http://rdf.ncbi.nlm.nih.gov/pubchem/author/MD5_13c37f9081ca074b131a3dc44857ca37
Outgoing Links
Predicate | Object |
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family-name | Zheng Wang Wang |
name | Zheng Wang |
given-name | Zheng |
organization-name | CAS Key Laboratory of Bio-Medical Diagnostics; Suzhou Institute of Biomedical Engineering and Technology; Chinese Academy of Sciences; Suzhou 215163; China Department of Thoracic Surgery, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, P.R. China Center for Bio/Molecular Science and Engineering Naval Research Laboratory Washington DC USA Department of Hepatobiliary Surgery First Affiliated Hospital of Xi'an Jiaotong University Xi'an 710061 P. R. China School of Chemical Engineering and Energy, Zhengzhou University, Zhengzhou 450001, China Department of Biology, Duke University, Durham, NC 27708 1 National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China 1 Department of Psychiatry, the First Affiliated Hospital, College of Medicine, Zhejiang University; The Key Laboratory of Mental Disorder's Management of Zhejiang Province; Brain Research Institute of Zhejiang University Institute of Neuroscience CAS Center for Excellence in Brain Science and Intelligence Technology Chinese Academy of Sciences Shanghai China; University of Chinese Academy of Sciences Beijing China Department of Plastic Surgery Peking University Third Hospital Beijing China Department of Electrical and Computer Engineering, University of Texas at Austin, 2501 Speedway, Austin, Texas 78712, United States Department of Mechanical and Energy Engineering, Southern University of Science and Technology, Shenzhen 518055, China. Department of Biostatistics, Yale University, New Haven, CT Department of Biotherapy of PLA 455 Hospital, Shanghai, People's Republic of China State Key Laboratory of Solidification Processing Center of Advanced Lubrication and Seal Materials School of Materials Science and Engineering Northwestern Polytechnical University Xi'an 710072 China Department of Trauma and Microscopic Orthopedics, Zhongnan Hospital of Wuhan University, Wuhan Hubei, 430071, P.R.China. Wenhua Liang, Jiaxi He, Jianfei Shen, Qihua He, Jianrong Zhang, and Jianxing He, The First Affiliated Hospital of Guangzhou Medical University; Wenhua Liang, Jiaxi He, Jianfei Shen, Qihua He, Jianrong Zhang, and Jianxing He, Guangzhou Institute of Respiratory Disease & China State Key Laboratory of Respiratory Disease; Zhihua Zhu, Cancer Center of Sun Yat-Sen University; Qian Zhou, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou; Jianfei Shen, Taizhou Hospital of Zhejiang Province,... North China University of Water Resources and Electric Power, Zhengzhou 450046, China State Key Laboratory of Vegetable Biobreeding, Beijing Vegetable Research Center Beijing Academy of Agriculture and Forestry Science Beijing China Trinity Life Sciences, Waltham, MA. Department of Psychiatry The First Affiliated Hospital, Zhejiang University School of Medicine Hangzhou China; The Key Laboratory of Mental Disorder Management in Zhejiang Province Hangzhou China Department of Thoracic Surgery The Affiliated Hospital of Xuzhou Medical University Xuzhou China Department of Ophthalmology Yichang Central People's Hospital, The first college of Clinical Medical Science, China Three Gorges University Yichang China Department of Statistics University of Pittsburgh Pittsburgh Pennsylvania USA College of Bioscience and Biotechnology Hunan Agricultural University Changsha Hunan 410128 China Shenzhen Key Laboratory of Biomimetic Robotics and Intelligent Systems, Department of Mechanical and Energy Engineering, Southern University of Science and Technology, Shenzhen, China.; Guangdong Provincial Key Laboratory of Human-Augmentation and Rehabilitation Robotics in Universities, Southern University of Science and Technology, Shenzhen, China.; Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), Guangzhou, China. Department of Basic Medicine, Hangzhou Medical College, Hangzhou, Zhejiang 310053, P.R. China Xuzhou Central Hospital Affiliated to Nanjing University of Chinese Medicine, Xuzhou City, Jiangsu Province, 221009, China Health Science Center, Ningbo University, Ningbo 315211, China. Jiangsu Collaborative Innovation Center of Biomedical Functional Materials and Jiangsu Key Laboratory of Biofunctional Materials; School of Chemistry and Materials Science; Nanjing Normal University; Nanjing 210023; China School of Computer Science and Engineering, Nanyang Technological University, Singapore Guangdong Provincial Key Lab of Nano-Micro Material Research; School of Chemical Biology and Biotechnology; Peking University Shenzhen Graduate School; Shenzhen 518055; China Key Laboratory for Advanced Materials, Research Institute of Industrial Catalysis, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai 200237, PR China School of Environmental Science and Engineering, Shanghai Jiaotong University, Shanghai 200240, China Department of Biostatistics, Yale University, New Haven, Connecticut, USA Department of Respiratory Medicine Henan Provincial People's Hospital & the People's Hospital of Zhengzhou University Zhengzhou China CAS Key Laboratory of Bio-Medical Diagnostics, Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou 215163, Jiangsu, China; University of Chinese Academy of Sciences, Beijing 100049, China Department of General Surgery Comprehensive Breast Health Center Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China 1Department of Molecular Neuropathology, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China.; 2Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.; 3Chinese Glioma Genome Atlas Network, Beijing, China. Department of Hepatobiliary Surgery The Second Affiliated Hospital of Army Medical University No. 183 Xinqiao High Street 400037 Shapingba District, Chongqing China School of Pharmaceutical Science and Technology, Tianjin Key Laboratory for Modern Drug Delivery and High Efficiency, and Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin University, Tianjin 300072, China Center on Nanoenergy Research, School of Physical Science and Technology, Guangxi University, Nanning 530004, P. R. China Department of Molecular Neuropathology, Beijing Neurosurgical Institute, Capital Medical University Beijing 100050, China. Urology, The Fifth Affiliated Hospital of Xinjiang Medical University, Urumqi Xinjiang, China Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China *Department of Medicine, The University of Alabama at Birmingham, Birmingham, AL 35294; Center for Biomolecular Science and Engineering, US Naval Research Laboratory, Washington, DC 20375 USA University of Bath 1Liver Cancer Institute, Zhongshan Hospital, Fudan University; Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Fudan University, Shanghai, China. Center for Bio/Molecular Science and Engineering, U.S. Naval Research Laboratory, Washington, District of Columbia, USA Third Military Medical University, China National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China Beijing Neurosurgical Institute, Capital Medical University, Beijing, PR China; Beijing Institute for Brain Disorders, Brain Tumor Center, Beijing, PR China; Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, PR China Department of Pharmacology, Nanomedicine Engineering Laboratory of Jilin Province, College of Basic Medical Sciences, Jilin University, Changchun 130021, China Department of Cardiology The First Affiliated Hospital of Zhengzhou University Zhengzhou China School of Mechanical Engineering, Lanzhou Jiaotong University, Lanzhou 730070, China Department of Hepatobiliary Surgery, First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an 710061, Shaanxi, China Research division of the Linfen People's Hospital, Linfen, Shanxi, 041000, P. R. China. Department of Infectious Diseases, Renmin Hospital of Wuhan University, Wuhan, Hubei 430000, China From the State University of New York, State College of Optometry, Department of Biological Sciences, New York, New York; and the State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, P.R. China The High Pressure Research Center of Science and Technology, Zhengzhou University of Light Industry, Zhengzhou 450002, China Chongqing Key Laboratory of Inorganic Special Functional Materials, College of Chemistry and Chemical Engineering, Yangtze Normal University, Chongqing 408100, China Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China Department of Cell Biology, Shanghai Second Medical University, Shanghai, P. R. China 200025. Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Veterinary Medicine, China Agricultural University, Beijing, China Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA Department of Neurology, Wuhan Third Hospital (Tongren Hospital of Wuhan University), Wuhan, China State Key Laboratory of Microbial Metabolism, and School of Life Sciences & Biotechnology Shanghai Jiao Tong University Shanghai China School of Artificial Intelligence, Henan University, Zhengzhou, 450046, China. Electronic address: wangzheng@henu.edu.cn. National Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, the First Affiliated Hospital of Soochow University, Soochow University , Suzhou, P. R. China; Suzhou Jsuniwell Medical Laboratory , Suzhou, P. R. China Chair of Inorganic and Metal-Organic Chemistry, Department of Chemistry, Technical University of Munich, Lichtenbergtraße 4, Garching 85748, Germany Institute of Nanoscience and Nanotechnology School of Physical Science and Technology Lanzhou University Gansu 730000 China Department of Otorhinolaryngology The First Affiliated Hospital of China Medical University Shenyang Liaoning 110001 China Department of General Surgery, Northern Jiangsu Province Hospital, Clinical Medical College, Institute of General Surgery – Yangzhou, Yangzhou University, Yangzhou, P.R. China College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China Department of Chemistry & Chemical Biology, Rutgers The State University of New Jersey, 610 Taylor Road, Piscataway, New Jersey 08854 United States University of Toronto Department of Pathology, Beijing Hospital of the Ministry of Health, Beijing, China MOE Laboratory of Bioinorganic and Synthetic Chemistry; Lehn Institute of Functional Materials; School of Chemistry; Sun Yat-Sen University; Guangzhou Department of Orthopaedics, Chinese PLA General Hospital, Beijing, China State Key Laboratory of Plant Cell and Chromosome Engineering, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China Yale University, New Haven, CT, United States. Electronic address: Wang.Zheng@Yale.edu. 1State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, Fujian, China. Laboratory of Theoretical and Computational Chemistry and School of Chemistry and Chemical Engineering Yantai University Yantai 264005 China Department of Orthopedics, Zhenjiang Jinshan Hospital, Zhenjiang 212000, China Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, Jiangsu Key Laboratory of Biofunctional Materials, School of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, China; Beijing Key Laboratory for Source Control Technology of Water Pollution, College of Environmental Science and Engineering, Beijing Forestry University, Beijing 100083, China Department of Pathology, Beijing Hospital National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences Beijing China Department of Pathology, Beijing Hospital Beijing 100730, China. Department of Orthopedics of General Hospital of Northern Theater Command, Shenyang 110016, Liaoning Province, China Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts 02142; Center for Bio/Molecular Science and Engineering, Naval Research Laboratory, Washington, DC 20375 Shaanxi Key Laboratory of Chemical Additives for Industry College of Chemistry and Chemical Engineering Shaanxi University of Science and Technology Xi'an Shaanxi 710021 P. R. China Department of Physics, Zhengzhou University of Light Industry, Zhengzhou 450002, China, Laboratory of High Pressure Physics, Southwest Jiaotong University, Chengdu 610031, China, and State Key Laboratory of Superhard Materials, Jilin University, Changchun 130012, China Research Center for Tissue Engineering and Regenerative Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue 1277, Wuhan, China 430022; Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China 430022 Trinity Partners LLC, Waltham, MA, USA Department of Hepatobiliary Surgery The First Affiliated Hospital of Xi'an Jiaotong University Xi'an China Liver Surgery Department,Liver Cancer Institute, Zhongshan Hospital, Fudan University; Key Laboratory of Carcinogenesis and Cancer Invasion (Fudan University), Ministry of Education,Shanghai,China Research Center for Tissue Engineering and Regenerative Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China; Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, China Department of Hematology The First Affiliated Hospital of Soochow University Soochow China; SuZhou jsuniwell medical laboratory Suzhou China Department of Orthopedics, Chinese PLA General Hospital, Beijing 100853, China Department of General Surgery and Laboratory of General Surgery Xinhua Hospital, Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai China; Institute of Biliary Tract Disease, Shanghai Jiao Tong University School of Medicine Shanghai China CAS Key Laboratory of Bio‐Medical Diagnostics Suzhou Institute of Biomedical Engineering and Technology Chinese Academy of Sciences Suzhou China Department of General Surgery, Beijing Shijitan Hospital, Capital Medical University, Beijing, China Department of Respiratory Medicine Henan Provincial People's Hospital & The People's Hospital of Zhengzhou University Zhengzhou China Department of General Thoracic Surgery, The Second Clinical Medical College of Jinan University, Shenzhen People’s Hospital, Shenzhen, Guangdong Province College of Pharmacy, Third Military of Medical University, Chongqing 400038, PR China †Medicine, University of Alabama at Birmingham, Birmingham, AL 35294 Department of Ecology and Evolutionary Biology, Yale University, New Haven, Connecticut 06511 Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China. gzstwang@pub.guangzhou.gd.cn Institutes of Biology and Medical Sciences, Medical College, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou, China Department of Orthopedics, The General Hospital of Ningxia Medical University Yinchuan 750004, Ningxia Hui Autonomous Region, P. R. China. College of Mechanical & Electrical Engineering, Hohai University, Changzhou, Jiangsu 213022, China Institute of Life Sciences Jiangsu University 301 Xuefu Road Zhenjiang 212013 China Department of Occupational Therapy University of Florida Gainesville Florida USA; Department of Applied Physiology and Kinesiology University of Florida Gainesville Florida USA Wuxi Infectious Diseases Hospital, China Chinese People’s Liberation Army General Hospital, Haidian District, Beijing, China *Division of Clinical Immunology and Rheumatology, University of Alabama, Birmingham, AL 35294; Department of Mechanical Engineering, University of Alberta, Edmonton, AB T6G 2E1, Canada Institute of Respiratory Medicine, Affiliated Union Hospital of Huazhong University of Science and Technology, Wuhan, Hubei 430022, China. Department of Orthopedics, Chinese PLA General Hospital, Beijing, China Laboratory of Animal Microbiology and Immunology, State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, People's Republic of China Resident, Department of Orthodontics, West China Hospital of Stomatology, State Key Laboratory of Oral Diseases, Sichuan University, Chengdu, China. Department of Prosthodontics, School & Hospital of Stomatology, Tianjin Medical University, Tianjin 30070, China Department of Infectious Diseases, Renmin Hospital of Wuhan University, Wuhan 430060, China Department of Abdominal Surgical Oncology Cancer Hospital of the Chinese Academy of Medical Sciences Peking Union Medical College Beijing China Department of Stomatology, Tongren Hospital Shanghai Jiaotong University School of Medicine, Shanghai, China Cardiovascular Hospital,the First Affiliated Hospital of Zhengzhou University, Zhengzhou University,Zhengzhou,China Key Laboratory of Cluster Science of Ministry of Education; Beijing Key Laboratory of Photoelectronic/Electrophotonic; School of Chemistry and Chemical Engineering; Beijing Institute of Technology; Beijing 100081 State Key Laboratory of Analytical Chemistry for Life Science School of Chemistry and Chemical Engineering and Center of Materials Analysis Nanjing University Nanjing P. R. China The Key Laboratory of Carbohydrate Chemistry & Biotechnology Ministry of Education School of Biotechnology Jiangnan University Wuxi 214122 China College of Modern Information Technology, Zhejiang Institute of Mechanical Electrical Engineering, Hangzhou 310053, Zhejiang, China Comprehensive Breast Health Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China Research Initiative for Supra-Materials, Interdisciplinary Cluster for Cutting Edge Research; Shinshu University; Nagano 380-8553; Japan Institute of Nanoscience and Nanotechnology, School of Physical Science and Technology, Lanzhou University, Gansu 730000, China Department of Hepatobiliary Surgery,Eastern Hepatobiliary Surgery Hospital, Second Military Medical University,Shanghai,China; Department of Clinical Medicine,Second Military Medical University,Shanghai,China 2Clinical Immunology and Rheumatology, Hubei Key Laboratory of Regenerative Medicine and Multi‐disciplinary Translational Research Hubei Provincial Engineering Research Center of Clinical Laboratory and Active Health Smart Equipment Research Center for Tissue Engineering and Regenerative Medicine Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430022 China; Department of Gastrointestinal Surgery Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430022 China Department of Gastroenterology, Ningbo First Hospital, Ningbo; Medical School of Zhejiang University, Hangzhou, Zhejiang Province, China. Department of Critical Care, Affiliated Hospital of Gansu University of Chinese Medicine, Lanzhou 730000, Gansu, China. School of Pharmaceutical Science & Technology Tianjin Key Laboratory for Modern Drug Delivery & High Efficiency and Collaborative Innovation Center of Chemical Science and Engineering (Tianjin) Tianjin University Tianjin 300072 P. R. China; State Key Laboratory of Medicinal Chemical Biology Nankai University Tianjin 300071 P. R. China Center for Bio/Molecular Science and Engineering, U.S. Naval Research Laboratory, Washington, DC 20375, United States Department of Nephrology, the First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, China Department of Hepatobiliary Surgery, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, China First Department of Liver Disease,Beijing YouAn Hospital,Capital Medical University,Beijing,China Aier School of Ophthalmology, Central South University, Changsha; Department of Refractive Surgery, Guangzhou Aier Eye Hospital, Guangzhou; Aier Institute of Refractive Surgery, Aier Eye Hospital Group, Changsha, China. Department of Joints, Tianjin Hospital, Tianjin, China Liver Cancer Institute and Zhongshan Hospital, Key Laboratory of Carcinogenesis and Cancer Invasion; Fudan University, Ministry of Education; Shanghai People's Republic of China Department of Thoracic Surgery, The Second Clinical Medical College (Shenzhen People's Hospital), Jinan University, Shenzhen, Guangdong 518020, P.R. China Hospital of Stomatology, Guangdong Provincial Key Laboratory of Stomatology, Guanghua School of Stomatology, Institute of Stomatological Research, Sun Yat-sen University, Guangzhou, Guangdong Province, China Department of Hepatobiliary Surgery, Eastern Hepatobiliary Surgery Hospital; Department of Clinical Medicine, Second Military Medical University, Shanghai Authors' Affiliations: 1Department of Hepatobiliary Surgery, First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an, Shaanxi, China; and 2Department of Pharmaceutical Sciences, North Dakota State University, Fargo, North Dakota Department of Pharmacology University of Iowa Iowa City, Iowa 52242-1109 School of Communication, The Ohio State University, Columbus, OH 43210; and Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, School of Life Science Northwest University 229 Taibai Road Xi'an 710069 People's Republic of China Department of Genetics and Yale Stem Cell Center, Yale University, New Haven, CT, USA Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; Research Center for Tissue Engineering and Regenerative Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing China State Key Laboratory of Vegetable Biobreeding, Beijing Vegetable Research Center, Beijing Academy of Agriculture and Forestry Science, Beijing 100097, China; National Engineering Research Center for Vegetables, Beijing Vegetable Research Center, Beijing Academy of Agriculture and Forestry Science, Beijing 100097, China; Beijing Key Laboratory of Vegetable Germplasms Improvement, Beijing 100097, China; Key Laboratory of Biology and Genetics Improvement of Horticultural Crops (North China), Beijing 100097, China Department of Radiation Oncology, Shanghai Proton and Heavy Ion Center , Shanghai , China; Shanghai Key Laboratory of Radiation Oncology (20dz2261000) , Shanghai , China; Shanghai Engineering Research Center of Proton and Heavy Ion Radiation Therapy , Shanghai , China; Department of Radiation Oncology, Shanghai Proton and Heavy Ion Center, Fudan University Cancer Hospital , Shanghai , China Department of Respiratory Medicine; Henan Provincial People's Hospital & the People's Hospital of Zhengzhou University; Zhengzhou China Department of Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, New York, United States The University of Texas at Austin 1 Department of Electrical and Computer Engineering, Microelectronics Research Center, , 10100 Burnet Rd., Austin, Texas 78758, USA; The University of Texas at Austin 3 Materials Science and Engineering Program, Texas Materials Institute, , Austin, Texas 78712, USA Department of Infectious Diseases, Qilu Hospital, Shandong University, Jinan, Shandong, China (mainland) State Key Laboratory of Plant Cell and Chromosome Engineering Institute of Genetics and Developmental Biology The Innovative Academy of Seed Design Chinese Academy of Sciences Beijing China Department of Psychology, Vanderbilt University, Nashville, 37211 TN, USA Department of Pathology, University of Virginia Health Sciences Center, Charlottesville, VA 22908; Department of Pediatrics and Physiology and Biophysics, Georgetown University Medical Center, Washington, DC 20007; Department of Microbiology, Meharry Medical College, Nashville, TN 37208; Department of Medicine and Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232; Department of Pathology, Medical University of South Carolina, Charleston, SC 29403; Institute for Molecular and... a School of Municipal and Environmental Engineering , Harbin Institute of Technology , Harbin , China State Key Laboratory of Drug Research; Shanghai Institute of Materia Medica; Chinese Academy of Sciences; Shanghai 201203; China Department of General Surgery Huashan Hospital and Cancer Metastasis Institute and Institutes of Biomedical Sciences, Fudan University Shanghai China National Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, the First Affiliated Hospital of Soochow University, Soochow University, Suzhou, People’s Republic of China; Suzhou jsuniwell medical laboratory, Suzhou, People’s Republic of China Laboratory of Cellular and Molecular Tumor Immunology Jiangsu Key Laboratory of Infection and Immunity Institutes of Biology and Medical Sciences Soochow University Suzhou China School of Chemical and Biomedical Engineering, Nanyang Technological University, 62 Nanyang Drive, 637459 Singapore Department of Genetics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461 Department of Radiology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430014, P.R. China The Core Laboratory in Medical Center of Clinical Research, State Key Laboratory of Medical Genomics, Department of Molecular Diagnostics & Endocrinology, Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai China Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, Key Laboratory of Carcinogenesis and Cancer Invasion, Fudan University, Ministry of Education, Shanghai, China Department of Kinesiology, The Pennsylvania State University, 23 Rec Building, University Park, PA 16802, USA. zxw117@psu.edu Department of Orthopedics, 455th Hospital of PLA, Shanghai 200052, P.R. China Beijing Neurosurgical Institute, Capital Medical University, Beijing, PR China Beijing Neurosurgical Institute, Capital Medical University, Beijing 100050, PR China Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Fudan University, Shanghai, China (mainland) Department of Radiation Oncology Shanghai Proton and Heavy Ion Center Shanghai China; Shanghai Key Laboratory of Radiation Oncology (20dz2261000) Shanghai China; Shanghai Engineering Research Center of Proton and Heavy Ion Radiation Therapy Shanghai China; Department of Radiation Oncology Shanghai Proton and Heavy Ion Center, Fudan University Cancer Hospital Shanghai China College of Pharmacy, Woosuk University Department of Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China Department of General Surgery, Huashan Hospital, Fudan University, Shanghai, China.; Institutes of Cancer Metastasis, Fudan University, Shanghai, China. Department of Gastrointestinal Surgery, Cancer Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China. Hebei Key Laboratory of Integrative Medicine on Liver-Kidney Patterns, Hebei University of Chinese Medicine, Shijiazhuang, China; Department of Internal Medicine, Hebei University of Chinese Medicine, Shijiazhuang, China School of Educational Science, Huazhong University of Science and Technology, Wuhan, China Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, No. 1 Jianshe East Road, Zhengzhou 450052, Henan, China Science and Technology on Electronic Test and Measurement Laboratory, North University of China, Taiyuan 030051, China Department of Biological Sciences, SUNY State College of Optometry, New York, NY, USA. Department of Pharmacology, Xi’an Jiaotong University School of Basic Medical Sciences Department of Orthopedics No. 1 Medical Center of Chinese PLA General Hospital Beijing China State Key Laboratory of Natural Medicines Department of Pharmaceutics China Pharmaceutical University Nanjing 210009 P. R. China Innovation Center China AstraZeneca Global R&D China College of Biology and the Environment, Nanjing Forestry University, Nanjing, Jiangsu, China Department of Pharmacology, School of Medicine, Xi’an Jiaotong University, Xi’an, China; Department of Pharmacy, the First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, China Department of HIV/AIDS Research, State Key Laboratory of Pathogen and Biosecurity, Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing 100071, China. Department of Spine Surgery, The Third Hospital of Hebei Medical University, 139 Ziqiang Road, Shijiazhuang 050051, China Department of Orthopedics Trauma and Microsurgery, Zhongnan Hospital of Wuhan University, Wuhan 430000, China Ultra-Precision Optoelectronic Instrument Engineering Center, School of Instrument Science and Engineering, Harbin Institute of Technology, Harbin 150080, China; Key Laboratory of Ultra-Precision Intelligent Instrumentation, Harbin Institute of Technology, Ministry of Industry and Information Technology, Harbin 150080, China State Key Laboratory of Loess and Quaternary Geology Institute of Earth Environment, Chinese Academy of Sciences Xi'an China; CAS Center for Excellence in Quaternary Science and Global Change Xi'an China Department of Physics, Massachusetts Institute of Technology, Cambridge, MA 02139; and; Department of Electrical and Computer Engineering, University of Texas at Austin, Austin, TX 78712-0240 Mental Health Institute of the Second Xiangya Hospital, Central South University, Changsha, PR China Department of Orthopedics, General Hospital of People's Liberation Army, 28 Fuxing Road, Beijing 100853, People's Republic of China State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China. gzstwang@pub.guangzhou.gd.cn From the Department of Biological Sciences, College of Optometry, State University of New York, New York, New York; the Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama; College of Pharmacy and Shaanxi Qinling Application Development and Engineering Center of Chinese Herbal Medicine, Shaanxi University of Chinese Medicine, Shaanxi University of Chinese Medicine, Xianyang, China.; Shaanxi Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, State Key Laboratory of Research & Development of Characteristic Qin Medicine Resources (Cultivation), Shaanxi Innovative Drug Research Center, Shaanxi University of Chinese Medicine, Xianyang, China. State Key Laboratory of Silicate Materials for Architectures, Wuhan University of Technology, Wuhan 430070, China; Shenzhen Research Institute of Wuhan University of Technology, Shenzhen 518000, China Department of Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, NY. Department of Orthopedics Trauma and Microsurgery, Zhongnan Hospital of Wuhan University, Wuhan 430071, China; Hubei Clinical Medical Research Center of Trauma and Microsurgery, Wuhan, Hubei 430071, China CAS Key Laboratory of Biomedical Diagnostics, Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Science (CAS), 88 Keling Road, Suzhou 215163, People’s Republic of China Department of Trauma Orthopaedics The General Hospital of Ningxia Medical University Yinchuan China Institute of Forensic Medicine, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University , Chengdu , China Department of Pediatrics, Second Hospital of West China, Sichuan University, Chengdu, China, The Spine Surgery The First Medical Center of the Chinese PLA General Hospital Beijing China Department of Hepatobiliary Surgery The First Affiliated Hospital of Xi'an Jiaotong University Xi'an China; Department of Surgical Intensive Care Unit The First Affiliated Hospital of Xi'an Jiaotong University Xi'an China; Pancreatic Disease Center of Xi'an Jiaotong University Xi'an China Department of Orthopedics Chinese PLA General Hospital Beijing, 100853 China College of Chemistry and Environmental Engineering Sichuan University of Science and Engineering Zigong Sichuan 643000 China Chemical Research and Development, Pfizer Inc., Groton, Connecticut06340, United States Hunan Provincial Engineering Research Center for Ginkgo biloba; Hunan University of Science and Engineering; Yongzhou 425100; China State Key Lab of Loess and Quaternary Geology IEE, CAS Xi'an 710075 China Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China Department of Respiratory and Critical Care Medicine, The Second Hospital of Hebei Medical University, Shijiazhuang, China Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University , Xi'an 70061 , China; Pancreatic disease treatment center, Xi'an Jiaotong University , Xi'an 70061 , China Hunan University † Department of Radiology, Washington University School of Medicine, St. Louis, MO 63110 Department of Obstetrics and Gynecology, Affiliated Hospital, Logistical College of Chinese People’s Armed Police Forces, Tianjin, PR China; Department of Liver Surgery, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Key Laboratory of Carcinogenesis and Cancer Invasion, Fudan University, Ministry of Education, Shanghai 200032, P.R. China Department of Forensic Genetics West China School of Preclinical and Forensic Medicine Sichuan University (West China University of Medical Sciences) Chengdu 610041 China Department of Urology The First Affiliated Hospital of Harbin Medical University Harbin China Guilin Sanjin Pharmaceutical Company Limited, Guilin 541004, China. Institute of Forensic Medicine, West China School of Basic Medical Science and Forensic Medicine, Sichuan University, Chengdu, China School of Medicine Jiaxing University Jiaxing China Informatics and Technology Astra Zeneca China Shanghai China Division of Vascular Surgery Department of Surgery Feinberg School of Medicine Northwestern University 251 East Huron St. Galter 3–150 Chicago IL 60611 USA; Simpson Querrey Institute Northwestern University 303 E. Superior, Suite 11–131 Chicago IL 60611 USA School of Environmental Science and Engineering, Shanghai Jiaotong University, Shanghai, People’s Republic of China Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, Beijing 101400, China Center for Tissue Engineering and Regenerative Medicine, Union Hospital, Wuhan, China; Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Department of Gastrointestinal Surgery, Union Hospital, Wuhan, China; Development and Molecular Oncology Laboratory, Union Hospital, Wuhan, China Section of Molecular Genetics and Microbiology, School of Biological Sciences, The University of Texas at Austin, Austin, Texas 78712 School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China, School of Chemistry, University of Birmingham, Edgbaston, Birmingham B15 2TT, U.K., and College of Chemical Engineering and Materials Science, Zhejiang University of Technology, Hangzhou 310014, China School of Computing, University of Southern Mississippi, Hattiesburg, MS, USA Department of Pathology, Tongji Medical College, 13 Hangkong Road, Wuhan 430030, Hubei province, China. Guangdong Key Laboratory of Electric Power Equipment Reliability, Electric Power Research Institute of Guangdong Power Grid Co., Ltd., Guangzhou 510080, China Institute of Neuroscience, State Key Laboratory of Neuroscience, Chinese Academy of Sciences Center for Excellence in Brain Science and Intelligence Technology, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, Shanghai, China Department of Cardiology, Heilongjiang Provincial Hospital, Harbin, China. School of Communication The Ohio State University Department of Radiology Beijing Friendship Hospital Capital Medical University Beijing China Zhongshan Ophthalmic Center of Sun Yat-sen University, the State Key Laboratory of Ophthalmology, Guangzhou 510060, Guangdong Province, China. Research Center for Tissue Engineering and Regenerative Medicine, Union Hospital, Tongji Medical College, §Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, ⊥Medical Research Center, Union Hospital, Tongji Medical College, ∥Department of Clinical Laboratory, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China Department of Electrical and Computer Engineering, Clemson University , South Carolina 29634, USA Department of Nephrology, West China Hospital Sichuan University Chengdu China State Key Laboratory of Organometallic Chemistry, Center of Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, P. R. China Department of Biostatistics. Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, Piscataway, NJ 08854; and The General Hospital of Chinese People's Liberation Army (301 Hospital) Department of Pharmaceutical Microbiology, School of Life Science and Technology China Pharmaceutical University Nanjing China National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China 2 National Institute of Biological Sciences, 102206 Beijing, China;; Graduate School of Peking Union Medical College, 100730 Beijing, China; Department of Hepatobiliary Surgery, Third Xiangya Hospital, Central South University, Changsha 410013, China. Department of Pathology, The Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, Jiangsu 225009, P.R. China Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Department of Chemistry & Chemical Biology, Rutgers The State University of New Jersey, 610 Taylor Road, Piscataway, New Jersey 08854, United States Faculty of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Kumamoto 862, Japan Department of Hepatobiliary Surgery, First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, China College of Kinesiology, Shenyang Sport University, Shen-yang, China Department of Computer Science, University of Miami , Coral Gables, FL, USA Department of Cardiology; The First Affiliated Hospital of Zhengzhou University; Zhengzhou 450052; China Department of Respiratory and Critical Care Medicine, the People's Hospital of Zhengzhou University, Zhengzhou 450003, China. Tianjin Key Laboratory of Protein Science, College of Life Science, Nankai University Tianjin China College of Veterinary Medicine, Northwest A&F University, Key Laboratory of Animal Biotechnology of the Ministry of Agriculture, Yangling 712100, Shaanxi Province, China Department of Psychology, Vanderbilt University, Nashville, Tennessee, USA State Key Laboratory of Organometallic Chemistry Center for Excellence in Molecular Synthesis Shanghai Institute of Organic Chemistry Chinese Academy of Sciences 345 Lingling Road Shanghai 200032 China School of Materials and Energy, Lanzhou University, Lanzhou 730000, China State Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic and Developmental Sciences, School of Life Sciences and Biotechnology Shanghai Jiao Tong University Shanghai 200240 China Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan China Department of Obstetrics and Gynaecology, University Medical Centre Groningen, Groningen, The Netherlands. University of Texas Health Sciences Center, Houston, TX CAS Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences,University of Chinese Academy of Sciences, Chinese Academy of Sciences,Shanghai,China Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China; Chinese Glioma Genome Atlas network, Beijing, China Institute of Molecular Medicine, The University of Texas Health Science Center, Houston, TX 77030, USA. Department of Pediatrics, West China Second University Hospital of Sichuan University, Chengdu - China Department of Physics, NanChang University; Nanchang 330031; P. R. China Department of Thoracic Surgery, Shenzhen People’s Hospital, Second Clinical Medical College of Jinan University, Shenzhen, 518020 Guangdong, China Department of Vascular Surgery, The Third Xiangya Hospital, Central South University, Changsha, Hunan Province, P. R. China Beijing Hospital, Beijing 100730, China. Department of Oncology, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, China; Department of Medical Oncology, Xi'an Central Hospital, Xi'an 710004, China Authors' Affiliations: 1Liver Cancer Institute; 2Shanghai Key Laboratory of Organ Transplantation; 3Department of Pathology, Zhong Shan Hospital, Fudan University; and 4Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China School of Pharmaceutical Science and Technology Tianjin Key Laboratory for Modern Drug Delivery and High Efficiency and Collaborative Innovation Center of Chemical Science and Engineering (Tianjin) Tianjin University Tianjin 300072 China QiLu Aerospace Information Research Institute, Jinan 250101, China Department of Hepatobiliary Surgery, Xi'an Jiaotong University, 277 West Yanta Road, Xi'an 710061, China Department of Chemistry, Energy Institute and Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, Hong Kong University of Science and Technology, Clear Water Bay Kowloon, Hong Kong Shaanxi Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Shaanxi University of Chinese Medicine, Xian Yang, China. 1 Department of Thoracic Surgery, 2 Department of Pathology, Peking University First Hospital, Beijing 100034, China. Department of Computer Science, University of Miami , 1365 Memorial Drive, 33124, FL , USA Institute of Urban Agriculture, Chinese Academy of Agricultural Sciences (IUA-CAAS), Chengdu National Agricultural Science and Technology Center, Chengdu 610213, China Department of Medical Microbiology and Parasitology, Shanghai Jiao Tong University School of Medicine, Shanghai, China State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Road, Shanghai 200032, China MOE Laboratory of Bioinorganic and Synthetic Chemistry, Lehn Institute of Functional Materials, School of Chemistry, Sun Yat-Sen University, Guangzhou, Guangdong 510275, China Department of Molecular Neuropathology Beijing Neurosurgical Institute, Capital Medical University Beijing China; Chinese Glioma Cooperative Group (CGCG) China Department of Information Science and Technology, Nanjing Forest Police College, Nanjing, China; Department of Thyroid Surgery The First Affiliated Hospital of Zhengzhou University Zhengzhou Henan China; Department of Breast and Thyroid Surgery Nanyang Central Hospital Nanyang China Ciphergen Biosystems, 6611 Dumbarton Circle, Fremont, CA 94555 Postgraduate Class of Hubei College of TCM, Wuhan 430061, China. fayewong_520@tom.com Department of Biostatistics, Yale School of Public Health, New Haven, Connecticut, USA Water Pollution Control Research Centre, Harbin Institute of Technology, Harbin 150090, China. mezwang@163.com Department of Medical Microbiology and Parasitology, Institutes of Medical Sciences, Shanghai Jiao Tong University School of Medicine, Shanghai, China Department of Chemical and Environmental Engineering, Faculty of Science and Engineering, University of Nottingham, Ningbo 315100, PR China Key Laboratory of Fluorine and Nitrogen Chemistry and Advanced Materials, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 345 Lingling Road, 200032 Shanghai, China Department of Emergency, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325027, P.R. China Department of Hematology, The First Affiliated Hospital of Soochow University, Soochow, People’s Republic of China; SuZhou Jsuniwell Medical Laboratory, Suzhou, People’s Republic of China Key Laboratory of Functional Materials and Devices for Special Environments, Xinjiang Technical Institute of Physics & Chemistry, Chinese Academy of Sciences; Xinjiang Key Laboratory of Electronic Information Materials and Devices, 40-1 South Beijing Road, Urumqi 830011, China Department of Cardiology, Heilongjiang Provincial Hospital, Harbin, Heilongjiang, People’s Republic of China School of Physical Science and Technology, Key Laboratory for Magnetism and Magnetic Materials of the Ministry of Education, Lanzhou University, Lanzhou 730000, P. R. China Department of Abdominal Surgical Oncology, Cancer Hospital (Institute), Chinese Academy of Medical Sciences, Beijing 100021, China. Cancer Institute and Hospital, Chinese Academy of Medical Sciences (CAMS),Beijing, People's Republic of China Research Initiative for Supra-Materials, Interdisciplinary Cluster for Cutting Edge Research, Shinshu University, 4-17-1 Wakasato, Nagano-shi, Nagano 380-8553, Japan Department of Pharmacy, Beijing Friendship Hospital, Capital Medical University, Beijing, China. Department of Physical Medicine and Rehabilitation, The No. 2 Hospital of Baoding, Baoding, PR China; Department of CT Scan, The No. 2 Hospital of Baoding, Baoding, PR China University of Groningen, University Medical Centre Groningen, Department of Obstetrics and Gynecology, Groningen, The Netherlands. Department of Pathology, Affiliated Hospital of Yangzhou University, Yangzhou 225001, China Department of Blood Transfusion, Sir Run Run Hospital, Nanjing Medical University, Nanjing, P.R. China. School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798, Singapore Department of Medicine, Division of Pulmonary, Allergy and Critical Care, University of Alabama at Birmingham, Birmingham, Alabama; Department of Neurosurgery, Beijing Tiantan Hospital Capital Medical University Beijing China Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, P.R. China. Department of Critical Care Medicine, People’s Hospital of Maoming, Maoming, Guangdong, China. Department of Cardiothoracic Surgery and Abdominal Hernia Surgery, The People's Hospital of Kai Zhou District, Chongqing 405400, P.R. China School of Mechanical and Electrical Engineering, Shandong Jianzhu University, Jinan 250101, China Department of Nephrology, Nephrology Hospital of The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China; Institute of Nephrology, Zhengzhou University Institute of Nephrology, Zhengzhou, China Cardiovascular Division Faculty of Medicine University of Tsukuba Tsukuba Japan Department of Thoracic Surgery, Shenzhen People's Hospital, Shenzhen, People's Republic of China. Department of Vascular Surgery, Renji Hospital, Shanghai Second Medical University, Shanghai 200001, China. 1Department of Medicine, Stanford University, Division of Sports Medicine and Adult Reconstructive Surgery Department of Orthopedic Surgery Nanjing Drum Tower Hospital Affiliated Hospital of Medical School Nanjing University 321 Zhongshan Road Nanjing Jiangsu 210008 China Department of General Surgery Beijing Shijitan Hospital, Capital Medical University Beijing China State Key Laboratory of High-efficiency Utilization of Coal and Green Chemical Engineering; College of Chemistry and Chemical Engineering; Ningxia University; Yinchuan 750021; China Department of Orthopaedics The General Hospital of Chinese PLA Beijing China Department of Endocrinology, Affiliated Zhongda Hospital of Southeast University, Nanjing 210000, Jiangsu Province, China; School of Medicine, Southeast University, Nanjing 210000, Jiangsu Province, China Department of Joints, Tianjin Hospital, Tianjin University, 300211, China; Clinical College of Orthopedics, Tianjin Medical University, Tianjin 300211, China Departments of 1Hepatobiliary Surgery, Department of General Surgery Huashan Hospital Fudan University Shanghai China; Cancer Metastasis Institute Fudan University Shanghai China Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai 200032, China Department of Hepatobiliary Surgery, The First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China Hainan Provincial Key Laboratory of Genetic Improvement and Quality Regulation for Tropical Spice and Beverage Crops, Spice and Beverage Research Institute, Chinese Academy of Tropical Agricultural Sciences, Wanning, China Department of Clinical Laboratory Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430022 China; Department of Gastrointestinal Surgery Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430022 China College of Pharmacy, Woosuk University, Wanju 55338, Korea. Institute of Neuroscience, Center for Excellence in Brain Science and Intelligence Technology, State Key Laboratory of Neuroscience, Key Laboratory of Primate Neurobiology, Chinese Academy of Sciences, Shanghai (Zhan, Wang); University of Chinese Academy of Sciences, Beijing (Zhan, Wang); School of Artificial Intelligence, University of Chinese Academy of Sciences, Beijing (Wei); Institute of Automation, Center for Excellence in Brain Science and Intelligence Technology, National Laboratory of Pattern... Department of Hepatobiliary Surgery, The First Affiliated Hospital, Medical College of Xi'an Jiaotong University, Xi'an 710061, Shaanxi, P.R. China. qyma56@mail.xjtu.edu.cn or xjxpx@189.cn. Beijing YouAn Hospital, Capital Medical University, Beijing, China Trinity Life Sciences, Waltham, Massachusetts Department of Chemistry, School of Chemistry and Materials Science University of Science and Technology of China (USTC) Hefei 230026 China Department of Pharmacy, Zhongshan Hospital Affiliated to Xiamen University, Xiamen, China CAS Key Laboratory of Nano-Bio Interface, Suzhou Institute of Nano-Tech and NanoBionics, Chinese Academy of Sciences, Suzhou 215123, China. Center for Bio/Molecular Science and Engineering, US Naval Research Laboratory, Washington, D.C. 20375, United States of America HCW Biologics Inc. Miramar Florida USA Anhui Key Laboratory of Modern Chinese Materia Medica, School of Pharmacy, Anhui University of Chinese Medicine, Hefei, China Department of Respiratory and Critical Medicine People's Hospital of Zhengzhou University China College of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 610000, China Center for Bio/Molecular Science & Engineering, US Naval Research Laboratory, Washington, D.C. 20375, United States Department of Orthopedic Spinal Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Peking University People's Hospital, Beijing 100044, China. laiyueyun1008@sina.com. Biomime, 909 E. Sunnycrest Drive, Urbana, Illinois 61801, U.S.A., and School of Materials Science and Engineering, Nanyang Avenue, Nanyang Technological University, Singapore 639798 State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, Fujian, China; State-Province Joint Engineering Laboratory of Targeted Drugs from Natural Products, Xiamen University, Xiamen, Fujian, China State Key Laboratory of Organometallic Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China Hunan Provincial Engineering Research Center for Ginkgobiloba, Hunan University of Science and Engineering Department of Pathology, the First Affiliated Hospital of Nanjing Medical University,Nanjing 210029, China. Department of Chemistry The Hong Kong University of Science and Technology Clear Water Bay, Kowloon Hong Kong Hong Kong Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei China Department of Inorganic and Analytical Chemistry; University of Geneva; CH-1211 Geneva 4; Switzerland College of Integrative Medicine, Hebei University of Chinese Medicine, Shijiazhuang, China; Institute of Integrative Medicine, Hebei University of Chinese Medicine, Shijiazhuang, China; Hebei Key Laboratory of Integrative Medicine on Liver-Kidney Patterns, Hebei University of Chinese Medicine, Shijiazhuang, China State Key Laboratory of Heavy Oil Processing and the Centre for Bioengineering and Biotechnology, China University of Petroleum (East China), 66 Changjiang West Road, Qingdao 266580, China Department of Medical Biophysics, The University of Western Ontario, London, Ontario, Canada; Centre for Functional and Metabolic Mapping, Robarts Research Institute, London, Ontario, Canada Molecular and Cell Biology Laboratory, Salk Institute for Biological Studies, La Jolla, United States Department of Metallurgy; Beijing General Research Institute of Mining and Metallurgy; Beijing 100070; P. R. China School of Chemistry, Tiangong University, Tianjin 300387, P. R. China Guangzhou Aier Eye Hospital, Guangdong, China; Department of Surgery, Tianjin Medical University General Hospital, Tianjin 300052, P.R. China School of Electrical and Power Engineering, China University of Mining and Technology, Xuzhou 221116, PR China Department of Gastrointestinal Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University Shanghai China Institute of Industrial Science, The University of Tokyo, Tokyo, Japan College of Biology and the Environment, Nanjing Forestry University, Nanjing, Jiangsu, China, State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China Shanghai Key Laboratory of Clinical Geriatric Medicine, Shanghai, China; Department of Geriatrics, Huadong Hospital Affiliated to Fudan University, Shanghai, China Purple Mountain Observatory, CAS 1 , Nanjing 210033, China Department of Thoracic Surgery, Ningbo Medical Center Lihuili Hospital, Ningbo University, Ningbo, Zhejiang 315040, China Department of Computer Science, University of California, Los Angeles, CA 90095, USA Department of Medicine, Division of Infectious Diseases, Columbia University Medical Center, New York, New York, USA Institute of Forensic Medicine, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu, China Department of Chemistry The Hong Kong University of Science and Technology Clear Water Bay Kowloon Hong Kong P.R. China Medical Center of Hematology the Second Affiliated Hospital Army Medical University Chongqing China; State Key Laboratory of Trauma Burn and Combined Injury Army Medical University Chongqing China Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials, Ministry-of-Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules & College of Chemistry & Chemical Engineering, Hubei University, Wuhan, 430062, P. R. China School of Pharmacy, Second Military Medical University, Shanghai, China Department of General Surgery, Comprehensive Breast Health Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin Er Road, Shanghai 200025, China College of Material Science and Engineering, Taiyuan University of Technology, Taiyuan, People’s Republic of China Key Laboratory of Engineering Plastics and Beijing National Laboratory for Molecular Science; Institute of Chemistry; Chinese Academy of Sciences; Beijing 100190; China Beijing Neurosurgical Institute, Capital Medical University, Beijing, China; Chinese Glioma Genome Atlas Network (CGGA) Department of Mechanical and Energy Engineering, Southern University of Science and Technology, Shenzhen, China. Department of Ophthalmology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing 100730, China Center for Bio/Molecular Science and Engineering, Naval Research Laboratory, Washington, DC 20375 College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University , Daqing , , China Department of Computer Science, University of Miami, 1365 Memorial Drive, P.O. Box 248154, Coral Gables, FL 33124, USA State Key Laboratory of Organometallic Chemistry Center for Excellence in Molecular Synthesis Shanghai Institute of Organic Chemistry University of Chinese Academy of Sciences Chinese Academy of Sciences 345 Lingling Road Shanghai 200032 China Key Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province, School of Medicine, Hangzhou City University, Hangzhou 310015, People’s Republic of China; College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, People’s Republic of China College of Forestry, Hebei Agricultural University, Baoding, China; Hebei Urban Forest Health Technology Innovation Center, Baoding, China Department of Respiratory and Critical Medicine, People's Hospital of Zhengzhou University, Zhengzhou, Henan 450003, P.R. China School of Pharmaceutical Science & Technology; Tianjin Key Laboratory for Modern Drug Delivery & High Efficiency; and Collaborative Innovation Center of Chemical Science and Engineering (Tianjin); Tianjin University; Tianjin 300072 1Research Center for Tissue Engineering and Regenerative Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.; 8Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. Department of Computer Science, University of Miami, Coral Gables, FL, USA State Key Laboratory of Plant Cell and Chromosome Engineering Institute of Genetics and Developmental Biology Chinese Academy of Sciences Beijing China †Division of Clinical Immunology and Rheumatology, University of Alabama, Birmingham, AL 35294 *Section of Oral Biology and Department of Pediatrics, West China Second University Hospital of Sichuan University Department of Biology Research, Ciphergen Biosystems Inc. School of Materials and Energy, Lanzhou University, Lanzhou 730000, P. R. China Department of Hand and Foot Surgery, Changyi People's Hospital, Changyi, Shandong 261300, P.R. China Shaanxi Engineering Research Center of Oil and Gas Resource Optical Fiber Detection, Shaanxi Key Laboratory of Measurement and Control Technology for Oil and Gas Wells, Xi’an Shiyou University, Xi’an 710065, China; State Key Laboratory of Solidification Processing, Center of Advanced Lubrication and Seal Materials, School of Materials Science and Engineering, Northwestern Polytechnical University, Xi’an, Shanxi 710072, China Research Initiative for Supra-Materials (RISM) Shinshu University 4-17-1 Wakasato Nagano 380-8553 Japan †Herman B Wells Pediatric Research Center, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202; College of Veterinary Medicine, Northwest A & F University, Yangling, Shaanxi, P.R. China; Key Laboratory of Animal Biotechnology, Ministry of Agriculture and Rural Affairs, Northwest A&F University, Yangling, P.R. China State Key Laboratory of Loess and Quaternary Geology, Institute of Earth Environment (IEE), Chinese Academy of Sciences (CAS), Xi’an 710075, People’s Republic of China Ultra-Precision Optoelectronic Instrument Engineering Center, School of Instrument Science and Engineering, Harbin Institute of Technology, Harbin 150080, China School of Pharmaceutical Science & Technology Tianjin Key Laboratory for Modern Drug Delivery & High Efficiency Collaborative Innovation Center of Chemical Science and Engineering (Tianjin) Tianjin University Tianjin 300072 P. R. China School of Pharmaceutical Science; Jiangnan University; Wuxi; China Hainan Province Nongken Sanya Hospital, China Department of Pharmaceutical Microbiology, School of Life Science and Technology, China Pharmaceutical University , Nanjing, China Department of Ophthalmology Beijing Hospital Beijing China Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Health Science Center, Xi'an, Shaanxi 710061, P.R. China Department of Chemistry, Rutgers University, Piscataway, New Jersey 08855-0939 Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Jiaotong University, Xi’an, China Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, Shaanxi, China Institute of Neurology Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China; State Key Laboratory of Medical Neurobiology Department of Neurology Huashan Hospital Fudan University Shanghai China State Key Laboratory of Oral Diseases National Clinical Research Center for Oral Diseases Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, Med‐X Center for Materials West China Hospital of Stomatology Sichuan University Chengdu Sichuan 610041 P. R. China From the Departments of Pediatrics (S.Z., P.Y., C.Z., Z.W., Z.Y., P.A.J.), Physiology and Biophysics (Z.Y., P.A.J.), and Cell Biology (P.M.A.), Georgetown University Medical Center, Washington, DC, and the Department of Pathology, The University of Virginia Health Sciences Center (R.A.F.), Charlottesville, Va. Department of HIV/AIDS Research, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China. Zhong Dian Animal Disease Control Center Shangri‐La Yunnan China Key Laboratory of Cluster Science of Ministry of Education, Beijing Key Laboratory of Photoelectronic/Electrophotonic, School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing 100081, People’s Republic of China Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China. wangzheng@mail.sic.ac.cn Department of Molecular and Cellular Physiology, Albany Medical College, Albany, New York Department of Gastroenterology, Shijiazhuang People's Hospital Shijiazhuang, Hebei, P. R. China. State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic Chemistry Chinese Academy of Sciences 345 Lingling Road Shanghai 200032 P.R. China Department of Hepatobiliary Surgery First Affiliated Hospital Xi’an Jiaotong University Xi’an China Department of Neurology, Huashan hospital State Key Laboratory of Medical Neurobiology, Fudan University Shanghai China Shenzhen People's Hospital, 518020 Shenzhen, China. Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China; Department of Molecular Neuropathology, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China Department of Colorectal Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China The department of Pediatrics, West China Second University Hospital of Sichuan University, Chengdu 610041, Sichuan, China; Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu 610041, Sichuan, China. The General Hospital of Chinese People's Liberation Army (301 hospital) Beijing, China. Nanjing University Department of Pathology Cancer Hospital of China Medical University & Liaoning Cancer Hospital and Institute Shenyang China Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205; Cardiovascular Hospital,the First Affiliated Hospital of Zhengzhou University,Zhengzhou University,Zhengzhou,China Department of Chemistry; The Hong Kong University of Science and Technology; Kowloon; P. R. China Department of Biological Sciences, State University of New York-Optometry, New York, New York 10010 Department of Biochemistry, Zhongshan Medical School, Sun Yat-sen University, Guangzhou, Guangdong Province, China; The University of Texas Health Science Center at Houston State Key Laboratory of Plant Physiology and Biochemistry College of Biological Sciences China Agricultural University Beijing 100193 China The People's Hospital of Zhengzhou University 450003 Zhengzhou China 1Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland; Department of Cardiothoracic Surgery Central Theater Command General Hospital of Chinese People's Liberation Army Wuhan China Department of Psychiatry, First Affiliated Hospital, Zhejiang University School of Medicine; The Key Laboratory of Mental Disorder's Management of Zhejiang Province, No. 79, Qingchun Road; Brain Research Institute of Zhejiang University, Hangzhou, China. Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, School of Physics; Key Laboratory of Functional Polymer Materials of Ministry of Education; Nankai University, and Collaborative Innovation Center of Chemical Science and Engineering (Tianjin); Tianjin; China CAS Key Laboratory of Bio‐Medical Diagnostics Suzhou Institute of Biomedical Engineering and Technology Chinese Academy of Sciences Suzhou China; University of Chinese Academy of Sciences Beijing China School of Communication and Information Engineering; Shanghai University; Shanghai 200444; China; CAS Key Laboratory of Bio-Medical Diagnostics School of Physics, Key Laboratory of Functional Polymer Materials of Ministry of Education, Nankai University, Tianjin 300071, China Department of Mechanical Engineering and The University of Hong Kong, Hong Kong, China. Department of Oncology, The Central Hospital of Xi’an, Xi’an 710003, China Department of Orthopaedics, Chines People’s Liberation Army General Hospital, Beijing Department of Pathology, Beijing Hospital, National Center of Gerontology Institute of Geriatric Medicine, Chinese Academy of Medical Science Beijing People’s Republic of China Department of General Surgery Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai China; Shanghai Key Laboratory of Biliary Tract Disease Research Shanghai China; Shanghai Research Center of Biliary Tract Disease Shanghai China State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences 345 Lingling Road Shanghai 200032 China State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, P. R. China Department of Endocrinology The Affiliated ZhongDa Hospital of Southeast University Nanjing China; School of Medicine Southeast University Nanjing China Department of Nephrology West China Hospital Sichuan University Chengdu Sichuan China Department of Radiation Oncology Shanghai Proton and Heavy Ion Center Fudan University Cancer Hospital Shanghai Key Laboratory of Radiation Oncology (20dz2261000) Shanghai Engineering Research Center of Proton and Heavy Ion Radiation Therapy Shanghai China Beijing Neurosurgical Institute, Capital Medical University, Beijing 100050, China From the Department of Cardiology (C.Z., L.W.), Daping Hospital, Third Military Medical University, Chongqing, People’s Republic of China; Departments of Pediatrics (C.Z., Z.W., H.L., P.Y., S.Z., L.D.Z., P.A.J.), Physiology and Biophysics (P.A.J.), and Internal Medicine (G.M.E.), Georgetown University Medical Center, Washington, DC; Department of Physiology and Biophysics (U.H.), Case Western Reserve School of Medicine, Cleveland, Ohio; and Department of Pathology (R.A.F.), Virginia University for... Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, 100070 Beijing, China;; Beijing Neurosurgical Institute, 100070 Beijing, China; Department of Chemistry, College of Science Hebei Agricultural University Lingyusi Road 289 Baoding 071001 P. R. China State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, Fujian 361102, China; State−Province Joint Engineering Laboratory of Targeted Drugs from Natural Products, Xiamen University, Xiamen, Fujian 361102, China Center for Tissue Engineering and Regenerative Medicine Union Hospital Huazhong University of Science and Technology Wuhan Hubei 430022 China; Department of Gastrointestinal Surgery Union Hospital Huazhong University of Science & Technology Wuhan Hubei 430022 China Department of Infectious Diseases, Qilu Hospital, Shandong University, Jinan, Shandong, China Department of Thoracic Surgery, Shenzhen People's Hospital, 2nd Clinical Medical College of Jinan University, Shenzhen, Guangdong 518020, P.R.China Peking University Institute of Hematology, Peking University People's Hospital, Beijing 100044, China Beijing Hospital; China Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, Sichuan - China Department of Statistics, University of Pittsburgh, Pittsburgh, PA 15260, USA Laboratory for Bone and Joint Diseases RIKEN Center for Integrative Medical Sciences Tokyo Japan; Department of Medical Genetics, Institute of Basic Medical Sciences Peking Union Medical College and Chinese Academy of Medical Sciences Beijing China Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY Shaanxi Collaborative Innovation Center of Chinese Medicinal Resources Industrialization Shaanxi University of Chinese Medicine Xianyang China; Shaanxi Province Key Laboratory of New Drugs and Chinese Medicine Foundation Research Xianyang China Department of Vascular Surgery, General Hospital of Tianjin Medical University, Tianjin, China University of Chinese Academy of Sciences Jiangsu Collaborative Innovation Center of Biomedical Functional Materials and Jiangsu Key Laboratory of New Power Batteries; School of Chemistry and Materials Science; Nanjing Normal University; Nanjing 210023; China Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, China Peking University People's Hospital, Peking University Institute of Hematolgy, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing 100044, China. laiyueyun1008@sina.com. School of Sciences, Wuhan University of Technology, Wuhan, Hubei 430070, China; Center for High Pressure Science and Technology Research, Zhengzhou University of Light Industry, Zhengzhou, 450002, China Department of General Surgery Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai China; Laboratory of General Surgery Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai China; Institute of Biliary Tract Disease Shanghai Jiao Tong University School of Medicine Shanghai China Department of Orthopaedics Xijing Hospital, Fourth Military Medical University Xi'an China Department of Molecular Neuropathology Beijing Neurosurgical Institute Capital Medical University Beijing China Pre Hospital Emergency Department, Shandong Otolaryngology Hospital Affiliated to Shandong University (West Hospital of Shandong Provincial Hospital), Shandong 250117, China CAS Key Laboratory of Bio-Medical Diagnostics, Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou 215163, China Department of Pathophysiology, Nanjing Medical University, Nanjing 211166, China. State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Research and Development Center for Fine Chemicals, Guizhou University, Guiyang 550025, P. R. China Department of Computer Science University of Miami Coral Gables Florida USA Department of Pharmacology, School of Basic Medical Sciences Xi'an Jiaotong University Xi'an Shaanxi China Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China Department of Medical Microbiology, School of Medicine Nanchang University Nanchang China; Department of Medical Microbiology School of Queen Mary of Nanchang University Nanchang China Department of Pharmaceutics, Jinling Hospital, Nanjing University School of Medicine, Nanjing 210002, China Department of Aerospace Medicine, Fourth Military Medical University, Xi’an, China Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai 201203, China. Key Laboratory of Cluster Science of Ministry of Education, Beijing Key Laboratory of Photoelectronic/Electrophotonic, School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing 100081, China Department of Electrical and Computer Engineering, University of Texas at Austin, Austin, TX 78712; Department of Pediatrics, College of Clinical Medicine, Dali University, Dali, Yunnan 671099, China. erklili@sina.com. Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China Department of Spine Surgery, The Third Hospital of Hebei Medical University, Shijiazhuang, PR China Department of Molecular Neuropathology, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China Chinese PLA General Hospital Department of Orthopaedics Beijing China Institute of Life Sciences Jiangsu University Zhenjiang China Department of Medical Biophysics, University of Western Ontario, London, Ontario, Canada. Research Center for Tissue Engineering and Regenerative Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China; Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China †Division of Clinical Immunology and Rheumatology, University of Alabama, Birmingham, AL 35294; and Department of Nephrology, the First Affiliated Hospital, Zhengzhou University, Zhengzhou, China. 3Department of Neurosurgery, Sahlgrenska University Hospital, Gothenburg, Sweden.; 4Beijing Neurosurgical Institute, Capital Medical University, Beijing, China.; 5Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China. Department of Molecular Neuropathology, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China; Chinese Glioma Cooperative Group (CGCG), China Department of Orthopaedic Oncology, Xijing Hospital Affiliated to the Fourth Military Medical University, Xi'an, China. Department of Pathology Beijing Hospital National Center of Gerontology Institute of Geriatric Medicine Chinese Academy of Medical Sciences Beijing P.R. China From the Department of Biological Sciences, State University of New York, College of Optometry, New York, New York; and the Department of Radiology, Beijing Friendship Hospital Capital Medical University Beijing China Department of Orthopaedics, Chinese PLA General Hospital, Beijing, PR China; Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, People’s Republic of China; Laboratory of Marine Drugs and Biological Products, National Laboratory for Marine Science and Technology, Qingdao, People’s Republic of China State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Road, Shanghai 200032, China, and Department of Chemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China Department of Epidemiology & Population Health, Albert Einstein College of Medicine, Bronx, NY 10461, USA Department of Geriatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Wuhan 430030, China Department of Oral Medicine, West China College of Stomatology, Sichuan University, Chengdu 610041, China. Key Laboratory of Rubber-Plastics of Ministry of Education/Shandong Province (QUST), School of Polymer Science and Engineering, Qingdao University of Science and Technology, 53-Zhengzhou Road, Qingdao 266042, China Department of Radiology Beijing Anzhen Hospital, Capital Medical University Beijing China Department of Orthopaedics, General Hospital of the Chinese People’s Liberation Army, Beijing, China Center for Bio/Molecular Science & Engineering, Naval Research Laboratory, Washington, D.C. 20375 Department of Orthopaedics of General Hospital of Northern Theater Command Shenyang Liaoning Province China Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering Beihang University Beijing People's Republic of China Department of General Surgery, Huashan Hospital, Fudan University, Shanghai, China Department of Hepatobiliary Surgery, First Affiliated Hospital, Xi'an Jiaotong University, Xi'an 710061, China Shanghai Key Laboratory of Functional Materials Chemistry & School of Pharmacy, East China University of Science and Technology, Shanghai, China, 200237, and School of Chemistry, University of Birmingham, Edgbaston, Birmingham, B15 2TT, England, U.K. Cancer Center, Gamma Knife Treatment Center, Zhejiang Provincial People’s Hospital , Affiliated People’s Hospital of Hangzhou Medical College , Hangzhou , China Albert Einstein College of Medicine, Bronx, NY; Hefei National Laboratory for Physical Sciences at Microscale, CAS Key Laboratory of Materials for Energy Conversion, Department of Materials Science and Engineering, School of Chemistry and Materials Science, University of Science and Technology of China 1 , Hefei, Anhui 230026, People’s Republic of China Department of Mechanical and Aerospace Engineering The Hong Kong University of Science and Technology Hong Kong SAR P. R. China State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & West China Hospital of Stomatology, Sichuan University, Chengdu, China; College of Stomatology, Chongqing Medical University, Chongqing, China Department of Ecology and Evolutionary Biology, Yale University, New Haven, Connecticut, USA; Department of Biostatistics, Yale School of Public Health, New Haven, Connecticut, USA National Shanghai Center for New Drug Safety Evaluation and Research China State Institute of Pharmaceutical Industry Shanghai China MOE Laboratory of Bioinorganic and Synthetic Chemistry, Lehn Institute of Functional Materials, School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, China Department of Genetics and Cell Biology, School of Basic Medicine, Qingdao University , Qingdao, Shandong , China; Department of Reproductive Medicine, The Affiliated Hospital of Qingdao University , Qingdao, Shandong , China School of Pharmacy Guizhou Medical University Guian New District Guizhou P. R. China Department of General Surgery Huashan Hospital, Fudan University Shanghai China Department of Respiratory and Critical Care Medicine Beijing Institute of Respiratory Medicine and Beijing Chao‐Yang Hospital, Capital Medical University Beijing China Department of Thoracic Surgery, Shenzhen People's Hospital, Shenzhen 518020, PR China National Clinical Research Center for Geriatric Disorders , Department of Geriatrics, Xiangya Hospital, , Changsha 410008, China; Central South University , Department of Geriatrics, Xiangya Hospital, , Changsha 410008, China; Department of Neurology , Xiangya Hospital, , Changsha 410008, China; Central South University , Xiangya Hospital, , Changsha 410008, China Authors' Affiliation: Liver Cancer Institute and Zhongshan Hospital, Fudan University, Shanghai, P.R. China Department of Cardiology, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, Japan Arizona State University, Tempe, AZ, USA Department of Mechanical Engineering and The University of Hong Kong, Hong Kong, Hong Kong SAR.; Department of Mechanical and Energy Engineering, SUSTECH-AISONO Joint Lab in Robotics, Southern University of Science and Technology, Shenzhen, China.; Department of Mechanical and Energy Engineering, Southern University of Science and Technology, Shenzhen, China. Institute of Antibody Engineering, School of Biotechnology Southern Medical University Guangzhou 510515 Guangdong China MOE Laboratory of Bioinorganic and Synthetic Chemistry Lehn Institute of Functional materials School of Chemistry Sun Yat-Sen University Guangzhou 510275 P.R. China Center for Bio/Molecular Science & Engineering, Code 6900, Naval Research Laboratory, Washington, D.C. 20375 Department of Thoracic Surgery, Cancer Hospital of Dalian University of Technology, Liaoning Cancer Hospital & Institute, Shenyang, China College of Chemistry and Chemical Engineering Key Laboratory of Chemical Additives for China National Light Industry Shaanxi University of Science and Technology Xi'an 710021 P. R. China Department of Hepatobiliary Surgery First affiliated hospital of Xi'an Jiaotong University Xi'an China Department of Radiology, Tongji Medical College, Huazhong University of Science and Technology, The Central Hospital of Wuhan, Wuhan, China Wuhan National High Magnetic Field Center and School of Physics, Huazhong University of Science and Technology, Wuhan, Hubei 430074, China Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China Institute of Mental Health; The Second Xiangya Hospital of Central South University; Changsha; China Emergency Department Xuanwu Hospital Capital Medical University Beijing, Beijing China University of Chinese Academy of Sciences, Beijing 100049, China. Shanghai Songjiang District Central Hospital, Shanghai, China Department of Thoracic Surgery, The 2nd Clinical Medical College of Jinan University, Shenzhen People's Hospital, Shenzhen, Guangdong 518020, P.R. China National Clinical Research Center for Geriatric Disorders, Department of Geriatrics, Xiangya Hospital, Central South University , Changsha , Hunan 410008 , China; Department of Neurology, Xiangya Hospital, Central South University , Changsha , Hunan 410008 , China; Hunan Key Laboratory of Molecular Precision Medicine, Xiangya Hospital, Central South University , Changsha , Hunan 410008, China Department of Radiation Oncology, Second Affiliated Hospital of Soochow University, Suzhou; Department of Radiation Oncology, Changshu Affiliated Hospital of Soochow University, Suzhou, China Department of Pathology, Beijing Hospital, National Center of Gerontology, Beijing 100730, China. CAS Key Laboratory of Bio Medical Diagnostics Suzhou Institute of Biomedical Engineering and Technology Chinese Academy of Sciences Suzhou 215163 China Shangdong Key Laboratory of Low-Altitude Airspace Surveillance Network Technology, QiLu Aerospace Information Research Institute, Jinan 250101, China State Key Laboratory of Organometallic Chemistry CAS Key Laboratory of Synthetic Chemistry of Natural Substances Center for Excellence in Molecular Synthesis Shanghai Institute of Organic Chemistry Chinese Academy of Sciences 345 Lingling Road Shanghai 200032 China *Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294; Department of Chemistry, Capital Normal University, Xisanhuan North Road. 105, Beijing 100048, China Department of Pathology, Beijing Hospital; National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Science, Beijing 100730, China. Center for OPTical IMagery Analysis and Learning, Northwestern Polytechnical University, Xi'an 710072, China Institute of Mental Health The Second Xiangya Hospital of Central South University Changsha China Institute of Neuroscience, State Key Laboratory of Neuroscience, Key Laboratory of Primate Neurobiology, CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences , Shanghai200031, China Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China; Department of Molecular Neuropathology, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China; Chinese Glioma Cooperative Group (CGCG), Beijing, China Department of Hepatobiliary Surgery The First Affiliated Hospital of Xi'an Jiaotong University Xi'an 710061 China Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai, China Nankai University 1 School of Physics, , Tianjin 300071, China Department of General Surgery Xinhua Hospital Shanghai Jiao Tong University School of Medicine Shanghai China; Shanghai Research Center of Biliary Tract Disease Shanghai China; Institute of Biliary Tract Disease Shanghai Jiao Tong University School of Medicine Shanghai China Department of General Surgery, Clinical Medical College of Yangzhou University, Huaihai Road No.7, Yangzhou 225001, China Division of Nanomaterials and Chemistry, Hefei National Laboratory for Physical Sciences at Microscale, Department of Chemistry, National Synchrotron Radiation Laboratory, University of Science and Technology of China, Hefei, Anhui 230026, People's Republic of China. Cancer Institute, Peking Union Medical College and Chinese Academy of Medical Sciences Department of Biology, Duke University, Durham, NC 27708 United States Naval Research Laboratory, 4555 Overlook Ave SW, Washington, DC 20375, USA College of Life Sciences, Shanxi Agricultural University, Jinzhong 030801, China State Key Laboratory of Advanced Metallurgy; School of Metallurgical and Ecological Engineering; University of Science and Technology Beijing (USTB); Beijing, P. R. China College of Bioscience and Biotechnology; Hunan Agricultural University; Changsha; China Department of Plastic Surgery, Changhai Hospital Second Military Medical University Shanghai China From the Department of Cardiology (C.Z., Y.L., D.H.), Daping Hospital, and Xinqiao Hospital (L.H.), Third Military Medical University, Chongqing, People’s Republic of China; Departments of Pediatrics (Z.W., P.Y., S.Z., J.E.J., L.D.A., G.M.E., P.A.J.), Physiology and Biophysics (P.A.J.), and Internal Medicine (G.M.E.), Georgetown University Medical Center, Washington DC; Department of Physiology and Biophysics (U.H.), Case Western Reserve School of Medicine, Cleveland, Ohio; and Department of... Department of Thoracic Surgery, Shenzhen People's Hospital, Shenzhen 518020, China ; Department of Neurosurgery Beijing Tiantan Hospital, Capital Medical University Beijing China Department of Gastroenterology, Ningbo First Hospital, Ningbo, Zhejiang 315000, P.R. China Department of Ecology and Evolutionary Biology, Yale University, 165 Prospect Street, New Haven, CT 06520, USA Department of Toxicology, Second Military Medical University, Shanghai 200433, China. Section of Molecular Genetics and Microbiology, School of Biological Science and Institute for Cellular and Molecular Biology, The University of Texas at Austin, Austin, Texas 78712,1 and Department of Applied Chemistry, School of Advanced Materials and Nanotechnology, Xidian University, Xi’an 710126, Shaanxi, China Research Center for Tissue Engineering and Regenerative Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China 430022; Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China 430022 Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Harbin Medical University, Hormone and Endocrinology Key Laboratory of Harbin Medical University Xuefu Road 246, Harbin 150080, China. College of Food and Bioengineering, South China University of Technology Guangzhou China Department of Graduate School, Qinghai University, Xining, Qinghai Province, China Pfizer Global Research and Development, CN 8000, Princeton, New Jersey 08543, United States Institute of Forensic Medicine West China School of Basic Science and Forensic Medicine Sichuan University Chengdu 610041 Sichuan China The Second Hospital of Wuhan Iron and Steel Group Corporation, Hubei, China Shaanxi Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Shaanxi Province Key Laboratory of New Drugs and Chinese Medicine Foundation Research, Shaanxi University of Chinese Medicine, Xianyang, P.R. China; Faculty of Pharmaceutical Sciences, Kumamoto University, 5–1 Oe-honmachi, Kumamoto 862, Japan Department of Gastrointestinal Surgery, The First Affiliated Hospital of Guangxi Medical University, 6 Shuangyong Road, Nanning, 530021 Guangxi Zhuang Autonomous Region, China; Guangxi Key Laboratory of Enhanced Recovery after Surgery for Gastrointestinal Cancer, Nanning, Guangxi Zhuang Autonomous Region, China Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao‐Yang Hospital Capital Medical University Beijing 100020 China Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science Soochow University 199 Ren-Ai Road Suzhou, Jiangsu 215123 China Department of Cardiology the First Affiliated Hospital of Harbin Medical University Harbin China Department of Microbiology and Immunology University of Saskatchewan Saskatoon SK Canada S7N 5E5 Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China. Department of Radiology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P.R., China Department of Chemical and Environmental Engineering, University of Nottingham, Ningbo, China Department of Hepatobiliary Surgery First Affiliated Hospital, Xi’an Jiaotong University Xi’an China State Key Laboratory of Organometallic Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, the People’s Republic of China State Key Laboratory of Organometallic Chemistry Center for Excellence in Molecular Synthesis Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences 345 Lingling Road Shanghai 200032 P. R. China Wenhua Liang, Qiuhua Deng, Xinguo Xiong, Wenlong Shao, Xiaoshun Shi, and Jianxing He, The First Affiliated Hospital of Guangzhou Medical University; Wenhua Liang, Qiuhua Deng, Xinguo Xiong, Wenlong Shao, Xiaoshun Shi, and Jianxing He, Guangzhou Institute of Respiratory Disease and China State Key Laboratory of Respiratory Disease; Wenhua Liang, Li Zhang, and Zhihua Zhu, Cancer Center of Sun Yat-Sen University, Guangzhou; Gening Jiang, Shanghai Pulmonary Hospital of Tongji University; Qun Wang, Shanghai... Department of Rehabilitation Medicine, the First People's Hospital of Lianyungang/the First Affiliated Hospital of Kangda College of Nanjing Medical University, 222061 Lianyungang, Jiangsu, China Beijing Neurosurgical Institute, Capital Medical University, Beijing, China; Beijing Tiantan Hospital, Capital Medical University, Beijing, China; Chinese Glioma Genome Atlas network (CGGA), Beijing, China Department of Cardiothoracic Surgery, General Hospital of Central Theater Command, Wuhan, Hubei, China State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of Ceramics Chinese Academy of Sciences 1295 Ding-xi Road Shanghai 200050 P. R. China Department of Epidemiology and Population Health (Z.W., B.A.P., J.X., D.B.H., T.W., K.A., R.C.K., R.D.B., Q.Q.), Albert Einstein College of Medicine, Bronx, New York. Department of Microbiology, the Chinese University of Hong Kong, the Prince of Wales Hospital, Hong Kong, China Chinese Glioma Genome Atlas Network (CGGA) Beijing China; Department of Neurosurgery Beijing Tiantan Hospital Capital Medical University Beijing China Department of Mechanical Engineering, The University of Hong Kong, Hong Kong SAR, China.; Department of Mechanical and Energy Engineering, Southern University of Science and Technology, Shenzhen, China. United States Naval Research Laboratory, Washington, DC, USA Department of Respiratory Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, China. State Key Laboratory of Silicon Materials, School of Materials Science and Engineering, Zhejiang University, Hangzhou 310027, P. R. China Department of Thoracic Surgery, Shenzhen People's Hospital, Shenzhen 518020, China; Beijing Neurosurgical Institute, Capital Medical University, Beijing, China Key Laboratory of Chemical Additives for China National Light Industry, College of Chemistry and Chemical Engineering, Shaanxi University of Science & Technology, Xi'an 710021, People's Republic of China School of Pharmaceutical Science & Technology, Tianjin Key Laboratory for Modern Drug Delivery & High Efficiency, and Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin University, Tianjin 300072, China Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, China. Key Laboratory of Energy Resources and Chemical Engineering and ‡Institute of Chemistry and Chemical Engineering, Ningxia University, 750021 Ningxia, China Co-construction Collaborative Innovation Center for Chinese Medicine Resources Industrialization by Shaanxi & Education Ministry/State Key Laboratory of Research & Development of Characteristic Qin Medicine Resources (Cultivation)/Shaanxi Innovative Drug Research Center, Shaanxi University of Chinese Medicine Xianyang 712046, China. School of Computer Science and Technology, Zhejiang University of Technology, Hangzhou 310023, China Cancer Center, The Affiliated Qingdao Central Hospital of Qingdao University The Second Affiliated Hospital of Medical College of Qingdao University Qingdao Shandong China Department of Molecular Neuropathology Beijing Neurosurgical Institute Capital Medical University Beijing China; Department of Neurosurgery Beijing Tiantan Hospital Capital Medical University Beijing China; Center of Brain Tumor Beijing Institute for Brain Disorders Beijing China; China National Clinical Research Center for Neurological Diseases Beijing China; Chinese Glioma Genome Atlas Network (CGGA) Beijing China National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences , Beijing 100101 , China Department of General Surgery, Guang’an Men Hospital, China Academy of Chinese Medical Sciences, Beijing, China State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China Solar Fuels Laboratory, School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798, Singapore Department of Chemical and Biomolecular Engineering, Division of Bioengineering, National University of Singapore, 10 Kent Ridge Crescent, Singapore 119260 Authors' Affiliations: 1Department of Hepatobiliary Surgery, First Affiliated Hospital of Xi'an Jiaotong University; 2Department of General Surgery, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, People's Republic of China; and 3Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas Department of Respiratory and Critical Care Medicine, Henan Provincial People’s Hospital, Zhengzhou University People's Hospital, Zhengzhou, Henan, China Department of Surgery, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China. Department of Urology Changzheng Hospital Naval Medical University Shanghai China Spice and Beverage Research Institute, Chinese Academy of Tropical Agricultural Sciences, Wanning, Hainan 571533, China. E-mail: sallywz618@163.com (Zheng). Department of Molecular Engineering, Graduate School of Engineering, Kyoto University, Kyotodaigaku Katsura, Nishikyo-ku, Kyoto 615−8510, Japan Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama Department of Gastrointestinal Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China Research Center for Tissue Engineering and Regenerative Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China 430022; Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China 430022 Naval Research Laboratory, Washington, DC, USA;NOVA Research Inc., Alexandria, Virginia, USA; Department of Ophthalmology, Beijing Hospital, Beijing 100730, China. Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University , Xi'an , China; Pancreatic Disease Centre of Xi’an Jiaotong University , Xi'an , China Hebei Key Laboratory of Organic Functional Molecules; College of Chemistry and Materials Science; Hebei Normal University; Shijiazhuang 050024; China Department of Thoracic Surgery Second Affiliated Hospital, Medical College of Ji'nan University, Shenzhen 518020, China. Department of Chemistry, Indiana University, Bloomington, Indiana 47405, United States Department of Hepatobiliary Surgery, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China. Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 2000503, China. Department of Precision Instrument, Tsinghua University, Beijing 100084, China; National Institute of Metrology, Beijing 100029, China Department of Mechanical Engineering, The University of Hong Kong, Hong Kong, China.; Department of Mechanical and Energy Engineering, Southern University of Science and Technology, Shenzhen, China. From the Department of Cardiology (C.Z.), Daping Hospital, Third Military Medical University, Chongqing, P.R. China; Departments of Pediatrics (C.Z., Z.W., L.D.A., G.M.E., P.A.J.) and Physiology and Biophysics (P.A.J.), and Internal Medicine (G.M.E.), Georgetown University Medical Center, Washington, DC; Department of Physiology and Biophysics (U.H.), Case Western Reserve School of Medicine, Cleveland, Ohio; Department of Pathology (R.A.F.), University of Virginia Health Sciences Center,... Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, PR China Hebei Key Laboratory of Integrative Medicine on Liver-Kidney Patterns Research, Shijiazhuang 050091, China; Institute of Integrative Medicine, College of Integrative Medicine, Hebei University of Chinese Medicine, Shijiazhuang 050200, China OraSure Technologies, Inc., Bethlehem, PA 18015, USA; Bristol Myers Squibb, Princeton, NJ 08540, USA Department of Hepatobiliary Surgery, The Third Xiangya Hospital, Central South University, Changsha 410013, China Department of Hepatobiliary Surgery, First Affiliated Hospital Medical College of Xi'an Jiaotong University, Xi'an, Shaanxi, China Frontier Laboratory of System Crop Design, Beijing 102206, China; Department of Biology, Duke University, Science Drive, Box 90388, Durham, NC 27708, USA. School of Civil and Hydraulic Engineering, Ningxia University, Yinchuan 750021, China. Xinhua College, Ningxia University, Yinchuan 750021, China. Department of Liver Disease Wuxi No. 5 People's Hospital Affiliated to Jiangnan University Wuxi China Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China. From the Departments of Pathology, Surgery, and Oncology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore MD; and the Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, and Department of Surgery and the Jefferson Pancreas, Biliary and Related Cancer Center, Thomas Jefferson University, Philadelphia PA. State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China Research Center of Blood Transfusion Medicine, Ministry of Education Key Laboratory of Laboratory Medicine, Department of Blood Transfusion, Zhejiang Provincial People's Hospital of Hangzhou Medical College, Hangzhou 310014, China State Key Laboratory of Silicate Materials for Architecture Wuhan University of Technology Wuhan 430070 P. R. China Beijing Centers for Preventive Medical Research, Beijing 100013, China. United Diagnostic and Research Center for Clinical Genetics, Women and Children’s Hospital, School of Medicine and School of Public Health, Xiamen University, Xiamen 361102, China; School of Pharmacy, Xiamen University, Xiamen 361102, China Gansu Key Laboratory of Polymer Materials, College of Chemistry and Chemical Engineering Northwest Normal University, Lanzhou 730070, People's Republic of China Peking University Third Hospital, Beijing, China. Department of Liver Surgery and Transplantation,Liver Cancer Institute, Zhongshan Hospital,Shanghai,China; Key Laboratory of Carcinogenesis and Cancer Invasion (Fudan University),Ministry of Education,Shanghai,China; Institute of Biomedical Sciences,Fudan University,Shanghai,China Department of Chemical Science and Engineering Kobe University 1‐1 Rokkodai, Nada Kobe 657‐8501 Japan Department of Hepatobillary Surgery, First Affiliated Hospital of Medical College of Xi'an Jiaotong University, Xi'an 710061, China. Department of Hepatobiliary Surgery, First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an, Shaanxi, China (mainland). Pathology Department, Beijing Hospital, National Center of Gerontology, Beijing, China Department of Pathology, Kunming Medical College, Kunming 650031 Shaanxi Collaborative Innovation Center of Chinese Medicine Resources Industrialization, Shaanxi University of Chinese Medicine, Xian Yang, China. Department of Genetics and Cell Biology Basic Medical College Qingdao University Qingdao China State Key Laboratory of Organometallic Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China School of Mechanical and Electronic Engineering, Nanjing Forestry University, Nanjing 210037, China Department of Chemical and Biological Engineering, Tufts University, Medford, MA 02155, USA. Institute of Antibody Engineering, School of Biotechnology, Southern Medical University, Guangzhou 510515, China State Key Laboratory of Microbial Metabolism and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China Department of Chinese Medicine Informatics, Beijing University of Chinese Medicine Beijing 102400, China. National Resource Center for Non-human Primates, Kunming Primate Research Center, and National Research Facility for Phenotypic & Genetic Analysis of Model Animals (Primate Facility), Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China; University of Chinese Academy of Sciences, Beijing, China; Institute of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, State Key Laboratory of Neuroscience, CAS Key Laboratory of Primate Neurobiology, Chinese Academy of Sciences, Shanghai, China; Shanghai Center for Brain Science and Brain-inspired Intelligence Technology, Shanghai, China Department of Orthopedics; PLA General Hospital; Beijing 100853; P. R. China Gonghexin Community Health Service Center, Shanghai, China. Department of General Surgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200001, China School of Chemical Engineering, Zhengzhou University, Zhengzhou 450001, PR China From the Heinrich-Pette-Institute, Department of Cell and Virus Genetics, Hamburg, Germany; and the Hannover Medical School, Department of Hematology and Oncology, Hannover, Germany. Department of Orthopedics, General Hospital of The People's Liberation Army, Beijing 100853, P.R. China Jiangsu Collaborative Innovation Centre of Biomedical Functional Materials and Jiangsu Key Laboratory of New Power Batteries School of Chemistry and Materials Science Nanjing Normal University Nanjing Jiangsu 210023 China 2Ciphergen Biosystems, Inc., Fremont, California Department of Orthopedics Trauma and Microsurgery, Zhongnan Hospital Wuhan University Wuhan China Department of Thyroid and Breast Surgery, Yijishan Hospital of Wannan Medical College, Wuhu, Anhui 241001, P.R. China Department of Biological Sciences, SUNY College of Optometry, New York, New York. State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic Chemistry Chinese Academy of Sciences 345 Lingling Road Shanghai 200032 China School of Telecommunications Engineering, Xidian University, Xi’an 710071, China Department of Hepatobiliary Surgery, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China Beijing Advanced Innovation Center for Soft Matter Science and Engineering, College of Life Science and Technology Beijing University of Chemical Technology Beijing China Department of Thoracic Surgery, Tianjin Chest Hospital, Tianjin 300000, China. Department of Nephrology, West China Hospital, Sichuan University, Chengdu, Sichuan 610000, P.R. China School of Pharmaceutical Science and Technology, Tianjin Key Laboratory for Modern Drug Delivery and High Efficiency, and Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin University, Tianjin, 300072, China; State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin 300071, China Department of Critical Care Medicine of People's Hospital of Maoming City, Guangdong, China State Key Laboratory of Organometallic Chemistry and Shanghai Mass Spectrometry Center, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Road, Shanghai 200032, P. R. China, and Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, China Key Laboratory of Particle Astrophysics & Experimental Physics Division & Computing Center, Institute of High Energy Physics, Chinese Academy of Sciences, 100049 Beijing, China.; Tianfu Cosmic Ray Research Center, 610000 Chengdu, Sichuan, China.; State Key Laboratory of Particle Detection and Electronics, China. College of Chemistry and Bioengineering, Hunan University of Science and Engineering, Yongzhou, Hunan Province 425000, China Department of Nephrology, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, China Departments of aGenetics, MOE Laboratory of Bioinorganic and Synthetic Chemistry Lehn Institute of Functional Materials School of Chemistry Sun Yat-Sen University Guangzhou 510275 China College of Bioscience and Biotechnology, Hunan Agricultural University, Changsha 410128, China. wz8918@163.com Department of Mechanical Engineering, The University of Hong Kong, Pokfulam Road, Hong Kong, China. Department of Pediatrics, West China Second University Hospital of Sichuan University, Chengdu, Sichuan - China Department of Chemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong SAR, China State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Department of Orthodontics, West China Hospital of Stomatology Sichuan University Chengdu China *National Key Laboratory of Plant Molecular Genetics, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200032, China; Department of Hepatobiliary Surgery, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, China Department of Emergency, 3th Hospital, Beijing University, Beijing 100083, China Hebei Key Lab of Power Plant Flue Gas Multi-Pollutants Control, Department of Environmental Science and Engineering, North China Electric Power University, Baoding, 071003, PR China Department of Animal Medicine, Agricultural College of Yanbian University, Yanji, Jilin, China Guangdong Provincial Key Laboratory of Nano-Micro Materials Research; School of Chemical Biology & Biotechnology; Peking University Shenzhen Graduate School; Shenzhen; P. R. China Department of Pharmacology Nanomedicine Engineering Laboratory of Jilin Province College of Basic Medical Sciences Jilin University Changchun 130021 China; CAS Key Laboratory of Bio‐Medical Diagnostics Suzhou Institute of Biomedical Engineering and Technology Chinese Academy of Sciences Suzhou 215163 China Henan University of Chinese Medicine Zhengzhou 450046,China. College of Biology and Agricultural Resources, Huanggang Normal University, Huanggang, China Department of Geriatrics, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China The Department of Rheumatology, The Second Affiliated Hospital of Dalian Medical University, Dalian, China State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Science, Shenyang 110016, China Research Center for Tissue Engineering and Regenerative Medicine Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430022 China; Department of Gastrointestinal Surgery Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430022 China; Minimally Invasive Surgery Medical Research Center of Hubei Province Wuhan 430022 China Department of General Surgery, Northern Jiangsu Province Hospital, Clinical Medical College, Yangzhou University, Institute of General Surgery—Yangzhou, Yangzhou, P.R. China Beijing Municipal Ecological and Environmental Monitoring Center, Beijing 100048, China. Beijing Key Laboratory of Airborne Particulate Matter Monitoring Technology, Beijing 100048, China. Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx Academy of Chinese Medicine Science Henan University of Chinese Medicine Zhengzhou Henan People's Republic of China; Sino‐British Research Center for Molecular Oncology, National Center for the International Research in Cell and Gene Therapy, School of Basic Sciences, Academy of Medical Sciences Zhengzhou University Zhengzhou Henan People's Republic of China Department of Hepatobiliary Surgery, The First Affiliated Hospital, Medical College, Xi'an Jiaotong University, Xi'an, Shaanxi, 710061, P. R. China. State Key Laboratory of Organometallic Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, P.R. China Department of Colorectal Surgery, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China Department of Gastrointestinal Surgery, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University , Shanghai 200127 , China General Surgery Department Renji Hospital Shanghai Jiaotong University School of Medicine Shanghai China Department of Pathophysiology, College of Medicine, Zhejiang University, Hangzhou 310031, China. CAS Key Laboratory of Nano-Bio Interface, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou, 215123, China National Institute of Biological Sciences Beijing 102206 China Co-Innovation Center for Sustainable Forestry in Southern China, College of Biology and the Environment, Nanjing Forestry University, Nanjing, Jiangsu, China. Department of Ophthalmology, The First College of Clinical Medical Science, Yichang Central People's Hospital, China Three Gorges University, Yichang, China. JYAMS PET Research and Development Limited, Nanjing, People's Republic of China. Department of Hepatobiliary and Pancreas Surgery, First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an 710061, Shaanxi Province, China State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin 300071, China;; College of Life Sciences, Nankai University, Tianjin 300071, China; Department of Radiology Beijing Friendship Hospital, Capital Medical University Beijing China College of Materials Science and Engineering; China Jiliang University; Hangzhou; China Division of Vascular Surgery Department of Surgery Feinberg School of Medicine Northwestern University Chicago IL 60611 USA State Key Laboratory of Organometallic Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, P. R. China Department of Obstetrics and Gynecology, Affiliated Hospital of Nantong University, Nantong, China Liver Cancer Institute Zhongshan Hospital Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Fudan University Shanghai China Department of Orthopedics, General Hospital of Northern Theater Command , Shenyang 110016 , Liaoning , China Beijing Key Laboratory of Vegetable Germplasms Improvement, Key Laboratory of Biology and Genetics Improvement of Horticultural Crops (North China), National Engineering Research Center for Vegetables, State Key Laboratory of Vegetable Biobreeding, Beijing Vegetable Research Center, Beijing Academy of Agriculture and Forestry Sciences, Beijing 100097, China State Key Laboratory of Loess and Quaternary Geology, IEE, CAS Xi'an 710075 P.R. China Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Veterinary MedicineChina Agricultural University 100193 Beijing China Key Laboratory of Engineering Plastics and Beijing National Laboratory for Molecular Sciences; Institute of Chemistry; Chinese Academy of Sciences; Beijing 100190; China Department of Colorectal Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China Department of Nuclear Medicine, Jincheng Anthracitic Coal Mining Group General Hospital, Beishidian, Jincheng, Shanxi 048006, P.R. China Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education and Yunnan Province, State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, School of Chemical Science and Technology, Yunnan University, Kunming, Yunnan 650091, P. R. China Department of Emergency Medicine and Chest Pain Center, Qilu Hospital of Shandong University, Jinan, China;; Clinical Research Center for Emergency and Critical Care Medicine of Shandong Province, Institute of Emergency and Critical Care Medicine of Shandong University, Qilu Hospital of Shandong University, Jinan, China;; Key Laboratory of Emergency and Critical Care Medicine of Shandong Province, Key Laboratory of Cardiopulmonary-Cerebral Resuscitation Research of Shandong Province, Qilu Hospital of Shandong University, Jinan, China;; The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese Ministry of Health and Chinese Academy of Medical Sciences; The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine; Qilu Hospital of Shandong University, Jinan, China; Department of Molecular Neuropathology, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China; Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China; Center of Brain Tumor, Beijing Institute for Brain Disorders, Beijing, China; China National Clinical Research Center for Neurological Diseases, Beijing, China; Chinese Glioma Genome Atlas Network (CGGA), Beijing, China School of Communication Center for Cognitive and Brain Sciences, The Ohio State University Guangdong Key Lab of Nano−Micro Material Research, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen 518055, China Harbin Institute of Technology; Ministry of Industry and Information Technology Department of Occupational and Environmental Health, School of Public Health Jilin University Changchun China College of Chemistry and Environmental Engineering, Sichuan University of Science and Engineering, Zigong, Sichuan 643000, China CAS Key Laboratory of Biomedical Diagnostics, Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Science (CAS), 88 Keling Road, Suzhou 215163, Jiangsu, People’s Republic of China School of Physics; Key Laboratory of Functional Polymer Materials of Ministry of Education, and Collaborative Innovation Center of Chemical Science and Engineering (Tianjin); Nankai University; Tianjin; China Department of Colorectal Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China. wangzhong@mail.sic.ac.cn Chinese Academy of Sciences; University of Chinese Academy of Sciences CAS Key Laboratory for Nano-Bio Interface, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou, 215123, China 1 Department of Computer Science, 2Informatics Institute and 3C. Bond Life Science Center, University of Missouri, Columbia, MO 65211, USA From the Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Faculty of Life Sciences, Northwest University, Taibai, Xi’an, China (Z.W., C.L., Y.Y.); Department of Cardiothoracic Surgery, Wuhan General Hospital of The People’s Liberation Army, China (Z.W.) School of Advanced Materials and Nanotechnology Xidian University Xi'an Shaanxi 710071 P.R. China Department of Mechanical Engineering, University of Michigan, Ann Arbor, MI, USA JYAMS PET Research and Development Limited, No. 568 Longmian Ave, Nanjing, 211100, P. R. China State Key Laboratory of Oral Diseases,National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China. Radiology Department of Neurosurgery Beijing Tiantan Hospital Capital Medical University Beijing China Institute of Military Veterinary medicine; Academy of Military Medical Sciences; Changchun China State Key Laboratory of Silicon Materials, Department of Materials Science and Engineering, Zhejiang University, Hangzhou 310027, People’s Republic of China Department of Abdominal Surgical Oncology, Cancer Hospital of Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100021, China. Antarctic Great Wall Ecology National Observation and Research Station, Polar Research Institute of China, Ministry of Natural Resources, Shanghai 200136, China; Key Laboratory for Polar Science, Polar Research Institute of China, Ministry of Natural Resources, Shanghai 200136, China Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, People's Republic of China.; Department of Surgical Intensive Care Unit, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, People's Republic of China. Hepatobiliary Surgery, Huai'an Second People's Hospital/Huai'an Hospital Xuzhou Medical University Jiangsu China School of Engineering, Huzhou University, Huzhou 313000, China Department of Intensive Care Medicine, Army Medical Center of PLA, Chongqing, China (mainland) 1 Department of Computer Science, 2 Informatics Institute and 3 C. Bond Life Science Center, University of Missouri, Columbia, MO 65211, USA School of Physics, Nankai University, Tianjin 300071, China School of Chemistry and Chemical Engineering, Yangzhou, University, Yangzhou 225002, China Department of Pharmacology, School of Medicine, Xi’an Jiaotong University, Xi’an, China; Department of Pharmacy, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, China Department of Hepatobiliary Surgery, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China Department of Colorectal Surgery, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. Department of Infectious Diseases, Qilu Hospital, Cheeloo College of Medicine Shandong University Ji′nan China CAS Key Laboratory of Bio-Medical Diagnostics, Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou 215163, China; University of Chinese Academy of Sciences, Beijing 100049, China Department of Hepatobiliary Surgery First Affiliated Hospital of Xi’an Jiaotong University Xi’an Shaanxi China School of Computer Science, Hunan First Normal University, Changsha 410205. w8614@ hotmail.com. Department of Nephrology, West China Hospital, Sichuan University, No.37, Guoxue alley, Chengdu, Sichuan, China Department of Psychiatry The Second Xiangya Hospital Central South University Changsha China State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry (SIOC), Chinese Academy of Sciences, 354 Fenglin Road, Shanghai 200032, P. R. China, and Graduate School of Pharmaceutical Sciences, Nagoya City University, Mizuho, Nagoya 467-8603, Japan Department of AIDS Research, State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China. Department of Hepatobiliary Surgery Department of Gastrointestinal Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, P.R.�China College of Environmental Sciences and Engineering, Peking University, Beijing Key Laboratory for Solid Waste Utilization and Management, Beijing, People’s Republic of China Key Laboratory of Nutrition and Metabolism Institute for Nutritional Sciences Shanghai Institutes for Biological Sciences Graduate School of the Chinese Academy of Sciences Chinese Academy of Sciences Shanghai China Department of Infectious Diseases Wuxi No. 5 People's Hospital Wuxi China Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China Department of Respiratory and Critical Care Medicine, Zhengzhou University People's Hospital, Zhengzhou, China. Department of Thoracic Surgery, Tianjin Chest Hospital, Tianjin 300000, P.R. China Shanghai Key Laboratory of Forensic Medicine, Institute of Forensic Science, Ministry of Justice, PR China, Shanghai 200063, China. wangzhengtim@163.com Guangdong Provincial Key Lab of Nano-Micro Material Research School of Chemical Biology and Biotechnology Shenzhen Graduate School Peking University Shenzhen 518055 China Shanghai Institute of Ceramics; Chinese Academy of Sciences; Shanghai; P. R. China Beijing Friendship Hospital—Affiliate of Capital University of Medical Sciences, Beijing Tropical Medicine Research Institute, 95 Yong An Road, Beijing 100050, People's Republic of China Department of Pathology, Beijing Hospital, National Center of Gerontology, Beijing, China Division of Infectious Diseases and School of Science, Hainan University, Haikou 570228, People's Republic of China Center for Bio/Molecular Science and Engineering, Naval Research Laboratory, Washington, DC, USA Department of Medical Genetics Institute of Basic Medical Sciences, Peking Union Medical College and Chinese Academy of Medical Sciences Beijing People's Republic of China; Laboratory for Bone and Joint Diseases RIKEN Center for Integrative Medical Sciences Tokyo Japan Department of Neurology Huashan Hospital State Key Laboratory of Medical Neurobiology Fudan University Shanghai China Department of Ecology and Evolutionary Biology Yale University 165 Prospect Street New Haven CT 06520 USA; Department of Biostatistics Yale School of Public Health New Haven CT 06510 USA Wuhan National High Magnetic Field Center and School of Physics, Huazhong University of Science and Technology, Wuhan 430074, China From the Division of Pediatric Nephrology, Department of Pediatrics, Georgetown University of School of Medicine, Washington, DC (Z.W.); Department of Cardiology, Daping Hospital, The Third Military Medical University, Chongqing, P.R. China (C.Z.); Chongqing Institute of Cardiology, Chongqing, P.R. China; Division of Nephrology, Department of Medicine (V.A.M.V., X.W., L.D.A., J.E.J., Y.Y., M.R.W., I.A., P.A.J.) and Department of Physiology (P.A.J.), University of Maryland School of Medicine,... State Key Laboratory of Oral Diseases National Clinical, Research Center for Oral Diseases Chinese Academy of Medical Sciences, Research Unit of Oral Carcinogenesis and Management West China, Hospital of Stomatology Sichuan University 610041 Chengdu P.R. China Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, China. Research and Development Information, AstraZeneca, Shanghai, China Shanghai Bao Pharmaceuticals Co. Ltd. Shanghai China Department of Respiratory and Critical Medicine People's Hospital of Zhengzhou University Zhengzhou Henan Province China Department of Colorectal Surgery; Cancer Hospital; Chinese Academy of Medical Sciences; Peking Union Medical College; Beijing China College of Bioscience and Biotechnology, Hunan Agricultural University, Changsha, Hunan 410128, PR China; Hunan Engineering Laboratory for Pollution Control and Waste Utilization in Swine, Production, Changsha 410128, PR China School of Communication Center for Cognitive and Brain Sciences The Ohio State University Innovation Center of Nanomedicine Kawasaki Institute of Industrial Promotion 3‐25‐14, Tonomachi, Kawasaki‐ku Kawasaki 210‐0821 Japan From Department of Pediatrics (C.Z., Z.Y., Z.W., L.D.A., G.M.E., P.A.J.), Physiology and Biophysics (Z.Y., P.A.J.), and Internal Medicine (G.M.E.), Division of Nephrology and Hypertension and Center for Hypertension and Renal Disease Research (D.W., C.S.W., W.J.W.), Georgetown University Medical Center, Washington, DC; Department of Pathology (R.A.F.), Virginia University for the Health Sciences, Charlottesville; Department of Cardiology (C.Z.), Daping Hospital, Third Military Medical University,... Department of Hepatobiliary Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China, Department of Clinical Medicine, Second Military Medical University, Shanghai, China Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Fudan University, Shanghai, China Department of Nephrology, The First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou City, Henan Province, China Institute of Refrigeration and Cryogenics, Shanghai Jiao Tong University, Shanghai 200240, China Department of Pathology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine Chinese Academy of Medical Sciences Beijing China State Key Laboratory of Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China School of Physical Science and Technology, Southwest Jiaotong University, Chengdu 610031, China Department of Cardiothoracic Surgery, Taizhou Hospital of Zhejiang Province, Taizhou, China School of Physics, Key Laboratory of Functional Polymer Materials of Ministry of Education, Nankai University, and Collaborative Innovation Center of Chemical Science and Engineering (Tianjin); Tianjin; China Hebei Key Laboratory of Integrative Medicine on Liver-Kidney Patterns, Institute of Integrative Medicine, College of Integrative Medicine, Hebei University of Chinese Medicine, Shijiazhuang, People’s Republic of China Department of Biology, Duke University, Durham, North Carolina, USA. Department of Orthopedics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450000, P.R. China Department of Computer Science, University of Miami , 330M Ungar Building, 1365 Memorial Drive, Coral Gables, 33124-4245, FL , USA 1 Department of Veterinary Pharmacology, College of Veterinary Medicine, China Agricultural University, Beijing, China Department of Infectious Diseases, Qilu Hospital, Shandong University, Jinan, China; Department of Colorectal Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China Department of Hepatobiliary Surgery, First Affiliated Hospital, Xi’an Jiaotong University, China Department of Forensic Biology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, Sichuan, China. Department of Biostatistics, Yale University, 135 College Street, New Haven, CT 06520-8034, USA State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China; Department of Operative Dentistry and Endodontics, West China School of Stomatology, Sichuan University, Chengdu, Sichuan, China 1Guangdong Lung Cancer Institute, Guangdong General Hospital, and Guangdong Academy of Medical Sciences, Guangzhou, P.R. China. Institute of Neuroscience, State Key Laboratory of Neuroscience, Key Laboratory of Primate Neurobiology; Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences; Shanghai 200031 People's Republic of China MOE Laboratory of Bioinorganic and Synthetic Chemistry Lehn Institute of Functional Materials School of Chemistry Sun Yat-Sen University Guangzhou 510275 China; College of Chemistry and Chemical Engineering Key Laboratory of Chemical Additives for China National Light Industry Shaanxi University of Science and Technology Xi'an 710021 China Department of Epidemiology and Population Health Albert Einstein College of Medicine Bronx New York USA Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China Department of Biological Science, College of Optometry, State University of New York, New York City, New York. Institute of Industrial Science, The University of Tokyo, Meguro, Tokyo, Japan The Medical School of Zhejiang University Hangzhou, Zhejiang, China. 3Department of Gastrointestinal surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. State Key Laboratory of Molecular Oncology Cancer Institute (Hospital), Peking Union Medical College and Chinese Academy of Medical Sciences Beijing China Jiangsu Key Laboratory for Biodiversity and Biotechnology, Jiangsu Key Laboratory for Microbes and Functional Genomics, Jiangsu Engineering and Technology Research Center for Microbiology, College of Life Sciences, Nanjing Normal University, Nanjing 210046, People's Republic of China State Key Laboratory of Plant Cell and Chromosome Engineering Institute of Genetics and Developmental Biology Chinese Academy of Sciences Beijing 100101 China Department of Biostatistics, Yale University, New Haven, Connecticut, USA; Department of Ecology and Evolutionary Biology, Yale University, New Haven, Connecticut, USA †The University of Alabama at Birmingham, Department of Medicine, Division of Clinical Immunology and Rheumatology, and the Veterans Administration Medical Center, Birmingham, AL 35294; and Research Initiative for Supra-Materials, Shinshu University, 4-17-1 Wakasato, Nagano 380-8553, Japan Surgery Centre of Diabetes Mellitus, Capital Medical University Affiliated Beijing Shijitan Hospital, Beijing 100038, P.R. China School of Chemistry and Chemical Engineering; Yancheng Institute of Technology; Yancheng 224051; China School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225002, China Jian Zhou, Lei Yu, Jie Hu, Zhi Dai, Xiaowu Huang, Zheng Wang, Shuangjian Qiu, Xiaoying Wang, Guohuan Yang, Huichuan Sun, Zhaoyou Tang, and Jia Fan, Liver Cancer Institute, Zhongshan Hospital, Fudan University; Jian Zhou, Xue Gao, Hongguang Zhu, and Jia Fan, Institute of Biomedical Sciences, Fudan University; Jie-Fei Wang, Zhiyong Zhang, Shanghai Public Health Clinic Center; Shaohua Lu, Zhongshan Hospital, Fudan University; Ying Wu and Hongguang Zhu, Shanghai Medical College, Fudan University, Shanghai,... Department of Pathology, Beijing Hospital, Beijing 100730, China. Center for Bio/Molecular Science and Engineering, Naval Research Laboratory, Washington, DC 20375, USA Department of Physics University of Science and Technology Beijing Beijing 100083 P. R. China School of Physics; Key Laboratory of Functional Polymer Materials of Ministry of Education; Nankai University, and Collaborative Innovation Center of Chemical Science and Engineering (Tianjin); Tianjin, 300071; China School of Physics and Key Laboratory of Functional Polymer Materials of the Ministry of Education, Nankai University, Tianjin 300071, China Department of Epidemiology and Population Health Center for Bio/Molecular Science & Engineering Naval Research Laboratory Washington DC USA Department of Nephrology The First Affiliated Hospital of Zhengzhou University Zhengzhou China Department of Hepatobiliary Surgery; The Third Xiangya Hospital; Central South University; Changsha; PR China CAS Key Laboratory of Nano‐Bio Interface Suzhou Institute of Nano‐Tech and NanoBionics Chinese Academy of Sciences Suzhou 215123 China Department of Urology Changhai Hospital Naval Medical University Shanghai China Department of Nursing, Huadong Hospital Affiliated to Fudan University, Shanghai, China Department of Hematology, Beijing Aerospace Center Hospital, Beijing 100049, China. Beijing Municipal Center for Disease Prevention and Control, HePingLi Middle Street 16, Beijing, China 100013 School of Information Engineering, Hubei University of Economics, Wuhan 430205, China; Hubei Internet Finance Information Engineering Technology Research Center, Hubei University of Economics, Wuhan 430205, China Department of Ecology and Evolutionary Biology, Yale University, New Haven; Department of Biostatistics, Yale School of Public Health, New Haven, Connecticut Department of Orthopaedics, Xuanwu Hospital Capital Medical University Beijing China The Department of Orthopaedics The First Medical Center of the Chinese PLA General Hospital Beijing China Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA. Department of Infectious Diseases Renmin Hospital of Wuhan University Wuhan China Liver Cancer Institute, Fudan University, Shanghai 200032, China. Department of Hepatobiliary Surgery, First Affiliated Hospital of Medical College, Xi’an Jiaotong University, Xi’an, Shaanxi 710061, China Contribution from Beijing National Laboratory for Molecular Sciences, State Key Laboratory for Structural Chemistry of Unstable and Stable Species, and Department of Chemical Biology, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China Department of Pharmacy, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China and School of Medicine, Southeast University, Nanjing, China Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China; Department of Neurosurgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China Center for Bio/Molecular Science and Engineering, U.S. Naval Research Laboratory, Washington, DC, USA School of Pharmacy and Shanghai Key Laboratory of New Drug Design, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China Beijing Neurosurgical Institute, Capital Medical University, Beijing, PR China; Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, PR China Department of Pathology; The First People's Hospital of Yangzhou; 368 Hanjiang Middle Road Yangzhou China United States Naval Research Laboratory 4555 Overlook Ave. SW Washington DC 20375 USA Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai. wangzheng@mail.sic.ac.cn Department of General Surgery,Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200001, China. wangzh1972@126.com Department of Ecology and Evolutionary Biology, Yale University, POB 208106, 165 Prospect Street, New Haven, CT 06520-8106, USA Department of Cardiology, Yijishan Hospital of Wannan Medical College, Wuhu, China.; Department of Cardiology, Yijishan Hospital of Wannan Medical College, Wuhu, China. Center for High Pressure Science State Key Lab of Metastable Materials Science and Technology Yanshan University Qinhuangdao 066004 China Beijing Vegetable Research Center (BVRC), Beijing Academy of Agriculture and Forestry Science (BAAFS), Beijing 100097, China; National Engineering Research Center for Vegetables , Beijing 100097, China; Key Laboratory of Biology and Genetic Improvement of Horticultural Crops (North China), Ministry of Agriculture , Beijing 100097, China; Beijing Key Laboratory of Vegetable Germplasm Improvement , Beijing 100097, China Children's National Medical Center, Center for Molecular Physiology Research, Department of Pediatrics, George Washington School of Medicine and Health Sciences, Washington, DC; and Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China Department of Computer Science University of Miami Coral Gables FL USA School of Nano‐Tech and Nano‐Bionics University of Science and Technology of China (USTC) Hefei 230026 China; CAS Key Laboratory of Nano‐Bio Interface Suzhou Institute of Nano‐Tech and Nano‐Bionics Chinese Academy of Sciences Suzhou 215123 China Chengdu National Agricultural Science and Technology Center (NASC) Institute of Urban Agriculture, Chinese Academy of Agricultural Sciences (IUA-CAAS), , Chengdu, 610213, China Department of Mechanical Engineering, The University of Hong Kong, Hong Kong, China.; HKU Shenzhen Institute of Research and Innovation (HKU-SIRI), Shenzhen, China. Department of General Surgery, Huashan Hospital & Cancer Metastasis Institute Fudan University Shanghai China School of Information Engineering, Xijing University, Xi’an, China Zhongshan Hospital, Shanghai, China. Department of Pathology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. College of Horticulture Northwest A&F University Yangling 712100 Shaanxi China Department of Hepatobiliary Surgery, The First Affiliated Hospital, Xi’an Jiaotong University, Xi’an 710061, China Department of General Surgery, Comprehensive Breast Health Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China School of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China Division of Clinical Immunology and Rheumatology, Department of Medicine Department of Pharmacology; Nanomedicine Engineering Laboratory of Jilin Province; College of Basic Medical Sciences; Jilin University; Changchun 130021 Research Initiative for Supra-Materials, Interdisciplinary Cluster for Cutting Edge Research, Shinshu University, Nagano-shi, Nagano 380-8553, Japan; Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China State Key Laboratory of Oganometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, People’s Republic of China State Key Laboratory of High‐efficiency Utilization of Coal and Green Chemical Engineering School of Chemistry and Chemical Engineering Ningxia University Yinchuan 750021 P. R. China School of Pharmacy, Anhui University of Chinese Medicine, Anhui Key Laboratory of Modern Chinese Materia Medica, Hefei, China School of Chemistry and Environment, South China Normal University, Guangzhou 510006, P. R. China. Department of Nephrology, West China Hospital, Sichuan University, Chengdu, China. Pharmaceutical Informatics Institute, College of Pharmaceutical Sciences Zhejiang University Hangzhou China Department of Gastroenterology, Peking Union Medical College Hospital, Peking Union Medical College Chinese Academy of Medical Sciences Beijing China Zilkha Neurogenetic Institute, Keck School of Medicine University of Southern California Los Angeles California 90089 aDepartment of Statistics bDepartment of Biostatistics, University of Pittsburgh, Pittsburgh, Pennsylvania cPopulation Health Sciences, Harvard University, Cambridge, Massachusetts dDepartment of Epidemiology eDepartment of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania fDepartment of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, California gDepartment of Psychiatry, Rush University School of Medicine, Chicago, Illinois hDepartment of Psychiatry iDepartment of Neurology, The Johns Hopkins University School of Medicine, Baltimore, Maryland jDepartment of Radiology, Northwestern University, Evanston, Illinois kDepartment of Epidemiology, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, Maryland lDepartment of Psychiatry mDepartment of Neurology nDepartment of Psychology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. School of Chemistry & Chemical Engineering, Sun Yat-sen University, 135 Xingangxi Lu, Guangzhou, 510275, China Department of Ophthalmology, Beijing hospital, China. Department of Gastrointestinal Surgery Renji Hospital Affiliated Shanghai Jiao Tong University School of Medicine Shanghai China National Center for Geriatric Medicine/Beijing Hospital, 100730 Beijing, China. Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China State Key Laboratory of Microbial Metabolism Joint International Research Laboratory of Metabolic and Developmental Sciences School of Life Sciences and Biotechnology Shanghai Jiao Tong University Shanghai China Affiliated Hospital of Gansu University of Chinese Medicine Department of Chemistry The Hong Kong University of Science and Technology Hong Kong Institute of Chemical Safety, Chinese Academy of Inspection and Quarantine, Beijing 100124, People’s Republic of China National Clinical Research Centre for Geriatric Disorders, Department of Geriatrics, Xiangya Hospital, Central South University, Changsha, Hunan, China Department of Radiology, Oncology Hospital, Guangxi Medical University, Nanning, Department of Molecular Neuropathology Beijing Neurosurgical Institute Capital Medical University Beijing China; Department of Neurosurgery Beijing Tiantan Hospital Capital Medical University Beijing China; Chinese Glioma Genome Atlas network Beijing China Institute of Forensic Medicine West China School of Basic Medical Sciences & Forensic Medicine Sichuan University Chengdu P. R. China Department of Oncology Xi'an Central Hospital Xi'an Jiaotong University School of Medicine Xi'an China Department of Oncology Radiotherapy, Tianjin Huanhu Hospital, Tianjin Huanhu Hospital, Tianjin, China School of Chemistry, South China Normal University, Guangzhou 510006, P. R. China Department of Gastroenterology,PUMC Hospital,CAMS and PUMC,Beijing 100730,China. Department of Liver Surgery & Transplantation,Liver Cancer Institute, Zhongshan Hospital, Fudan University,Shanghai,China; Key Laboratory of Carcinogenesis and Cancer Invasion,Ministry of Education of the People's Republic of China,Shanghai,China; Shanghai Key Laboratory of Organ Transplantation,Shanghai,China State Key Laboratory of Organometallic Chemistry Center for Excellence in Molecular Synthesis Shanghai Institute of Organic Chemistry Chinese Academy of Sciences 345 Lingling Road Shanghai 200032 P. R. China Department of Psychiatry the First Affiliated Hospital Zhejiang University School of Medicine Hangzhou China; The Key Laboratory of Mental Disorder's Management in Zhejiang Province Hangzhou China; Brain Research Institute Zhejiang University Hangzhou China; Zhejiang Engineering Center for Mathematical Mental Health Hangzhou China Department of Cardiology, The 960th Hospital of the Joint Service Support Force of the People's Liberation Army, Jinan, Shandong Province, China. Department of Orthopaedics, Xijing Hospital, The Fourth Military Medical University, Xi’an, 710032, P. R. China School of Physics and Electronic Engineering, Zhengzhou University of Light Industry, Zhengzhou, Henan, 450002, China; Henan key laboratory of magnetoelectric information functional materials, Zhengzhou, Henan, 450002, China Peking University People Hospital, Peking University Institute of Hematology, Beijing, China. Research Center for Tissue Engineering and Regenerative Medicine Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430022 China; Department of Gastrointestinal Surgery Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430022 China Department of Stem Cell Biology and Regenerative Medicine Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research Keck School of Medicine University of Southern California Los Angeles CA USA Innovation Center of NanoMedicine (iCONM), Kawasaki Institute of Industrial Promotion, Kawasaki-ku, Kawasaki 210-0821, Japan Key Laboratory for Advanced Materials and Research Institute of Industrial Catalysis, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai 200237, P. R. China; State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou 350116, P. R. China Center for Orthopaedic Science and Translational Medicine Department of Orthopaedics Shanghai Tenth People's Hospital School of Medicine Tongji University 301 Yanchang Road Shanghai 200072 P.R. China; School of Medicine Anhui University of Science and Technology Huainan 232001 P. R. China Department of Orthopedics Trauma and Microsurgery Zhongnan Hospital of Wuhan University Wuhan China Key Lab of Structure Dynamic Behavior and Control (Harbin Institute of Technology), Ministry of Education, Heilongjiang, Harbin, 150090, China; School of Civil Engineering, Harbin Institute of Technology, Heilongjiang, Harbin, 150090, China School of Advanced Materials and Nanotechnology; Xidian University; Xi'an 710071; China Department of Gastrointestinal Surgery Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430022 China; Research Center for Tissue Engineering and Regenerative Medicine Union Hospital Huazhong University of Science and Technology Wuhan 430022 China School of Management, Harbin Institute of Technology, Harbin, China. 1Beijing Neurosurgical Institute, Capital Medical University, Beijing, China. National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China Department of Mechanical Engineering and The University of Hong Kong, Hong Kong, Hong Kong. State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Center for Research and Development of Fine Chemicals, Guizhou University, Guiyang 550025, P. R. China School of Chemical Engineering, Zhengzhou University, Zhengzhou, 450001, PR China Laboratory Medicine Center, The First School of Clinical Medicine, Southern Medical University; Department of Clinical Laboratory, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong State Key Laboratory of Organometallic Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China From the Department of Cardiology (C.Z.), Daping Hospital, Third Military Medical University, Chongqing, P.R. China; Departments of Pediatrics (Z.Y., Z.W., J.J., X.W., J.A., P.A.J.), Physiology and Biophysics (Z.Y., P.A.J.), and Medicine (G.M.E.), Georgetown University Medical Center, Washington, DC; Departments of Medicine (A.J.M.) and Pathology (R.A.F.), University of Virginia Health Sciences Center, Charlottesville; Department of Physiology and Biophysics (U.H.), Case Western Reserve School of... Shaanxi Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Shaanxi Province Key Laboratory of New Drugs and Chinese Medicine Foundation Research, Shaanxi Rheumatism and Tumor Center of TCM Engineering Technology Research, Shaanxi University of Chinese Medicine Xianyang 712083, China. School of Chemical Engineering, Zhengzhou University, Zhengzhou 450001, China Department of General Surgery, Third Xiangya Hospital, Central South University, Changsha, China. From the Department of Biological Sciences, State University of New York, College of Optometry, New York, New York; School of Pharmaceutical Science & Technology Tianjin Key Laboratory for Modern Drug Delivery & High Efficiency Tianjin University Tianjin 300072 China Department of Molecular Genetics, Albert Einstein College of Medicine, Bronx, New York 10461 |
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