author/MD5_125b3d98a747d4b59ab13cdcbd14ccb9

http://rdf.ncbi.nlm.nih.gov/pubchem/author/MD5_125b3d98a747d4b59ab13cdcbd14ccb9

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Predicate	Object
family-name	Qian Zhang Zhang
name	Qian Zhang
given-name	Qian
organization-name	Department of Pharmacy, First Affiliated Hospital of Shantou University Medical College Shantou, Guangdong, China School of Computer Science, Zhongyuan University of Technology, Zhengzhou 450000, China Regeneron Pharmaceuticals Inc., Tarrytown, New York, USA The key Laboratory of Bioactive Materials; Ministry of Education; College of Life Sciences; Nankai University; Tianjin 300071 Division of Nephrology, National Clinical Research Center for Aging and Medicine, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai 200040, China Center for Reproductive Medicine, General Hospital, Ningxia Medical University, Yinchuan, Ningxia, China (mainland) Department of Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China College of Traditional Chinese Medicine, Hebei Medical University, Shijiazhuang 050091, China. Fachbereich Medizin der Johann Wolfgang Goethe-Universität, Dr. Senckenbergische Anatomie, Institut für Anatomie II, Frankfurt, Germany Department of Respiratory Medicine Nanjing Chest Hospital Nanjing China; Affiliated Nanjing Brain Hospital Nanjing Medical University Nanjing China State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing 100029, China Key Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, China Department of The Second Clinical College, Wuhan University, Wuchang, Wuhan 430071, P.R. China Carson International Cancer Centre, Shenzhen University General Hospital and Shenzhen University Clinical Medical Academy Centre, Shenzhen University, 1098 Xueyuan Road, Shenzhen Guangdong 518000, China; Key Laboratory of Optoelectronic Devices and Systems, College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, China; Health Science Center, School of Medicine, Shenzhen University, Shenzhen 518060, China Department of Critical Care Medicine, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China Genelux Corporation, San Diego Science Center, San Diego, CA 92109; and Institute of International Rivers and Ecological Security, Yunnan University, Kunming 650091, China. binkang@ynu.edu.cn. Department of Occupational and Environmental Health Key Laboratory of Environment and Health, Ministry of Education, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology Wuhan Hubei China Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, the Graduate School of the Chinese Academy of Sciences, Shanghai, People’s Republic of China Bristol Myers Squibb Research & Development, 700 Bay Road, Redwood City, California 94063, United States Fujian Provincial Key Laboratory of Plant Functional Biology and College of Life Sciences, Joint International Research Laboratory of Water and Nutrient in Crop and College of Resources and Environment Fujian Agriculture and Forestry University Fuzhou China Key Laboratory of Aging and Cancer Biology of Zhejiang Province Institute of Aging Research Hangzhou Normal University School of Medicine Hangzhou China Department of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital, Diabetes Research Center of Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China Department of Respiratory and Critical Care Medicine, The Affiliated Changzhou No.2 People’s Hospital of Nanjing Medical University, 29 Xinlong Road, Changzhou 213003, PR China Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University; China National Clinical Research Center for Neurological Diseases (NCRC-ND); Center of Stroke, Beijing Institute for Brain Disorders; Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease Department of Occupational and Environmental Health, Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China Department of Civil and Environmental Engineering, University of Hawaii at Manoa, Honolulu, Hawaii 96822, United States Institute of Nano Biomedicine and Engineering, School of Sensing Science and Engineering, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, 800 Dongchuan RD, Shanghai 200240, China Department of Infectious Diseases, Henan Provincial People’s Hospital, Zhengzhou, Henan Province, China Department of Pharmacology and Chemical Biology State Key Laboratory of Oncogenes and Related Genes Shanghai Universities Collaborative Innovation Center for Translational Medicine Shanghai Jiao Tong University School of Medicine 280 South Chongqing Road Shanghai 200025 China Center for Robust Speech Systems (CRSS), Erik Jonsson School of Engineering and Computer Science, University of Texas at Dallas , Richardson, Texas 75080, USA School of Materials Shenzhen Campus of Sun Yat‐sen University No. 66, Gongchang Road, Guangming District Shenzhen Guangdong 518107 China Department of Radiology The Second Affiliated Hospital of Soochow University Suzhou China Department of Classical Chinese Medicine, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China College of Chemical Engineering, Nanjing Forestry University, Nanjing, China Department of Radiology Shandong Chambroad HoldingGroup Co., Ltd., Binzhou 256599, China Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention National Institute for Nutrition and Health, Beijing, China Asian International River Center, Yunnan University, Kunming 650091, China. zhangqian20062007@163.com School of Resources and Environmental Engineering Shandong University of Technology Zibo Shandong China Department of Internal Medicine VIP, The First Affiliated Hospital of Xinjiang Medical University, Xinjiang Uyghur Autonomous Region 830011, P.R. China School of Chemistry and Materials Science, Jiangsu Normal University, Jiangsu 221008, China Program in Emerging Infectious Diseases, Duke-NUS Graduate Medical School, Singapore 169857;; Center for Bioimaging Sciences, Department of Biological Sciences, National University of Singapore, Singapore 117557; State Key Laboratory of Metastable Materials Science and Technology Yanshan University Qinhuangdao 066004 China Department of Pharmacy Affiliated Hospital of Nanjing University of Chinese Medicine Nanjing China West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China College of Acupuncture-Moxibustion and Tuina, Guangxi University of CM, Nanning 530200, China. Key Laboratory for Organic Electronics & Information Displays; Institute of Advanced Materials (IAM); Nanjing University of Posts & Telecommunications; Nanjing; China Vehicle Measurement, Control and Safety Key Laboratory of Sichuan Province, School of Automobile and Transportation, Xihua University, Chengdu 610039, PR China Department of Endocrinology, Nanfang Hospital Southern Medical University Guangzhou China Department of Respiratory and Critical Care Medicine, Tianjin Medical University General Hospital Tianjin 300052, China. Department of Hematology, The First Affiliated Hospital of Nanchang University; Department of Lymphomatous diseases, Institute of Hematology, Academy of Clinical Medicine of Jiangxi Province Department of Pediatrics , Peking University First Hospital-Mi Yun Hospital , Beijing , P.R. China Medical Technology and Practice Patterns Institute, Bethesda, Maryland Department of Emergency Medicine Lianyungang Clinical College of Nanjing Medical University Lianyungang China Orthopedics, The First Center Hospital of Baoding, Baoding, Hebei, China Department of Cardiology, Beijing Chao-yang Hospital, Capital Medical University, Beijing, China. Department of Pharmaceutical Analysis China Pharmaceutical University Nanjing 210009 China Key Laboratory of Optic-electric Sensing and Analytical Chemistry for Life Science, MOE; Shandong Key Laboratory of Biochemical Analysis; Key Laboratory of Analytical Chemistry for Life Science in Universities of Shandong; College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao, Shandong 266042, P. R. China School of Dentistry, Hospital of Stomatology; Tianjin Medical University; Tianjin China School of Food Science and Engineering; Wuhan Polytechnic University; Wuhan; China From the Department of Nutrition and Food Hygiene, School of Public Health (Y.W., Q.Z., L.Y., M.S., M.M., Q.L., K.Z., S.L., M.L., F.Z., F.N., W.L.), China Medical University, Shenyang; Department of Neurosurgery (Z. Zhang, Z. Zou, D.L., C.H., X.B., F.H., H.W., L.D.), the Fifth Medical Centre, Chinese PLA General Hospital (Former 307th Hospital of the PLA), Beijing; and Department of Neurology (L.W., K.W.), the First Affiliated Hospital of Anhui Medical University, Hefei, China. Carson International Cancer Centre, Shenzhen University General Hospital and Shenzhen University Clinical Medical Academy Centre, Shenzhen University, 1098 Xueyuan Road, Shenzhen, Guangdong 518000, China; Key Laboratory of Optoelectronic Devices and Systems, College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, China; Health Science Center, School of Medicine, Shenzhen University, Shenzhen 518060, China National Key Laboratory of Medical Immunology and Institute of Immunology, Second Military Medical University, Shanghai 200433, China; Department of Occupational and Environmental Health, the Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment, School of Public Health Fourth Military Medical University Xi'an China The Center for New Drug Safety Evaluation and Research, Inner Mongolia Medical University, Hohhot, China; The Center for New Drug Screening Engineering and Research of Inner Mongolia Autonomous Region, Inner Mongolia Medical University, Hohhot, China; School of Pharmacy, Inner Mongolia Medical University, Hohhot, China Center for Plant Water‐use and Nutrition Regulation and College of Life Sciences, Joint International Research Laboratory of Water and Nutrient in Crop Fujian Agriculture and Forestry University Fuzhou China College of Medicine and Biological Information Engineering, Northeastern University, Shenyang, Liaoning, P.R. China Department of Clinical Aerospace Medicine, Fourth Military Medical University, Xi’an, China Department of Biochemistry and Molecular Biology, Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL 33136; and Department of Cardiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College; Department of Cardiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College College of Mechanical and Electrical Engineering Gansu Agricultural University Lanzhou China From the University of Wisconsin Comprehensive Cancer Center, Madison, WI; Hospital K, National Cancer Institute, Ha Noi; Danang General Hospital, Da Nang; Hue Central Hospital, Hue; Hai Phong General Hospital, Hai Phong; Khanh Hoa Provincial Hospital, Nha Trang City, Socialist Republic of Vietnam; People’s Hospital of Haimen City, Haimen, Jiangsu, People’s Republic of China; Baylor College of Medicine, Houston, TX; and Virginia Commonwealth University, Richmond, VA. Department of Cardiology, The First Hospital of Jilin University, Changchun, Jilin Province, China. School of Chemistry and Chemical Engineering Liaocheng University Liaocheng Shandong China Key Laboratory of Animal Physiology and Biochemistry Ministry of Agriculture College of Veterinary Medicine Nanjing Agricultural University Nanjing China Key Laboratory of Horticultural Plant Biology (MOE), College of Horticulture and Forestry Science, Huazhong Agricultural University, PR China School of Biology and Biological Engineering, South China University of Technology, Guangzhou Higher Education Mega Centre, Panyu District, Guangzhou 510006, China Department of Radiation Oncology, Fudan University Shanghai Cancer Center; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China. Key Laboratory of Endocrinology of National Health Commission, Diabetes Research Center of Chinese Academy of Medical Sciences Department of Endocrinology, Peking Union Medical College Hospital Peking Union Medical College, Chinese Academy of Medical Sciences Beijing China The First Clinical School of Nanjing Medical University, Nanjing 210029, P.R. China Regeneron Pharmaceuticals, Tarrytown, United States Department of Medical Oncology The First People's Hospital of Zhengzhou ZhengZhou China Department of Oral and Maxillofacial Trauma Orthognathic Plastic Surgery Nanjing Stomatological Hospital, Medical School of Nanjing University Nanjing China Department of Pathology Binzhou Medical College Affiliated Hospital Binzhou China School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China Department of Materials Science and Engineering, National University of Singapore, Singapore 117574, Singapore Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China 1Pathology and Laboratory Medicine, Departments of Department of Chemistry, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, and Laboratory of Advanced Materials, Fudan University, Shanghai 200438, China Department of Radiation Oncology, Fudan University Shanghai Cancer Center; Department of Oncology, Shanghai Medical College, Fudan University, 270 Dong An Road, Shanghai 200032, China College of Horticulture, Hebei Agricultural University, Baoding, Hebei, China; Hebei Key Laboratory of Vegetable Germplasm Innovation and Utilization, BaoDing, Hebei, China Department of Chemistry, Northeast Normal University, 130024 Changchun, China, and Laboratory of Organic Chemistry, ETH Zurich, 8093 Zurich, Switzerland Department of Reconstructive and Plastic Surgery, The General Hospital of Shenyang Military Region, Shenyang, China Department of Dermatology, The Third People’s Hospital of Hangzhou, Zhejiang, China College of Chemistry and Chemical Engineering, Chemical Synthesis and Pollution Control Key Laboratory of Sichuan Province, China West Normal University, Nanchong 637000, China Anhui University of CM, Hefei 230012, China. Department of Epidemiology and Biostatistic, School of Public Health, Anhui Medical University, Hefei 230032, China. Division of Neuropsychiatry and Psychosomatics, Department of Neurology, Beijing Psychosomatic Disease Consultation Center, Xuanwu Hospital, National Center for Neurological Disorders, National Clinical Research Center for Geriatric Diseases, Capital Medical University, Beijing 100053, China Institute of Anatomy, Experimental Neurobiology Goethe‐University Frankfurt/Main Germany Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO 80523; Department of Clinical Pharmacy School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Guangzhou 510275, China Department of Urology, Peking University First Hospital and Institute of Urology, National Research Center for Genitourinary Oncology, Beijing 100034, China Department of Cardiology, the First Hospital of Jilin University, Changchun, Jilin Province, China. Department of Pathology, University of Pennsylvania, Philadelphia, PA; School of Materials Science and Engineering Institute of Materials Genome & Big Data Harbin Institute of Technology Shenzhen 518055 P. R. China Taiyuan University of Technology College of Chemistry and Molecular Science Wuhan University Wuhan 430072 China Department of Molecular Medicine, Scripps Research Institute , La Jolla , CA 92037 , USA Heilongjiang University of Chinese Medicine, Harbin, China; The First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, China From the Division of Cardiovascular Medicine (Z.Z., X.H., D.T., D.X., V.T., Q.Z., K.A.G., Y.X., R.L., N.C.), Department of Internal Medicine, University of California, Davis; the Department of Veterans Affairs (N.C.), Northern California Health Care System, Mather, Calif; the Center for Calcium and Learning (H.-S.S.), Division of Life Sciences, Korea Institute of Science and Technology, Seoul, Korea; and the Department of Physiology (Z.Z.), Henan Medical University, Zhingzhou, China. Key Laboratory of Functional Polymer Materials of Ministry of Education, Institute of Polymer Chemistry, Nankai University, Tianjin 300071, China Department of Colorectal Cancer Surgery, the Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, People's Republic of China; Colorectal Cancer Institute of Harbin Medical University, Harbin, Heilongjiang, People's Republic of China Liaoning Provincial Key Laboratory for Green Synthesis and Preparative Chemistry of Advanced Materials (Liaoning University); Shenyang 110036, China School of Chemical Engineering and Technology; Tianjin University; Tianjin 300050; China School of Electronic and Information Engineering; Beihang University; Beijing; China Department of Chemistry, Center for Self-Assembled Chemical Structures (CSACS), Université de Montréal, C.P. 6128, Succ. Centre Ville, Montréal, Québec, Canada H3C 3J7 Jilin Province Key Laboratory of Organic Functional Molecular Design & Synthesis; Department of Chemistry; Northeast Normal University; Changchun 130024; China National Cancer Center ‐ Cancer Hospital, Chinese Academy of Medical Sciences (CAMS) & Peking Union Medical College (PUMC) Beijing China School of Marine Sciences, Guangxi University, Nanning 530004, China; Guangxi Laboratory on the Study of Coral Reefs in the South China Sea, Nanning 530003, China Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai, China Department of Endocrinology, PUMC Hospital, Beijing, China. The Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology Jiangnan University Wuxi 214122 China China Research Institute of Daily Chemical Industry 030001 Taiyuan People's Republic of China Key Laboratory for NeuroInformation of Ministry of Education, High‐Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, Center for Information in Medicine, School of Life Science and Technology University of Electronic Science and Technology of China Chengdu China; School of Foreign Languages, Southwest Petroleum University Chengdu China Department of Pediatric Surgery, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China. Department of Microorganism Examination, Tropical Medicine, Shenzhen Center for Disease Control and Prevention, Shenzhen, China. National Key Laboratory of Medical Immunology Institute of Immunology Naval Medical University Shanghai 200433 P. R. China Department of Clinical Pharmacology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210000, China Key Laboratory for Deep Processing of Major Grain and Oil, Ministry of Education, Hubei Key Laboratory for Processing and Transformation of Agricultural Products, Wuhan Polytechnic University, Wuhan 430023, P. R. China; Xiangyang Academy of Agricultural Sciences, Hubei Province 441004, P. R. China Department of Pathophysiology, Anhui Medical University, Hefei 230032, China Department of Chemistry and Biochemistry; University of Maryland; College Park; USA Department of Clinical Pharmacology, The Second Hospital of Anhui Medical University, Hefei, China; Anhui Provincial Institute of Translational Medicine, Hefei, China Laboratory of Epidemiology and Population Sciences National Institute on Aging, National Institutes of Health Bethesda MD Division of Nephrology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China. Department of Hematology, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China Department of Hematology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China Department of Chemistry; Northeast Normal University; Changchun 130024, China Department of Respiratory and Critical Care Medicine, The Affiliated Changzhou No. 2 People’s Hospital of Nanjing Medical University, Changzhou, Jiangsu, China Department of Respiratory and Critical Care Medicine, the Affiliated Changzhou No.2 People’s Hospital of Nanjing Medical University, Changzhou 213003, Jiangsu Province, China School of Chemistry and Chemical Engineering Frontiers Science Center for Transformative Molecules and National Center for Translational Medicine Shanghai Jiao Tong University Shanghai 200240 China Changchun Institute of Applied Chemistry; Chinese Academy of Sciences; Changchun, China School and Hospital of Stomatology, Tianjin Medical University, Tianjin 300070, China Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China Key Laboratory for Thin Film and Microfabrication Technology of the Ministry of Education; Department of Instrument Science and Engineering; School of Electronic Information and Electrical Engineering; Institute of Nano Biomedicine and Engineering; Shanghai Jiao Tong University Shanghai Jing'an District Tianmu West Road Community Health Service Center, Shanghai 200070, China. Department of Neurology, Hainan Branch of Chinese PLA General Hospital, Sanya 572013, China. College of Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, P.R.China Department of Applied Chemistry, Xi’an University of Technology, Xi’an, 710048, China Department of Chemistry, Northeast Normal University, Changchun 130024, China, State Key Laboratory and Institute of Elemento-organic Chemistry, Nankai University, Tianjin 300071, China, and Physical Department, Harbin Institute of Technology, Harbin 150001, China Department of Pediatrics, First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China. College of Environment, Hohai University, Nanjing, People’s Republic of China Key Laboratory of Industrial Biotechnology, Ministry of Education and School of Biotechnology, Jiangnan University, 1800 Lihu Road, Wuxi, Jiangsu 214122, China; National Engineering Laboratory for Cereal Fermentation Technology, Jiangnan University, 1800 Lihu Road, Wuxi, Jiangsu 214122, China; Science Center for Future Foods, School of Biotechnology, Jiangnan University, Wuxi 214122, China; Jiangsu Provisional Research Center for Bioactive Product Processing Technology, Jiangnan University, 1800 Lihu Road, Wuxi, Jiangsu 214122, China Wenzhou Central Hospital Wenzhou China School of Electronic Engineering, XI’AN University of Posts & Telecommunications, Xi’an 710121, China School of Chemistry and Chemical Engineering, Chongqing University of Technology, Chongqing 400054, China. Jinan Engineering Polytechnic, Jinan 250200, China Key Laboratory of Environmentally Friendly Chemistry and Application of Ministry of Education, College of Chemistry, Xiangtan University, Xiangtan 411105, P.R. China Jilin Province Key Laboratory of Organic Functional Molecular Design & Synthesis, Department of Chemistry, Northeast Normal University, Changchun 130024, P. R. China Institute of Energy Resources, China University of Geosciences, Beijing 100083, China; Key Laboratory of Marine Reservoir Evolution and Hydrocarbon Enrichment Mechanism, Ministry of Education, China University of Geosciences, Beijing 100083, China; Coal Reservoir Laboratory of National Engineering Research Center of CBM Development & Utilization, China University of Geosciences, Beijing 100083, China Key Laboratory of Functional Organic Molecule Design & Synthesis of Jilin Province, Department of Chemistry, Northeast Normal University, Changchun 130024, China; State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China Department of Dermatological Surgery, Hospital for Skin Diseases, Institute of Dermatology, Chinese Academy of Medical Science, Peking Union Medical College, Nanjing, Jiangsu, China Institute of Geographic Sciences and Natural Resources Research Chinese Academy of Sciences Beijing P. R. China Email: jsbwnmm@163.com. Marine College Shandong University at Weihai Weihai China Laboratory of Animal Cell Biology and Embryology College of Veterinary Medicine Nanjing Agricultural University Nanjing 210095 China School of Pharmacy; Guangdong Pharmaceutical University; Guangzhou 510006; China Department of Orthopaedic Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21205; Department of Nutrition and Health, China Agricultural University, Beijing 100193, China The Key Laboratory of Molecular Imaging Chinese Academy of Sciences The State Key Laboratory of Management and Control for Complex Systems Institute of Automation Chinese Academy of Sciences Beijing 100190 China Key Laboratory of Optic-electric Sensing and Analytical Chemistry for Life Science, MOE; Shandong Key Laboratory of Biochemical Analysis; Key Laboratory of Analytical Chemistry for Life Science in Universities of Shandong; College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, P.R. China Department of Respiratory Medicine Beijing Tongren Hospital, Capital Medical University Beijing China St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM UMR1163, 75015 Paris, France; Paris Cité University, Imagine Institute, 75015 Paris, France Central Laboratory, Peking University School and Hospital of Stomatology, Beijing, China. Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064 Department of Pharmacy, The Second Affiliated Hospital, Army Medical University, Chongqing 400037, P.R. China Department of Ultrasound, Xi’an Children’s Hospital, Xi’an, China State Key Laboratory of Medicinal Chemical Biology, 2011 Collaborative Innovation Center of Tianjin for Medical Epigenetics, College of Life Sciences, Nankai University, Tianjin, China Academy for Advanced Interdisciplinary Studies and ‡College of Engineering, Peking University, Beijing 100871, P. R. China College of Electrical Engineering, Yanshan University, Qinhuangdao 066004, China Department of Respiratory Medicine Affiliated Nanjing Brain Hospital, Nanjing Medical University Nanjing China; Clinical Center of Nanjing Respiratory Diseases and Imaging Nanjing China Pharmaceutical Sciences Research Centre, Laboratory of Veterinary Pharmacology and Toxicology, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, PR China Department of Emergency Medicine, Beijing Chaoyang Hospital, Capital Medical University, 8 Workers’ Stadium South Road, Chaoyang District, Beijing 100020, China National Institute for Nutrition and Food Safety, Chinese Center for Disease Control and Prevention, Beijing, China; Faculty of Veterinary Science, University of Sydney, Sydney, Australia Department of Hyperbaric, Changhai Hospital Second Military Medical University Shanghai China Key Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing 100193, China Authors' Affiliations: 1Eppley Institute for Research in Cancer and Allied Diseases; Departments of 2Biochemistry and Molecular Biology and 3Pathology and Microbiology, University of Nebraska Medical Center, Nebraska Medical Center, Omaha; Departments of 4Cancer Biology, 5Pathology, and 6Surgery, Thomas Jefferson University, Philadelphia, Philadelphia; 7Division of Oncology, Departments of Medicine and Pathology, Stanford University School of Medicine, Stanford; and 8Diabetes Center, Department of Medicine, University of California, San Francisco, California Department of Gynecology and Obstetrics, Tianjin Metabolic Diseases Hospital and Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin 300070, P.R. China Department of Applied Chemistry Xi'an University of Technology No. 5 South Jinhua Road Xi'an Shaanxi 710048 P. R. China Genelux Corporation (Q.Z., Y.A.Y., N.C., A.A.S.), San Diego Science Center, San Diego, California 92109 Graduate Institute of Environmental Engineering, National Taiwan University, Taipei, 106, Taiwan Center for Reproductive Medicine, Shandong University , Jinan , China; Key Laboratory of Reproductive Endocrinology of Ministry of Education, Shandong University , Jinan , China; Shandong Key Laboratory of Reproductive Medicine , Jinan , China; Shandong Provincial Clinical Research Center for Reproductive Health , Jinan , China; Shandong Technology Innovation Center for Reproductive Health , Jinan , China; National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University , Jinan , China College of Chemistry and Chemical Engineering; Qingdao University; Shandong 266071; P. R. China Department of General Surgery, Jiangsu Cancer Hospital and Jiangsu Institute of Cancer Research, The Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, Jiangsu 210009, P.R. China Shenzhen Center for Disease Control and Prevention, Shenzhen 518055, China Faculty of Materials Metallurgy and Chemistry, Jiangxi University of Science and Technology, Ganzhou 341000, PR China; Yichun Lithium New Energy Industry Research Institute, Jiangxi University of Science and Technology, Ganzhou 341000, PR China Department of Psychology, University of Leeds, Leeds, West Yorkshire, United Kingdom. Department of Pathology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430014, P.R. China Research Informatics, BC Children's Hospital Research Institute Vancouver British Columbia Canada BC Children’s Hospital Research Institute, University of British Columbia, Vancouver, BC, Canada Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO 80523 First Department of Mammary Surgery, The Third Affiliated Hospital of Kunming Medical University, Tumor Hospital of Yunnan Province, Kunming, Yunnan 650118, P.R. China State Key Laboratory for Advanced Metals and Materials School of Materials Science and Engineering University of Science and Technology Beijing Beijing 100083 China Thermal and Environmental Engineering Institute, School of Mechanical Engineering, Tongji University, Shanghai, People’s Republic of China; Shanghai Engineering Research Center of Multi-source Solid Wastes Co-processing and Energy Utilization, Shanghai, People' s Republic of China College of Chemistry and Life Science, Changchun University of Technology, Changchun, 130012, P.R. China Affiliated Hospital of Guizhou Medical University, Guiyang 550004, China. Peking Union Medical Colleague Hospital, Beijing 100730, China. Department of Educational Psychology and Learning System, Florida State University Obstetrics and Gynecology Department the 8^th People's Hospital of Shanghai Shanghai China Department of Chemistry; College of Chemistry and Chemical Engineering; MOE Key Laboratory of Spectrochemical Analysis and Instrumentation; and the Collaborative Innovation Center of Chemistry for Energy Materials (iChEM); Xiamen University Department of Ophthalmology, Xi'an Fourth Hospital, Shaanxi Ophthalmological Hospital, Xi'an 710004, Shaanxi Province, China. Divisions of Reproductive and Developmental Biology (A.K., X.W., T.D., Q.Z., B.C.P.), Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee 37232-2678 National Key Laboratory of Plant Molecular Genetics, CAS Center for Excellence in Molecular Plant Sciences, Shanghai Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai, China; University of the Chinese Academy of Sciences, Beijing, China Department of Endocrinology & Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China From the Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, China (S.K., X.L., D.Z., R.W., Y.Z., Q.Z., J.-z.Z.); China National Clinical Research Center for Neurological Diseases, Beijing (S.K., X.L., D.Z., R.W., Y.Z., Q.Z., J.-z.Z.); Center of Stroke, Beijing Institute for Brain Disorder, China (S.K., X.L., D.Z., R.W., Y.Z., Q.Z., J.-z.Z.) Division of Advanced Manufacturing, Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, China; Informatization and Industrialization Integration Research Institute, China Academy of Information and Communications Technology, Beijing 100191, China Teaching & Research Section of Nuclear Medicine Anhui Medical University Hefei Anhui 230032 People's Republic of China Department of Nuclear Medicine, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China Department of Endocrinology, Chinese PLA General Hospital, Beijing 100853, China Shanghai Key Laboratory of Advanced Polymeric Materials; State Key Laboratory of Bioreactor Engineering; Key Laboratory for Ultrafine Materials of Ministry of Education; School of Materials Science and Engineering; East China University of Science and Technology Department of Burn and Plastic Surgery, Linyi Central Hospital, Linyi, Shandong 276400, P.R. China Department of Pharmacy, Fenyang Hospital of Shanxi Province, Fenyang, China; School of Food and Biological Engineering Jiangsu University Zhenjiang Jiangsu China Department of Pharmaceutical Analysis School of Pharmacy Hebei Medical University 361 East Zhongshan Road Shijiazhuang 050017 P. R. China Department of Hepatology The Third Central Hospital of Tianjin Tianjin China; Tianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases Tianjin China; Artificial Cell Engineering Technology Research Center Tianjin China; Tianjin Institute of Hepatobiliary Disease Tianjin China Endoscopic Center of Nanjing Chest Hospital Nanjing Jiangsu 210029 People's Republic of China; Clinical Center of Nanjing Respiratory Diseases and Imaging Nanjing Jiangsu 210029 People's Republic of China Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, China National Clinical Research Center for Neurological Diseases; and State Key Laboratory of New Textile Materials and Advanced Processing Technologies, Hubei Key Laboratory of Biomass Fibers and Eco-Dyeing & Finishing, School of Textile Science and Engineering, Wuhan Textile University, Wuhan 430200, P. R. China School of Chemistry and Chemical Engineering, Chongqing University, Chongqing, China; Department of Pharmacy, China–Japan Friendship Hospital, Beijing, 100029, People’s Republic of China Department of Pathology,Beijing Tongren Hospital, Capital Medical University,Beijing 100730,China. Department of Stomatology, School and Hospital of Stomatology, Tianjin Medical University, Tianjin 300070, P.R. China Department of Pharmacy, The Second Affiliated Hospital of Army Medical University, ChongQing 400037, China Xi’an University of Technology, Xi’an, Shaanxi710048, China Beijing Key Laboratory of Traditional Chinese Veterinary Medicine, Animal Science and Technology College, Beijing University of Agriculture, No. 7 Beinong Road, Beijing 102206, China Office of Schistosomiasis Control, Chinese Center for Disease Control and Prevention, Beijing 100050, China. Institute of Poromechanics, Wuhan Polytechnic University, Wuhan, People’s Republic of China Fachbereich Physik Philipps Universität Marburg Marburg Germany Key Laboratory of Surveillance and Early-warning on Infectious Disease, Division of Infectious Diseases; Chinese Field Epidemiology Training Project, Chinese Center for Disease Control and Prevention, Beijing 102206, China. College of Horticulture, Sichuan Agricultural University, Chengdu, China; School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai, 264005, People’s Republic of China College of Chemical Engineering and Materials Science, Tianjin University of Science & Technology, TEDA, China Institute for Nutrition and Food Safety, Chinese Center for Disease Control and Prevention, Beijing 100050, China. Department of Pathology, Nanjing First Hospital Nanjing Medical University Nanjing China Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University , Chengdu, Sichuan , P.R. China School of Materials, Shenzhen Campus of Sun Yat-sen University, No. 66, Gongchang Road, Guangming District, Shenzhen 518107, China School of Chemistry and Environment, Beihang University, Beijing 100191, PR China Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.; University of Paris, Imagine Institute, Paris, France.; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, New York, USA. School of Pharmacy, Key Laboratory of Sichuan Province for Specific Structure of Small Molecule Drugs, Chengdu Medical College, Chengdu, China Veterinary Diagnosis Center and OIE Porcine Reproductive and Respiratory Syndrome Laboratory, China Animal Disease Control Center, Chaoyang District, Beijing, People's Republic of China; The General Hospital of Ningxia Medical University Yinchuan China; Key Laboratory of Fertility Preservation and Maintenance, Ministry of Education Ningxia Medical University Yinchuan China Heilongjiang University of Chinese Medicine, Harbin, China; The First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, China. College of Math and Physics, Langfang Normal University, Langfang, China State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Beijing Key Laboratory of Carcinogenesis and Translational Research, NMPA Key Laboratory for Research and Evaluation of Radiopharmaceuticals (National Medical Products Administration), Department of Nuclear Medicine, Peking University Cancer Hospital & Institute, Beijing 100142, China Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China, Changzhou Institute of Energy Storage Materials & Devices, Changzhou 213000, China College of Mechanical Engineering, Xi’an University of Science and Technology, Xi’an 710054, China School of Chemistry and Chemical Engineering, Chongqing University, Chongqing, PR China; The Department of Respiratory Medicine Beijing Tongren Hospital Capital Medical University Beijing School of Pharmacy, Nanjing University of Chinese Medicine Nanjing 210023, China. School of Environment and Energy, South China University of Technology, Guangzhou 510006, China Teaching and Research Section of Surgery Xiangnan University Affiliated Hospital Chenzhou Hunan China Endoscopic Center of Nanjing Chest Hospital Nanjing Jiangsu China; Clinical Center of Nanjing Respiratory Diseases and Imaging Nanjing Jiangsu China; Department of Respiratory Medicine Nanjing Chest Hospital Nanjing Jiangsu China Department of Human Anatomy, Zunyi Medical CollegeZunyi, Guizhou, China. Polymeric and Soft Materials Laboratory, School of Chemical Engineering and Advanced Institute of Materials Science, Changchun University of Technology, Changchun 130012, P. R. China Health Assessment and Management Center, University of Hong Kong-Shenzhen Hospital, Shenzhen 518053, China zhangq@hku-szh.org. Institute of Automation Chinese Academy of Science 95 ZhongGuanCun East Road Beijing 100190 China School of Rare Earths University of Science and Technology of China Hefei 230026 China; Ganjiang Innovation Academy Chinese Academy of Science Ganzhou 341000 China; State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences Fuzhou 350002 China; Xiamen Key Laboratory of Rare Earth Photoelectric Functional Materials Xiamen Institute of Rare Earth Materials Haixi Institute Chinese Academy of Sciences Fuzhou 350002 China National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, Beijing, China. Email: zhangqian@ninh.chinacdc.cn. Laboratory of Animal Cell Biology and Embryology, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, Jiangsu Province, China Key Laboratory of Agricultural Microbiology of Guizhou Province, College of Agriculture, Guizhou University, Guiyang 550025, China Department of NeurologyHainan Branch of Chinese People's Liberation Army General HospitalSanyaChina State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, China CCNU-uOttawa Joint Research Centre, Key Laboratory of Pesticides and Chemical Biology Ministry of Education, International Joint Research Center for Intelligent Biosensing Technology and Health, College of Chemistry, Central China Normal University (CCNU), Wuhan, Hubei 430079, P. R. China College of Veterinary Medicine Nanjing Agricultural University Nanjing People's Republic of China State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection Chinese Academy of Agricultural Science Beijing China Department of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital, Diabetes Research Center of Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, People’s Republic of China Department of Neurosurgery Beijing Tiantan Hospital Capital Medical University Beijing China; China National Clinical Research Center for Neurological Diseases Beijing China New Materials and Green Manufacturing Talent Introduction and Innovation Demonstration Base, Hubei University of Technology, Wuhan, China, 430068 Vector-borne Virus Research Center, Fujian Province Key Laboratory of Plant Virology, Fujian Agriculture and Forestry University, Fuzhou, Fujian 350002, People's Republic of China Key Laboratory of Functional Polymer Materials of Ministry of Education, Institute of Polymer Chemistry, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Nankai University, Tianjin 300071, China College of Animal Science and Technology, Northeast Agricultural University, Harbin 150030, China Key Laboratory of Coal Science and Technology of Ministry of Education and Shanxi Province Taiyuan University of Technology Taiyuan 030024 Shanxi China School of Materials Science and Engineering and Institute of Materials Genome & Big Data Harbin Institute of Technology Shenzhen 518055 China; State Key Laboratory of Advanced Welding and Joining Harbin Institute of Technology Harbin 150001 China Department of Rheumatology Taizhou First People’s Hospital Taizhou China Department of Infectious Diseases, Guizhou Provincial People’ s Hospital, Guiyang, Guizhou, China Institute of Nano Biomedicine and Engineering; Shanghai Engineering Center for Intelligent Diagnosis and Treatment Instrument; Department of Instrument Science & Engineering; School of Electronic Information and Electrical Engineering; Shanghai Jiao Tong University Department of Digestive China‐Japan Union Hospital affiliated to Jilin University Changchun China School of Optoelectronic Engineering, Chongqing University of Posts and Telecommunications, Chongqing 400065, People’s Republic of China Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, Beijing 100083, China; National Center for Nanoscience and Technology (NCNST), Beijing 100190, China; University of Chinese Academy of Sciences, Beijing 100049, China International Institute for Earth System Sciences, Nanjing University, Nanjing, Jiangsu, China The Second Department of Joint Surgery, Third Hospital of Hebei Medical University, 139 Ziqiang Road, Shijiazhuang, Hebei 050051, P.R. China Key Laboratory for Medical Virology, National Health Commission, National Institute for Viral Disease Control and Prevention, China CDC, Beijing, China Key Laboratory of Plant Gene Resources and Biotechnology for Carbon Reduction and Environmental Improvement, Beijing Municipal Government, and College of Life Sciences, Capital Normal University, Beijing, China School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Shenzhen, China College of Computer and Information, Hohai University, Nanjing 210098, China State Key Laboratory of Heavy Oil Processing and Center for Bioengineering and Biotechnology, China University of Petroleum (East China), Qingdao 266580, China Modern Research Center for Traditional Chinese Medicine Beijing University of Chinese Medicine Beijing P. R. China Horizon Robotics, Haidian, China School of Pharmacy, Lanzhou University, Lanzhou 730000, P.R. China Key Laboratory of Industrial Ecology and Environmental Engineering (MOE), School of Environmental Science and Technology, Dalian University of Technology, Dalian 116024, China Key Laboratory of Tumor Molecular Biology in Binzhou Medical University, Department of Biochemistry and Molecular Biology, Binzhou Medical University, Yantai, ShanDong 264003, P.R.China Department of Emergency Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100016, China. Heilongjiang University of Traditional Chinese Medicine, Harbin, Heilongjiang, China Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (Ministry of Education); School of Pharmaceutical Sciences; Wuhan University; Wuhan 430071; P. R. China Key Laboratory of Horticultural Plant Biology of the Ministry of Education, College of Horticulture and Forestry Sciences, Huazhong Agricultural University, Wuhan 430070, China School of Pharmacy National and Local Joint Engineering Laboratory for Key Technology of Chinese Material Medica Quality Control Shenyang Pharmaceutical University Shenyang P.R. China College of Life Sciences, Zhejiang University, Hangzhou 310058, People's Republic of China Department of Pathology and Laboratory Medicine, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA 19104; Department of Respiratory Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (mainland) National Key Laboratory of Medical Molecular Biology, Department of Immunology, Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100005, China;; †National Key Laboratory of Medical Immunology, Institute of Immunology, Second Military Medical University, Shanghai 200433, China; and 1Centre for Molecular Microbiology and Infection, Department of Microbiology, Imperial College London, London SW7 2AZ, England, UK Institute for Advanced Study, Chengdu University, Chengdu 610106, China The Institute for Nutrition and Food Safety, Chinese Center for Disease Control and Prevention, Beijing 100050, China. Jilin Province Key Laboratory of Organic Functional Molecular Design and Synthesis, Department of Chemistry, Northeast Normal University State Key Laboratory of Medicinal Chemical Biology, Department of Cell Biology and Genetics, College of Life Sciences, Nankai University, Tianjin, China. Jilin Province Key Laboratory of Organic Functional Molecular Design & Synthesis Department of Chemistry Northeast Normal University Changchun 130024 China; Department State Key Laboratory of Organometallic Chemistry Institution Shanghai Institute of Organic Chemistry Chinese Academy of Sciences Shanghai 200032 China Email:yangyjfw@yahoo.com.cn. Key Laboratory of Endocrinology, Ministry of Health, Department of Endocrinology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, No. 1 Shuaifu Garden, Beijing 100730, China From the Intramural Research Program (C.Q., J.D., Q.Z., L.J.L.), Laboratory of Epidemiology and Population Sciences, National Institute on Aging, NIH, Bethesda, MD; Aging Research Center (C.Q.), Department of Neurobiology, Care Sciences and Society, Karolinska Institutet–Stockholm University, Sweden; Icelandic Heart Association (S.S., G.E., V.G.), Kopavogur; Division of Epidemiology and Clinical Research (D.E.F., M.F.C.), National Eye Institute, NIH, Bethesda, MD; Ophthalmology and Visual Sciences ... The Department of Surgery Room, Xi'an Daxing Hospital, Xi'an 710016, China. Zibo Disease Control and Prevention Center, Zibo, China Key Laboratory of Animal Physiology and Biochemistry, Ministry of Agriculture, College of Veterinary Medicine Nanjing Agricultural University Nanjing PR China Department of Infectious Diseases, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, P.R. China Department of General Medicine, Southwest Hospital, Army Medical University , Chongqing 400038 , China Guizhou University Medicine College, Guiyang 550025, Guizhou Province, China; Key Laboratory of Carcinogenesis and Translational Research (ministry of Education/Beijing), key Laboratory for Research and Evaluation of Radiopharmaceuticals (National Medical Products Administration) of Nuclear Medicine, Peking University Cancer Hospital & Institute, Beijing 100142, China College of Biomedical Information and Engineering, Hainan Medical University, Haikou 571199, China Department of Rehabilitation Medicine, The Affiliated Hospital of Guizhou Medical University, Guiyang, PR China School of Pharmacy Guangdong Provincial Key Laboratory of Advanced Drug Delivery Guangdong Provincial Engineering Center of Topical Precise Drug Delivery System Guangdong Pharmaceutical University Guangzhou 510006 China Department of Health and Exercise Science Colorado State University Fort Collins CO USA Ministry of Education Key Laboratory of Molecular and Cellular Biology, Hebei Collaboration Innovation Center for Cell Signaling and Environmental Adaptation, Hebei Key Laboratory of Molecular and Cellular Biology, College of Life Sciences, Hebei Normal University , Shijiazhuang 050024, China Key Laboratory of Science and Technology of Eco‐Textile Ministry of Education Jiangnan University Wuxi People's Republic of China Department of Anesthesiology, The First People’s Hospital of Lianyungang, 182 Tongguan Road, Lianyungang 222000, Jiangsu, China Ministry of Education; Taiyuan University of Technology Laboratory of Environmental Biomedicine, Hubei Key Laboratory of Genetic Regulation and Integrative Biology, School of Life Sciences, Central China Normal University, China National Key Laboratory of Medical Immunology and Institute of Immunology, Second Military Medical University, Shanghai, China Department of Surgery The First Affiliated Hospital of Zhengzhou University Zhengzhou Henan China School of Traditional Chinese Medicine Beijing University of Chinese Medicine Beijing China Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia; Department of Clinical Pharmacology The Second Hospital of Anhui Medical University Hefei China Department of Urology, Peking University First Hospital, Institute of Urology, Peking University, National Urological Cancer Center, Beijing 100034, China Department of Anesthesiology, Third Medical Center of Chinese PLA General Hospital, 69 Yongding Road, Haidian District, Beijing 100039, China College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou 310018, China Department of Oncology, The Central Hospital Of Enshi Tujia And Miao Autonomous Prefecture, Hubei, China Department of Pharmacy The Second Affiliated Hospital Army Medical University Chongqing China Department of Neurosurgery, The Fifth Medical Center of Chinese PLA General Hospital The 307th Hospital of the Chinese People's Liberation Army Academy of Military Medical Science Beijing China Department of Anesthesiology, School and Hospital of Stomatology China Medical University Shenyang People's Republic of China Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (MOE), School of Pharmaceutical Sciences, Wuhan University, Wuhan, 430071, China Department of Anesthesiology Tianjin Central Hospital of Gynecology and obstetrics 156 San Ma Road Tianjin 300191 China Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, Illinois State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences; University of Chinese Academy of Sciences, Beijing, China; University of Chinese Academy of Sciences, Beijing, China College of Pharmaceutical Sciences, Southwest University, Chongqing, China Department of Cardiology, China-Japan Union Hospital of Jilin University, Changchun, Jilin, China St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 1 Department of Pharmacy, Xinqiao Hospital, Army Medical University, Chongqing 400037, P.R. China Key Laboratory of Functional Inorganic Material Chemistry; Ministry of Education; School of Chemistry Engineering and Materials Science; Heilongjiang University; Harbin Department of Respiratory Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200123, P.R. China Department of Obstetrics Qingdao Municipal Hospital Qingdao China Department of Chemistry, University of Liverpool, Liverpool, L69 7ZD U.K. Department of Dermatologic Surgery, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, Department of Hematology, the First Affiliated Hospital of Harbin Medical University, No. 23, Youzheng Street, Nangang District, Harbin, Heilongjiang, China Department of Neonatology, Senior Department of Pediatrics, the Seventh Medical Center of Chinese PLA General Hospital, Beijing, China; National Engineering Laboratory for Birth Defects Prevention and Control of Key Technology, Beijing, China; Beijing Key Laboratory of Pediatric Organ Failure, Beijing, China Laboratory of Animal Cell Biology and Embryology, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China; Key Laboratory of Antibody Techniques of Ministry of Health, Nanjing Medical University, Nanjing, China Center for Reproductive Medicine Shandong University Jinan Shandong 250021 China; Key Laboratory of Reproductive Endocrinology of Ministry of Education Shandong University Jinan Shandong 250021 China Department of Cardiothoracic Surgery, Heart Center, Shanghai Children's Medical Center, Shanghai Jiaotong University School of Medicine , NO.1678 Dongfang Road, Pudong New District, Shanghai 200127, PR China Department of Neurosurgery, Beijing Tiantan Hospital Capital Medical University Beijing China; China National Clinical Research Center for Neurological Diseases Beijing China Email: zhangqian7208@163.com. Experimental Research Center, China Academy of Chinese Medical Sciences, Beijing 100700, China. Zhejiang Tiantong Forest Ecosystem National Observation and Research Station, Shanghai Key Lab for Urban Ecological Processes and Eco‐Restoration, School of Ecological and Environmental Sciences East China Normal University Shanghai China; State Key Laboratory of Systematic and Evolutionary Botany, Institute of Botany Chinese Academy of Sciences Beijing China Department of Critical Medicine, and Shenzhen Clinical Research Centre for Geriatrics Shenzhen People's Hospital First Affiliated Hospital of Southern University of Science and Technology Second Clinical Medicine College of Jinan University Shenzhen Guangdong China; Institute of Basic Integrative Medicine ，School of Traditional Chinese Medicine, and School of Pharmaceutical Sciences Southern Medical University Guangzhou Guangdong China; State Key Laboratory for Quality Ensurance and Sustainable Use of Dao‐di Herbs, Artemisinin Research Center, and Institute of Chinese Materia Medica China Academy of Chinese Medical Sciences Beijing China Zhejiang Provincial Key Laboratory of Medical Genetics, School of Laboratory Medicine and Life Sciences Wenzhou Medical University Wenzhou China Xi’an University of Posts and Telecommunications Center for High Pressure Science and Technology Advanced Research (HPSTAR), Beijing 100094, China State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory for Oral Biomedicine of Ministry of Education (KLOBM), School and Hospital of Stomatology, Wuhan University, Wuhan, People's Republic of China CAS Key Laboratory of Green Process & Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, PR China; University of Chinese Academy of Sciences, Beijing 100049, PR China Department of Clinical Pharmacology, The Second Hospital of Anhui Medical University, Hefei, Anhui, China Beijing National Laboratory for Molecular Sciences Key Laboratory of Organic Solids Institute of Chemistry Chinese Academy of Sciences Beijing 100190 P. R. China; University of Chinese Academy of Sciences Beijing 100049 P. R. China Department of Human Anatomy, Zunyi Medical College and Its Affiliated Hospital, Zunyi 563099, Guizhou Province, China. Departments of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, People's Republic of China; Shanghai Medical College, Fudan University, Shanghai, People's Republic of China Department of Dermatology, Shenzhen University General Hospital, Shenzhen University, Shenzhen, China; College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen, China; Shenzhen University Health Science Center, Shenzhen, China; Department of Dermatology, PLAGH Hainan Hospital Of PLA General Hospital, Sanya, China Department of Hematology, Peking Union Medical College Hospital & Chinese Academy of Medical Sciences, Beijing 100730, China. Department of Chemistry and Biochemistry, Concordia University, 7141 Sherbrooke St. W., Montreal, Quebec, Canada H4B 1R6 1School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China National Center for Protein Sciences Beijing, State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing 100850, China Guizhou University School of Medicine, Guiyang, 550025 Guizhou, People’s Republic of China College of Life Sciences; Fujian Agriculture and Forestry University; Fuzhou; China Clinical Pharmacy Department, Huashan Hospital, Fudan University, Shanghai, China Department of Plastic surgery, Tongren Hospital of Wuhan University (Wuhan Third Hospital) , Wuhan 430060 , China National Institute for Nutrition and Food Safety, Chinese Center for Disease Control and Prevention, Beijing 100050, China State Key Laboratory Base of Eco-Chemical Engineering, Taishan Scholar Advantage and Characteristic Discipline Team of Eco-Chemical Process and Technology, Qingdao University of Science and Technology, Qingdao 266042, China; College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, China College of Veterinary Medicine Gansu Agricultural University Lanzhou China Clinical Medical College, Guizhou Medical University, Guiyang 550004, China. National and Local Joint Engineering Laboratory for Key Technology of Chinese Material Medica Quality Control Shenyang Pharmaceutical University Shenyang China College of Chemistry, Chemical Engineering and Materials Science, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Shandong Provincial Key Laboratory of Clean Production of Fine Chemicals, Shandong Normal University, Jinan 250014, China The State Key Laboratory of Fluid Power and Mechatronic Systems, Zhejiang University, Hangzhou 310027, China; Faculty of Engineering and Environment, University of Northumbria, Newcastle upon Tyne NE1 8ST, U.K. Key Laboratory of Special Pathogens and Center for Emerging Infectious Diseases, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China Department of Occupational and Environmental Health the Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment School of Public Health Air Force Medical University Xi'an China Chongqing Key Laboratory of Biochemistry and Molecular Pharmacology College of Pharmacy Chongqing Medical University Yuzhong District Chongqing China Department of Hepatology and Gastroenterology, Tianjin Third Central Hospital Affiliated to Tianjin Medical University, Tianjin Key Laboratory of Artificial Cells, Tianjin, China State Key Laboratory of Clean and Efficient Coal Utilization, Taiyuan University of Technology, Taiyuan 030024, China Department of Chemistry and Environmental Science, New Jersey Institute of Technology, 323 Dr. Martin Luther King Boulevard, Newark, New Jersey 07102, United States Department of Cardiovascular Surgery Shandong Provincial Hospital affiliated to Shandong University Jinan China Key Laboratory of Green Chemistry & Technology; Ministry of Education; College of Chemistry; Sichuan University; Chengdu 610064 State Key Laboratory of Heavy Oil Processing and College of Chemistry and Chemical Engineering, China University of Petroleum (East China), Qingdao 266580, China State Key Laboratory of Chemical Resource Engineering & Beijing Laboratory of Biomedical Materials & Beijing Advanced Innovation Center for Soft Matter Science and Engineering Beijing University of Chemical Technology Beijing 100029 China Department of Molecular Biosciences, The University of Kansas, Lawrence, Kansas 66045 School of Life Science and Technology Xidian University Xi'an 710071 China Key Laboratory of Industrial Fermentation Microbiology, Ministry of Education, and‡College of Biotechnology, Tianjin University of Science and Technology, Tianjin 300457, People’s Republic of China Department of Hematology, First Affiliated Hospital, Harbin Medical University, Harbin, People’s Republic of China School of Sensing Science and Engineering School of Electronic Information and Electrical Engineering Shanghai Jiao Tong University 800 Dongchuan RD Shanghai 200240 China Department of Chemistry Xi'an-Jiaotong Liverpool University 215123 Suzhou China; Department of Chemistry University of Liverpool Liverpool L697ZD UK State Key Laboratory of Geomechanics and Geotechnical Engineering, Institute of Rock and Soil Mechanics, Chinese Academy of Sciences, Wuhan, China School of Computer Science Zhongyuan University of Technology Zhengzhou 450007 China Key Laboratory of Green Processing and Functional New Textile Materials of Ministry of Education, Wuhan Textile University, Wuhan, China Polymeric and Soft Materials Laboratory, School of Chemical Engineering, Advanced Institute of Materials Science, Changchun University of Technology, Changchun 130012, P. R. China Department of Biochemistry and Molecular Biology, Graduate Program in Genes and Development, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030; and Division of Hematology/Oncology, The Children's Hospital and Dana–Farber Cancer Institute and Howard Hughes Medical Institute, Boston, MA 02115 Department of Chemistry, Northeast Normal University, 5268 Renmin Street, Changchun 130024, P. R. China Key Laboratory of Endocrinology of National Health Commission, Diabetes Research Center of Chinese Academy of Medical Sciences, Department of Endocrinology, Translational Medicine Center, Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing People's Republic of China Genetics, University of North Carolina, Chapel Hill, NC 27599 Department of Psychology University of Leeds Leeds UK Qingshan District Center for Disease Control and Prevention, 4# Yangang Road, Wuhan 430070, China Department of Epidemiology and Biostatistics, School of Public Health Anhui Medical University Hefei Anhui China Institute of Nano Biomedicine and Engineering; Shanghai Engineering Research Center for Intelligent diagnosis and treatment instrument; Department of Instrument Science and Engineering; School of Electronic Information and Electrical Engineering; Shanghai Jiao Tong University Department of Environmental Science and Engineering, Huaqiao University, Xiamen 361021, China; Fujian Provincial Research Center of Industrial Wastewater Biochemical Treatment (Huaqiao University), Xiamen 361021, China Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD; Central Laboratory, School of Stomatology, Peking University, Beijing 100081, China Department of Sports Medicine, Affiliated Zhongshan Hospital of Dalian University, Dalian, Liaoning, China (mainland) Key Laboratory of Functional Polymer Materials of Ministry of Education, Institute of Polymer Chemistry, and ‡Collaborative Innovation Center of Chemical Science and Engineering, Nankai University, Tianjin 300071, China School of Microelectronics, Xidian University, Xi’an 710071, China; State Key Discipline Laboratory of Wide Bandgap Semiconductor Technologies, Xidian University, Xi’an 710071, China Yaneng Bioscience (Shenzhen) Co., Ltd. Liuxian 1st Road, Baoan District, Shenzhen 518102, China. Department of Pharmacy, The Affiliated Bozhou Hospital of Anhui Medical University, Bozhou, Anhui 236000, P.R. China Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Rd, Wuhan 430030, China; Hubei Key Laboratory of Food Nutrition and Safety, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Rd, Wuhan 430030, China Department of Urology, Peking University First Hospital and Institute of Urology, National Research Center for Genitourinary Oncology, Beijing, China College of Vehicle and Traffic Engineering, Henan University of Science and Technology, Luoyang 471023, China College of Life Science, Nantong University, Nantong, Jiangsu 226019, China Department of Biochemistry and Molecular Biology Tulane University School of Medicine New Orleans 70112 USA Laboratory for the Modeling of Biological and Socio-Technical Systems, Northeastern University, Boston, MA, USA School of Energy and Power Engineering Key Laboratory of Ocean Energy Utilization and Energy Conservation of Ministry of Education Dalian University of Technology Dalian 116024 China School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325000, China. tsh006@163.com. School of Chemistry and Materials Science, Jiangsu Normal University, Xuzhou 221116, China Department of Nutrition and Food Hygiene, School of Public Health, China Medical University, Shenyang, China Department of Geriatric Medicine, Shenzhen People's Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology) , Shenzhen 518020, China; Artemisinin Research Center, and Institute of Chinese Materia Medica, Chinese Academy of Chinese Medical Sciences , Beijing 100700, China; School of Traditional Chinese Medicine, Southern Medical University , Guangzhou 510515, China Key Laboratory of Functional Organic Molecule Design & Synthesis of Jilin Province, Department of Chemistry, Northeast Normal University, Changchun, 130024, China Department of Medicine/Division of Cancer Prevention, Stony Brook University, Stony Brook, NY 11794, USA Department of Pathology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China Department of Neurology Xuanwu Hospital Capital Medical University Beijing China Department of Pharmacy First Affiliated Hospital of Shantou University Medical College Shantou China Key Laboratory of Agro-Environment in the Tropics, Ministry of Agriculture and Rural Affairs; Guangdong Provincial Key Laboratory of Eco-Circular Agriculture; Guangdong Engineering Research Centre for Modern Eco-Agriculture; College of Natural Resources and Environment, South China Agricultural University, Guangzhou 510642, People’s Republic of China Suzhou Key Laboratory of Nanotechnology and Biomedicine, Institute of Functional Nano and Soft Materials (FUNSOM), and Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou 215123, China Neonatal Intensive Care Unit The First Affiliated Hospital of Zhengzhou University Zhengzhou China a Department of Medicinal Chemistry , School of Pharmacy, Fudan University , Shanghai, China School of Materials and Chemical Engineering, Hubei University of Technology Joint International Research Laboratory of Water and Nutrient in Crops Center for Plant Water‐Use and Nutrition Regulation and College of Resource and Environment, Fujian Agriculture and Forestry University Jinshan Fuzhou China Department of Respiratory Medicine The Affiliated Brain Hospital of Nanjing Medical University Nanjing China; Endoscopic Center of Nanjing Brain Hospital Nanjing China Department of Hematology Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University Nanjing China Academy for Advanced Interdisciplinary Studies Peking University Beijing China School of Perfume and Aroma Technology Shanghai Institute of Technology Shanghai PR China The Center of New Energy Materials and Technology; School of Materials Science and Engineering; Southwest Petroleum University; Chengdu 610500; China Institute of Nano Biomedicine and Engineering Shanghai Engineering Research Center for Intelligent Diagnosis and Treatment Instrument Department of Instrument Science and Engineering School of Electronic Information and Electrical Engineering Shanghai Jiao Tong University 800 Dongchuan RD Shanghai 200240 P. R. China; National Center for Translational Medicine Collaborative Innovational Center for System Biology Shanghai Jiao Tong University 800 Dongchuan Road Shanghai 200240 P. R. China Key Laboratory of Semiconductor Materials Science, Institute of Semiconductors, Chinese Academy of Sciences, Beijing 100083, P. R. China.; Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, Beijing 100049, P. R. China. The Affiliated Hospital of Qingdao University & The Biomedical Sciences Institute of Qingdao University (Qingdao Branch of SJTU Bio-X Institutes), Qingdao University, Qingdao, China Department of Cardiovascular Surgery, The Affiliated Hospital of Qingdao University, Qingdao, China. School of Chemistry and Chemical Engineering Yangzhou University Yangzhou 225009 P. R. China Department of Applied Chemistry, Xi’an University of Technology, Xi’an 710048, China Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai, China National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest China, Key Laboratory of the Ministry of Education for Medicinal Resources and Natural Pharmaceutical Chemistry, College of Life Sciences, Shaanxi Normal University, Xi’an, Shaanxi, China State Key Laboratory of Millimeter Waves, Southeast University, Nanjing 210096, China Center for Genome Analysis ABLife Inc. Wuhan China Department of Hematology and Hematopoietic Stem Cell Transplantation Center, General Hospital of the Chinese People’s Liberation Army Western Theatre, Chengdu, SiChuan, China Central Laboratory, Peking University School and Hospital of Stomatology, Beijing 100081, China Department of Prosthetic Dentistry, Affiliated Hospital of Medical College, Qingdao University, Shandong Province, China. Joint International Research Laboratory of Water and Nutrient in Crop, College of Resources and Environment Fujian Agriculture and Forestry University Fuzhou 350002 China Center for Studies of Education and Psychology of Ethnic Minorities in Southwest Area, Southwest University, Chongqing, China.; Faculty of Education, Southwest University, Chongqing, China. 3Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania. China Research Institute of Daily Chemical Industry 34# Wenyuan Str. 030001 Taiyuan Shanxi People's Republic of China Beijing Xiaoying Technology Co., Ltd Beijing China Key Laboratory of Endocrinology, Translational Medicine Center, Ministry of Health, Department of Endocrinology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China Department of Anesthesiology The Third Affiliated Hospital of Sun Yat‐sen University Guangzhou China Department of Materials Science and Engineering, Harbin Institute of Technology, 518055 Shenzhen, People’s Republic of China;; Institute of Materials Genome & Big Data, Harbin Institute of Technology, 518055 Shenzhen, People’s Republic of China; Department of Epidemiology and Health Statistics, Public Health of Anhui Medical University, Hefei, China; Contributed equally School of Materials and Chemistry University of Shanghai for Science and Technology Shanghai People's Republic of China; Shanghai Institute of Organic Chemistry Chinese Academy of Sciences Shanghai People's Republic of China Department of Pharmacy, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School Nanjing Medical University Suzhou Jiangsu China Beijing Key Laboratory of Materials Utilization of Nonmetallic Minerals and Solid Wastes; National Laboratory of Mineral Materials; School of Materials Science and Technology; China University of Geosciences; Beijing, P.R. China Key Laboratory of Endocrinology, Ministry of Health, Department of Endocrinology Peking Union Medical College HospitalPeking Union Medical CollegeChinese Academy of Medical Sciences Beijing China Key Laboratory of Power Batteries and Relative Materials, Jiangxi University of Science and Technology, Ganzhou 341000, Jiangxi, China Department of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital, Diabetes Research Center of Chinese Academy of Medical Sciences and Peking Union Medical College, No. 1 Shuaifuyuan, Wangfujing Street, Dongcheng District, Beijing 100730, China Department of Urology, Peking University First Hospital, Xicheng, Beijing, China; Institute of Urology, Peking University, National Urological Cancer Center, Beijing, China Clinical Research Center for Anesthesiology and Perioperative Medicine Tongji University Shanghai China; Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation Shanghai China; Translational Research Institute of Brain and Brain‐Like Intelligence, Shanghai Fourth People's Hospital, School of Medicine Tongji University Shanghai China; Department of Anesthesiology and Perioperative Medicine, Shanghai Fourth People's Hospital, School of Medicine Tongji University Shanghai China Department of Obstetrics and Gynecology, Shandong Provincial Hospital Affiliated to Shandong University, No. 324 Jingwu Road, Jinan 250021, China The State Key Laboratory of Fluid Power and Mechatronic Systems, Zhejiang University, Hangzhou 310027, China; Faculty of Engineering and Environment, University of Northumbria, Tyne NE1 8ST, U.K. Department of Science and Technology, The Affiliated Tumor Hospital of Xinjiang Medical University, Urumqi 830011, China From the Department of Nutrition and Food Hygiene, School of Public Health, China Medical University, Shenyang, China. Department of Dermatology, the First Hospital of China Medical University, Shenyang, China Department of Neurology, Hubei No. 3 People’s Hospital of Jianghan University , Wuhan , Hubei , China Department of Emergency, Anzhen Hospital, Capital Medical University 1. State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China. Department of Materials Science and Engineering and Institute of Materials Genome & Big Data Harbin Institute of Technology Shenzhen 518055 P. R. China Department of Urology, Peking University First Hospital and Institute of Urology, Beijing 100034, China; and Department of Neurology, The First Affiliated Hospital of Soochow University, Suzhou City 215006, China; Institute of Neuroscience, Soochow University, Suzhou City 215123, China Department of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, P. R. China College of Chemical Engineering, Huaqiao University, Xiamen, China School of Pharmacy, Lanzhou University, Lanzhou 730000, P. R. China Department of Pharmacy, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Suzhou, Jiangsu, China Shandong Provincial Hospital affiliated to Shandong University, Jinan, Shandong, China BioTechnology Institute, University of Minnesota St. Paul Minnesota USA Key Laboratory of Genetics & Molecular Medicine of Shenzhen Shenzhen Center for Disease Control and Prevention Shenzhen China School of Chemistry and Chemical Engineering Yangzhou University Yangzhou Jiangsu 225009 P. R. China Sino-German Joint Research Lab for Space Biomaterials and Translational Technology; School of Life Sciences; Northwestern Polytechnical University; Xi’an; China School of Chemistry and Chemical Engineering Yangzhou University Yangzhou 225009 China National Institute for Nutrition and Health (Q.Z.), Chinese Center for Disease Control and Prevention, Beijing 100050, China Fujian-Taiwan Science and Technology Cooperation Base of Biomedical Materials and Tissue Engineering, Engineering Research Center of Industrial Biocatalysis, Fujian Provincial Key Laboratory of Advanced Materials Oriented Chemical Engineering, College of Chemistry and Materials Science, Fujian Normal University, Fuzhou 350007, P. R. China Department of Encephalopathy, Gansu Provincial Hospital of TCM, Lanzhou, Gansu 730050, P.R. China School of Materials and Chemistry University of Shanghai for Science and Technology Shanghai People's Republic of China Department of Ophthalmology, Sichuan Provincial People’s Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu City, Sichuan Province, China Department of Respiratory Medicine, East Hospital, Tongji University School of Medicine, Shanghai 200123, China; Department of Respiratory Medicine, Shanghai East Clinical Medical College, Nanjing Medical University, Shanghai 200123, China Laboratory of Host Defenses 1 , 2 , 3 , and 4; Laboratory of Systems Biology 1 , 2 , 3 , and 4; Laboratory of Immunology 1 , 2 , 3 , and 4; Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1 , 2 , 3 , and 4 Transplantation Biology Research Division State Key Laboratory of Membrane Biology, Institute of ZoologyChinese Academy of Sciences Beijing China Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University, 24 Tong Jia Xiang, 210009 Nanjing, China College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, China Physikalische und Theoretische Chemie, Freie Universität Berlin, D-14195 Berlin, Germany; Department of Nephrology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Paris, France;; Imagine Institute, Paris, France; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA; New Materials and Green Manufacturing Talent Introduction and Innovation Demonstration Base School of Materials and Chemical Engineering Hubei University of Technology Wuhan 430068 P. R. China Key Laboratory for Organic Electronics and Information Displays and Jiangsu Key Laboratory for Biosensors, Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing University of Posts and Telecommunications, Nanjing 210023, China College of Veterinary Medicine, Gansu Agricultural University, Lanzhou 730070, China Dept. of Prosthodontics and Implantology, Stomatology Hospital of Guangzhou Medical University, Guangzhou 510140, China. Laboratory of Drosophila* Research School of Life Sciences Faculty of Science The Chinese University of Hong Kong Shatin, N.T. Hong Kong SAR China; Biochemistry Program School of Life Sciences Faculty of Science The Chinese University of Hong Kong Shatin, N.T. Hong Kong SAR China Engineering Research Center for Production Mechanization of Oasis Special Economic Crop, Ministry of Education, Shihezi 832003, China Key Laboratory of Antibody Technique of National Health Commission, Nanjing Medical University, Nanjing 211166, China Department of Medical Psychology and Ethics, School of Basic Medicine, Shandong University, Jinan City, Shandong Province, PR China. Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, National Clinical Research Center for Digestive Diseases, Beijing Digestive Disease Center, Faculty of Gastroenterology of Capital Medical University, Beijing Key Laboratory for Precancerous Lesion of Digestive Diseases, Beijing, China Department of Biochemistry and Molecular Biology and Tulane Center for Aging Tulane University Health Sciences Center New Orleans LA 70112 USA Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, National Clinical Research Center for Digestive Disease, Beijing Digestive Disease Center, Beijing Key Laboratory for Precancerous Lesion of Digestive Disease, Beijing 100050, PR China Department of Chemistry Northeast Normal University 5268 Renmin Rd Changchun Jilin 130024 China Department of Urology, Fuxing Hospital Affiliated to Capital University of Medical Science, Beijing 100038, China. rrpyzq@yahoo.com.cn Key Lab of Ecological Environment Science and Technology, First Institute of Oceanography Ministry of Natural Resources Qingdao China Key Lab of Bioelectrochemistry & Environmental Analysis of Gansu, College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070, China Carbon Neutralization Research Institute, School of New Energy and Materials, Southwest Petroleum University, Chengdu, Sichuan Province 610500, China Beijing University of Technology Clinical Pharmacy Department, Huashan Hospital, Fudan University, Shanghai P. R. China Key Laboratory of Aging and Cancer Biology of Zhejiang Province Hangzhou Normal University School of Basic Medical Sciences Hangzhou China Department of Cancer Research, The General Hospital and Basic Medical School, Ningxia Medical University, Yinchuan, China. Department of Gerontology, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China College of Food Science and Engineering, Jilin University, Changchun, Jilin 130062, People's Republic of China Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck & Co., Incorporated, West Point, Pennsylvania 19486, United States Department of infectious diseases, Affiliated Hospital of Southwest Medical University, Luzhou, China School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, P.R. China Department of Materials Science and Engineering Harbin Institute of Technology (Shenzhen) Shenzhen 518055 China Department of Medical Oncology, Affiliated Hospital of Hebei University, Hebei Key Laboratory of Cancer Radiotherapy and Chemotherapy, Baoding, Hebei 071000, China National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest of China, Key Laboratory of the Ministry of Education for Medicinal Resources and Natural Pharmaceutical Chemistry, College of Life Sciences, Shaanxi Normal University, Xi’an 710062, China National Key Laboratory of Molecular Biology and Department of Immunology, Chinese Academy of Medical Sciences, Beijing 100730, China; and Research Institute for Microbial Diseases, Osaka University, Suita, Osaka 5650871, Japan; Department of Oral and Maxillofacial Surgery, The Affiliated Hospital of Qingdao University, School of Stomatology Qingdao University Qingdao China Ophthalmology Department, Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu City, Sichuan Province 610072, People’s Republic of China Department of Pharmacy, Guilin Medical University, Guilin, PR China Department of Materials Science and Engineering Harbin Institute of Technology Shenzhen Guangdong 518055 China Department of Prosthodontics, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266000, P.R. China National Key Laboratory of Plant Molecular Genetics, CAS Centre for Excellence in Molecular Plant Sciences, Shanghai Institute of Plant Physiology and Ecology Chinese Academy of Sciences Shanghai 200032 China Jilin Province Key Laboratory of Organic Functional Molecular Design and Synthesis, Department of Chemistry, Northeast Normal University; State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences Department of Hepatobiliary, Pancreatic and Splenic Surgery, The Affiliated Hospital of Inner Mongolia Medical University, Huhhot, China PR Department of Pathology, Binzhou Medical University Hospital, Binzhou Medical University, Binzhou 256603, China Department of Nuclear Medicine, Shanghai Tenth People, s Hospital, Tongji University School of Medicine, Shanghai 200072, China Department of Materials Science and Engineering National University of Singapore 9 Engineering drive 1 Singapore 117574 Singapore Division of Nephrology, Department of Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China Polymeric and Soft Materials Laboratory, School of Chemical Engineering and Advanced Institute of Materials Science, Changchun University of Technology, Changchun 130012, China From the Department of Radiology (B.S., M.A.v.B.), Department of Gerontology and Geriatrics (B.S.), Leiden University Medical Center, The Netherlands; Leiden Institute for Brain and Cognition, Leiden University, The Netherlands (M.A.v.B.); Icelandic Heart Association, Reykjavik (S.S., V.G.); Intramural Research Program, National Institute on Ageing (Q.Z., O.M., T.B.H., L.J.L.) and Cardiovascular and Pulmonary Branch, National Heart, Lung, and Blood Institute (A.E.A.), National Institutes of Health,... Program in Emerging Infectious Diseases, Duke-NUS Graduate Medical School, Singapore; Center for Bioimaging Sciences, National University of Singapore, Singapore Digestive Department China‐Japan Union Hospital of Jilin University Changchun China Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA. State Key Laboratory of Membrane Biology, Institute of Zoology Chinese Academy of Sciences Beijing China; University of Chinese Academy of Sciences Beijing China School of Basic Medical Sciences Chengdu Medical College Chengdu China State Key Laboratory of Hybrid Rice College of Life Sciences, Wuhan University Wuhan 430072 China College of Veterinary Medicine, Northwest A&F University, Xianyang 712100, China; State Key Laboratory for Biology of Livestock, Northwest A&F University, Xianyang 712100, China 4Department of Urology, Peking University First Hospital & Institute of Urology, Peking University; Department of Orthopaedic Surgery Wuxi Ninth People's Hospital Affiliated to Soochow University Wuxi China Department of Chemistry and Biochemistry, University of Maryland, College Park 20742, Maryland, United States Department of Cancer Epidemiology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. Division of Advanced Manufacturing, Graduate School at Shenzhen, Tsinghua University, 518055, Shenzhen, China Department of Gynecological Oncology Ward, Gansu Provincial Cancer Hospital, Lanzhou, Gansu 730050, P.R. China Key Laboratory of Endocrinology, Ministry of Health, Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China The Sixth Affiliated Hospital of Shenzhen University and Huazhong University of Science and Technology Union Shenzhen Hospital Shenzhen China Department of Biochemistry and Molecular Biology, Tulane University Health Science Center, 1430 Tulane Ave, New Orleans LA 70112, U.S.A. Beijing Key Laboratory of Ornamental Plants Germplasm Innovation and Molecular Breeding, National Engineering Research Center for Floriculture, College of Landscape Architecture, Beijing Laboratory of Urban and Rural Ecological Environment Beijing Forestry University Beijing PR China; Key Laboratory of Genetics and Breeding in Forest Trees and Ornamental Plants, Ministry of Education Beijing Forestry University Beijing PR China 3Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania. Key Laboratory of Bio-Resources and Eco-Environment of Ministry of Education, State Key Laboratory of Hydraulics and Mountain River Engineering, College of Life Sciences, Sichuan University, Chengdu, China 8Genelux Corp., San Diego Science Center, San Diego, California; and; 9Institute for Biochemistry, Biocenter and Institute for Molecular Infectious Biology and Key Laboratory of Pesticide & Chemical Biology of Ministry of Education, Institute of Environmental and Applied Chemistry, Engineering Research Center of Photoenergy Utilization for Pollution Control and Carbon Reduction, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, P. R. China Department of Ophthalmology, the Second Affiliated Hospital of Nanchang University, Nanchang 330000, Jiangxi Province, China. Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing 100084, China a College of Water Conservancy Engineering, Tianjin Agricultural University, Tianjin 300384, China Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, China; China National Clinical Research Center for Neurological Diseases, China; Center of Stroke, Beijing Institute for Brain Disorders, China; Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, China; Beijing Translational Engineering Center for 3D Printer in Clinical Neuroscience, China Laboratory Animal Center Chongqing Medical University Chongqing China Department of General Surgery The First Affiliated Hospital of Nanjing Medical University Nanjing China Hubei Provincial Key Laboratory of Green Materials for Light Industry, Hubei University of Technology, Wuhan 430068, China; New Materials and Green Manufacturing Talent Introduction and Innovation Demonstration Base, Hubei University of Technology, Wuhan 430068, China Food Safety Laboratory; Ocean University of China; Qingdao 266003 People's Republic of China Department of Gastroenterology, The Third Affiliated Hospital of CQMU, ChongQing, China State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Institutes of Brain Science Department of Translational Neuroscience Jing'an District Centre Hospital of Shanghai Fudan University Shanghai China Department of Psychology, Education College, Shanghai Normal University, Shanghai 200234, China Institut für Chemie und Biochemie Freie Universität Berlin Takustr. 3 14195 Berlin Germany Jilin Province Key Laboratory of Organic Functional Molecular Design & Synthesis, Department of Chemistry, Northeast Normal University, Changchun 130024, China Chemical and Environmental Engineering Institute, Dalian University, 11662 Dalian, China; Environmental Micro Total Analysis Lab, Dalian University, 11662 Dalian, China Department of Colorectal Cancer Surgery, the Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, People's Republic of China. Colorectal Cancer Institute of Harbin Medical University, Harbin, Heilongjiang, People's Republic of China. Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China Department of Chemistry, Northeast Normal University, Changchun, 130024, China Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100037, China Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, 450001, Henan Province, People's Republic of China School of Nursing, Lanzhou University Department of Clinical Pharmacology Affiliated Hospital of Nanjing University of Chinese Medicine Jiangsu Provincial Hospital of Traditional Chinese Medicine Nanjing P. R. China Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, People’s Republic of China School of Chemistry and Chemical Engineering, Henan Key Laboratory of Organic Functional Molecule and Drug Innovation Key Laboratory of Green Chemical Media and Reactions of Ministry of Education Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals Henan Normal University Xinxiang 453007 China Department of Cardiology, Xuzhou Central Hospital, Xuzhou, People Republic of China Key Laboratory of Optic-electric Sensing and Analytical Chemistry for Life Science, MOE, Shandong Key Laboratory of Biochemical Analysis, Key Laboratory of Analytical Chemistry for Life Science in Universities of Shandong, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, P. R. China Department of Oral and Maxillofacial Surgery the Affiliated Hospital of Qingdao University Qingdao China; School of Stomatology of Qingdao University Qingdao China School of Civil Engineering & Architecture, Wuhan University of Technology, Wuhan 430070, China Department of Pathology, Binzhou Medical University Hospital, Binzhou Medical University, Binzhou, Province, China Key Laboratory of Bio-Resources and Eco-Environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, China Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, People’s Republic of China Department of Neurology The Fifth Affiliated Hospital of Guangxi Medical University and The First People's Hospital of Nanning Nanning China Department of General Surgery, The Affiliated Cancer Hospital of Nanjing Medical University & Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research, Nanjing 210009, P.R. China Department of Respiratory, Affiliated Hospital of Nanjing Medical University, Changzhou Second People's Hospital Changzhou 213003, China. National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, Wuhan, China Key Laboratory of Endocrinology Translational Medicine Center Ministry of Health Department of Endocrinology Peking Union Medical College Hospital Diabetes Research Center of Chinese Academy of Medical Sciences & Peking Union Medical College Beijing China Beijing Tiantan Hospital, Capital Medical University, Beijing, China; China National Clinical Research Center for Neurological Diseases, Beijing, China; Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China Bristol-Myers Squibb Research & Development, 700 Bay Road, Redwood City, California 94063, United States Key Laboratory of Fluid and Power Machinery; Ministry of Education; School of Energy and Power Engineering; Xihua University; Chengdu 610039 Institute of Geographic Sciences and Natural Resources Research; Chinese Academy of Sciences; Beijing China Division of Applied Mathematics, Brown University, Providence, RI, USA Guangdong Provincial Key Laboratory of Silviculture, Protection and Utilization, Guangzhou 510520, China; Guangdong Academy of Forestry, Guangzhou 510520, China Departments of aPathology and Laboratory Medicine and Shenzhen Key Laboratory of Advanced Materials, Department of Materials Science and Engineering, Harbin Institute of Technology Shenzhen Graduate School, Shenzhen 518055, China Department of Dermatology Peking University Third Hospital Beijing China Department of Chemistry and Biochemistry, Utah State University, Logan, Utah 84322-0300, United States Department of Infectious Diseases, Henan Provincial People's Hospital, Zhengzhou, Henan 450000, P.R. China State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Centre for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China. 1Department of Medicine/Cancer Prevention, Stony Brook University, Stony Brook, New York. Department of Epidemiology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China Department of Preventive Medicine & Chongqing Engineering Research Center of Pharmaceutical Sciences, Chongqing Medical and Pharmaceutical College, Chongqing, China MOE Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology, Department of Chemistry, Tsinghua University, Qing Hua Yuan, Haidian District, Beijing 100084, China From the Departments of Medicine and Biostatistics and Medical Informatics, University of Wisconsin, Madison, WI; Hospital K, Hanoi, Vietnam; People’s Hospital of Haimen City, Haimen, Jiangsu, China; and Department of Pathology, Baylor College of Medicine, Houston, TX. College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, China Key Laboratory of Sensor Analysis of Tumor Marker; Ministry of Education; Shandong Key Laboratory of Biochemical Analysis; Key Laboratory of Analytical Chemistry for Life Science in Universities of Shandong; College of Chemistry and Molecular Engineering; Qingdao University of Science and Technology; Qingdao 266042; P. R. China Department of Ophthalmology, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, P. R. China State Key Laboratory for Biology of Plant Diseases and Insect Pests Institute of Plant Protection Chinese Academy of Agricultural Sciences Beijing China Department of Infectious Disease, the First Affiliated Hospital of Nanjing Medical University , Nanjing, Jiangsu , China College of Pharmacy, Dali University, Dali, China Key Laboratory of Endocrinology, Ministry of Health, Department of Endocrinology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China School of Information and Electrical Engineering, China University of Mining and Technology, Xuzhou, Jiangsu 221116, China Center of Hematology, The First Affiliated Hospital of Nanchang University, Nanchang, China; Institute of Hematology, Academy of Clinical Medicine of Jiangxi Province, Nanchang, China; National Clinical Research Sub-Center for Blood Diseases, Jiangxi Clinical Research Center of Hematology, Nanchang, China The Affiliated Hospital of Qingdao University and Biomedical Sciences Institute of Qingdao University (Qingdao Branch of SJTU Bio-X Institutes), Qingdao University, Qingdao, China Regeneron Pharmaceuticals, 777 Old Saw Mill River Rd, Tarrytown, New York 10591, United States Qingshan District Center for Disease Control and Prevention, 4# Yangang Road, Wuhan, 430080, China Key Laboratory of Functional Organic Molecule Design & Synthesis of Jilin Province, Department of Chemistry, Northeast Normal University, 5268 Renmin Rd, Changchun, Jilin 130024, China Department of Genetics and Cell Biology, Frontiers Science Center for Cell Responses, Tianjin Key Laboratory of Protein Sciences, College of Life Sciences, Nankai University , Tianjin, 300071 , People’s Republic of China State Key Laboratory of Efficient Production of Forest Resources, Beijing Key Laboratory of Ornamental Plants Germplasm Innovation and Molecular Breeding, National Engineering Research Center for Floriculture, Beijing Laboratory of Urban and Rural Ecological Environment, Key Laboratory of Genetics and Breeding in Forest Trees and Ornamental Plants of Ministry of Education, School of Landscape Architecture, Beijing Forestry University, Beijing 100083, China Department of Endocrinology Qilu Hospital Cheeloo College of Medicine Shandong University Jinan China; Institute of Endocrine and Metabolic Diseases of Shandong University Jinan China; Key Laboratory of Endocrine and Metabolic Diseases Shandong Province medicine and health Jinan China Department of Cardiovascular Surgery, Shandong Provincial Hospital Affiliated to Shandong First MedicaDepartment of Cardiovascular Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, Chinal University, Jinan, Shandong, China. Department of Dermatology Xijing Hospital Fourth Military Medical University Xi'an Shaanxi China Department of Ultrasound Xi'an Children's Hospital Xi'an China Department of Biotherapy, Eastern Hepatobiliary Surgery Hospital, The Second Military Medical University, Shanghai, China Biologics Discovery California Bristol‐Myers Squibb Redwood City CA United States Department of Oral and Maxillofacial Surgery, Nanjing Stomatological Hospital Medical School of Nanjing University Nanjing China College of Chemistry, Chemical Engineering and Resource Utilization, Northeast Forestry University, Harbin, 150040, Heilongjiang, China Laboratory for the Modeling of Biological and Socio-technical Systems, Northeastern University 2 , Boston, Massachusetts 02115, USA Department of Environmental and Occupational Health West China School of Public Health, West China Fourth Hospital Sichuan University Chengdu Sichuan China From the Vascular Biology Center and Department of Pharmacology (Q.Z., J.E.C., D.J., J.D.C., D.F.), Medical College of Georgia, Augusta; and Department of Pharmacology and Molecular Cardiobiology Division (W.C.S.), Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, Conn. HLA Typing Laboratory Yinfeng Gene Technology Co. Ltd. Jinan China Department of Intensive Care Medicine, Affiliated Hospital of Guizhou Medical University, Guiyang, China Key Laboratory of Power Battery and Materials Faculty of Materials Metallurgy and Chemistry Jiangxi University of Science and Technology Ganzhou 341000 China College of Information and Electrical Engineering, China Agricultural University, Beijing 100083, China National Institute for Nutrition and Food Safety, Chinese Center for Diseases Control and Prevention, Beijing 100050, China. Department of Plastic and Reconstructive Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China Co-Innovation Center of Efficient Processing and Utilization of Forest Resources International Innovation Center for Forest Chemicals and Materials College of Science Nanjing Forestry University Nanjing 210037 PR China HangZhou GuSheng Biotechnology Co. Ltd HangZhou 311108 China Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-4283; and The MOE Key Laboratory for Standardization of Chinese Medicines and The SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, China Department of Immunology, Center for Immunotherapy, Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100005, China;,; National Key Laboratory of Medical Immunology, Institute of Immunology, Navy Military Medical University, Shanghai 200433, China Key Laboratory of Strongly-Coupled Quantum Matter Physics, Chinese Academy of Sciences, School of Physical Sciences, University of Science and Technology of China, Hefei 230026, PR China Department of Neurosurgery, The Fifth Medical Centre Chinese PLA General Hospital Beijing China Key Laboratory of Plant Gene Resources and Biotechnology for Carbon Reduction and Environmental Improvement, Beijing Municipal Government, and College of Life Sciences Capital Normal University Beijing 100048 China NCQA, Washington, DC, USA Rehabilitation Treatment, Department of Speech Therapy, Shanghai Second Rehabilitation Hospital, Shanghai, China (mainland) School of Life and Environmental Sciences, Guilin University of Electronic Technology, Guilin 541004, China Department of Biology, Pennsylvania State University, University Park, Pennsylvania 16802, United States Chinese Academy of Agricultural Sciences Lanzhou Institute of Husbandry and Pharmaceutical Science, Lanzhou, China School of Materials, Sun Yat-sen University, Shenzhen 518107, China Endoscopic Center of Nanjing Chest Hospital, Nanjing, 210009, Jiangsu, China; Clinical Center of Nanjing Respiratory Diseases and Imaging, Nanjing, 210009, China; Department of Respiratory Medicine, The Affiliated Hospital of Southeast University, Nanjing, Jiangsu 210009, China Center for Reproductive Medicine, Shandong University, Jinan, Shandong, China Department of Chemistry Jilin Province Key Laboratory of Organic Functional Molecular Design & Synthesis Northeast Normal University Changchun 130024 China Key Laboratory of Environment and Health, Ministry of Education, Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei China Purdue University West Lafayette USA Taian City Central Hospital, Taian, 271000 Shandong Province, China Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA; and MOE Key Laboratory of Bioorganic Phosphorous Chemistry and Chemical Biology Department of Chemistry Tsinghua University Beijing 100084 China School of Public Health, Nanchang University, Nanchang, China State Key Laboratory and Institute of Elemento-Organic Chemistry and Centre for Nanoscale Science and Technology, Institute of Polymer Chemistry and Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), College of Chemistry, Nankai University, Tianjin 300071, China Center for Translational Cancer Research; Institute of Biosciences and Technology; Department of Medical Physiology; College of Medicine; Texas A&M University Hefei National Laboratory for Physical Sciences at the Microscale, University of Science and Technology of China, Hefei, Anhui 230026, China; Department of Applied Chemistry, Hefei Science Center of Chinese Academy of Sciences, University of Science and Technology of China, Hefei, Anhui 230026, China Key Laboratory of Northwest Resource; Environment and Ecology; MOE; Xi'an University of Architecture and Technology; Xi'an 710055 Brian M. Slomovitz, Yunyun Jiang, Melinda S. Yates, Pamela T. Soliman, Taren Johnston, Charles Levenback, Qian Zhang, Kari Ring, Mark F. Munsell, David M. Gershenson, Karen H. Lu, and Robert L. Coleman, The University of Texas MD Anderson Cancer Center, Houston, TX; Brian M. Slomovitz and Maureen Nowakowski, Morristown Medical Center, Morristown, NJ; and Brian M. Slomovitz, Sylvester Comprehensive Cancer Center, University of Miami, Miller School of Medicine, Miami, FL. Laboratory of Functional Molecular Solids, Ministry of Education; School of Chemistry and Materials Science, Anhui Normal University, Wuhu 241000, China Laboratory of Medical Biology, Medical Research Center The Affiliated Hospital of Qingdao University & The Biomedical Sciences Institute of Qingdao University (Qingdao Branch of SJTU Bio‐X Institutes), Qingdao University Qingdao 266000 Shangdong China From the Vascular Biology Center and Departments of Pediatrics and Pharmacology, Medical College of Georgia, Augusta, Ga. Division of Advanced Manufacturing, Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, China Department of Gynaecology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China Department of Epidemiology and Biostatistics School of Public Health, Anhui Medical University Hefei China Department of Biochemistry and Molecular Biology and Tulane Aging Center, Tulane University Health Science Center, New Orleans, LA 1 Integrated Chinese and Western Medicine, School of Preclinical Medicine, Beijing University of Chinese Medicine Department of Neonatology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China Department of Laboratory Medicine , Zhongnan Hospital of Wuhan University , Wuhan , P.R. China College of Mechanical and Electronical Engineering, Gansu Agricultural University, Lanzhou 730070, China Department of Chinese Materia Medica and Natural Medicines, School of Pharmacy, Air Force Medical University, Xi′an, China Clinical Epidemiology and EBM Unit, National Clinical Research Center for Digestive Disease, Beijing Friendship Hospital, Capital Medical University, Beijing, China Department of Radiotherapy, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, The Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, Jiangsu 210000, P.R. China School of Tourism, Hubei University, Wuhan 430062, China Research Center of Basic Medicine, Jinan Central Hospital, Cheeloo College of Medicine, Shandong University Jinan China KBP Biosciences, 401, Building 2, Jinan Pharm Valley, North Section of Gangxing Three Road, Jinan, Shandong, 250101, P. R. China State Key Laboratory of Explosion Science and Technology, Beijing Institute of Technology, No.5, Zhongguancun South Street, Haidian District, Beijing 100081, China Life Sciences Institute and Innovation Center for Cell Signaling Network, Zhejiang University, Hangzhou 310058, China. Stomatological Healthcare Center, Shenzhen Maternity and Child Healthcare Hospital Affiliated to Southern Medical University, Shenzhen 518048, China College of Chemistry Chemical Engineering and Materials Science Shandong Normal University Jinan 250014 P.R. China Department of Gynaecology and Obstetrics, Rizhao Maternal and Child Health Care Hospital CAS Key Laboratory of Behavioral Science Institute of Psychology Beijing China; Department of Psychology University of Chinese Academy of Sciences Beijing China Center for Reproductive Medicine Shandong Provincial Hospital Affiliated to Shandong University 250021 Jinan China; National Research Center for Assisted Reproductive Technology and Reproductive Genetics Jinan China; The Key Laboratory for Reproductive Endocrinology of Ministry of Education Jinan China; Shandong Provincial Key Laboratory of Reproductive Medicine Jinan China College of Mechanical and Electrical Engineering, Shihezi University, Shihezi 832003, China; Xinjiang Production and Construction Corps Key Laboratory of Modern Agricultural Machinery, Shihezi 832003, China; Engineering Research Center for Production Mechanization of Oasis Special Economic Crop, Ministry of Education, Shihezi 832003, China Department of Chemistry Northeast Normal University Changchun 130024 China; State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic Chemistry 345 Lingling Lu Shanghai 200032 China Department of Cardiology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China (mainland) Department of Respiratory and Critical Care Medicine Tianjin Medical University General Hospital Tianjin China Department of Emergency, Beijing Anzhen Hospital Capital Medical University Beijing China Central Laboratory, Peking University School and Hospital of Stomatology , 100081, Beijing, China 2Department of Pathology, School of Basic Medicine, Tongji Medical College, HUST, Wuhan, China.; 3Institute of Pathology, Tongji Hospital, Tongji Medical College, HUST, Wuhan, China. Guizhou University School of Medicine, Guiyang, Guizhou550025, China; Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Key Laboratory for Research and Evaluation of Radiopharmaceuticals (National Medical Products Administration), Department of Nuclear Medicine, Peking University Cancer Hospital & Institute, Beijing100142, China School of Traditional Chinese Medicine and School of Pharmaceutical Sciences Southern Medical University Guangzhou Guangdong 510515 China Biotechnology Research Institute, Chinese Academy of Agricultural Sciences, Beijing 100081, China Department of Occupational and Environmental Health, the Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment, School of Public Health, Air Force Medical University Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. Department of Allergy, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences Peking Union Medical College Beijing China; Beijing Key Laboratory of Precision Medicine for Diagnosis and Treatment on Allergic Diseases Beijing China; National Clinical Research Center for Dermatologic and immunologic Diseases Beijing China Department of Anesthesia, Tianjin Central Hospital of Gynecology & Obstetrics Jiangxi Key Laboratory of Power Batteries and Materials, Faculty of Materials Metallurgy and Chemistry, Jiangxi University of Sciences and Technology, Ganzhou 341000, China; Yichun Lithium New Energy Industry Research Institute, Jiangxi University of Science and Technology, Yichuan 336023, China Nephrology, Huashan Hospital, Fudan University, Shanghai, China College of Plant Protection/Key Laboratory of Integrated Management of Crop Diseases and Pests, Ministry of Education Nanjing Agricultural University Nanjing 210095 People's Republic of China Department of Hematology Peking University Shenzhen Hospital Shenzhen China Department of Nephrology, The First Affiliated Hospital of Zhengzhou University Zhengzhou 450052, Henan, P. R. China. Key Laboratory of Nonferrous Metals Chemistry and Resources Utilization of Gansu Province, State Key Laboratory of Applied Organic Chemistry, and College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, Gansu, 730000 PR China Institute of Biological and Medical Engineering State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing 210009, China; Department of Pharmacology, School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China; Chongqing Innovation Institute of China Pharmaceutical University, Chongqing 4015, China Department of Physics and Texas Center for Superconductivity, University of Houston, Houston, TX 77204; Department of Grassland Science, College of Animal Science and Technology China Agricultural University Beijing China Shenzhen Institute of Technology, Guangdong, Shenzhen 518116, China College of Chemistry; Liaoning University; Shenyang 110036; P. R. China Department of Pharmacy, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, Jiangsu 215000, P.R. China Southwest oil & Gas field Company, Petro China, Chengdu, Sichuan 610017, P. R. China Department of General Surgery, The Affiliated Cancer Hospital of Nanjing Medical University and Jiangsu Cancer Hospital and Jiangsu Institute of Cancer Research, Nanjing 210029, P.R. China Shandong Runde Biotechnology Co.,Ltd., Taian 271000, P.R. China Department of Pathology, Shanghai Tenth People's Hospital, Tongji University, Shanghai 200072, P.R. China Florida State University Department of Pediatric Surgery, First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan 450052, China. Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, National Clinical Research Center for Digestive Disease, Beijing Digestive Disease Center, Beijing Key Laboratory for Precancerous Lesion of Digestive Disease , Beijing, 100050 , China College of Computer Science and Technology, China University of Petroleum (East China), Qingdao 266580, China Shanghai East Clinical Medical College, Nanjing Medical University, Nanjing, Jiangsu 211166, P.R. China State Key Laboratory of Physical Chemistry of Solid Surfaces; College of Chemistry and Chemical Engineering; Xiamen University; Xiamen; China Public Health School of Peking Union Medical College, Beijing 102200, China. Department of Anesthesiology, Shenzhen University General Hospital, Shenzhen University Clinical Medical Academy, Shenzhen University, Shenzhen 518055, China Department of Thyroid Surgery, Weihai Traditional Chinese Medicine Hospital, Weihai, Shandong, China Suzhou municipal hospital Suzhou Jiangsu China Laboratoire Ecologie Systématique Evolution, Univ. Paris-Sud, CNRS, AgroParisTech, Université Paris-Saclay, Orsay, France State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China 2 Department of Nutrition and Food Hygiene School of Public Health China Medical University Shenyang China Department of Dermatology, The First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, Xinjiang Uyghur Autonomous Region, China Clinical Epidemiology and EBM Unit, Beijing Friendship Hospital, Capital Medical University, National Clinical Research Center for Digestive Disease, Beijing, PR China Jiangsu Key Laboratory of Advanced Lasser Materials and Devices, School of Physics and Electronic Engineering, Jiangsu Normal University, Xuzhou 221116, China Tianjin Children's Hospital, Tianjin, People's Republic of China College of Veterinary Medicine, Gansu Agricultural University, Lanzhou 730070, China; Gansu Province Livestock Embryo Engineering Research Center, Lanzhou 730070, China Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China; China National Clinical Research Center for Neurological Diseases, Beijing, China; Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China; Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China; Beijing Translational Engineering Center for 3D Printer in Clinical Neuroscience, Beijing, China Department of Plastic Surgery, Tongren Hospital of Wuhan University (Wuhan Third Hospital) , Wuhan 430060 , China College of Medicine and Forensics, Xi’an Jiaotong University, Xi’an, China and Department of Respiratory and Critical Care Medicine, The Affiliated Changzhou No.2 People’s Hospital of Nanjing Medical University, Changzhou 213003, China Department of Urology, the First Hospital of Peking University, Beijing 100034, China. Email: zhangqiangbmu@vip.sina.com. Key Laboratory of Northwest Resource, Environment and Ecology, MOE, Xi’an University of Architecture and Technology, Xi’an 710055, China; Key Lab of Aerosol Chemistry & Physics, SKLLQG, Institute of Earth Environment, Chinese Academy of Sciences, Xi’an 710061, China Department of Endocrinology Qilu Hospital, Shandong University Jinan China The Macromolecules and Interfaces Institute, Virginia Tech, Blacksburg, Virginia 24061 Teaching and Research Section of Surgery, Xiangnan University Affiliated Hospital, Chenzhou, Hunan 423000, China Laboratory of Animal Cell Biology and Embryology College of Veterinary Medicine Nanjing Agricultural University Nanjing China Genelux, San Diego, CA 92109; Key Laboratory of Pest Monitoring and Green Management MOA and College of Plant Protection China Agricultural University Beijing China Department of General Surgery, The Affiliated Cancer Hospital of Nanjing Medical University, Nanjing 210009, PR China Department of Oral and Maxillofacial Surgery; Nanjing Stomatological Hospital; Medical School of Nanjing University; Nanjing; China Medical School, Tongji University, Shanghai, China Jilin Province Key Laboratory of Organic Functional Molecular Design & Synthesis Department of Chemistry Northeast Normal University 130024 Changchun China; State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic Chemistry Chinese Academy of Sciences 345 Lingling Lu 200032 Shanghai China Institute of Quality and Standard of Agro‐products Zhejiang Academy of Agricultural Sciences Hangzhou P. R. China; Agricultural Ministry Key Laboratory for Pesticide Residue Detection Hangzhou P. R. China; Key Laboratory of Detection for Pesticide Residues and Control of Zhejiang Hangzhou P. R. China Faculty of Materials Metallurgy and Chemistry, Key Laboratory of Power Batteries and Relative Materials, Jiangxi University of Science and Technology, Ganzhou 341000, China Departments of Blood Transfusion, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China; JiangXi Key Laboratory of Transfusion Medicine, Nanchang, Jiangxi, China Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Shaanxi University of Chinese Medicine , Xianyang, China Department of Human Anatomy, Zunyi Medical College, Zunyi, Guizhou, China. Medical College of Guizhou University Guiyang Guizhou 550002 China School of Chinese Pharmacy and §Center of Scientific Experiment, Beijing University of Chinese Medicine, Beijing 100029, China Department of Clinical Pharmacology, The Second Affiliated Hospital of Anhui Medical University, Hefei 230601, China Department of Radiology Shandong Provincial Third Hospital Jinan Shandong China School of Mechanical, Medical and Process Engineering, Queensland University of Technology, 2 George Street, Brisbane, Queensland 4000, Australia; College of Materials Science and Engineering, Taiyuan University of Technology, Taiyuan, Shanxi 030024, China Agro‐Environmental Pollution Remediation Research Center Agro‐Environmental Protection Institute, Ministry of Agriculture and Rural Affairs Tianjin 300191 China The University of Nottingham; c/o Cochrane Skin Group; A103, King's Meadow Campus Lenton Lane Nottingham UK NG7 2NR College of Chemistry, Liaoning University, Shenyang, Liaoning, 110036, P. R. China Institute of Forest Tree Genetics and Breeding, Taishan Academy of Forestry Sciences, Tai’an, China Department of Pathology and Laboratory Medicine and Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University; China National Clinical Research Center for Neurological Diseases; Center of Stroke, Beijing Institute for Brain Disorders; Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease; and Key Laboratory of Green Chemical Media and Reactions (Ministry of Education), Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals, School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, Henan 453007, P.R. China Central University of Finance and Economics, Beijing, China Economic and Management School, Chengdu, Agricultural College 5 , Chengdu, China Department of Digestive China‐Japan Union Hospital of Jilin University Changchun China Jiangxi Key laboratory of Power Battery and Material, Faculty of Materials Metallurgy and Chemistry, Jiangxi University of Science and Technology, Ganzhou 341000, China; Yichun Lithium New Energy Industry Research Institute, Jiangxi University of Science and Technology, Ganzhou 341000, China Department of Analytical Chemistry, College of Chemistry, Jilin University, Changchun 130012, China State Key Laboratory for Advanced Metals and Materials, School of Materials Science and Engineering, University of Science and Technology Beijing, Beijing 100083, P. R. China Qingshan District Center for Disease Control and Prevention Wuhan China Department of Materials Science and Engineering National University of Singapore Singapore 117574 Singapore Department of Oncology Affiliated Hospital of Medical College Qingdao University Qingdao China College of Food and Biological Engineering, Jimei University, Xiamen, China 361021; Fujian Collaborative Innovation Center for Exploitation and Utilization of Marine Biological Resources, Xiamen, Fujian, China 361102 Key Laboratory of Optic-electric Sensing and Analytical Chemistry for Life Science, MOE; Shandong Key Laboratory of Biochemical Analysis; Key Laboratory of Analytical Chemistry for Life Science in Universities of Shandong; College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, People’s Republic of China Department of Analytical Chemistry, College of Chemistry, Jilin University, Changchun, 130012, China Department of Endocrinology Nanfang Hospital Southern Medical University Guangzhou China Department of Pharmacy Guilin Medical University No. 109 Huancheng Road Guilin 541004 P.R. China Department of Pharmacy The Second Affiliated Hospital of Army Medical University Chongqing China Department of Materials Science and Engineering, Harbin Institute of Technology, Shenzhen 518055, China College of Medicine & Forensic, Health Science Center, Xi’an Jiao Tong University, Xi’an, Shaanxi, China State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Disease The First Affiliated Hospital of Guangzhou Medical University Guangzhou China; Division of Translational and Regenerative Medicine The University of Arizona College of Medicine Tucson AZ USA; Department of Medicine The University of Arizona College of Medicine Tucson AZ USA; Department of Physiology The University of Arizona College of Medicine Tucson AZ USA University of Paris, Imagine Institute, Paris, France. College of Mechanical and Electrical Engineering, Shihezi University, Shihezi, China Department of Respiratory, Tianjin Medical University General Hospital, Tianjin, China Translational Medicine Center, Honghui Hospital, Xi’an Jiaotong University, Xi’an, Shaanxi, China MOE Key Laboratory of Bioorganic Phosphorous Chemistry and Chemical Biology, Department of Chemistry, Tsinghua University, Beijing 100084, China Key Laboratory of Endocrinology, Translational Medicine Centre, Ministry of Health, Department of Endocrinology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China Department of Infectious Diseases, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China Department of Medical Oncology, Affiliated Hospital of Hebei University, Hebei Key Laboratory of Cancer Radiotherapy and Chemotherapy, Baoding, Hebei 071000, P.R. China National Institute for Communicable Disease Control and Prevention and State Key Laboratory for Infectious Disease Prevention and Control, Chinese Center for Disease Control and Prevention, P.O. Box 5, Changping, Beijing 102206, Peoples Republic of China Department of Forest Resources and Environmental Conservation, Virginia Tech, Blacksburg, VA China Academy of Information and Communications Technology, Beijing 100161, China Department of Respiratory Medicine, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China. Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, the Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China School of Life Science and Technology, Xidian University, Xi’an 710071, China, and Engineering Research Center of Molecular and Neuro Imaging, Ministry of Education, China; Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Sciences, 95 ZhongGuanCun East Road, 100190 Beijing, China Institute of Chemical Materials China Academy of Engineering Physics Mianyang Sichuan 621900 P. R. China Beijing Key Laboratory of Traditional Chinese Veterinary Medicine, Beijing University of Agriculture, Beijing, P.R. China; and; Department of Pathophysiology, College of Veterinary Medicine, China Agricultural University, Beijing, P.R. China. Key Laboratory of Synthetic Rubber, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, P. R. China Henan Provincial Key Laboratory of Medical Genetics, Institute of Medical Genetics, Henan Provincial People's Hospital, Zhengzhou, Henan 450003, China. yichuansuolsx@126.com. Jiangsu Province Key Laboratory of Anesthesiology Xuzhou Medical University Xuzhou Jiangsu China; Department of Anesthesiology The Affiliated Hospital of Xuzhou Medical University Xuzhou Jiangsu China Departmert of Pharmaceutics, School of Phammacy, Ningxia Medical University, No. 1160 Shengli South Street, Yinchuan 750004, PR China National Engineering Research Center for Biomaterials, Sichuan University, 29 Wangjiang Road, Chengdu 610064, China Pneumology Department, The Traditional Chinese Medicine Hospital Affiliated to Xinjiang Medical University, Urumqi City, China Department of Applied Chemistry, College of Science, China Agricultural University, Beijing 100193, People's Republic of China College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, PR China Engineering Research Center for Waste Oil Recovery Technology and Equipment, Chongqing Key Laboratory of Catalysis and New Environmental Materials, College of Environment and Resources, Chongqing Technology and Business University, Chongqing 400067, People's Republic of China Department of Biochemistry and Molecular Biology, Tulane University School of Medicine, New Orleans, LA 1 Department of Urology, Peking University First Hospital and Institute of Urology, Peking University, China; National Research Center for Genitourinary Oncology, China; Joint Center for Cancer Epigenetics, China School of Chemistry and Chemical Engineering Jiangsu University Zhenjiang 212013 P. R. China Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, 1219 Zhongguan West Road, Zhenhai District, Ningbo, Zhejiang Province 315201, P. R. China School of Materials Science and Engineering, Tianjin University, Tianjin 300072, P. R. China; Tianjin Key Laboratory of Composite and Functional Materials, Tianjin University, Tianjin 300072, P. R. China School of Pharmaceutical Sciences, Health Science Center Shenzhen University Shenzhen China 1Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas. Department of Respirology, Qingdao Women and Children’s Hospital, Qingdao 266034, People’s Republic of China Institute of Pathology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China;; Department of Pathology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China Innovation Center of Pesticide Research, Department of Applied Chemistry, College of Science, China Agricultural University, Beijing 100193, China Key Laboratory of Synthetic Rubber, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China; University of Chinese Academy of Sciences, Beijing 100039, China Vascular Biology Center and; Pharmacology of the Medical College of Georgia, Augusta, Georgia Institute of Liver Diseases, Shuguang Hospital Afﬁliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China Department of Biochemistry and Molecular Biology, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030; and Laboratory of Molecular Cardiology, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1Department of Colorectal Cancer Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, China. State Key Laboratory of Estuarine and Coastal Research, School of Life Sciences, East China Normal University, Shanghai, China Departments of Dermatologic Surgery, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, Jiangsu Province, China Department of Endocrinology Key Laboratory of Endocrinology Ministry of Health Peking Union Medical College Hospital Diabetes Research Center of Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100730 China School of Food Science and Bioengineering, Xihua University, Chengdu 610039, China Fuzhou University, China Department of Traditional Chinese Medicine,PUMC Hospital,CAMS and PUMC,Beijing 100730,China. School of Computer Science and Engineering, University of Electronic Science and Technology of China, Chengdu, China Unit of Cell Biology and Imaging Study of Pathogen Host Interaction, The Center for Microbes, Development and Health, Key Laboratory of Molecular Virology and Immunology, Shanghai Institute of Immunity and Infection, Chinese Academy of Sciences , Shanghai 200031 , China State Key Laboratory of Natural Medicines Department of Natural Medicinal Chemistry China Pharmaceutical University Nanjing China Jiangsu Key Laboratory of Environmentally Friendly Polymeric Materials, School of Materials Science and Engineering, Jiangsu Collaborative Innovation Centre of Photovoltaic Science and Engineering, Changzhou University, Changzhou, Jiangsu 213164, P. R. China College of Sciences Xi'an University of Technology Xi'an China Department of Occupational and Environmental Health, The Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment, School of Public Health Air Force Medical University Xi'an China School of Chemistry and Chemical Engineering, Liaocheng University, Liaocheng 252059, China Department of Urology, Peking University First Hospital and Institute of Urology, Peking University, Beijing 100034, China Department of Mechanical Engineering and §Department of Civil and Environmental Engineering, University of Hawaii at Manoa, Honolulu, Hawaii 96822 United States; School of Materials Science and Engineering and ∥School of Mechanical Engineering, University of Science and Technology Beijing, Beijing 100083, China Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, Jiangsu Key Laboratory of Bio-Functional Materials, School of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, P. R. China State Key Laboratory of Organic‐Inorganic Composites & Beijing Laboratory of Biomedical Materials & Beijing Advanced Innovation Center for Soft Matter Science and Engineering Beijing University of Chemical Technology Beijing 100029 China State Key Laboratory and Institute of Elemento‐Organic Chemistry Collaborative Innovation Center of Chemical Science and Engineering School of Materials Science and Engineering Nankai University Tianjin 300071 China Fujian Institute of Hematology, Fujian Provincial Key Laboratory on Hematology, Fujian Medical University Union Hospital, Fuzhou, China. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA Center for Bioelectronics & Biosensors, The Biodesign Institute, Department of Electrical Engineering, Arizona State University, Tempe, Arizona 85287, and Department of Chemistry, Tsinghua University, Beijing 100084, China Gastroenterology Department, Beijing Friendship Hospital, Capital Medical University, Beijing, China Department of General Surgery, Aerospace Central Hospital, Beijing 100049, China. College of Food and Biological Engineering Chengdu University Chengdu PR China College of Pharmacy Ningxia Medical University Yinchuan P. R. China Key Laboratory of Sensor Analysis of Tumor Marker; Ministry of Education; Shandong Key Laboratory of Biochemical Analysis; Key Laboratory of Analytical Chemistry for Life Science in Universities of Shandong; College of Chemistry and Molecular Engineering. Qingdao University of Science and Technology Jilin Province Key Laboratory of Organic Functional Molecular Design & Synthesis, Department of Chemistry Northeast Normal University Changchun 130024 P. R. China; State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic Chemistry Chinese Academy of Sciences 345 Lingling Road Shanghai 200032 P. R. China Cancer Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Department R47A, 100 Abbott Park Road, Abbott Park, Illinois 60064 Translational Medicine Center, Hong Hui Hospital, Xi’an Jiaotong University College of Medicine, Xi’an 710054, China Center for Plant Water-use and Nutrition Regulation and School of Life Sciences, Joint International Research Laboratory of Water and Nutrient in Crop, Fujian Agriculture and Forestry University, Jinshan Fuzhou, China College of Chemistry; Chemical Engineering and Materials Science; Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong; Key Laboratory of Molecular and Nano Probes; Ministry of Education Department of Botany University of British Columbia Vancouver BC Canada V6T 1Z4 School of Materials Science and Engineering; Henan University of Science and Technology; Luoyang; China Department of Chemistry and Biochemistry; Florida State University; 95 Chieftain Way Tallahassee FL 32303 USA Department of Cardiology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China Department of Medical Psychology; Shandong University School of Medicine; Jinan Shandong China Genelux Corporation San Diego Science Center San Diego CA; Department of Radiation Medicine and Applied Sciences and Center for Advanced Radiotherapy Technologies University of California San Diego La Jolla CA Key Laboratory of Bio‐resource and Eco‐environment of Ministry of Education, College of Life Sciences, State Key Laboratory of Hydraulics and Mountain River Engineering Sichuan University Chengdu China Department of Materials Science and Engineering, National University of Singapore, 9 Engineering Drive 1, Singapore 117575, Singapore Department of Dermatology, Peking University Third Hospital, Beijing, China Department of Gastroenterology China, Japan Union Hospital, Jilin University Changchun, Jilin Province 130033, China Department of Thoracic Surgery Beijing Children’s Hospital Capital Medical University National Center for Children’s Health Beijing China Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia; and Jilin Province Key Laboratory of Organic Functional Molecular Design & Synthesis Department of Chemistry Northeast Normal University Changchun 130024 China; State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic Chemistry Chinese Academy of Sciences 345 Lingling Lu Shanghai 200032 China Guangdong Academy of Forestry, Guangzhou 510520, China; Guangdong Provincial Key Laboratory of Silviculture, Protection and Utilization, Guangzhou 510520, China Department of Pediatric Dentistry Nanjing Stomatological Hospital Medical School of Nanjing University Nanjing China Department of Neurosurgery, Chinese PLA General Hospital (former Department of Neurosurgery, the Fifth Medical Center of Chinese PLA General Hospital), Beijing, China Department of Biochemistry and Molecular Biology, School of Basic Medicine, Ningxia Medical University, Yinchuan 750004, China. College of Life Science, Northwest University, Xi'an 710069, China. Department of Periodontology, Hospital of Stomatology, Jilin University, 1500 Tsinghua Road, Chaoyang District, Changchun 130021, China Public Technology Service Center, Institute of Oceanology Chinese Academy of Sciences Qingdao China Department of Pediatrics Heze Municiple Hosptial Heze Shandong China Key Laboratory of Photovoltaic and Energy Conservation Materials, Institute of Solid State Physics, HFIPS, Chinese Academy of Sciences, Hefei 230031, China; University of Science and Technology of China, Hefei 230026, China Division of Advanced Manufacturing; Tsinghua Shenzhen International Graduate School; Shenzhen; China; State Key Laboratory of Precision Measurement Technology and Instruments Department of Cardiology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing 100730, China 1Department of Nephrology, Huashan Hospital, Fudan University, Shanghai, China; 2National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, China Institute of Geographic Sciences and Natural Resources Research, Chinese Academy of Sciences, Beijing 100101, China. School of Life Sciences, The Chinese University of Hong Kong, Shatin, Hong Kong, SAR, China Genelux Corporation, San Diego Science Center, San Diego, California, USA; Department of Radiation Oncology, Moores Cancer Center, University of California, San Diego, La Jolla, California, USA School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China Medical Research Center, Southwest Hospital, Third Military Medical University (Army Medical University), 400038 Chongqing, China. School of Chemistry and Chemical Engineering, Chongqing University, Chongqing 400030, China School of Basic Medicine, Beijing University of Chinese Medicine, Beijing, China; Department of Oncology, Tenth People’s Hospital, Tongji University, Shanghai 200072, P. R. China Department of Urology, Peking University First Hospital, Beijing, China.; Institute of Urology, Peking University, Beijing, China.; National Urological Cancer Center, Beijing, China. 1Department of Endocrinology,Chinese PLA General Hospital,Beijing 100853,China; 3Department of Endocrinology,PLA Army General Hospital,Beijing 100700,China. State Key Laboratory of Medicinal Chemical Biology, Collaborative Innovation Center for Biotherapy, 2011 Collaborative Innovation Center of Tianjin for Medical Epigenetics, Tianjin Key Laboratory of Protein Sciences and College of Life Sciences, Nankai University, Tianjin 300071, China; Department of Gastroenterology and Hepatology The Second Affiliated Hospital of Chongqing Medical University Chongqing China St. Giles Laboratory of Human Genetics of Infectious Diseases, The Rockefeller University, New York, NY 10065; Department of Medicinal Chemistry, School of Pharmacy, Fudan University, Shanghai, China Faculty of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang 110016, China St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Department of Physics, Philipps University Marburg, Marburg, Germany Team Physiopathology and Treatment of Viral Hepatitis Centre de Recherche sur l'Inflammation Laboratory of Excellence Labex INFLAMEX INSERM UMR‐1149 University Denis Diderot Paris 7 PRES Sorbonne Paris Cité Paris France Key Laboratory of Synthetic Rubber, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China Department of Computer Science and Technology, East China Normal University, Shanghai 200241, China Key Laboratory of Bio‐Inspired Smart Interfacial Science and Technology of Ministry of Education Beijing Key Laboratory of Bio‐Inspired Energy Materials and Devices School of Chemistry Beihang University Beijing 100191 P. R. China Central Laboratory, School of Stomatology, Peking University, Beijing, China Key Laboratory of Textile Science and Technology, Ministry of Education, College of Textiles, Donghua University, Songjiang District, Shanghai 201620, China College of Bioscience and Biotechnology, Shenyang Agricultural University, Shenyang, Liaoning, China Department of Mechanical Engineering; Vanderbilt University; Nashville, USA School of Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China Department of Pharmacology; The Second Affiliated Hospital of Army Medical University; Chongqing; China Hubei International Scientific and Technological Cooperation Base of Animal Nutrition and Gut Health, Wuhan Polytechnic University, Wuhan, China. Institute of Cancer Stem Cell, Cancer Center, Dalian Medical University, Dalian, China Department of Epidemiology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union of Medical College, Beijing, People's Republic of China; School of Art and Design, Wuhan University of Technology, Wuhan 430070, China State Key Laboratory of Biotherapy/Collaborative Innovation Center of Biotherapy, West China Hospital, Sichuan University, Chengdu, China Translational Research Institute of Brain and Brain-Like Intelligence, Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation, Department of Anesthesiology and Perioperative Medicine, Shanghai Fourth People’s Hospital Affiliated to Tongji University School of Medicine, 1279 Sanmen Road, Hongkou District, Shanghai 200434, P.R. China Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering Feringa Nobel Prize Scientist Joint Research Center Frontiers Science Center for Materiobiology and Dynamic Chemistry School of Chemistry and Molecular Engineering East China University of Science & Technology 130 Meilong Road Shanghai 200237 China Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals, Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, Henan 453007, P. R. China Institute of Cancer Stem Cell, Cancer Center, Dalian Medical University, Dalian, 116044, Liaoning, P.R.China Department of Respiratory Medicine, Affiliated Nanjing Brain Hospital Nanjing Medical University Nanjing Jiangsu 210029 China; Clinical Center of Nanjing Respiratory Diseases and Imaging Nanjing Jiangsu 210029 China Key Lab of Ecological Environment Science and Technology, First Institute of Oceanography, Ministry of Natural Resources, Qingdao 266061, China Department of Neurology, Inst Translat Med, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People’s Hospital, Shenzhen 518035, P. R. China Department of Nutrition, Beijing Tongren Hospital, Beijing 100005, China. Department of Chemistry, Xi’an-Jiaotong Liverpool University, Suzhou, 215123, China; Department of Chemistry, University of Liverpool, Liverpool, L69 7ZD, UK College of Pharmacy and Biological Engineering Chengdu University Chengdu China Center of Clinical Aerospace Medicine, School of Aerospace Medicine, Key Laboratory of Aerospace Medicine of Ministry of Education Air Force Medical University Xi'an China Division of Nephrology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China; Department of Endocrinology, Qilu Hospital, Shandong University, Jinan, Shandong, China Key Laboratory of Fluid and Power Machinery, Ministry of Education, School of Energy and Power Engineering, Xihua University, Chengdu 610039, P.R.China; Vehicle Measurement, Control and Safety Key Laboratory of Sichuan Province, School of Automobile and Transportation, Xihua University, Chengdu 610039, P.R.China BioTechnology Institute Univ. of Minnesota 140 Gortner Lab. of BioChemistry St. Paul MN 55108 USA Department of Clinical Laboratory, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China Department of Chemistry, Northeast Normal University, Changchun, 130024, People's Republic of China Department of Chemistry; Northeast Normal University; Changchun; China College of Science, Nanjing Forestry University, Nanjing 210037, China MOE Key Laboratory of Bioorganic Phosphorous Chemistry and Chemical Biology, Department of Chemistry, Tsinghua University, Beijing, 100084, China The Affiliated Hospital of Qingdao University, Qingdao 266003, China; School of Stomatology of Qingdao University, Qingdao 266003, China Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, National Clinical Research Center for Digestive Disease, Beijing Digestive Disease Center, Beijing Key Laboratory for Precancerous Lesion of Digestive Disease, Beijing, China; Department of Neurosurgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China Department of Biomedical Engineering, The Hong Kong Polytechnic University, Hong Kong, China Department of Hematology, Peking University Shenzhen Hospital, Shenzhen 518036, Guangdong Province, China. From the School of Automation and Nanomedicine and Biosensor Laboratory, Harbin University of Science and Technology, Haerbin, China; Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Sciences, Beijing, China; and Department of Biomedical Engineering, College of Engineering, Peking University, Beijing, China Department of Biotherapy Shenzhen Luohu People's Hospital Shenzhen China Department of Radiology Baoding No. 1 Central Hospital Baoding China Centre for Pharmaceutical Innovation and Development School of Pharmacy and Medical Science University of South Australia City East Campus Playford building Frome Rd Adelaide South Australia 5000 Australia Department of Toxicology, Tianjin Centers for Disease Control and Prevention, No. 6, Huayue Road, Hedong District, Tianjin, 300011, PR China. Department of Pediatric; The First Affiliated Hospital of Zhengzhou University; Zhengzhou City China Department of Oncology, The Central Hospital of Enshi Tujia and Miao Autonomous Prefecture, Hubei, China Xuzhou Medical University, Xuzhou, China Division of Nephrology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou 350002, China; Ganjiang Innovation Academy, Chinese Academy of Sciences, Ganzhou, 341000, China Key Laboratory of Endocrinology, Ministry of Health, Department of Endocrinology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China Department of Cardiovascular Surgery Shandong Provincial Hospital affiliated to Shandong University Shandong China School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang 110016, China Department of Respiratory Medicine, Affiliated Changzhou No.2 People's Hospital, Nanjing Medical University, Changzhou, China AND Department of Respiratory Medicine, Nanjing General Hospital of Nanjing Military Command, Nanjing, China. Department of Endocrinology, NHC Key Laboratory of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China Key Laboratory of Bio‐Resources and Eco‐Environment of Ministry of Education College of Life Sciences State Key Laboratory of Hydraulics and Mountain River Engineering Sichuan University Chengdu 610065 China State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, PR China Department of Neonatology The First Affiliated Hospital of Zhengzhou University Zhengzhou China Department of Biomedical Sciences Colorado State University Fort Collins CO 80523 United States College of Chemistry, Chemical Engineering and Materials Science, Shandong Normal University, Jinan250014, China The MOE Key Laboratory of Standardization of Chinese Medicines, The SATCM Key Laboratory of New Resources and Quality Evaluation of Chinese Medicines, The Shanghai Key Laboratory for Compound Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai201203, China Nephrology, Huashan Hospital, Fudan University, Shanghai, China; National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, China School of Materials Science and Engineering Key Laboratory of Advanced Ceramics and Machining Technology Ministry of Education Tianjin University Tianjin 300350 P. R. China Department of Otorhinolaryngology, the Drum Tower Hospital Affiliated of the Medical School in Nanjing University, Nanjing, 210008, China. lsqsissy@jlonline.com Hubei Collaborative Innovation Center for High-Efficiency Utilization of Solar Energy, Hubei University of Technology; School of Materials and Chemical Engineering, Hubei University of Technology Key Laboratory for Thin Film and Microfabrication Technology of the Ministry of Education, Department of Instrument Science and Engineering, School of Electronic Information and Electrical Engineering, Institute of Nano Biomedicine and Engineering, Shanghai Jiao Tong University, Shanghai, China; Department of Spinal Surgery Affiliated Liaocheng Second People Hospital, Taishan Medical College Liaocheng China State Key Program of Microbiology and Department of Microbiology College of Life Sciences Nankai University Tianjin P. R. China Suzhou Key Laboratory of Nanotechnology and Biomedicine, Institute of Functional Nano and Soft Materials (FUNSOM) and Collaborative Innovation Center of Suzhou Nano Science and Technology (NANO−CIC), Soochow University, Suzhou 215123, China Intelligent Medical Research Center, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China 1Department of Gynecologic Oncology, and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas. Institute of Nano Biomedicine and Engineering, Key Laboratory for Thin Film and Microfabrication Technology of the Ministry of Education, Department of Instrument Science and Engineering, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China Department of Physics, School of Science, South China University of Technology, Guangzhou 510640, China. z.qian06@mail.scut.edu.cn College of Chemistry and Chemical Engineering, Qingdao University, Qingdao, Shandong 266071, China Unilever R&D Shanghai Shanghai China Department of Chemistry; University of Science and Technology of China; Hefei; China State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei‐MOST) and Key Laboratory for Oral Biomedicine of Ministry of Education (KLOBM), School and Hospital of Stomatology Wuhan University Wuhan China Department of Infectious Diseases, The Affiliated Hospital of Southwest Medical University, Lu Zhou, Si Chuan, China. Department of Hepatobiliary Surgery, The Affiliated Hospital of Inner Mongolia Medical University, Huhhot, P.R. China School of Pharmaceutical Sciences, Chongqing University, Chongqing, China National Immunization Program, Chinese Center for Disease Control and Prevention , Beijing Xiamen Products Quality Supervision & Inspection Institute, Xiamen, Fujian 361005, China Foshan Hospital of Traditional Chinese Medicine Foshan Guangdong China National Clinical Research Center of Digestive Diseases Beijing China; Clinical Epidemiology and EBM Center, Beijing Friendship Hospital Capital Medical University Beijing China Center for Plant Water‐use and Nutrition Regulation and College of Resources and Environment, Joint International Research Laboratory of Water and Nutrient in Crop Fujian Agriculture and Forestry University Fuzhou China Affiliated Tumor Hospital of Xinjiang Medical University, Xinjiang Medical University, State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Urumqi, Xinjiang 830011, China Key Laboratory of Animal Physiology and Biochemistry; Ministry of Agriculture; College of Veterinary Medicine; Nanjing Agricultural University; Nanjing PR China School of Materials Science and Technology, China University of Geosciences, Beijing, 100083, China College of Mechanical and Electrical Engineering, Shihezi University, Shihezi 832003, China; Engineering Research Center for Production Mechanization of Oasis Special Economic Crop, Ministry of Education, Shihezi 832003, China; Xinjiang Production and Construction Corps Key Laboratory of Modern Agricultural Machinery, Shihezi 832003, China St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY, USA. Department of Gynecology and Obstetrics The First Affiliated Hospital of Xi'an Jiaotong University Xi'an Shaanxi China Department of Chemistry, Northeast Normal University, Changchun 130024, China zhangq651@nenu.edu.cn; liuqun@nenu.edu.cn Chinese Herb Medicine Division, Zhejiang Agriculture and Forestry University, 666 Wusu Street, Hangzhou 311300, China; The State Key Laboratory of Subtropical Silviculture, Zhejiang Agriculture and Forestry University, 666 Wusu St, Hangzhou 311300, China Hubei Key Laboratory of Animal Nutrition and Feed Science, Wuhan Polytechnic University, Wuhan 430023, China Departments of Neurosurgery and; Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China College of Veterinary Medicine Nanjing Agricultural University Nanjing P. R. China State Key Laboratory Base of Eco-chemical Engineering, Taishan Scholar Advantage and Characteristic Discipline Team of Eco-chemical Process and Technology, Qingdao University of Science and Technology, Qingdao 266042, China; College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, China College of Chemistry; Liaoning University; Shenyang 110036; China Department of Chemistry and Biochemistry, Utah State University, 0300 Old Main Hill, Logan, Utah 84322-0300, United States College of Life Sciences, Hebei Normal University, Shijiazhuang 050016, China. Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing 210009, China Department of Nephrology, Huashan Hospital, Fudan University, Shanghai, China College of Chemistry; Chemical Engineering; and Environmental Engineering; Liaoning Shihua University; Fushun 113001 Jilin Province Key Laboratory of Organic Functional Molecular Design & Synthesis, Department of Chemistry, Northeast Normal University, Changchun 130024, China; State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032, China Institute for Advanced Study, Chengdu University, Chengdu 610106, P. R. China Department of Colorectal Surgery, Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Hangzhou, Zhejiang, China (mainland) St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065; Department of Dermatology, Shenzhen University General Hospital, Shenzhen University, Shenzhen, Guangdong 518060, P.R. China Department of Hematology, The First Affiliated Hospital of Harbin Medical University, Harbin, People’s Republic of China Jilin Province Key Laboratory of Organic Functional Molecular Design & Synthesis Department of Chemistry Northeast Normal University Changchun 130024 China Department of Infectious Diseases, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China (mainland) School of Biomedical Science, Institutes of Molecular Medicine, Huaqiao University, Quanzhou 362021, China. Department of Pharmaceutical Analysis, School of Pharmacy, Hebei Medical University , 361 East Zhongshan Road, Shijiazhuang, Hebei , PR China Department of Gene, Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 100052, China. zq781116@126.com Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China; China National Clinical Research Center for Neurological Diseases, Beijing, China; Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China; Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China Department of Environmental Science and Engineering, Huaqiao University, Xiamen 361021, China Department of Neurology, Hainan Hospital of Chinese People’s Liberation Army General Hospital, Sanya, China First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan, China Department of Ophthalmology, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China Department of Chemistry, Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Tsinghua University, Beijing 100084, People's Republic of China Polymer High Functional Film Engineering Research Center of Liaoning Province, Shenyang University of Chemical Technology, Shenyang 110142, China; College of Materials Science and Engineering, Shenyang University of Chemical Technology, Shenyang 110142, China Genelux Corporation, San Diego Science Center, San Diego, CA 92109.; Department of Radiation Oncology, Rebecca and John Moores Comprehensive Cancer Center, University of California, San Diego, CA 92093. Department of Health and Exercise Science, Colorado State University , Fort Collins, Colorado , USA Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104; National Health Commission Key Laboratory of Antibody Techniques, Department of Cell Biology, Jiangsu Provincial Key Laboratory of Human Functional Genomics, School of Basic Medical Sciences, Nanjing Medical University , Nanjing, Jiangsu , China; Institute for Brain Tumors, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Personalized Cancer Medicine, Nanjing Medical University , Nanjing, Jiangsu , China Molecular Oncology Laboratory, Department of Orthopaedic Surgery and Rehabilitation Medicine, The University of Chicago Medical Center, Chicago, IL, USA; Department of Orthopaedic Surgery, the First Affiliated Hospital, and Ministry of Education Key Laboratory of Diagnostic Medicine and the Affiliated Hospitals of Chongqing Medical University, Chongqing, China School of Pharmacy; China Pharmaceutical University; Nanjing; China College of Pharmacy, Inner Mongolia Medical University , Hohhot, China Key Laboratory of Molecular Pharmacology and Drug Evaluation, Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, School of Pharmacy, Yantai University, Yantai, Shandong 264005, P.R. China Key Laboratory of Antibody Techniques of Ministry of Health, Nanjing Medical University, Nanjing, Jiangsu Province, P.R. China. Department of Endocrinology, Key Laboratory of Endocrinology, National Health and Family Planning Commission, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College (CAMS & PUMC), Beijing, P.R. China Huaxi MR Research Center, Department of Radiology, West China Hospital of Sichuan University, Chengdu, Sichuan, China; Research Unit of Psychoradiology, Chinese Academy of Medical Sciences, Chengdu, Sichuan, China Department of Cardiovascular Surgery Provincial Hospital Affiliated to Shandong University, Shandong University Jinan Shandong Province China Hubei Provincial Key Laboratory of Green Materials for Light Industry; Hubei University of Technology; Wuhan 430068; China Department of Epidemiology, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China. Department of Traumatic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jie Fang Avenue 1095, Wuhan Department of Chemical Physiology, The Scripps Research Institute, La Jolla, United States; Department of Cell and Molecular Biology, The Scripps Research Institute, La Jolla, United States Department of Dermatology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China Department of Science and Technology, Anhui University of CM, Hefei 230012, China. Affiliated Zhongshan Hospital of Dalian University; No. 6 Jiefang Street Dalian 116001 Liaoning China Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi; and; Department of Cardiac Surgery, Provincial Hospital Affiliated to Shandong University, Jinan, China Department of Dermatology, Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Nanjing, Jiangsu Province, China Department of Chemistry and Biochemistry, University of Maryland College Park, Maryland 20742, United States Department of Medicinal Chemistry, School of Pharmacy, Fudan University, Shanghai 201203, China School of Chemistry Engineering and Materials Science Heilongjiang University 74 Xuefu Road Nangang District Harbin China 150080 Key Laboratory of Synthetic Rubber, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation; Southwest Petroleum University; Chengdu 610500; China; The Center of New Energy Materials and Technology Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, Liaoning Province, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China Central Laboratory Peking University School and Hospital of Stomatology Beijing China Teaching and Research Section of Surgery, Xiangnan University Affiliated Hospital, Chenzhou, Hunan 423000, P.R. China State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangdong Key Laboratory of Vascular Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China; Division of Translational and Regenerative Medicine, Tucson, Arizona; Department of Medicine, The University of Arizona College of Medicine, Tucson, Arizona; Department of Physiology, The University of Arizona College of Medicine, Tucson, Arizona Institute of Nano Biomedicine and Engineering, Shanghai Engineering Research Center for Intelligent Diagnosis and Treatment Instrument, Department of Instrument Science and Engineering, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, 800 Dongchuan RD, Shanghai 200240, P.R. China; National Engineering Center for Nanotechnology, Collaborative Innovational Center for System Biology, 28 Jiangchuan Road, Shanghai 200241, P.R. China School of Materials and Chemical Engineering, Hubei University of Technology, Wuhan 430068, China Heller School of Social Policy and Management, Brandeis University, Waltham, Massachusetts. Pharmacokinetics, Pharmacodynamics & Drug Metabolism, Merck & Co., Inc., West Point, PA 19486, USA Department of Obstetrics and Gynecology,the First Affiliated Hospital of Xi'anJiaotong University,Xi'an 710061,China. Department of Endocrinology Key Laboratory of Endocrinology Ministry of Health Peking Union Medical College Hospital Diabetes Research Center of Chinese Academy of Medical Sciences & Peking Union Medical College Beijing China State Key Laboratory of Quality Research in Chinese Medicine, Faculty of Chinese Medicine, Macau University of Science and Technology, Macao, P.R. China Central Laboratory, Peking University School and Hospital of Stomatology, Beijing, China Department of Pharmacology and Chemical Biology Shanghai Universities Collaborative Innovation Center for Translational Medicine Shanghai Jiao Tong University School of Medicine Shanghai 200025 China Department of Intensive Care Unit (ICU), The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei Internal Medicine Residency Program, Rochester General Hospital, Rochester, New York, New York, USA; School of Environmental Science and Technology, Key Laboratory of Industrial Ecology and Environmental Engineering (Ministry of Education), Dalian University of Technology, Dalian POCT Laboratory, Dalian, 116024, China Center for Reproductive Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, 200135 Shanghai, China;; Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, 200135 Shanghai, China;; Center for Reproductive Medicine, Shandong University, 250021 Jinan, China;; National Research Center for Assisted Reproductive Technology and Reproductive Genetics, 250021 Jinan, China; Neonatal Intensive Care Unit, First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China. jsbwn@yahoo.com.cn Authors' Affiliations: 1Eppley Institute for Research in Cancer and Allied Diseases and 2Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska; and 3Department of Cancer Biology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania MOA Key Laboratory of Pest Monitoring and Green Management, Department of Plant Pathology, College of Plant Protection China Agricultural University Beijing 100193 China Key Laboratory of Genetics and Biotechnology, College of Life Science, Capital Normal University, Beijing 100037, China and; State Agriculture Biotechnology Centre, Western Australian Department of Agriculture and Food, Murdoch University, Perth, Western Australia 6150, Australia National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. Kidney Disease Center the First Affiliated Hospital Zhejiang University School of Medicine Hangzhou China Department of Cardiology, The General Hospital of Western Theater Command, Chengdu 610083, Sichuan, China Department of Chemistry, Xi’an-Jiaotong Liverpool University, 215123 Suzhou, China; Department of Chemistry, University of Liverpool, Liverpool L69 7ZD, United Kingdom Department of Obstetrics and Gynaecology, Shanghai Eighth Hospital, Shanghai, China Department of Chemistry; Northeast Normal University; Changchun 130024; China Department of General Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, P. R. China Department of Thoracic Surgery Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research & The Affiliated Cancer Hospital of Nanjing Medical University Nanjing China Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing;; China National Clinical Research Center for Neurological Diseases, Beijing; and; Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China Interventional Center of Valvular Heart Disease Beijing Anzhen Hospital, Capital Medical University, Beijing, China Department of Ultrasound, Xi'an Children Hospital, Xi'an 710003, Shaanxi Province, China Research Institute of Medical Genetics, Zhengzhou University People's Hospital / People's Hospital of Henan Province, Zhengzhou, Henan 450003, China. Department of Chemistry Fudan University Shanghai 200433 P. R. China Department of Respiratory Medicine, Affiliated Changzhou Second Hospital of Nanjing Medical University, Changzhou, Jiangsu 213000, P.R. China Department of Noncommunicable Disease Control and Prevention, Zibo Center for Disease Control and Prevention, Zibo, Shandong Province, PR China; Department of Medicinal Chemistry Key Laboratory of Chemical Biology (Ministry of Education) School of Pharmaceutical Sciences Shandong University Jinan Shandong China School of Materials Science and Engineering; Jiangxi Provincial Key Laboratory of Power Batteries and Materials; Jiangxi University of Sciences and Technology; Ganzhou 341000; China Key Lab of Bioelectrochemistry & Environmental Analysis of Gansu; College of Chemistry and Chemical Engineering; Northwest Normal University; Lanzhou 730070; P. R. China Institute of Drug Metabolism and Drug Analysis College of Pharmaceutical Sciences Zhejiang University Hangzhou 310058 China Department of Neurobiology, Fourth Military Medical University, Xi'an 710032, China. Department of Geriatrics, the third Hospital of Hebei Medical University, Shijiazhuang, Hebei, China Department of Pharmacology School of Medicine Nanjing University of Chinese Medicine Nanjing 210023 China Laboratory of Biology and Genetic Improvement of Oil Crops, Oil Crops Research Institute of the Chines Academy of Agricultural Sciences, Ministry of Agriculture and Rural Affairs, Wuhan 430062, China Department of Dermatology , Jinan Central Hospital affiliated to Shandong University , Jinan 250013, Shandong Province , P.R. China Research Informatics, BC Children’s Hospital Research Institute, Vancouver, BC, Canada Center for High Pressure Science and Technology Advanced Research, Shanghai 201203, People’s Republic of China Key Laboratory of Bio-Resources and Eco-Environment, Ministry of Education and College of Life Sciences, Sichuan University, Chengdu 610065, P.R. China Central Laboratory, Peking University School and Hospital of Stomatology, No. 22, Zhongguancun South Avenue, Haidian District, Beijing 100081, P. R. China Department of Hematology, The First Affiliated Hospital of Nanchang University; Institute of Hematology, Academy of Clinical Medicine of Jiangxi Province, Nanchang 330006, Jiangxi Province, China. Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, 119 South Fourth Ring West Road, Fengtai District, Beijing 100070, China; China National Clinical Research Center for Neurological Diseases, Beijing 100070, China; Center of Stroke, Beijing Institute for Brain Disorders, Beijing 100070, China; Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing 100070, China; Beijing Translational Engineering Center for 3D Printer in Clinical Neuroscience, Beijing 100070, China Department of Radiation Oncology, Zhongshan Hospital, Fudan University, Shanghai, China “State Key Laboratory of Food Nutrition and Safety”, Key Laboratory of Food Nutrition and Safety, Ministry of Education, College of Food Engineering and Biotechnology, Tianjin University of Science and Technology, No. 29, 13th Avenue, Tianjin Economy Technological Development Area, Tianjin, 300457, People Republic of China Department of Obstetrics, Henan Provincial People's Hospital; People's Hospital of Zhengzhou University, Zhengzhou, Henan, 450003, China Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering; Feringa Nobel Prize Scientist Joint Research Center; School of Chemistry and Molecular Engineering; East China University of Science & Technology; Shanghai Institute of Grassland Research of CAAS, Chinese Academy of Agricultural Sciences, Hohhot, China School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation, Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai, Shandong 264003, P.R. China Department of Psychology, Shandong Normal University, Key Laboratory of Human Cognition and Behavioural Development of Shandong High School, Jinan, China School of Materials, Shenzhen Campus of Sun Yat-sen University, No. 66, Gongchang Road, Guangming District, Shenzhen, Guangdong 518107, China Key Laboratory of Sensor Analysis of Tumor Marker, Ministry of Education; Shandong Key Laboratory of Biochemical Analysis; Key Laboratory of Analytical Chemistry for Life Science in Universities of Shandong; College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, P. R. China Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM, Necker Hospital for Sick Children 75015 Paris, France;; Imagine Institute, University of Paris, Paris 75015, France;; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065; College of Pharmacy; Ningxia Medical University; Yinchuan 750004; China; Key Laboratory of Ningxia Ethnomedicine Modernization Physikalische und Theoretische Chemie, Freie Universität Berlin, D-14195 Berlin, Germany State Key Laboratory of Catalysis Dalian Institute of Chemical Physics, Chinese Academy of Sciences NO. 457, Zhongshan Road Dalian 116023 PR China Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University , Chengdu 610041, Sichuan , P.R. China; Research Unit of Psychoradiology, Chinese Academy of Medical Sciences , Chengdu 610041, Sichuan , P.R. China; Functional and Molecular Imaging Key Laboratory, Sichuan University , Chengdu 610041, Sichuan , P.R. China Department of Endocrinology, Key Laboratory of Endocrinology, National Health and Family Planning Commission, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Department of Systems Biology for Medicine, School of Basic Medical Sciences, and Institutes of Biomedical Sciences, Fudan University, Shanghai, China Department of Science and Technology Office, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong, People’s Republic of China Center Laboratory, Peking University Hospital of Stomatology, Haidian, Beijing 100081, P.R. China Chinese Academy of Agricultural Sciences, Lanzhou Institute of Husbandry and Pharmaceutical Sciences , Lanzhou, China Department of Cardiology, Xuzhou Central Hospital, Xuzhou, China State Key Laboratory of Natural Medicines; Department of Natural Medicinal Chemistry; China Pharmaceutical University; Nanjing 210009; PR China Department of Dermatology Xijing Hospital Fourth Military Medical University Xi'an China Department of Neurology Bishan Hospital of Chongqing Medical University Chongqing China School of Mathematics and Statistics, Guizhou University, Guiyang 550025, China Department of Hematology, Peking University Shenzhen Hospital, Shenzhen, Guangdong Province, China. School of Life Sciences and Technology, Xidian University, Shaanxi, Xi’an 710071, China State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, China; Key Laboratory of Aquaculture Diseases Control, Ministry of Agriculture, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, China; University of Chinese Academy of Sciences, Beijing, China School of Ecological and Environmental Sciences Tiantong National Station of Forest Ecosystem East China Normal University Shanghai 200241 China Center for High Pressure Science and Technology Advanced Research (HPSTAR) Beijing 100194 P. R. China Department of Biomaterials, College of Materials Xiamen University Xiamen 361005 China Institutes of Advanced Technology Zhengzhou University Zhengzhou 450052 P. R. China Department of Gastroenterology Affiliated Hospital of Qingdao University Qingdao China Center for Reproductive Medicine, Shandong University , Jinan 250012, Shandong , China; Key Laboratory of Reproductive Endocrinology of Ministry of Education, Shandong University , Jinan 250012, Shandong , China; Shandong Key Laboratory of Reproductive Medicine , Jinan 250012, Shandong , China; Shandong Provincial Clinical Research Center for Reproductive Health , Jinan 250012, Shandong , China; Shandong Technology Innovation Center for Reproductive Health , Jinan 250012, Shandong , China; National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University , Jinan 250012, Shandong , China Department of Materials Science and Engineering, Harbin Institute of Technology, Guangdong, 518055 Shenzhen, China; School of Chemistry and Chemical Engineering, the State Key Laboratory of Metal Matrix Composites, Shanghai Jiao Tong University, Shanghai 200240, P.R. China Department of Chemistry; College of Chemistry and Chemical Engineering; MOE Key Laboratory of Spectrochemical Analysis and Instrumentation; and Collaborative Innovation Center of Chemistry for Energy Materials (iChEM); Xiamen University School of Materials Science and Engineering, and Institute of Materials Genome & Big Data Harbin Institute of Technology (Shenzhen) Shenzhen 518055 China College of Pharmaceutical Sciences Hebei University Baoding P. R. China Institute of Bio- and Geosciences, Agrosphere (IBG-3), Forschungszentrum Jülich GmbH, 52425 Jülich, Germany; Institute for Environmental Research, Biology 5, RWTH Aachen University, Worringerweg 1, 52074 Aachen, Germany Key Laboratory of Material Chemistry for Energy Conversion and Storage (Huazhong University of Science and Technology), Ministry of Education, Hubei Key Laboratory of Material Chemistry and Service Failure, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan 430074, P. R. China Department of Chemistry, Northeast Normal University, Changchun 130024, China Key Laboratory of Marine Eco-Environmental Science and Technology, First Institute of Oceanography, MNR , Qingdao 266061 , China Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, 294 Taiyuan Road, Shanghai 200031, China NIAID Clinical Genomics Program, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.; Human Immunological Diseases Unit, Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. CAS Key Laboratory of Soft Matter Chemistry, Department of Chemistry, University of Science and Technology of China, Hefei, Anhui, 230026, People’s Republic of China Department of Pathology, State Key Laboratory of Biotherapy, and Collaborative Innovation Centre of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China; Sichuan Institute of Edible Fungi, Chengdu 610066, China Medical Research Center The Affiliated Hospital of Qingdao University Qingdao China Department of Urology Peking University First Hospital Beijing China; Institute of Urology Peking University Beijing China; National Urological Cancer Center Beijing China; Beijing Key Laboratory of Urogenital Diseases (male) Molecular Diagnosis and Treatment Center Beijing China Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China; Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China; Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China; China National Clinical Research Center for Neurological Diseases, Beijing, China Center for Eukaryotic Gene Regulation, and; Departments of bBiochemistry and Molecular Biology, Department of Laboratory Medicine Zhongnan Hospital of Wuhan University Wuhan 430071 China; Center for Single‐Cell Omics and Tumor Liquid Biopsy Zhongnan Hospital of Wuhan University Wuhan 430071 China Chengdu Chipscreen Pharmaceutical Ltd., Chengdu 610213, China Department of Emergency, Xiangyang Central Hospital, Xiangyang, Hubei 441032, P.R. China Qian Zhang, Department of Infectious Diseases, Changhai Hospital, Second Military Medical University, Shanghai 200433, China. School of Medicine, Guizhou University, Guiyang 550025, China; State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Beijing Key Laboratory of Carcinogenesis and Translational Research, NMPA Key Laboratory for Research and Evaluation of Radiopharmaceuticals (National Medical Products Administration), Department of Nuclear Medicine, Peking University Cancer Hospital & Institute, Beijing 100142, China Research Center for Molecular Recognition and Synthesis Department of Chemistry Fudan University 220 Handan Lu Shanghai 200433 P. R. China Department of Cell Biology and Genetics, State Key Laboratory of Medicinal Chemical Biology, 2011 Collaborative Innovation Center for Biotherapy, College of Life Sciences, Nankai University, Tianjin, China Jiangxi Provincial Key Laboratory of Drug Design and Evaluation, School of Pharmacy, Jiangxi Science & Technology Normal University, 605 Fenglin Road, Nanchang, Jiangxi 330013, China Law Enforcement and Supervision Bureau of Shandong Provincial Health Commission, Ji’nan, Shandong, China Institute of Liver Diseases,Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai,China Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, USA Department of Anesthesiology, The Third Affiliated Hospital of Shandong First Medical University, Jinan, 250031 Shandong, China Department of Physics, Boston College, Chestnut Hill, Massachusetts 02467, United States CAS Key Laboratory of Science and Technology on Applied Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China; University of Chinese Academy of Sciences, Beijing 100049, China Central Laboratory Peking University School and Hospital of Stomatology Beijing P. R. China Department of Chemistry Fudan University Shanghai 200433 P.R. China School of Dentistry, Hospital of Stomatology, Tianjin Medical University, Tianjin 300070, China College of Chemistry, Chemical Engineering and Resource Utilization, Northeast Forestry University, Harbin, Heilongjiang, China; Key Laboratory of Forest Plant Ecology, Northeast Forestry University, Ministry of Education, Harbin, Heilongjiang, China Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals; Key Laboratory of Green Chemical Media and Reactions; Ministry of Education; School of Chemistry and Chemical Engineering; Henan Normal University Guangdong Provincial Key Laboratory of Silviculture, Protection and Utilization/Guangdong Academy of Forestry, Guangzhou, China; School of Environmental & Municipal Engineering, Xi’an University of Architecture and Technology, Xi’an, Shaanxi, China College of Bioscience and Biotechnology Shenyang Agricultural University Shenyang Liaoning China The Key Laboratory of Functional Polymer Materials and Center for Nanoscale Science and Technology, Institute of Polymer Chemistry, College of Chemistry, Nankai University, Tianjin 300071, China School of Pharmacy, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Yantai University, Yantai, P. R. China Key Laboratory of Exploration and Utilization of Aquatic Genetic Resources, Shanghai Ocean University, Ministry of Education, Shanghai, China; The MOE Key Laboratory for Standardization of Chinese Medicines and the SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica Shanghai University of Traditional Chinese Medicine 1200 Cailun Road Shanghai 201210 China; Shanghai R&D Centre for Standardization of Chinese Medicines 199 Guoshoujing Road Shanghai 201210 China Key Laboratory of Endocrinology; Translational Medicine Center; Ministry of Health; Department of Endocrinology; Peking Union Medical College Hospital Department of Endocrinology, The First Medical Center of Chinese PLA General Hospital , Beijing , China Division of Advanced Manufacturing, Tsinghua Shenzhen International Graduate School, Shenzhen 518055, China; State Key Laboratory of Precision Measurement Technology and Instruments, Department of Precision Instrument, Tsinghua University, Beijing 100084, China Department of Endocrinology, Key Laboratory of Endocrinology, National Health Commission, Peking Union Medical College Hospital Peking Union Medical College Chinese Academy of Medical Sciences Beijing China Department of Emergency, Guizhou Provincial People’s Hospital, Guizhou, China Department of Neurosurgery, The Fifth Medical Center, Chinese PLA General Hospital, Beijing, China Department of Biochemistry and Molecular Biology, Tulane University School of Medicine, New Orleans, LA 70112 Laboratory of Animal Cell Biology and Embryology College of Veterinary Medicine Nanjing Agricultural University Nanjing Jiangsu 210095 China Ministry of Education Key Laboratory of Agricultural Soil and Water Engineering in Arid and Semiarid Areas, Northwest A&F University, Yangling 712100, Shaanxi, China. Institute of Water-saving Agriculture in Arid Areas of China, Northwest A&F University, Yangling 712100, Shaanxi, China. School of Public Health Jilin University Changchun Jilin Province China Department of Respiration Tangdu Hospital Fourth Military Medical University Xi'an China School of Materials Science and Engineering, and Institute of Materials Genome & Big Data Harbin Institute of Technology Shenzhen 518055 China Department of The First of Internal Medicine Shaanxi Provincial Cancer Hospital Xi'an Shannxi People's Republic of China Department of Ultrasonic Imaging, Wuhan Fourth Hospital, Wuhan, Hubei, China College of Physics and Engineering; Henan University of Science and Technology; Luoyang 471023; People's Republic of China School of Nursing, Lanzhou University, Lanzhou, China. Department of Hand Surgery Wuxi 9th People's Hospital Affiliated to Soochow University Wuxi 214062 China Qingshan District Center for Disease Control and Prevention, Wuhan, People’s Republic of China Department of Cardiology Southwest Hospital, Third Military Medical University Chongqing 400038 China School of Chemistry and Chemical Engineering, the State Key Laboratory of Metal Matrix Composites, Shanghai Jiao Tong University, Shanghai 200240, China Department of Pharmaceutical Analysis, School of Pharmacy Hebei Medical University Shijiazhuang Hebei China National Cancer Center ‐ Cancer Hospital Chinese Academy of Medical Sciences (CAMS) & Peking Union Medical College (PUMC) Beijing China Departments of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA; Department of Anatomy Dalian Medical University Dalian Liaoning Province China State Key Laboratory of Physical Chemistry of Solid Surfaces, Collaborative Innovation Center of Chemistry for Energy Materials, Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, People's Republic of China State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences Fuzhou, Fujian China; Xiamen Key Laboratory of Rare Earth Photoelectric Functional Materials Xiamen Institute of Rare Earth Materials, Haixi Institute Chinese Academy of Sciences Xiamen, Fujian 361021 China Key Laboratory of Optic-electric Sensing and Analytical Chemistry for Life Science; MOE; Shandong Key Laboratory of Biochemical Analysis; Key Laboratory of Analytical Chemistry for Life Science in Universities of Shandong; College of Chemistry and Molecular Engineering. Qingdao University of Science and Technology; Qingdao 266042; PR China Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China; China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, P.R. China Laboratory of Advanced Materials & Department of Chemistry, Fudan University, 2005 Songhu Road, Shanghai 200438, P. R. China Key Laboratory of Biomaterials of Guangdong Higher Education Institutes Engineering Technology Research Center of Drug Carrier of Guangdong Department of Biomedical Engineering Jinan University Guangzhou 510632 China Key Laboratory of Nutrition and Metabolism Institute for Nutritional Sciences Shanghai Institutes for Biological Sciences Chinese Academy of Sciences The Graduate School of the Chinese Academy of Sciences Shanghai China Department of Chemistry, The University of Texas at Austin, 105 East 24th Street, Austin, Texas 78712, United States Jilin Province Key Laboratory of Functional Organic Molecule Design & Synthesis; Department of Chemistry; Northeast Normal University; Changchun; P. R. China State Key Laboratory of Cotton Biology Key Laboratory of Plant Stress Biology College of Life Sciences Henan University Kaifeng 475004 China State Key Laboratory of Explosion Science and Technology, Beijing Institute of Technology, No. 5, Zhongguancun South Street, Haidian District, Beijing 100081, China Graduate School of Tianjin Medical University Tianjin China Institute of Nutrition and Food Safety, Chinese Center for Disease Control and Prevention, Beijing 100050, China. zhangq-99@263.net School of Materials Science and Engineering Jiangxi Provincial Key Laboratory of Power Batteries and Materials Jiangxi University of Sciences and Technology Ganzhou 341000 P. R. China Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, Beijing 100083, China Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, National Clinical Research Center for Digestive Diseases, Beijing 100050, China State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi International Joint Research Center for Oral Diseases, Department of General Dentistry and Emergency, School of Stomatology, Air Force Medical University, Xi’an, PR China. Department of Hematology, Lanzhou General Hospital of Lanzhou Military Commond, Lanzhou 730050, Gansu Province, China. E-mail: zhangqxyk2006@163.com. Jiangxi Key Laboratory of Power Batteries and Materials, Faculty of Materials Metallurgy and Chemistry, Jiangxi University of Sciences and Technology, Ganzhou 341000, China; Yichun Lithium New Energy Industry Research Institute, Jiangxi University of Science and Technology, Ganzhou 341000, China Department of Laboratory Medicine, The First Affiliated Hospital of China Medical University, Shenyang, China. Key Laboratory of Functional Organic Molecule Design & Synthesis of Jilin Province, Department of Chemistry, Northeast Normal University, Changchun 130024, China Department of Urology, Peking University First Hospital, Beijing 100034, China. College of Food and Biological Engineering, Jimei University, Xiamen, Fujian 361021, China Department of General Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, PR China; The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, PR China College of Life Sciences, Jilin Agricultural University, Changchun 130118, China Hefei National Research Center for Physical Sciences at the Microscale University of Science and Technology of China Hefei Anhui 230026 China; Department of Applied Chemistry University of Science and Technology of China Hefei Anhui 230026 China Center for Hypertension and Metabolic Diseases Department of Hypertension and Endocrinology Chongqing Institute of Hypertension Daping Hospital Army Medical University Chongqing PR China Department of Botany University of British Columbia Vancouver BC Canada Institute of Pathogenic Biology, Shenzhen Center for Disease Control and Prevention, Shenzhen, China. Department of Respiratory Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China Department of Geriatrics Intensive Care Unit, The First Affiliated Hospital of Nanjing Medical University (Jiangsu Province People’s Hospital), Nanjing 210029, Jiangsu Province, China Modern Research Center for Traditional Chinese Medicine Beijing University of Chinese Medicine Beijing 100029 China State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing 210023, China Sichuan Institute of Edible Fungi, Chengdu 610066, China; National-Local Joint Engineering Laboratory of Breeding and Cultivation of Edible and Medicinal Fungi, Chengdu 610066, China; Scientific Observing and Experimental Station of Agro-Microbial Resource and Utilization in Southwest China, Ministry of Agriculture, Chengdu 610066, China Laboratory of Animal Anatomy & Tissue Embryology, Department of Basic Veterinary Medicine, Faculty of Veterinary Medicine, Gansu Agricultural University, Lanzhou 730070, China Department of Internal Medicine One, Shaanxi Provincial Cancer Hospital, College of Medicine, Xi’an Jiaotong University, Shaanxi, Xi’an 710061, China Neonatology Department, Cang Zhou Women and Children’s Healthcare Hospital, Cangzhou, Hebei 061000, China From the Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China (Q.Z., Y.Z., C.W., S.Z., A.W., N.L., L.B., J.W., Q.J., X.Z.); Department of Cell Transplantation, the General Hospital of Chinese People’s Armed Police Forces, Beijing, China (Q.Z.); Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital, and Harvard Medical School, Boston, MA (X.G.); Department of Nutrition, Harvard University School of Public Health, Boston, MA (X.G.);... Translational Medicine Centre, Honghui Hospital, Xi’an Jiaotong University, Xi’an, Shannxi, People’s Republic of China Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI, USA. Nanjing University of Chinese Medicine， Chinese Medicine Resources Industrialization Process Collaborative Innovation Center of Jiangsu Province, Nanjing 210023, China. Key Laboratory of Industrial Ecology and Environmental Engineering (MOE) School of Environmental Science and Technology Dalian University of Technology Dalian China College of Chemistry, Chemical Engineering and Materials Science, Shandong Normal University, Jinan 250014, China Sanitary Inspection Institute, Tianjin Centers for Disease Control and Prevention, Tianjin, PR China School of Materials and Chemical Engineering; Hubei University of Technology; Wuhan 430068; China; Hubei Key Laboratory of Drug Synthesis and Optimization Center of Reproductive Medicine General Hospital of Northern Theater Command Shenyang China Center for Coronary Heart Disease, Department of Cardiology, Cardiovascular Institute and Fuwai Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences Evidence-Based Nursing Center, School of Nursing, Lanzhou University, Lanzhou, China Department of Chemistry and Biochemistry, University of Maryland, College Park, Maryland 20892, United States Advanced Technology and Cancer Research, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, Illinois 60064-6202 Department of NeurologyBeijing Tiantan Hospital, Capital Medical University, Beijing, China; Department of Cell Transplantationthe General Hospital of Chinese People's Armed Police Forces, Beijing, China Department of Forest Resources and Environmental Conservation Virginia Polytechnic Institute and State University Blacksburg Virginia USA Biotechnology Research Institute, Chinese Academy of Agricultural Sciences/National Key Facility for Gene Resources and Genetic Improvement, Beijing 100081, China (Q.Z., J.W., Z.Z., T.L.) Kampo Research Laboratories, Kracie Pharma, Ltd. Key Laboratory of Industrial Ecology and Environmental Engineering (MOE); School of Environmental Science and Technology; Dalian University of Technology; Dalian 116024; China College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Jiangsu 215123, China Department of Geriatrics Intensive Care Unit, the First Affiliated Hospital of Nanjing Medical University, Nanjing, People's Republic of China Department of Laboratory Medicine , Peking University Third Hospital , Beijing , P.R. China School of Environmental and Chemical Engineering Shanghai University 99 Shangda Road Shanghai 200444 P. R. China Department of Epidemiology; National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College; Beijing China School of Textile and Clothing, Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-innovation Center of Neuroregeneration, Nantong University, Nantong, 226001, China Department of Physiology, School of Basic Medical Sciences, Nanjing Medical University, Nanjing, 211166, China. Graduate School, Anhui University of CM, Hefei 230012, China. Key Laboratory of Aerosol Chemistry and Physics, Institute of Earth Environment, Chinese Academy of Sciences, Xi’an 710061, China Molecular Oncology Laboratory, Department of Orthopaedic Surgery, The University of Chicago Medical Center, Chicago, Illinois.; Ministry of Education Key Laboratory of Diagnostic Medicine, and The Affiliated Hospitals of Chongqing Medical University, Chongqing, China. Jilin Province Key Laboratory of Functional Organic Molecule Design & Synthesis, Department of Chemistry, Northeast Normal University, Changchun, Jilin 130024, China Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University;; Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease; and The Third Central Clinical College of Tianjin Medical University Tianjin China; Department of Hepatology Tianjin Third Central Hospital Tianjin China Jilin Province Key Laboratory of Organic Functional Molecular Design & Synthesis and Institute of Functional Material Chemistry Department of Chemistry Northeast Normal University Changchun 130024 P. R. China Life Sciences Institute and Innovation Center for Cell Signaling Network, Zhejiang University, Hangzhou, 310058, China Minhang Hospital and Institutes of Biomedical Sciences, Fudan University, Shanghai 201199, China Tianjin Key Laboratory of Organic Solar Cells and Photochemical Conversion, Tianjin Key Laboratory of Drug Targeting and Bioimaging, School of Chemistry and Chemical Engineering, Tianjin University of Technology, Tianjin 300384, People’s Republic of China Department of Hematology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, Shandong Province, China. Department of Colorectal Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150086, P.R. China State Key Laboratory of Luminescent Materials and Devices and Institute of Polymer Optoelectronic Materials and Devices, South China University of Technology, Guangzhou 510640, China Key Laboratory of Textile Science & Technology, Ministry of Education, College of Textiles, Donghua University, Shanghai 201620, China School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China. Department of Clinical Pharmacology Affiliated Hospital of Nanjing University of Traditional Chinese Medicine Nanjing China Department of critical medicine the First Affiliated Hospital of Guizhou Medical School Guiyang Guizhou China Department of Rehabilitation, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China (mainland) School of Materials and Chemical Engineering, Henan University of Engineering, Zhengzhou, Henan 451191, China Department of Respiratory Medicine, Affiliated Changzhou No.2 People's Hospital, Nanjing Medical University, Changzhou 213003, P.R. China Department of Hematology, Lanzhou Military Command General Hospital,Lanzhou 730050, Gansu Province, China. E-mail: zhangqxyk2006@163.com. Center for Reproductive Medicine Shandong University Jinan Shandong China; Key Laboratory of Reproductive Endocrinology of Ministry of Education Shandong University Jinan Shandong China; Shandong Key Laboratory of Reproductive Medicine Jinan Shandong China; Shandong Provincial Clinical Research Center for Reproductive Health Jinan Shandong China Biotechnology Research Institute Chinese Academy of Agricultural Sciences Beijing 100081 China Center for High Pressure Science and Technology Advanced Research Shanghai 201203 China; School of Materials and Chemical Engineering Zhongyuan University of Technology Zhengzhou 451191 China Department of Biotechnology Dalian Medical University Dalian 116044 China School of Pharmaceutical Sciences and School of Traditional Chinese Medicine Southern Medical University Guangzhou 510515 China; State Key Laboratory for Quality Ensurance and Sustainable Use of Dao‐di Herbs Artemisinin Research Center, and Institute of Chinese Materia Medica China Academy of Chinese Medical Sciences Beijing 100700 China Suzhou Key Laboratory of Nanotechnology and Biomedicine, Institute of Functional Nano and Soft Materials (FUNSOM) and Collaborative Innovation Center of Suzhou Nano Science and Technology (NANO-CIC), Soochow University, Suzhou 215123, China Department of Reproductive Medicine, General Hospital of Northern Theater Command, Shenyang, Liaoning province, PR. China Neonatal Intensive Care Unit The First Affiliated Hospital of Zhengzhou University Zhengzhou City Henan Province China Department of Colorectal Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150086, PR China; Colorectal Cancer Institute of Harbin Medical University, Harbin, Heilongjiang 150086, PR China Department of Chemistry and Biochemistry, Florida State University, 32306, Tallahassee, FL, USA Weifang Key Laboratory of Green Processing of Separator for Chemical Power Sources School of Chemistry and Engineering Weifang Vocational College Weifang 261108 Shandong China State Key Laboratory of Silicate Materials for Architectures, Wuhan University of Technology, Wuhan 430070, China From the Department of Neurology, University of Southern California School of Medicine, Los Angeles, CA, and Southern California Alzheimer Disease Diagnostic and Treatment Center, Downey, CA. Unit of Cell Biology and Imaging Study of Pathogen Host Interaction, The Center for Microbes, Development and Health, Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, China. Chinese PLA Department of Clinical Laboratory Medicine and Chinese PLA General Hospital, Medical School of Chinese PLA, Beijing 100853, P.R. China Ophthalmology Department, First affiliated hospital of Kunming Medical University, Kunming School of Chemistry and Material Science, Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials, Jiangsu Normal University, Xuzhou 221116, China Department of Neonatal Intensive Care Unit; The First Affiliated Hospital of Zhengzhou University; Zhengzhou China Department of Obstetrics Qingdao Municipal Hospital Qingdao P.R. China College of Food and Biological Engineering Chengdu University Chengdu China Department of Forest Resources and Environmental Conservation Virginia Tech Blacksburg VA USA Department of Chemistry and Biochemistry, University of Maryland, College Park, Maryland 20742, United States Shandong Provincial Key Laboratory of Chemical Energy Storage and Novel Cell Technology, College of Chemistry and Chemical Engineering Liaocheng University 252059 Liaocheng Shandong People's Republic of China Jiangsu Key Laboratory of Oral Diseases Nanjing Medical University Nanjing Jiangsu China Department of Clinical Pathology , Weifang Medical University, Weifang 261053, Shandong Province, CN; Key Lab for Immunology in Universities of Shandong Province , Weifang Medical University, Weifang 261053, Shandong Province, CN Department of Radiology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, 210008, China; Central Laboratory of Stomatology, Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, 210008, China Department of Endocrinology, Key Laboratory of Endocrinology, National Health and Family Planning Commission, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100730 , China School of Psychology, University of Leeds, UK Modern Research Center for Traditional Chinese Medicine, School of Chinese Materia Medica, Beijing University of Chinese Medicine Beijing 100029, China. Department of Orthopedics, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China (mainland) Institute of Pharmacology, Toxicology and Biochemical Pharmaceutics, College of Pharmaceutical Science Zhejiang University Hangzhou 310058 China Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, National Clinical Research Center for Digestive Disease, Beijing Digestive Disease Center, Beijing Key Laboratory for Precancerous Lesion of Digestive Disease, Beijing 100050, China Department of Geriatrics ICU The First Affiliated Hospital of Nanjing Medical University (Jiangsu Province Hospital) Nanjing China Graduate Division, Hebei North University Zhangjiakou City 075000, Hebei Province, China. 1Department of Obstetrics and Gynecology, Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, and State Key Laboratory of Biotherapy, West China Second University Hospital, Sichuan University and Collaborative Innovation Center, Chengdu, P.R. China. The Affiliated Hospital of Qingdao University and Biomedical Sciences Institute of Qingdao University (Qingdao Branch of SJTU Bio-X Institutes), Qingdao University Key Laboratory for Thin Film and Microfabrication Technology of the Ministry of Education Department of Instrument Science and Engineering School of Electronic Information and Electrical Engineering Institute of Nano Biomedicine and Engineering Shanghai Jiao Tong University Shanghai 200240 China 1Department of Endocrinology, NHC Key Laboratory of Endocrinology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China Division of Nephrology Huashan Hospital Fudan University Shanghai China; National Clinical Research Center for Aging and Medicine Huashan Hospital Fudan University Shanghai China Key Laboratory of Functional Polymer Materials Collaborative Innovation Center of Chemical Science and Engineering (Tianjin) Center for Nanoscale Science and Technology Institute of Polymer Chemistry College of Chemistry Nankai University Tianjin 300071 China College of Mechanical and Electrical Engineering, Shihezi University, Shihezi 832000, China; Engineering Research Center for Production Mechanization of Oasis Characteristic Cash Crop, Ministry of Education, Shihezi 832000, China; Xinjiang Production and Construction Corps Key Laboratory of Modern Agricultural Machinery, Shihezi 832000, China Beijing Yinfeng Dingcheng Biological Engineering Technology Ltd., Beijing, 100176, P. R. China. Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, New York 10591, United States Infectious Disease Department IV, Hubei Maternal and Child Health Hospital, Wuhan 430074, PR China; Department of Biotherapy, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438, PR China Key Laboratory of Molecular Imaging; The State Key Laboratory of Management and Control for Complex Systems; Institute of Automation; Chinese Academy of Sciences; Beijing Department of Environmental Science and Engineering; Xi'an Jiaotong University; Xi'an 710049; China Authors' Affiliations: 1Department of Radiation Medicine and Applied Sciences and Center for Advanced Radiotherapy Technologies, University of California San Diego, La Jolla; 2Genelux Corporation, San Diego Science Center, San Diego, California; and 3Rudolph Virchow Center for Experimental Biomedicine, Department of Biochemistry and Institute for Molecular Infection Biology, University of Würzburg, Würzburg, Germany; Authors' Affiliations: 1Department of Radiation Medicine and Applied Sciences and Center for Advanced Radiotherapy Technologies, University of California San Diego, La Jolla; 2Genelux Corporation, San Diego Science Center, San Diego, California; and 3Rudolph Virchow Center for Experimental Biomedicine, Department of Biochemistry and Institute for Molecular Infection Biology, University of Würzburg, Würzburg, Germany Johns Hopkins University, Department of Geography and Environmental Engineering, 3400 North Charles Street, Baltimore, Maryland 21218, United States Laboratory of Green Chemistry and Process, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022 Jilin, People’s Republic of China Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical College, Xuzhou, Jiangsu, China; State Key Laboratory of High Performance Civil Engineering Materials (HPCEM), Jiangsu Sobute New Materials Co. Ltd., Nanjing 211103, Jiangsu, P. R. China Laboratory of Water Pollution Remediation, School of Life and Environmental Sciences, Hangzhou Normal University, Hangzhou 311121, China State Key Laboratory of Quality Research in Chinese Medicine, Faculty of Chinese Medicine, Macau University of Science and Technology, Macao 999078, Macao SAR of P. R. China College of Landscape Architecture Nanjing Forestry University Nanjing 210037 China Department of Plastic and Cosmetic Surgery, Nanfang Hospital Southern Medical University Guangzhou P. R. China CAS Key Laboratory of Genome Sciences and Information Beijing Institute of Genomics Chinese Academy of Sciences Beijing China School of Materials Science and Engineering, the New Style Think Tank of Shaanxi Universities (Research Center for Auxiliary Chemistry and New Materials Development), Shaanxi University of Science and Technology, Xuefu Road, Weiyang District, Xi'an 710021, Shaanxi, P. R. China Hefei National Research Center for Physical Sciences at the Microscale, University of Science and Technology of China, Hefei, Anhui 230026, China.; Department of Applied Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, China. School of Materials Science and Engineering Jiangxi Provincial Key Laboratory of Power Batteries and Materials Jiangxi University of Sciences and Technology Ganzhou 341000 China Department of Hematology, The First Affiliated Hospital, University of Science and Technology of China, Hefei, Anhui 230001, P.R. China Research Institute of Forestry Chinese Academy of Forestry No. 1, Dongxiaofu, Xiangshan Road, Haidian District Beijing 100091 China Department of General Surgery, the First Affiliated Hospital with Nanjing Medical University, Nanjing 210029, China; Graduate School, The First Clinical School of Nanjing Medical University, Nanjing 210029, China The Fifth Affiliated Hospital, Key Laboratory of Molecular Target & Clinical Pharmacology and the State & NMPA Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou, China 1Cancer Institute, Xuzhou Medical University, Xuzhou, Jiangsu, China. Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Science and Peking Union Medical College, 167 Beilishilu, Xicheng District, Beijing 100037, China Northwest Institute of Plateau Biology, Chinese Academy of Sciences, Xining 810008, China School of Civil Engineering and Architecture, Wuhan University of Technology, Wuhan 430070, China. qianzhang@whut.edu.cn Derparterment of Hematology, Anhui Provincial Hospital Affiliated to Anhui Medical University, Hefei 230001, Anhui Province, China. College of Computer Science, Hangzhou Dianzi University , Hangzhou, Zhejiang 310018 , China; Key Laboratory of Intelligent Image Analysis for Sensory and Cognitive Health, Ministry of Industry and Information Technology of China , Hangzhou, Zhejiang 310018 , China Centre for Molecular Microbiology and Infection, Department of Infectious Diseases, Flowers Building, Imperial College London, London SW7 2AZ, United Kingdom College of Forestry, Shanxi Agricultural University, Jinzhong 030801, China School of Basic Medical Sciences, Southwest Medical University, Luzhou, China Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China Department of Laboratory Medicine The First Affiliated Hospital of Henan University Kaifeng China Jiangsu Key Laboratory of Oral Diseases Nanjing Medical University Nanjing Jiangsu People's Republic of China; Suzhou Stomatological Hospital Suzhou Jiangsu People's Republic of China Department of Chemistry; Xi’an-Jiaotong Liverpool University; Suzhou; China; Department of Chemistry Key Laboratory of Endocrinology, Ministry of Health, Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing PR China Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037; Department of Hematology, Lanzhou General Hospital, Lanzhou Military Command, Lanzhou 730050, Gansu Province, China. E-mail: zhangqxyk2006@163.com. Department of Neurosurgery, 307th Hospital of People’s Liberation Army, The Center for Cerebral Vascular Disease, PLA, Beijing, People’s Republic of China From the Division of Cardiovascular Medicine (L.L., Q.Z., V.T., Z.Z., A.A.K., N.C.), Department of Internal Medicine, University of California, Davis; Department of Veterans Affairs (A.A.K., N.C.), Northern California Health Care System, Mather; Department of Cardiothoracic Surgery (J.N.Y.), University of California, Davis; Jiangsu Key Lab for Bioresource Technology (L.L.), College of Life Science, Nanjing Normal University, China; Center for Calcium and Learning, Division of Life Sciences (H.-S.S.)... Department of Cardiology, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China. College of Food Science and Engineering, Northwest A&F University, Yangling, 712100, China Department of General Surgery, the First Affiliated Hospital with Nanjing Medical University, Nanjing, Jiangsu, PR China School of New Energy and Materials, Southwest Petroleum University (SWPU), Chengdu 610500, P. R. China 1AbbVie, Oncology Discovery, North Chicago, Illinois. Department of Physiology The University of Arizona Tucson AZ; State Key Laboratory of Respiratory Disease The First Affiliated Hospital of Guangzhou Medical University Guangzhou China Department of Infection medicine, the Guanggu District of Hubei Province Maternal and Child Health Hospital, Wuhan, Hubei, China; Department of Biotherapy, the Eastern Hepatobiliary Surgery Hospital, Navy Medical University (Second Military Medical University), Shanghai, China National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, Beijing 100050, China. Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Ningxia Medical University, Yinchuan, China. Department of Urology, National Urological Cancer Center, Peking University First Hospital and Institute of Urology, Peking University, Beijing China. Key Laboratory of Functional Molecule Synthesis of Jilin Province Department of Chemistry Northeast Normal University 5268 Renmin Street Changchun Jilin 130024 P. R. China; State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic Chemistry Chinese Academy of Sciences 345 Lingling Road Shanghai 200032 P. R. China Department of Laboratory Medicine, Zhongnan Hospital of Wuhan University, No. 169 Donghu Road, Wuchang District, Wuhan 430071, P.R. China Department of Cardiology, Xuzhou Central Hospital, Xuzhou, People’s Republic of China Key Laboratory of Industrial Ecology and Environmental Engineering Ministry of Education School of Environmental Science and Technology Dalian University of Technology Dalian China Beijing Laboratory of Biomedical Materials and Beijing Advanced Innovation Center for Soft Matter Science and Engineering; Beijing University of Chemical Technology; Beijing 100029; China National Engineering Research Centre for Biomaterials; Sichuan University; Chengdu 610064; China Marine College; Shandong University; Weihai; People's Republic of China School of Life and Environmental Science, Guilin University of Electronic Technology, Guilin, Guangxi 541000, China State Key Laboratory of Complex Nonferrous Metal Resources Clean Utilization, Faculty of Land Resource Engineering, Kunming University of Science and Technology, Kunming 650093, China; Yunnan Key Laboratory of Green Separation and Enrichment of Strategic Mineral Resources, Kunming University of Science and Technology, Kunming 650093, China Graduate School of Tianjin Medical University Tianjin China; Department of Clinical Laboratory Tianjin Union Medical Center Tianjin China Department of Gastroenterology, China-Japan Union Hospital, Jilin University, Changchun, Jilin Province, China Department of Endocrinology, Key Laboratory of Endocrinology of National Ministry of Health, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College , Beijing, 100730 , China Department of Endocrinology, Chinese PLA General Hospital, Beijing, China; Department of Endocrinology, General Hospital of Beijing PLA Military Command, Beijing, China Department of Dermatology; Peking University Third Hospital; Beijing China Microbiology Laboratory, Central Laboratory, Peking University School and Hospital of Stomatology, Beijing, China. The Center for New Drug Safety Evaluation and Research, Inner Mongolia Medical University, Hohhot, China; The Center for New Drug Screening Engineering and Research of Inner Mongolia Autonomous Region, Inner Mongolia Medical University, Hohhot, China; College of Pharmacy, Inner Mongolia Medical University, Hohhot, China Department of Jiont Orthopaedic Surgery, The Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, China (mainland) State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China; University of Chinese Academy of Sciences, Beijing, China Qingshan District Center for Disease Control and Prevention, Wuhan, 430080, Hubei, China Cancer Hospital, Chinese Academy of Medical Sciences (CAMS) & Peking Union Medical College (PUMC) Beijing People's Republic of China Department of Diagnostic Radiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China School of Civil Engineering and Architecture, Wuhan University of Technology, Wuhan, People’s Republic of China Institute of Nano Biomedicine and Engineering, Shanghai Engineering Research Centre for Intelligent Diagnosis and Treatment Instrument, Department of Instrument Science and Engineering, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, Shanghai, P. R. China; National Center for Translational Medicine, Collaborative Innovational Center for System Biology, Shanghai Jiao Tong University, Shanghai, P. R. China School of Materials and Chemical Engineering; Hubei University of Technology; Wuhan 430068; China Department Chemistry & Biochemistry, Florida State University, 95 Chieftain Way, Tallahassee, Florida 32306, United States Qindao Special servicemen Recuperation Center of PLA Navy, Qingdao, China Graduate College, Guangxi University of Chinese Medicine, Nanning, Guangxi Province, People's Republic of China; Department of Orthopedics, Guilin Municipal Hospital of Traditional Chinese Medicine, Guilin, Guangxi Province, People's Republic of China. From the Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA; and the Department of Molecular Biology, University of Copenhagen, Copenhagen, Denmark. Department of Thoracic Surgery, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health , Beijing, China; Department of Thoracic Surgery, National Clinical Research Center for Respiratory Disease, Ministry of Science and Technology , Beijing, China; Department of Paediatric Surgery, Key Laboratory of Major Diseases in Children, Ministry of Education , Beijing, China; Department of Thoracic Surgery, Beijing Engineering Research Center of Paediatric Surgery , Beijing, China University of Leeds Leeds UK Graduate Institute of Environmental Engineering, National Taiwan University, Taipei, Taiwan, China grid.216938.7 0000000098787032 State Key Program of Microbiology and Department of Microbiology, College of Life Sciences Nankai University Tianjin China School of Chemistry and Chemical Engineering, Chongqing University, Chongqing, China State Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing, China College of Veterinary Medicine, Gansu Agricultural University, Lan Zhou, Gansu Province, China. Jiangsu Key Laboratory of Advanced Laser Materials and Devices, School of Physics and Electronic Engineering, Jiangsu Normal University, Xuzhou 221116, Jiangsu, China School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, People’s Republic of China Department of Emergency, Guizhou Provincial People’s Hospital Department of General Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, PR China College of Chemical Engineering, Nanjing University of Science and Technology, Nanjing 210094, China College of Chemistry and Chemical Engineering, Hubei Polytechnic University, Huangshi, Hubei 435003, P.R. China Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China; University of the Chinese Academy of Sciences, Shanghai, China Department of Endocrinology, Qilu Hospital of Shandong University, Jinan, Shandong 250012, China National Clinical Research Center for Digestive Diseases, Beijing, China; Clinical Epidemiology and EBM Center, Beijing Friendship Hospital, Capital Medical University, Beijing, China Department of Endocrinology, Chinese PLA General Hospital, Beijing 100853, China; Department of Endocrinology, PLA Army General Hospital, Beijing 100700, China Department of Chemistry, Northeast Normal University, Changchun, 130024, P. R. China State Key Laboratory of Fluid Power and Mechatronic Systems, Zhejiang University, Hangzhou, Zhejiang 310027, People’s Republic of China School of Chemistry and Materials Science, Jiangsu Normal University, Xuzhou 221116, People’s Republic of China Faculty of Chemistry; Northeast Normal University; Changchun, P. R. China Chinese Center for Disease Control and Prevention, NHC Key Laboratory of Trace Element Nutrition, National Institute for Nutrition and Health, Beijing 100050, China Division of Advanced Manufacturing, Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, China 1National Health Commission Key Laboratory of Antibody Techniques, Department of Cell Biology, Jiangsu Provincial Key Laboratory of Human Functional Genomics, School of Basic Medical Sciences, Nanjing Medical University, Nanjing, Jiangsu, China.; 2Institute for Brain Tumors, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Personalized Cancer Medicine, Nanjing Medical University, Nanjing, Jiangsu, China. State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100049, China Key Laboratory of Optic-electric Sensing and Analytical Chemistry for Life Science, MOE; Shandong Key Laboratory of Biochemical Analysis; Key Laboratory of Analytical Chemistry for Life Science in Universities of Shandong; College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, P. R. China School of Chemical Engineering and Technology; Tianjin University; Tianjin 300072; China Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104 Department of Laboratory Medicine Fujian Medical University Fuzhou China Department of Pharmacy, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China. State Key Laboratory and Institute of Elemento-Organic Chemistry; Collaborative Innovation Center of Chemical Science and Engineering (Tianjin); School of Materials Science and Engineering; Nankai University; Tianjin 300071 Department of Respiratory Medicine, Affiliated Changzhou No. 2 People's Hospital, Nanjing Medical University, Changzhou, China Medical College of Guizhou University, Guiyang City, China.; State Key Laboratory of Proteomics, National Center for Protein Sciences, Beijing Institute of Radiation Medicine, Beijing, China. Department of Respiratory Medicine, The Affiliated Nanjing Brain Hospital of Nanjing Medical University, Nanjing, China Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China Department of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital, Diabetes Research Center of Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China Department of Pharmacy Shanghai Public Health Clinical Center Fudan University Shanghai China Key Laboratory of Endocrinology Ministry of Health Department of Endocrinology Peking Union Medical College Hospital Diabetes Research Center of Chinese Academy of Medical Science & Peking Union Medical College Beijing China College of Materials and Chemistry & Chemical Engineering; Chengdu University of Technology; Chengdu 610059; China Department of Neurosurgery, the Fifth Medical Centre, Chinese PLA General Hospital, Beijing, China Department of Gastroenterology Beijing Friendship Hospital Capital Medical University National Clinical Research Center for Digestive Diseases Beijing Digestive Disease Center Beijing Key Laboratory for Precancerous Lesion of Digestive Diseases Beijing 100050 China Department of Traditional Chinese Medicine, Huai'an Second People's Hospital, The Affiliated Huai'an Hospital of Xuzhou Medical University, Huai'an, Jiangsu 223001, P.R. China Institute of Functional Nano & Soft Materials (FUNSOM) and Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University, Suzhou, Jiangsu 215123, China Department of Respiratory Medicine, East Hospital Tongji University School of Medicine Shanghai China The Center for Drug Safety Evaluation and Research Shanghai Institute of Materia Medica Chinese Academy of Sciences (CDSER/SIMM) Shanghai City China Department of Oncology, Xiamen Fifth Hospital, Fujian Xiamen, China Tianjin Key Laboratory of Organic Solar Cells and Photochemical Conversion, School of Chemistry and Chemical Engineering, Tianjin University of Technology, Tianjin 300384, People’s Republic of China Institute of Nano Biomedicine and Engineering; Shanghai Engineering Research Centre for Intelligent Diagnosis and Treatment Instrument; Department of Instrument Science and Engineering; School of Electronic Information and Electrical Engineering; Shanghai Jiao Tong University Department of Forest Resources and Environmental Conservation Virginia Tech Blacksburg Virginia USA Department of Respiratory Medicine, The First Affiliated Hospital, Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, China. Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, 1219 Zhongguan West Rd., Zhenhai District, Ningbo, Zhejiang Province 315201, P. R. China Key Laboratory of Animal Physiology, Biochemistry and Molecular Biology of Hebei Province, College of Life Sciences, Hebei Normal University, Shijiazhuang, Hebei, China Department of Periodontology, General Hospital of Ningxia Medical University, Yinchuan, Ningxia 750004, P.R. China Department of Radiotherapy, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, The Affiliated Cancer Hospital of Nanjing Medical University, Nanjing 210009, Jiangsu, China Key Laboratory of Functional Polymer Materials of Ministry of Education, and Institute of Polymer Chemistry, Nankai University, and Collaborative Innovation Center of Chemical Science and Engineering, Tianjin 300071, China College of Physics and Materials Science; Henan Normal University; Xinxiang; People's Republic of China Key Laboratory of Sweet Potato Biology and Biotechnology Ministry of Agriculture and Rural Affairs/Beijing Key Laboratory of Crop Genetic Improvement/Laboratory of Crop Heterosis & Utilization and Joint Laboratory for International Cooperation in Crop Molecular Breeding Ministry of Education College of Agronomy & Biotechnology China Agricultural University Beijing 100193 China School of Preclinical Medicine, Beijing University of Chinese Medicine, Beijing 100029, P.R. China 3Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania. Department of Pathology, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu, China (mainland) State Key Laboratory of Fluid Power and Mechatronic Systems, Zhejiang University, Hangzhou, Zhejiang 310027, China State Key Laboratory of Fluid Power and Mechatronic Systems, Zhejiang University, Hangzhou, Zhejiang 310027, P. R. China Laboratory of Drosophila Research, School of Life Sciences, Faculty of Science, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong SAR, China; Biochemistry Program, School of Life Sciences, Faculty of Science, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong SAR, China Center for Reproductive Medicine Cheeloo College of Medicine Shandong University Jinan China; National Research Center for Assisted Reproductive Technology and Reproductive Genetics Shandong University Jinan China Department of Medical Oncology, Affiliated Hospital of Hebei University, Hebei Key Laboratory of Cancer Radiotherapy and Chemotherapy, Baoding, China. National Technology Center; Guangxi Bossco Environmental Protection Technology Co Ltd; Nanning 530004; China Department of Urology, Institute of Urology, The First Hospital, Peking University, Beijing, 100034, PR China. Marine College, Shandong University (Weihai), Weihai, PR China; Department of Gynecology and Obstetrics, Tongzhou Maternal and Child Health Hospital of Beijing, Beijing 101101, China Department of Health Management, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China; The Key Laboratory for Human Disease Gene Study of Sichuan Province and Institute of Laboratory Medicine, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical Technology Beijing 100029 China Department of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan, PR China MOE Key Laboratory for Standardization of Chinese Medicines, SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Institute of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine Shanghai 201203, China Shanghai R&D Center for Standardization of Chinese Medicines Shanghai 201203, China. Key Laboratory of Functional Polymer Materials and the Center for Nanoscale Science and Technology, Institute of Polymer Chemistry, College of Chemistry, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Nankai University, Tianjin 300071, China Department of Cardiovascular Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China; Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Xuzhou Medical University, Xuzhou, China Laboratory of Animal Anatomy & Tissue Embryology, Department of Basic Veterinary Medicine College of Veterinary Medicine, Gansu Agricultural University Lanzhou Gansu China Department of Urology School of Life Sciences, Beijing University of Chinese Medicine, Beijing 100029, China State Key Laboratory of Mechanics and Control of Mechanical Structures, Nanjing University of Aeronautics and Astronautics, Nanjing 210016, China Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation School of Pharmacy Huazhong University of Science and Technology 13 Hangkong Road, Wuhan Hubei 430030 China Key Laboratory of Electronics Engineering, College of Heilongjiang Province Heilongjiang Univ. Harbin 150080 China Key Laboratory of Digital Quality Evaluation of Chinese MateriaMedica of State Administration of TCM; P. R. China Institut für Mikrobiologie, Technische Universität Dresden, Dresden, Germany Department of Orthopaedic Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA University of Leeds, Leeds, UK; and Key Laboratory of Optic-electric Sensing and Analytical Chemistry for Life Science; MOE; Shandong Key Laboratory of Biochemical Analysis; Key Laboratory of Analytical Chemistry for Life Science in Universities of Shandong; College of Chemistry and Molecular Engineering Department of Civil and Environmental Engineering, University of Hawaii at Manoa, Honolulu, Hawaii, USA School of Materials Science and Engineering, Tianjin University, Tianjin 300072, P. R. China Collaborative Innovation Center for the Origin and Control of Emerging Infectious Diseases, Shandong First Medical University (Shandong Academy of Medical Sciences), Taian, China; School of Basic Medical Science, Shandong First Medical University (Shandong Academy of Medical Sciences), Taian, China Center for Translational Cancer Research; Institute of Biosciences and Technology; College of Medicine; Texas A&M University; Houston †National Key Laboratory of Medical Molecular Biology and Department of Immunology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing 100005, China; and College of Veterinary Medicine Gansu University of Agriculture Lanzhou 730070 Gansu China; Department of Hematology Lanzhou General Hospital, Lanzhou Command Lanzhou Gansu China Key Laboratory of Functional Organic Molecule Design & Synthesis of Jilin Province, Department of Chemistry, Northeast Normal University, 5268 Renmin Street, Changchun, Jilin 130024, China Hubei Key Laboratory of Genetic Regulation and Integrative Biology, School of Life Sciences, Central China Normal University, China School of Nursing, Lanzhou University Lanzhou 730000, China. Department of Pharmacology and Chemical Biology, State Key Laboratory of Oncogenes and Related Genes, Shanghai Universities Collaborative Innovation Center for Translational Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, People’s Republic of China School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China (mainland) Heilongjiang University of Chinese Medicine, China; The First Affiliated Hospital of Heilongjiang University of Chinese Medicine, China. College of Food Science and Engneering, Jilin University, Changchun, People’s Republic of China Department of Clinical Pharmacology The Second Affiliated Hospital of Anhui Medical University Hefei China Diseases Center, Department of Hepatopancreatobiliary Medicine, The Second Hospital, Jilin University, Changchun, China Department of Statistics University of Chicago Chicago Illinois Department of Anesthesiology, Tianjin Central Hospital of Gynecology Obstetrics, Gynecology Obstetrics Hospital of Nankai University, Tianjin Key Laboratory of Human Development and Reproductive Regulation, Tianjin 300052, China Department of Emergency, Guizhou Provincial People’s Hospital, Guiyang 550004, PR. China Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing 210009, China. Key Laboratory of Agricultural Microbiology, College of Agriculture, Guizhou University, Guiyang 550025, China State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, China; Institute of Plant Biology, School of Life Sciences, Fudan University, Shanghai, China Key Laboratory of the Ministry of Education for Medicinal Resources and Natural Pharmaceutical Chemistry National Engineering Laboratory for Resource Development of Endangered Chinese Crude Drugs in Northwest China College of Life Sciences Shaanxi Normal University Xi'an China Institute of Environmental and Chemical Engineering Dalian University Dalian China Endoscopic Center of Nanjing Chest Hospital, Nanjing, Jiangsu, China; Clinical Center of Nanjing Respiratory Diseases and Imaging, Nanjing, Jiangsu, China Department of Nutrition and Food Hygiene School of Public Health China Medical University Shenyang P.R. China From the Division of Cardiovascular Medicine (Q.Z., V.T., L.L., N.L., A.S., M.K.L., N.C.), Department of Internal Medicine, University of California, Davis, Calif; Department of Veterans Affairs (N.C.), Northern California Health Care System, Mather, Calif; Vollum Institute (C.T.B., J.P.A.), Oregon Health and Science University, Portland; and Department of Physiology (Q.Z.), University of Zhengzhou, Henan, People’s Republic of China. Department of Nuclear Medicine, Tongji University School of Medicine, Shanghai Tenth People’s Hospital, Shanghai, China National University of Defense Technology CAS Key Laboratory of Marine Ecology and Environmental Sciences, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China. College of Earth Sciences, University of Chinese Academy of Sciences, Beijing 100049, China. College of Chemistry Liaoning University Shenyang 110036 P.R. China Key Laboratory for Functional Polymer Materials and Centre for Nanoscale Science and Technology, Institute of Polymer Chemistry, College of Chemistry, Nankai University, Tianjin 300071, China Department of Pathology Binzhou Medical University Binzhou China Zibo Disease Control and Prevention Center, Zibo, China. School of Chemistry and Chemical Engineering Chongqing University Chongqing P. R. China Department of Allergy, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College Beijing 100730, China. Beijing Key Laboratory of Precision Medicine for Diagnosis and Treatment on Allergic Diseases Beijing 100730, China. National Clinical Research Center for Dermatologic and Immunologic Diseases Beijing 100034, China. School of Nursing, Lanzhou University, Lanzhou Tianjin Key Laboratory of Low Dimensional Materials Physics and Preparation Technology; Faculty of Science; Tianjin University; Tianjin 300354; China Department of Radiotherapy, Zhongshan Hospital, Fudan University, Xuhui, Shanghai 200032, P.R. China NHC Key Laboratory of Trace Element Nutrition, National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, Beijing 100050, China. Division of Nephrology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People’s Republic of China Department of Infectious Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China School of Automation Science and Electrical Engineering, Beihang University, Beijing 100191, China 1Genelux Corporation, San Diego Science Center, San Diego, California; Department of Urology Peking University First Hospital Institute of Urology Peking University National Urological Cancer Center State Key Laboratory of Explosion Science and Technology, Beijing Institute of Technology, Beijing, China; College of Food Science and Engineering, Ocean University of China, Sansha Road, Qingdao 266404, China Key Laboratory of Green Processing and Functional New Textile Materials of Ministry of Education, Wuhan Textile University, Wuhan 430200, China; Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials, Key Laboratory for the Green Preparation and Application of Functional Materials, Ministry of Education, Hubei Key Laboratory of Polymer Materials, School of Materials Science and Engineering, Hubei University, Wuhan 430062, P. R. China Department of Botany University of British Columbia Vancouver BC V6T 1Z4 Canada Laboratory of Animal Anatomy & Tissue Embryology, Veterinary Medicine of college, Gansu Agricultural University, Lanzhou, PR China Department of Pediatrics Peking University First Hospital Beijing China State Key Laboratory and Institute of Elemento-Organic Chemistry and Centre for Nanoscale Science and Technology; Institute of Polymer Chemistry; College of Chemistry; Collaborative Innovation Center of Chemical Science and Engineering (Tianjin); College of Chemistry Research and Development, Bristol Myers Squibb, 700 Bay Road, Redwood City, California 94063, United States Chinese Centers for Disease Control and Prevention, Beijing 100050 Department of Chemistry, Xi’an Jiaotong-Liverpool University, Suzhou, Jiangsu, China College of Resources and Environment Engineering, Shandong University of Technology, Zibo 255000, China Key Laboratory of Tumor Molecular Biology in Binzhou Medical University, Department of Biochemistry and Molecular Biology, Binzhou Medical University, YanTai, Shandong 264003, P.R. China Department of Experimental Genome Research, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan; Laboratory Animal Center, Chongqing Medical University, Chongqing, China Key Laboratory of Acupuncture and Tuina for Treatment of Encephalopathy, College of Acupuncture, Tuina and Rehabilitation, Yunnan University of Traditional Chinese Medicine, Kunming 650500, China Department of Oral and Maxillofacial Surgery; Nanjing Stomatology Hospital; Medical School of Nanjing University; Nanjing; China From the Departments of Pharmacology, Physiology, and the Vascular Biology Center, Medical College of Georgia, Augusta. Department of Emergency and Critical Care Medicine, Pudong New Area People’s Hospital Affiliated to Shanghai University of Medicine and Health Sciences, Shanghai, China (mainland) Key Laboratory of Ocean Energy Utilization and Energy Conservation of Ministry of Education; Dalian University of Technology; Dalian 116024; China Department of Ornamental Horticulture China Agricultural University Beijing 100193 China School of Mechanical Engineering, Shenyang Jianzhu University, Shenyang 110168, China State Key Laboratory of Tree Genetics and Breeding, Key Laboratory of Tree Breeding and Cultivation of the State Forestry Administration, Research Institute of Forestry Chinese Academy of Forestry Beijing 100091 China School of Chemistry and Chemical Engineering, Chongqing University, Chongqing 401331, China. Department of Cardiac Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Sciences, Nankai University; Tianjin; China Department of Emergency, State Key Laboratory of Biotherapy, West China Hospital, and School of Chemical Engineering, Sichuan University, No. 17 Renmin Nan Road, Chengdu, 610041, China College of Mechanical and Electrical Engineering, Gansu Agricultural University, Lanzhou 730070, China Department of Nephrology, Hebei Province of Chinese Medicine, Shijiazhuang City, Hebei Province, China Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, China; Department of Chemistry, Key Laboratory of Functional Molecule Design and Synthesis of Jilin Province, Northeast Normal University, Changchun, 130024, P. R. China Department of Stomatology, Rizhao Central Hospital, Shandong Province, PR China National Laboratory of Mineral Materials, School of Materials Science and Technology, China University of Geosciences, Beijing, 100083, China College of Land Science and Technology China Agriculture University Beijing 100193 China; Institute of Geographic Sciences and Natural Resources Research Chinese Academy of Sciences Beijing 100101 China Department of General Surgery, the First Affliated Hospital with Nanjing Medical University, Nanjing, Jiangsu, PR China Authors' Affiliations: 1Department of Gynecologic Oncology and Reproductive Medicine and 2Department of Pathology, The University of Texas MD Anderson Cancer Center; 3Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston Medical School; and 4Department of Diagnostic and Biomedical Sciences, The University of Texas School of Dentistry at Houston, Houston, Texas Horizon Robotics, Beijing, China Department of Chemistry Jilin Province Key Laboratory of Organic Functional Molecular Design & Synthesis Northeast Normal University Changchun 130024 China; State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic Chemistry Chinese Academy of Sciences 345 Lingling Lu Shanghai 200032 China Key Laboratory of Resource Biology and Biotechnology in Western China Ministry of Education/College of Life Science Northwest University Xi'an 710069 P. R. China; District Traditional Chinese Medicine Hospital of Xi'an Shaanxi Province Xi'an 710100 P. R. China College of Science Nanjing Forestry University Nanjing 210037 China The Centre of Nanoscale Science and Technology and Key Laboratory of Functional Polymer Materials; State Key Laboratory and Institute of Elemento-Organic Chemistry; Collaborative Innovation Center of Chemical Science and Engineering (Tianjin); College of Chemistry; Nankai University Department of Chemistry, College of Chemistry and Chemical Engineering, The MOE Key Laboratory of Spectrochemical Analysis and Instrumentation, and iChEM, Xiamen University, Xiamen 361005, China Department of Educational Psychology and Learning Systems, Florida State University Beijing Key Laboratory of Materials Utilization of Nonmetallic Minerals and Solid Wastes; National Laboratory of Mineral Materials; School of Materials Science and Technology; China University of Geosciences; Beijing, China Center for Reproductive Medicine, Shandong University, Jinan, China; Key Laboratory of Reproductive Endocrinology of Ministry of Education, Shandong University, Jinan, China; Shandong Key Laboratory of Reproductive Medicine, Jinan, China; Shandong Provincial Clinical Research Center for Reproductive Health, Jinan, China; Shandong Technology Innovation Center for Reproductive Health, Jinan, China Department of Respiratory Medicine, Changzhou No.2 People's Hospital Affiliated to Nanjing Medical University, Changzhou 213003, China Department of Oral and Maxillofacial Surgery, Nanjing Stomatology Hospital, Medical School of Nanjing University, Nanjing, China Department of Epidemiology, Cancer Institute/Hospital, Chinese Academy of Medical Sciences and Peking Union of Medical College, Beijing, People's Republic of China; College of Life Sciences, Sichuan University, Chengdu 610065, China Department of Hematology, Xuzhou Medical College Affiliated Hospital, Jiangsu Province, China. State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University , Fujian 361102 , China Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. E-mail: chenyuezhang@163.com. Department of Oral and Maxillofacial Surgery Nanjing Stomatological Hospital Medical School of Nanjing University Nanjing China Department of Chemistry, Northeast Normal University, Changchun 130024, P. R. China dongdw663@nenu.edu.cn Department of Cardiovascular Surgery, Shandong Provincial Hospital Affiliated to Shandong University Sino-France Laboratory for Drug Screening, Key Laboratory of Molecular Biophysics of Ministry of Education, School of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, P. R. China Department of Radiation Oncology, The Affiliated Cancer Hospital of Nanjing Medical University & Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research, Nanjing, China College of Materials and Mineral Resources, Xi’an University of Architecture and Technology, Xi’an 710055, China CAS Key Laboratory of High-Performance Synthetic Rubber and its Composite Materials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China School of Chemical Engineering, Chongqing University of Technology, Chongqing 400054, China. Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, Beijing Key Laboratory for Precancerous Lesion of Digestive Disease, National Clinical Research Center for Digestive Diseases, Beijing 100050, China State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing, 210009, P.R. China Department of Acupuncture, Second Affiliated Hospital Heilongjiang University of Chinese Medicine Harbin PR China Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China; China National Clinical Research Center for Neurological Diseases, Beijing, China Department of Respiratory and Critical Medicine Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China Department of Chemistry, Institute for Polymer Research, Waterloo Institute for Nanotechnology, University of Waterloo, Waterloo, Ontario N2L 3G1, Canada Department of Materials Science and Engineering, Jinan University, Guangzhou 510632, P. R. China The Center of New Energy Materials and Technology, School of New Energy and Materials, Southwest Petroleum University, Chengdu 610500, China State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China 1; Graduate University of Chinese Academy of Sciences, Beijing, China 3 Department of Pharmacy, Xinqiao Hospital, Army Medical University, Chongqing 400037, P.R.�China Department of Hematology, Lanzhou General Hospital, Lanzhou Military Area, Lanzhou, Gansu Province, China. School of Information Engineering, Tianjin University of Commerce, Tianjin 300134, China Department of Biomedical Sciences, Creighton University School of Medicine, Omaha, Nebraska China International Science and Technology Cooperation Base of Food Nutrition/Safety and Medicinal Chemistry; State Key Laboratory of Food Nutrition and Safety; Tianjin University of Science and Technology; Tianjin 300457; China Department of Infectious Diseases, Institute for Viral Hepatitis, The Key Laboratory of Molecular Biology for Infectious Diseases, Chinese Ministry of Education, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China; Department of Infectious Diseases, Guizhou Provincial People's Hospital, Guiyang, Guizhou 550001, China. Department of Biochemistry and Molecular Biology, Tulane University Health Science Center, New Orleans, LA 70112 Xi’An University of Posts & Telecommunications College of Pharmacy Fujian Medical University Fuzhou 350108 P. R. China State Key Laboratory of Optoelectronic Materials and Technologies School of Materials Sun Yat-Sen University Guangzhou 510275 China Ministry of Education Key Laboratory of Child Development and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing Key Laboratory of Translational Medical Research in Cognitive Development and Learning and Memory Disorders, Children Nutrition Research Center, Children’s Hospital of Chongqing Medical University, Chongqing Key Laboratory of Child Nutrition and Health, Chongqing, People’s Republic of China Key Laboratory of Northwest Resource, Environment and Ecology, MOE, Xi’an University of Architecture and Technology, Xi’an 710055, China School of Ecology and Environmental Sciences Tiantong National Station of Forest Ecosystem East China Normal University Shanghai 200241 China Department of Gastroenterology, The Affiliated Hospital of Qingdao University, Qingdao,PR China Laboratory for the Modeling of Biological and Socio-technical Systems, Northeastern University, Boston, MA 02115; Institute of Geographic Sciences and Natural Resources Research, Chinese Academy of Sciences, Beijing, China Department of Applied Chemistry; Xi'an University of Technology; Xi'an; China; State Key Laboratory of Eco-hydraulics in Northwest Arid Region Department of Respiratory Medicine The Affiliated Brain Hospital of Nanjing Medical University Nanjing China; Clinical Center of Nanjing Respiratory Diseases and Imaging Nanjing China From the Institute of Medical Microbiology and Immunology, University of Copenhagen, Copenhagen, Denmark; Institute of Human Genetics, University of Aarhus, Aarhus, Denmark; Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, PA; and Signal Transduction, Novo Nordisk Discovery, Bagsværd, Denmark. From the Departments of Radiology (B.S., M.A.v.B.) and Gerontology and Geriatrics (B.S., A.J.M.d.C.), Leiden University Medical Center, the Netherlands; Icelandic Heart Association (S.S., V.G.), Reykjavik, Iceland; Intramural Research Program (Q.Z., T.B.H., L.J.L.), National Institute on Aging, NIH, Bethesda, MD; Faculty of Medicine (V.G.), University of Iceland, Reykjavik; and Cardiovascular and Pulmonary Branch (A.E.A.), National Heart, Lung, and Blood Institute, NIH, Bethesda, MD. Department of Systems Biology for Medicine of School of Basic Medical Sciences, and Institutes of Biomedical Sciences, Fudan University, Shanghai, China Jilin Province Key Laboratory of Organic Functional Molecular Design & Synthesis; Department of Chemistry; Northeast Normal University; Changchun; China Key Laboratory of Industrial Ecology and Environmental Engineering (Ministry of Education); School of Ocean Science and Technology; Dalian University of Technology; Panjin 124221; China Key Laboratory of Zoonosis; Ministry of Education; Institute of Zoonosis; College of Animal Science and Veterinary Medicine; Jilin University; Changchun; China School of Materials Science and Engineering, University of Science and Technology Beijing, Beijing 100083, China Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), NMPA Key Laboratory for Research and Evaluation of Radiopharmaceuticals, Department of Nuclear Medicine, Peking University Cancer Hospital & Institute, Beijing 100142, China Department of Pharmacology and Chemical Biology, State Key Laboratory of Oncogenes and Related Genes, Shanghai Universities Collaborative Innovation Center for Translational Medicine, Shanghai Jiao Tong University School of Medicine, 280 South Chongqing Road, Shanghai 200025, China Key Laboratory of Plant Gene Resources and Biotechnology for Carbon Reduction and Environmental Improvement, Beijing Municipal Government, and College of Life Sciences,College of Life Sciences, Capital Normal University, Beijing 100048, China Department of Pediatric Intensive Care Unit, National Center for Cardiovascular Disease and Fuwai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA College of Resources and Environmental, Henan Agricultural University, Zhengzhou, P R China; Department of Pathology and Laboratory Medicine and Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan, Hubei 430030, People’s Republic of China State Key Laboratory of Fluorine & Nitrogen Chemicals, Xi’an Modern Chemistry Research Institute, Xi’an 710065, P. R. China Science and Technology Department, Anhui University of CM, Hefei 230038, China. Department of Acupuncture and Moxibustion, Heilongjiang University of Chinese Medicine Second Affiliated Hospital, Harbin 150000, Heilongjiang, China Institute of Physical Chemistry, RWTH Aachen University, Landoltweg, 252074 Aachen, Germany; Forschungszentrum Jülich GmbH, Institute for Energy and Climate Research: Fundamental Electrochemistry (IEK-9), Wilhelm-Johnen-Straße, D-52425 Jülich, Germany Department MOE Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology Department of Chemistry Tsinghua University Beijing 100084 China School of Pharmacy Southwest Medical University Luzhou China School of Civil Engineering and Architecture, Wuhan University of Technology, Wuhan 430070, China Department of Medicine University of California San Diego, La Jolla California; Department of Physiology The University of Arizona Tucson Arizona; State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Disease The First Affiliated Hospital of Guangzhou Medical University Guangzhou China Department of Chemistry, Florida State University, Tallahassee, Florida 32306, United States Clinical Trials Center The Affiliated Hospital of Guizhou Medical University Guiyang China Marine College, Shandong University, Weihai, Shandong, 264209, China Department of Gastrointestinal Medical Oncology (QZ, JL, JLA, LH), University of Texas M. D. Anderson Cancer Center, Houston, Texas Affiliated Hospital of Qingdao University and Biomedical Sciences Institute of Qingdao University (Qingdao Branch of SJTU Bio-X Institutes), Qingdao University, Qingdao, China Laboratory Medicine Center, Lanzhou University Second Hospital, Lanzhou 730030, PR China *Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104; School of Chemical Engineering and Materials, Changzhou Institute of Technology, No. 666 Liaohe Road, Changzhou 213032, China Department of Pharmacology and Chemical Biology Shanghai Jiao Tong University School of Medicine 280 South Chongqing Road Shanghai 200025 P. R. China Department of Food Quality and Safety, College of Food Science and Engineering, Jilin University, Changchun 130062, China Department of Pharmacy Institute of Surgery Research Daping Hospital Third Military Medical University Chongqing China Department of Respiratory and Critical Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China Key Laboratory of Endocrinology, Translational Medicine Centre, Ministry of Health, Department of Endocrinology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, P.R. China Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan China Department of Gastrointestinal Surgery, Beijing Tsinghua Changgung Hospital, Beijing 102218, China Clinical Epidemiology and EBM Unit, Beijing Friendship Hospital, Capital Medical University School of Medicine Guizhou University Guiyang China; Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Key Laboratory for Research and Evaluation of Radiopharmaceuticals (National Medical Products Administration), Department of Nuclear Medicine Peking University Cancer Hospital & Institute Beijing China School of Pharmacy, Key Laboratory of Sichuan Province for Specific Structure of Small Molecule Drugs, Chengdu Medical College, Chengdu 610500, China Department of Radiotherapy, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research The Affiliated Cancer Hospital of Nanjing Medical University Nanjing P.R. China National Clinical Research Center for Digestive Diseases Beijing China; Clinical Epidemiology and Evidence‐Based Medicine Unit Beijing Friendship Hospital, Capital Medical University Beijing China St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY 1 Center for Reproductive Medicine, Shandong University , Jinan, China; Key Laboratory of Reproductive Endocrinology of Ministry of Education, Shandong University , Jinan, China; Shandong Key Laboratory of Reproductive Medicine , Jinan, China; Shandong Provincial Clinical Research Center for Reproductive Health , Jinan, China; Shandong Technology Innovation Center for Reproductive Health , Jinan, China; National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University , Jinan, China Department of Stomatology, The Second Xiangya Hospital, Central South University, Changsha 410011, China Department of Materials Science and Engineering, Northwestern University, 2220 Campus Drive, Evanston, Illinois 60208, United States St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, New York, USA. Department of Soil and Water and Climate, University of Minnesota Key Laboratory of Industrial Ecology and Environmental Engineering (Ministry of Education), School of Ocean Science and Technology, Dalian University of Technology, Panjin 124221, China School of Pharmacy,Nanjing University of Chinese Medicine Nanjing 210023,China. Department of Applied Chemistry, Hefei Science Center of Chinese Academy of Sciences, University of Science and Technology of China, Hefei, Anhui 230026, China Nanjing Stomatological Hospital; Medical School of Nanjing University; Nanjing; P. R. China Institute of Soil and Water Resources and Environmental Science, Zhejiang Provincial Key Laboratory of Subtropical Soil and Plant Nutrition, Zhejiang University, Hangzhou 310058, China Beijing University of Chinese Medicine, Bei San Huan Dong Lu 11, Chao Yang District, Beijing 100029, China Key Laboratory of Fertility Preservation and Maintenance (Ministry of Education) Ningxia Medical University Yinchuan China Qian Zhang, Wen-Qian Qi, Yong-Gui Zhang, Ping Zhao, Jian Jiao, Jiang-Bin Wang, Department of Gastroenterology, China-Japan Union Hospital Affiliated to Jilin University, Changchun 130000, Jilin Province, China. School of Science, Hebei University of Technology, Tianjin 300401, P. R. China New Materials and Green Manufacturing Talent Introduction and Innovation Demonstration Base, School of Materials and Chemical Engineering, Hubei University of Technology, Wuhan 430068, China Department of Applied Chemistry, Xi’an University of Technology, Xi’an, China; Department of Experimental Genome Research, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan, China. College of Pharmacy, Fujian Medical University, Fuzhou, PR China; Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University; China National Clinical Research Center for Neurological Diseases; Center of Stroke, Beijing Institute for Brain Disorders; and Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing; and Department of Otorhinolaryngology‐Head and Neck Surgery, Shandong Provincial ENT Hospital Shandong University Jinan China Department of Pediatrics Peking University First Hospital Beijing China; Children Epilepsy Center Peking University First Hospital Beijing China Department of Urology, Peking University First Hospital, Institute of Urology, Peking University, Urogenital Diseases (Male) Molecular Diagnosis And Treatment Center, National Research Center for Genitourinary Oncology, Beijing, China. Jilin Province Key Laboratory of Functional Organic Molecule Design & Synthesis, Department of Chemistry, Northeast Normal University, Changchun 130024, China; State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, 345 Lingling Lu, Shanghai 200032, China Jiangsu Provincial Key Laboratory of Bionic Functional Materials, College of Mechanical and Electrical Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing 210016, China Department of School Nutrition, Institute of Nutrition and Food Safety, Chinese Centers for Disease Control and Prevention, Beijing 100050, China. Division of Advanced Manufacturing, Graduate School at Shenzhen Tsinghua University Shenzhen 518055 China; State Key Laboratory of Precision Measurement Technology and Instruments, Department of Precision Instrument Tsinghua University Beijing 100084 China Department of Gastroenterology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China Beijing Key Laboratory of Learning and Cognition Capital Normal University Beijing China Institute of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, P.R. China Department of Cardiac Surgery, Provincial Hospital Affiliated to Shandong University, Jinan 250021, Shandong, China. Key Laboratory of Nonferrous Metals Chemistry and Resources Utilization of Gansu Province, State Key Laboratory of Applied Organic Chemistry, and College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou City, Gansu Province, China Shandong Academy of Forestry Sciences, Jinan, Shandong, China Department of Orthopedics, General Hospital of Jincheng Anthracite Mining Group Co., Ltd., Jincheng, China Department of Oral and Maxillofacial Surgery Nanjing Stomatology Hospital, Medical School of Nanjing University Nanjing Jiangsu China Key Laboratory of Northwest Resource, Environment and Ecology, MOE, Xi’an University of Architecture and Technology, Xi’an 710055, China; Department of Environmental Science and Engineering, Xi’an Jiaotong University, Xi’an 710049, China Department of Hepatobiliary Surgery, Guangxi Medical University Cancer Hospital, Nanning, China; Key Laboratory of Early Prevention and Treatment for Regional High-Frequency Tumors, Ministry of Education, Nanning, China School of Pharmacy Hangzhou Medical College Hangzhou China Department of Occupational and Environmental Health, Key Laboratory of Environment and Health, Ministry of Education, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, PR China Beijing University of Posts and Telecommunications School of Chemistry and Chemical Engineering, MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage, Harbin Institute of Technology, Harbin 150001, China State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China; College of Life Sciences, University of Chinese Academy of Sciences, Beijing, China School of Chemistry and Chemical Engineering, Chongqing University, Chongqing 401331, China Department of Neurology, Xuanwu Hospital, Capital Medical University Endoscopic Center of Nanjing Chest Hospital; Clinical Center of Nanjing Respiratory Diseases and Imaging Department of Pharmacy, The Affiliated Suzhou Hospital of Nanjing Medical University, Gusu School, Nanjing Medical University, Suzhou 215008, China Department of Gastroenterology, Beijing Key Laboratory for Precancerous Lesion of Digestive Disease, Beijing Friendship Hospital, Capital Medical University, National Clinical Research Center for Digestive Disease, Beijing Digestive Disease Center , Beijing, China College of Food Science and Technology Henan University of Technology Zhengzhou China Department of Biochemistry and Molecular Biology, Ningxia Medical University, Yinchuan, China School of Aerospace, Northwestern Polytechnical University, Xi’an 710072, China State Key Laboratory of Reproductive Medicine, The Research Center for Bone and Stem Cells, Department of Anatomy, Histology and Embryology Nanjing Medical University Nanjing China State Key Laboratory of Eco-Hydraulics in Northwest Arid Region, Department of Applied Chemistry, Xi’an University of Technology, Xi’an 710048, P.R. China Heart center of Peking University People's Hospital, Beijing 100044, China. Department of Nutrition and Health, China Agricultural University, Beijing 100193, China; Food Laboratory of Zhongyuan, Luohe 462300, China Department of Obstetrics, Qingdao Municipal Hospital, Qingdao 266000, China The First Affiliated Hospital, College of Medicine; Zhejiang University; Hangzhou 310003; P. R. China Breeding Research Lab, Animal Husbandry and Veterinary Research Institute of Qingdao, Qingdao, China Department of Pharmacy, Xinqiao Hospital, Army Medical University, Chongqing, 400037, P.R. China School of Economics and Management, Beijing Forestry University, Beijing 100083, People’s Republic of China Department of Pharmacology, Institute of Medical Sciences, Shanghai Jiao Tong University School of Medicine, 280 South Chongqing Road, Shanghai 200025, People's Republic of China Key Laboratory of Combinatory Biosynthesis and Drug Discovery (Ministry of Education) School of Pharmaceutical Sciences Wuhan University Wuhan 430071 China Genelux Corporation, San Diego Science Center, San Diego, CA 92109, USA Department of Chemistry, Northeast Normal University, Changchun, 130024, P. R. China liuqun@nenu.edu.cn Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital,Beijing University of Chinese Medicine Beijing 100700, China. Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Sciences, Nankai University, Tianjin, China State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100193, People's Republic of China Department of Anesthesiology, Hospital of Stomatology China Medical University Shenyang City China Key Laboratory of Carcinogenesis and Translational Research, NMPA Key Laboratory for Research Evaluation of Radiopharmaceuticals (Ministry of Education/Beijing) Department of Nuclear Medicine Peking University Cancer Hospital and Institute Beijing 100142 China State Key Laboratory of Pathogen and Biosecurity, Institute of Microbiology and Epidemiology, Beijing 100071, China. Intramural Research Program, National Institute on Aging, National Institutes of Health, Bethesda, MD Tianjin Key Laboratory of Organic Solar Cells and Photochemical Conversion; School of Chemistry and Chemical Engineering; Tianjin University of Technology; Tianjin 300384; People's Republic of China State Key Laboratory of Cellular Stress Biology School of Life Sciences Xiamen University Xiamen 361102 China School of Chemistry and Chemical Engineering, Chongqing University, Chongqing, P.R. China; National Laboratory of Solid State Microstructures College of Engineering and Applied Sciences Jiangsu Key Laboratory of Artificial Functional Materials Frontiers Science Center For Critical Earth Material Cycling Nanjing University Nanjing 210093 P. R. China; State Key Laboratory of New Textile Materials and Advanced Processing Technologies Wuhan Textile University Wuhan 430200 P. R. China Department of Dermatology, Huazhong University of Science and Technology Union Shenzhen Hospital, Shenzhen, PR China Department of UrologyNational Research Center for Genitourinary OncologyPeking University First Hospital and Institute of Urology Beijing China

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