleiqd@163.com. Shanghai Institute of Immunology, Department of Immunology and Microbiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, China 1 Department of Urology Sun Yat‐Sen University Cancer Center Guangzhou China; State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine Sun Yat‐sen University Cancer Center Guangzhou China Department of General Surgery, Qilu Hospital of Shandong University (Qingdao), Qingdao, China Department of Dermatology, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital and West China School of Pharmacy, Sichuan University, Chengdu 610041, China Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, People's Republic of China State Key Laboratory of Heavy Oil Processing, China University of Petroleum-Beijing, Beijing 102249, China School of Chemistry and Chemical Engineering, Shandong University of Technology, Zibo, Shandong 255049, China State Key Laboratory of Supramolecular Structure and Materials, Jilin University, Changchun, P.R. China; Department of Chemistry, Kangwon National University, Chuncheon, Korea Department of Intensive Care Unit, The Sixth Affiliated Hospital Sun Yat‐sen University Guangzhou China Department of Chemistry and Chemical Biology, Cornell University , Ithaca, New York 14853-1301, USA The International Cooperation Laboratory on Signal Transduction,Eastern Hepatobiliary Surgery Hospital,Second Military Medical University,Shanghai,China; Fudan University Shanghai Cancer Center,Shanghai,China; Department of Oncology,Shanghai Medical College,Fudan University,Shanghai,China; National Center for Liver Cancer,Shanghai,China Tribology Research Institute, National Traction Power Laboratory, Southwest Jiaotong University, Chengdu 610031, China Department of Hematology, Liaocheng People's Hospital, Liaocheng, Shandong Province, China. Institute of Hematology, Union Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan China; Hubei Clinical Medical Center of Cell Therapy for Neoplastic Disease Wuhan China Department of Oncology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. 100491985@qq.com Department of Radiation Oncology, Sun Yat‐sen University Cancer Centre State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Collaborative Innovation Centre for Cancer Medicine Guangzhou People's Republic of China Department of Obstetrics and Gynecology Navy General Hospital of People Liberation Army Beijing 100048 P. R. China Department of Neurosurgery, Xi’an International Medical Center, Xi’an, China The State Key Laboratory Breeding Base of Basic Science of Stomatology & Key Laboratory of Oral Biomedicine Ministry of Education Wuhan University Wuhan China Institute of Ensiling and Processing of Grass Nanjing Agricultural University Nanjing 210095 China Department of Pharmacy, State Key Laboratory of Biotherapy West China Hospital, Sichuan University Chengdu China; Laboratory of Clinical Pharmacy and Adverse Drug Reaction, State Key Laboratory of Biotherapy West China Hospital, Sichuan University Chengdu China University of Kentucky, Department of Physiology, Spinal Cord and Brain Injury Research Center, Lexi Department of Pulmonary and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. Beijing Biocytogen Co., Ltd, Beijing 101111, China Graduate School of Human and Environmental Studies Kyoto University Department of Physiology, Qingdao University College of Medicine, Qingdao, 266071 Shandong, China; Department of Oncology, The Second Affiliated Hospital of Soochow University, Suzhou Medical Center of Radiotherapy and Oncology, Suzhou - China Tribology Research Institute, Key Laboratory of Advanced Technologies of Materials, Ministry of Education of China, Southwest Jiaotong University, Chengdu 610031, People's Republic of China Department of Urology, Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China. College of Chemistry State Key Laboratory of Elemento‐Organic Chemistry Nankai University Tianjin 300071 P. R. China Key Laboratory of Ethnomedicine of Ministry of Education, Center on Translational Neuroscience, School of Pharmacy, Minzu University of China, Beijing, China Department of Pathology and Laboratory Medicine, University of Texas McGovern Medical School at Houston, Houston, Texas, USA lei.chen.1@uth.tmc.edu. Department of Otolaryngology and Neck Surgery, Chinese PLA General Hospital, Beijing, China Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan, 430022 , China Department of General Surgery, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200092, China Shanghai Institute of Drug Discovery, Zhejiang Hisun Pharmaceutical Co., Ltd., Building 25, 301 Minqiang Road, Shanghai 201612, China; Zhejiang Hisun Pharmaceutical Co., Ltd., 46 Waisha Road, Taizhou, Zhejiang 318000, China The International Cooperation Laboratory on Signal Transduction, Eastern Hepatobiliary Surgery Hospital,Second Military Medical University,Shanghai,China; National Center for Liver Cancer,Shanghai,China College of Life Sciences Nankai University Tianjin China Department of Neurosurgery Fudan University Shanghai Cancer Center Shanghai China; Department of Oncology Shanghai Medical College Fudan University Shanghai China East District of Suzhou Municipal Hospital, Suzhou, Jiangsu 215001, China Division of Cardiology, Shanghai Immune Therapy Institute, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, People’s Republic of China Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853, United States Department of Hematology, General Hospital of Tianjin Medical University, Tianjin, China Center for Mitochondrial Biology & Medicine, The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Frontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an, China. State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen 361102, China College of Plant Protection Shandong Agricultural University Taian Shandong Province China; State Key Laboratory of Crop Biology Taian Shandong Province China Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, Jiangsu, China. Key Laboratory of Industrial Biotechnology Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi 214122, Jiangsu, China. Department of Burns and Plastic Surgery The First Affiliated Hospital of Wannan Medical College Wuhu China State Key Laboratory of Separation Membranes and Membrane Processes; School of Textiles; Tianjin Polytechnic University; Tianjin 300387; China Department of Neuropsychiatry, Hirosaki University; Department of Neurology, West China Hospital, Sichuan University State Key Laboratory of Analytical Chemistry for Life Sciences; Jiangsu Key Laboratory of Advanced Organic Materials; School of Chemistry and Chemical Engineering; Chemistry and Biomedicine Innovation Center; Nanjing University Eli Lilly and Company, Indianapolis, Indiana Department of Burns, The Fourth Tianjin Hospital, Tianjin 300222, P.R. China. Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, VIC. Department of Mechanical Engineering, Tsinghua University, Beijing 100084, P. R. China Division of Applied Biosciences, College of Agriculture and Life Sciences, Kyungpook National University, 1370 Sankyuk, Daegu 702-701, Republic of Korea China Medical University Shenyang China Department of Pharmacy, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University. Chengdu China; Laboratory of Clinical Pharmacy and Adverse Drug Reaction, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu China College of Life Sciences, Institute for Conservation and Utilization of Agro-bioresources in Dabie Mountains, Henan Key Laboratory of Tea Plant Biology, Xinyang Normal University, Xinyang 464000, China Department of Surgery, Miller School of Medicine, University of Miami, Miami, FL 33136, USA Aerospace Research Institute of Materials and Processing Technology; Beijing 100074; China Laboratory of Synthetic Microbiology, School of Chemical Engineering and Technology, Tianjin University, Tianjin, P.R. China; Frontier Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering, Ministry of Education of China, Tianjin, P.R. China Key Laboratory of Ethnomedicine for Ministry of Education, Center on Translational Neuroscience, College of Life and Environmental Sciences Minzu University of China Beijing China College of Engineering, Peking University , Beijing, China State Key Laboratory for Agro-Biotechnology, China Agricultural University Beijing, China. 1International Cooperation Laboratory on Signal Transduction, Eastern Hepatobiliary Surgery Institute, Second Military Medical University; and Laboratory of Protein Engineering Beijing Institute of Biotechnology Beijing China Department of Radiology Peking University People's Hospital Beijing P. R. China Department of Orthopedics, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China Beijing Institute of Biotechnology Beijing China Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Canton, Guangdong, China Department of Obstetrics and Gynecology, Maternal and Child Health Care Hospital Affiliated with Anhui Medical University, Anhui Maternal and Child Health Care Hospital, Hefei, China College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, Jiangsu 210095, China Key Laboratory of Monitoring and Management of Crop Pathogens and Insect Pests, Ministry of Agriculture of P.R. China, Nanjing Agricultural University, Nanjing 210095, China Center for Cancer & Inflammation Research, School of Chinese Medicine, Hong Kong Baptist University, Kowloon, Hong Kong, China School of Chemistry and Chemical Engineering; Shihezi University; Xinjiang Uygur Autonomous Region; People's Republic of China Department of Endocrinology, Peking University First Hospital, No. 8 Xishiku Avenue, Xicheng District, Beijing 100034, China Key Laboratory of Preparation and Applications of Environmental Friendly Materials, Ministry of Education; Department of Chemistry, Jilin Normal University, Siping, China; Department of Chemistry, Institute for Molecular Science and Fusion Technology, Kangwon National University, Chunchon 24341, Republic of Korea Department of Evidence‐Based Medicine Center Xiangyang No.1 People's Hospital Hubei University of Medicine Xiangyang China Department of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, P.R. China Chongqing University Research Center of Sensors and Instruments, College of Optoelectronic Engineering, , Chongqing City 400044, People's Republic of China Department of Pain Relief, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy (Tianjin) Tianjin's Clinical Research Center for Cancer Tianjin Laboratory of Synthetic Microbiology, School of Chemical Engineering & Technology, Tianjin University, Tianjin, PR China; Key Laboratory of Systems Bioengineering (Ministry of Education), Tianjin University, Tianjin, PR China; SynBio Research Platform, Collaborative Innovation Center of Chemical Science and Engineering, Tianjin, PR China Beijing Research Institute of Orthopedics and Traumatology, Beijing Jishuitan Hospital, Beijing100035, People’s Republic of China Centre for Molecular Imaging and Nuclear Medicine School for Radiological and Interdisciplinary Sciences (RAD‐X) Soochow University Collaborative Innovation Centre of Radiation Medicine of Jiangsu Higher Education Institutions Suzhou 215123 China Department of Bio‐medical Engineering Southern University of Science and Technology Shenzhen 518055 P. R. China Farm Animal Genetic Resource Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, China; Key Laboratory of Livestock and Poultry Multi-omics, Ministry of Agriculture and Rural Affairs, College of Animal and Technology, Sichuan Agricultural University, Chengdu 611130, China Department of Neurosurgery, Wuxi Clinical College of Anhui Medical University, 904th Hospital of Joint Logistic Support Force of PLA, Wuxi 214044, China College of Animal Science and Technology; Sichuan Agricultural University; Chengdu; China; Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province Department of Hematology, Union Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei, P.R. China. Department of Neurosurgery, 101st Hospital of PLA (Wuxi Taihu Hospital), Clinical Medical School of Anhui Medical University, Wuxi, P.R. China Department of Molecular Oncology, Eastern Hepatobiliary Surgical Hospital & National Center of Liver Cancer, The Second Military Medical University, Shanghai, China Center of Stomatology, Xiangya Hospital of Central South University, Changsha 410008, China. Institute of Systems Biology, Shanghai University, Shanghai 200444, China; College of Information Engineering, Shanghai Maritime University, Shanghai 201306, China School of Bioengineering, Dalian University of Technology, Dalian, China; State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing, China Department of Burns, First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China School of Life Sciences, Sun Yat-sen University, Guangzhou, People’s Republic of China School of Pharmacy, Second Military Medical University, Shanghai 200433. Department of Environmental Science, Zhejiang University, Hangzhou, Zhejiang 310058, People’s Republic of China; Zhejiang Provincial Key Laboratory of Organic Pollution Process and Control, Department of Environmental Science, Zhejiang University, Hangzhou, Zhejiang 310058, People’s Republic of China Departments of ICU , the Fourth Hospital of Hebei Medical University , Shijiazhuang Hebei , China School of Energy and Power Engineering Qilu University of Technology (Shandong Academy of Sciences) Jinan China Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan China College of Food Science and Technology, Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety, Guangdong Province Engineering Laboratory for Marine Biological Products, Guangdong Provincial Engineering Technology Research Center of Seafood, Key Laboratory of Advanced Processing of Aquatic Product of Guangdong Higher Education Institution, Guangdong Ocean University Zhanjiang, China Department of Clinical Laboratory, Yuhuangding Hospital of Qingdao University, Yantai, China College of Food Science and Technology Huazhong Agricultural University Wuhan China Department of Physical Sciences, United Technologies Research Center, East Hartford, Connecticut 06108, United States International Cooperation Laboratory on Signal Transduction, Eastern Hepatobiliary Surgery Institute,Second Military Medical University,Shanghai,China; National Center for Liver Cancer,Shanghai,China 1Center for Mitochondrial Biology and Medicine, The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, Shaanxi, China. Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou, Guangdong, People's Republic of China; Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA Guangdong Laboratory of Lingnan Modern Agriculture, Genome Analysis Laboratory of the Ministry of Agriculture and Rural Affairs, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen 518120, China Division of Vital Statistics, Institute of Health Information, Shanghai Municipal Center for Disease Control and Prevention , 1380 West Zhongshan Road, Shanghai 200336 , China Department of Neurosurgery Wuxi Medical College of Anhui Medical University (l0lst Hospital of PLA) Wuxi City Jiangsu Province PR. China Pizhou County Center for Disease Control and Prevention, Pizhou, China Brain center, Shenzhen Key Laboratory of Neurosurgery, Shenzhen Second People’s Hospital, Shenzhen University 1st Affiliated Hospital, Shenzhen 518035, China School of Artificial Intelligence, Anhui University of Science and Technology, Huainan 232001, China Guangdong Provincial Key Laboratory of Biotechnology for Plant Development, School of Life Sciences, South China Normal University, Guangzhou, China Department of Respiratory Diseases, Ningbo First Hospital, Zhejiang, China Institute for Signal Processing, University of Luebeck, Germany. Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, College of Life Sciences, Jilin University, Changchun, 130012, China; Institute of Atomic and Molecular Physics, Jilin University, Changchun 130012, China Institute of Low Temperature Science, Hokkaido University Faculty of Pharmacy, Zhejiang Pharmaceutical College, Ningbo, PR China National Center for Liver Cancer Shanghai 200438 China; The International Cooperation Laboratory on Signal Transduction Eastern Hepatobiliary Surgery Hospital Second Military Medical University Shanghai 200438 China; Fudan University Shanghai Cancer Center Department of Oncology Shanghai Medical College Fudan University Shanghai 200032 China Shanghai Institute of Immunology, Translational Medicine Center, Shanghai General Hospital Shanghai Jiao Tong University School of Medicine Shanghai China Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University National Clinical Research Center for Digestive Disease Beijing Digestive Disease Center Beijing Key Laboratory for Precancerous Lesion of Digestive Disease Beijing China College of Information Engineering, Shanghai Maritime University, Shanghai 201306, People's Republic of China Department of Burns The First Affiliated Hospital of Sun Yat‐sen University Guangzhou China Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Hubei Province Key Laboratory of Molecular Imaging, Wuhan, China Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan People's Republic of China ADC Therapeutics Inc., New Providence, NJ, USA Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices; Institute of Functional Nano and Soft Materials (FUNSOM) and Collaborative Innovation Center of Suzhou Nano Science and Technology; Soochow University; Suzhou 215123, P. R. China Department of Urology The First Affiliated Hospital of Anhui Medical University Hefei China; Institute of Urology Anhui Medical University Hefei China; Anhui Province Key Laboratory of Genitourinary Diseases Anhui Medical University Hefei China Catalytic Hydrogenation Research Center, State Key Laboratory Breeding Base of Green Chemistry-Synthesis Technology, Key Laboratory of Green Pesticides and Cleaner Production Technology of Zhejiang Province, Zhejiang University of Technology, Hangzhou 310014, P. R. China College of Traditional Chinese Materia Medica Guangdong Pharmaceutical University Guangzhou China Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China; Graduate University of Chinese Academy of Sciences, Beijing 100049, China National Research Center for High-Efficiency Grinding, College of Mechanical and Vehicle Engineering, Hunan University, Changsha 410082, P. R. China; Greater Bay Area Institute for Innovation, Hunan University, Guangzhou 511300, P. R. China Oncology Research Department of Gastroenterology, Southwest Hospital Army Medical University (Third Military Medical University) 30 Gaotanyan, Shapingba District Chongqing 400038 China Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Minimally Invasive Gastrointestinal Surgery, Peking University Cancer Hospital and Institute, Beijng 100142, China. suxiangqian@bjmu.edu.cn. Department of Chemistry, iChEm (Collaborative Innovation Center of Chemistry for Energy Materials), State Key Laboratory of Molecular Engineering of Polymers, Fudan University, Shanghai 200433, People’s Republic of China Department of Pathology, The University of Texas Medical School at Houston Department of Gastroenterology Renmin Hospital of Wuhan University Wuhan China; Key Laboratory of Hubei Province for Digestive System Diseases Renmin Hospital of Wuhan University Wuhan China Faculty of Environmental and Life Sciences, Beijing University of Technology, Beijing 100124, China School of Chemistry and Chemical Engineering University of South China Hengyang 421001 China Institute of Functional Nano & Soft Materials (FUNSOM) and Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University, Suzhou, Jiangsu 215123, China Institute of Ensiling and Processing of Grass, College of Animal Science and Technology Nanjing Agricultural University Nanjing China Molecular Neuroscience and Vascular Biology Laboratory, Department of Neurosurgery, University of Kentucky Medical Center, Lexington, Kentucky, USA Beijing Ruihua Heart Rehabilitation Research Center China Department of Surgery, Qingdao Municipal Hospital, Qingdao 266011, Shandong Province, China. College of Plant Protection, Shandong Agricultural University, Taian, Shandong Province 271018, China; State Key Laboratory of Crop Biology, Shandong Agricultural University, Taian, Shandong Province 271018, China Department of Burn and Plastic Surgery, First Affiliated Hospital of Wannan Medical College, Wuhu, Anhui 241001, P.R. China Department of Gastroenterology Taixing People's Hospital Taixing China Department of Surgery, Center for Cancer Research, and Department of Chemistry, The University of Hong Kong, Pokfulam, Hong Kong, Department of Surgery, Peking University, People’s Hospital, Beijing, China, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, and Quantitative Molecular Medicine, The Manchester Interdisciplinary Biocentre, University of Manchester, Manchester, United Kingdom From the Departments of Medicine (L.A.B., K.L.M., W.X., A.C.P., M.M.K., K.M.M., J.M.H.), Surgery (D.G., L.C., C.W.), and Anesthesia and Critical Care Medicine (D.E.B.) and the Institute for Cell Engineering (J.M.H.), Johns Hopkins University School of Medicine, Baltimore, Md. School of Stomatology, Shandong University, Jinan City, Shandong Province, China; Shandong Provincial Key Laboratory of Oral Tissue Regeneration, Jinan City, Shandong Province, China State Key Laboratory of Coordination Chemistry, Nanjing National Laboratory of Microstructures, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, China CAS Engineering Laboratory for Nanozyme, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China Department of Spine Surgery, Tongji Hospital, Tongji University School of Medicine, Shanghai, China. Key Laboratory of Occupational Health and Environmental Medicine, Jining Medical College, Jining 272013, China. Department of Research and Development, Shenzhen Institute for Innovation and Translational Medicine, Shenzhen International Biological Valley-Life Science Industrial Park, Shenzhen, PR China Center for Clinical Research and Translational Medicine, Yangpu Hospital, School of Medicine, Tongji University, Shanghai, P. R. China Department of Thoracic Surgery Renmin Hospital of Wuhan University Wuhan University of Science and Technology Beijing, Department of Computer Science and Technology, School of Computer and Communication Engineering, Beijing, Beijing, China University of Kentucky, Spinal Cord and Brain Injury Research Center, Department of Physiology, Lexington, Kentucky, United States School of Chemical Engineering & Technology, Tianjin University, Tianjin, People's Republic of China; Key Laboratory of Systems Bioengineering, Ministry of Education, Tianjin, People's Republic of China State Key Laboratory for Agrobiotechnology; Institute of Plant Molecular Biology and Agricultural Biotechnology; School of Life Sciences; The Chinese University of Hong Kong; Shatin Hong Kong Department of Radiation Oncology Sun Yat‐sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine Guangzhou People's Republic of China Department of Neurosurgery the First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital 3002# Sungang Road, Futian District Shenzhen 518035 China; Shenzhen Key Laboratory of Neurosurgery 3002# Sungang Road, Futian District Shenzhen 518035 China Food, Nutrition and Health Program, Faculty of Land and Food Systems, The University of British Columbia, Vancouver, British Columbia, Canada; Department of Chemistry, Faculty of Science, The University of British Columbia, Vancouver, British Columbia, Canada State Key Laboratory of High Performance Ceramics and Superfine Microstructure; Shanghai Institute of Ceramics; Chinese Academy of Sciences; Shanghai 200050; PR China Baker Heart and Diabetes Institute Melbourne Victoria Australia Department of Spine Surgery, Tongji Hospital, School of Medicine, Tongji University, Shanghai 200065, China; Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration, Ministry of Education, Department of Spine Surgery, Tongji Hospital, School of Medicine, Tongji University, Shanghai 200065, China International Cooperation Laboratory on Signal Transduction, Eastern Hepatobiliary Surgery Institute, Second Military Medical University, Shanghai 200438, P.R. China; National Center for Liver Cancer, Shanghai 201805, P.R. China Department of Thyroid and Breast Surgery, Shanghai 10th People’s Hospital, Clinical College of Nanjing Medical University, Shanghai, China (mainland) Department of Thoracic Surgery, Peking University Shougang Hospital, Beijing 100144, P.R. China Shanghai Maritime University, Pudong, Shanghai, China Engineering Research Center of Optical Instrument and Systems, Ministry of Education and Shanghai Key Lab of Modern Optical System, University of Shanghai for Science and Technology, No. 516 Jun Gong Road, Shanghai 200093, P.R. China Department of Plant Quarantine, Shanghai Extension and Service Center of Agriculture Technology, Shanghai 201103, China College of Otolaryngology Head and Neck Surgery, Chinese PLA General Hospital, Chinese PLA Medical School, Beijing 100853, China; National Clinical Research Center for Otolaryngologic Diseases, Beijing 100853, China From Sarepta Therapeutics, Inc (J.S.C., F.J.S., J.D., C.D., J.V., U.D., B.W., D.F.), Cambridge, MA; Nationwide Children's Hospital (S.L., L.C., L.R.R.-K., Z.S., J.R.M.), Columbus, OH; and Flagship Biosciences (G.D.Y., A.J.M.), Westminster, CO. State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Road, Shanghai 200032, China, and State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031, China Department of Cardiovascular Surgery, Beijing Aortic Disease Center, Beijing Anzhen Hospital, Capital Medical University, Beijing, China Key Labs for Advanced Materials and Institute of Fine Chemicals; East China University of Science and Technology; Shanghai 200237, China Department of Obstetrics and Gynecology, Navy General Hospital of People Liberation Army, Beijing 100048, PR China Guangdong Provincial Key Laboratory of Sensor Technology and Biomedical Instrument, School of Biomedical Engineering, Sun Yat-sen University, Guangzhou 510275, China Department of Virology, School of Public Health, Shandong University, Jinan 250012, China. Department of Respiratory and Critical Care Medicine, West China Hospital, West China School of Medicine, Sichuan University, Chengdu, Sichuan, People’s Republic of China State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of Technology Wuhan 430070 China Guangdong Provincial Key Laboratory of Optical Fiber Sensing and Communications, Department of Optoelectronic Engineering, College of Science and Engineering, Jinan University, Guangzhou 510632, China Department of Ultrasonography, Hangzhou Women’s Hospital, Hangzhou, Zhejiang, China Department of Neurosurgery, Shenzhen Key Laboratory of Neurosurgery, the First Affiliated Hospital of Shenzhen University, Shenzhen Second People’s Hospital, 3002# Sungang Road, Futian District, Shenzhen 518035, China Department of Radiation Oncology, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou 510060, People's Republic of China Department of Vascular/Interventional Radiology, Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Suzhou, P.R. China. College of Animal Science and Veterinary Medicine; Shandong Agricultural University; Taian 271018; China Key Laboratory of Preparation and Applications of Environmental Friendly Materials, Jilin Normal University, Ministry of Education, Changchun 130103, P. R. China Tianjin University Eastern Hepatobiliary Surgery Hospital,Second Military Medical University,Shanghai,P.R. China; International Co‐operation Laboratory on Signal Transduction,Eastern Hepatobiliary Surgery Institute,Second Military Medical University,Shanghai,P.R. China Institute of Chinese Sturgeon, China Three Gorges Corporation, Yichang, China and; Hubei Key Laboratory of Three Gorges Project for Conservation of Fishes, Institute of Chinese Sturgeon, China Three Gorges Corporation, Yichang, China Division of Vital Statistics, Institute of Health Information, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China College of Pharmaceuticals and Biotechnology, Tianjin University, Tianjin 300072, China State Key Laboratory for Modification of Chemical Fibers and Polymer Materials; Donghua University; Shanghai 200051, China School of Material Science and Engineering; Jiangsu University of Science and Technology; Zhenjiang 212003; P. R. China; School of Environmental and Chemical Engineering Department of Plant Biology and Ecology, College of Life Science Nankai University, Tianjin 300071 China Institute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University School of Chemical Engineering & Technology, Tianjin University, Tianjin 300072, P.R. China; Key Laboratory of Systems Bioengineering, Ministry of Education of China, Tianjin 300072, P.R. China Abbott Laboratories Trading ( Shanghai) Co, . Ltd. , Shanghai 200233, China. School of Ecology and Environment, Northwestern Polytechnical University 710072 Xi’an, China Guangdong Provincial Key Laboratory of Biotechnology for Plant Development, School of Life Sciences South China Normal University Guangzhou 510631 China; Shenzhen Institute of Molecular Crop Design Shenzhen 518107 China Department of Chemistry; Stony Brook University; Stony Brook; USA School of Pharmaceutical Science and Technology, Tianjin University, Tianjin, China Department of Neurosurgery, Renji Hospital, Shanghai Jiaotong University Medical College, Shanghai, China Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangzhou, People’s Republic of China, Shandong Provincial Key Laboratory of Biomass Gasification Technology, Energy Institute, Qilu University of Technology (Shandong Academy of Sciences), 19 Keyuan Road, Jinan 250014, China Division of Pulmonary Diseases, State Key Laboratory of Biotherapy of China Department of Respiratory and Critical Care Medicine West China Hospital of Sichuan University Chengdu China Soybean Research Institute, Nanjing Agricultural University; National Center for Soybean Improvement; National Key Laboratory of Crop Genetics and Germplasm Enhancement Faculty of Environmental and Life Sciences, Beijing University of Technology , Beijing 100124 , China Department of Pharmacology, School of Pharmacy, Bengbu Medical College, Bengbu 233030, China; Anhui Engineering Technology Research Center of Biochemical Pharmaceutical, Bengbu 233030, China Institute of Chinese Sturgeon, China Three Gorges Corporation, Yichang, Hubei, China and; Hubei Key Laboratory of Three Gorges Project for Conservation of Fishes, Institute of Chinese Sturgeon, China Three Gorges Corporation, Yichang, Hubei, China Department of Pathology and Laboratory Medicine, The University of Health Science Center at Houston, Houston, TX, USA; Department of Laboratory Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA From the Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia. Department of Pharmacy, Henan Medical College, Zhengzhou 451191, China Department of Chemistry and Biochemistry, Queens College and the Graduate Center of the City University of New York, Flushing, New York 11367, United States Department of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China Department of Gastroenterology, Northern Jiangsu People's Hospital, Clinical Medical College of Yangzhou University, Yangzhou, P.R. China. Institute of Functional Nano and Soft Materials (FUNSOM), Soochow University, Suzhou 215123, China Institute of Quality Standard and Testing Technology for Agro-Products, Shanghai Academy of Agricultural Sciences, Shanghai 201403, China Department of Radiation Oncology, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in Southern China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, People's Republic of China Department of Stomatology Jinan Military General HospitalJinan 250000, China; Department of Orthodontics, Jinan Stomatological HospitalNo. 101, Jing Liu Road, Jinan 250001, China. Hefei Innovation Research Institute of Beihang University, Beijing, Anhui230012, China Division of Pulmonary Diseases State Key Laboratory of Biotherapy of China Department of Respiratory Medicine West China Hospital of Sichuan University Chengdu China School of Chemistry and Chemical Engineering Shandong University Jinan 250100 P. R. China Institute of Neuroscience, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Medical College, University of South China, Hengyang 421001, Hunan, P. R. China; Department of Neurology, Nanhua Affiliated Hospital, University of South China, Hengyang 421001, Hunan, P. R. China Department of Gynaecology and Obstetrics, Naval General Hospital, Beijing 100037, China. chenleis@mail.tsinghua.edu.cn Department of Plant Biology and Ecology, College of Life Science Nankai University Tianjin China College of Chemical Engineering; North China University of Science and Technology; Tangshan Hebei 063009 China Department of Vascular Surgery, Fuxing Hospital Affiliated to Capital Medical University, Beijing, P. R. China. Department of Neurology, Xiangya Hospital, Central South University College of Information Engineering, Shanghai Maritime University, Shanghai 201306, P. R. China Nanjing Regenerative Medicine Engineering and Technology Research Center, Nanjing 210046, China School of Chinese Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China. School of Environmental and Chemical Engineering; Jiangsu University of Science and Technology; Zhenjiang 212003; China College of Veterinary Medicine of Sichuan Agricultural University, Ya'an 625014, China. morn_chen@126.com Laboratory of Synthetic Microbiology, School of Chemical Engineering & Technology, Tianjin University, Tianjin, P.R. China;; Key Laboratory of Systems Bioengineering, Ministry of Education of China, Tianjin, P.R. China;; SynBio Platform, Collaborative Innovation Center of Chemical Science and Engineering, Tianjin, P.R. China Department of Hematopathology, The University of Texas M. D. Anderson Cancer Center, Houston State Key Laboratory of Tribology; Tsinghua University; Beijing; China Invasive Technology Department The Affiliated Suzhou Hospital of Nanjing Medical University Jiangsu Suzhou 215101 P. R. China College of Food Science, Fujian Agriculture and Forestry University, Fuzhou, Fujian 350002, P.R. China. Department of Ultrasound in Medicine, Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University, Shanghai 200233, P.R. China Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan 430022 China The Molecular Biology Centre, State Key Laboratory of Trauma Burn and Combined Injury, Research Institute of Surgery and Daping Hospital, Third Military Medical University, Chongqing, China and From the *Department of Public Health, Wuxi Center for Disease Control and Prevention, Wuxi, China; †Department of Medical Statistics and Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou, China; and ‡Department of Sexually Transmitted Infections Control, Dermatology Hospital of Southern Medical University, Guangzhou, China State Key Laboratory of Marine Environmental Science, Key Laboratory of the Ministry of Education for Coastal and Wetland Ecosystem, College of the Environment and Ecology, Xiamen University, Xiamen 361005, China School of Life Sciences, Qufu Normal University, Qufu 273165, China Department of Radiation Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center, Guangzhou, People's Republic of China Novartis Pharmaceuticals Corporation, East Hanover, NJ, USA; Oregon State University Department of Chemistry, , Corvallis, Oregon 97331, USA University of Kentucky 3 Department of Neurosurgery, , Lexington, Kentucky 40536, USA Department of Cardiovascular Surgery of the First Affiliated Hospital & Institute for Cardiovascular Science, Suzhou Medical College, Soochow University, Suzhou 215006, China Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 The Ministry of Education Key Laboratory of Laboratory Medical Diagnostics, College of Laboratory Medicine, Chongqing Medical University, Chongqing, China. 4ADC Therapeutics America Inc, Murray Hill, NJ National Research Center for High-Efficiency Grinding, College of Mechanical and Vehicle Engineering, Hunan University, Changsha 410082, P. R. China School of Pharmacy Gannan Medical University No. 1 Medical College Road, Zhanggong District Ganzhou 341000 China Department of Radiology, Southwest Hospital, Army Medical University , Chongqing , 400038 , China *Department of Pharmacology, College of Physicians and Surgeons of Columbia University, New York, NY 10032; and CAS Engineering Laboratory for Nanozyme, Key Laboratory of Protein and Peptide Pharmaceutical, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China; Department of Pharmacology, School of Medicine, Institute of Translational Medicine, Yangzhou University, Yangzhou 225001, Jiangsu, China Department of Ophthalmology, The First Hospital of China Medical University, Shenyang 110001, China Chongqing Academy of Animal Sciences, Chongqing 402460, China. Department of Biomedical Engineering College of Engineering Southern University of Science and Technology Shenzhen 518055 P. R. China State Key Laboratory of Oral Diseases; West China Hospital of Stomatology; Sichuan University; China Institute of Electronic Engineering; China Academy of Engineering Physics; Mianyang; China Departments of Leprosy Control, The Dermatology Hospital, Southern Medical University, Guangzhou, China, Division of Medicine, West China Hospital of Sichuan University, Sichuan, Chengdu, China Institute of Ensiling and Processing of Grass; Nanjing Agricultural University; Nanjing 210095 China Key Laboratory of Magnetic Resonance in Biological Systems State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics Wuhan Institute of Physics and MathematicsChinese Academy of SciencesInnovation Academy for Precision Measurement Science and Technology Wuhan P.R. China Department of Thoracic Surgery Chinese People's Liberation Army General Hospital Beijing China School of Chemistry and Chemical Engineering Nanjing University of Science and Technology Nanjing 210094 P. R. China Department of Pediatrics, Center for Gene Therapy, The Abigail Wexner Research Institute, Nationwide Children’s Hospital, Columbus, OH 43205, USA Sichuan Key Laboratory of Conservation Biology on Endangered Wildlife, College of Life Sciences, Sichuan University, Chengdu 610065, China Beijing Key Laboratory of Intelligent Space Robotic Systems Technology and Applications, Beijing Institute of Spacecraft System Engineering, Beijing 100094, China Key Laboratory of Preparation and Applications of Environmental Friendly Materials (Jilin Normal University); Ministry of Education; Changchun 130103; P.R. China Department of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. School of Life Sciences, Jiangsu Normal University, Xuzhou 221116, Jiangsu, China Center for Nanoscale Science and Technology, Physical Measurement Laboratory, National Institute of Standards and Technology (NIST), Gaithersburg, Maryland20899, United States Department of Hematology, Tianjin Medical University General Hospital, Tianjin, People’s Republic of China Department of Radiation Oncology Sun Yat‐sen University Cancer Center State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Guangzhou China Department of Epidemiology and Preventive Medicine, Monash University Department of Ophthalmology, The First Affiliated Hospital of China Medical University, Shenyang 110001, China Key Laboratory of Vegetation Restoration and Management of Degraded Ecosystems Provincial Key Laboratory of Applied Botany South China Botanical Garden Chinese Academy of Sciences Guangzhou 510650 China; Graduate School of Environmental Science Hokkaido University N19W8 Sapporo 060‐0819 Japan State Key Laboratory of Crop Biology, Shandong Agricultural University, Tai’an, China Department of Food Science and Engineering, Jinan University, Guangzhou 510632, China College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu, People’s Republic of China Jinan University; Jinani University 1Department of Neurosurgery, Southern Medical University, Guangzhou, China. Department of Emergency Medicine, Xiang’an Hospital of Xiamen University, Xiamen, Fujian, China Shanghai Maritime University College of Information Engineering Shanghai China State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics Chinese Academy of Sciences Shanghai 200050 China; Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of Sciences Beijing 100049 China Department of Cardiovascular Surgery, Beijing Aortic Disease Center, Beijing Anzhen Hospital, Capital Medical University, Beijing, China;; Beijing Institute of Heart Lung and Blood Vessel Diseases, Beijing Engineering Research Center for Vascular Prostheses, Beijing, China; Cancer Hospital of Shantou University Medical College, Guangdong Province, People's Republic of China Shandong Academy of Pharmaceutical Sciences Jinan, Shandong, China. Key Laboratory of the Ministry of Education for Coastal and Wetland Ecosystems College of the Environment and Ecology Xiamen University Xiamen China Department of Physiology Nanjing Medical University Nanjing China Department of Orthopedics, Tongji Hospital, School of Medicine, Tongji University, Shanghai 200065, P.R. China International Cooperation Laboratory on Signal Transduction, Eastern Hepatobiliary Surgery Hospital/National Center for Liver Cancer , Shanghai 200438 , PR. China; Key Laboratory of Signaling Regulation and Targeting Therapy of Liver Cancer (SMMU), Ministry of Education . Shanghai 200438 , PR. China; Shanghai Key Laboratory of Hepatobiliary Tumor Biology (EHBH) , Shanghai 200438 , PR. China The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, China College of Environment & Resource Sciences, Zhejiang University, Hangzhou 310058, P. R. China Department of Neurology, West China Hospital Sichuan University No. 37 Guo Xue Road Chengdu Sichuan 610041 China Institute of Gastroenterology, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, P.R. China Department of Pain Medicine, The First Affiliated Hospital Zhejiang University School of Medicine Hangzhou China Department of Neurology, Western China Hospital, Sichuan University, Chengdu, China Department of Orthodontics, Jinan Stomatological Hospital, Jinan, China. Chongqing Academy of Animal Science, Chongqing 402460, China Department of Neurosurgery The Fifth Affiliated Hospital of Sun Yat‐sen University Zhuhai Guangdong China; Guangdong Provincial Key Laboratory of Biomedical Imaging, The Fifth Affiliated Hospital Sun Yat‐sen University Zhuhai Guangdong China; Guangdong Provincial Engineering Research Center of Molecular Imaging, The Fifth Affiliated Hospital Sun Yat‐sen University Zhuhai Guangdong China College of Food Science and Technology Huazhong Agriculture University Wuhan China Department of Stomatology, Jinan Military General Hospital Number 25, Shi Fan Lu, Jinan City 250031, Shandong Province, China ; Department of Orthodontics, Jinan Stomatological Hospital Number 101, Jing Liu Road, Jinan City 250001, Shandong Province, China. Institute of Combined Injury, State Key Laboratory of Trauma, Burns and Combined Injury, Chongqing Engineering Research Center for Nanomedicine, College of Preventive Medicine Third Military Medical University 30 Gaotanyan Road Chongqing 400038 China State Key Laboratory of Chemical Biology and Drug Discovery Department of Applied Biology and Chemical Technology Hong Kong Polytechnic University Hung Hom Hong Kong SAR 999077 P. R. China; Laboratory for Synthetic Chemistry and Chemical Biology Limited Hong Kong Science and Technology Park New Territories Hong Kong SAR 999077 P. R. China Key Laboratory for Molecular Enzymology and Engineering of the Ministry of Education, College of Life Sciences Jilin University Changchun China Ningbo University, China Department of Immunology, Genetics and Pathology Uppsala University and Science for Life Laboratory, Rudbeck Laboratory Uppsala Sweden State Key Laboratory of Genetic Resources & Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming Yunnan 650223, China;University of Chinese Academy of Sciences, Beijing 100049, China. Biotherapeutics, Biocytogen Jiangsu Co. Ltd , Nantong, China; Biotherapeutics, Biocytogen Pharmaceuticals (Beijing) Co, Ltd , Beijing, China Engineering Center of Catalysis and Synthesis for Chiral Molecules Departments of Psychiatry and Neuroscience, Center for Molecular Biology and Genetics of Neurodegeneration, Icahn School of Medicine at Mount Sinai, New York, NY, USA Institute of Functional Nano and Soft Materials (FUNSOM), Soochow University, Suzhou 215123, People’s Republic of China School of Civil Engineering of Nanjing Forestry University, Longpan Road 159, Nanjing 210037, China; Key Laboratory of Water Pollution Control and Environmental Safety of Zhejiang Province, Hangzhou, China; Jiangsu Provincial Key Laboratory of Environmental Science and Engineering, Suzhou University of Science and Technology, Suzhou 215009, China Department of Ophthalmology, The First Hospital of China Medical University, Shenyang 110001, China; Key Laboratory of Endocrine Diseases of Liaoning Province, The First Hospital of China Medical University, Shenyang 110001, China Department of Urology, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine. The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. Guangzhou Medical College, Guangzhou, Guangdong 510182, China; Department of Orthopedics, Second People’s Hospital of Shenzhen, Sungang West Road, Futian District, Shenzhen, Guangdong 518035, China; Shenzhen Key Laboratory of Tissue Engineering, Shenzhen, Guangdong 518035, China State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China; University of Chinese Academy of Sciences, Beijing, China Department of Neurology and Research Center of Neurology in Second Affiliated Hospital, and Key Laboratory of Medical Neurobiology of Zhejiang Province, Zhejiang University School of Medicine, 310009, Hangzhou, China Department of Entomology, Nanjing Agricultural University, Nanjing, Jiangsu, China Department of Intervention and Vascular Surgery, Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, Jiangsu 215001, P.R. China Department of General Surgery, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China Department of Pharmacy, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, People’s Republic of China Center for Molecular Imaging and Nuclear Medicine, State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X), Soochow University, Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions, Suzhou 215123, China Savaid Medical School, University of Chinese Academy of Sciences, Beijing 101400, China The People’s Hospital of Pu Dong New Area, Chuansha New Town, Shanghai, People’s Republic of China Key Laboratory of Biotechnology and Bioengineering of State Ethnic Affairs Commission, Biomedical Research Center, Northwest Minzu University, Lanzhou 730030, China Key Laboratory of Preparation and Applications of Environmental Friendly Materials, Ministry of Education, Jilin Normal University, Siping, China The Second Clinical College, Chongqing Medical University, Chongqing 400016, China Pancreas Center The First Affiliated Hospital of Nanjing Medical University Nanjing China; Pancreas Institute Nanjing Medical University Nanjing China Jiangsu Carephar Pharmaceutical Co., Ltd, Nanjing 210014, China State Key Laboratory for Powder Metallurgy, Central South University, Changsha 410083, China Department of Urinary Surgery, Zhuzhou Central Hospital, Zhuzhou, Hunan 412000, P.R. China Eli Lilly and Company Indianapolis Indiana College of Life Sciences Qufu Normal University Qufu Shandong China Department of Neurology, the Affiliated Nanhua Hospital; Institute of Neuroscience, Hengyang Medical College College of Bioscience and Biotechnology, Yangzhou University, Yangzhou, Jiangsu 225009, China Department of Chemistry and Chemical Biology; Cornell University; Ithaca; USA Department of Burns, The 1st Affiliated Hospital of Sun Yat-sen University 58 2nd Zhongshan Road, Guangzhou 510080, Guangdong, P. R. China. Department of Anesthesia, First Affiliated Hospital, Jinan University, Guangzhou 510632, China.E-mail: chenleixm@163.com. 2ADC Therapeutics, New Providence, NJ Mechanical Engineering, University of Massachusetts Lowell, Lowell, MA, USA State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry, Jilin University, Changchun 130012, P. R. China, and State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Institute of Physics and Mathematics, The Chinese Academy of Sciences, Wuhan 430071, P. R. China Department of Urology Shanghai General Hospital Shanghai China School of Chemistry and Chemical Engineering; State Key Laboratory of Urban Water Resource and Environment; Harbin Institute of Technology; Harbin; China College of Otolaryngology Head and Neck Surgery Chinese PLA General Hospital, Chinese PLA Medical School Beijing China Department of Physiology Qingdao University Qingdao China The First Affiliated Hospital of Wenzhou University, Wenzhou 325000, Zhejiang, China; wmugk@outlook.com. Institute of Nutrition & Health, Qingdao University, Qingdao, China; School of Public health, Qingdao University, Qingdao, China The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang, China; chenlei689595@gmail.com. Department of Neurosurgery, The Fifth Central Hospital of Tianjin, Tianjin, China (mainland) Center for Microbiota and Immunological Diseases, Shanghai General Hospital, Shanghai Institute of Immunology, Shanghai Jiao Tong University, School of Medicine, Shanghai 2,000,025, China Vollum Institute, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA. R&D Department, Nanjing Regenerative Medicine Engineering and Technology Research Center, Nanjing, Jiangsu 210046, P.R. China State Key Joint Laboratory of Environment Simulation and Pollution Control, School of Environment, Tsinghua University, Beijing 100084, China; State Environmental Protection Key Laboratory of Sources and Control of Air Pollution Complex, Beijing 100084, China Department of Oncology, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215004, P.R. China Department of Pathology School of Basic Medical Sciences Fudan University Shanghai China From the Departments of Cytopathology (Drs Chen and Schnadig) and Radiology (Dr Walser), The University of Texas Medical Branch at Galveston The International Peace Maternity and Child Health Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China Department of Otolaryngology, The Second Hospital of Tianjin Medical University, Tianjin 300211, P.R. China State Key Laboratory for Conservation and Utilization of Subtropical Agrobio‐resources/Key Laboratory of Biology and Genetic Improvement of Horticultural Crops (South China), Ministry of Agriculture and Rural Affairs/Guangdong Litchi Engineering Research Center, College of Horticulture South China Agricultural University Guangzhou China Department of Urology, Longhua Hospital, Shanghai University of Traditiond Chinese Medicine, Shanghai 200032, China. School of Life Science and Biotechnology Dalian University of Technology Dalian P. R. China Innovative Research Center of Medicine, Key Laboratory of Macromolecular Science of Shaanxi Province, School of Chemistry and Chemical Engineering, Shaanxi Normal University, Chang’an Campus No. 620, West Chang’an Avenue, Chang’an District, Xi’an 710119, China Hunan Engineering Technology Research Center of Featured Aquatic Resources Utilization, Hunan Agricultural University, Changsha, PR China Key Laboratory of Science and Technology on Wear and Protection of Materials State Key Laboratory of Solid Lubrication Lanzhou Institute of Chemical Physics Chinese Academy of Sciences Lanzhou 730000 China; Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of Sciences Beijing 100049 China School of Energy and Power Engineering, Qilu University of Technology (Shandong Academy of Sciences) Jinan China Laboratory of Heat and Mass Transport at Micro-Nano Scale, College of Engineering, Peking University, and Key Lab of Theory and Technology for Advanced Batteries Materials, Beijing 100871, China Department of Hematology, Hospital Affiliated to Weifang Medical University, Weifang 261031, China. College of Animal Science and Technology Northwest A&F University Yangling Shaanxi 712100 China National Engineering Research Center for Urban Water Resources; Shanghai 200082; P. R. China College of Food and Bioengineering, Henan University of Science and Technology, Luoyang, China Technology Development Department, Shanghai Central Meteorological Observation, Shanghai, China Department of Burns, Laboratory of General Surgery The First Affiliated Hospital of Sun Yat‐Sen University Guangzhou Guangdong China; Guangdong Provincial Engineering Technology Research Center of Burn and Wound Accurate Diagnosis and Treatment Key Technology and Series of Products Sun Yat‐Sen University Guangzhou Guangdong China; Institute of Precision Medicine, The First Affiliated Hospital Sun Yat‐Sen University Guangzhou Guangdong China Department of Anesthesiology, Zhongnan Hospital of Wuhan University, 169, Donghu Road, Wuhan, 430071 Hubei, China Department of Otolaryngology,Changyuan Hospital of Traditional Chinese Medicine. Department of Hematology, The Hospital Affiliated to Weifang Medical University, Weifang, Shandong 261053, P.R. China School of Pharmaceutical Sciences, China Medical University, Shenyang 110001, China State Key Laboratory of Water Environment Simulation; School of Environment; Beijing Normal University; Beijing; China 100875 Shanxi Institute of Medicine and Life Science Taiyuan P. R. China Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China; Hubei Provinve Key Laboratory of Molecular Imaging, Wuhan 430022, China Division of Emergency Medicine, Department of Pediatrics, Yale University School of Medicine, CT State Key Laboratory of Natural Medicines, School of Science, China Pharmaceutical University, Nanjing 210009, P.R. China Department of Obstetrics and Gynecology The Sixth Medical Center of PLA General Hospital Beijing China Molecular Oncology Laboratory, the Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China; Anhui Province Key Laboratory of Genitourinary Diseases, Anhui Medical University, Hefei 230022, China; Institute of Urology, Anhui Medical University, Hefei 230022, China Department of Radiation Oncology State Key Laboratory of Oncology in Southern China Collaborative Innovation Center for Cancer Medicine Sun Yat‐sen University Cancer Center Guangzhou China Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangzhou, People’s Republic of China Department of Materials Science and Engineering, Pennsylvania State University, University Park, Pennsylvania 16802, United States Key Laboratory of Ethnomedicine for Ministry of Education, Center on Translational Neuroscience, College of Life and Environmental Sciences, Minzu University of China, Haidian District, Beijing, China Analysis Group, Boston, MA, USA MOE Key Laboratory of Protein Sciences and Tsinghua‐Peking Center for Life Sciences School of Life Sciences Tsinghua University Beijing China College of Chemistry and Chemical Engineering Institute of Physical Science and Information Technology Anhui University and Key Laboratory of Functional Inorganic Materials Chemistry of Anhui Province Anhui Province Key Laboratory of Chemistry for Inorganic/Organic Hybrid Functionalized Materials Key Laboratory of Structure and Functional Regulation of Hybrid Materials (Anhui University) Ministry of Education Hefei 230601 P. R. China State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, P.R. China. Beijing Aortic Disease Center, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing Anzhen Hospital, Capital Medical University, Beijing, China National Institute for Advanced Materials School of Materials Science and Engineering Smart Sensing Interdisciplinary Science Center Nankai University Tianjin 300350 China Department of Pathology XinHua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai China International Cooperation Laboratory on Signal Transduction, Eastern Hepatobiliary Surgery Institute The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei‐MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology Wuhan University Wuhan China Department of Entomology Nanjing Agricultural University Nanjing China Department of Anesthesiology, Fuwai Hospital, Chinese Academy of Medical Science, Beijing, People’s Republic of China Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, China State Key Laboratory of Analytical Chemistry for Life Sciences; School of Chemistry and Chemical Engineering; Nanjing University; Nanjing 210023; China The National Key Clinic SpecialtyThe Neurosurgery Institute of Guangdong Province, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Department of Neurosurgery, Zhujiang Hospital, Southern Medical University, Guangzhou, China Longhua Hospital, Shanghai University of Chinese Medicine, Shanghai 200032, China. Wright Center for Photovoltaics Innovation and Commercialization Department of Physics and Astronomy University of Toledo 2801 W Bancroft St Toledo OH 43606 USA Nanjing Institute for Comprehensive Utilization of Wild Plant, Nanjing 210042, China 1Division of Hematology/Oncology, Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University, 199 Ren’ai Road, Suzhou, 215123 Jiangsu, PR China South China Advanced Institute for Soft Matter Science and Technology, School of Molecular Science and Engineering, Guangdong Provincial Key Laboratory of Functional and Intelligent Hybrid Materials and Devices, South China University of Technology, Guangzhou 510640, China Department of Cardiovascular Surgery, The First Medical Center of Chinese PLA General Hospital, Beijing 100853, China School of Physics and ‡School of Material Science and Engineering, South China University of Technology, Guangzhou 510640, P. R. China Tulane University; Southeast Louisiana Veterans Health Care System, New Orleans, LA; Novartis Pharmaceuticals Corporation, East Hanover, NJ; and Analysis Group, Boston, MA Chongqing Engineering Research Center of Biomaterial Fiber and Modern Textile, College of Textile and Garment, Southwest University, Chongqing 400715, China The third Clinical College, Southern Medical University, Guangzhou 510515, China; Department of gynaecology and obstetrics, PLA Navy General Hospital, Beijing 100037, China Department of Social Welfare, Luskin School of Public Affairs, University of California, Los Angeles, Los Angeles, CA Sichuan XuHang New Materials Co., Ltd., Chengdu 610500, China Nankai University Key Laboratory of Optical Information Science and Technology, Ministry of Education, Institute of Modern Optics, , Tianjin 300071, China Department of Animal ScienceSouthwest University Chongqing China Department of Endocrinology, Suzhou Municipal Hospital Affiliated to Nanjing Medical University; Suzhou 215002, China.*Corresponding author, E-mail: szlei2004@163.com. School of Ecology and Environment, Northwestern Polytechnical University , Xi’an, Shaanxi 710072 , China College of Life and Environmental Sciences, Minzu University of China, Beijing, China College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China Center of Pancreas, The First Affiliated Hospital to Nanjing Medical University, Nanjing, Jiangsu, China; Pancreas Institute, The First Affiliated Hospital to Nanjing Medical University, Nanjing, Jiangsu, China Guangdong Provincial Key Laboratory of Chiral Molecules and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China Department of Chemistry, Collaborative Innovation Center of Chemistry for Energy Materials, State Key Laboratory of Molecular Engineering of Polymers, Fudan University, Shanghai 200433, People’s Republic of China Department of Urinary Surgery, Central Hospital of Zhuzhou, Zhuzhou, Hunan 412000, P.R. China Center for Nanoscale Science and Technology, National Institute of Standards and Technology, Gaithersburg, Maryland 20899, United States School of Materials and Energy, Guangdong University of Technology, Guangzhou 510006, China From the Departments of Pathology (Drs Chen and Haque) and Obstetrics and Gynecology (Dr Dinh), The University of Texas Medical Branch, Galveston College of Landscape Architecture, Fujian Agriculture and Forestry University, Fuzhou, Fujian, China Department of AnesthesiologyThe First Affiliated HospitalJinan University Guangzhou China Department of Immunotherapy and Gastrointestinal Oncology Affiliated Cancer Hospital of Shantou University Medical College Shantou Guangdong China Anhui Province Key Laboratory of Clinical and Preclinical Research in Respiratory Disease, Molecular Diagnosis Center Key Laboratory of Advanced Energy Materials Chemistry (Ministry of Education), National Institute for Advanced Materials, School of Materials Science and Engineering, Nankai University, Tianjin 300350, China Department of Molecular Oncology, Eastern Hepatobiliary Surgical Hospital and National Center for Liver Cancer Navy Military Medical University Shanghai China School of Electronic Information Engineering, Beihang University, Beijing 100191, China. radiumchen@sina.com Southwest Medical University, Luzhou 646000, Sichuan, China Department of Neurology, Joint Research Institution of Altitude Health, State Key Laboratory of Biotherapy and Cancer Center, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China International Co‐operation Laboratory on Signal Transduction Eastern Hepatobiliary Surgery Institute Second Military Medical University Shanghai China Health Sciences Institute, China Medical University, Shenyang, Liaoning Province, People’s Republic of China; School of Life Sciences, China Medical University, Shenyang, Liaoning Province, People’s Republic of China; Liaoning Key Laboratory of Obesity and Glucose/Lipid Associated Metabolic Diseases, China Medical University, Shenyang, Liaoning Province, People’s Republic of China Shanghai Institute of Immunology Shanghai Jiao Tong University School of Medicine Shanghai PR China The Key Laboratory of industrial Biotechnology Ministry of Education; School of Biotechnology; Jiangnan University; Wuxi 214122; China SEU-FEI Nano-Pico Center; Key Laboratory of MEMS of Ministry of Education; Collaborative Innovation Center for Micro/Nano Fabrication; Device and System; Southeast University Department of Research and Development,Shenzhen Institute for Innovation and Translational Medicine,Shenzhen International Biological Valley‐Life Science Industrial Park,Shenzhen,China Department of Vascular Surgery, Zhejiang Provincial People's Hospital, Hangzhou City, Zhejiang Province, China. Department of Chemistry, State Key Laboratory of Molecular Engineering of Polymers, Fudan University, Shanghai 200433, China Department of Research and Development, Shenzhen Institute for Innovation and Translational Medicine, Shenzhen International Biological Valley-Life Science Industrial Park, Dapeng New District, Shenzhen, China Department of Orthopedic Surgery, West China Hospital, Sichuan University, Chengdu Sichuan, P.R. China 610041. School of Information and Electrical Engineering, Hunan University of Science and Technology, Xiangtan, China Baker IDI Heart and Diabetes Institute, Melbourne, Australia Department of Haematology Liaocheng People's Hospital Liaocheng Shandong Province China Chinese Pharmacopoeia Commission, Beijing, 100061. Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China Department of Pharmacology, School of Pharmaceutical Sciences, Central South University, Changsha 410078, P.R. China. School of Chemistry and Chemical Engineering, Nanjing University, 210023 Nanjing, China Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in Southern China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, People's Republic of China State Key Laboratory of Vegetation and Environmental Change, Institute of Botany, the Chinese Academy of Sciences, 100093 Beijing, China State Key Laboratory of Supramolecular Structure and Materials, Jilin University, Changchun 130012, P. R. China, and Department of Chemistry, School of Science and Technology, Kwansei Gakuin University, Sanda, Hyogo 669-1337, Japan International Co-operation Laboratory on Signal Transduction; Eastern Hepatobiliary Surgery Institute, Second Military Medical University; Shanghai China Department of Pathology and Laboratory Medicine Health Sciences Center at Houston McGovern Medical School at Houston The University of Texas Houston TX USA State Key Laboratory of Veterinary Etiological Biology, Key Laboratory of Veterinary Parasitology of Gansu Province, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu, P.R. China. Key Laboratory of Preparation and Applications of Environmental Friendly Materials (Jilin Normal University), Ministry of Education, Changchun, 130103, China Jilin University 1 State Key Laboratory of Supramolecular Structure and Materials, Institute of Theoretical Chemistry, , Changchun 130012, People’s Republic of China; Jilin University 2 College of Physics, , Changchun 130012, People’s Republic of China Department of Research Center, Dermatology Hospital, Southern Medical University/Guangdong Provincial Dermatology Hospital Department of Pharmacy, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China; Laboratory of Clinical Pharmacy and Adverse Drug Reaction, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China Department of Ophthalmology, Children's Hospital of Soochow University, Suzhou 215025, Jiangsu Province, China. College of Mechanical and Vehicle Engineering, National Engineering Research Center for High-Efficiency Grinding, Hunan University, Changsha410082, China Department of Respiratory and Critical Care Medicine, West China Hospital of Sichuan University and Division of Pulmonary Diseases, State Key Laboratory of Biotherapy of China, Chengdu 610041, China Department of Pathology and Laboratory Medicine, The University of Texas McGovern Medical School, Houston, TX Center for Ecological and Environmental Sciences, Key Laboratory for Space Bioscience and Biotechnology, Northwestern Polytechnical University, Xi’an, 710072, China College of Food Science, Fujian Agriculture and Forestry University, Fuzhou, Fujian, China Department of Critical Care Nephrology and Blood Purification The First Affiliated Hospital of Xi'an Jiaotong University Xi'an Shannxi China Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology; Hubei Province Key Laboratory of Molecular Imaging, Wuhan, China Key Laboratory of Functional Materials Physics and Chemistry, Jilin Normal University, Ministry of Education, Siping 136000, PR China Department of Urology, The Second Hospital of Anhui Medical University, Hefei, Anhui 230601, P.R. China State Key Laboratory of Plant Physiology and Biochemistry College of Life Sciences Zhejiang University Hangzhou 310058 China Department of Physiology, Nanjing Medical University, Nanjing, P.R. China Department of Otorhinolaryngology Head and Neck Surgery, Tianjin Medical University Second Hospital, Tianjin, P. R. China Department of Physics; South China University of Technology; Guangzhou; P. R. China Department of Radiology Peking University People's Hospital Beijing P.R. China Department of Neurology and Research Center of Neurology in Second Affiliated Hospital, and Key Laboratory of Medical Neurobiology of Zhejiang Province Zhejiang University School of Medicine Hangzhou China Department of Pediatrics, Section of Pediatric Emergency Medicine, Yale University School of Medicine, New Haven, Connecticut Department of Neurosurgery, The First People’s Hospital of Shizuishan, Shizuishan, Ningxia Hui Autonomous Region, China Department of Orthopaedics; The First Affiliated Hospital of Wenzhou Medical University; Wenzhou 325000; China Center for Molecular Imaging and Nuclear Medicine State Key Laboratory of Radiation Medicine and Protection School for Radiological and Interdisciplinary Sciences (RAD‐X) Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions Soochow University Suzhou 215123 China Institute of Functional Nano & Soft Materials (FUNSOM), Collaborative Innovation Center of Suzhou Nano Science and Technology (NANO-CIC), Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University, Suzhou, Jiangsu 215123, P. R. China Shaanxi Guoren Fungi Science and Technology Industrial Park Co. Ltd Baoji China School of Life Science and Biotechnology, Dalian University of Technology, Dalian 116024, China Shenzhen Hospital of Guangzhou University of Chinese Medicine, Shenzhen, Guangdong 518034,China Department of Neurosurgery, Tangdu Hospital, Fourth Military Medical University, Xi'an, China; Key Laboratory of Applied Chemistry of Chongqing Municipality, and Chongqing Key Laboratory of Soft-Matter Material Chemistry and Function Manufacturing, School of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, China Department of Physics South China University of Technology Guangzhou 510641 China; South China Institute of Collaborative Innovation Dongguan 523808 P. R. China College of Food Science and Technology, Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety, Guangdong Province Engineering Laboratory for Marine Biological Products, Guangdong Provincial Engineering Technology Research Center of Seafood, Key Laboratory of Advanced Processing of Aquatic Product of Guangdong Higher Education Institution, Guangdong Ocean University, Zhanjiang, China Nanjing Institute for Comprehensive Utilization of Wild Plants, Nanjing 210042, P.R. China Department of General Internal Medicine, Ningbo First Hospital, Ningbo, China Department of Molecular Oncology, Eastern Hepatobiliary Surgical Hospital & National Center of Liver Cancer, Second Military Medical University, Shanghai 200438, China Key Laboratory of Pig Industry Sciences (Ministry of Agriculture), Chongqing Academy of Animal Science , Chongqing, China College of Food Science; Fujian Agriculture and Forestry University; Fuzhou; P. R. China Guangdong Provincial Key Laboratory of Optical Fiber Sensing and Communications, Department of Optoelectronic Engineering, Jinan University, Guangzhou 510632, China; Key Laboratory of Visible Light Communications of Guangzhou, Jinan University, Guangzhou 510632, China; Key Laboratory of Optoelectronic Information and Sensing Technologies of Guangdong Higher Education Institutes, Guangzhou 510632, China Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi 214122, China; National Engineering Laboratory for Cereal Fermentation Technology, Jiangnan University, Wuxi 214122, China Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China Department of Emergency Medicine, Xiang'an Hospital of Xiamen University, Xiamen, Fujian, P.R. China Department of Pharmacology, School of Medicine, Zhejiang Key Laboratory of Pathophysiology, Ningbo University, Ningbo, Zhejiang, China; Department of Psychosomatic Medicine, The First Affiliated Hospital of Ningbo Universit, Ningbo First Hospital, Ningbo, Zhejiang, China Department of Pediatric Surgery, Cangzhou Central Hospital, No.16 Xinhua West Road, Cangzhou 061000, Hebei,China Key Laboratory of Genetics, Breeding & Reproduction of Grass‐Feeding Livestock Ministry of Agriculture Urumqi China; Key Laboratory of Animal Biotechnology of Xinjiang Institute of Animal Biotechnology Xinjiang Academy of Animal Science Urumqi China The Graduate School, Xuzhou Medical University, Xuzhou, China Department of Toxicology, School of Public Health, Zunyi Medical University, Zunyi, People’s Republic of China Department of Neurology, Tianjin HuanHu Hospital, Tianjin, China Key Laboratory of Preparation and Applications of Environmental Friendly Materials, Ministry of Education, Jilin Normal University, Changchun 130103, P. R. China Research Center for Drug Discovery; School of Pharmaceutical Sciences; Sun Yat-sen University; Guangzhou 510006; People's Republic of China Rutgers, the State University of New Jersey, Department of Genetics, Human Genetics Institute of New Jersey, Piscataway, NJ, 08854, USA; Cancer Institute of New Jersey, and Human Genetics Institute of New Jersey, Piscataway, NJ, 08854, USA College of Animal Science and Technology, Shihezi University, Shihezi 832000, China Department of Chemistry, School of Science, Xi’an Key Laboratory of Sustainable Energy Material Chemistry, and MOE Key Laboratory for Nonequilibrium Synthesis and Modulation of Condensed Matter, Xi’an Jiaotong University, Xi’an 710049, P. R. China State Key Laboratory of High Performance Ceramics and Superfine Microstructure; Shanghai Institute of Ceramics; Chinese Academy of Sciences; Shanghai; China Institute of Food and Nutraceutical Science, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China Nanjing University of Science & Technology School of Materials Science and Engineering, Smart Sensing Interdisciplinary Science Center, Key Laboratory of Advanced Energy Materials Chemistry (Ministry of Education), Nankai University, Tianjin 300350, People’s Republic of China Department of Physiology, Medical College Qingdao University, Qingdao, China Tianjin Tasly Modern TCM Resources Co., Ltd, Tianjin 300410, People’s Republic of China Department of Vascular Surgery, FuXing Hospital Capital Medical University Beijing China Department of Obstetrics and Gynecology, Jiamusi Central Hospital, Jiamusi, 154002, China Department of Acupuncture, Ningbo Municipal Hospital of TCM, Affiliated Hospital of Zhejiang Chinese Medical University, Ningbo Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, VIC, Australia. School of Science, Jiangsu University of Science and Technology, Zhenjiang, 212100, China College of Food Science; Fujian Agriculture and Forestry University; Fuzhou; China Department of Pulmonology, The Affiliated Hospital of Ningbo University, 247 Renmin Road, Ningbo, Zhejiang 315020, China Department of Anatomy, histology and embryology, K. K. Leung Brain Research Centre, Fourth Military Medical University, Xi'an, 710032, China International Co-operation Laboratory on Signal Transduction (L.C., H.-X.Y., W.Y., Q.L., H.-F.C., S.-Q.L., H.-Y.W.), Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, 200438; Shanghai, People’s Republic of China Department of Neurology, Joint Research Institution of Altitude Health, West China Hospital, Sichuan University , Chengdu 610041 , China From the Departments of Burns and Emergency Surgery and Laboratory of Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, PR China Respiratory Medicine Department of Animal Science, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China; Farm Animal Genetic Resource Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, China 1Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.; 3The International Cooperation Laboratory on Signal Transduction, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China.; 4National Center for Liver Cancer, Shanghai, China. Shan Dong Provincial Key Laboratory of Storage and Transportation Safety, China University of Petroleum (East China) , Qingdao, Shandong 266580, China College of Light Industry and Food Science, South China University of Technology, Guangzhou 510640, PR China. Key Laboratory of Digital Quality Evaluation of Chinese Materia Medical of State Administration of TCM, China; Engineering & Technology Research Center for Chinese Materia Medical Quality of Guangdong Province, Guangdong Pharmaceutical University, Guangzhou, China Department of Pathology and Developmental Biology Howard Hughes Medical Institute, Stanford University Medical School Stanford California Merck & Co., Inc. Kenilworth New Jersey USA Department of Hepato-Pancreato-Biliary and Gastric Medical Oncology, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences , Hangzhou , People’s Republic of China School of Life Sciences, Anhui University Hefei PR China; Key Laboratory of Eco‐engineering and Biotechnology of Anhui Province and Anhui Key Laboratory of Modern Biomanufacturing Hefei PR China Department of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha, PR China; Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, China Sun Yat-sen University Cancer Center; State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine, Guangzhou, People's Republic of China State Key Laboratory of Membrane Biology Institute of Molecular Medicine Beijing Key Laboratory of Cardiometabolic Molecular Medicine Peking University Beijing China; Peking‐Tsinghua Center for Life Sciences Peking University Beijing China Key Laboratory of Preparation and Applications of Environmental Friendly Materials; Ministry of Education; College of Chemistry; Jilin Normal University; Siping 136000 Stomatology Centre, Xiangya Hospital, Central South University, Changsha 410008, China. Department of Surgery, Qilu Medical University, Zibo, Shandong, China College of Animal Science and Veterinary Medicine; Shandong Agricultural University; Taian 271018; China; School of Chemistry and Chemical Engineering Department of Respiratory Medicine, Affiliated Center Hospital of Shenyang Medical College, Shenyang, P. R. China Department of Neurosurgery, Affiliated Hospital of Beihua University, Jilin City, Jilin 132000, P.R. China Department of Intervention and Vascular Surgery, Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Suzhou Cancer Medical Center, Suzhou, China College of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, P. R. China; Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), Wenzhou Institute, University of Chinese Academy of Sciences, 1 Jinlian Road, Longwan District, Wenzhou 325001, P. R. China Yale University School of Medicine, New Haven, CT. International Cooperation Laboratory on Signal Transduction Eastern Hepatobiliary Surgery Institute Second Military Medical University Shanghai China State Key Joint Laboratory of Environmental Simulation and Pollution Control, School of Environment, Beijing Normal University, Beijing 100875, China; Research Center for Analytical Sciences Northeastern University Shenyang China Laboratory for Computational Sensing and Robotics, Johns Hopkins University, Baltimore, Maryland Department of Pediatric Surgery, Cangzhou Central Hospital, Cangzhou, China From The Ohio State University, Department of Neurology, Neuromuscular Disease Center, Columbus, OH. Department of Nephrology Shanghai General HospitalShanghai Jiao Tong University School of Medicine Shanghai China Guangdong Provincial Center for Skin Disease and STI Control, Guangzhou, Guangdong 510091, China School of Science, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, P. R. China Anhui Medical University, Hefei, Anhui 230032, China; Department of Gynaecology and Obstetrics, PLA Navy General Hospital, Beijing 100037, China Key Lab. Ecochem. Engin.; and Coll. Chem. Mol. Engin.; Qingdao Univ. Sci. & Tech.; P. R. China State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of Technology Wuhan 430070 P. R. China Key Laboratory of Digital Quality Evaluation of Chinese Materia Medica of State Administration of TCM, College of Traditional Chinese Materia Medica, Guangdong Pharmaceutical University, Guangzhou, China Department of Otorhinolaryngology Head and Neck Surgery Chinese PLA General Hospital Beijing China Department of Radiation Oncology Sun Yat‐sen University Cancer Center, State Key Laboratory of Oncology in Southern China, Collaborative Innovation Center for Cancer Medicine Guangzhou China College of Aerospace Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing 210016, China; State Key Laboratory of Mechanics and Control for Aerospace Structures, Nanjing 210016, China Guangdong Provincial Key Laboratory of Optical Fiber Sensing and Communications, Jinan University, Guangzhou, Guangdong 510632, China; Department of Optoelectronic Engineering, Jinan University, Guangzhou, Guangdong 510632, China Email: chen301@aliyun.com. College of Food Science Fujian Agriculture and Forestry University Fuzhou China Contribution from the State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Center for Magnetic Resonance, Wuhan Institute of Physics and Mathematics, The Chinese Academy of Sciences, Wuhan 430071, China Faculty of Environmental and Life Sciences Beijing University of Technology Beijing China Department of Mechanical Engineering University of Michigan−Dearborn Dearborn MI 48128 USA; Michigan Institute for Data Science University of Michigan Ann Arbor MI 48109 USA State Key Laboratory of Advanced Technology for Materials Synthesis and Processing; Wuhan University of Technology; Wuhan 430070; China Medical School of Chinese PLA, Beijing, China; College of Otolaryngology Head and Neck Surgery, Chinese PLA General Hospital, Beijing, China; The First Medical Center, Chinese PLA General Hospital, Beijing, China; National Clinical Research Center for Otolaryngologic Diseases, Beijing, China Research Center for Analytical Sciences, Northeastern University, Shenyang 110004, China; Department of Chemistry, Waterloo Institute for Nanotechnology, University of Waterloo, Waterloo, Ontario N2L 3G1, Canada Mechanical Engineering Department Mississippi State University 224 Carpenter building Mississippi State MS 39762 USA Department of Orthopaedics The First Affiliated Hospital of Wenzhou Medical University Zhejiang China Tianjin Key Laboratory of Organic Solar Cells and Photochemical Conversion; School of Chemistry & Chemical Engineering; Tianjin University of Technology; Tianjin 300384; P. R. China Department of Molecular Biomarkers, Merck Research Laboratories, Kenilworth, NJ 07033, USA Department of Chemistry, Rutgers University—Newark, 73 Warren Street, Newark, New Jersey 07102, United States 1The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory of Oral Biomedicine, Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, China. 1Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in Southern China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong, P. R. China. Department of Urology, The First Affiliated Hospital of Anhui Medical University Hefei 230022, Anhui, China. Depatment of Andrology, Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China. International Co-operation Laboratory on Signal Transduction, Eastern Hepatobiliary Surgery Institute, Second Military Medical University, Shanghai 200438, China Department of Cardiothoracic Surgery, The People's Hospital of Zhangqiu District, Jinan, Shandong 250000, P.R. China Center for Postdoctoral Studies, Southern Medical University, Guangzhou 510515, China. raychen89@163.com Guangxi Key Laboratory of Subtropical Bioresources Conservation and Utilization, The Key Laboratory of Ministry of Education for Microbial and Plant Genetic Engineering, and College of Life Science and Technology, Guangxi University, 100 Daxue Road, Nanning, Guangxi 530004, PR China School of Pharmaceutical Sciences; Shandong University; Jinan 250012; China Department of Nutrition and Food Hygiene, College of Public Health, Qingdao University, 308 Ningxia Road, Qingdao 266071, China Dept. of Stomatology, Xiangya Hospital, Central South University, Changsha 410008, China. Institute of Traditional Chinese Medicine in Oncology, Longhua Hospital Shanghai University of Traditional Chinese Medicine, Shanghai 200032, P.R. China State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China.; University of Chinese Academy of Sciences, Beijing, China. Northwest Institute of Nuclear Technology Department of Blood Purification, Kidney Hospital, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China Key Laboratory for Ethnomedicine for Ministry of Education, Center on Translational Neuroscience, School of Pharmacy, Minzu University of China, Beijing 100081, P. R. China Institute of Functional Nano and Soft Materials (FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices Soochow University 199 Ren'ai Road Suzhou 215000 P. R. China Department of Gastroenterology, Southwest Hospital, Third Military Medical University, Chongqing 400038, China State Key Laboratory of Radiation Medicine and Protection; School of Radiation Medicine and Protection and Interdisciplinary Sciences (RAD-X); Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions; Soochow University; Suzhou Department of Radiology Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan China; Hubei Province Key Laboratory of Molecular Imaging Wuhan China The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei‐MOST) & Key Laboratory of Oral Biomedicine Ministry of Education School & Hospital of Stomatology Wuhan University Wuhan China Department of Dermatology Artemis Medical Aesthetics Clinic Changzhou China Department of Cardiology, the Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China Tongji University Cancer Center Shanghai Tenth People's Hospital Shanghai Frontiers Science Center of Nanocatalytic Medicine School of Medicine Tongji University Shanghai 200092 P. R. China Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China Key Laboratory of Digital Quality Evaluation of Chinese Materia Medica of State Administration of TCM, Guangdong Pharmaceutical University, Guangzhou, China; Engineering & Technology Research Center for Chinese Materia Medica Quality of the Universities of Guangdong Province, Guangzhou, China Department of Burns; The First Affiliated Hospital of Sun Yat-sen University; China Department of Chemistry University of Washington Seattle WA 98195 USA Guangdong Provincial Key Laboratory of Optical Fiber Sensing and Communications, Jinan University, Guangzhou 510632, China; Department of Optoelectronic Engineering, Jinan University, Guangzhou 510632, China Key Laboratory for Deep Processing of Major Grain and Oil, Ministry of Education, Wuhan Polytechnic University, Wuhan 430023, China Department of Critical Care Nephrology and Blood Purification, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, China Key Laboratory of Vegetation Restoration and Management of Degraded Ecosystems Guangdong Provincial Key Laboratory of Applied Botany South China Botanical Garden Chinese Academy of Sciences Guangzhou China Department of Thoracic Surgery the Second Affiliated Hospital of Soochow University Suzhou China State Key Laboratory of Radiation Medicine and Protection School for Radiological and interdisciplinary Sciences (RAD-X) and Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions Soochow University Suzhou 215123 China Fert Beijing Research Institute MIIT Key Laboratory of Spintronics School of Integrated Circuit Science and Engineering Beihang University Beijing 100191 P. R. China Laboratory of Hypoxic Biomedicine, Institute of Special Environmental Medicine, Co-Innovation Center of Neuroregeneration, Nantong University, 9 Seyuan Road, Nantong 226019, China State Key Laboratory of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, P. R. China; Frontiers Science Center for New Organic Matter, College of Chemistry, Nankai University, Tianjin 300071, P. R. China Department of Pathology and Laboratory Medicine, The University of Texas Health Science Center at Houston, Houston, TX, USA College of Food Science, Fujian Agriculture and Forestry University, Fuzhou, Fujian 350002, China Department of Obstetrics and Gynecology Navy General Hospital of People Liberation Army Beijing P.R. China Department of Pathology, University of Cambridge, Cambridge, United Kingdom State Key Laboratory of Oncology in South China Department of Radiation Oncology Sun Yat‐sen University Cancer Center Guangzhou People's Republic of China Department of Ophthalmology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, P.R. China Hainan Provincial Hospital of Traditional Chinese Medicine Haikou China Mechanical Engineering University of Michigan‐Dearborn 4901 Evergreen Rd Dearborn MI 48128 USA Department of Anesthesiology, Zhongnan Hospital of Wuhan University, Wuhan, China Center for Molecular Imaging and Nuclear Medicine, State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou 215123, China Vaccine Research Center, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA. Laboratory of Synthetic Microbiology, School of Chemical Engineering & Technology, Tianjin University, Tianjin, China National Institute for the control of pharmaceutical and biological products, Beijing 100050, China Laboratory of Synthetic Microbiology, School of Chemical Engineering & Technology, and Key Laboratory of Systems Bioengineering, Ministry of Education, Tianjin University, Tianjin 300072, P. R. China Shanghai General Hospital Shanghai China Clinic for Nephrology and Critical Care Medicine, Charite-Universitatsmedizin Berlin, corporate member of Freie Universitat Berlin, Humboldt-Universitat zu Berlin, and Berlin Institute of Health (BIH), Berlin, Germany Eli Lilly and Company Indianapolis Indiana USA State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of Ceramics Chinese Academy of Sciences 1295 Dingxi Road Shanghai 200050 P. R. China; Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of Sciences 19A Yuquan Road Beijing 100049 P. R. China Department of Burns, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China. Department of Anesthesiology Zhongnan Hospital of Wuhan University Wuhan Hubei Province China; Department of Anesthesiology Peking University Third Hospital Beijing China Center for Excellence in Superconducting Electronics, State Key Laboratory of Functional Material for Informatics, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, Shanghai 200050, China Department of Physical Education, Shanghai Jiao Tong University, Shanghai, China. Division of Laboratory Safety and Services Northwest A&F University Yangling Shaanxi 712100 China State Key Laboratory of Tribology, Tsinghua University, Beijing 100084, P.R. China The University of Kansas Medical Center, KS City, KS; Department of Orthopedics, the First Affiliated Hospital of Fujian Medical University, Fuzhou Fujian, 350004, P.R.China. Department of Otorhinolaryngology Chinese PLA General Hospital Beijing Vital Statistical Department, Institute of Health Information, Shanghai Municipal Center for Disease Control and Prevention , Shanghai 200336 , China State Key Laboratory of Vegetation and Environmental Change Institute of Botany Chinese Academy of Sciences Beijing 100093 China; Department of Ecology and Evolutionary Biology University of California Los Angeles California 90095 USA Department of Clinical Pharmacology, School of Pharmacy China Medical University Shenyang Liaoning China Department of Thoracic Surgery, People’s Liberation Army of China General Hospital, Beijing, P. R. China From the International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, China (D.-D.W., L.G., M.-X.G., Y.L., J.Z., L.C., J.-X.F., X.-H.L., H.-F.H.) International Co-operation Laboratory on Signal Transduction, Eastern Hepatobiliary Surgery Institute, Second Military Medical University, Shanghai, China; National Center for Liver Cancer, Shanghai, China Department of Gynecology Oncology, Affiliated Tumor Hospital of Nantong University, Nantong, China The Affiliated Suzhou Hospital of Nanjing Medical University; Suzhou; China International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China College of Information Engineering, Shanghai Maritime University, Shanghai 201306, China; Shanghai Key Laboratory of PMMP, East China Normal University, Shanghai 200241, China Department of Ophthalmology, Shanghai Tenth People’s Hospital, Tongji University, School of Medicine, Shanghai, China Department of Pharmacy, Shenzhen Hospital of Guangzhou University of Chinese Medicine, Shenzhen 518032, Guangdong, China Ocean College, Zhoushan Campus, Zhejiang University, Zhoushan 316021, People’s Republic of China Institute of Pomology, Jilin Academy of Agricultural Sciences, Changchun, Jilin Province, China Department of Electrical and Electronic Engineering, Southern University of Science and Technology, Shenzhen 518055, China; Shenzhen Engineering Research Center for High Resolution Light Field Display and Technology, Southern University of Science and Technology, Shenzhen 518055, China Zhejiang Hisun Pharmaceutical Co, Ltd, Taizhou, 318099 Zhejiang, China Ministry of Education Key Laboratory of Analytical Science of Food Safety and Biology; Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety; College of Chemistry; Fuzhou University; Fuzhou Center for Mitochondrial Biology and Medicine, The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology and Frontier Institute of Science and Technology, Xi'an Jiaotong University Xi'an China Pancreas Center, Department of General Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China; Pancreas Institute of Nanjing Medical University, Nanjing 210029, China School of Life Sciences, Qufu Normal University, Qufu, Shandong, China College of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, P. R. China Howard Hughes Medical Institute and the Departments of Pathology and of Developmental Biology, and State Key Laboratory of Materials-Oriented Chemical Engineering, College of Chemical Engineering, Nanjing Tech University, Nanjing 210009, China First Clinical Medical School, Traditional Chinese Medicine, Jinan, Shandong, China (mainland) Department of Hematology, Liaocheng People's Hospital, Liaocheng, China. Vital Statistical Department, Institute of Health Information, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China Surgical Department I (Urology Department), Longhua Hospital Shanghai University of Traditional Chinese Medicine, Xuhui 200032, Shanghai, China Department of Anesthesiology Zhongnan Hospital of Wuhan University Wuhan China Department of Physics and Astronomy and Wright Center for Photovoltaics Innovation and Commercialization, The University of Toledo, Toledo, OH 43606, USA. NanoOpto Corp., 1600 Cottontail Lane, Somerset, NJ 08873, USA. Department of Physiology Faculty of Medicine Qingdao University Qingdao 266071 Shandong China Institute of Hematology; Department of Pharmacology, School of Pharmacy Bengbu Medical College Bengbu China Department of Pharmacy, Shenzhen Hospital of Guangzhou University of Chinese Medicine, Shenzhen, Guangdong 518000, P.R. China Department of Burns, Wound Repair and Reconstruction, First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, P.R. China Department of Physical Therapy, International University of Health and Welfare: 2600-1 Kitakanemaru, Otawara city, Tochigi 324-8501, Japan Institute of Information Engineering, Tianjin University of Commerce, Tianjin 300134, China Molecular Neuroscience and Vascular Biology Laboratory, Department of Neurosurgery, Laboratory for Synthetic Chemistry and Chemical Biology Limited, Hong Kong SAR 999077, China Neurovascular Center, Naval Medical University Changhai Hospital, Shanghai, China The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine of Ministry of Education; School and Hospital of Stomatology; Wuhan University; Wuhan 430079; P. R. China Department of Endocrinology and Metabolism Shanghai Jiao Tong University Affiliated Sixth People's Hospital Shanghai China Department of Obstetrics and Gynecology, Navy Clinical College, Anhui Medical University, Hefei 230032; Department of Obstetrics and Gynecology, Sixth Medical Center of PLA General Hospital, Beijing 100048, China. *Corresponding author, E-mail: 3313400243@qq.com. Department of Interventional Vascular Surgery, Suzhou Municipal Hospital, Suzhou Hospital Affiliated to Nanjing Medical University Suzhou, Jiangsu Province, PR China. Center for Molecular Imaging and Nuclear Medicine State Key Laboratory of Radiation Medicine and Protection School for Radiological and Interdisciplinary Sciences (RAD‐X) Soochow University Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions Suzhou 215123 China School of Materials Science Engineering Smart Sensing Interdisciplinary Science Center Key Laboratory of Advanced Energy Materials Chemistry (Ministry of Education) Nankai University Tianjin 300350 China Jiangsu Key Laboratory of Big Data Security and Intelligent Processing, Nanjing University of Posts and Telecommunications, Nanjing, China. Department of Radiology and BRIC, University of North Carolina, Chapel Hill, USA. College of Information Engineering Shanghai Maritime University Shanghai China Department of Molecular Oncology Eastern Hepatobiliary Surgery Hospital & National Center of Liver Cancer Second Military Medical University Shanghai China Center for Reproductive Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China;; Henan Key Laboratory of Reproduction and Genetics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China; College of Animal Science and Technology Sichuan Agricultural University Chengdu China; Key Laboratory of Livestock and Poultry Multi‐omics, Ministry of Agriculture and Rural Affairs, Institute of Animal Genetics and Breeding Sichuan Agricultural University Chengdu China Key Laboratory of Livestock and Poultry Multi-Omics, College of Animal and Technology, Sichuan Agricultural University, Chengdu 611130, China; Farm Animal Genetic Resource Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, China Department of Neurological Surgery, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, People’s Republic of China Division of Pulmonary Diseases, State Key Laboratory of Biotherapy of China, and Department of Respiratory and Critical Care Medicine, West China Hospital of Sichuan University, Chengdu, Sichuan, China Department of Ophthalmology, The First Hospital of China Medical University; Liaoning Diabetic Eye Center, Shenyang, Liaoning Province, China. Hubei Key Laboratory of Smart Internet Technology, School of Electronic Information and Communications, Huazhong University of Science and Technology, Wuhan 430074, China; National Engineering Research Center of Fire and Emergency Rescue, Wuhan 430074, China Yantai Institute of Costal Zone Research Chinese Academy of Sciences Yantai China Key Laboratory of Hubei Province for Occupational Hazard Identification and Control, School of Public Health, Wuhan University of Science and Technology, Wuhan, Hubei 430065, China. Department of Acupuncture, Ningbo Municipal Hospital of TCM, Affiliated Hospital of Zhejiang Chinese Medical University, Ningbo, China Department of Nephrology and Medical Intensive Care (L.C., G. Moll, R.C.), Charité Universitätsmedizin Berlin, Germany.; Department of Nephrology, The Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai, China (L.C.). International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200030, China; Shanghai Key Laboratory of Embryo Original Disease, Shanghai 200040, China; Shanghai Municipal Key Clinical Specialty, Shanghai 200030, China School of Food Science and Technology, National Engineering Research Center of Seafood, Dalian Polytechnic University, Dalian, P. R. China *Divisions of Experimental Hematology and; Molecular and Developmental Biology Graduate Program, University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229 Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, China; Department of Biological Sciences, Texas Tech University, Lubbock, TX, USA Department of Clinical Laboratory, The Navy General Hospital, No. 6 Fucheng Road, Beijing 100037, China Department of Abdominal Medical Oncology Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital) Institute of Cancer and Basic Medicine (IBMC) Chinese Academy of Sciences Hangzhou Zhejiang China Center for Nanoscale Science and Technology, National Institute of Standards and Technology (NIST), Gaithersburg, Maryland 20899, United States Center for Ecological and Environmental Sciences, Northwestern Polytechnical University, Xi'an 710072, China College of Materials Science and Engineering, Changsha University of Science and Technology, Changsha 410114, China Department of Dermatology, State Key Laboratory of Biotherapy and Cancer Center, National Clinical Research Center for Geriatrics, West China Hospital, and West China School of Pharmacy, Sichuan University, Chengdu 610041, P.R. China Brain Center Shenzhen Key Laboratory of Neurosurgery Shenzhen Second People's Hospital, Graduate School of Guangzhou Medical University Sungang West Road Shenzhen 518035 Guangdong Province China; Health Science Center Shenzhen University Shenzhen Guangdong Province China Shanghai United Imaging Intelligence Co. , Ltd., Shanghai 201807 , China Department of Entomology, Nanjing Agricultural University, Nanjing 210095, China Tribology Research Institute, Key Laboratory of Advanced Technologies of Materials, Ministry of Education of China, Southwest Jiaotong University, Chengdu 610031, People’s Republic of China; Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China Laboratory of Clinical Pharmacy and Adverse Drug Reaction Chengdu Sichuan, 610041 China; Department of Pharmacy, State Key Laboratory of Biotherapy West China School of Pharmacy, Sichuan University Chengdu Sichuan, 610041 China Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China Department of Neurosurgery The Second Affiliated Hospital of Harbin Medical University Harbin 150086 China Department of Chemistry, Yale University, New Haven, Connecticut06520, United States School of Information Science and Engineering, Shandong University, Qingdao 266200, China Tianjin University of Commerce Department of Orthopedics, Tongji Hospital, School of Medicine, Tongji University, 389 Xincun Road, Shanghai 200065, P. R. China Department of Otorhinolaryngology Head and Neck Surgery, General Hospital of Chinese People's Liberation Army, Beijing 100853, China. chenlei301@hotmail.com National Research Center for High-Efficiency Grinding, College of Mechanical and Vehicle Engineering, Hunan University, Changsha 410082, China Neuromuscular Center at The Research Institute at Nationwide Children's Hospital Columbus Ohio; Department of Pediatrics and Center for Gene Therapy The Research Institute at Nationwide Children's Hospital 700 Children's Drive Columbus Ohio 43205 Science for Life Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, SE-751 85 Uppsala, Sweden; Rarity Bioscience AB, SE-752 37 Uppsala, Sweden Department of Neuroscience, Mount Sinai School of Medicine, New York, New York, USA School of Life Science and Technology, Key Laboratory of Developmental Genes and Human Disease, Southeast University, Nanjing210096, China Department of Hematology, Affiliated Hospital of Weifang Medical University, P.R. China Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education College of Life Science Jilin University Changchun Jilin Province China College of Information Engineering; Shanghai Maritime University; Shanghai 201306; People's Republic of China Department of Cardiothoracic Surgery Zhuhai People's Hospital (Zhuhai hospital affiliated with Jinan University) Zhuhai City Guangdong Province China 1International Co-operation Laboratory on Signal Transduction, Eastern Hepatobiliary Surgery Institute, Second Military Medical University, Shanghai, China.; 4National Center for Liver Cancer, Shanghai, China. Department of Otorhinolaryngology Head and Neck Surgery, General Hospital of Chinese Peoples Liberation Army, Beijing. chenlei301@hotmail.com Department of Cardiology Shanghai East Hospital Tongji University School of Medicine Shanghai China; Key Laboratory of Arrhythmias of the Ministry of Education of China Shanghai East Hospital Tongji University School of Medicine Shanghai China International Cooperation Laboratory on Signal Transduction Ministry of Education Key Laboratory on Signaling Regulation and Targeting Therapy of Liver Cancer Shanghai Key Laboratory of Hepato‐biliary Tumor Biology Eastern Hepatobiliary Surgery Hospital Second Military Medical University Shanghai China West China School of Pharmacy and State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, People’s Republic of China Nanoopto Corporation, 1600 Cottontail Lane, Somerset, New Jersey 08873 State Key Laboratory of Tribology, Tsinghua University, Beijing 100084, P. R. China Division of Pulmonary Diseases State Key Laboratory of Biotherapy of China West China Hospital West China School of Medicine Sichuan University Chengdu Sichuan China; Department of Respiratory Medicine West China Hospital West China School of Medicine Sichuan University Chengdu Sichuan China Shenzhen University School of Medicine, Shenzhen, Guangdong, China; Department of Neurosurgery, Shenzhen Second People’s Hospital, the First Affiliated Hospital of Shenzhen University, Shenzhen, Guangdong, China State Key Laboratory for Agro‐biotechnology China Agricultural University Beijing 100083 People's Republic of China Department of Radiation Oncology Sun Yat‐sen University Cancer Center State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Guangzhou China; Department of Experimental Radiation Oncology The University of Texas MD Anderson Cancer Center Houston TX USA College of Life Science, Qufu Normal University, Qufu, China Department of Food Science and Human Nutrition and Department of Entomology, University of Illinois, Urbana, Illinois 61801, and Rush Medical Center, Chicago, Illinois School of Basic Medicine, Gannan Medical University, Ganzhou, China Department of Physiology and Pathophysiology, School of Basic Medicine, Qingdao University, 308 Ningxia Road, Qingdao 266071, China State Key Laboratory of Bioreactor Engineering East China University of Science and Technology Shanghai China Department of Respiratory and Critical Care Medicine, West China Hospital of Sichuan University, and Division of Pulmonary Diseases, State Key Laboratory of Biotherapy of China, Chengdu 610041, China Division of Geriatric Respiratory, the First Affiliated Hospital of Nanjing Medical University, People’s Republic of China Center for Clinical Research and Translational Medicine Yangpu Hospital, Tongji University School of Medicine Shanghai P. R. China; Department of Hepatic Surgery Eastern Hepatobiliary Surgery Hospital, Navy Military Medical University Shanghai P. R. China Key Laboratory of Agricultural Microbiology, College of Plant Protection, Shandong Agricultural University, Tai’an, China; State Key Laboratory of Crop Biology, Shandong Agricultural University, Tai’an, China School of Pharmaceutical Science and Technology Tianjin University Tianjin China Reproductive Medical Center, First Affiliated Hospital of Zhengzhou University , Zhengzhou, China Jinan University Eli Lilly & Company, Indianapolis, IN, USA South China Botanical Garden Chinese Academy of Sciences Guangzhou 510650 China Forage Biotechnology Group, Plant Biology Division, and Agriculture Division, Samuel Roberts Noble Foundation, 2510 Sam Noble Parkway, Ardmore, Oklahoma 73401 The People`s Hospital of Pudong New Area, 490 South Chuanhuan Road, Chuansha New Town, Shanghai 201299, China VA Palo Alto Healthcare System, Palo Alto, CA 94304, USA.; Program in Epithelial Biology, 269 Campus Drive, Stanford University School of Medicine, Stanford, CA 94305, USA.; Department of Biochemistry and Molecular Biology, Oregon Health and Science University, Portland, OR 97201, USA Department of Cardiology, Institute of Cardiovascular Research, Affiliated Hospital of Xuzhou Medical University, Xuzhou, China. From the Departments of Radiation Oncology (Y.Z., L.C., Y.-P.C., W.-H.H., W.-F.L., L.-L.T., Y.-P.M., G.-Q.Z., R.S., X.L., R.G., F.H., J.-W.L., X.-J.D., C.X., N.L., Y.-Q.L., F.-Y.X., Ying Sun, J.M.), Medical Oncology (Y.-H.L.), and Nasopharyngeal Carcinoma (H.-Y.M.) and the Clinical Trials Center (Y.G.), Sun Yat-sen University Cancer Center, the State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma... Laboratory of Synthetic Microbiology, School of Chemical Engineering & Technology, Tianjin University, Tianjin 300072, P.R. China; Key Laboratory of Systems Bioengineering, Ministry of Education of China, Tianjin 300072, P.R. China; Collaborative Innovation Center of Chemical Science & Engineering, Tianjin, P.R. China School of Food Science and Engineering, Wuhan Polytechnic University, Wuhan 430023, China; Key Laboratory for Deep Processing of Major Grain and Oil, Ministry of Education, Hubei Key Laboratory for Processing and Transformation of Agricultural Products, Wuhan Polytechnic University, Wuhan 430023, China VCU Philips Institute of Oral and Craniofacial Molecular Biology, Virginia Commonwealth University, Richmond, VA 23298-0566, USA Department of Anesthesia The First Affiliated Hospital Jinan University Guangzhou P.R. China Department of Vascular Surgery, Fuxing Hospital Affiliated to Capital Medical University, Xicheng District, Beijing, China College of Food Science, Fujian Agriculture and Forestry University, Fuzhou, Fujian, China; Department of Radiology, Peking University People's Hospital School of Electrical and Information Engineering, Wuhan Institute of Technology, Wuhan 430205, China Department of Radiology, Union Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan China; Hubei Key Laboratory of Molecular Imaging Wuhan China Center for Mitochondrial Biology and Medicine and Center for Translational Medicine The Key Laboratory of Biomedical Information Engineering of Ministry of Education School of Life Science and Technology and Frontier Institute of Science and Technology Xi'an Jiaotong University Xi'an China Department of Physiology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. Department of Physiology, Nanjing Medical University , 101 Longmian Avenue, Jiangning District, Nanjing 211166 , China Fert Beijing Institute, MIIT Key Laboratory of Spintronics, School of Integrated Circuit Science and Engineering, Beihang University, Beijing 100191, China 3Division of Hematology and Oncology, Department of Internal Medicine; Department of Orthodontics, Shanghai Engineering Research Center of Tooth Restoration and Regeneration, School & Hospital of Stomatology, Tongji University, Shanghai, China. Department of Pharmaceutical Engineering; School of Chemistry and Chemical Engineering; Jiangsu Province Hi-Tech Key Laboratory for Biomedical Research; Southeast University; Nanjing 211189 Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, People’s Republic of China Hefei National Laboratory for Physical Sciences at Microscale and Department of Modern Physics, University of Science and Technology of China, Hefei, Anhui 230026, China 1Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, P.R. China. BGI-Shenzhen, Shenzhen, China. College of Food Science and Technology, Guangdong Ocean University, Zhanjiang, China CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety Institute of High Energy Physics Chinese Academy of Sciences Beijing 100049 P. R. China College of Chemistry and Chemical Engineering, Anhui University and Key Laboratory of Functional Inorganic Materials Chemistry of Anhui Province, Anhui Province Key Laboratory of Chemistry for Inorganic/Organic Hybrid Functionalized Materials, Key Laboratory of Structure and Functional Regulation of Hybrid Materials, Anhui University, Ministry of Education, Hefei 230601, P. R. China Department of Chemistry; Fudan University; Shanghai 200433; P. R. China Key Laboratory of Advanced Structural-Functional Integration Materials & Green Manufacturing Technology, Harbin Institute of Technology, Harbin 150001, China Surgical Department I (Urology Department), Longhua Hospital Shanghai University of Traditional Chinese Medicine, Xuhui, Shanghai 200032, China The Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan 430022, China. Hubei Province Key Laboratory of Molecular Imaging Wuhan 430022, China. The Department of Interventional Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan 430022, China. Department of Interventional Oncology, Suzhou Municipal Hospital, Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, People's Republic of China. State Key Laboratory for Medical Genomics, Institute of Health Science, Shanghai Institute for Biological Sciences and Graduate School, Chinese Academy of Sciences, and Shanghai Institute of Hematology, Rui-Jin Hospital, Shanghai 200025, People's Republic of China; Department of Plant Pathology; College of Agriculture and Biotechnology, China Agricultural University; Beijing P. R. China; College of Forestry; Beijing Forestry University; Beijing P. R. China Novartis Pharmaceuticals Corporation East Hanover, NJUSA School of Information Engineering, Tianjin University of Commerce, Beichen, Tianjin 300134 Novartis Pharmaceuticals Corporation, East Hanover, NJ, USA State Key Laboratory for Manufacturing Systems Engineering 1 , Xi'an, Shaanxi 710049, People's Republic of China; Xi'an Jiaotong University 2 School of Mechanical Engineering, , Xi'an, Shaanxi 710049, People's Republic of China Dialysis Department of Nephrology Hospital The First Affiliated Hospital of Xi’an Jiaotong University Xi’an Shaanxi China College of Animal Science and Technology, Northwest A&F University Yangling Shaanxi China Department of Otolaryngology Head and Neck Surgery the Second Hospital of Tianjin Medical University Tianjin China Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Institute of Functional Nano and Soft Materials (FUNSOM), SWC for Synchrotron Radiation Research, and Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou 215123, PR China School of Material Science & Engineering, National Experimental Demonstration Center for Materials Science and Engineering, Jiangsu Province Cultivation base for State Key Laboratory of Photovoltaic Science and Technology, Changzhou University, Changzhou, Jiangsu 213164, China The Army Engineering University of PLA, Nanjing, China State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China; Department of Physics, Shanghai University, Shanghai 200444, China School of Chemical Engineering, Nanjing University of Science and Technology, Nanjing 210094, China Department of Critical Care Nephrology and Blood Purification the First Affiliated Hospital of Xi'an Jiaotong University Shannxi 710061 China Key Laboratory of Advanced Energy Materials Chemistry (Ministry of Education) School of Materials Science and Engineering Smart Sensing Interdisciplinary Science Center Nankai University Tianjin 300350 China Jiangsu Key Laboratory of Xenotransplantation, Nanjing Medical University, Nanjing 211166, China Department of Otorhinolaryngology Head Neck Surgery, People Liberation Army General Hospital, Beijing 100853, China. Email: chen301@aliyun.com. National Center for Liver Cancer Shanghai 200441 China; The International Cooperation Laboratory on Signal Transduction Eastern Hepatobiliary Surgery Hospital Second Military Medical University Shanghai 200438 China; Fudan University Shanghai Cancer Center Department of Oncology Shanghai Medical College Fudan University Shanghai 200032 China Department of Otolaryngology–Head and Neck Surgery Chinese PLA General Hospital Beijing China Eli Lilly and Company, Indianapolis, IN, USA College of Chemical Engineering Hebei United University Tangshan Hebei 063009 China Department of Critical Care Nephrology and Blood Purification, The First Affiliated Hospital of Xi'an Jiaotong University , Xi'an , China Department of Respiratory and Critical Care Medicine, Ningbo, Zhejiang, China. Department of Endocrinology and Metabolism, Sir Run Run Shaw Hospital Affiliated with School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China (mainland) School of Materials Science and Engineering, Jilin Jianzhu University, Changchun 130118, China Section of Pediatric EmergencyMedicine, Department of Pediatrics Department of Thoracic Surgery, Chinese PLA General Hospital, Beijing, People’s Republic of China Cancer Hospital of Shantou University Medical College, Shantou, Guangdong Province, People’s Republic of China State Key Laboratory of Animal Biotech Breeding, National Engineering Laboratory for Animal Breeding, Key Laboratory of Animal Genetics, Breeding and Reproduction of the Ministry of Agriculture and Rural Affairs, College of Animal Science and Technology China Agricultural University Beijing China Department of Ophthalmology, The First Affiliated Hospital of China Medical University, Shenyang, People’s Republic of China From the Department of Medicine (G.-R.L., H.-Y.S., X.-L. Du, X.-L. Deng, H.-F.T., C.-P.L.) and Department of Physiology (G.-R.L.), Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China; Shanghai Institute of Materia Medica (H.-B.W., G.-W.Q.), Chinese Academy of Science, Shanghai, China; Department of Pharmacology (M.-W.J., Q.T., X.-H.Z., J.-B.C., L.C., X.-H.X.), Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Cardiothoracic... Department of Thoracic Surgery Renmin Hospital of Wuhan University Wuhan Hubei China Department of Gynaecology and Obstetrics, PLA Navy General Hospital, Beijing 100037, China Department of Pharmacy West China Hospital of Sichuan University and Collaborative Innovation Center of Biotherapy Chengdu Sichuan China; Laboratory of Clinical Pharmacy and Adverse Drug Reaction West China Hospital of Sichuan University and Collaborative Innovation Center of Biotherapy Chengdu Sichuan China Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangzhou, People's Republic of China State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry, Jilin University, Changchun 130012, People's Republic of China, and State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Institute of Physics and Mathematics, The Chinese Academy of Sciences, Wuhan 430071, People's Republic of China Navy Clinical College, Anhui Medical University, Hefei 230032; Department of Obstetrics and Gynecology, Navy General Hospital of PLA, Beijing 100048, China. *Corresponding author, E-mail: 3313400243@qq.com. School of Life Sciences, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China; CUHK Shenzhen Research Institute, Shenzhen, China Philips Institute, Virginia Commonwealth University, Richmond, VA, USA. Department of Pathology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China Department of Molecular Oncology, National Center for Liver Cancer, Eastern Hepatobiliary Surgery Hospital, Navy Military Medical University, Shanghai 200438, P.R. China Institute for Superconducting and Electronic Materials; Australian Institute for Innovative Materials; University of Wollongong; North Wollongong; Australia Ultrasonography Department, Hangzhou Women's Hospital, Hangzhou, Zhejiang, China. Institute of Translational Medicine, Department of Pharmacy, Shenyang Medical College, Shenyang 110034, China CAS Engineering Laboratory for Nanozyme Key Laboratory of Biomacromolecules Institute of Biophysics Chinese Academy of Sciences Chaoyang Beijing 100101 China Department of Thoracic Surgery, Renmin Hospital of Wuhan University, Wuhan, China Department of Materials, College of Engineering, Zhejiang A & F University, 666 Wusu Street, Linan District, Hangzhou 311300, China Laboratory of Synthetic Microbiology; School of Chemical Engineering & Technology; Tianjin University; Tianjin 300072, P.R. China; Key Laboratory of Systems Bioengineering Section of Pediatric Emergency Medicine, Yale University School of Medicine, New Haven, Connecticut Department of Physics and Astronomy and Wright Center for Photovoltaics Innovation and Commercialization The University of Toledo 2801 W. Bancroft Street Toledo OH 43606 USA Section of Pediatric Emergency Medicine, Department of Pediatrics, Yale School of Medicine, New Haven, Connecticut Department of Epidemiology Second Military Medical University Shanghai China Key Laboratory of Optoelectronic Information and Sensing Technologies of Guangdong Higher Education Institutes, Guangdong Provincial Key Laboratory of Optical Fiber Sensing and Communications, Jinan University, Guangzhou 510632, China Department of Gynaecology and Obstetrics, Tangdu Hospital, Fourth Military Medical University, Xi'an, China. Key Laboratory of Livestock and Poultry Multi-omics, Ministry of Agriculture and Rural Affairs, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, China College of Mechanical and Vehicle Engineering Hunan University Changsha 410082 P. R. China; Greater Bay Area Institute for Innovation Hunan University Guangzhou 511300 P. R. China Department of Physiology, Spinal Cord and Brain Injury Research Center University of Kentucky Lexington Kentucky USA Department of Cardiovascular Surgery, Beijing Aortic Disease Center, Beijing Anzhen Hospital, Capital Medical University, Beijing, China; Beijing Institute of Heart Lung and Blood Vessel Diseases, Beijing, China Department of Gastroenterology, Clinical Medical College of Yangzhou University, Northern Jiangsu People’s Hospital, Yangzhou, P. R. China Novartis Pharmaceuticals Corporation, East Hanover, NJ 07936-1080, USA Eternity Bioscience Inc., 6 Cedarbrook Drive, Cranbury, New Jersey 08512, United States School of Food Science and Technology, National Engineering Research Center of Seafood, Dalian Polytechnic University, Dalian 116034, China Department of Endocrinology and Metabolism, Sir Run Run Shaw Hospital Affiliated with the School of Medicine, Zhejiang University, Hangzhou, China Department of Pharmacy, Shenzhen Hospital of Guangzhou University of Chinese Medicine, Shenzhen, Guangdong 518034, P.R. China College of Physics Science Technology, Yangzhou University, Yangzhou 225002, China. chenlei@yzu.edu.cn Department of Materials Science and Engineering; Xi’an University of Technology; Xi’an 710048; P. R. China State Key Laboratory of Functions and Applications of Medicinal Plants, Engineering Research Center for the Development and Application of Ethnic Medicine and TCM (Ministry of Education), Guizhou Provincial Key Laboratory of Pharmaceutics, School of Pharmacy, School of Basic Medical Science, Guizhou Medical University, Guiyang 550004, China Institute of Food and Nutraceutical Science, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China; School of Life Sciences, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China Department of Radiology, Peking University People’s Hospital, Beijing, China Catalytic Hydrogenation Research Center; State Key Laboratory Breeding Base of Green Chemistry-Synthesis Technology; Key Laboratory of Green Pesticides and Cleaner Production Technology of Zhejiang Province; Zhejiang University of Technology; Hangzhou 310014 Department of Chemistry, Rutgers University−Newark, 72 Warren Street, Newark, New Jersey 07102, United States Department of Anatomy, Histology, and Embryology, K. K. Leung Brain Research Centre, Fourth Military Medical University, Xi'an, China. Northeast Petroleum University Qinhuangdao, Qinhuangdao, Hebei 066004, China The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan, China Key Laboratory of Smart Agriculture and Forestry, College of Computer and Information Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. Department of Pathology and Laboratory Medicine The University of Texas Health Science Center at Houston Houston Texas USA; Department of Laboratory Medicine The University of Texas MD Anderson Cancer Center at Houston Houston Texas USA Department of Urology, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230601, P.R. China From the Departments of Neurology (W.X., J.M., J.G., L.L., H.G., Y.Z., M.L., S.S., H.Z., L.C., L.H., D.Z.), Pulmonary & Critical Care Medicine (D.L., G.W., W.L.), and Medical Affairs (N.L.), West China Hospital of Sichuan University, Chengdu; Department of Gastrointestinal Surgery (J. Luo), Renmin Hospital of Wuhan University; Department of Neurology (J. Liu, D.Y., S.C.), Chongqing Three Gorges Central Hospital, Chongqing; NIHR University College London Hospitals Biomedical Research Centre (J.W... Tsinghua University Graduate School at Shenzhen, Shenzhen 518101, China Department of Ophthalmology, The First Affiliated Hospital of China Medical University, Shenyang 110001, China; Key Laboratory of Endocrine Diseases in Liaoning Province, The First Hospital of China Medical University, Shenyang 110001, China Department of Pathology and Laboratory Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA Lei.Chen.1@uth.tmc.edu. Department of Radiation Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, China Guangdong Provincial Key Laboratory of Nanophotonic Functional Materials and Devices; School of Information and Optoelectronic Science and Engineering; South China Normal University; Guangzhou 510006, P. R. China Shenzhen Hospital of Guangzhou University of Chinese Medicine, Shenzhen, 518034 Guangdong, China Department of Gastroenterology Beijing Friendship Hospital Capital Medical University National Clinical Research Center for Digestive Disease Beijing Digestive Disease Center Beijing Key Laboratory for Precancerous Lesion of Digestive Disease Beijing P. R. China Center for Nanoscale Science & Technology, National Institute of Standards & Technology, 100 Bureau Drive, Stop 6201, Gaithersburg, MD 20899-6201, USA. Department of Cardiovascular Surgery, Shandong Provincial Hospital affiliated to Shandong First Medical University and Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong Province, People’s Republic of China College of Environmental Science and Engineering, and Key Laboratory of Marine Environment and Ecology, Ministry of Education Ocean University of China Qingdao 266100 China Department of Cardiovascular Medicine State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100193, China; Guangdong Laboratory for Lingnan Modern Agriculture (Shenzhen Branch), Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen 518120, China Division of Medicinal and Natural Products Chemistry, Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, The University of Iowa, Iowa City, Iowa 52242, United States Center for Molecular Imaging and Nuclear Medicine School for Radiological and Interdisciplinary Sciences (RAD‐X) Soochow University Suzhou 215123 China; Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions Suzhou 215123 China Section of Pediatric Emergency Medicine, Department of Pediatrics Yale-New Haven Children's Hospital, New Haven, Connecticut; and Institute of Nutrition & Health, School of Public Health, Qingdao University, 38 Dengzhou Road, 266021 Qingdao, China Department of Pediatric Surgery Cangzhou Central Hospital Cangzhou China School of Public Health, Qingdao University, Qingdao 266000, China; Institute of Nutrition & Health, Qingdao University, Qingdao 266000, China Institute of Sericulture and Tea, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, China Guangdong Metabolic Diseases Research Center of Integrated Chinese and Western Medicine Guangdong Pharmaceutical University Guangzhou People's Republic of China Tribology Research Institute, State Key Laboratory of Traction Power, Southwest Jiaotong University, Chengdu 610031, China Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, China; Key Laboratory of Livestock and Poultry Multi-Omics, Ministry of Agriculture and Rural Affairs, College of Animal and Technology, Sichuan Agricultural University, Chengdu 611130, China Beijing Xiaoying Technology Co, Ltd , Beijing , China School of Chemistry & Chemical Engineering; Shandong University of Technology; Zibo 255049; P. R. China College of Engineering, Shenyang Agricultural University, Shenyang, 110866, P. R. China Traditional Chinese Medicine Hospital of Guangdong Province, Guangzhou, China. Guangdong Provincial Research Center for Environment Pollution Control and Remediation Materials, School of Environment, Jinan University, Guangzhou 510632, China Department of Pathology; Xinhua Hospital; Shanghai Jiaotong University School of Medicine; Shanghai China Department of Physiology, School of Basic Medical Sciences, Anhui Medical University, Hefei, Anhui 230022, P.R. China Department of Urology Shanghai General Hospital Shanghai Jiao Tong University School of Medicine Shanghai China 1Department of Genetics, Human Genetics Institute of New Jersey, Rutgers, The State University of New Jersey, Piscataway, New Jersey. College of Electronics and Information Engineering Shanghai University of Electric Power Shanghai 200090 China Department of Material Science and Engineering, National University of Singapore, Singapore 117574 Key Laboratory of Carbohydrate Chemistry and Biotechnology, School of Biotechnology and ‡School of Food science and Technology, Jiangnan University, Wuxi 214122, China; Beijing Engineering and Technology Research Center of Food Additives and ⊥Beijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Technology and Business University, Beijing 100048, China State Key Laboratory of Functions and Applications of Medicinal, Plants Engineering Research Center for the Development and Application of Ethnic Medicine and TCM (Ministry of Education), Guizhou Provincial Key Laboratory of Pharmaceutics, School of Pharmacy, School of Basic Medical Science, Guizhou Medical University, Guiyang 550004, China Center for Gene Therapy The Research Institute at Nationwide Children’s Hospital Columbus Ohio Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou, China; Nanfang Neurology Research Institution, Nanfang Hospital, Southern Medical University, Guangzhou, China Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. School of Life Sciences, Sun Yat-sen University , Guangzhou , P.R. China Department of Pathology The University of Texas Health Science Center at Houston Houston TX USA School of Chemistry and Chemical Engineering, Nanjing University of Science and Technology, Nanjing 210094, China School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin Hong Kong, China. Key Laboratory of Science and Technology on Wear and Protection of Materials, Chinese Academy of Science, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, P.R. China; Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, Beijing 100049, PR China Key Laboratory of Bio-resources and Eco-environment, Ministry of Education, College of Life Science, Sichuan University, Chengdu, China Division of Pulmonary Diseases, State Key Laboratory of Biotherapy of China, and Department of Respiratory and Critical Care Medicine, West China Hospital of Sichuan University, Chengdu, Sichuan State Key Laboratory of Oncology in South China, Guangzhou, Guangdong, 510060, P. R. China. drleichen@gmail.com Institute of Surgery Research, Daping Hospital of the Third Military Medical University, Chongqing 400042. Key Lab of Biomechanics & Tissue Engineering under the State Ministry of Education, Chongqing University, Chongqing 400044. School of Pharmaceutical and Materials Engineering Taizhou University Taizhou 317000 P. R. China Department of Neurosurgery Fudan University Shanghai Cancer Center Shanghai China; Department of Oncology, Shanghai Medical College Fudan University Shanghai China Department of Ultrasound in Medicine, Shanghai Institute of Ultrasound in Medicine, Shanghai Jiao Tong University Affiliated 6th People’s Hospital, Shanghai, People's Republic of China Department of Orthopaedic, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian Province, China Division of Environmental Health, University of Cincinnati, Cincinnati, Ohio Philips Institute for Oral Health Research, Virginia Commonwealth University, Richmond, Virginia, USA Institute of Agro‐products Processing Anhui Academy of Agricultural Sciences Hefei 230031 China Tribology Research Institute, Key Laboratory of Advanced Technologies of Materials (Ministry of Education), Southwest Jiaotong University , Chengdu 610031, China School of Marine Science and Environmental Engineering Dalian Ocean University Dalian 116023 China; School of Life Sciences Liaoning Normal University Dalian 116029 China Department of Plastic Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania Department of Cardiothoracic Surgery, the Second Affiliated Hospital of Soochow University, Suzhou 215002, China Department of Anesthesiology Liyang People's Hospital Liyang Jiangsu China Department of Obstetrics and Gynecology, Sixth Medical Center of the People’s Liberation Army (PLA) General Hospital, Beijing, China (mainland) Center for Mitochondrial Biology and Medicine; The Key Laboratory of Biomedical Information Engineering of Ministry of Education; School of Life Science and Technology and Frontier Institute of Science and Technology; Xi’an Jiaotong University; Xi’an 710049 Key Laboratory of Advanced Braided Composites, Ministry of Education, School of Textiles, Tianjin Polytechnic University, Tianjin 300387, P. R. China *Key Laboratory of Molecular and Developmental Biology, Institute of Genetics and Developmental Biology, School of Food Science and Engineering, Wuhan Polytechnic University, Wuhan 430023, China; Key Laboratory of Grain and Oil Processing, Ministry of Education, Wuhan 430023, China Department of Critical Care Medicine, The Sixth Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China Institut für Ionenphysik und Angewandte Physik, Universität Innsbruck, Technikerstrasse 25, A-6020 Innsbruck, Austria State Key Laboratory of Biotherapy of China, Division of Pulmonary Diseases, Department of Respiratory Medicine, West China Hospital of Sichuan University, Chengdu, China. Department of Prosthodontics, Peking University School and Hospital of Stomatology, Beijing 100081, China. Sino-American Collaborative Laboratory, State Key Laboratory of Experimental Haematology, Institute of Haematology and Blood Diseases Hospital, and Tissue Engineering Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300020, P.R. China. Shandong Academy of Pharmaceutical Sciences, Key Laboratory of Biopharmaceuticals, Engineering Laboratory of Polysaccharide drugs, National‐Local Joint Engineering Laboratory of Polysaccharide drugs Postdoctoral Scientific Research Workstation Jinan China School of Medicine, Xi’an Peihua University; Department of Pharmacy, Xijing Hospital, Fourth Military Medical University From the Department of Psychiatry, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada (EA-J); the Department of Psychiatry, University Health Network, University of Toronto, Toronto, Ontario, Canada (EA-J, PS); Global Medicines Development, AstraZeneca Canada, Inc., Mississauga, Ontario, Canada (LC); the Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada (PC); the Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada (TB); and... Department of Orthopaedics The First Affiliated Hospital of Wenzhou Medical University Wenzhou 325000 China Department of Neurology, The Second Hospital of Hebei Medical University; Department of Neurology, The first hospital of Shijiazhuang, Shijiazhuang Department of Obstetrics and Gynecology, Navy General Hospital of People Liberation Army, Beijing 100048, China School of Chemistry and Chemical Engineering; Nantong University; Nantong; P. R. China; SEU-FEI Nano-Pico Center Shandong Bausch & Lomb Freda Co., Ltd; Shandong Academy of Pharmaceutical Sciences Digestive Department of Subei People's Hospital, Clinical College of Yangzhou University, Yangzhou 225001, P.R. China Department of Anesthesiology Zhongnan Hospital of Wuhan University Wuhan P.R. China; Center of Brain Science State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics National Center for Magnetic Resonance in Wuhan Key Laboratory of Magnetic Resonance in Biological Systems Wuhan Institute of Physics and Mathematics Innovation Academy for Precision Measurement Science and Technology Chinese Academy of Sciences Wuhan China Center for Microbiota and Immunological Diseases, Shanghai General Hospital, Shanghai Institute of Immunology, School of Medicine Shanghai Jiao Tong University Shanghai P.R. China Department of Physical Education, Shanghai Jiaotong University, Shanghai 200240, P.R. China Department of Orthodontics, School of Stomatology, Shandong Provincial Key Laboratory of Oral Tissue Regeneration Shandong University Jinan Shandong China Department of Oncology, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, P.R. China. Department of Respiratory and Critical Care Medicine, West China Hospital of Sichuan University and Division of Pulmonary Diseases, State Key Laboratory of Biotherapy of China, Chengdu, China China University of Petroleum (East China); Chinese Academy of Sciences Department of Chemistry, Rutgers University−Newark, Newark, New Jersey 07102, United States Department of Emergency Medicine Xiang'an Hospital of Xiamen University Xiamen Fujian China BGI Genomics, BGI-Shenzhen, Shenzhen, China Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China. Beijing Genomics Institute at Shenzhen Shenzhen Guangdong China Zhengzhou University Department of Pathology and the Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305; and Department of Children’s and Adolescent Health Public Health College of Harbin Medical University Harbin China Department of Burns Surgery, First Affiliated Hospital of Sun Yat-sen University Guangzhou, Guangdong, China. 1Medical Sciences, Indiana University School of Medicine, Bloomington, Indiana; Department of Cardiothoracic Surgery, the Second Affiliated Hospital, Soochow University, Suzhou 215004, China. Diagnostic Ultrasound Center Department of Ophthalmology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, China Shandong Provincial Key Laboratory of Animal Resistance Biology College of Life Sciences Shandong Normal University Jinan China International Cooperation Laboratory on Signal Transduction, Eastern Hepatobiliary Surgery Institute Second Military Medical University Shanghai 200438 P. R. China; National Center for Liver Cancer Shanghai 201805 P. R. China Shandong Key Laboratory of Animal Disease Control and Breeding, Institute of Animal Science and Veterinary Medicine, Shandong Academy of Agricultural Sciences, Sangyuan Road No. 8, Jinan 250100, China State Key Laboratory of Coordination Chemistry Collaborative Innovation Center of Advanced Microstructures Jiangsu Key Laboratory of Advanced Organic Materials School of Chemistry and Chemical Engineering Nanjing University Nanjing 210023 P. R. China Key Laboratory of Structure‐Based Drug Design and Discovery Ministry of Education Shenyang Pharmaceutical University 103 Wenhua Road Shenhe District Shenyang 110016 China Department of Surgery, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China Key Laboratory of Carbohydrate Chemistry and Biotechnology, School of Biotechnology, Jiangnan University, Wuxi 214122, Jiangsu, P.R. China Guangdong Laboratory for Lingnan Modern Agriculture, (Shenzhen Branch), Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen 440307, P. R. China; State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection and Shenzhen Agricultural Genome Research Institute, Chinese Academy of Agricultural Sciences, Beijing 100193, P. R. China; School of Bioengineering, Dalian University of Technology, Dalian 116024, P. R. China Department of Infectious Disease Control and Prevention, Pizhou county Center for Disease Control and Prevention, Pizhou, Jiangsu, China University of Science and Technology 2 School of Electronic and Optical Engineering, Nanjing , Nanjing 210094, China School of Animal Science and Technology, Shihezi University, Shihezi, China Administrative Examination and Approval Service Center, People’s Government of Shijiazhuang, Shijiazhuang 050601, China School of Ecology and Environment, Northwestern Polytechnical University, Xi’an, Shaanxi, 710072, China. Department of Joints and Sports Medicine; The First Hospital of Jilin University; Changchun; PR China College of Life and Health Science, Anhui Science and Technology University, Fengyang 233100, China State Key Laboratory of Pollution Control and Resource Reuse, School of Environment, Nanjing University, Nanjing 210023, China Department of Periodontics Stomatological Hospital of Southern Medical University Guangdong Provincial Stomatological Hospital Guangzhou 510280 China Center for Microbiota and Immunological Diseases, Shanghai General Hospital, Shanghai Institute of Immunology, School of Medicine, Shanghai Jiao Tong University, Shanghai, China Ministry of Education Key Laboratory of Analysis and Detection for Food Safety; Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, College of Chemistry; Fuzhou University; Fuzhou Fujian China State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China Department of Othopaedics, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang, China; chenlei689595@qq.com. Department of Pharmacy Institute of Clinical Pharmacy Second Xiangya Hospital Central South University Changsha China The School of Public Health, Medical College of Qingdao University, Qingdao, P.R China Departments of Neurosurgery, Institute of Systems Biology, Shanghai University, Shanghai 200444, People’s Republic of China, Centre for Computational Systems Biology, Fudan University, Shanghai 200433, People’s Republic of China, Shanghai Key Laboratory of Trustworthy Computing, East China Normal University, Shanghai 200062, People’s Republic of China, and Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Shanghai Jiao Tong University School of Medicine, Shanghai 200025,... School of Chemistry and Chemical Engineering, Shandong University of Technology, Zibo 255000, China Department of Pediatric Hematology The Affiliated Hospital of Qingdao University Qingdao China Key Laboratory of Traditional Chinese Medicine Digitalization Quality Evaluation under State Administration of Traditional Chinese Medicine, Guangzhou 510006, China. Research Center for Traditional Chinese Medicine Quality Engineering Technology under Guangdong University, Guangzhou 510006, China. Department of Hepato-Pancreato-Biliary & Gastric Medical Oncology, Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences, Hangzhou, Zhejiang, China School of Municipal & Environmental Engineering, Jilin Jianzhu University, Changchun 130118, China Guangdong Provincial Key Laboratory of Optical Fiber Sensing and Communications, Key Laboratory of Visible Light Communications of Guangzhou, Key Laboratory of Optoelectronic Information and Sensing Technologies of Guangdong Higher Education Institutes, College of Physics & Optoelectronic Engineering, Jinan University, Guangzhou 510632, China Department of Psychosomatics and Psychiatry, ZhongDa Hospital, School of Medicine Southeast University Nanjing China Department of Physics and Astronomy & Wright Center for Photovoltaics Innovation and Commercialization, University of Toledo, Toledo, Ohio 43606, United States Department of Oncology, Lanzhou University Second Hospital, Lanzhou, Gansu, China Department of Ultrasound, Hangzhou Women’s Hospital, Hangzhou, Zhejiang, China Institute of Ensiling and Processing of Grass College of Animal Science and Technology Nanjing Agricultural University Nanjing Department of Respiratory and Critical Care Medicine, West China Hospital of Sichuan University and Division of Pulmonary Diseases, State Key Laboratory of Biotherapy of China , Chengdu , Sichuan Province , China Department of Orthopedics, The First Affiliated Hospital, Wenzhou Medical College, Zhejiang, China. Department of Respiratory and Intensive Care Medicine, Yichang No.3 People's Hospital, Yichang 443003, Hubei, China. Corresponding author: Guo Pingqing, Email: soriver3399@fjmu.edu.cn. Department of Urology, Second Affiliated Hospital, Anhui Medical University, Hefei 230022, China Department of Urology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China State Key Laboratory of Molecular Engineering of Polymers, Key Laboratory of Computational Physical Sciences, Department of Macromolecular Science, Fudan University, Shanghai 200433, China ‡Howard Hughes Medical Institute, Department of Developmental Biology and Department of Pathology, Stanford University, Stanford CA 94305 Department of Chemistry, Stony Brook University, Stony Brook, New York 11794-3400, United States Department of General Surgery Xinhua Hospital Shanghai Jiao Tong University School of Medicine Shanghai China Department of Neurology West China Hospital of Sichuan University Chengdu Sichuan Province China The State Key Laboratory of Advanced Optical Communication Systems and Networks Department of Physics and Astronomy; Shanghai Jiao Tong University; Shanghai 200240; China Beijing National Laboratory for Molecular Sciences, State Key Laboratory for Rare Earth Materials Chemistry and Applications, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China, Structural Chemistry, Stockholm University, SE-10691 Stockholm, Sweden, and State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Institute of Physics and Mathematic, Chinese Academy of Sciences, Wuhan 430071, China Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi 214122, China Zhengzhou Fruit Research Institute, Chinese Academy of Agricultural Sciences Zhengzhou China Guangxi Academy of Agricultural Sciences/Guangxi Key Laboratory of Rice Genetics and Breeding Rice Research Institute Nanning China Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Institute of Functional Nano and Soft Materials (FUNSOM), and Collaborative Innovation Centre of Suzhou Nano Science and Technology, SWC for Synchrotron Radiation Research, Soochow University, Suzhou 215123, P. R. China Department of Respiratory and Critical Care Medicine Division of Pulmonary Diseases, State Key Laboratory of Biotherapy of China West China Hospital of Sichuan University Chengdu China Jin Li, Fudan University Shanghai Cancer Center; Liwei Wang, Shanghai First People’s Hospital; Leizhen Zheng, XinHua Hospital Affiliated to Shanghai Jiaotong University, Shanghai; Shukui Qin, People’s Liberation Army (PLA) Cancer Center, 81st Hospital of PLA; Zhining Fan, Second Affiliated Hospital of Nanjing Medical University; Hao Yu, Nanjing Medical University, Nanjing; Jianming Xu, 307th Hospital of PLA, Academy of Military Medical Sciences; Honggang Zhang, Chinese Academy of Medical Sciences Cancer... The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei‐MOST) & Key Laboratory of Oral Biomedicine Ministry of Education School and Hospital of Stomatology, Wuhan University Wuhan China Endocrinology Peking University First Hospital Beijing China Engineering Research Center of South Upland Agriculture, Southwest University, Ministry of Education, Chongqing 400716, China Department of Gynaecology and Obstetrics The Third Hospital of Xiamen Xiamen China School of Life Sciences Yantai University Yantai China Department of Physiology, Nanjing Medical University, Nanjing 210029, China. chenl@njmu.edu.cn. From the Department of Pathology and Laboratory Medicine, University of Texas Medical School, Houston (Drs Al-Ibraheemi, Chen, Syklawer, Quesada, Wahed, Nedelcu, and Nguyen); Department of Biology, Trinity University, San Antonio, Texas (Ms Pham). bNovartis Pharmaceuticals Corporation, East Hanover, NJ, USA Department of Neurology, Tianjin Huanhu Hospital, Tianjin, China Department of Neurology, Cardio-Neurology Clinic, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA; Department of Neurology, West China Hospital in Sichuan University, Chengdu, China Department of Ultrasound, Peking University First Hospital , Beijing 100034 , PR China Department of Pharmacology, College of Physicians and Surgeons of Columbia University, 630 West 168th Street, New York, NY 10032 Analysis Group, Inc., Boston, MA, USA Department of Respiratory and Critical Care Medicine, Ningbo First Hospital, Ningbo, China College of Information Engineering, Shanghai Maritime University, Shanghai 201306, China Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, 100101, Beijing, China Tianjin Key Laboratory of Structure and Performance for Functional Molecules, College of Chemistry, Tianjin Normal University, Tianjin 300387, China Electric Power Research Institute, State Grid Ningxia Electric Power Co., Ltd., Ningxia 750001, China Department of Radiotherapy Huaihe Hospital of Henan University Kaifeng Henan 475000 China Eli Lilly and Company, Indianapolis, IN, USA; College of Chemistry and Chemical Engineering, Anhui University, No. 111 Jiulong Road, Hefei 230601, P. R. China Department of Pharmacology School of Pharmacy China Medical University Shenyang Liaoning 110122 China The Jackson Laboratory for Genomic Medicine, Farmington, Connecticut, USA State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Disease, Guangzhou, Guangdong 510120, PR China; Department of Anesthesia, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510120, PR China School of Civil Engineering; Guangdong Ocean University Cunjin College; Zhanjiang; P. R. China Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration, Jinan, China School of Materials Science and Engineering, Hefei University of Technology, Hefei 230009, China; Semiconductor and Optoelectronic Technology Engineering Research Center of Anhui Province, Wuhu 241000, China Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, 300052, China; Tianjin Neurological Institute, Tianjin, 300052, China Center on Translational Neuroscience, College of Life and Environmental Sciences, Minzu University of China, Beijing 100081, China Department of Nephrology and Medical Intensive Care, Charité-Universitätsmedizin Berlin, Berlin, Germany; From the Department of Pediatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (L.Z., R.J.); Division of Cardiovascular Diseases, Cardiovascular Research Institute, University of Kansas Medical Center, Kansas City (L.Z., G.C., M.R.A., A.S., Y.-T.X., M.G., Y.Z., A.D., Y.Y., X.C., S.Y., O.-L.W., L.C., J.H., R.J.V., B.D.); and Department of Medicine, Mount Sinai School of Medicine, New York, NY (H.K.E.). Department of Orthodontics, School of Stomatology, Fourth Military Medical University, Xi'an, Shaanxi, People's Republic of China.; Research and Development Center for Tissue Engineering, School of Stomatology, Fourth Military Medical University, Xi'an, Shaanxi, People's Republic of China. State Key Laboratory of Natural Medicines, Department of Organic Chemistry, China Pharmaceutical University, Nanjing 210009, P. R. China Department of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, China; Key Laboratory of Digital Quality Evaluation of Chinese Materia Medica of State Administration of TCM, Guangzhou 510006, China; Engineering & Technology Research Center for Chinese Materia Medica Quality of the Universities of Guangdong Province, Guangzhou 510006, China Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Institute of Functional Nano and Soft Materials (FUNSOM), Joint International Research Laboratory of Carbon-Based Functional Materials and Devices, Soochow University, 199 Ren’ai Road, Suzhou 215123, Jiangsu China; Department of Chemistry, Indiana University Bloomington, 800 E. Kirkwood Avenue, Bloomington, Indiana 47405, United States Department of Neurology, West China Hospital, Sichuan University, Chengdu 610041, China. Department of Ultrasound, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University, No.600 Yishan Road, Shanghai, China Department of Oncology, the Second Affiliated Hospital of Soochow University, Suzhou, China Shanghai Institute of Immunology, Renji Hospital Shanghai Jiao Tong University School of Medicine Shanghai China Department of Intensive Care Unit, Second Affiliated Hospital, School of Medcine, Zhejiang University-Hangzhou 310009, Zhejiang, China; Neurointensive care unit, Second Affiliated Hospital, School of Medcine, Zhejiang University-Hangzhou 310009, Zhejiang. Department of Gastrointestinal Surgery IV, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education) Peking University Cancer Hospital & Institute Beijing China Wright Center for Photovoltaics Innovation and Commercialization, Department of Physics and Astronomy, University of Toledo, Toledo, Ohio 43606, United States Department of Radiation Oncology, Sun Yat‐Sen University Cancer Center, State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Guangzhou People's Republic of China Department of Radiation Oncology, Sun Yat-sen University Cancer Center, the State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangzhou, Guangdong, China Department of Orthopaedics, Affiliated Hospital of Jining Medical University, Jining, China School of Food Science and Biotechnology Zhejiang Gongshang University Hangzhou China Department of Orthopedics, The First Affiliated Hospital of PLA General Hospital (304 Hospital), Beijing 100048, P.R. China Department of Neurosurgery, Shenzhen Key Laboratory of Neurosurgery The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital Shenzhen China The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China Institute of Chinese Sturgeon, China Three Gorges Corporation, Yichang, China;; Hubei Key Laboratory of Three Gorges Project for Conservation of Fishes, Institute of Chinese Sturgeon, China Three Gorges Corporation, Yichang, China State Key Laboratory of Analytical Chemistry for Life Sciences, Jiangsu Key Laboratory of Advanced Organic Materials, School of Chemistry and Chemical Engineering, Chemistry and Biomedicine Innovation Center (ChemBIC), Nanjing University, Nanjing 210023, China School of Automation & Electrical Engineering, Lanzhou Jiaotong University, Lanzhou 730070, China Department of Critical Care Medicine, The Sixth Affiliated Hospital, Sun Yat-sen University , Guangzhou, Guangdong, P. R. China National Institute for Advanced Materials, School of Materials Science and Engineering, Smart Sensing Interdisciplinary Science Center, Nankai University, Tianjin 300350, China Department of Pathology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Kongjiang Road 1665, Shanghai 200092, China Department of Urology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China. Institute of Nutrition & Health, Qingdao University, Qingdao, Shandong 266071, People’s Republic of China; School of Public Health, Qingdao University, Qingdao, Shandong 266071, People’s Republic of China Institute of Hematology, Union Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan China The First Hospital of Jilin University, Changchun, Jilin 130021, China School of Environmental Science and Engineering, Sun Yat-sen University, Guangzhou 510006, China Department of Neurosurgery, Southern Medical University, Zhujiang Hospital, Guangzhou, China.; National Key Clinic Department, Key Laboratory on Brain Function Repair and Regeneration of Guangdong, Southern Medical University, Guangzhou, China.; Neurosurgery Institute, Key Laboratory on Brain Function Repair and Regeneration of Guangdong, Southern Medical University, Guangzhou, China. Department of Hematology, Affiliated Hospital of Weifang Medical University, Weifang, Shandong 261031, P.R. China Departments of Pathology (S.C.C., L.C., K.H.B., M.M.M.) Texas 77030 Nanjing University of Science and Technology State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Institute of Physics and Mathematics, The Chinese Academy of Sciences, Wuhan 430071, People's Republic of China State Key Laboratory of Marine Environmental Science; Key Laboratory of the Ministry of Education for Coastal and Wetland Ecosystems; College of the Environment and Ecology; Xiamen University; Xiamen 361005; China Department of Anesthesiology Qian Xi Nan People's Hospital Qianxinan Guizhou China Department of Cardiac Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021 Shandong, China College of Engineering; Zhejiang A & F University; Hangzhou 311300; China Center for Molecular Imaging and Nuclear Medicine, School for Radiological and Interdisciplinary Sciences (RAD-X), Soochow University, Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Suzhou 215123, China Institute of Agro-products Processing, Anhui Academy of Agricultural Sciences, Hefei, China. Key Laboratory for Supramolecular Structure and Material of Ministry of Education of China, Jilin University, Changchun, 130012, P. R. China (W.X., S.X., Z.L., L.C., B.Z.); and Department of Chemistry, School of Science and Technology, Kwansei-Gakuin University, Sanda, Hyogo 669-1337, Japan (Y.O.) Jiangsu Yew Pharmaceutical Co., Ltd. Hodo Group Wuxi 214199 China Key Laboratory of Carbohydrate Chemistry and Biotechnology, School of Biotechnology, Jiangnan University, Wuxi, China; Key Laboratory of Functional Materials Physics and Chemistry, Jilin Normal University, Ministry of Education, Siping 136000, P. R. China Department of Ultrasound, Peking University First Hospital, Beijing, People’s Republic of China College of Chemistry and Chemical Engineering in Anhui University and Key Laboratory of Functional Inorganic Materials Chemistry of Anhui Province, Anhui Province Key Laboratory of Chemistry for Inorganic/Organic Hybrid Functionalized Materials, Key Laboratory of Structure and Functional Regulation of Hybrid Materials (Anhui University) Ministry of Education; Faculty of Health Sciences, Institute of Physical Science and Information Technology, Anhui University, 230039 Hefei, China Key Laboratory of Digital Quality Evaluation of Chinese Materia Medica of State Administration of TCM, China; Engineering and Technology Research Center for Chinese Materia Medical Quality of the Universities of Guangdong Province Guangdong Pharmaceutical University Guangzhou China State Environmental Protection Key Laboratory of Sources and Control of Air Pollution Complex, Beijing 100084, China. Laboratory of Heat and Mass Transport at Micro-Nano Scale, College of Engineering, Peking University, Beijing 100871, China; School of Mathematical Sciences, Peking University, Beijing 100871, China The State Key Laboratory of Mechanics and Control of the Mechanical Structures, College of Aerospace Engineering, Nanjing University of Aeronautics and Astronautics , Nanjing 210016, China Department of Animal Science, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, China; Key Laboratory of Livestock and Poultry Multiomics, Ministry of Agriculture and Rural Affairs, College of Animal and Technology (Institute of Animal Genetics and Breeding), Sichuan Agricultural University, Chengdu, China Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi 214122, China; National Engineering Research Center for Cereal Fermentation and Food Biomanufacturing, Jiangnan University, Wuxi 214122, China; Jiangsu Provincial Research Center for Bioactive Product Processing Technology, Jiangnan University, Wuxi 214122, China National Synchrotron Radiation Laboratory & Department of Physics, University of Science & Technology of China, Hefei, Anhui 230026, China Guangdong Provincial Research Center for Environment Pollution Control and Remediation Materials, College of Life Science and Technology, Jinan University, 510632, Guangzhou, China Key Laboratory of Livestock and Poultry Multi-Omics, Ministry of Agriculture and Rural Affairs, College of Animal and Technology, Sichuan Agricultural University, Chengdu 611130, China; Farm Animal Genetic Resource Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, China Sun Yat‐sen University Cancer Center the State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy Center for Precision Medicine of Sun Yat‐sen University Guangzhou 510060 P. R. China; Department of Radiation Oncology Sun Yat‐sen University Cancer Center Guangzhou 510060 P. R. China West China Hospital of Sichuan University, Neurology, Chengdu 610041, P. R. China. Department of Hepatobiliary Surgery, Peking University People’s Hospital, Beijing, China. Division of Pulmonary Diseases, Department of Respiratory and Critical Care Medicine, State Key Laboratory of Biotherapy of China West China Hospital of Sichuan University Chengdu China Institute for Agri-food Standards and Testing Technology, Shanghai Academy of Agricultural Sciences, Shanghai, China; Shanghai Co-Elite Agri-food Testing Technical Service Co. Ltd, Shanghai, China Hangzhou Dianzi University, Hangzhou, Zhejiang, China Sun Yat‐sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center of Cancer MedicineGuangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy Guangzhou China Liaoning Tiansheng Engineering Technology Co., Ltd., Dalian 116001, China Joint Centre of Translational Medicine, the First Affiliated Hospital of Wenzhou Medical University Wenzhou Institute University of Chinese Academy of Sciences Wenzhou Zhejiang 325001 China; Center of Materials Science and Optoelectronics Engineering College of Materials Science and Opto‐Electronic Technology University of Chinese Academy of Sciences Beijing 100049 China Department of General Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China National Key Laboratory for Germplasm Innovation and Utilization of Horticultural Crops, Zhengzhou Fruit Research Institute Chinese Academy of Agricultural Sciences Zhengzhou Henan China School of the Environment; Northeast Normal University; Changchun 130024; P. R. China School of Science and Technology, Shandong University of Traditional Chinese Medicine, Jinan 250355, China Department of Gastrointestinal Surgery, Hubei Cancer Hospital, Wuhan, Hubei, China Department of Ophthalmology, the First Affiliated Hospital of Soochow University, Suzhou 215006, Jiangsu Province, China. Department of Ultrasound in Medicine, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai, China. Department of Radiology, Tongji Medical College, Union Hospital Huazhong University of Science and Technology Wuhan China; Department of Interventional Radiology, Tongji Medical College, Union Hospital Huazhong University of Science and Technology Wuhan China XiangXue Life Sciences Research Center, XiangXue Pharmaceutical Co. Ltd, Guangzhou, PR China Department of Medical Oncology Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital) Hangzhou PR China; Institute of Cancer and Basic Medicine Chinese Academy of Sciences Hangzhou PR China Key Laboratory of Carbohydrate Chemistry and Biotechnology, School of Biotechnology, Jiangnan University, Wuxi, Jiangsu 214122, People’s Republic of China Liaoning Diabetic Eye Center, Shenyang 110001, Liaoning Province, China. Department of Lab Medicine, Yantai Yuhuangding Hospital, Yantai, Shandong, China. Department of Chemistry, National Taiwan University, Taipei 106, Taiwan, and National Synchrotron Radiation Laboratory and Structure Research Laboratory, University of Science & Technology of China, Hefei 230026, China Merck & Co., Inc., Kenilworth, New Jersey 07033, United States School of Environment; Tsinghua University; Beijing 100084, China Haisco Pharmaceuticals Group Co. Ltd., 136 Baili Road, Wenjiang District, Chengdu 611130, China Department of Chemistry, University of Michigan, 930 North University Avenue, Ann Arbor, Michigan 48109-1055, United States Division of Pulmonary Diseases, State Key Laboratory of Biotherapy of China and Department of Respiratory Medicine, West China Hospital, Sichuan University, Chengdu 610041, China Department of Nephrology, Hefei Jinnan Kidney Hospital, Hefei, China Dialysis Department of Nephrology Hospital, the First Affiliated Hospital of Xi’an Jiaotong University, Xi’an , Shaanxi, China Division of Nephrology Shanghai No. 1 People's Hospital, Shanghai Jiao Tong University Shanghai China State Key Laboratory of Microbial Technology Shandong University Jinan China Department of Medicine, Cardiovascular Division, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.; Department of Cardiology, Xiangya Hospital, Central South University, 0731 Changsha, Hunan, China. Department of Cardiology, Affiliated Hospital of Xuzhou Medical University, Xuzhou 221002, China State Key Lab of Transducer Technology, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, 865 Changning Road, Shanghai 200050, China; University of Chinese Academy of Sciences, 19 Yuquan Road, Beijing 100039, China School of Life Sciences, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China Nanjing Tuodao Medical Technology Co., Ltd., Nanjing 210012, China Department of Neurosurgery, l0lst Hospital of PLA, Wuxi, Jiangsu 214044, P.R. China Department of Orthopaedics Surgery, Wuhan General Hospital of Guangzhou Command, Wuhan, China Department of Gastroenterology, Southwest Hospital, Third Military Medical University, Chongqing, P. R. China Joint Centre of Translational Medicine the First Affiliated Hospital of Wenzhou Medical University Wenzhou Institute University of Chinese Academy of Sciences Wenzhou Zhejiang 325001 China; Center of Materials Science and Optoelectronics Engineering College of Materials Science and Opto‐Electronic Technology University of Chinese Academy of Sciences Beijing 100049 China Division of Oncology, Cancer Hospital of Shantou University Medical College, Shantou, China 1National Center for Liver Cancer, Shanghai, PR China.; 2International Cooperation Laboratory on Signal Transduction, Eastern Hepatobiliary Surgery Institute, Second Military Medical University, Shanghai, PR China. The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), The First Clinical College of Zhejiang Chinese Medical University, Hangzhou, China. Department of Anatomy, Histology and Embryology, K. K. Leung Brain Research Centre, The Fourth Military Medical University, Xi'an, China; Department of Ultrasound, Armed Police Tianjin Corps Hospital, Tianjin, China GE Global Research-Shanghai 1 Coal Polygeneration Technologies Laboratory, , Shanghai 201203, China Department of Hemodialysis The First Affiliated Hospital of Xi'an Jiaotong University Xi'an China Key Laboratory of Laboratory Medical Diagnostics, Ministry of Education, Chongqing Medical University, Chongqing 400016, China. Shenzhen Research Institute the Chinese University of Hong Kong Shenzhen 518000 China Surgical Department I (Urology Department) Shanghai University of Traditional Chinese Medicine Affiliated LONGHUA Hospital Shanghai China Department of Cardiology, The Second Affiliated Hospital of Hainan Medical University, Haikou, Hainan, China Department of Neurology, Tianjin Huanhu Hospital, China College of Chemistry; State Key Laboratory of Elemento-Organic Chemistry; Nankai University; Tianjin 300071; P. R. China Departments of Neurosurgery Tianjin Fifth Central Hospital Tianjin China Department of Pharmacology, School of Pharmacy, China Medical University, Shenyang 110122, China Department of Neurosurgery, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China. Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China Department of Chemistry; Yale University; New Haven; USA Chongqing Academy of Animal Science Rongchang Chongqing China Tribology Research Institute, Key Laboratory of Advanced Technology of Materials, Ministry of Education, Southwest Jiaotong University, Chengdu 610031, China Shanghai Maritime University, Shanghai 201306, China Key Laboratory of Optoelectronic Information and Sensing Technologies of Guangdong Higher Education Institutes, Guangdong Provincial Key Laboratory of Optical Fiber Sensing and Communications, College of Science & Engineering, Jinan University, Guangzhou 510632, China Department of Plant Biology and Ecology, College of Life Science Nankai University , Tianjin 300071 China The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei‐MOST) and Key Laboratory of Oral Biomedicine Ministry of Education School and Hospital of Stomatology Wuhan University Wuhan China State Key Laboratory of Vegetation and Environmental Change, Institute of Botany, Chinese Academy of Sciences, China School of Aeronautics and Astronautics, Central South University, Changsha 410083, China College of Food Science; Fujian Agriculture and Forestry University; Fuzhou 350002; China Department of Genetics, Rutgers University, Piscataway, NJ, 08854 College of Civil Engineering and Architecture, Wuhan University of Technology, China; China Construction First Building (Group) Corporation Limited, Beijing, China Department of Pharmacognosy, School of Pharmacy, Fudan University, 138 Yi Xue Yuan Road, Shanghai 200032, People's Republic of China, Laboratory of Phytochemistry, Kunming Institute of Botany, Academia Sinica, Kunming 650204, Yunnan, People's Republic of China, and Natural Products Laboratory, Division of Medicinal Chemistry and Natural Products, School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina 27599 College of Food Science and Technology, Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety, Guangdong Province Engineering Laboratory for Marine Biological Products, Guangdong Provincial Engineering Technology Research Center of Seafood, Key Laboratory of Advanced Processing of Aquatic Product of Guangdong Higher Education Institution Guangdong Ocean University Zhanjiang China Department of Medicinal Chemistry, Merck Research Laboratories, 126 East Lincoln Avenue, Rahway New Jersey 07065, United States Tribology Research Institute, Key Laboratory of Advanced Technologies of Materials (Ministry of Education), Southwest Jiaotong University, Chengdu 610031, China Department of Medicine, Cardiovascular Division, Brigham and Women’s Hospital, Harvard Medical School, Boston, United States; Department of Cardiovascular Surgery, The Second Xiangya Hospital, Central South University, Changsha, China Department of Pharmacology School of Pharmaceutical Sciences Central South University Changsha 410078 China MOE Engineering Research Center of Forestry Biomass Materials and Bioenergy Research Center of Biomass Clean Utilization Beijing Key Laboratory of Lignocellulosic Chemistry College of Materials Science and Technology Beijing Forestry University Beijing 100083 P.R. China Department of Cardiology, Benxi Central Hospital, Benxi, Liaoning Province, 117000, China From the Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia. School of Physics and Materials Science, Guangzhou University, Guangzhou 510006, China Key Laboratory of Pig Industry Sciences (Ministry of Agriculture), Chongqing Academy of Animal Science, Chongqing, China Department of Hand Surgery The First Hospital of Jilin University 71 XinMin Street Changchun 130021 P. R. China State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Institute of Physics and Mathematics, the Chinese Academy of Sciences, Wuhan 430071, China Department of Burn, Wound Repair & Reconstruction, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong 510080, China; Guangdong Provincial Engineering Technology Research Center of Burn and Wound Accurate Diagnosis and Treatment Key Technology and Series of Products, Sun Yat-Sen University, Guangzhou, Guangdong 510080, China; Institute of Precision Medicine, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong 510080, China Center for Molecular Imaging and Nuclear Medicine, State Key Laboratory of Radiation Medicine and Protection School for Radiological and Interdisciplinary Sciences (RAD‐X), Soochow University, Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions Suzhou China State Key Laboratory of Analytical Chemistry for Life Sciences Jiangsu Key Laboratory of Advanced Organic Materials School of Chemistry and Chemical Engineering Nanjing University 163 Xianlin Avenue Nanjing 210023 P. R. China Interdisciplinary Research Center of Low-carbon Technology and Equipment, College of Mechanical and Vehicle Engineering, Hunan University, Changsha 410082, P. R. China Interdisciplinary Research Center of Low-carbon Technology and Equipment, College of Mechanical and Vehicle Engineering, Hunan University, Changsha410082, P. R. China Department of Anesthesiology Peking University Third Hospital Beijing China Department of Chemistry, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, State Key Laboratory of Molecular Engineering of Polymers and Laboratory of Advanced Materials, Fudan University, Shanghai 200433, People’s Republic of China State Key Laboratory of Genetic Resources and Evolution Kunming Institute of Zoology Chinese Academy of Sciences Kunming Department of Burns Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, Guangdong, China Department of Physical Education, Shanghai Jiaotong University, Shanghai, China for the ORIENT-16 Investigators Center for Gene Therapy The Research Institute at Nationwide Children's Hospital Columbus OH USA Key Laboratory of Preparation and Applications of Environmental Friendly Materials, Ministry of Education, Jilin Normal University, Siping 136000, P. R. China Department of Respiratory and Critical Care Medicine, West China Hospital, West China School of Medicine, Sichuan University, Chengdu, Sichuan 610041, China Division of Vital Statistics, Institute of Health Information, Shanghai Municipal Center for Disease Control and Prevention, Shanghai 200336, China College of Computer Science and Technology, Zhejiang University of Technology, Hangzhou 310023, China School of Pharmaceutical Science & Technology, Tianjin University, 92 Weijin Road, Tianjin 300072, China State Key Laboratory of Coordination Chemistry; Nanjing National Laboratory of Microstructures; School of Chemistry and Chemical Engineering; Nanjing University; Nanjing 210093 Department of Mechanical Engineering University of Michigan−Dearborn Dearborn MI 48128 USA Department of Vascular Surgery, Fu Xing Hospital, Capital Medical University, Beijing 100045, China Department of Neurology and Research Center of Neurology in Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China; Key Laboratory of Medical Neurobiology of Zhejiang Province, Zhejiang University School of Medicine, Hangzhou, China Department of Orthopaedics, Ward 2, The First Affiliated Hospital of the Medical College, Shihezi University, Shihezi, Xinjiang, China (mainland) Department of Psychiatry The Chinese University of Hong Kong Hong Kong China School of Civil Engineering of Nanjing Forestry University, Nanjing 210037, China State Key Laboratory of Radiation Medicine and Protection; Soochow University; Suzhou; China; Center for Molecular Imaging and Nuclear Medicine Department of Ultrasound in Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Institute of Ultrasound in Medicine, Shanghai 200233, P.R. China Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA The First Dongguan Affiliated Hospital of Guangdong Medical University, Dongguan, Guangdong Province, China School of Environment, Beijing Normal University, Beijing 100875, China. State Key Laboratory of Water Environment Simulation and Pollutant Control, Beijing 100875, China. Center for Stem Cell and Translational Medicine, School of Life Sciences, Anhui University, Hefei City, Anhui, China Institute of Food and Nutraceutical Science, School of Agriculture and Biology School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, China State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Collaborative Innovation Center of Advanced Microstructures, Nanjing University, Nanjing 210023, People’s Republic of China College of Animal Science and Technology Shihezi University Shihezi China Department of Physiology Nanjing Medical University Nanjing Jiangsu China Jiangsu Key Laboratory of Advanced Catalytic Materials & Technology, School of Petrochemical Engineering, Changzhou University, Changzhou, Jiangsu 213164, People’s Republic of China Department of Pathology and Laboratory Medicine, The University of Texas Health Science Center McGovern Medical School, Houston, TX, USA. HEC Research and Development Center, HEC Pharm Group, Dongguan 523871, P.R. China Department of Otorhinolaryngology Head and Neck Surgery, Chinese PLA General Hospital, Beijing, China; International Cooperation Laboratory on Signal Transduction, Eastern Hepatobiliary Surgery Institute, Second Military Medical University, Shanghai 200438, China Authors' Affiliations: 1Molecular Oncology Laboratory, and Departments of 2Comprehensive Treatment and 3Radio-intervention Therapy, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, PR China Department of Neurosurgery, Fudan University Shanghai Cancer Center; Department of Oncology Shanghai Medical College, Fudan University Shanghai China Key Laboratory of Agricultural Microbiology, College of Plant Protection Shandong Agricultural University Tai'an China; State Key Laboratory of Crop Biology Shandong Agricultural University Tai'an China , , , Department of Stomatology, The Fifth Hospital of Harbin, Harbin, P.R. China School of Life Sciences Yantai University Yantai Shandong China Department of Chemistry, Rensselaer Polytechnic Institute, Troy, New York 12180 Department of General Surgery Xinhua Hospital, Affiliated to School of Medicine Shanghai Jiao Tong University China School of Materials Science and Engineering, Xi’an University of Technology, No. 5 Jinhua South Road, Xi’an, Shaanxi province 710048, P.R. China Department of Orthopaedics, The People’s Hospital of Rizhao, Rizhao, Shandong, China (mainland) School of Chinese Materia Medica and Yunnan Key Laboratory of Southern Medicinal Utilization, Yunnan University of Traditional Chinese Medicine Shanghai Diabetes Institute, No.6 People's Hospital Affiliated to Shanghai Jiaotong University, Shanghai 200233, China. Shanghai University of Medicine & Health Science Affiliated Zhoupu Hospital, Shanghai, China; Shanghai University of Traditional Chinese Medicine, Shanghai, China Department of Neurosurgery, The Fifth Central Hospital of Tianjin, Tianjin 300450, P.R. China College of Mechanical and Electrical Engineering, Harbin Engineering University, Harbin 150001, China Department of Chemistry, Fudan University, 220 Handan Road, Shanghai 200433, China Cardiothoracic Surgery The Second Affiliated Hospital of Soochow University Suzhou China State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X) and Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, 199 Ren’ai Road, Suzhou 215123, China Department of Pathology, University of Texas-Houston Medical School, Houston, TX, USA Department of Thoracic Surgery, Chinese PLA General Hospital, Beijing, China Department of Orthopedics, First Affiliated Hospital of Fujian Medical University, Fuzhou Fujian 350004, PR China. School of Electrical and Electronic Engineering, Nanyang Technological University, Singapore, Singapore Institute of Functional Nano & Soft Materials (FUNSOM) and Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou, Jiangsu 215123, China Department of Ophthalmology The First Affiliated Hospital of China Medical University Shenyang Liaoning China State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Wuhan 430079, China Department of Physics, City University of Hong Kong, Hong Kong SAR, China; School of Medicine, Yangzhou University, Yangzhou 225001, China Washoe County Health District, Reno, Nevada, USA Orthopaedic Center, The First Affiliated Hospital of Shihezi University Medical College, Shihezi, Xinjiang 832008, China Tribology Research Institute; Key Laboratory of Advanced Technology of Materials; Ministry of Education; Southwest Jiaotong University; Chengdu 610031 State Key Laboratory of Oncology in South China Department of Radiation Oncology Sun Yat‐sen University Cancer Center Collaborative Innovation Center for Cancer Medicine Guangzhou China Department of Anesthesiology, Affiliated Hospital of Hebei University, Baoding City, Hebei Province, China. School of International Pharmaceutical Business, China Pharmaceutical University, No.639 Longmian Avenue, Jiangning District, Nanjing, Jiangsu, China School of Science, Jiangsu University of Science and Technology, Zhenjiang, 212003, China Molecular Neuroscience and Vascular Biology Laboratory, Department of Neurosurgery and Department of Radiation Oncology, Sun Yat‐sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy Guangzhou China Eastern Hepatobiliary Surgery Hospital/Institute of Shanghai, Shanghai, 200131 China Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine, 200025 Shanghai, China;; Faculty of Basic Medicine, Shanghai Jiao Tong University School of Medicine, 200025 Shanghai, China;; Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, 200025 Shanghai, China; School of Pharmacy, Yantai University, Yantai, PR China 1Department of Cell and Developmental Biology, Vanderbilt University, Nashville, Tennessee. Department of Imaging & Pathology, Biomedical Sciences Group, KU Leuven, Leuven, Flanders, Belgium Southwest Medical University, Luzhou Neurosurgical Department The First Affiliated Hospital of Shenzhen University Shenzhen Second People’s Hospital Shenzhen China Key Laboratory of Applied Chemistry of Chongqing Municipality, School of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, China State Key Laboratory of Microbial Technology; Shandong University; Jinan China State Key Laboratory of Fine Chemical Engineering and School of Life Science and Biotechnology, Dalian University of Technology, Dalian 116024, China Key Laboratory of Basic Pharmacology of Guizhou Province and School of Pharmacy, Zunyi Medical University, Zunyi 563000, China; Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnomedicine of Ministry of Education, Zunyi Medical University, Zunyi 563000, China Key Laboratory of Genomic and Precision Medicine, Collaborative Innovation Center of Genetics and Development, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China;; University of Chinese Academy of Sciences, Beijing, China; Department of Hepatobiliary Surgery, Yinzhou People's Hospital Affiliated to Ningbo University School of Medicine, Ningbo, Zhejiang 315040, P.R. China Animal Biotechnology Center, College of Veterinary Medicine of Sichuan Agricultural University, Ya’an 625014, China Shandong Key Laboratory of Animal Disease Control and Breeding, Institute of Animal Science and Veterinary Medicine, Shandong Academy of Agricultural Sciences, Jinan, China Rice Research Institute of Sichuan Agricultural University Chengdu China Dialysis Department of Nephrology Hospital; The First Affiliated Hospital of Xi'an Jiaotong University; Xi'an 710061; China Authors' Affiliations: 1The International Cooperation Laboratory on Signal Transduction of Eastern Hepatobiliary Surgery Institute and 2The Department of Gastroenterology of Changzheng Hospital, Second Military Medical University, Shanghai, China Department of Biological Science and Biotechnology, Tsinghua University, Beijing, 100084, China. State Key Laboratory of Vegetation and Environmental Change, Institute of Botany, Chinese Academy of Sciences, Beijing 100093, People's Republic of China College of life sciences, Zhejiang Sci-Tech University, Hangzhou, Zhejiang, China NanoStructure Laboratory, Department of Electrical Engineering, Princeton University, Princeton, New Jersey 08544 Key Laboratory of Pig Industry Sciences (Ministry of Agriculture), Chongqing Academy of Animal Science, Chongqing, PR China Department of Immunology, Genetics and Pathology, Science for Laboratory Uppsala University Uppsala Sweden; Rarity Bioscience AB Uppsala Sweden Department of Chemistry, National Taiwan University, Taipei 106, Taiwan, School of Materials Science and Engineering, Hefei University of Technology, Hefei 230009, China, Institute of Electro-optical Science and Technology and Department of Physics, National Taiwan Normal University, Taipei 116, Taiwan Zhengzhou Fruit Research Institute, Chinese Academy of Agricultural Sciences Zhengzhou China; National Horticultural Germplasm Resources Center, Chinese Academy of Agricultural Sciences Zhengzhou China State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD‐X) and Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions Soochow University Suzhou 215123 China Navy Clinical College, Anhui Medical University, Beijing 100048; Department of Obstetrics and Gynecology, PLA Navy General Hospital, Beijing 100048, China. *Corresponding author, E-mail: 3313400243@qq.com. EPI Department, Yuzhong Distinct Center for Disease Control and Prevention, Chongqing, China Laboratory of Synthetic Microbiology; School of Chemical Engineering & Technology; Tianjin University; Tianjin 300072; P. R. China Surgical Department I (Urology Department) LongHua Hospital Shanghai University of Traditional Chinese Medicine China The First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, P. R. China State Key Laboratory of Plant Genomics and National Center for Plant Gene Research, Institute of Genetics and Developmental Biology The Chinese Academy of Sciences Beijing 100101 China Chongqing Academy of Animal Science, 402460 Chongqing, China; Department of Pathology and Laboratory Medicine, The University of Texas Health Science Center at Houston State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of Ceramics Chinese Academy of Sciences Shanghai 200050 P. R. China Department of Anatomy and Cell Biology and Department of Pharmacology, University of Illinois, Chicago, IL 60612; and Faculty of Bioscience and Biotechnology, Tokyo Institute of Technology, Nagatsuta-cho, Midori-ku, Yokohama 226-8501, Japan Department of Burns, Laboratory of General Surgery The First Affiliated Hospital, SunYat‐Sen University Guangzhou China; Guangdong Provincial Engineering Technology Research Center of Burn and Wound Accurate Diagnosis and Treatment Key Technology and Series of Products SunYat‐Sen University Guangzhou China; Institute of Precision Medicine The First Affiliated Hospital, SunYat‐Sen University Guangzhou China Department of Pediatrics, The Affi liated Hospital of Qingdao University Medical College, Qingdao 266003, P.R. China Department of Medical Oncology, Affiliated Cancer Hospital of Shantou University Medical College, Shantou, Guangdong, China Tribology Research Institute State Key Laboratory of Traction Power School of Mechanical Engineering Southwest Jiaotong University 610031 Chengdu China Department of Pharmacology, School of Pharmacy China Medical University Shenyang China Hebei Key Laboratory of Gastroenterology Department of Gastroenterology Hebei Institute of Gastroenterology The Second Hospital of Hebei Medical University Shijiazhuang Hebei China College of Pharmacy, Hubei University of Chinese Medicine, Wuhan 430065, China Department of Neurosurgery, Shenzhen Key Laboratory of Neurosurgery the First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital 3002# Sungang Road, Futian District Shenzhen 518035 China Department of Pharmacy, Fuzhou General Hospital of Nanjing Military Region, Fuzhou 350025, China. chen1974lei@sina.com Department of Orthopaedics, The Second Hospital of Anhui Medical University: Hefei 230601, China School of Life Science & Biotechnology; Dalian University of Technology; Dalian China Department of Mechanical Engineering, Tsinghua University, Beijing 100084, P.R. China Department of Stomatology, Xiangya Hospital, Central South University, Changsha, China. Department of Endocrinology, Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Suzhou, China Department of Nephrology and Medical Intensive Care Charité‐Universitätsmedizin Berlin Germany The First Hospital of Jilin University, Changchun 130000, China Department of Entomology Nanjing Agricultural University Nanjing Jiangsu 210095 China Bio-X Institutes, Shanghai Jiao Tong University, Shanghai, China State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology Chinese Academy of Sciences Kunming 650223 China; University of Chinese Academy of Sciences Beijing 100049 China National Institute for Advanced Materials, School of Materials Science and Engineering, Nankai University, Tianjin 300350, China; Key Laboratory of Advanced Energy Materials Chemistry (Ministry of Education), Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Nankai University, Tianjin 300071, China International Cooperation Laboratory on Signal Transduction,Eastern Hepatobiliary Surgery Institute/Hospital,Shanghai,China Department of Otorhinolaryngology/Head and Neck Surgery, Chinese People’s Liberation Army General Hospital, Beijing Jilin Province Power Hospital, China Jiangsu Key Laboratory of Marine Bioresources and Environment/Jiangsu Key Laboratory of Marine Biotechnology, Jiangsu Ocean University, Lianyungang, People’s Republic of China; Co-Innovation Center of Jiangsu Marine Bio-industry Technology, Jiangsu Ocean University, Lianyungang, People’s Republic of China The Philips Institute of Oral and Craniofacial Molecular Biology, Virginia Commonwealth University, Richmond, VA 23298-0566, USA Laboratory of Bone Tissue Engineering, Beijing Laboratory of Biomedical Materials, Beijing Research Institute of Orthopaedics and Traumatology, Beijing JiShuiTan Hospital, Beijing 100035, P.R. China State Key Laboratory of Food Science and Technology Nanchang University Nanchang China Surgical Department I (Urology Department), LONGHUA Hospital Shanghai University of Traditional Chinese Medicine, Shanghai, China Department of Orthodontics, School of Stomatology, Shandong University, Jinan 250012, China. Department of Anesthesiology; Ruijin Hospital; Shanghai Jiao-Tong University School of Medicine (SJTU-SM); Shanghai, People's Republic of China Department of Clinical Pharmacology School of Pharmacy China Medical University Shenyang China Research and Development Center for Tissue Engineering, School of Stomatology, The Fourth Military Medical University, Xi'an, People's Republic of China.; Department of Oral Histology and Pathology, School of Stomatology, The Fourth Military Medical University, Xi'an, People's Republic of China.; Department of Orthodontics, School of Stomatology, The Fourth Military Medical University, Xi'an, People's Republic of China. Department of Respiratory and Critical Care Medicine, Tongji Hospital of Tongji Medical College Huazhong University of Science and Technology Wuhan China State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X) and Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou 215123, China School of Life Sciences; Anhui University; Hefei; PR China Department of Neurosurgery, Hunan Provincial People's Hospital, (The First Affiliated Hospital of Hunan Normal University), Changsha, China. Jiangsu Key Laboratory of Advanced Catalytic Materials and Technology Changzhou University Changzhou China Department of Physics, Tsinghua-Foxconn Nanotechnology Research Center, Tsinghua University, Beijing 100084, China Pancreas Center, Department of General Surgery The First Affiliated Hospital of Nanjing Medical University Nanjing Jiangsu People's Republic of China; Pancreas Institute of Nanjing Medical University Nanjing Jiangsu People's Republic of China College of Food Science and Technology; Huazhong Agricultural University; Wuhan 430070; PR China Department of Oncology Renmin Hospital of Wuhan University Wuhan China Department of Materials Science and Engineering, National University of Singapore, 7 Engineering Drive 1, 117574 Singapore Department of Dermatology, State Key Laboratory of Biotherapy and Cancer Center, National Clinical Research Center for Geriatrics, West China Hospital, West China School of Pharmacy, Sichuan University, Chengdu 610041, China Renmin Hospital of Wuhan University Wuhan China Department of Physiology; Qingdao University; Qingdao 266071; China School of Environmental and Chemical Engineering; Jiangsu University of Science and Technology; Zhenjiang 212003; P. R. China Jackson Laboratory for Genomic Medicine, Farmington, Connecticut, USA Department of Neurosurgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of Ceramics Chinese Academy of Sciences Shanghai 200050 China Cancer Hospital of Shantou University Medical College, Guangdong Province, People’s Republic of China Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi 214122, China; National Engineering Research Center of Cereal Fermentation and Food Biomanufacturing, Jiangnan University, Wuxi 214122, China Department of Pathology and Laboratory Medicine, University of Texas Health Science Center at Houston, Houston, TX 77030, USA School of Applied Mathematics, Guangdong University of Technology, Guangzhou, 51000, China Department of Neurosurgery, Sanbo Brain Hospital Co., Ltd, Beijing, 100093, China Gynecology and Obstetrics Department of Chemistry; Tongji University; Shanghai, China CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety & CAS Center for Excellent in Nanoscience, Institute of High Energy Physics and National Center for Nanoscience and Technology of China, Chinese Academy of Sciences, Beijing 100049, China Department of Psychology Nanjing University State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of Ceramics Chinese Academy of Sciences 1295 Dingxi Road Shanghai 200050 P. R. China; Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of Sciences 19A Yuquan Road Beijing 100049 P. R. China Division of Pulmonary Diseases, State Key Laboratory of Biotherapy of China and Department of Respiratory and Critical Care Medicine, West China Hospital of Sichuan University, Chengdu 610041, China State Key Laboratory of Information Photonics and Optical Communications; Beijing University of Posts and Telecommunications; Beijing 100876; China Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing City, China Department of Physiology, School of Basic Medicine, Qingdao University, Qingdao, China Shanghai Diabetes Institute, Shanghai Jiaotong University No. 6 People’s Hospital, Shanghai, China; Department of Endocrinology and Metabolism, Shanghai Jiaotong University No. 6 People’s Hospital, Shanghai, China Department of Pathology and Laboratory Medicine The University of Texas Health Science Center Houston Texas USA; Department of Laboratory Medicine The University of Texas MD Anderson Cancer Center Houston Texas USA Section of Pediatric Emergency Medicine, Department of Pediatrics, Yale University School of Medicine State Key Laboratory of Natural Medicines, School of Science, China Pharmaceutical University, Nanjing, 210009, P.R. China School of Life Science, Yantai University, Yantai 264005, China Department of Gastroenterology, Southwest Hospital, Army Medical University (Third Military Medical University), Chongqing 400038, China |
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