http://rdf.ncbi.nlm.nih.gov/pubchem/author/MD5_07d861937bbead55c8b96df00a18b3d3
Outgoing Links
Predicate | Object |
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family-name | Li Jian Li |
name | Jian Li |
given-name | Jian |
organization-name | Institute for Medical Informatics, Biometry and Epidemiology, Ludwig Maximilian University of Munich, Munich, Germany.; German Cancer Consortium (DKTK), Heidelberg, Germany.; German Cancer Research Center (DKFZ), Heidelberg, Germany. Department of Anesthesiology Dushu Lake Hospital Affiliated to Soochow University Suzhou China; Department of Anesthesiology The First Affiliated Hospital of Soochow University Suzhou China Department of Orthopedics, Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu, China. Drug Development and Innovation, Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, Australia State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, Lanzhou 730000, People’s Republic of China Institutes of Biomedical Sciences of Fudan University Key Laboratory of Bio-based Material Science and Technology of Ministry of Education Northeast Forestry University 26 Hexing Road Harbin 150040 P. R. China CAS Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai Chinese Academy of Sciences Shanghai China Department of Gastrointestinal Surgery, Jiangxi Provincial People’s Hospital Affiliated to Nanchang University, Nanchang city, Jiangxi Province, China Key Laboratory of Soft Machines and Smart Devices of Zhejiang Province; Hangzhou; China; Department of Engineering Mechanics; Zhejiang University CAS Key Laboratory of Receptor Research, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Pudong, Shanghai 201203, China; School of Pharmaceutical Science and Technology, Hangzhou Institute of Advanced Study, Hangzhou 310024, China; University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing 100049, China College of Chemistry and Pharmacy, Shaanxi Key Laboratory of Natural Products & Chemical Biology, Northwest A&F University, 3 Taicheng Road, Yangling, Xianyang 712100, Shaanxi, P. R. China College of Sciences, Northeastern University, Shenyang, Liaoning 110819, China; Key Laboratory of Ministry of Education on Safe Mining of Deep Metal Mines, Northeastern University, Shenyang, Liaoning 110819, China Department of Cardiology, Huashan Hospital, Fudan University Dept. of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Wuhan University, Wuhan 430079, China. College of Applied Sciences, Beijing University of Technology, Beijing, P. R. China Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Melbourne, Victoria, Australia Fu Dan University alliliated Hui Dong Hospital, Shanghai 200040, China Department of Urology Tianjin Union Medical Center Tianjin China Jinling Pharmaceutical Co., Ltd. Nanjing 210009, China. Facility for Anti-infective Drug Development and Innovation, Drug Delivery, Disposition and Dynamics Department of Pediatrics, The Second Xiangya Hospital, Central South University, Changsha 410011, Hunan, China; Childern’s Brain Development and Brain Injury Research Office, The Second Xiangya Hospital, Central South University, Changsha 410011, Hunan, China Xi A Modern Chemistry Research Institute Section of Orthopedics, Department of Surgical Sciences, Karolinska Institute, Stockholm, Sweden 1Peking University Cancer Hospital & Institute, Beijing, China. College of Life Sciences, Hunan Normal University, Changsha 410081, People's Republic of China; Technical Service Parlor, Unit 31434 of the Chinese People’s Liberation Army, Shenyang 110000, China Department of Biochemistry and Molecular Biology School of Basic Medical Sciences Cheeloo College of Medicine Shandong University Jinan Shandong 250012 China Department of Orthopedics, West China Hospital, Sichuan University, Chengdu, China Department of Hematology Peking Union Medical College Hospital Beijing China Beijing University of Chinese Medicine; Beijing 100029, China *The Wistar Institute, Philadelphia, PA 19104; State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Key Laboratory of Science and Technology of Eco-Textile, Ministry of Education, College of Chemistry and Chemical Engineering, Donghua University, Shanghai 201620, China State Key Laboratory on Lead Compound Research, Wuxi AppTec Co., Ltd., Shanghai, China From the Department of Interventional Oncology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education) (X.W., J.H., G.C., X.Z., R.Y., H.C., H.X., P.L.), Departments of Radiology (Y.C.), Medical Statistics (X.J.), and GI Oncology (Jian Li, Jie Li, L.S.), and Department of Hepatic, Biliary & Pancreatic Surgery (C.H., B.X.), Peking University Cancer Hospital & Institute, 52 Fucheng Road, Haidian District, Beijing 100142, China; and Department of Mathematics and... School of Pharmacy, East University of Science and Technology, Shanghai 200237, People’s Republic of China Department of Chemistry, Innovative Drug Research Center, Shanghai University, 99 Shangda Road, Shanghai 200444, P. R. China; Shanghai Key Laboratory of High Temperature Superconductors, Shanghai University, Shanghai 200444, P. R. China Dept. of Chemical and Biological Engineering University of Wisconsin-Madison Madison WI USA State Key Laboratory of Drug Research, CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203, China; College of Pharmacy, Nanjing University of Chinese Medicine, 138 Xianlin Avenue, Qixia District, Nanjing, 210023, China Department of Hepato‑Biliary‑Pancrease, Institute of General Surgery, The Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan 639000, P.R. China Department of Obstetrics and Gynecology, First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin, China. Department of Nuclear Medicine, Xiangya Hospital, Central South University, Changsha, Hunan, China College of Life Sciences, Hunan Normal University, Changsha 410081, China Department of Hematology and Institute of Hematology West China Hospital, Sichuan University Chengdu China Key Laboratory for Animal Disease‐Resistance Nutrition of the Ministry of Agriculture of China, Institute of Animal Nutrition Sichuan Agricultural University Ya′an Sichuan 625014 China Department of Hematology, Fujian Institute of Hematology Fujian Medical University Union Hospital Fuzhou China Key Lab of Organic Optoelectronics and Molecular Engineering, Department of Chemistry, Tsinghua University, Beijing 100084, China Monash Biomedicine Discovery Institute and Department of Microbiology, Monash University, Australia Institute of Human Genetics, Aarhus University, Aarhus C, Denmark. jianl@humgen.au.dk Department of Biological Sciences and; Molecular and Cellular Biology Graduate Program, Ohio University, Athens, OH 45701 Contribution from the Department of Molecular Biology TPC-15, The Scripps Research Institute, La Jolla, California 92037 Beijing Institute of Radiation Medicine, Beijing 100850, China. Center for Gene Regulation, Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania 16802 Department of Cardiology, The Second People’s Hospital of Yibin, Yibin, Sichuan, China (mainland) Department of Nuclear Medicine (PET Center) Xiangya Hospital Central South University Changsha China; Mallinckrodt Institute of Radiology Washington University School of Medicine St. Louis MO USA College of Pharmaceutical Sciences, Gannan Medical University, Ganzhou 341000, China College of Information and Computer Sciences, University of Massachusetts, Amherst, MA, USA State Key Laboratory of Bioorganic and Natural Products Chemistry Collaborative Innovation Center of Chemistry for Life Sciences Shanghai Institute of Organic Chemistry Chinese Academy of Sciences 345 Lingling Road Shanghai 200032 China Department of Gastroenterology, Ruijin Hospital, Luwan Branch, Shanghai Jiaotong University School of Medicine, Shanghai, China Endoscopy Center and Endoscopy Research Institute, Zhongshan Hospital, Fudan University, Shanghai 200032, P.R. China Hubei Collaborative Innovation Centre for Advanced Organic Chemical Materials and Ministry of Education Key Laboratory for the Green Preparation and Application of Functional Materials; Hubei University; Wuhan 430062; People's Republic of China; State Key Laboratory of Solid Lubrication Research Institute of Qinghai–Tibetan Plateau, Southwest University for Nationalities, Chengdu, Sichuan, 610041, China. National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China. Department of Orthopaedics China Aerospace Science & Industry Corporation Hospital 731 Beijing China; Department of Orthopaedics The Third Medical Center of PLA General Hospital Beijing China School of Materials Science and Engineering; State Key Laboratory of Material Processing and Die & Mould Technology; Huazhong University of Science and Technology; Wuhan, China Monash Biomedicine Discovery Institute and Department of Microbiology, Monash University, Victoria, Australia Cancer Center, Institute of Surgical Research, Daping Hospital, Third Military Medical University, Chongqing 400042, P.R. China Department of Endocrinology, Liaocheng People's Hospital, Liaocheng, Shandong 252000, P.R. China Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University, Tianjin, People's Republic of China Discovery Services, WuXi AppTec Co., Ltd., Waigaoqiao Free Trade Zone, Shanghai, 200131 China Department of Chemistry and Chemical Biology, McMaster University, Hamilton, Ontario, Canada L8S 4M1 Center of Prenatal Diagnosis, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China. qihongbo728@163.com. Prenatal Diagnostic Center, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, Guangdong Province, People’s Republic of China Department of Geriatric Endocrinology, Chinese PLA General Hospital, Beijing 100853, China Department of Prenatal Diagnostic Center, Guangzhou Women and Children’s Medical Centre, Guangzhou Medical University, Guangzhou, P.R. China Graduate School of Peking Union Medical College and Chinese Academy of Medical Sciences.; The Key Laboratory of Geriatrics, Beijing Hospital & Beijing Institute of Geriatrics, Ministry of Health. Department of Oncology Shanghai Fourth People's Hospital, Tongji University School of Medicine Shanghai China Sports Medicine Center West China Hospital, Sichuan University Chengdu China Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine, Beijing, China. The Ministry of Health Key Laboratory of Geriatrics, Beijing Hospital, National Center of Gerontology, Beijing, China 2 Sports Medicine Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China; Department of Orthopedics and Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu, Sichuan, China Peoples’ Hospital of Pubei, Pubei, China Department of Operation Management, West China Hospital of Sichuan University, Chengdu, China. Beijing National Laboratory for Molecular Science (BNLMS); State Key Laboratory of Rare Earth Materials Chemistry and Applications; College of Chemistry and Molecular Engineering; Peking University; Beijing 100871 Key Laboratory of Systematic Mycology & Lichenology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100190, People's Republic of China, Graduate School of Chinese Academy of Sciences, Beijing 100039, People's Republic of China, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China, and Beijing Institute of Pharmacology & Toxicology, Beijing 100850, People's Republic of China Department of Orthopaedics, the Third Affiliated Hospital of Guangzhou Medical University. Department of Molecular Biosciences, and the Feinberg School of Medicine, ‡Department of Chemistry, and §Department of Chemical and Biological Engineering, Northwestern University, Evanston, Illinois 60208, United States State Key Laboratory of Stem Cell and Reproductive Biology Institute of Zoology Chinese Academy of Sciences Beijing China; Department of Reproductive Medicine Peking University Shenzhen Hospital Shenzhen Peking University‐The Hong Kong University of Science and Technology Medical Center Shenzhen China School of Chinese Materia Medica, Nanjing University of Chinese Medicine, 138 Xianlin Avenue, Nanjing, 210023, China; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai, 201203, China School of Basic Medical Sciences, Beijing University of Chinese Medicine, Beijing 100029, P.R. China University of Science and Technology of China Brainnetome Center and National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing, China State Key Laboratory of Grassland Agro‐ecosystems, Key Laboratory of Grassland Livestock Industry Innovation, Ministry of Agriculture and Rural Affairs, Engineering Research Center of Grassland Industry, Ministry of Education, College of Pastoral Agriculture Science and Technology Lanzhou University Lanzhou 730020 P. R. China Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, School of Pharmaceutical Sciences, Wuhan University, Wuhan, 430071, China R&D Center, Wuhan Research Institute of Materials Protection, 126 Bao Feng Erlu, Wuhan, Hubei 430030, China; Hubei Key Laboratory of Materials Surface Protection Technology, 126 Bao Feng Erlu, Wuhan, Hubei 430030, China College of Ecology and Environment, Zhengzhou University, Zhengzhou 450001, China Department of Hematology Oncology, Children’s Hospital of Nanjing Medical University, Nanjing, China Center for Fuel Cell Innovation School of Materials Science and Engineering Huazhong University of Science & Technology Wuhan 430074 China Facility for Anti-infective Drug Development and Innovation, Monash Institute of Pharmaceutical Sciences, Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia Department of Acute Infectious Disease, Shanghai Municipal Center for Disease Control and Prevention, Shanghai 200336, China. School of Automation, Beijing Institute of Technology, Beijing, China. Key Laboratory of Bio-Based Material Science and Technology (Ministry of Education), College of Material Science and Engineering, Northeast Forestry University, Hexing Road 26, Harbin 150040, P. R. China Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China Drug Delivery, Disposition, and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia Department of Clinical Research Center, Rui Jin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200025, China Laboratory of General Surgery, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, China; State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou 510060, China; Department of Clinical Laboratory, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, China Department of Chemistry, Shanghai University, Shanghai, 200444, P. R. China, and State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, 730000, P. R. China Heart Center, First Hospital of Tsinghua University, Beijing, China Department of Blood Transfusion, the Third Xiangya Hospital, Central South University, Changsha 410013, P. R. China Departments of Chemistry and Materials Science, University of Southern California, Los Angeles, California 90089 Department of Hepatobiliary Surgery, YouAn Hospital Affiliated to Capital Medical University, Beijing, China; Department of Hepatobiliary Surgery, Hospital Affiliated to Chengde Medical University,Chengde, China Department of Sports Medicine, Shanghai University of Sport, Shanghai, China. School of Physics and Electrical Engineering, Jishou University, Jishou 416000, P. R. China Key Lab of Organic Optoelectronics & Molecular Engineering, Department of Chemistry, Tsinghua University, Beijing 100084, China Department of Gastrointestinal Surgery, Henan Provincial Cancer Hospital, Zhengzhou University, Zhengzhou 450008, China. Key Laboratory of Sustainable Development of Marine Fisheries, Ministry of Agriculture, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences 106 Nanjing Road Qingdao 266071 China Animal Nutrition Institute; Sichuan Agricultural University; Ya'an 625014; People's Republic of China; Key Laboratory for Animal Disease-Resistance Nutrition Key laboratory of Carcinogenesis and Translational Research (Ministry of Education) Department of GI Oncology Peking University Cancer Hospital & Institute Beijing China Cell Biochemistry Laboratory, Basic Medicine College, Beijing University of Traditional Chinese Medicine, Beijing 100029, China. State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China; University of Chinese Academy of Sciences, Beijing, China Beijing University of Chinese Medicine, Beijing 100700, China Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China Department of Oncology, Shanghai Fourth People’s Hospital, Tongji University School of Medicine, Shanghai 200434, China The MOH Key Laboratory of Geriatrics Beijing Hospital National Center of Gerontology Beijing China Key Laboratory of Bio-based Material Science and Technology, Ministry of Education; Northeast Forestry University; Harbin 150040; China State Key Laboratory of Precision Measuring Technology and Instruments, Tianjin University, Tianjin 300072, China Beijing Institute of Veterinary Drugs Control, Beijing 102206, People's Republic of China Department of Hematology, Peking Union Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China. E-mail: pumch.li.jian@gmail.com. 2Department of Orthopedics, Changhai Hospital, Second Military Medical University, Shanghai; and Uropath Pty Ltd and School of Pathology and Laboratory Medicine, University of Western Australia, Western Australia, Australia School of Chemistry and Materials Science; Key Laboratory of Chemical Engineering Process & Technology for High-efficiency Conversion; Heilongjiang University; China From the Institute of Molecular Medicine, Peking University, Beijing, China (X.A., Y.J., J.L.), and Divisions of Cardiovascular Medicine (X.A., Y.J., H.G., S.-Y.F., B.L.C., J.W., A.R., J.L.) and Molecular and Vascular Medicine (H.Z.), Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Mass. From the Center for Minimally Invasive Surgery, Harvard Medical School, Boston, MA (M.R.); and the Division of Cardiothoracic Surgery (M.R., T.A.K., P.V., C.B., Jianyi Li, F.W.S.) and the Division of Cardiology (G.F.W., Jian Li, R.J.L.), Beth Israel Deaconess Medical Center, Boston, MA. School of Materials Science and Engineering, Huazhong University of Science and Technology, Wuhan, Hubei 430074, P. R. China Department of Blood Transfusion, Third Xiangya Hospital, Central South University, Changsha 410013, China 990297364@qq.com. Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong; Zhejiang University School of Medicine, Department of Ophthalmology, Affiliated Hangzhou First People’s Hospital, Hangzhou, China Department of Haematology Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China Department of Orthopaedic Surgery, West China Hospital, Sichuan University, Chengdu 610041, China. School of Chemistry and Chemical Engineering Nanjing University Nanjing 210023 China Department of Orthopedics, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, P. R. China Department of Cardiology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China (mainland) College of Mathematics and Big Data, Guizhou Education University, Guiyang 550018, China Osteoporosis Research Center and Department of Biomedical Sciences, Creighton University, Omaha, Nebraska 68131 State Key Laboratory of Power Transmission Equipment & System Security and New Technology, School of Electrical Engineering, Chongqing University, Chongqing 400044, China Jiangxi Province Key Laboratory for Ecological Diagnosis-Remediation and Pollution Control, Nanchang Hangkong University, China. lijian@nchu.edu.cn Department of Otorhinolaryngology, Cangzhou Central Hospital, Cangzhou, Hebei, China Key Laboratory for Oral Biomedical Engineering of Ministry of Education, School of Stomatology, Wuhan University, Wuhan 430079, China. School of Psychology Beijing Normal University Beijing China; Beijing Key Lab of Applied Experimental Psychology Beijing Normal University Beijing China Monash Biomedicine Discovery Institute, Infection and Immunity Program and Department of Microbiology Monash University Clayton Victoria Australia Department of Pathology, The Second Hospital of Jilin University, Changchun, Jilin, China (mainland) School of Pharmaceutical Science and Technology, Key Laboratory for Modern Drug Delivery & High-Efficiency, and ‡Collaborative Innovation Center of Chemical Science and Engineering, Tianjin University, Tianjin 300072, People’s Republic of China Department of Pathophysiology, College of High Altitude Military Medicine, Third Military Medical University, Chongqing 400038, P.R. China Department of Plastic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China Key Laboratory of Photochemical Conversion and Optoelectronic Materials Technical Institute of Physics and Chemistry the Chinese Academy of Sciences Beijing 100190 P. R. China Department of Biochemistry, Stanford University School of Medicine, Stanford, CA, 94305-5307, USA. Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104 Oncology Research Team, High Throughput Chemistry Team, Molecular Design and Informatics Team, Analytical Research Team, Johnson & Johnson Pharmaceutical Research and Development, L.L.C., Spring House Research and Early Development Site, Welsh and McKean Roads, Spring House, Pennsylvania 19477, and Cancer Therapeutics Team, Johnson & Johnson Pharmaceutical Research and Development, L.L.C., Raritan Research and Early Development Site, Route 202, Raritan, New Jersey 08869 Joseph Henry Laboratories of Physics, Department of Physics, Princeton University, Princeton, NJ 08540, USA. General Hospital of Southern Theatre of PLA Guangzhou China School of Environmental and Municipal Engineering, Lanzhou Jiaotong University, Lanzhou 730070, China The Key Laboratory of Myocardial Ischemia; Harbin Medical University; Ministry of Education; Heilongjiang Province; China Department of Chemical and Biological Engineering, Center for Synthetic Biology, Northwestern University, Evanston, Illinois 60208, United States State Key Laboratory of Food Nutrition and Safety, Tianjin University of Science and Technology, Tianjin 300457, China; Key Laboratory of Industrial Fermentation Microbiology, Ministry of Education, College of Biotechnology, Tianjin University of Science and Technology, Tianjin 300457, China Material Science and Engineering College, Northeast Forestry University, Harbin 150040, China Department of Chemistry, Innovative Drug Research Center, Shanghai University, Shanghai 200444, China Department of Diagnostic and Interventional Ultrasound Sun Yat‐Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine Guangzhou China School of Basic Medicine, The Fourth Military Medical University, Xi’an, Shaanxi, China Department of Respirology, the Affiliated Hospital, Jiangsu University, Zhenjiang. lijian541226@163.com Orthopedic Department of West China Hospital, Sichuan University, Chengdu, PR China Key Laboratory of Sustainable Development of Marine Fisheries, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao, People's Republic of China Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Gastrointestinal Oncology, Peking University Cancer Hospital and Institute, Beijing 100142, China. linshenpku@163.com. National Engineering Research Center of Electromagnetic Radiation Control Materials and State Key Laboratory of Electronic Thin Films and Integrated Devices, School of Microelectronics and Solid State Electronics, University of Electronic Science and Technology of China, Chengdu 610054, China Department of Spinal Surgery, Jinan Central Hospital Affiliated to Shandong University, Jinan, China. Department of Cardiovascular Medicine, The First Hospital of China Medical University , No. 155 Nanjing North Street, Heping District, Shengyang 110001, Liaoning Province , China Department of Anesthesia Chinese Academy of Medical Sciences Shenzhen China College of Animal and Veterinary Sciences, Southwest Minzu University, Chengdu, China; Key Laboratory of Qinghai-Tibetan Plateau Animal Genetic Resource Reservation and Utilization, Ministry of Education, Chengdu, China; Key Laboratory of Qinghai-Tibetan Plateau Animal Genetic Resource Reservation and Utilization, Chengdu, Sichuan Province, China; Key Laboratory for Animal Science of National Ethnic Affairs Commission, Chengdu, Sichuan, China Department of Chemistry Capital Normal University Beijing China Key Laboratory of Photochemical Conversion and Optoelectronic Materials and CityU‐CAS Joint Laboratory of Functional Materials and Devices Technical Institute of Physics and Chemistry Chinese Academy of Sciences Beijing 100049 P. R. China; School of Future Technology University of Chinese Academy of Sciences Beijing 100049 China Drug Development and Innovation, Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, VIC 3052, Australia Facility for Anti-Infective Drug Development and Innovation, Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Melbourne, Victoria 3052, Australia Hepatobiliary and Enteric Surgery Research Center, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China Key laboratory of Carcinogenesis and Translational Research (Ministry of Education) Department of GI Oncology Peking University School of Oncology Beijing Cancer Hospital & Institute Beijing 100142 China Frontier Institute of Science and Technology and State Key Laboratory for Mechanical Behavior of Materials, Xi’an Jiaotong University, Xi’an 710049, China Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, 130 Mei Long Road, Shanghai 200237, China The Affiliated Cancer Hospital of Nanjing Medical University, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Nanjing, Jiangsu 210000, P.R. China State Key Laboratory of Applied Organic Chemistry; Key Laboratory of Nonferrous Metals Chemistry and Resources Utilization of Gansu Province and College of Chemistry and Chemical Engineering; Lanzhou University; Lanzhou 730000; China Nanjing University of Posts and Telecommunications; Broadband Wireless Communication and Sensor Network Technology; National Engineering Research Center Authors' Affiliations: Departments of 1Medicine, 2Chemistry, 3Molecular and Cellular Biology, and 4Applied Mathematics, and 5Bioinformatics Facility, Stony Brook University, Stony Brook, New York; and 6Department of Research, Veterans Affairs Medical Center, Northport, New York Department of Thoracic Surgery, Peking University First Hospital Peking University Peking China Department of Microbiology, Monash Biomedicine Discovery Institute, Monash University, Parkville, Australia. Triticeae Research Institute, Sichuan Agricultural University, Wenjiang, Chengdu 611130, Sichuan, P.R. China. State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources; Guangxi Normal University; Guilin 541004; China Department of Psychology and Beijing Key Laboratory of Behavior and Mental Health; PKU-IDG/McGovern Institute for Brain Research, Peking University Department of Human Genetics, University of Aarhus, The Bartholin Building, DK-8000, Aarhus C, Denmark. Monash Biomedicine Discovery Institute, Department of Microbiology, Monash University, Clayton, Victoria 3800, Australia Department of Head and Neck Surgery Cancer Hospital of China Medical University Liaoning Cancer Hospital and Institute Shenyang China Department of Chemistry, Innovative Drug Research Center, Shanghai University, 99 Shangda Road, Shanghai 200444, China From the Division of Cardiothoracic Surgery and Cardiology (J.L., R.L.), Beth Israel Deaconess Medical Center, Boston, Mass. School of Pharmacy, Institute of Cell and Molecular Biology, Harbin University of Commerce, Harbin, Heilongjiang 150076, P.R. China College of Materials Science and Engineering; Shenzhen University; Shenzhen 518060; China Prenatal Diagnostic Center, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, People’s Republic of China School of Environmental and Chemical Engineering, Shanghai University; Department of Chemistry, Shanghai University Department of Otorhinolaryngology-Head and Neck Surgery, Sun Yat-Sen University First Afliated Hospital, Guangzhou, China Life College, Nankai University, Tianjin 300071, China. School of Material Science and Engineering, Beijing Institute of Technology, Beijing 100081, China Department of Hematology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China Monash Institute of Pharmaceutical Sciences; Parkville; Australia Endoscopy Unit Department of Gastroenterology Shenzhen Affiliated Hospital Guangzhou University of Traditional Chinese Medicine Shenzhen China School of Computer Science and Technology, Harbin Institute of Technology, Harbin, 150001, China; School of Economics and Management, HuBei University of Automotive Technology, Shiyan, 442002, China Center of Implant Dentistry Capital Medical University School of Stomatology and Beijing Stomatological Hospital Capital Medical University Beijing China Institute of Occupational, Social and Environmental Medicine, Centre for Health and Society, Faculty of Medicine, University of Düsseldorf, Germany; Department of Environmental Health Sciences, Fielding School of Public Health, School of Nursing, University of California Los Angeles, USA State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 P. R. China; School of Applied Chemistry and Engineering University of Science and Technology of China Hefei 230026 Anhui P. R. China CSIRO Mineral Resources Perth, Processing Program, 7 Conlon St., Waterford, Western Australia 6152, Australia School of Fisheries and Life Science Shanghai Ocean University Shanghai China; Key Laboratory of Sustainable Development of Marine Fisheries Ministry of Agriculture Yellow Sea Fisheries Research Institute Chinese Academy of Fishery Sciences Qingdao Shandong China Center for Translational Medicine Research and Development Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences Shenzhen Guangdong 518055 China Key Laboratory of Coal Clean Conversion and Chemical Process Autonomous Region, School of Chemical Engineering and Technology, Xinjiang University, Urumqi 830000, China Department of Clinical Laboratory of the Third Xiangya Hospital, Central South University, Hunan 410013, China Department of Orthopaedics, the First Affiliated Hospital of University of South China, Hengyang, Hunan, China Jiangsu University School of material science and engineering, , Zhenjiang 212013, People’s Republic of China Kent State University, Kent, Ohio, USA Department of Physics and Astronomy, Wright Center for Photovoltaics Innovation and Commercialization The University of Toledo Toledo Ohio 43606 United States Fujian Provincial Key Laboratory on Hematology, Department of Pediatric Hematology Berzelii Center EXSELENT on Porous Materials, Department of Materials and Environmental Chemistry, Stockholm University, Stockholm 10691, Sweden; Department of Fibre and Polymer Technology, KTH Royal Institute of Technology, Teknikringen 56, Stockholm 10044, Sweden Department of Neurosurgery, The First Affiliated Hospital of Bengbu Medical College, Bengbu, China State Key Laboratory of Bioorganic and Natural Products Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China Institute of Life Science, Chongqing Medical University, Chongqing, PR China Department of Molecular Biology TPC-15, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, Johnson & Johnson Pharmaceutical Research and Development LLC, Welsh and McKean Roads, P.O. Box 776, Spring House, Pennsylvania 19477, and Theoretical Chemistry, Department of Biotechnology, Royal Institute of Technology, ALBANOVA, S-106 91 Stockholm, Sweden Key Laboratory of DGHD, MOE, School of Life Science and Technology, Southeast University, Nanjing210096, People’s Republic of China Department of Heavy Metal Pollution and Cancer Prevention Technology Research Center, Affiliated Hospital of Xiangnan University (Clinical College), Chenzhou, Hunan 423000, P.R. China Department of Chemistry, Shangqiu Normal University, Shangqiu 476000, People's Republic of China Clinical Research Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China Key Laboratory of Functional Polymer Materials of the Ministry of Education and College of Chemistry, Nankai University, Tianjin 300071, P. R. China Key Laboratory of Bio‐based Material Science and Technology of Ministry of Education, Northeast Forestry University,150040 Harbin, China; Key Laboratory of Molecular Medicine, the Second Affiliated Hospital of Jiangxi Medical College, Nanchang 330006, P.R. China. Department of Environmental Health Sciences, Fielding School of Public Health, School of Nursing, University of California Los Angeles, Los Angeles, California, USA Technology and Research (A*STAR) 1 Institute of Materials Research and Engineering, Agency for Science, , Singapore, 117602 Hubei Communications Planning and Design Institute Co., Ltd., Wuhan 430051, China 2 Department of Biostatistics and Bioinformatics and College of Food and Biological Engineering Jimei University Xiamen China Molecular Diagnostics Laboratory, Department of Genetics, Prenatal Diagnosis Center of Xiamen, Maternal and Child Health Hospital of Xiamen, Xiamen, Fujian, China Monash Biomedicine Discovery Institute and Department of Microbiology, Monash University , Melbourne, VIC 3800 , Australia Department of Dermatology, Southwest Hospital, Army Medical University, Chongqing 400038, China Sichuan Industrial Institute of Antibiotics, Chengdu University, Chengdu, China; School of Medicine, Chengdu University, Chengdu, China Department of Fibre and Polymer Technology, KTH Royal Institute of Technology, Stockholm10044, Sweden Department of Orthopedics, Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu 610041, China Key Laboratory of Bio-Based Material Science and Technology, Ministry of Education, Northeast Forestry University, Harbin 150040, P. R. China Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Zhengzhou University; Institute of Hepatobiliary and Pancreatic Diseases, Zhengzhou University; Zhengzhou Basic and Clinical Key Laboratory of Hepatopancreatobiliary Diseases Faculty of Arts and Humanities, University of Macau, Macao, China Department of Reproductive Medicine Peking University Shenzhen Hospital Shenzhen China Key Laboratory for Animal Disease Resistance Nutrition of the Ministry of Education of China Animal Nutrition Institute Sichuan Agricultural University Ya'an China 1 Department of Electrical Engineering, Stanford University, Stanford, CA 94035, USA, 2Department of Bioinformatics, Bina Technologies, Redwood City, CA 94065, USA, 3Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT 06520, USA, 4Mayo Clinics, Department of Health Sciences Research, Rochester, MN 55902, USA, 5Department of Statistics, Stanford University, Stanford, CA 94035, USA and 6Department of Health Research and Policy, Stanford University, Stanford, CA 94035, USA Key Laboratory of Qinghai-Tibetan Plateau Animal Genetic Resource Reservation and Utilization, Ministry of Education, Chengdu, Sichuan, China; College of Animal & Veterinary, Southwest Minzu University, Chengdu, Sichuan, China State Key Laboratory of Drug Research, CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.; College of Pharmacy, Nanjing University of Chinese Medicine, Qixia District, Nanjing 210023, China. Key Laboratory of Nuclear Medicine of Ministry of Health; Jiangsu Institute of Nuclear Medicine; Wuxi; China Department of Cardiology Huashan Hospital Fudan University Shanghai China Department of Basic Medicine, Xiangnan College of Medicine, Hunan Province, Chenzhou 423000, China.E-mail: okleonlj@163.com. School of Chemical Engineering and Technology, Tiangong University, Tianjin300387, China; State Key Laboratory of Separation Membranes and Membrane Processes, Tiangong University, Tianjin300387, China Department of Gastroenterology and Hepatology National Medical Products Administration Beijing China Eppley Institute for Research in Cancer and Allied Diseases, Fred and Pamela Buffett Cancer Center University of Nebraska Medical Center Omaha Nebraska USA College of Water Sciences, Beijing Normal University, Beijing 100875, China. lijian@bnu.edu.cn School of Science, Westlake Univeristy, Hangzhou 310024, China Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Victoria, Australia Shanghai Entry-Exit Inspection and Quarantine Bureau, Shanghai, China. lijiancq@yahoo.com.cn Department of General Surgery, Xiangya Hospital, Central South University, No. 87 Xiangya Road, Changsha, Hunan 410008, China Division of Rheumatology, Inflammation and Immunity, Brigham and Women’s Hospital, and Department of Medicine, Harvard Medical School, Boston, MA 02115; Department of Radiation Oncology Harbin Medical University Cancer Hospital Harbin China Department of Gastrointestinal Oncology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital and Institute, Beijing, China (mainland) State Key Laboratory of Rare Earth Resource Utilization; Changchun Institute of Applied Chemistry; Chinese Academy of Sciences; Changchun 130022; P. R. China Department of Gastrointestinopancreatic Surgery, The First Affiliated Hospital, Sun Yet-sen University, Guangzhou 510080, China. Department of Orthopedic Surgery, West China Hospital, Sichuan University, Chengdu, China Research Center of Green Chirality, College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310032, China, Institute of Environmental Science, Zhejiang University, Hangzhou 310027, China, and School of Chemical Engineering and Pharmacy, Wuhan Institute of Technology, Wuhan 430073, China Beijing Hospital, National Center of Gerontology, Beijing, China Department of Radiation Oncology, The Second Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530000, P.R. China Department of Microbiology, Monash Biomedicine Discovery Institute, Monash University, Clayton, Victoria 3800, Australia Department of Dermatology, Southwest Hospital, Army Medical University, Chongqing, China. Division of Rheumatology, Inflammation and Immunity, Brigham and Women’s Hospital and Department of Medicine, Harvard Medical School, Boston, MA 02115 Department of Statistics, North Carolina State University, Raleigh, North Carolina 27695 College of Biological Science and Engineering, Jiangxi Agricultural University, Nanchang 330045, China. Department of Dermatology Huashan Hospital, Fudan University Shanghai China Clinical Laboratory Center, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China Institute of Hepatopancreatobiliary Surgery, Southwest Hospital, Third Military Medical University, Chongqing 400038, PR China Hematology Department of Chemistry and Chemical Engineering; Weifang University; Weifang 261061; China Institute of Crop Sciences Chinese Academy of Agricultural Sciences Beijing 100081 China; College of Agronomy Jilin Agricultural University Changchun Jilin 130118 China Institute of Environment and Ecology, Academy of Environmental Health and Ecological Security, School of the Environment and Safety Engineering, Jiangsu University, Zhenjiang 212013, China Key Laboratory of Qinghai-Tibetan Plateau Animal Genetic Resource Reservation and Utilization, Qinghai-Tibetan Plateau Animal Genetic Resource Reservation and Utilization Key Laboratory of Sichuan Province, Ministry of Education, Southwest Minzu University, Chengdu, Sichuan, China; College of Animal & Veterinary, Southwest Minzu University, Chengdu, Sichuan, China Second Clinical Medical College, Shanxi Medical University, Taiyuan, ShanXi, China Department of Cardiology, Huashan Hospital, Fudan University, Shanghai, China Department of Molecular Biology, TPC-15, The Scripps Research Institute, La Jolla, California 92037 Center for NeuroGenetics, College of Medicine, University of Florida, Gainesville, FL 32610;; Department of Molecular Genetics & Microbiology, College of Medicine, University of Florida, Gainesville, FL 32610;; Genetics Institute, University of Florida, Gainesville, FL 32610; Department of Lymphoma, State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Disease Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300020, P.R. China 4 Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia China-US(Henan) Hormel Cancer Institute, Zhengzhou, China Tangshan Gongren Hospital, Tangshan, Hebei, China The Center for Genome Architecture, Baylor College of Medicine, Houston, TX 77030;; Center for Theoretical Biological Physics, Rice University, Houston, TX 77030; Faculty of Aerospace Engineering; Technion – Israel Institute of Technology; Haifa 32000; Israel Biomedicine Discovery Institute, Monash University , Melbourne, Victoria , Australia Beijing National Laboratory for Molecular Sciences State Key laboratory for Structural Chemistry of Unstable and Stable Species College of Chemistry and Molecular Engineering Peking University Beijing 100871 China National Key Laboratory of Wheat Improvement, Peking University Institute of Advanced Agricultural Sciences, Shandong Laboratory of Advanced Agriculture Sciences in Weifang , China Department of GI Oncology, Laboratory of Carcinogenesis & Translational Research for the Ministry of National Education, Peking University School of Oncology, Beijing Cancer Hospital & Institute, Beijing 100142, PR China Department of Pulmonary Medicine, Affiliated Hospital of Jiangsu University, Zhenjiang, China Department of Cardiothoracic Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou 563000, P.R. China Department of Gastrointestinal Oncology, Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education), Peking University Cancer Hospital and Institute, Beijing 100142, China. lin100@medmail.com.cn Department of Oral and Maxillofacial Surgery School and Hospital of Stomatology Wuhan University Wuhan Hubei China Department of Preventive Dentistry, School and Hospital of Stomatology, China Medical University, Liaoning Provincial Key Laboratory of Oral Diseases, Shenyang 110002, China Key Laboratory of Animal Disease-Resistant Nutrition of Ministry of Education, Animal Nutrition Institute, Sichuan Agricultural University, Chengdu 611130, China The Reproductive Medicine Center, Peking University Shenzhen Hospital, Shenzhen Peking University-The Hong Kong University of Science and Technology Medical Center, Shenzhen, China Department of Acute Infectious Disease, Shanghai Municipal Center for Disease Control and Prevention, Shanghai 200336, China; Department of Maternal and Children Health, School of Public Health, Fudan University. Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai, China, School of Basic Medical Science, Beijing University of Chinese Medicine, Chaoyang District, Beijing 100029, China Frontier Laboratory of System Crop Design, Beijing 102206, China; Department of Sports Medicine, West China Hospital, Sichuan University, Chengdu, China. State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, Lanzhou 730000, P. R. China State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology Shanghai, China. Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110016, PR China College of Chemistry and Molecular Engineering, Beijing National Laboratory for Molecular Sciences, Peking University, Beijing 100871, China. The Ministry of Health Key Laboratory of Geriatrics, Beijing Hospital, National Center of Gerontology, Beijing 100730, P.R. China Key Laboratory of Bio-Based Material Science & Technology (Ministry of Education), Northeast Forestry University, Harbin 150040, China. From the Institute of Molecular Medicine, Peking University, Beijing, China (X.A., Y.J., J.L.); and Cardiovascular Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA (X.A., Y.J., M.J.P., J.W., A.M.-B., X.S., B.L.C., P.H., M.X., H.S.D., J.L.). Department of General Surgery The Affiliated Cancer Hospital of Nanjing Medical University and Jiangsu Cancer Hospital and Jiangsu Institute of Cancer Research Nanjing China Hubei Subsurface Multi-scale Imaging Key Laboratory, Institute of Geophysics and Geomatics China University of Geosciences 388 Lu Mo Road Wuhan 430074 People's Republic of China Technical Center for Animal, Plant and Food Inspection and Quarantine, Shanghai Entry-Exit Inspection and Quarantine Bureau, Shanghai, China. a Department of Epidemiology and Community Health , Virginia Commonwealth University , Richmond , VA , USA Material Science and Engineering College; Northeast Forestry University; Harbin 150040; P. R. China College of Chemistry and Chemical Engineering, Xinjiang Normal University, Urumqi, 830054, Xinjiang, China; Xinjiang Key Laboratory of Energy Storage and Photoelectrocatalytic Materials, Urumqi, 830054, Xinjiang, China Prenatal Diagnostic Center, Guangzhou Women and Children Medical Center affiliated to Guangzhou Medical University, Guangzhou, People’s Republic of China College of Animal and Veterinary Sciences, Southwest Minzu University, Chengdu 610041, China; Key Laboratory of Qinghai-Tibetan Plateau Animal Genetic Resource Reservation and Utilization, Ministry of Education, Qinghai-Tibetan Plateau Animal Genetic Resource Reservation and Utilization Key Laboratory of Sichuan Province, Chengdu 610041, China; Key Laboratory of Animal Science of National Ethnic Affairs Commission of China, Southwest Minzu University, Chengdu 610041, China BGI-Shenzhen; Shenzhen; China; Department of Biology; University of Copenhagen; Copenhagen Denmark Université Paris-Saclay UMR 8000 CNRS Institut de Chimie Physique 91405 Orsay France Key Laboratory for Animal Disease Resistance Nutrition of the Ministry of Education Animal Nutrition Institute Sichuan Agricultural University Chengdu China Department of Biomedical Engineering City University of Hong Kong Hong Kong P. R. China; Hong Kong Center for Cerebra‐Cardiovascular Health Engineering Hong Kong Science Park New Territories Hong Kong P. R. China School of Life Sciences Fujian Agriculture and Forestry University Fuzhou 350002 China Department of Urology, Tianjin Union Medical Center, Tianjin, China Department of Gastrointestinal Oncology Key Laboratory of Carcinogenesis and Translational Research Peking University Cancer Hospital and Institute Beijing China Sun Yat‐sen University Cancer Center State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Guangzhou Guangdong P.R. China; Department of Diagnostic and Interventional Ultrasound Sun Yat‐Sen University Cancer Center Guangzhou Guangdong P.R. China Department of Sports Medicine and Adult Reconstruction, Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210008, Jiangsu, China. Biomedicine Discovery Institute, Infection and Immunity Program and Department of Microbiology, Monash University, Clayton, Victoria 3800, Australia State Key Laboratory of Power Transmission Equipment and System Security and New Technology, School of Electrical Engineering, Chongqing University, Chongqing 400044, China The First Department of Geriatric Cardiology, Chinese PLA General Hospital, Beijing, China. Department of Gynecologic Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China Department of Obstetrics and Gynecology, Affiliated Hospital of Guizhou Medical University, Guiyang, China National Research Center for Rehabilitation Technical Aids, Beijing 100176, China College of Animal Science and Technology; Northwest A&F University; Yangling 712100; China School of Physical Science and Technology ShanghaiTech University Shanghai China Monash Biomedicine Discovery Institute, Department of Microbiology, Monash University, 19 Innovation Walk, Clayton 3800, Victoria, Australia Department of Gastrointestinal Oncology, Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital and Institute, Beijing, China Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China North Sichuan Medical College , No. 234, Fujiang Street, Shunqing District , Nanchong , Sichuan Province , People’s Republic of China Department of Otorhinolaryngology–Head and Neck Surgery The First Affiliated Hospital of Sun Yat‐sen University Guangzhou China; Guangzhou Key Laboratory of Otorhinolaryngology–Head and Neck Surgery The First Affiliated Hospital of Sun Yat‐sen University Guangzhou China Beijing University of Chinese Medicine, No. 11 Beisanhuandonglu, Chaoyang District, Beijing 100029, PR China Facility for Anti-infective Drug Development and Innovation, Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Victoria, Australia Authors' Affiliations: 1Life Sciences Division, Lawrence Berkeley National Laboratories; 2Department of Statistics, University of California, Berkeley; 3Department of Dermatology, University of California, San Francisco, and 4San Francisco Dermatopathology Service, San Francisco, California; 5Emerging Technology Research Center, Samsung Advanced Institute of Technology, and 6Samsung Electronics Headquarters, Seoul, Korea; 7The Eli and Edythe L. Broad Institute of Harvard and MIT, Cambridge; 8Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts; 9Beijing Genomics Institute–Shenzhen, Shenzhen, China; 10Institute of Human Genetics, Aarhus University, Aarhus, Denmark; 11Biomedical Engineering Department, Oregon Health and Science University, Portland, Oregon; Authors' Affiliations: 1Life Sciences Division, Lawrence Berkeley National Laboratories; 2Department of Statistics, University of California, Berkeley; 3Department of Dermatology, University of California, San Francisco, and 4San Francisco Dermatopathology Service, San Francisco, California; 5Emerging Technology Research Center, Samsung Advanced Institute of Technology, and 6Samsung Electronics Headquarters, Seoul, Korea; 7The Eli and Edythe L. Broad Institute of Harvard and MIT, Cambridge; 8Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts; 9Beijing Genomics Institute–Shenzhen, Shenzhen, China; 10Institute of Human Genetics, Aarhus University, Aarhus, Denmark; 11Biomedical Engineering Department, Oregon Health and Science University, Portland, Oregon Stanford Genome Technology Center Stanford University Palo CA 93404 USA Allergy Center, Otorhinolaryngology Hospital, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China Department of Spinal Cord Injury, Institute of Orthopedics and Traumatology of Chinese PLA, General Hospital of Jinan Military Area Command, Jinan, Shandong, China Department of Rheumatology and Immunology Tianjin Fifth Central Hospital Tianjin China College of Environmental & Chemical Engineering, Yanshan University, Qinhuangdao, Peoples Republic of China. 1 Center of System Biomedical Sciences, University of Shanghai for Science and Technology, Shanghai 200093, P. R. China, 2School of Medicine, University of Missouri−Kansas City, Kansas City, MO 64108 and 3Department of Biostatistics and Bioinformatics, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA 70112, USA Department of Hematology, Peking Union Medical College Hospital School of Materials Science and Engineering, Central South University, Changsha, Hunan 410083, China; Hunan Zhengyuan Institute for Energy Storage Materials and Devices, Changsha, Hunan 410083, China Department of Pulmonary Medicine, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu 212001, P.R. China Department of Ophthalmology, Changzheng Hospital of Naval Medicine University, Shanghai, 200003, China Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, P. R. China; Department of Veterinary Medicine, College of Animal Sciences, Zhejiang University, Hangzhou 310058, China Key Laboratory of Eco-Environment-Related Polymer Materials, Ministry of Education of China, Key Laboratory of Gansu Polymer Materials, College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070, China College of Chemistry and Chemical Engineering Northwest Normal University Anning East Road 967# Lanzhou Gansu 730070 People's Republic of China Department of Surgery Jinqiu Hospital of Liaoning 110016 Shenyang People’s Republic of China College of Life Science and Technology Southwest Minzu University Chengdu Sichuan China From the Division of Cardiothoracic Surgery, Department of Surgery (C.M., Jiany Li, F.W.S.), and Cardiovascular Division (Jian Li, M.S.), Department of Medicine of Beth Israel-Deaconess Medical Center and Harvard Medical School, Boston, Mass. Institute for Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilians University of München, Munich, Germany; German Cancer Consortium (DKTK), Heidelberg, Germany; German Cancer Research Center (DKFZ), Heidelberg, Germany Department of Cardiology, the Affiliated Hospital of Hangzhou Normal University, Hangzhou, Zhejiang 310000, China Department of Orthopaedic Surgery, Orthopedic Research Institute, West China Hospital, Sichuan University, 37 Guoxue Lane, Wuhou District, Chengdu, China State Key Laboratory of Rare Earth Resource Utilization; Changchun Institute of Applied Chemistry; Chinese Academy of Sciences; Changchun 130022; China College of Environment & Chemical Engineering, Yanshan University, Qinhuangdao, P.R. China Key Laboratory of Cluster Science of Ministry of Education, Beijing Key Laboratory of Photoelectronic/Electrophotonic Conversion Materials, School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing 100081, China Deptartment of Hepatobiliary Surgery The 5th Affiliated Hospital Sun Yat‐Sen University Zhuhai China Key Laboratory of Bio-based Material Science and Technology of Ministry of Education, Northeast Forestry University, Hexing Road 26, Harbin 150040, P. R. China Department of Immunology, Hebei Medical University, Shijiazhuang, Hebei, China; Key Laboratory of Immune Mechanism and Intervention on Serious Disease in Hebei Province, Shijiazhuang, Hebei, China; Department of Pathogen Biology, Hebei Medical University, Shijiazhuang, Hebei, China Department of Prosthodontics, Peking University School, Beijing, China. Department of Gastrointestinal Surgery, Jiangxi Provincial People’s Hospital (The First Affiliated Hospital of Nanchang Medical College) , Nanchang , Jiangxi, 330006 , China Multidisciplinary Research Center, Shantou University, Shantou 515063, Guangdong, China Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China Endoscopy Center Minhang Hospital, Fudan University Shanghai China Department of Pharmacy, College of Animal Science and Technology, Henan University of Science and Technology, China Department of Dermatology, Southwest Hospital, Third Military Medical University, Chongqing, P.R. China, School of Materials Science and Engineering, Changzhou University, Changzhou 213614, Jiangsu, China; Jiangsu Collaboration Innovation Center of Photovoltaic Science and Engineering, Changzhou University, Changzhou 213164, Jiangsu, China; Jiangsu Key Laboratory of Environmentally Friendly Polymeric Materials, Changzhou University, Changzhou 213164, China Shanghai Key Laboratory of New Drug Design, School of Pharmacy, and State Key Laboratory of Bioengineering Reactor, East China University of Science and Technology, 130 Mei-long Road, Shanghai 200237, China State Key Lab of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China Biomedicine Discovery Institute Department of Microbiology Monash University Clayton Victoria Australia Department of Anesthesiology, Neuroscience Research Centre, Changzheng Hospital, Second Military Medical University, Shanghai, China; Department of Neurobiology, Key Laboratory of Molecular Neurobiology, Ministry of Education, Second Military Medical University, Shanghai, China Sports Medicine Center, Department of Orthopedic Surgery and Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu, Sichuan, China College of Mechanical and Electrical Engineering, Northeast Forestry University, Harbin 150040, China Institute of Electronic Engineering; China Academy of Engineering Physics; Mianyang; P. R. China First Department of Urology, The First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233004, P.R. China *Department of Pathology and Molecular Medicine and WuXi AppTec (Shanghai) Co., Ltd, 288 FuTe Zhong Road, Shanghai 200131, P. R. China University of Chinese Academy of Sciences, Number 19A Yuquan Road, Beijing 100049, China Institute of Occupational, Social and Environmental Medicine, University of Düsseldorf, Germany Animal Nutrition Institute Sichuan Agricultural University Chengdu 611130 P. R. China; Key Laboratory for Animal Disease‐Resistant Nutrition of the Ministry of Education of China Sichuan Agricultural University Chengdu 611130 P. R. China; Key Laboratory of Animal Disease‐Resistant Nutrition of Sichuan Province Sichuan Agricultural University Chengdu 611130 P. R. China Department of Radiology, First Affiliated Hospital of Fujian Medical University, Fuzhou, China Preclinical College, Beijing University of Chinese Medicine, Beijing 100029, China School of Pharmacy, East China University of Science & Technology, 130 Meilong Road, Shanghai 200237, People’s Republic of China Department of Urology, Gongli Hospital of the Second Military Medical University, Shanghai, PR China; Cardiovascular Institute, and Penn Muscle Institute, Department of Medicine (R.G., J.L., J. Brandimarto, Q.M., K.B.M., T.P.C., Z.A.), Perelman School of Medicine, University of Pennsylvania, Philadelphia. Department of Chemical Biology, College of Chemistry and Chemical Engineering, the Key Laboratory for Chemical Biology of Fujian Province, State Key Laboratory for Physical Chemistry of Solid Surfaces, the MOE Key Laboratory of Spectrochemical Analysis & Instrumentation, Xiamen University, Xiamen, China School of Mechatronics Engineering; Northeast Forestry University; Harbin 150040; China School of Foundations, Leadership, and Administration, Kent State University, Kent, OH, USA The NHC Key Laboratory of Geriatrics Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital/National Center of Gerontology of National Health Commission Beijing China The Key Laboratory of Hematology of Jiangxi Province, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China. E-mail: jeniferjian@gmail.com. IQIS; College of Science; Chongqing University of Posts and Telecommunications; Chongqing 400065; China Department of Urinary Surgery, Gongli Hospital, Second Military Medical University (Naval Medical University), Shanghai, China Department of Intensive Care Unit and Key Laboratory for Critical Care Medicine of the Ministry of Health, Emergency Medicine Research Institute, Tianjin First Center Hospital, Tianjin 300192, China Key Laboratory of Pesticide and Veterinary Drug Monitoring for State Market Regulation, Lanzhou Institute for Food and Drug Control, Gansu, 730050, China Department of Hematology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of China Institute of Occupational, Social, and Environmental Medicine, Centre for Health and Society, Faculty of Medicine, University of Düsseldorf, Düsseldorf, Germany; Department of Environmental Health Sciences, Fielding School of Public Health; School of Nursing, University of California, Los Angeles, USA Nanjing University of Posts and Telecommunications Prenatal Diagnostic Center, Guangzhou Women & Children Medical Center affiliated to Guangzhou Medical University, Guangzhou, Guangdong, China Clinical Laboratory Center Children's Hospital of Fudan University Shanghai China 1Graduate School of Peking Union Medical College, Beijing, China; 2The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Beijing Hospital, National Center of Gerontology, National Health Commission, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China Department of Clinical Laboratory, Chinese PLA General Hospital, Beijing 100853, China. From the Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA (A.F.M., M.J.P., S.G., J.W., P.H., J.L.); and Division of Molecular Cardiology, Department of Medicine, College of Medicine, Texas A&M Health Science Center; Scott & White; Central Texas Veterans Health Care System, Temple, TX (S.G.). Zhejiang A&F University School of mathematics and computer science, , No.666 Wusu Street,Lin’an District, 311300, Hangzhou , China Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, School of Pharmaceutical Sciences, Wuhan University, Wuhan, China Department of General Surgery, The First Affiliated Hospital of Xinxiang Medical University, Xinxiang, China. Key Laboratory of Animal Science of National Ethnic Affairs Commission of China, Southwest Minzu University, Chengdu 610041, China; Key Laboratory of Qinghai-Tibetan Plateau Animal Genetic Resource Reservation and Utilization, Ministry of Education, Southwest Minzu University, Chengdu 610041, China; Key Laboratory of Qinghai-Tibetan Plateau Animal Genetic Resource Reservation and Utilization, Sichuan Province, Southwest Minzu University, Chengdu 610041, China Department of Hepatobiliary Surgery, Hospital Affiliated to Chengde Medical University, Chengde, Hebei, China; Department of Hepatobiliary Surgery, You’an Hospital Affiliated to Capital Medical University, Beijing, China Key Laboratory for Animal Disease-Resistant Nutrition of the Ministry of Education of China, and Animal Nutrition Institute, Sichuan Agricultural University, Wenjiang, Chengdu 611130, People’s Republic of China Laboratory of Carcinogenesis & Translational Research for the Ministry of National Education, Department of GI Oncology, Peking University School of Oncology, Beijing Cancer Hospital & Institute, Beijing, 100142 China Key Laboratory for Animal Disease Resistance Nutrition of the Ministry of Education, Animal Nutrition Institute, Sichuan Agricultural University, Chengdu 611130, China Department of Urology, Tianjin People’s Hospital, Tianjin, China Third Military Medical University, PR China State Key Laboratory of Electronic Thin Films and Integrated Devices, and School of Optoelectronic Science and Engineering, University of Electronic Science and Technology of China (UESTC), Chengdu, Sichuan 610054, China Center for NeuroGenetics, College of Medicine, University of Florida, Gainesville, FL 32610, USA; Department of Molecular Genetics and Microbiology, College of Medicine, University of Florida, Gainesville, FL 32610, USA; Genetics Institute, University of Florida, Gainesville, FL 32610, USA Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science & Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou 215123, China Department of Orthopaedics, Orthopedic Research Institute, West China Hospital Sichuan University Chengdu People's Republic of China Department of Cardiology, The Affiliated Hospital of Qingdao University, Qingdao 266003, China College of Food and Biological Engineering Jimei University Xiamen P.R. China Triticeae Research Institute, Sichuan Agricultural University, Chengdu, Sichuan 611130, P.R. China Shanghai Key Laboratory of Atmospheric Particle Pollution and Prevention (LAP3), Department of Environmental Science and Engineering, Fudan University, Shanghai, People’s Republic of China; Junyue Energy and Technology (Shanghai) Co, Ltd, Shanghai, People’s Republic of China Department of Veterinary Medicine, College of Animal Sciences, Zhejiang University, Hangzhou, Zhejiang Province 310058, China College of Animal & Veterinary Sciences, Southwest Minzu University, Chendu 610041, China; Key Laboratory of Qinghai-Tibetan Plateau Animal Genetic Resource Reservation and Utilization, Southwest Minzu University, Ministry of Education, Chengdu 610041, China Infection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Microbiology, Monash University, Clayton, Victoria 3800, Australia Facility for Anti-Infective Drug Development and Innovation, Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Melbourne, Australia Department of Cardiology, South Campus, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 201112, China; Department of Internal Medicine, Shanghai Sixth People’s Hospital East Campus, Shanghai University of Medicine & Health Sciences, Shanghai 201306, China Centre to Impact Antimicrobial Resistance, Monash University, Clayton 3800, VIC, Australia; Monash Biomedicine Discovery Institute, Monash University, Clayton 3800, VIC, Australia Department of Pediatric Hematology, Fujian Medical University Union Hospital, Fujian Institute of Hematology, Fujian Provincial Key Laboratory of Hematology, Fuzhou 350001, Fujian Province, China,E-mail: 1354113723@qq.com. Domestic Discovery Service Unit, WuXi AppTec, 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131, China Infectious Diseases Department, Shandong University Qilu Children’s Hospital, Jinan, China Key Laboratory of Hematology,The Second Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province,China. E-mail:jeniferjian@gmail.com. Department of Gastrointestinal Oncology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Peking University Cancer Hospital & Institute, Hai-Dian District, Beijing, China Institute of Hepatopancreatobiliary Surgery, Southwest Hospital, Third Military Medical University, Chongqing, PR China Halliburton Energy Services, 3000 North Sam Houston Parkway East, Houston, Texas 77032, United States School of Public Health and Tropical Medicine, Tulane University , New Orleans, Louisiana, USA Department of Endocrinology, Liaocheng City People's Hospital, Liaocheng, Shandong 252000, P.R. China Nanjing Jiangning District Hospital of TCM, Nanjing, China Peking University State Key Laboratory of Power Transmission Equipment & System Security and New Technology, Chongqing University, Chongqing 400044, P. R. China School of Pharmacy, Changzhou University, Changzhou 213164, China; Jiangsu Key Laboratory of Advanced Catalytic Materials and Technology, Analysis and Testing Center, NERC Biomass of Changzhou University, Changzhou 213164, China Key Laboratory of Qinghai-Tibetan Plateau Animal Genetic Resource Reservation and Exploitation of Ministry of Education, College of Animal & Veterinary Sciences, Southwest Minzu University, Chengdu 610041, China; Key Laboratory for Animal Science of National Ethnic Affairs Commission, College of Animal & Veterinary Sciences, Southwest Minzu University, Chengdu 610041, China Department of Obstetrics and Gynecology, The First Hospital Affiliated to Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang 150040, China. Department of Otolaryngology, Chengde Central Hospital Taikai Disconnector Co., Ltd., Taian 271000, China School of Information Engineering, Zhejiang A & F University, Zhejiang, Lin'an 311300, China Department of Chemistry The Scripps Research Institute 130 Scripps Way Jupiter FL 33458 USA State Key Laboratory on Lead Compound Research WuXi AppTech Co., Ltd. Shanghai 200131 China Department of Gastrointestinal Oncology Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing) Peking University Cancer Hospital & Institute Beijing 100142 P. R. China University of Chinese Academy of Sciences Department of Joint Surgery, Affiliated Hospital of Binzhou Medical University, Binzhou, Shandong 256603, P.R. China East China University of Science and Technology, Shanghai, China Broadband Wireless Communication and Sensor Network Technology; National Engineering Research Center Animal Disease-Resistance Nutrition, Ministry of Education, Ministry of Agriculture and Rural Affairs, Key Laboratory of Sichuan Province, Animal Nutrition Institute, Sichuan Agricultural University, Chengdu 611130, Sichuan, P. R. China Infection Program and Department of Microbiology, Biomedicine Discovery Institute, Monash University Clayton, VIC 3800, Australia School of Basic Medical Sciences, Nanchang University, Nanchang, 330031 Jiangxi, China;; Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, KY 40536; Key Laboratory of Study and Discovery of Small Targeted Molecules of Hunan Province School of Medicine Hunan Normal University Changsha China Department of Ultrasound, Shenzhen People’s Hospital, The Second Clinical Medical College of Jinan University, Shenzhen, China; Shenzhen Medical Ultrasound Engineering Center, Shenzhen People’s Hospital, The Second Clinical Medical College of Jinan University, Shenzhen, China College of Computer Science and Technology, Qingdao University, Qingdao, China Cancer Center Daping Hospital & Institute of Research Institute of Field Surgery Third Military Medical University Chongqing China Department of Neurosurgery, Xiangya Hospital of Central South University, Changsha, Hunan 410008, China Key Laboratory of Bio-Based Material Science and Technology, Ministry of Education, Northeast Forestry University, Harbin 150040, China Key Laboratory of Hematology , The Second Affiliated Hospital of Nanchang University,Nanchang 330006,Jiangxi Province,China,E-mail:ndefy03048@ncu.edu.cn. Gastroenterology Department of Orthopaedic Surgery, West China Hospital, Sichuan University, Chengdu, China Department of Hepatobiliary Surgery, The First Hospital of Changsha, Changsha, Hunan 410005, P.R. China Key Lab of Organic Optoelectronic and Molecular Engineering, Department of Chemistry, Tsinghua University, Beijing 100084, People’s Republic of China Family Planning Department Beijing Obstetrics and Gynecology Hospital Capital Medical University Beijing China Key Laboratory for Animal Disease Resistance Nutrition of the Ministry of Education, Animal Nutrition Institute, Sichuan Agricultural University, Chengdu, Sichuan 611130, People’s Republic of China Key Laboratory of Function‐oriented Porous Materials of Henan Province College of Chemistry and Chemical Engineering Luoyang Normal University Luoyang Henan 471934 P. R. China School of Pharmacy, East China University of Science and Technology, Shanghai 200237, P. R. China Medical Research Center of Qianfoshan Hospital, Shandong University, Jinan, Shandong 250014, China. chang-xt@163.com. Chinese PLA General Hospital, China BGI‐Shenzhen Shenzhen China School of Materials Science and Engineering Center for Supramolecular Chemistry and Catalysis and Department of Chemistry Shanghai University Shanghai 200444 P. R. China School of Management, Xi'an Jiaotong University, Xi'an, Shaanxi, People's Republic of China Second Affiliated Hospital of Guangzhou University of TCM, Guangzhou. Department of Pathology, Peking University Shenzhen Hospital; State Key Laboratory of Chemical Oncogenomics, Peking University Shenzhen Graduate School Department of Gastrointestinal Oncology, Key Laboratory of Carcinogenesis & Translational Research (Ministry of Education), Peking University Cancer Hospital & Institute, Beijing, 100142, China Beijing Key Laboratory of Flavor Chemistry Beijing Technology and Business University Beijing China g Key Laboratory for Green Chemical Technology of Ministry of Education, School of Chemical Engineering and Technology, Tianjin University, 92 Weijin Road, Nankai District, Tianjin 300072, P. R. China Department of Thoracic Surgery, West China Hospital Sichuan University No. 37, Guoxue Alley 610041 Chengdu Sichuan China; Western China Collaborative Innovation Center for Early Diagnosis and Multidisciplinary Therapy of Lung Cancer Sichuan University 610041 Chengdu China Department of Pharmacy, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou, China.; Guangzhou Key Laboratory of Rational Drug Use for the Elderly with Chronic Disease, Guangzhou, China. Department of Otorhinolaryngology Head and Neck Surgery The First Affiliated Hospital of Sun Yat‐sen University Guangzhou China; Guangzhou Key Laboratory of Otorhinolaryngology Head and Neck Surgery the First Affiliated Hospital of Sun Yat‐sen University Guangzhou China College of Internet of Things Engineering, Hohai University, Changzhou 213001, China; Science and Technology on Underwater Vehicle Technology Laboratory, Harbin Engineering University, Harbin 150001, China Laboratory of Extracorporeal Life Support, Lanzhou University Second Hospital, Lanzhou University, Lanzhou, China Department of Orthopaedics, the Second Municipal People's Hospital, Affiliated to Guangzhou Medical College, Guangzhou 510150, China. College of Pharmaceutical Sciences, Gannan Medical University, Ganzhou, China University of Pennsylvania Cardiovascular Institute, Department of Chemistry, Shanghai University, Shanghai 200444, P. R. China. Shanghai Institute of Applied Physics; Chinese Academy of Sciences; Shanghai 201203; P. R. China School of Materials Science and Engineering Huazhong University of Science and Technology Wuhan Hubei 430074 China Center of Molecular and Translational Medicine, Georgia State University, Atlanta, Georgia, USA Hematology Department, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100730, China. Peking University First Hospital, Department of Thoracic Surgery Peking University Health Science Center Beijing China Department of Endocrinology and Metabolism, First People’s Hospital of Xinxiang City, Xinxiang, Henan 453000, China College of Animal Science and Technology, Guangxi University, Nanning 530005, China. Department of General Surgery, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, P.R. China Karolinska Institutet, Department of Molecular Medicine and Surgery, Karolinska University Hospital, Solna, Stockholm, Sweden; Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Florida P.O. Box 100214, Gainesville, FL, 32610 USA. State Key Laboratory of Microbial Technology, Marine Biotechnology Research Center, Shandong University, Qingdao 266237, PR China Key Laboratory for Animal Disease-Resistance Nutrition of the Ministry of Agriculture, Animal Nutrition Institute, Sichuan Agricultural University, Chengdu, China Department of Orthopaedic Surgery, West China Hospital, Sichuan University Department of Family Planning, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China. Email: lijian02@hotmail.com. Shanghai East Clinical Medical School, Nanjing Medical University Shanghai 200000, China. Department of Anesthesiology, The Affiliated Huaian No. 1 People's Hospital of Nanjing Medical University Huai'an 223001, Jiangsu, China. Wuhan Research Institute of Materials Protection, Wuhan 430030, Hubei, China Department of Thoracic Surgery, Cancer Hospital (Institute), Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China. lijian89@hotmail.com Department of Oncology, Shanghai Fourth People’s Hospital, Tongji University School of Medicine, Shanghai, China School of Pharmaceutical Science and Technology, Key Laboratory for Modern Drug Delivery & High-Efficiency, Tianjin University, Tianjin, 300072 P. R. China Biomedicine Discovery Institute Monash University Clayton Victoria Australia Department of Ultrasound Sun Yat‐sen University Cancer Center; State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine Guangzhou China *The Wistar Institute, and Endoscopy Research Institute, Endoscopy Center, Zhongshan Hospital, Fudan University, Shanghai 200032, P.R. China Department of Gastrointestinal Surgery, Jiangxi Provincial People’s Hospital, Nanchang, Jiangxi Province, China Department of Otolaryngology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China; Guangzhou Key Laboratory of Otorhinolaryngology, Guangzhou, China State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, Fujian, China Development of Gastroenterology, The People’s Hospital of Nanchuan, Chongqing 408400, China National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Beijing 100101, China, Graduate School of the Chinese Academy of Sciences, Beijing 100049, China, and Department of Biochemistry and Molecular Biology and Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria 3010, Australia Department of Geriatric Endocrinology, Nanlou Division, Chinese PLA General Hospital, National Clinical Research Center for Geriatric Diseases, Beijing, China Department of Orthopedics (Minimally Invasive Spine Surgery Branch), Beijing Haidian Hospital (Haidian Section of Peking University Third Hospital), Hai-Dian District, Beijing, China Second Clinical Medical College, Lanzhou University, Lanzhou, China School of Basic Medical Sciences School of Medicine Chengdu China College of Ocean Food and Bioengineering, Jimei University, Xiamen, 361021, P.R. China Department of Radiation Oncology, Guangzhou Medical University, Guangzhou, Guangdong, China State Key Laboratory of Biocontrol, Guangdong Provincial Key Laboratory of Plant Resources, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, P.R. China Facility for Anti-infective Drug Development and Innovation, Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia Department of Hematology, Peking Union Medical College Hospital, Beijing 100730, China. E-mail: pumch.li.jian@gmail.com. Green Catalysis Center, College of Chemistry, Zhengzhou University, Zhengzhou 450001, China; College of Ecology and Environment, Zhengzhou University, Zhengzhou 450001, China Department of Plastic and Cosmetic Surgery, Nanfang Hospital Southern Medical University Guangzhou P. R. China Department of Gastrointestinal Oncology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital & Institute, Beijing, People's Republic of China Department of Chemistry, University of Southern California, Los Angeles, California 90089, Beckman Institute, California Institute of Technology, Pasadena, California 91106, Department of Chemical Physics, Lund University, Lund, Sweden, and Department of Chemistry, University of Illinois, Urbana, Illinois 61801 State Key Laboratory of Genetic Engineering, Ministry of Education Key Laboratory for Biodiversity Science and Ecological Engineering, Ministry of Education Key Laboratory of Contemporary Anthropology, School of Life Science, Fudan University, Shanghai 200438, China Key Laboratory of Pesticide and Veterinary Drug Monitoring for State Market Regulation, China; Lanzhou Institute for Food and Drug Control, Gansu Province, China State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources College of Chemistry and Pharmacy Guangxi Normal University Guilin P. R. China Orthopedics The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, China Department of Orthopaedics Surgery Orthopaedic Research Institute, West China Hospital, Sichuan University Chengdu China Key Laboratory of Pesticide and Veterinary Drug Monitoring for State Market Regulation/Lanzhou Institute for Food and Drug Control, Gansu, P. R. China Department of Glaucoma and Cataract, Aier Eye Hospital of Shaoyang, Shaoyang, Hunan Province, China Key Laboratory of Organic Synthesis of Jiangsu Province; College of Chemistry; Chemical Engineering and Materials Science & Collaborative Innovation Center of Suzhou Nano Science and Technology; Soochow University; Suzhou Guangdong Key Laboratory of Chiral Molecule and Drug Discovery; School of Pharmaceutical Sciences; Sun Yat-sen University; Guangzhou 510006; P. R. China Zhengzhou Traditional Chinese Medicine Traumatology Hospital, Zhengzhou, Henan 450016, China Department of Orthopedics, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China 1 Division of Cardiology, Department of Medicine, the Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA Department of Respiratory, Department of Infectious Diseases, School of Basic Medical Sciences, Renmin Hospital Hubei University of Medicine Shiyan China Hubei Province Huangshi Puren Hospital Cardiovascular Medicine, 435002, China Department of Pharmaceutics, Guangdong College of Pharmacy, Guangzhou 510006, China. Peking University Fifth School of Clinical Medicine, Beijing, China; The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Beijing Hospital, National Center of Gerontology, National Health Commission, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China Key Laboratory of Bio-Based Materials Science and Technology of Ministry of Education, Northeast Forestry University, No. 26 Hexing Road, Xiangfang District, Harbin 150040, China Centre for Pharmaceutical Research, University of South Australia, Adelaide, South Australia 5000 Key Laboratory of Photochemical Conversion and Optoelectronic Materials and CityU‐CAS Joint Laboratory of Functional Materials and Devices Technical Institute of Physics and Chemistry Chinese Academy of Sciences Beijing 100190 P. R. China; School of Future Technology University of Chinese Academy of Sciences Beijing 100049 China Key Laboratory of Functional Polymer Materials of Ministry of Education and College of Chemistry, Nankai University, Tianjin 300071, China State Key Laboratory of Rare Earth Resource Utilization; Changchun Institute of Applied Chemistry; Chinese Academy of Sciences; 5625 Renmin Street Changchun 130022 P. R. China; University of Chinese Academy of Sciences; Beijing 100049 P. R. China Jiangsu Key Laboratory of Advanced Catalytic Materials & Technology, and School of Pharmaceutical Engineering & Life Science; Changzhou University; Changzhou 213164; P. R. China Drug Delivery, Disposition and Dynamics; Monash Institute of Pharmaceutical Science; Australia Department of Chemistry and Biochemistry, University of California, Los Angeles, California 90095, and the Department of Chemistry, University of Southern California, Los Angeles, California 90089 Department of Cardiology, The Affiliated Hospital of Qingdao University , No. 1677 Wutaishan Road , Qingdao , 266000 , China School of Environmental Science and Engineering, State Key Laboratory of Separation Membranes and Membrane Processes, Tiangong University, Tianjin 300387, China Department of Gastroenterology Henan Provincial People's Hospital Zhengzhou University Zhengzhou China; Department of Pathology and MCW Cancer Center Medical College of Wisconsin Milwaukee WI USA Department of Cardiology The Affiliated Hospital of Qingdao University Qingdao China Department of Gastrointestinal Oncology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing) Peking University Cancer Hospital & Institute Beijing China NHC Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, and Center for AIDS Research, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, PR China Department of Ultrasound, The First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine, Nanning, Guangxi, China Animal Nutrition Institute, Sichuan Agricultural University, Key laboratory of Animal Disease‐resistant Nutrition, Ministry of Education Ministry of Agriculture and Rural Affairs Chengdu Sichuan 611130 P. R. China Department of Oral and Maxillofacial Surgery, School of Stomatology, Wuhan University, China. Department of Preventive Dentistry, Central Laboratory, School of Stomatology, China Medical University. Shenyang 110002, Liaoning Province, China.E-mail:794239430@qq.com. Department of Gastrointestinal Oncology, Peking University Cancer Hospital, Beijing 100142, China. oncogene@163.com. School of Biotechnology and Health Sciences; Wuyi University; Jiangmen; China Department of Radiology, The First Hospital of China Medical University, Shenyang, Liaoning, PR China; Department of Psychology,; Center for Neural Science, New York University, New York, NY 10003; and Institute of Occupational, Social and Environmental Medicine, Center for Health and Society, Faculty of Medicine, University of Düsseldorf, Germany State Key Laboratory of Supramolecular Structure and Materials College of Chemistry Jilin University Changchun 130012 P. R. China Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangdong-Hong Kong Joint Laboratory for RNA Medicine, Medical Research Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China Soochow University 1 Center for Soft Condensed Matter Physics and Interdisciplinary Research, College of Physics, Optoelectronics and Energy, , Suzhou 215006, China; Nanjing Normal University 3 Department of Physics, , Nanjing 210023, China Department of Thoracic and Cardiovascular Surgery, Nanjing First Hospital, Nanjing Medical University, P.R. China Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry & University of Chinese Academy of Sciences, Chinese Academy of Sciences, Beijing 100190, People’s Republic of China Hepatic Surgery Center, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan China Department of Urology, Tianjin Union Medical Center, Tianjin, China. Department of Orthopaedics Jiangxi Provincial Children's Hospital Nanchang City Jiangxi Province China Key Laboratory of Animal Diseases Diagnostic and Immunology, MOE International Joint Collaborative Research Laboratory for Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University , Nanjing, Jiangsu, China Key laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Gastrointestinal Oncology Peking University Cancer Hospital and Institute Beijing China Peking Union Medical College Hospital (PUMCH), Beijing, China Department of Gastrointestinal Oncology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Peking University Cancer Hospital and Institute, Beijing 100142, China. Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, China; Institute of Hepatobiliary and Pancreatic Diseases, Zhengzhou University, Zhengzhou, China Dermatology Department, Southwest Hospital Third Military Medical University Chongqing China Key Laboratory of Beijing on Regional Air Pollution Control, College of Environmental and Energy Engineering, Beijing University of Technology, Beijing, People’s Republic of China Shaanxi Key Laboratory of Green Preparation and Functionalization for Inorganic Materials, Shaanxi University of Science and Technology School of Materials Science and Engineering Xi'an People's Republic of China Affi liated Hospital of Zunyi Medical College, Department of Thoracic and Cardiovascular Surgery, Zunyi, Guizhou School of Kinesiology, Shanghai University of Sport, Shanghai city, China Key Laboratory for Animal Disease-Resistant Nutrition of China Ministry of Education, Ministry of Agriculture and Rural Affairs, Institute of Animal Nutrition, Sichuan Agricultural University, Chengdu 611130, China State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing 100029, China Prenatal Diagnostic Center, Guangzhou Women and Children’s Medical Center affiliated to Guangzhou Medical University, Guangzhou, People’s Republic of China Department of Orthopedic Surgery, West China Hospital, Sichuan University, Chengdu, China.; Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu, China. Peking University Fifth School of Clinical Medicine Beijing China; Key Laboratory of Geriatrics Beijing Hospital and Beijing Institute of Geriatrics Ministry of Health China Department of Orthopedics, West China Hospital, Chengdu Sichuan, 610041, P.R.China.hxlijian.china@163.com. Monash Biomedicine Discovery Institute, Department of Microbiology, Monash University, Clayton, VIC, Australia Engineering Research Center of Advanced Wooden Materials, Ministry of Education, Hexing Road 26, Harbin 150040, P. R. China; Key Laboratory of Bio-based Material Science & Technology (Northeast Forestry University), Ministry of Education, Hexing Road 26, Harbin 150040, P. R. China Department of Radiology Tianjin Hospital, Tianjin University Tianjin China C.R.T.S. Besançon, France Monash Biomedicine Discovery Institute; Monash University; Clayton; Australia Key Laboratory of Systematic Mycology & Lichenology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100190, People’s Republic of China, and Graduate School of Chinese Academy of Sciences, Beijing 100039, People’s Republic of China Key Laboratory of Photochemical Conversion and Optoelectronic Materials; Technical Institute of Physics and Chemistry; Chinese Academy of Sciences; Beijing 100190; P. R. China Shanghai Key Laboratory of New Drug Design; School of Pharmacy; East China University of Science and Technology; 130 Mei Long Road Shanghai 200237 P. R. China Key Laboratory of Sustainable Development of Marine Fisheries, Ministry of Agriculture, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, 266071 Qingdao, PR China Prenatal Diagnostic Center, Guangzhou Women and Children’s Medical Center, Guangzhou, People’s Republic of China School of Pharmacy, Fudan University, Shanghai, 201203, P. R. China, and Key Laboratory for Special Functional Materials of the Ministry of Education, Henan University, Kaifeng, 475004, P. R. China Department of Anesthesiology, The First Affiliated Hospital of Wenzhou Medical University, Nanbaixiang Ouhai District of Wenzhou, Zhejiang, P. R. China, 325000. School of Chemistry and Chemical Engineering, Shaanxi Key Laboratory of Low Metamorphic Coal Clean Utilization, Yulin University, Yulin 719000, People’s Republic of China Key Laboratory of Hematology, The Second Affiliated Hospital of Nanchang University.E-mail: ndefy03048@ncu.edu.cn. Analysis Center Guangdong Medical University Zhanjiang 524023 China Peoples’ Hospital of Pubei, Qinzhou 535300, China Department of Hematology, Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China Department of biochemistry, Institute of Basic Medical Sciences, Hubei University of Medicine Shiyan China School of Chemical Engineering, Nanjing University of Science and Technology, Nanjing 210094, P. R.China Key Laboratory of Bio-based Materials Science and Technology of Ministry of Education, Northeast Forestry University, 26th Hexing Road, Xiangfang District, Harbin 150040, P. R. China College of Animal Science and Technology, Jilin Agricultural University, Changchun, China. Department of Orthopedics, Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu, China Center for Cardiovascular Research/Institute of Pharmacology, Charité, Berlin, Germany, Department of Infectious Diseases, The First Affiliated Hospital of Jinan University, Guangzhou, China Bioinformatics Research Center; Department of Genetics, North Carolina State University, Raleigh, North Carolina 27695 Prenatal Diagnostic Center, Guangzhou Maternal & Neonatal Hospital Guangzhou Women and Children's Medical Center Guangzhou Guangdong China School for Engineering of Matter, Transport and Energy, Arizona State University, Temple, Arizona 85284, United States Department of Neurology, Beijing Chaoyang Hospital (Xi District), Capital Medical University, Beijing, China (mainland). Tianjin Key Laboratory of Ionic‐Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University, Tianjin, China Clinical Research Center, Ruijin Hospital, and Department of Orthopedics, Sports Medicine Center, West China Hospital, Sichuan University, Chengdu, China. School of Forensic Medicine, Shanxi Medical University , Jinzhong, China Department of Hematology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China Department of Radiology, The First Affiliated Hospital, Nanchang University; Neuroimaging Lab, Jiangxi Province Medical Imaging Research Institute Institute of Occupational, Social and Environmental Medicine, Centre for Health and Society, Faculty of Medicine, Heinrich-Heine-University of Düsseldorf, Düsseldorf, Germany; Department of Cardiology, Wuxi People's Hospital Affiliated to Nanjing Medical University, Wuxi, Jiangsu 214023, P.R. China Department of Obstetrics and Gynecology, First Affiliated Hospital, Heilongjiang University of Chinese Medicine, 26 Heping Road, Harbin, China Department of Gastrointestinal Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, People's Republic of China. jamle1981@sina.com Monash Biomedicine Discovery Institute, Department of Microbiology, Monash University, Clayton, Victoria, Australia Beijing Laboratory for Food Quality and Safety Beijing Technology and Business University Beijing China School of Environmental Science and Engineering, Tianjin University, Tianjin 300350, China State Key Laboratory of Analytical Chemistry for Life Science School of Chemistry and Chemical Engineering Nanjing University Nanjing 210023 China Key laboratory of Bio‐based Material Science and Technology of Ministry of Education Northeast Forestry University Hexing Road 26 Harbin 150040 P. R. China Shandong Key Laboratory of Eco-Environmental Science for the Yellow River Delta, Shandong Provincial Engineering and Technology Research Center for Wild Plant Resources Development and Application of Yellow River Delta, College of Biological and Environmental Engineering, Binzhou University, Binzhou 256603, China School of Electrical Engineering and State Key Laboratory of Power Transmission Equipment & System Security and New Technology, Chongqing University, 400044 Chongqing, China Institute of Occupational and Social Medicine, Center for Health and Society, Faculty of Medicine University of Düsseldorf Düsseldorf Germany The Reproductive Medicine Center, Peking University Shenzhen Hospital Shenzhen Peking University‐The Hong Kong University of Science and Technology Medical Center Shenzhen China Prenatal Diagnostic Center, Guangzhou Women and Children’s Medical Center, Southern Medical University, Guangzhou, Guangdong Province, People’s Republic of China School of Public Health and Tropical Medicine, Tulane University, New Orleans, USA. Engineering Research Center of Sichuan-Tibet Traditional Medicinal Plant, Chengdu University , China; School of Basic Medical Sciences, Chengdu University , China Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1095, Jiefang Avenue, Wuhan 430030, Hubei, China School of Information Engineering; Key Laboratory of Forestry Intelligent Monitoring and Information Technology of Zhejiang Province; Zhejiang A & F University; Linan, China Cancer Center, Institute of Surgical Research, Daping Hospital The Military Medical University Chongqing China Department of Prenatal Diagnostic Center, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou 510623, China; Department of Obstetrics, Qingdao Central Hospital, Qingdao, Shandong 266042, P.R. China Department of Medical Image, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, Shandong 264000, P.R. China Department of Radiotherapy Tumor Hospital of Guangzhou Medical University Guangzhou Guangdong China Beijing Institute of Veterinary Drugs Control, Beijing, P. R. China 3 Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia Department of Clinical Medicine, Medical College of Hunan Normal University, Changsha 410006, China. Drug Discovery, Johnson & Johnson Pharmaceutical Research & Development, Spring House, Pennsylvania 19477-0776, and Drug Discovery, Johnson & Johnson Pharmaceutical Research & Development, Raritan, New Jersey 08869-0602 Clinical Research Center Ruijin Hospital Shanghai Jiaotong University School of Medicine Shanghai China Department of Blood Transfusion, The Third Xiangya Hospital, Central South University, Changsha, 410013, Hunan, China University of Chinese Academy of Sciences, Beijing, 100049, China; Shenzhen Engineering Research Center for Medical Bioactive Materials, Center for Translational Medicine Research & Development, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong, 518055, China From the Division of Cardiothoracic Surgery, Department of Surgery, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA. Animal Disease-Resistance Nutrition, Ministry of Education, Ministry of Agriculture and Rural Affairs, Key Laboratory of Sichuan Province, Animal Nutrition Institute, Sichuan Agricultural University , Chengdu 611130, Sichuan , P. R. China Department of Hematology, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China. E-mail: jeniferjian@gmail.com. The First Department of General Surgery, Affiliated Hospital of Chengde Medical University, Chengde 067000, P.R. China Department of Microbiology, Infection and Immunity Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia School of Pharmaceutical Engineering & Life Science, Changzhou University, Changzhou 213164, P. R. China School of Physical Science and Technology, ShanghaiTech University, Shanghai, China. lijian@shanghaitech.edu.cn. 1 Bina Technologies, Roche Sequencing, Redwood City, CA 94065, USA, Department of Cardiology, The Affiliated Hospital of Qingdao University, Jiangsu Road 16, 266000 Qingdao, Shandong, China Department of Urology The First Affiliated Hospital of Bengbu Medical College Bengbu Anhui China Key Laboratory of Urban Environment and Health, Ningbo Observation and Research Station, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen 361021, China; Zhejiang Key Laboratory of Urban Environmental Processes and Pollution Control, CAS Haixi Industrial Technology Innovation Center in Beilun, Ningbo 315830, China Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester and Manchester University NHS Foundation Trust, Manchester, U.K. Department of Urology, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian 361003, P.R. China Material Science and Engineering College, Northeast Forestry University, Harbin 150040, P. R. China School of Electronics and Information Technology; Sun Yat-sen University; Guangzhou 51000; China Monash Biomedicine Discovery Institute, Department of Microbiology, Monash University, Melbourne, Victoria, Australia Department of Interventional Radiology, The Affiliated Hospital of Qingdao University , Qingdao, China State Key Laboratory of Power Transmission Equipment and System Security and New Technology School of Electrical Engineering Chongqing University Chongqing 401331 China Department of Human Parasitology, College of Basic Medicine; Department of Infectious Diseases, Renmin Hospital, Hubei University of Medicine, Shiyan, People’s Republic of China State Key Laboratory of Membrane Biology, School of Life Sciences, Tsinghua University, Beijing, China Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (Ministry of Education), School of Pharmaceutical Sciences, Wuhan University, Wuhan, 430071, China Facility for Anti-Infective Drug Development and Innovation, Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia Key laboratory of Bio-based Material Science and Technology Ministry of Education Northeast Forestry University Harbin 150040 P. R. China CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203, China; University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing 100049, China Tasly Biopharmaceuticals Co., Ltd., Shanghai, China The Scripps Research Institute, Department of Chemistry, 130 Scripps Way, Jupiter, Florida 33458 United States Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305-5307 Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China Shanghai Institute of Materia Medica, Chinese Academy of Sciences, No. 501 Haike Road & No. 555 Zuchongzhi Road, Shanghai, 201203, PR China Department of Ultrasound, Shenzhen People’s Hospital, The Second Affiliated Hospital of Medical College of Jinan University, Shenzhen, China Department of Surgery, University of Tennessee, Memphis, TN 38163 Department of Anatomy, Chengdu Medical College, Chengdu, Sichuan 610500, China School of Biotechnology and Health Sciences, Wuyi University, Jiangmen, Guangdong Province 529090, China Key Laboratory of Bio-Based Material Science & Technology of Ministry of Education, Northeast Forestry University, Harbin 150040, China Department of Pharmacy, State Key Laboratory of Biotherapy West China School of Pharmacy, Sichuan University Chengdu Sichuan, 610041 China Department of Biomedical Engineering, City University of Hong Kong, Hong Kong 999077, China; Hong Kong Center for Cerebra-Cardiovascular Health Engineering, Hong Kong Science Park, Hong Kong 999077, China Institute of Animal Nutrition and Ministry of Education of ChinaSichuan Agricultural UniversityChengduChina Department of Neurosurgery Xiangya Hospital Central South University Changsha China Department of Joint and Hand Surgery, The First People’s Hospital of Huaihua (Jishou University of the Fourth Affiliated Hospital), Huaihua, Hunan, 418000, China Institute of Occupational, Social and Environmental Medicine, Centre for Health and Society, Faculty of Medicine University of Düsseldorf Düsseldorf Germany Department of Dermatology, Huashan Hospital of Fudan University, Shanghai, China; Department of Biomedical Engineering City University of Hong Kong Kowloon Tong Hong Kong; Hong Kong Center for Cerebra‐Cardiovascular Health Engineering Hong Kong Science Park New Territories Hong Kong Center for Medical Mycology; Department of Dermatology, University Hospitals of Cleveland and Case Western Reserve University, Cleveland, Ohio 44106 Infection Program and Department of Microbiology , Biomedicine Discovery Institute, Monash University , Melbourne , Australia Department of Gastrointestinal Oncology, Peking University Cancer Hospital and Institute, Beijing 100142, China. oncogene@163.com. Stroke Center, Rizhao Central Hospital, Rizhao, Shandong, 276800, China Shanghai 10th People's Hospital, Tongji University School of Medicine, Shanghai 200072, P. R. China, Department of Orthopedics, The 4th Affiliated Hospital, China Medical University, Shenyang, 110032, P. R. China, Department of Nutrition, University of North Carolina at Greensboro, North Carolina Research Campus, Kannapolis NC 28081, Department of Orthopedics, The Changhai Hospital of Second Military Medical University, Shanghai 200433, P. R. China, School of Pharmacy, and Ministry of Education Key... Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus), Parkville, Victoria, Australia School of Public Health and Beijing Key Laboratory of Environmental Toxicology Capital Medical University Beijing China Key Laboratory of Vegetation Restoration and Management of Degraded Ecosystems & CAS Engineering Laboratory for Vegetation Ecosystem Restoration on Islands and Coastal Zones, South China Botanical Garden, Chinese Academy of Sciences , Guangzhou 510650, China; Key Laboratory of Urban Environment and Health, Ningbo Observation and Research Station, Institute of Urban Environment, Chinese Academy of Sciences , Xiamen 361021, China; Zhejiang Key Laboratory of Urban Environmental Processes and Pollution Control, CAS Haixi Industrial Technology Innovation Center in Beilun , Ningbo 315830, China Key Laboratory for Animal Disease Resistance Nutrition of the Ministry of Education; Animal Nutrition Institute; Sichuan Agricultural University; Chengdu 611130; People's Republic of China Department of Reproductive Medicine, Peking University Shenzhen Hospital , Shenzhen , China UNILAB, State Key Lab of Chemical Engineering, School of Chemical Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, P. R. China Facility for Anti-infective Drug Development and Innovation Drug Delivery, Disposition and Dynamics Monash Institute of Pharmaceutical Sciences Monash University 381 Royal Parade Parkville, Victoria 3052, Australia PET Center of Xiangya Hospital, Central South University, Changsha, Hunan, China Key Laboratory of Photochemical Conversion and Optoelectronic Materials Technical Institute of Physics and Chemistry The Chinese Academy of Sciences Beijing 100190 P. R. China; School of Future Technologies University of Chinese Academy of Sciences Beijing 100190 P. R. China Department of Cardiology, Huashan Hospital, Fudan University, Shanghai, China (Y.C., H.Z., Y.Z., J.L., W.S., X.L., H.S., W.G.). Jian Li, Kent State University State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry, Chinese Academy of Sciences Changchun 130022 P. R. China; University of Science and Technology of China Hefei 230026 P. R. China School of Life Sciences, Sun Yat-sen University, Guangzhou, 510275, China. Biomedicine Discovery Institute, Department of Microbiology, Monash University, Clayton, Australia Guangzhou University of Chinese Medicine, Guangzhou, China Preclinical College, Beijing University of Chinese Medicine, Beijing, China Institute for Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilians-Universität München, Munich, Germany; German Cancer Consortium (DKTK), Heidelberg, Germany; German Cancer Research Center (DKFZ), Heidelberg, Germany Department of Cardiology, the First Affiliated Hospital of China Medical University, People's Republic of China Department of Pediatrics and Department of Cancer Center, Daping Hospital Army Medical University Chongqing China Department of Safety Engineering, University of Wuppertal, Wuppertal, Germany, lijian1974@hotmail.com, School of Public Health, Fudan University, Shanghai, China, School of Public Health, Kunming Medical University, Kunming, China Department of Human Parasitology, School of Basic Medical Sciences, Hubei University of Medicine, Shiyan, China; Department of Infectious Diseases, Renmin Hospital, Hubei University of Medicine, Shiyan, China Institute of Plant and Food Science, Department of Biology, School of Life Sciences, Southern University of Science and Technology (SUSTech), Shenzhen, Guangdong, China; Key Laboratory of Molecular Design for Plant Cell Factory of Guangdong Higher Education Institutes, Southern University of Science and Technology, Shenzhen, China Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia Department of Radiation Oncology, University of Electronic Science and Technology of China, Chengdu, China State Key Laboratory of Power Transmission Equipment &, System Security and New Technology Chongqing University 174 Shazheng Street, Shapingba District Chongqing City 400044 P. R. China Department of Hepatobiliary Surgery, Provincial Hospital affiliated to Shandong University, Jinan 250021, China Department of Geriatric Endocrinology, Chinese PLA General Hospital, National Clinical Center of Geriatric Medicine, Beijing 100853, P.R. China Hematology , Beijing , China State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology Chinese Academy of Sciences Beijing China; University of Chinese Academy of Sciences Beijing China School of Nursing, University of California, Los Angeles , Los Angeles, CA , USA; Department of Environmental Health Sciences, Fielding School of Public Health, University of California, Los Angeles , Los Angeles, CA , USA The Institute of Immunology, PLA, Third Military Medical University, Chongqing, P. R. China. Otorhinolaryngology Hospital The First Affiliated Hospital Sun Yat‐Sen University Guangzhou China Beijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Engineering and Technology Research Center of Food Additives, Beijing Technology and Business University, Beijing 100048, China Anhui Agricultural University, Hefei 230036, China; Key Laboratory of Agricultural Electronic Commerce of the Ministry of Agriculture, Hefei 230036, China a Key Laboratory for Green Chemical Technology of Ministry of Education, School of Chemical Engineering and Technology, Tianjin University , Tianjin , 300072 , P. R. China; b College of Material Science and Chemical Engineering, Tianjin University of Science and Technology , Tianjin , 300457 , P. R. China Department of Biostatistics and BioinformaticsTulane University School of Public Health and Tropical MedicineNew OrleansLAUSA; Center for Bioinformatics and GenomicsTulane University School of Public Health and Tropical MedicineNew OrleansLAUSA Department of Gastrointestinal and Thyroid Surgery, The Third Xiangya Hospital of Central South University, Changsha, Hunan�410013, P.R.�China NHC Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology and Center for AIDS Research, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, P. R. China. Department of Hematology, Chinese Academy of Medical Sciences and Peking Union Medical College Hospital, Beijing 100730, China Key Laboratory of Structure‐Based Drug Design and Discovery, Ministry of Education Shenyang Pharmaceutical University Shenyang 110016 China; School of Traditional Chinese Materia Medica Shenyang Pharmaceutical University Shenyang 110016 China School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA, USA School of Computer Science and Engineering, Yulin Normal University, Yulin, China. Faculty of Metallurgical and Energy Engineering, Kunming University of Science and Technology, Kunming 650093, China Cardiovascular Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215 Hefei National Laboratory for Physical Sciences at the Microscale and Department of Physics and CAS Key Laboratory of Strongly‐Coupled Quantum Matter Physics University of Science and Technology of China Hefei Anhui 230026 China Orthopedics Department, Yancheng City No. 1 People's Hospital, Yancheng, Jiangsu 224005, P.R. China State Key Laboratory of Applied Organic Chemistry, Lanzhou University Tianjin University National Engineering Laboratory for Hydrometallurgical Cleaner Production Technology, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, PR China; Key Laboratory of Green Process and Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, PR China; University of Chinese Academy of Sciences, Beijing 100049, PR China State Key Laboratory of Separation Membranes and Membrane Processes, Tiangong University, Tianjin 300387, People’s Republic of China Hospital of People's Liberation Army, China Laboratory of Veterinary Anatomy, College of Veterinary Medicine, China Agricultural University, Beijing, China Department of Medical Oncology, Chinese Academy of Medical Sciences, Beijing, China. Department of Surgery Jinqiu Hospital of Liaoning Shenyang China State Key Laboratory of Applied Organic Chemistry, Laboratory of Special Function Materials and Structure Design of the Ministry of Education, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China CAS Key Laboratory of Receptor Research, State Key Laboratory of Drug Research, Drug Discovery and Design Center, Laboratory of Immunopharmacology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China School of Physical Science and Technology, ShanghaiTech University, Shanghai, 201210, China The Key Laboratory of Geriatrics, Beijing Hospital and Beijing Institute of Geriatrics, Ministry of Health, Beijing 100730, China; Graduate School of Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, China Department of Pancreatic Cancer, National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China Department of Hematology Peking Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Union Medical College Beijing China Department of Chemistry, Shanghai University Monash Biomedicine Discovery Institute, Department of Microbiology, Monash University, Victoria, Australia Department of Maternal & Child Health, School of Public Health, Fudan University, Shanghai, China. School of Architecture Harbin Institute of Technology Harbin Heilongjiang China; Key Laboratory of Cold Region Urban and Rural Human Settlement Environment Science and TechnologyMinistry of Industry and Information Technology Harbin China State Key Laboratory of High Performance Ceramics and Superfine Microstructure; Shanghai Institute of Ceramics; Chinese Academy of Sciences; Shanghai 200050; China Facility for Anti-Infective Drug Development and Innovation, Drug Delivery, Disposition, and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia The Scripps Research Institute, BCC-239, 10550 North Torrey Pines Road, La Jolla, CA 92037 Department of Pediatric Hematology, Fujian Institute of Hematology, Fujian Provincial Key Laboratory, Fujian Medical University Union Hospital, Fuzhou 350001, Fujian Province, China,E-mail:1354113723@qq.com. State Key Laboratory of Cellular Stress Biology, Innovation Center for Cellular Signaling Network, School of Life Sciences, Xiamen University, Xiamen, China Department of General Surgery, The Third Hospital of Mianyang, Sichuan Mental Health Center Mianyang 621000, Sichuan, China. Chemistry & Chemical and Environmental Engineering College; Weifang University; Weifang 261061; China Departments of Hematology, Department of Chemistry, Innovative Drug Research Center, Shanghai University, 99 Shangda Road, Shanghai 200444, P. R. China Peking University Health Science Center, School of Pharmaceutical Sciences, Department of Pharmaceutics, Beijing 100191, People’s Republic of China Institute of Immunology, PLA, Third Military Medical University (Army Medical University), Chongqing 400038, China Department of Chemical Engineering, KU Leuven, Celestijnenlaan 200F, B-3001 Leuven, Belgium Department of Orthopaedics Hangzhou Ninth People's Hospital Hangzhou China Department of Oncology, Wuhan General Hospital of Guangzhou Command, People’s Liberation Army, China University of Pennsylvania Cardiovascular Institute, University of Pennsylvania, Philadelphia, PA 19104-4283, USA.; Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104-4283, USA. Department of Orthopedics the Fourth People's Hospital of Jinan, The Third Affiliated Hospital of Shandong First Medical University, Jinan, China From the Department of Neurology and Institute of Neurology (Y.Z., X.H., C.M., Y.Q., Y.L., S.X., X.Y., Q.X.), Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, China; Department of Neurology (X.L.), Zhoushan Branch of Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, China; Clinical Research Center (J.L.), Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, China; and Shanghai Institute of Nutrition and Health (Z.Y.), Chinese Academy of Sciences, China. Quanzhou Hospital of TCM, Fujian 362000, China. fjqz-lj@163.com Department of Radiology The First Hospital, China Medical University Shenyang Liaoning China Key Laboratory of Bio-Based Materials Science and Technology of Ministry of Education, Northeast Forestry University, Hexing Road 26, Harbin 150040, People’s Republic of China College of Bioengineering, Jimei University, Xiamen 361021, China. Department of Environmental Health Sciences, Fielding School of Public Health, School of Nursing, University of California Los Angeles, Los Angeles, CA, USA. Key Laboratory for Animal Disease‐Resistance Nutrition of the Ministry of Agriculture of China, Animal Nutrition Institute Sichuan Agricultural University Ya′an China Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University (Parkville campus), Parkville, Australia Department of Hematology Peking Union Medical College Hospital, Chinese Academy of Medical Sciences Beijing China Department of Otolaryngology‐Head and Neck Surgery The Third Medical Center of PLA General Hospital Beijing P.R. China MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, and Center for AIDS Research, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, PR China Institute of Occupational and Social Medicine Center for Health and Society Faculty of Medicine University of Düsseldorf Düsseldorf Germany; Institute of Medical Sociology Center for Health and Society Faculty of Medicine University of Düsseldorf Düsseldorf Germany Beijing National Laboratory for Molecular Sciences, State Key Laboratory of Rare Earth Materials Chemistry and Applications, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China; and Key Laboratory of Preventive Veterinary Medicine in Hubei Province, The Cooperative Innovation Center for Sustainable Pig Production, Wuhan, China Perelman School of Medicine and University of Pennsylvania Health System, Philadelphia (A.M.S., K.G., Z.A., J. Li, A.T.O., B.F., R.A., B.K.). Children’s Hospital and Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, China CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Pudong, Shanghai, China 201203. Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia Exploration and Development Research Institute of Shengli Oilfield, Sinopec, Dongying 257022, Shandong, China Clinical Research Center, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 200025 Shanghai, China; Department of Ophthalmology & Visual Sciences, The Chinese University of Hong Kong, Hong Kong, People's Republic of China National Center for Protein Sciences Beijing, State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Lifeomics, Beijing 102206, China School of Life Science and Technology, MOE Key Laboratory of Developmental Genes and Human Diseases, Southeast University 1 , Nanjing 210096 , China 6Department of Hepatobiliary Surgery, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, P.R. China. Key Laboratory of Hematology, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China. E-mail: jeniferjian@gmail.com. State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Biology, School of Life Sciences, Xiamen University Clinical Laboratory of the Third Xiangya Hospital, Central South University, Changsha, China Matec Instrument Companies, Inc., 56 Hudson Street, Northboro, Massachusetts 01532 Chengdu, Sichuan, China Department of Electrical and Computer Engineering, University of Florida , Gainesville, Florida 32611 Department of Prenatal Diagnostic Center, Guangzhou Women and Children's Medical Centre Guangzhou Medical University Guangzhou P.R. China Department of Gastrointestinal Oncology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital & Institute, 52 Fucheng Road, Haidian District, Beijing 100142, China The Key Laboratory of Geriatrics Beijing Hospital & Beijing Institute of Geriatrics Ministry of Health Beijing 100730 China Department of Hematology, The Second Hospital Affliated to Nanchang Universitor, Jiangxi Provincial Key Laboratory of Blood Deseases. E-mail:jeniferjian@gmail.com. Ministry-of-Education Key laboratory of Clinical Laboratory Diagnostics, Department of Laboratory Medicine, Chongqing Medical University, Chongqing 400016, China. Center of Molecular and Translational Medicine, Georgia State University, Atlanta, GA, USA School of Cyberspace Security, Beijing University of Posts and Telecommunications, Beijing 100876, China Arizona State University Material Science and Engineering Program, , Tempe, Arizona 85287, USA Institute of Materials Research and Engineering, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore. Key Laboratory of Bio-Based Material Science and Technology of Ministry of Education, Northeast Forestry University, Harbin 150040, China Endoscopy Center, Zhongshan Hospital, Fudan University, Shanghai, China Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Sciences, Nankai University, Tianjin, China Facility for Anti-Infective Drug Development and Innovation, Victorian College of Pharmacy, Monash University, Parkville, Victoria, Australia School of Information Engineering, Ningxia University, Yinchuan 750021, China; School of Cyberspace Security, Beijing University of Posts and Telecommunications, Beijing 100876, China School of Pharmaceutical Engineering & Life Sciences, Chang Zhou University, Changzhou, 213164, P. R. China, and School of Petrochemical Engineering, Chang Zhou University, Changzhou, 213164, P. R. China Department of Pulmonary Diseases, Affiliated Hospital, Jiangsu University, Zhenjiang 212001, China MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou 510631, China Department of Thoracic Surgery, Cancer Hospital (Institute), Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100021, China. Department of Reproduction and Development, Kunming Institute of Zoology, The Chinese Academy of Sciences, Kunming, Yunnan, China Department of Endocrinology, Shanghai Tenth People's Hospital and Tongji Eye Institute, Tongji University School of Medicine, Shanghai 200092, P.R. China The Key Laboratory of Geriatrics Beijing Institute of Geriatrics Beijing Hospital, National Center of Gerontology National Health Commission Institute of Geriatric Medicine Chinese Academy of Medical Sciences Beijing China School of Economics and Management, Shaoyang University, Shaoyang, Hunan 422000, China Division of Chemistry & Material Science US Food & Drug Administration, Center for Devices and Radiological Health, Office of Science and Engineering Laboratories Silver Spring Maryland 20993 State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine , Beijing , People’s Republic of China Institute of Pediatrics, Children's Hospital of Fudan University, and the Shanghai Key Laboratory of Medical Epigenetics, the International Co‐laboratory of Medical Epigenetics and Metabolism, the State Key Laboratory of Genetic Engineering, Institutes of Biomedical Sciences, Shanghai Medical College Fudan University Shanghai China The Key Laboratory of Geriatrics Beijing Institute of Geriatrics Beijing Hospital National Center of Gerontology National Health Commission Institute of Geriatric Medicine Chinese Academy of Medical Sciences Beijing 100730 P. R. China Department of Thoracic Surgery, Anyang Tumor Hospital, Anyang, China School of Mechanical, Aerospace, Chemical and Materials Engineering and Advanced Photovoltaics Center, Arizona State University, 7700 South River Parkway, Tempe, Arizona 85284, and University of Oulu, P.O. Box 4500, 90014 Oulun Yliopisto, Finland Department of Fibre and Polymer Technology KTH Royal Institute of Technology Teknikringen 56 10044 Stockholm Sweden Athinoula A. Martinos Center for Biomedical Imaging Massachusetts General Hospital and Harvard Medical School Massachusetts Charlestown USA; Department of Neurology, Center for Neurotechnology and Neurorecovery Massachusetts General Hospital and Harvard Medical School Massachusetts Boston USA Earth and Life Institute Catholic University of Louvain Louvain la Neuve 1348 Belgium Facility for Anti-infective Drug Development and Innovation, Monash Institute of Pharmaceutical Sciences, Monash University, Melbourne, Australia Engineering Research Center of Advanced Wooden Materials (Ministry of Education) Northeast Forestry University Harbin 150040 China Department of Chemistry; Tsinghua University; 100084 Beijing; China Department of Nuclear Medicine, XiangYa Hospital Central South University Changsha China School of Basic Medical Sciences, Beijing University of Chinese Medicine, Beijing 100029, China Department of Medical Oncology The First Affiliated Hospital of Anhui Medical University Hefei Anhui China First Affiliated Hospital, Heilongjiang University of Chinese Medicine Department of Orthopedics, Karolinska Hospital, Stockholm, Sweden Centre to Impact AMR, Monash University , Clayton, Australia; Infection Program, Monash Biomedicine Discovery Institute and Department of Microbiology, Monash University , Melbourne, Victoria, Australia Department of Chemistry Center for Supramolecular Chemistry and Catalysis Shanghai University Shanghai 200444 P.R. China Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China; Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou 215123, China Department of Laboratory Medicine, Xiangya School of Medicine, Central South University, Changsha 410013, China. Department of Cardiology, Huashan Hospital Fudan University, Shanghai, China Department of Cardiology, The Affiliated Hospital of Medical College, Qingdao University, Qingdao Shandong 266003, China Department of Clinical Laboratory Sun Yat‐Sen Memorial Hospital Sun Yat‐Sen University Guangzhou China Department of Urology The 452 Hospital of Western Air Force Chengdu China Department of Geriatric Endocrinology, Chinese People's Liberation Army General Hospital, Beijing 100853, P.R. China Shock and Vibration of Engineering Materials and Structures Key Laboratory of Sichuan Province, Mianyang 621999, China Institute of Semiconductors; Chinese Academy of Sciences; Beijing 100083; China; College of Materials Science and Opto-Electronic Technology Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of Zhejiang Province, Department of Cardiology, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, 310016, China State Key Laboratory of Bioorganic and Natural Products Chemistry Center for Excellence in Molecular Synthesis Shanghai Institute of Organic Chemistry University of Chinese Academy of Sciences Chinese Academy of Sciences 345 Lingling Road Shanghai 200032 China Children's Hospital and Institutes of Biomedical Sciences Key Laboratory of Medical Epigenetics and Metabolism Fudan University Shanghai China State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 P. R. China State Key Laboratory of Protein and Plant Gene Research, Peking-Tsinghua Center for Life Sciences, School of Advanced Agriculture Sciences and School of Life Sciences, Peking University, Beijing 100871, China Key Laboratory of DGHD, MOE, Institute of Life Sciences, Southeast University, Nanjing, China Department of Hepatobiliary Surgery, Hospital Affiliated to Chengde Medical University, 36 Nanyingzi Road, Chengde, 067000, China Department of Pharmacy, West China Hospital, Sichuan University, Chengdu 610041, P. R. China PetroChina Research Institute of Petroleum Exploration and Development, Beijing 100083, China Key Laboratory for Animal Disease Resistant Nutrition of the Ministry of Education, Animal Nutrition Institute, Sichuan Agricultural University, Chengdu 611130, China State Key Laboratory of Lead Compound Research, WuXi AppTec, Waigaoqiao Free Trade Zone, Shanghai, China Signal and Image Processing Institute, University of Southern California, Los Angeles CA, USA Wound Healing Center Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University Shanghai China Department of Otorhinolaryngology Head and Neck Surgery, First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China. Prenatal Diagnostic Center, Guangzhou Women and Children’s Medical Center, Guangzhou, China Department of Ultrasound, The Second Clinical Medical College, Jinan University (Shenzhen People’s Hospital), Shenzhen 518020, China Department of Chemistry, McMaster University, Hamilton, ON, Canada L8S 4M1 Department of Mathematics Florida State University Tallahassee FL 32306 USA Institute of Animal Nutrition, Key Laboratory for Animal Disease-Resistance Nutrition of China, Ministry of Education, Sichuan Agricultural University , Chengdu, Sichuan 611130 , China Department of Hepatobiliary and Pancreatic Surgery, Affiliated Hospital of Weifang Medical University, Weifang, Shandong 261031, P.R. China Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science & Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou 215123, P. R. China Department of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, Beijing 100850, China Jiangmen Key Laboratory of Synthetic Chemistry and Cleaner Production, School of Environmental & Chemical Engineering, Wuyi University, Jiangmen 529020, China State Key Laboratory of Experimental Hematology Institute of Hematology & Blood Diseases Hospital National Clinical Research Center for Blood Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College Tianjin China Key Laboratory of Beijing on Regional Air Pollution Control; College of Environmental and Energy Engineering; Beijing University of Technology; Beijing 100124; China College of Chemistry and Materials Science, College of Agronomy, Hunan Agricultural University, Changsha 410128, PR China State Key Laboratory of Lead Compound Research, WuXi AppTec, 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131, China Peoples' Hospital of Pubei, Pubei, China Tongji School of Pharmacy Huazhong University of Science and Technology Wuhan China; Yichang Central People's Hospital Yichang China State Key Laboratory of Microbial Technology, College of Life Science, Shandong University, Jinan 250100, China Biomedicine Discovery Institute, Infection & Immunity Program and Department of Microbiology, Monash University , Melbourne, VIC 3800, Australia Department of GI Oncology, Laboratory of Carcinogenesis and Translational Research of the Ministry of Education, Peking University School of Oncology, Beijing Cancer Hospital & Institute , Beijing , People’s Republic of China Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia College of Life Science and Technology, Southwest University for Nationalities, Chengdu, Sichuan 610041, China. Department of Nuclear Medicine Xiangya Hospital, Central South University Changsha Hunan China Department of Thoracic Surgery, Peking University First Hospital, Beijing, China. National Soybean Processing Industry Technology Innovation Center, Beijing Technology and Business University, Beijing 100048, China; Key Laboratory of Green and Low-Carbon Pocessing Technology for Plant-Based Food of China National Light Industry Council, Beijing Technology and Business University, Beijing 100048, China Prenatal Diagnostic Center Guangzhou Women and Children's Medical Center affiliated to Guangzhou Medical University Guangzhou Guangdong People's Republic of China Department of Hepatobiliary Surgery, The First Hospital of Changsha, Changsha, Hunan 410005, China Mannheim Institute of Public Health, Social and Preventive Medicine, Mannheim Medical Faculty, Heidelberg University Germany; Institute of Occupational and Social Medicine, University of Düsseldorf Germany; Department of Medical Sociology University of Düsseldorf Germany College of Food Science, Beijing Technology and Business University, Beijing 100048, China School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, Hangzhou 310024, China; CAS Key Laboratory of Receptor Research, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China; University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing 100049, China Endoscopy Center, Minhang Hospital, Fudan University, Shanghai, China Department of Prosthodontics, Peking University School and Hospital of Stomatology, Beijing, China. Root Biology Center, College of Resources and Environment, Fujian Agriculture and Forestry University, Fuzhou 350002, China The Center for Drug Discovery and Design, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, People's Republic of China College of Chemistry and Pharmacy, Northwest A&F University; Shaanxi Key Laboratory of Natural Products & Chemical Biology, 3 Taicheng Road, Yangling, 712100, Shaanxi, P. R. China Department of Plastic and Cosmetic Surgery, Nanfang Hospital Southern Medical University Guangzhou Guangdong China Key Laboratory of Carcinogenesis & Translational Research (Ministry of Education), Department of GI Oncology, Peking University School of Oncology, Peking University Cancer Hospital & Institute, 52 Fucheng Road, Haidian District, Beijing, 100142, China Department of Radiology, Tianjin Hospital, Tianjin, China; Department of Radiology, Tianjin Hospital, Tianjin, China Graduate School, Shanxi Medical University, Taiyuan, Shanxi 030000, P.R. China State Key Laboratory of Special Surface Protection Materials and Application Technology; Wuhan Research Institute of Materials Protection; Wuhan 430030; China Department of Otorhinolaryngology-Head and Neck Surgery, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China; Institute of Otorhinolaryngology-Head and Neck Surgery, Sun Yat-Sen University, Guangzhou, China Prenatal Diagnostic Center, Guangzhou Women and Children Medical Center affiliated to Guangzhou Medical University, Guangzhou, Guangdong, People’s Republic of China; 2 Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus), Parkville, Victoria 3052, Australia Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, China, and Department of Chemistry, Nanchang University, Nanchang 330047, China Department of Hepatobiliary Surgery, Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, China Institute of Systems Engineering, China Academy of Engineering Physics, Mianyang 621999, Sichuan, China Department of Acute Infectious Disease Control and Prevention, Shanghai Municipal Center for Disease Control and Prevention, Shanghai 200336, China. Biomedicine Discovery Institute, Infection & Immunity Program and Department of Microbiology, Monash University, Melbourne, Australia State Key Laboratory of Catalysis, 2011-Collaborative Innovation Center of Chemistry for Energy Materials, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Zhongshan Road 457, Dalian 116023, China. Department of Hepatobiliary and Pancreatic Surgery, Affiliated Hospital of Weifang Medical University, Weifang, P.R. China. Facility for Anti-infective Drug Development and Innovation, Victorian College of Pharmacy, Monash University, Parkville, Victoria, Australia Department of Obstetrics and Gynecology, the First Hospital Affiliated to Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang 150040, China. Department of Obstetrics and Gynecology, Prince of Wales Hospital of the Chinese University of Hong Kong, Hong Kong 999077, China. School of Physical Science and Technology ShanghaiTech University Shanghai 201210 China Department of Ophthalmology, Changshu No. 2 People’s Hospital, Changshu, Jiangsu, China (mainland) National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China Department of Thoracic Surgery, West China Hospital Sichuan University Chengdu China College of Mechanical and Electrical Engineering, Department of Mechanical Engineering, Northeast Forestry University, Harbin, China. Biomedicine Discovery Institute, Department of Microbiology, Monash University, Clayton, Victoria, Australia Sports Medicine Center, West China Hospital, Sichuan University, Chengdu, SC, China Department of Gastrointestinal Oncology, Key Laboratory of Carcinogenesis & Translational Research (Ministry of Education), Peking University Cancer Hospital & Institute, No. 52 Fu-Cheng Road, Hai-Dian District, Beijing 100142, China 1Biology of Aging Laboratory, Department of Geriatrics, Geneva University Hospitals, Geneva 1225, Switzerland Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang 550000, China Beijing Genomics Institute/Center of Genomics and Bioinformatics, Chinese Academy of Sciences, Beijing 101300, China. Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, California 90095 (S.X.L., H.L., S.M.K., E.M.T., C.L.); Hebei Key Laboratory of Molecular Cell Biology, College of Biological Sciences, Hebei Normal University, Shijiazhuang 050016, Hebei, China (J.L., L.M.) Department of Hematology, Peking Union Medical College Hospital, Beijing, China Department of Orthopaedics, West China Hospital, Sichuan University, Chengdu, P.R. China. PetroChina Tarim Oilfield Company, Korla 841000, China Geriatrics Department, Tongji Hospital Affiliated to Tongji University Medical School Shanghai 200065, China. Department of Engineering Mechanics; Zhejiang University; Hangzhou; P. R. China State Key Laboratory of Lead Compound Research, WuXi AppTec, Co., Ltd, Shanghai 200131, China Center for Translational Medicine Research and Development Shenzhen Institutes of Advanced Technology and Chinese Academy of Sciences Shenzhen China The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital/National Center of Gerontology National Health Commission Beijing China Keck Center for Cellular Dynamics & Department of Physiology, Morehouse School of Medicine, Atlanta, GA, USA Department of General Surgery, The Third Hospital of Mianyang, Sichuan Mental Health Center, Mianyang 621000, Sichuan, China Material Science and Engineering Arizona State University Tempe AZ 85287 USA Department of Electrical and Computer Engineering, University of Florida 3 3 Gainesville, FL 32611, USA Gastrointestinal Oncology Division of Pathology, the Cancer Institute Japanese Foundation for Cancer Research Tokyo Japan; Department of Pathology Peking University Shenzhen Hospital No. 1120, Lianhua North Road Shenzhen China Department of Biomedical Engineering City University of Hong Kong Kowloong Tong Hong Kong 999077 P. R. China; Hong Kong Center for Cerebra‐Cardiovascular Health Engineering Hong Kong Science Park New Territories Hong Kong 999077 P. R. China State Key Laboratory of Catalysis; National Laboratory for Clean Energy; 2011-Collaborative Innovation Center of Chemistry for Energy Materials; Dalian Institute of Chemical Physics; Chinese Academy of Sciences Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, P.R. China Department of Colorectal and Anal Surgery, Xiangya Hospital, Central South University, Changsha 410008. lijian869@163.com. Department of Prosthodontics School and Hospital of Stomatology and National Clinical Research Center for Oral Diseases Peking University Beijing China Laboratory of Antimicrobial Systems Pharmacology, Department of Microbiology, Biomedicine Discovery Institute, Monash University, Melbourne, VIC, Australia. Jian.Li@monash.edu. University of Florida Department of Electrical and Computer Engineering, , Gainesville, Florida, 32611 State Key Laboratory for Physical Chemistry of Solid Surfaces; Department of Chemical Biology; College of Chemistry and Chemical Engineering; The Key Laboratory for Chemical Biology of Fujian Province; The MOE Key Laboratory of Spectrochemical Analysis & Instrumentation The First Department of General Surgery, Affiliated Hospital of Chengde Medical University, Chengde, Hebei Province, PR China WuXi AppTec (Shanghai) Co., Ltd., 288 FuTe Zhong Road, Shanghai 200131, P. R. China Department of Nuclear Medicine, Xiangya Hospital Central South University Changsha China Laboratory of Carcinogenesis and Translational Research for the Ministry of National Education, Department of GI Oncology, Peking University School of Oncology, Beijing Cancer Hospital and Institute, Beijing 100142, China. College of Food and Biological Engineering, Jimei University, Xiamen 361021, China State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China Department of Pediatrics, Second Xiangya Hospital, Central South University Changsha 410011, Hunan, China. Department of Neurology II Affiliated Hospital of Weifang Medical University Weifang Shandong China Experimental Teaching Center of Environment and Cleaner Production in Chemical Industry, Key Laboratory for Green Chemical Process of Ministry of Education, School of Chemical Engineering & Pharmacy, Wuhan Institute of Technology, No. 693, Xiongchu Street, Hongshan District, Wuhan 430073, China Department of Orthopaedics Ⅱ, China Aerospace Science & Industry Corporation 731 Hospital, Beijing, China Department of Neurosurgery, Changshu No. 2 People's Hospital, The Affiliated Changshu Hospital of Xuzhou Medical University, Changshu, Suzhou, Jiangsu 215500, P.R. China Chinese Academy of Sciences; Institute of Optics and Electronics, Chinese Academy of Sciences; University of Chinese Academy of Sciences Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia; Prenatal Diagnostic Center, Guangzhou Women and Children’s Medical Center affiliated to Guangzhou Medical University, Guangzhou, Guangdong Province, People’s Republic of China; Department of Rheumatology and Lupus Research Institute, Affiliated Hospital of Jining Medical University , Jining, Shandong, China From the Angiogenesis Research Center, Cardiovascular Division, Department of Medicine (J.L., R.J.L., R.V., M.S.), and the Department of Pathology (L.F.B.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Mass. Center for Nanoscale Characterization & Devices (CNCD), Wuhan National Laboratory for Optoelectronics (WNLO)-School of Physics, Huazhong University of Science and Technology (HUST), 1037 Luoyu Road, Wuhan 430074, China Department of Orthopaedic Surgery University of Pittsburgh Suite 216, Bridgeside Point II, 450 Technology Drive, Pittsburgh Pennsylvania 15219 USA; Beijing Friendship Hospital Capital Medical University Beijing China Clinical Laboratory Center Children’s Hospital of Fudan University Shanghai China; Shanghai Key Laboratory of Birth Defect Shanghai China Department of Prenatal Diagnostic Center, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, P. R. China School of Environmental and Chemical Engineering Yanshan University Qinhuangdao Hebei Province China Department of Gastrointestinal Oncology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital & Institute, Beijing, China School of Foundations, Leadership, and Administration, Kent State University, Kent,OH, USA Department of Chemistry; Capital Normal University; Beijing P. R. China Department of Hematology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital Chinese Academy of Medical Sciences & Peking Union Medical College, Dongcheng District Beijing 100730 China Department of Thyroid Head and Neck Surgery, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang City, Liaoning Province 110801, China School of Environmental Science and Engineering, Tianjin University, Tianjin 300072, China State Key Laboratory of Cardiovascular Disease, FuWai Hospital, National Center for Cardiovascular Diseases Peking Union Medical College & Chinese Academy of Medical Sciences Beijing China Department of Geriatric, Tongji Hospital Affiliated to Tongji University Shanghai, China. Guangdong Provincial Academy of Building Research, Guangzhou 510500, China College of Bioengineering, Beijing Polytechnic, Beijing, 100029, China Department of Psychology and Behavioral Sciences, Zhejiang University, Hangzhou 310030, China MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, and Center for AIDS Research, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, P.R. China. Department of Joint Surgery, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Shandong, China; Department of Joint Surgery, Binzhou Medical University Hospital, Shandong, China Jiangsu Design Institute of Geology for Mineral Resources (Testing Center of China National Administration of Coal Geology); Xuzhou 221000; China MOE Key Laboratory of Macromolecule Synthesis and Functionalization of Ministry of Education Department of Polymer Science and Engineering Zhejiang University Hangzhou Zhejiang Province 310027 P. R. China; Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of Zhejiang Province Department of Cardiology Sir Run Run Shaw Hospital Zhejiang University School of Medicine Hangzhou 310016 P. R. China Drug Delivery; Disposition and Dynamics; Monash Institute of Pharmaceutical Science; Parkville; Australia Southeast University Drug Delivery, Disposition and Dynamics; Monash Institute of Pharmaceutical Sciences; Monash University; Parkville Victoria Department of Veterinary Medicine, College of Animal Sciences Zhejiang University No. 866 Yuhangtang Road Hangzhou 310058 People's Republic of China State Key Laboratory of Stress Cell Biology, School of Life Sciences, Xiamen University, Xiamen, Fujian 361005, People's Republic of China;; Laboratory of Malaria and Vector Research, and Department of Chemistry and Key Lab of Organic Optoelectronics & Molecular Engineering; Tsinghua University; Beijing, P. R. China Facility for Anti-Infective Drug Development and Innovation, Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Clayton, Victoria, Australia Suzhou Municipal Center for Disease Control and Prevention, Suzhou 215007, China Department of Neuroscience and Center for Reproductive Medicine, Dalian Women and Children’s Medical Center (Group), Dalian 116037, China Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Victoria, Australia; Monash Biomedicine Discovery Institute, Department of Microbiology, Monash University, Victoria, Australia State Key Laboratory of Bioorganic and Natural Products Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203, People’s Republic of China; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Qixia District, Nanjing 210023, People’s Republic of China Key Laboratory of Organic Synthesis of Jiangsu Province; College of Chemistry; Chemical Engineering and Materials Science & Collaborative Innovation Centre of Suzhou Nano Science and Technology; Soochow University; China ARC Centre of Excellence in Convergent Bio‐Nano Science and Technology Monash Institute of Pharmaceutical Sciences Monash University Parkville VIC 3052 Australia Laboratory of Green and Low‐carbon Processing Technology for Plant‐based Food of China National Light Industry Council, and Beijing Advanced Innovation Center for Food Nutrition and Human Health Beijing Technology and Business University Beijing China Key Laboratory of Bio‐based Material Science and Technology Ministry of Education Northeast Forestry University Harbin 150040 P. R. China Department of Psychology, Beijing Key Laboratory of Behavior and Mental Health, Peking University; PKU-IDG/McGovern Institute for Brain Research, Peking University State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei‐MOST) & Key Laboratory of Oral Biomedicine Ministry of Education (KLOBM) School and Hospital of Stomatology Wuhan University Wuhan China Beijing National Laboratory for Molecular Sciences, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China PET Center, Department of Nuclear Medicine, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China Biomedicine Discovery Institute, Monash University, Melbourne, Victoria, Australia.; Department of Microbiology, Monash University, Melbourne, Victoria, Australia. Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao, China; The MOH Key Laboratory of Geriatrics Beijing Hospital, National Center of Gerontology Beijing China Key laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Gastrointestinal Oncology, Peking University Cancer Hospital & Institute, Beijing, China Tianjin Medical University General Hospital Department of Neurosurgery, , Heping district, Tianjin , China Chemistry & Chemical and Environmental Engineering College, Weifang University, Weifang 261061, People’s Republic of China Department of Cardiology, Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular disease, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University, Tianjin, People's Republic of China Department of Chemistry, Innovative Drug Research Center, Shanghai University, 99 Shangda Road, Shanghai 200444, P. R. China; Shanghai Key Laboratory of High Temperature Superconductors, Shanghai University, Shanghai, 200444, P. R. China Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China School of Chemistry and Chemical Engineering, Yulin University, Yulin 719000, China Key Laboratory of Sustainable Development of Marine Fisheries Ministry of Agriculture, China Yellow Sea Fisheries Research Institute Chinese Academy of Fishery Sciences Qingdao China; Function Laboratory for Marine Fisheries Science and Food Production Processes Qingdao National Laboratory for Marine Science and Technology Aoshanwei Town Jimo, Qingdao China Department of Applied Chemistry; College of Chemistry and Chemical Engineering; Chongqing University; Chongqing 400030, P. R. China Key Laboratory of Combinatorial Biosynthesis and Drug Discovery Ministry of Education Wuhan University School of Pharmaceutical Sciences Wuhan University Wuhan P. R. China Department of General Surgery, The Affiliated Cancer Hospital of Nanjing Medical University & Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research, Baiziting 42, Nanjing 210029, PR China State Key Laboratory of Stem Cell and Reproductive Biology Institute of Zoology Chinese Academy of Sciences Beijing China State Key Laboratory of Biocontrol, Guangdong Provincial Key Laboratory of Plant Resources, School of Life Sciences Sun Yat‐sen University Guangzhou 510275 China; Key Laboratory of South China Agricultural Plant Molecular Analysis and Genetic Improvement & Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden Chinese Academy of Sciences Guangzhou 510650 China Department of Thoracic Surgery, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China Allergy Center, Otorhinolaryngology Hospital the First Affiliated Hospital of Sun Yat‐sen University Guangzhou China Zhejiang Provincial People’s Hospital, affiliated with Hangzhou Medical College , Hangzhou, Zhejiang Province, China Department of Chemical and Biological Engineering, Chemistry of Life Processes Institute, Northwestern University, Evanston, Illinois 60208, United States Department of Neurosurgery, Taian Central Hospital Taian 271000, Shandong, China. Department of Haematology, Te Whatu Ora Health New Zealand - Waitemata, Auckland, New Zealand Department of Orthopedics, Beijing Chao-yang Hospital, Capital Medical University, Beijing, China Department of Oncology, Shanghai Fourth People's Hospital Tongji University School of Medicine Shanghai China Department of Intensive Care Unit and Key Laboratory for Critical Care Medicine of the Ministry of Health, Emergency Medicine Research Institute, Tianjin First Center Hospital, Tianjin 300192, P.R. China Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences/Peking Union Medical College, Beijing 100730, China; Department of Pancreatic Cancer, Tianjin Medical University Cancer Institute & Hospital, Tianjin 300060, China Department of General Surgery, The Third People’s Hospital of Mianyang Sichuan Mental Health Center, Mianyang, Sichuan, China. Animal Nutrition Institute; Sichuan Agricultural University; Chengdu; China; Key Laboratory of Animal Disease-Resistant Nutrition of Ministry of Education State Key Laboratory of Proteomics; National Center for Protein Sciences (Beijing); Beijing Institute of Lifeomics; Beijing Proteome Research Center; Beijing 102206 Shanxi Medical University, Taiyuan, China. Biomedicine Discovery Institute & Department of Microbiology, Monash University, Melbourne 3800, Australia Cardiology DivisionDepartment of Medicine Department of Laboratory Medicine, Xiangya School of Medicine, Central South University, Changsha 410008, China. Department of Orthopedics Affiliated Hospital of Xiangnan University Chenzhou China Department of Plastic and Cosmetic Surgery, Nanfang Hospital Southern Medical University Guangzhou P.R. China Penn Cardiovascular Institute, Molecular Cardiology Research Center, University of Pennsylvania, Philadelphia, PA 19104 State Key Laboratory of Photocatalysis on Energy and Environment, Fuzhou University, Fuzhou 350002, China Monash Biomedicine Discovery Institute, Department of Microbiology, Monash University, Clayton, VIC 3800, Australia Key Laboratory of Optoelectronic Chemical Materials and Devices (Ministry of Education), Jianghan University, Wuhan 430056, China; Hubei Key Laboratory of Plasma Chemistry and Advanced Materials, School of Materials Science and Engineering, Wuhan Institute of Technology, Wuhan 430205, China Department of Hepatobiliary Surgery, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, China Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Florida, Gainesville, FL, U.S.A. Department of Digestive Disease, Peking University, School of Oncology, Beijing Cancer Hospital, Beijing Institute for Cancer Research, Beijing 100036, China. State key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, RP China; University of the Chinese Academy of Sciences, Beijing, RP China Department of Cardiac Surgery ICU Tianjin Chest Hospital Tianjin China Key Laboratory of Bio-based Material Science and Technology, Ministry of Education, Northeast Forestry University, Harbin 150040, P. R. China Laboratory of Malaria and Vector Research, and; State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, Fujian 361005, People’s Republic of China; Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Melbourne, Victoria, Australia Anyang Tumor Hospital Anyang Tumor Hospital affiliated to Henan University of Science and Technology Henan Key Medical Laboratory of Precise Prevention and Treatment of Esophageal Cancer Anyang 455001 P. R. China Key Laboratory of Green and Low-Carbon Processing Technology for Plant-Based Food of China National Light Industry Council, Beijing Technology and Business University, No. 33 Fucheng Road, Beijing 100048, China Clinical Research Center, Ruijin Hospital Affiliated to Shanghai Jiao Tong University, Shanghai 200025, China. Corresponding author: Zhang Xuemin, Email: zhangxm922@126.com. Department of Chemistry; Key Lab of Organic Optoelectronic and Molecular Engineering; Tsinghua University; 100084 Beijing; China Department of Anesthesiology, Changzheng Hospital Affiliated to the Second Military Medical University, Shanghai 200003, China Department of Cardiovascular Medicine, The First Hospital of China Medical University , Shenyang 110001 , Liaoning Province , China Department of Cardiology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong Province, China Department of Pediatrics,; Department of Pathology, and Department of Anatomy, Chengdu Medical College, Chengdu, Sichuan 610500, P.R. China College of Science Northwest A&F University Yangling Shaanxi China College of Bioinformatics Science and Technology, Harbin Medical University, Heilongjiang, China Department of Thoracic Surgery, Affiliated Hospital of Zunyi Medical College, Zunyi, Guizhou 563000, P.R. China Department of Orthopaedic, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510000, P.R.�China Department of Chemical Engineering, McMaster University, Hamilton L8S 4L7, Canada 1 School of Agriculture and Biology, Shanghai Jiaotong University, Shanghai 200240, People's Republic of China and 2School of Medicine, University of Missouri—Kansas City, Kansas City, MO 64108, USA Key Laboratory for Quantum Materials of Zhejiang Province, Department of Physics, Westlake University, Hangzhou, Zhejiang 310024, China; Institute of Natural Sciences, Westlake Institute for Advanced Study, Hangzhou, Zhejiang 310024, China Department of Orthopaedic Surgery, West China Hospital, Chengdu, China Department of Biostatistics and BioinformaticsTulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA Department of Orthopedic Surgery and Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu, China. Animal Husbandry and Veterinary Station of Qilian County, Qilian, Qinghai Province of the People’s Republic of China College of Plant Protection, Nanjing Agricultural University, Nanjing, China; State & Local Joint Engineering Research Center of Green Pesticide Invention and Application, Jiangsu, China State Key Laboratory of Analytical Chemistry for Life Science and Collaborative Innovation Center of Chemistry for Life Sciences School of Chemistry and Chemical Engineering Nanjing University Nanjing 210093 P. R. China College of Animal Science & Technology, Guangxi University, Nanning, China WuXi AppTec Co. Ltd., Shanghai, China Department of Function, Huizhou Central Hospital, Huizhou 516001, China. College of Chemistry and Molecular Engineering; Peking University; Beijing; China Biomedicine Discovery Institute and Department of Microbiology, Monash University, Melbourne, VIC 3800, Australia d Key Laboratory for Green Chemical Technology of Ministry of Education, School of Chemical Engineering and Technology, Tianjin University, 92 Weijin Road, Nankai District Tianjin 300072, P. R. China; State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, P. R. China Department of Orthopedic Surgery, West China Hospital of Sichuan University, Chengdu, China. Department of Anesthesiology Laboratory of Anesthesiology and Critical Care Medicine Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei PR China Department of Chemical and Biological Engineering Northwestern University Evanston IL USA; Chemistry of Life Processes Institute Northwestern University Evanston IL USA; Robert H. Lurie Comprehensive Cancer Center Northwestern University Chicago IL USA; Simpson Querrey Institute for BioNanotechnology in Medicine Northwestern University Chicago IL USA Department of Psychology, New York UniversityNew York, NY 10003, USA Center for Translational Medicine Research and Development Shenzhen Institute of Advanced Technology Chinese Academy of Sciences Shenzhen 518055 China Graduate School, Guangzhou University of Chinese Medicine, Guangzhou, 510405, China. Pathology, Peking University Shenzhen Hospital, Shenzhen, China; State Key Laboratory of Chemical Oncogenomics, Peking University Shenzhen Graduate School, Shenzhen, China Osteoporosis Research Center and Department of Biological Sciences, Creighton University, Omaha, Nebraska 68131 Department of Material Science and Engineering, Arizona State University, Tempe, Arizona 85284, United States Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, The Chinese Academy of Sciences, Beijing 100190, P.R. China Northeast Forestry University Chemistry CHINA Department of Hepatobiliary Surgery, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, People’s Republic of China School of Materials Science & Engineering; Changzhou University; Changzhou 213164; China Facility for Anti-Infective Drug Development and Innovation, Monash Institute of Pharmaceutical Sciences, Monash University, Melbourne Beijing System Design Institute of the Electro-mechanic Engineering Beijing 100854 P. R. China College of Life Science and Technology Southwest Minzu University Chengdu China; Key Laboratory of Qinghai‐Tibetan Plateau Animal Genetic Resource Reservation and Utilization Ministry of Education Qinghai‐Tibetan Plateau Animal Genetic Resource Reservation and Utilization Key Laboratory of Sichuan Province Chengdu China Biomedicine Discovery Institute, Infection and Immunity Program, Department of Microbiology, Monash University, Clayton, Victoria, Australia School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210023, China; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203, China Contribution from Drug Discovery, Johnson & Johnson Pharmaceutical, Research & Development, Spring House, Pennsylvania 19477-0776 Department of GI Oncology, Key laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University School of Oncology, Beijing Cancer Hospital & Institute, Beijing, China Prenatal Diagnostic Center, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, People’s Republic of China; Material Science and Engineering College; Northeast Forestry University; Harbin 150040; PR China Facility for Anti-infective Drug Development and Innovation Victorian College of Pharmacy Monash University 381 Royal Parade Parkville, Victoria 3052, Australia Department of Hepatobiliary and Pancreatic Surgery The First Affiliated Hospital of Zhengzhou University Zhengzhou China; Institute of Hepatobiliary and Pancreatic Diseases Zhengzhou University Zhengzhou China; Key Lab of Hepatobiliary and Pancreatic Diseases Zhengzhou China State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, People’s Republic of China Institute of Experimental Immunology University Clinic of Rheinische Friedrich‐Wilhelms‐University Bonn Germany National Key Laboratory of Mariculture Biobreeding and Sustainable Goods, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao 266071, China; Laboratory for Marine Fisheries Science and Food Production Processes, Qingdao National Laboratory for Marine Science and Technology, Qingdao 266071, China Endoscopy Center, Minhang Hospital, Fudan University, Shanghai 201199, China Department of Cardiology, Southeast University Medical College, Jiangyin, China. Berzelii Center EXSELENT on Porous Materials Department of Materials and Environmental Chemistry Stockholm University Stockholm 10691 Sweden Key Laboratory of Beijing on Regional Air Pollution Control, Beijing University of Technology, Beijing, People’s Republic of China The MOH Key Laboratory of Geriatrics, Beijing Hospital, National Center of Gerontology, Beijing 100730, P.R. China Department of Pathology, The First Affiliated Hospital of Xinxiang Medical University Xinxiang 453003, Henan, China. Biomedicine Discovery Institute, Infection & Immunity Program and Department of Microbiology, Monash University, Clayton Campus, Melbourne, VIC, Australia. jian.li@monash.edu. Biomedicine Discovery Institute and Department of Microbiology , Monash University, Melbourne, VIC 3800 , Australia 1Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Boston, MA 02115; 2Department of Medicine Department of Neurology, Thomas Jefferson University, Philadelphia, PA 19107, USA From the Department of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Shanghai Jiao Tong University School of Medicine (D.L., Y.W., L.Z., H.N., K.W., Y.S., W.C., J.L.); Department of Cardiology, Huashan Hospital, Fudan University, (X.L., J.L.); Department of Laboratory Animal Sciences, Shanghai Jiao Tong University School of Medicine (X.C.); Division of Thrombosis and Hemostasis, Ruijin Hospital, Affiliated to Shanghai Jiao Tong... Cardiovascular Division and; Angiogenesis Research Center, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215; Key Laboratory for Animal Disease Resistance Nutrition of the Ministry of Education, Animal Nutrition Institute, Sichuan Agricultural University, Chengdu, China Department of Family Planning, Beijing Obstetrics and Gynecology Hospital, Capital Medical Universityy, Beijing, China (mainland) Department of Hematology, Union Hospital of Peking Union Medical College, Beijing 100730, China. E-mail: pumch.li.jian@gmail.com. College of Chemistry and Chemical Engineering, Yulin University, Yulin 719000, China School of Information and Communication Engineering, North University of China, Taiyuan 030051, China Drug Delivery, Disposition & Dynamics, Monash Institute of Pharmaceutical Sciences, 381 Royal Parade Parkville 3052, Victoria, Australia. . Key Laboratory of Bio-Based Material Science & Technology, Ministry of Education, Northeast Forestry University, Harbin 150040, China Key Laboratory of Nuclear Medicine of Ministry of Health, Jiangsu Institute of Nuclear Medicine, Wuxi, Jiangsu 214063, P.R. China Department of Materials Science and Engineering Arizona State University Tempe AZ 85284 USA College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, Daqing 163319, China. Department of Biological Engineering, School of Environment and Chemistry Engineering, Yanshan University, 438 Hebei Street, Qinhuangdao 066004, P.R. China. ‡Department of Global Biostatistics and Data Science, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA 70112 Orthopaedics, Affiliated Hospital of Xiangnan College, Chenzhou, 423000 Hunan, China College of Animal & Veterinary Southwest Minzu University Chengdu Sichuan China; Key Laboratory of Qinghai‐Tibetan Plateau Animal Genetic Resource Reservation and Utilization Ministry of Education Chengdu Sichuan China Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Gastrointestinal Oncology Peking University Cancer Hospital & Institute Beijing China The Second Department of Gastroenterology, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China; Wuhan Research Institute of Materials Protection; Wuhan 430030; China *Laboratory of Biology of Aging, Department of Rehabilitation and Geriatrics, and Key Laboratory of Bio-based Materials Science and Technology of Ministry of Education, Northeast Forestry University, 26th Hexing Road, Xiangfang District, Harbin 150040, P. R. China; Research Center of Wood Bionic Intelligent Science, Northeast Forestry University, 51th Hexing Road, Xiangfang District, Harbin 150040, P. R. China Department of Endocrinology, People’s Hospital of Liaocheng, Shandong 252000, China Department of Radiation Oncology Key Laboratory for Animal Disease Resistance Nutrition of the Ministry of Education, Animal Nutrition Institute, Sichuan Agricultural University, Chengdu 611130, People’s Republic of China Organisch-Chemisches Institut Universität Heidelberg Im Neuenheimer Feld 270 69120 Heidelberg Germany Key Laboratory of Low-Grade Energy Utilization Technologies and Systems, Ministry of Education, Chongqing University, Chongqing 400044, P. R. China; School of Energy and Power Engineering, Chongqing University, Chongqing 400044, P. R. China School of Environmental Science; Nanjing Xiaozhuang University; 3601 Hongjing Road Nanjing Jiangsu 211171 China University of Electronic Science and Technology of China Facility for Anti-Infective Drug Development and Innovation Department of Otolaryngology, The First Affiliated Hospital Sun Yat‐sen University Guangzhou China; Guangzhou Key Laboratory of Otorhinolaryngology Guangzhou China Department of Pediatric Hematology Fujian Medical University Union Hospital Fuzhou Fujian China Tulane University School of School of Public Health and Tropical Medicine, New Orleans, Louisiana, USA Department of Cardiology, The Affiliated Hospital of Medical College, Qingdao University, Qingdao, China Beijing Key Laboratory of Photoelectronic/Electrophotonic Conversion Materials; Key Laboratory of Cluster Science of Ministry of Education; School of Chemistry and Chemical Engineering; Beijing Institute of Technology; Beijing 100081 Guangdong Key Laboratory of Chiral Molecule and Drug Discovery; School of Pharmaceutical Sciences; Sun Yat-sen University; Guangzhou; P. R. China Key Laboratory of Bio-Based Material Science and Technology of Ministry of Education, Northeast Forestry University, Hexing Road 26, Harbin 150040, P.R. China Department of Cardiology, Jiangyin Hospital Affiliated to Medical College of Southeast University Laboratoire d'Etude de l'Hématopoièse, Etablissement de Transfusion Sanguine, Besançon, France Key Laboratory for Animal Disease Resistance Nutrition of the Ministry of Education of China, Animal Nutrition Institute, Sichuan Agricultural University, Chengdu, China Department of Hematology, Chinese Academy of Medical Sciences and Peking Union Medical College Hospital; and, Beijing, China. Department of Rheumatology and Lupus Research Institute, The Affiliated Hospital of Jining Medical University Department of Genetics, North Carolina State University, Raleigh, North Carolina 27695 School of Biotechnology and Health Sciences; Wuyi University; Jiangmen; 529020 China Drug Delivery, Disposition and Dynamics, and ‡Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville 3052, Victoria, Australia State Key Laboratory of Seedling Bioengineering Department of Orthopedics, Lishui Municipal Central Hospital, Lishui, Zhejiang, China (mainland) State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu chong zhi Road, Shanghai 201203, China State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China 1; Department of Reproductive Medicine, Peking University Shenzhen Hospital, Shenzhen Peking University–The Hong Kong University of Science and Technology Medical Center, Shenzhen, China 2 Center of Molecular and Translational Medicine, Georgia State University, Atlanta, Georgia Cardiovascular Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts; Department of Gynecology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China Materials Science and Engineering, Arizona State University, Tempe, Arizona 85287, United States Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Boston, MA, USA; Department of Medicine, Harvard Medical School, Boston, MA, USA. Department of Traumatic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China Beijing Key Laboratory of Rehabilitation Technical Aids for Old-Age and Disability and Key Laboratory of Rehabilitation Aids Technology and System of the Ministry of Civil Affairs and Engineering Research Center for Rehabilitation Aids of the Ministry of Civil Affairs, National Research Center for Rehabilitation Technical Aids, Beijing 100176, China; Robotic Institute, Beihang University, Beijing 100191, China State Key Laboratory for Powder Metallurgy, Central South University, Changsha 410083, China Aerospace Institute of Advanced Material & Processing Technology, Beijing 100074, P. R. China Department of Pathology, Second Xiangya Hospital, Central South University, Changsha 410011, China. Nanjing Normal University 1 Department of Physics, , Nanjing 210023, China School of Basic Medical Sciences, Beijing University of Chinese Medicine, No. 11, North Third Ring Road, Chaoyang District, Beijing 100029, China Department of Orthopaedics, West China Hospital, Sichuan University, Chengdu Sichuan 610041, P R China. Material Science and Engineering, Arizona State University, Tempe, Arizona 85287, United States School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China Hematology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China. Department of Medical Oncology, Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100021, China. Shanghai Ocean University, Shanghai 201306, PR China; Laboratory for Marine Fisheries and Aquaculture, Qingdao National Laboratory for Marine Science and Technology/Key Laboratory of Sustainable Development of Marine Fisheries, Ministry of Agriculture, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao, 266071, PR China Department of Chemistry; Center for Supramolecular Chemistry and Catalysis; Shanghai University; Shanghai 200444; P. R. China From the State Key Laboratory of Oncology in South China and Sun Yat-sen University Cancer Center, Guangzhou, People's Republic of China. Department of Cardiovascular surgery, Second Affiliated Hospital, Army Medical University, Chongqing, China. Department of Environmental Health Sciences Fielding School of Public Health School of Nursing University of California Los Angeles CA Tianjin Key Laboratory of Ionic‐Molecular Function of Cardiovascular Disease Department of Cardiology Tianjin Institute of Cardiology Second Hospital of Tianjin Medical University Tianjin China Laboratory of Renewable Energy Science and Engineering, Institute of Mechanical Engineering, EPFL, Station 9, 1015Lausanne, Switzerland The First Department of General Surgery, Affiliated Hospital of Chengde Medical University, Chengde City, Hebei Province, 067000, China Beijing Institute of Veterinary Drugs Control Beijing P. R. China Department of Plastic and Cosmetic Surgery, Nanfang Hospital, Southern Medical University, Guang Zhou, Guang Dong, P. R., China Key Laboratory of Green and Low-Carbon Processing Technology for Plant-Based Food of China National Light Industry Council, Beijing Technology and Business University, Beijing 100048, China Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University, China Department of Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Ave, Rm C-278, New York, NY 10065. Geriatrics Department, Tongji Hospital Affiliated to Tongji University Medical School, Shanghai, 200065, China Epigenome Center, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA. State Key Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Chaoyang District, Beijing 100101, China Department of Hematology, Chinese Academy of Medical Sciences and Peking Union Medical College Hospital, Beijing, People’s Republic of China. Cardiology Division, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215 State Key Laboratory of Supramolecular Structure and Materials College of Chemistry Jilin University Qianjin Street 2699 Changchun 130012 P. R. China Department of Gastroenterology, Henan Provincial People’s Hospital, Zhengzhou, P. R. China The Key Laboratory of Geriatrics, Beijing Hospital and Beijing Institute of Geriatrics, Ministry of Health, Beijing 100730, China Department of Materials and Environmental Chemistry, Stockholm University, Stockholm, Sweden Institute of Hepatopancreatobiliary Surgery, Southwest Hospital, Third Military Medical University, Chongqing 400038, PR China Institute of Hepatopancreatobiliary Surgery, Southwest Hospital, Third Military Medical University, Chongqing 400038, PR China Division of Infection, Immunity and Respiratory Medicine Manchester University NHS Foundation Trust University of Manchester Manchester UK Rice Research Institute Lianyungang Academy of Agricultural Science Lianyungang China Department of General Surgery, The Third Hospital of Mianyang, Sichuan Mental Health Center, Mianyang, Sichuan 621000, P.R. China Institute of Occupational and Social Medicine, Centre for Health and Society, Faculty of Medicine University of Düsseldorf Düsseldorf Germany Safety Assessment Department, China Institute of Veterinary Drug Control, Beijing 100081, China. Key Laboratory of Geriatrics, Beijing Institute of Geriatrics & Beijing Hospital, Ministry of Health, Beijing, China Suzhou Municipal Center for Disease Prevention and Control Suzhou P. R. China Department of General Surgery, Nanjing Medical University Affiliated Cancer Hospital Cancer Institute of Jiangsu Province, Baiziting 42, Nanjing 210009, China Nanjing University of Posts and Telecommunications; Key Lab of Ministry of Education; National Engineering Research Center Department of Translational Medicine R&D Center Shenzhen Institute of Advanced Technology CAS Guangdong Shenzhen China Department of Chemistry, BioScience Research Collaborative, Rice University, Houston, Texas 77005, United States Department of Hepatopancreatobiliary Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450000, P.R. China 0 Key Laboratory of Bio-based Material Science and Technology of Ministry of Education, Northeast Forestry University, Harbin 150040, P. R. China College of Life Sciences, University of Chinese Academy of Sciences, No. 19A YuQuan Road, Beijing 100049, China Wolfson Department of Chemical Engineering, Technion—Israel Institute of Technology, Haifa 3200003, Israel Johnson & Johnson Pharmaceutical Research & Development, L.L.C., Welsh and McKean Roads, P.O. Box 776, Spring House, Pennsylvania 19477-0776 Department of Biochemistry and Molecular Biology Institute of Basic Medical Sciences, College of Basic Medicine, Hubei University of Medicine Hubei China Key Laboratory of Bio-based Material Science and Technology of Ministry of Education, Material Science and Engineering College Northeast Forestry University Harbin 150040 P.R. China The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei‐MOST) and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology Wuhan University Wuhan China; The Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology Wuhan University Wuhan China Clinical Research Center, Ruijin Hospital Shanghai Jiaotong University School of Medicine Shanghai China Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia Angiogenesis Research Center and Section of Cardiology, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA. School of Emergency Management, School of the Environment and Safety Engineering, Jiangsu University, Zhenjiang 212013, China; State Key Laboratory of Marine Environmental Science, Xiamen University, Xiamen 361102, China Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Melbourne, Australia; Key Laboratory of Bio‐based Material Science and Technology (Ministry of Education) College of Material Science and Engineering Northeast Forestry University Hexing Road 26 Harbin 150040 P. R. China Department of Blood Transfusion, The Third Xiangya Hospital, Central South University, Changsha, China School of Physical Science and Technology ShanghaiTech University 393 Middle Huaxia Road Shanghai 201210 China; Shanghai Clinical Research and Trial Center Shanghai 201210 China State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, 5625 Renmin Street, Changchun 130022, People's Republic of China Department of Fibre and Polymer Technology, KTH Royal Institute of Technology, Teknikringen 56, 10044 Stockholm, Sweden Department of Hepatobiliary Surgery, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, China; Department of the Second Clinical College Shanxi Medical University Taiyuan China Department of Hematology Peking Union Medical College Hospital Peking Union Medical College & Chinese Academy of Medical Sciences Beijing China Graduate Institute of Business Administration, College of Management, Fu Jen Catholic University New Taipei, Taiwan. Regulus Therapeutics, San Diego, CA, USA Department of Urology, The 452 Hospital of Western Air Force, Chengdu, Sichuan 610021, P.R. China State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, People’s Republic of China College of Food Science and Nutritional Engineering, China Agricultural University, China Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, and Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou 215123, China Institut für Biotechnologie and ‡Institut für Chemie, Technische Universität Berlin, D-10623 Berlin, Germany Center for Supramolecular Chemistry and Catalysis Department of Chemistry Shanghai University Shanghai 200444 P. R. China; School of Chemistry and Chemical Engineering Henan Normal University Xinxiang Henan 453007 P. R. China The Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, China. Department of Animal Resource and Science Dankook University Cheonan South Korea; Animal Nutrition Institute Animal Disease‐Resistance Nutrition Key Laboratory of Sichuan Province Sichuan Agricultural University Ya'an China Department of Biochemistry, Stanford University School of Medicine, Stanford, United States Department of Medicinal Chemistry, School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, P. R. China, Department of Chemistry and Chemical Biology, University of New Mexico, Albuquerque, New Mexico 87131-0001, United States, and School of Pharmacy, East China University of Science and Technology, Shanghai 200237, P. R. China 1Department of Endocrinology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, China; 2Translational Medical Center for Stem Cell Therapy & Institute for Regenerative Medicine, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, China Department of Chemistry, Shanghai University, Shanghai 200444, P. R. China, and State Key Laboratory of Molecular Engineering of Polymers and Department of Chemistry, Fudan University, Shanghai 200433, P. R. China Department of Cardiology, The Affiliated Hospital of Qingdao University Center for Fuel Cell Innovation, State Key Laboratory for Coal Combustion, School of Materials Science and Engineering, Huazhong University of Science and Technology, Wuhan, Hubei 430074, China Department of Environmental Health Sciences, Fielding School of Public Health, School of Nursing, University of California, Los Angeles, United States. Electronic address: jianli2019@ucla.edu. State Key Laboratory of Environmental Aquatic Chemistry, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China. Department of Neurosurgery, Linyi People's Hospital, Linyi, Shandong 276003, P.R. China Department of Hematology, Institute of Hematology West China Hospital of Sichuan University Chengdu China Gansu Provincial Center for Disease Control and Prevention, Lanzhou 730000, China. College of Life Science and Technology, Southwest University for Nationalities, Chengdu, China. State Key Laboratory of Drug Research and Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203, China The Key Laboratory of Geriatrics, Beijing Hospital & Beijing Institute of Geriatrics, Ministry of Health, Beijing 100730, China Department of Pharmacy West China Hospital Sichuan University Chengdu 610041 P. R. China Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Melbourne, Australia Laboratory of Immunology and Clinical Genomics Program Molecular Development of the Immune System Section National Institute of Allergy and Infectious Diseases National Institutes of Health Bethesda MD USA; Institute of Immunology Third Military Medical University Chongqing China Department of Bone and Joint Surgery Jining No. 1 People’s Hospital Jining China Frontiers Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering (Ministry of Education), School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville; Monash Biomedicine Discovery Institute, Department of Microbiology, Monash University, Clayton Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, KY 40536, USA Department of Hepatobiliary Surgery, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, Guangdong, China (mainland) Monash Biomedicine Discovery Institute; Department of Microbiology; Monash University; VIC; Australia College of Biological and Agricultural Engineering Jilin University Changchun People's Republic of China College of Veterinary Medicine, Gansu Agricultural University, Lanzhou, Gansu Province, People’s Republic of China Department of Pulmonary Medicine Affiliated Hospital of Jiangsu University Zhenjiang China Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China Institute of Space Sciences (IEEC-CSIC), Campus UAB, Carrer de Magrans s/n, E-08193 Barcelona, Spain. Department of Biomedical Engineering, City University of Hong Kong, Hong Kong 999077, People’s Republic of China; Hong Kong Centre for Cerebro-Cardiovascular Health Engineering, Hong Kong Science Park, New Territories, Hong Kong 999077, People’s Republic of China Cardiovascular Division, Department of Medicine of Beth Israel-Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215 Department of Chemistry & Chemical Biology, McMaster University, Hamilton, ON, Canada L8S 4M1 College of Chemistry and Molecular Engineering, Beijing National Laboratory for Molecular Sciences, Peking University, Beijing 100871, China; Department of Materials and Environmental Chemistry, Stockholm University, Stockholm 10691, Sweden Institute of Qinghai-Tibetan Plateau, Southwest University for Nationalities, Chengdu 610041, China; College of Life Science and Technology, Southwest University for Nationalities, Chengdu 610041, China Key Laboratory of Study and Discovery of Small Targeted Molecules of Hunan Province, School of Medicine, Hunan Normal University , Changsha, China Fujian Key Laboratory of Traditional Chinese Veterinary Medicine and Animal Health; Fujian Agriculture and Forestry University; Fuzhou 350002; China School of Pharmacy, East China University of Science and Technology, Shanghai 200237, People’s Republic of China Department of Pathogen Biology, Hebei Medical University, Shijiazhuang, Hebei, China; Key Laboratory of Immune mechanism and Intervention on Serious Disease in Hebei Province, Shijiazhuang, Hebei, China Environmental Science and Engineering College, Dalian Maritime University, Dalian 116026, China Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry & University of Chinese Academy of Sciences, Chinese Academy of Sciences, Beijing 100190, P. R. China Department of Chemistry, Shanghai University, Shanghai 200444, P. R. China, Department of Chemistry, Fudan University, Shanghai 200433, P. R. China, and Tianjin Institute of Power Source, Tianjin 300381, P. R. China Athinoula A. Martinos Center for Biomedical Imaging , Department of Radiology, , Charlestown, MA, USA; Massachusetts General Hospital , Department of Radiology, , Charlestown, MA, USA; Department of Neurology , , Boston, MA, USA; Massachusetts General Hospital , , Boston, MA, USA Pharmacy, People's Liberation Army Southern Theater General Hospital, Guangzhou 510010, P.R.China. Key Laboratory of Bio-Based Material Science and Technology, Ministry of Education, School of Material Science and Engineering, Northeast Forestry University, Harbin 150040, China Department of Anesthesiology, Shanghai Changzheng Hospital, Second Affiliated Hospital of Naval Medical University , Shanghai 200003 , China Regulus Therapeutics Inc., San Diego, California. Mcnair Technology Co., Ltd; Dongguan 523800; China Department of Rehabilitation Medicine , the First Affiliated Hospital of Nanjing Medical University, Nanjing, China College of Chemistry and Bioengineering; Guilin University of Technology; Guilin; P. R. China Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences Monash University Parkville Melbourne Victoria 3052 Australia The First Department of General Surgery, Affiliated Hospital of Chengde Medical University, Chengde, PR China Biomedicine Discovery Institute, Infection & Immunity Program and Department of Microbiology, Monash University, Clayton Campus, Melbourne, VIC, Australia. colistin.polymyxin@gmail.com. Jiangxi Provincial Key Laboratory of Hemotologic Diseases, Department of Hematology, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China. E-mail: thj127900@163.com. State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry Chinese Academy of Sciences 5625 Renmin Street Changchun 130022 P. R. China; University of Chinese Academy of Sciences Beijing 100049 P. R. China The Key Laboratory of Developmental Genes and Human Disease, Ministry of Education, Institute of Life Sciences Southeast University Nanjing China Department of Neurology II, Affiliated Hospital of Weifang Medical University, Weifang, China State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun 130012, China Drug Delivery; Disposition and Dynamics; Monash Institute of Pharmaceutical Sciences; Monash University; Parkville 3052 Monash Biomedicine Discovery Institute, Infection and Immunity Program and Department of Microbiology, Monash University, Melbourne, VIC, Australia. China Institute of Education Policy, Faculty of Education, Beijing Normal University, Beijing 100875, China College of Materials; Xiamen University; Xiamen; P. R. China State Key Laboratory of Bioreactor Engineering, Shanghai Key Laboratory of New Drug Design, East China University of Science and Technology, Shanghai, China; College of Pharmacy and Chemistry, Dali University, Dali, China 2Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai, China. Department of Neurosurgery, The Affiliated Suqian Hospital of Xuzhou Medical University, Suqian, Jiangsu 223800, P.R. China Monash Institute of Pharmaceutical Sciences, Monash University, Melbourne, Australia Department of Thoracic and Cardiovascular surgery, Nanjing First HospitalNanjing Medical UniversityNanjing Jiangsu China Center for Fuel Cell Innovation School of Materials Science and Engineering Huazhong University of Science and Technology Wuhan 430074 P. R. China Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, United Kingdom; Shanghai Key Laboratory of New Drug Design, School of Pharmacy, and State Key Laboratory of Bioengineering Reactor, East China University of Science and Technology, 130 Mei-long Road, Shanghai 200237, China, and Department of Chemistry and Chemical Biology, University of New Mexico, Albuquerque, New Mexico 87131-0001, United States Department of Chemistry; Shanghai University; Shanghai 200444; P. R. China Department of Oral and Maxillofacial Surgery, The State Key Laboratory Breeding Base of Basic Science of Stomatology & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, No. 237 Luo Yu Road, Wuhan, Hubei 430079, China Biomedicine Discovery Institute and Department of Microbiology, Monash University, Melbourne, VIC, Australia Department of Obstetrics and Gynecology Beijing Shijitan Hospital, Capital Medical University Beijing China Department of Pharmacy, Yuyao People's Hospital of Zhejiang Province, Yuyao, Zhejiang 315400, P.R. China Key Laboratory of Eco-Environment-Related Polymer Materials; Ministry of Education of China; Key Laboratory of Gansu Polymer Materials; College of Chemistry and Chemical Engineering; Northwest Normal University Northwest China Municipal Engineering Northwest Design and Research Institute, Lanzhou 730000, China People’s Liberation Army General Hospital of Western Theater Command, Chengdu, China Sports Medicine Center, West China Hospital, Sichuan University, Department of Orthopedics and Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu, China Key Laboratory of Nuclear Medicine of Ministry of Health, Jiangsu Institute of Nuclear Medicine, Wuxi, Jiangsu 214063, China State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of Ceramics Chinese Academy of Sciences Shanghai 200050 China; Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of Sciences Beijing 100049 China School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, China Department of Pulmonary Medicine, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu, China Molecular Population Genetics Group , Temasek Life Sciences Laboratory, National University of Singapore, 117604 Singapore, Republic of Singapore From the Angiogenesis Research Center, Divisions of Cardiology (J.W., C.P., G.W., P.M.K., R.J.L., J.L.) and Cardiothoracic Surgery (F.W.S.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Mass, and Section of Cardiology, Dartmouth-Hitchcock Medical Center, Dartmouth Medical School, Hanover, NH (M.S.). School of Pharmaceutical Engineering & Life Science; Changzhou University; Changzhou 213164, P. R. China Key Laboratory of Animal Disease‐Resistance Nutrition and Feed Science Ministry of Agriculture Sichuan Agricultural University Chengdu China; Key Laboratory of Animal Disease‐Resistance Nutrition Ministry of Education Sichuan Agricultural University Chengdu China From the Department of Molecular Physiology and Biological Physics (Q.G., T.Y., G.K.O.), University of Virginia, Charlottesville; and Division of Cardiology (J.L.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Mass. Technical Center for Animal, Plant and Food Inspection and Quarantine, Shanghai Entry-Exit Inspection and Quarantine Bureau of China, No. 1208, Minsheng Road, Pudong New Area, Shanghai 200135, China University of Florida Department of Electrical and Computer Engineering, , Gainesville, Florida 32611 State Key Lab of New Drugs and Pharmaceutical Process, Shanghai Institute of Pharmaceutical Industry, Shanghai, China Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037; and Freie Universität Berlin, Institut für Biochemie, Thielallee 63, 14195, Berlin, Germany Center for Reproductive Medicine, Dalian Women and Children's Medical Center (Group), Dalian, China Cardiovascular Medicine, CardioVascular Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Center for Life Science, CLS-909, 3 Blackfan Circle, Boston, MA 02215, USA PET Center and China Institute of Veterinary Drug Control, Beijing 100081, China Department of Environmental Health Sciences, Fielding School of Public Health, School of Nursing, University of California, Los Angeles (UCLA) , CA, USA Blood purification center, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, China Department of Orthopaedics, China Aerospace Science & Industry Corporation Hospital 731, Beijing 100074, China; Department of Orthopedics, The Third Medical Center of PLA General Hospital, Beijing 100039, China Department of Pharmacy, General Hospital of Guangzhou Military Command, Guangzhou 510010, P. R. China Shanghai Key Laboratory of New Drug Design School of Pharmacy East China University of Science and Technology Shanghai China Department of Pediatric Surgery, Shanxi Children's Hospital, Taiyuan 030013, China Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan Institut de Chimie Physique UMR 8000 CNRS Université Paris-Saclay 310 Rue Michel Magat 91400 Orsay France; Laboratory of Renewable Energy Science and Engineering École Polytechnique Fédérale de Lausanne (EPFL) Switzerland State Key Laboratory of Bioorganic and Natural Products Chemistry, Collaborative Innovation Center of Chemistry for Life Sciences, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China Key Laboratory for Animal Disease-Resistant Nutrition of the Ministry of Education of China, Institute of Animal Nutrition, Sichuan Agricultural University, Chengdu 611130, China Orthopedics Department, Yancheng City No. 1 People’s Hospital, Yancheng, P.R. China Aerospace Institute of Advanced Materials & Processing Technology, Beijing 100074, China Department of Hematology Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China The Third Department of General Surgery, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai 519000, China. Department of Neurosurgery, The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China (mainland) School of Automation, Beijing Institute of Technology, Beijing 100081, China. Pediatric Hematology Department, Fujian Institute of Hematology, Fujian Provincial Key Laboratory of Hematology, Fujian Medical University Union Hospital, Fuzhou, Fujian 350001, China. Department of Hematology and Oncology Children's Hospital of Nanjing Medical University Nanjing China University of Chinese Academy of Sciences, Beijing, China. Key Laboratory of Green Chemistry and Technology of Ministry of Education, College of Chemistry, Sichuan University, 29 Wangjiang Road, Chengdu 610064, People’s Republic of China From the The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, China (Hong, Cai, P Li, Liu, Shan, J Li) Key Laboratory of Mesoscopic Chemistry of MOE, College of Chemistry, and Chemical Engineering, Nanjing University, Nanjing 210093, P. R. China, and State Key Laboratory of Elemento-organic Chemistry, Nankai University, Tianjin 300071, P. R. China Department of Gastroenterology Peking University Cancer Hospital & Institute, Key Laboratory of Carcinogenesis and Translational Research Beijing China State Key Laboratory of Food Nutrition and Safety, Key Laboratory of Industrial Fermentation Microbiology of the Ministry of Education, Tianjin Key Laboratory of Industrial Microbiology, College of Biotechnology, Tianjin University of Science and Technology, No. 29 13th Street TEDA, Tianjin 300457, PR China Department of Orthopaedics; The Second Affiliated Hospital of Soochow University; Suzhou 215006; China Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong; Department of Ophthalmology, Affiliated Hangzhou First People’s Hospital, Zhejiang University School of Medicine, Hangzhou, China Jinan Municipal Center for Decease Control and Prevention; Jinan; China College of Pharmacy, Dali University, Dali, Yunnan, China Capital University of Physical Education and Sports, Beijing 100191, China Key Laboratory of Advanced Civil Engineering Materials of Ministry of Education; School of Materials Science and Engineering; and Institute for Advanced Study; Tongji University; Shanghai National Engineering Laboratory for Tree Breeding, Beijing Forestry University, Beijing 100083, China Institute of Electronic Engineering, China Academy of Engineering Physics, Mianyang 621000, China Ministry-of-Education Key Laboratory of Clinical Laboratory Diagnostics, College of Laboratory Medicine, Chongqing Medical University, Chongqing 400016, China. Department of Cardiology, 1st Medical Center, General Hospital of PLA, Beijing 100853, China. Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, Guangdong Province, People’s Republic of China CAS Key Laboratory of Receptor Research CAS Center for Excellence in Molecular Cell Science Shanghai Institute of Materia Medica Chinese Academy of Sciences 555 Zuchongzhi Road Pudong Shanghai 201203 P.R. China; University of Chinese Academy of Sciences No. 19A Yuquan Road Beijing 100049 P.R. China Material Science and Engineering College, Key Laboratory of Bio-based Material Science and Technology, Ministry of Education, Northeast Forestry University, Harbin 150040, China Center for Translational Medicine Research and Development Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences, Shenzhen, Guangdong, China and University of Chinese Academy of Sciences Beijing China Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA Department of Nephrology, Wenling Hospital of Traditional Chinese Medicine, No. 21 Mingyuan Road, Taizhou 317500, China Department of Anesthesiology, Changzheng Hospital, Naval Medical University, 415 Fengyang Road, Shanghai 200003, China Department of Thoracic Surgery, Affiliated Hospital of Zunyi Medical College, Zunyi Medical College, Zunyi, China Department of Radiotherapy Harbin Medical University Cancer Hospital Harbin Heilongjiang China Institute of Molecular Medicine and Experimental Immunology, University Clinic of Rheinische Friedrich-Wilhelms-University, Germany Department of Hematology State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China The Fifth Clinical Medical College of Shanxi Medical University Taiyuan China; Department of Neurosurgery Chanzhi City People's Hospital Chanzhi China Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China Department of Pulmonary Medicine, Affiliated Hospital of Jiangsu University, Zhenjiang - China Peking University Fifth School of Clinical Medicine, The MOH Key Laboratory of Geriatrics, Beijing Hospital, National Center of Gerontology, Beijing, 100730, China Kent State University, Kent, OH, USA Department of Orthopedic Surgery, West China Hospital, Sichuan University, Chengdu, China. Shanghai Institute of Applied Radiation; School of Environmental and Chemical Engineering; Shanghai University; Shanghai 200444; P. R. China Department of Environmental Health Sciences, Fielding School of Public Health, School of Nursing, University of California Los Angeles, Los Angeles, California, USA. Hubei Provincial Key Laboratory of Green Materials for Light Industry, Collaborative Innovation Center of Green Light-weight Materials and Processing, School of Materials Science and Engineering, Hubei University of Technology, Wuhan, PR China Joseph Henry Laboratories and Department of Physics, Princeton University, Princeton, NJ 08544, USA. Jianggan District Center for Disease Control and Prevention, Hangzhou 310004, China. College of Plant Sciences, Jilin University Changchun China Division of Bacteria Diseases, Jinan Municipal Center for Disease Control and Prevention, Jinan, China. Jiangsu Provincial Cancer Hospital, Affiliated to Nanjing Medical University, No. 42 of Baiziting, Nanjing, 210009, China.; Institute of Jiangsu Provincial Cancer Prevention, No. 42 of Baiziting, Nanjing, 210009, China. Center for Fuel Cell Innovation; State Key Laboratory of Material Processing and Die & Mould Technology; School of Materials Science and Engineering; Huazhong University of Science & Technology; Wuhan Department of Neurosurgery, Huadong Hospital, Fudan University, Shanghai, China; Beijing Institution of Radiation Medicine, Beijing 100850, China Department of Medical Environmental Biology and Tropical Medicine, School of Medicine, Kangwon National University, Chuncheon, Gangwon-do, Republic of Korea School of Pharmaceutical Engineering & Life Sciences; Chang Zhou University; Changzhou, P. R. China Engineering Research Center of Advanced Wooden Materials, Ministry of Education, Northeast Forestry University, Hexing Road 26, Harbin 150040, P. R. China; Key Laboratory of Bio-based Material Science & Technology of Ministry of Education, Northeast Forestry University, Hexing Road 26, Harbin 150040, P. R. China Department of Orthopedics, West China Center of Medical Sciences, Sichuan University, Chengdu, Sichuan, China (mainland) Peking University First Hospital, Beijing, China Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing) Department of Gastrointestinal Oncology Peking University Cancer Hospital & Institute Beijing P. R. China Monash Biomedicine Discovery Institute, Department of Microbiology, School of Biomedical Sciences, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Australia Department of Pediatrics the Second Xiangya Hospital Central South University Changsha P.R. China Xinjiang Key Laboratory of Coal Clean Conversion & Chemical Engineering Process, School of Chemical Engineering and Technology, Xinjiang University, Urumqi 830002, China State Key Lab of Analytical Chemistry for Life Science School of Chemistry and Chemical Engineering Nanjing University Nanjing 210023 China The Ministry of Health (MOH) Key Laboratory of GeriatricsBeijing HospitalNational Center of Gerontology BeijingChina Key Laboratory of Hematology, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province,China. E-mail:jeniferjian@gmail.com. Institute of Immunology, PLA, Third Military Medical University, Chongqing, China Center for Molecular and Translational Medicine, Georgia State University, Atlanta (L.Q., C.Y., P.S., J.L., Y.D., M.H.Z.). College of Ocean Food and Biological Engineering, Jimei University Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China xxhh.1986@163.com. Key Laboratory of Energy Thermal Conversion and Control of Ministry of Education, School of Energy and Environment, Southeast University, Nanjing, People’s Republic of China Institute of Materials Research and Engineering, Agency for Science, Technology and Research, 2 Fusionopolis Way, Innovis, #08-03, Singapore 138634, Singapore; Key Laboratory of Brain Science Research and Transformation in Tropical Environment of Hainan Province & Laboratory of Neurology, the First Affiliated Hospital, Hainan Medical University, Haikou 571199, P. R. China; Department of Biochemistry and Molecular Biology and Department of Neurology of the First Affiliated Hospital, Hainan Medical University, Haikou 571199, P. R. China Key Laboratory of Molecular Animal Nutrition of the Ministry of Education and Department of Veterinary Medicine College of Animal Sciences, Zhejiang University Hangzhou People's Republic of China College of Chemistry and Molecular Engineering, Beijing National Laboratory for Molecular Sciences, Peking University, Beijing 100871, China Department of Laboratory Medicine, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, 400042, P.R. China Department of Orthopaedics, Beijing Friendship Hospital, Capital Medical University, Beijing, People’s Republic of China Zhengzhou TCM Traumatology Hospital, Zhengzhou, Henan, China Monash Biomedicine Discovery Institute; Department of Microbiology; Monash University; Clayton; Australia State Key Laboratory of Analytical Chemistry for Life Science School of Chemistry & Chemical Engineering Nanjing University Nanjing 210023 China Facility for Anti-infective Drug Development and Innovation, Department of Pharmacy Practice, Victorian College of Pharmacy, Monash University School of Optoelectronic Science and Engineering; University of Electronic Science and Technology of China; Chengdu; China State Key Laboratory of Environmental Aquatic Chemistry, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, P.O. Box 2871 Beijing 100085, China 1Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China. Uropath Pty Ltd Perth Western Australia Australia Clinical Research Center, Ruijin Hospital Department of Blood Transfusion The Third Xiangya Hospital Central South University Changsha 410013 China State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, Fujian, People's Republic of China Department of Orthopedics The Second Affiliated Hospital of Soochow University Jiangsu Suzhou China Keck Center for Molecular Imaging, Morehouse School of Medicine, Atlanta, GA, USA Sports Medicine Center of Orthopaedics, West China Hospital, Sichuan University, Chengdu Sichuan, 610041, P.R.China. Key Laboratory of Industrial Fermentation Microbiology of the Ministry of Education, State Key Laboratory of Food Nutrition and Safety, College of Biotechnology, Tianjin University of Science and Technology, Tianjin 300457, China. School of Forensic Medicine, Shanxi Medical University, 98 University Street, Yuci District, Jinzhong 030604, China Stomatological Center of Suzhou Municipal Hospital Suzhou Hospital Affiliated to Nanjing Medical University Suzhou China Facility for Anti-Infective Drug Development and Innovation, Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Melbourne, Victoria 3052, Australia Key Laboratory of Qinghai‐Tibetan Plateau Animal Genetic Resource Reservation and Exploitation of Ministry of Education Southwest Minzu University Chengdu 610041 China; Key Laboratory of Animal Science of State Ethnic Affairs Commission Southwest Minzu University Chengdu 610041 China; College of Animal and Verterinary Sciences Southwest Minzu University Chengdu 610041 China Department of Urban and Environmental Science, Peking University, Beijing 100871, China, CN Department of Ultrasonography, Binzhou Hospital of Traditional Chinese Medicine, Binzhou 256601, Shandong, China Jun Li, Affiliated Hospital/Clinical Medical College of Chengdu University, Chengdu, and Zhongshan Hospital, Fudan University Colorectal Cancer Research Center, Shanghai, People’s Republic of China; and Jian Li, Chengdu University School of Medicine, Chengdu, People’s Republic of China State Key Laboratory of Mariculture Biobreeding and Sustainable Goods, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao 266071, China; Laboratory for Marine Fisheries Science and Food Production Processes, Laoshan Laboratory, Qingdao 266237, China The Key Laboratory of Geriatrics, Beijing Hospital, National Center of Gerontology, National Health Commission, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences Shenzhen Key Laboratory for Orchid Conservation and Utilization, The National Orchid Conservation Center of China and the Orchid Conservation & Research Center of Shenzhen, Shenzhen 518114, China; Key Laboratory of National Forestry and Grassland Administration for Orchid Conservation and Utilization, The National Orchid Conservation Center of China and the Orchid Conservation & Research Center of Shenzhen, Shenzhen 518114, China The School of Electrical Engineering Chongqing University 174 Shazheng Street, Shapingba District Chongqing City 400044 P. R. China From the Departments of Ophthalmology and Department of pulmonary Medicine, Affiliated Hospital of Jiangsu University, Zhenjiang - China Department of Orthopedics, The Hospital 731 China Aerospace Science and Industry Group Beijing China College of Food and Biological Engineering, Jimei University, Xiamen 361021, P. R. China; Fujian Provincial Engineering Technology Research Center of Marine Functional Food, Xiamen 361021, P. R. China Shanghai Institute of Applied Physics, Chinese Academy of Sciences, 239 Zhangheng Road, Shanghai 201204, China Key Laboratory of Bio-based Material Science and Technology; Ministry of Education; Northeast Forestry University; Harbin 150040; China National Key Laboratory of Mariculture Biobreeding and Sustainable Goods, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao 266071, China; Function Laboratory for Marine Fisheries Science and Food Production Processes, Qingdao National Laboratory for Marine Science and Technology, Qingdao 266071, China Key Laboratory for Animal Disease-Resistant Nutrition of the Ministry of Education of China, and Animal Nutrition Institute, Sichuan Agricultural University , Wenjiang, Chengdu 611130 , People’s Republic of China Department of Thoracic Surgery Peking University First Hospital Beijing China Hunan Province Key Laboratory for Antibody-Based Drug and Intelligent Delivery System, School of Pharmaceutical Sciences, Hunan University of Medicine, Huaihua 418000, China The Key Laboratory of Geriatrics Beijing Institute of Geriatrics Beijing Hospital, National Center of Gerontology National Health Commission; Institute of Geriatric Medicine Chinese Academy of Medical Sciences Beijing China; Graduate School of Peking Union Medical College Beijing China Centre for Pharmaceutical Research and School of Pharmaceutical, Molecular and Biomedical Sciences, University of South Australia, Adelaide, Australia. Regulus Therapeutics, San Diego, CA 92121, USA. University of Science and Technology of China, 230026 Hefei, Anhui, China. College of Science Shanghai University Shanghai 200444 P. R. China Department of Blood Transfusion, The Third Xiangya Hospital, Central South University, Changsha 410013, P. R. China Key Laboratory for Animal Disease-Resistant Nutrition of the Ministry of Education of China, Animal Nutrition Institute, Sichuan Agricultural University, Chengdu, Sichuan, P. R. China Key Laboratory of Organic Optoelectronics & Molecular Engineering, Department of Chemistry, Tsinghua University, Beijing 100084, China Department of Clinical Medicine, Medical College of Hunan Normal University, Changsha 410006, China. E-mail: 13656355@qq.com. Nanjing University of Posts and Telecommunications; Broadband Wireless Communication and Sensor Network Technology, Key Lab of Ministry of Education; Telecommunication and Networks, National Engineering Research Center State Key Laboratory of Genetic Engineering, Department of Microbiology and Microbial Engineering, School of Life Sciences, Fudan University, 2005 Songhu Road, Shanghai 200438, China Affiliated Hospital of Guizhou Medical University, Guiyang, China College of Ocean Food and Biological Engineering, Jimei University , Xiamen 361021, China College of Bioscience and Biotechnology, Hunan Agriculture University, Changsha, Hunan 410128, China Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases of Ministry of Education, Gannan Medical University, Ganzhou, China; Department of Ophthalmology, The Affiliated Changshu Hospital of Xuzhou Medical University, Changshu, China Orthopaedic Research Institution, Department of Orthopaedics, West China Hospital, Sichuan University, Chengdu, China. Department of Blood Transfusion, The Third Xiangya Hospital, Central South University, Changsha 410013, Hunan, P. R. China Department of Interventional Radiology, The Affiliated Hospital of Qingdao University, Qingdao, 266011, China School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, P. R. China Endoscopy Center, Endoscopy Research Institute, Zhongshan Hospital, Fudan University, Shanghai 200032, China Department of Thoracic Surgical Oncology, Cancer Institute (Hospital), Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100021, China. Department of Gastrointestinal Oncology, Key laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Peking University Cancer Hospital and Institute, Beijing, China Shandong Hi-Speed Group Co., Ltd., Jinan 250098, China Key Laboratory of Fertility Preservation and Maintenance of Ministry of Education , Yinchuan , China; School of Basic Medical Sciences , Yinchuan , China; Ningxia Medical University , Yinchuan , China Department of Geriatric Endocrinology, Chinese PLA General Hospital, No. 28 Fuxing Road, Beijing 100853, China Institute of Chinese Material Medica, Academy of Chinese Medical Sciences, Beijing, 100700, China. State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China; Department of Reproductive Medicine, Peking University Shenzhen Hospital, Shenzhen Peking University-The Hong Kong University of Science and Technology Medical Center, Shenzhen, China College of Pharmaceutical Sciences, Gannan Medical University, Ganzhou 341000, P. R. China School of Materials Science and Engineering, State Key Lab of Material Processing and Die & Mould Technology, Huazhong University of Science and Technology, Wuhan 430074, China State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering Nanjing University Nanjing 210023 P. R. China Prenatal Diagnostic Center Guangzhou Women and Children’s Medical Center affiliated with Guangzhou Medical University Guangzhou China Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850, China. Graduate School of Peking Union Medical College Chinese Academy of Medical Sciences Beijing China; The Key Laboratory of Geriatrics Beijing Institute of Geriatrics and Beijing Hospital Ministry of Health Beijing China Center for Bioinformatics & Genomics, Department of Biostatistics & Bioinformatics, School of Public Health & Tropical Medicine, Tulane University, New Orleans, LA 70112, USA.; School of Medicine, University of Missouri-Kansas City, Kansas City, MO 64108, USA Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Institute of Animal Nutrition, Sichuan Agricultural University, Chengdu, Sichuan, People’s Republic of China Institute of Molecular Medicine and Experimental Immunology University Clinic of Rheinische Friedrich‐Wilhelms‐University Bonn Germany Laboratory of Environmental Biotechnology Jiangsu Engineering Laboratory for Biomass Energy and Carbon Reduction Technology Jiangsu Key Laboratory of Anaerobic Biotechnology School of Environmental and Civil Engineering Jiangnan University Wuxi 214122 P. R. China Monash Biomedicine Discovery Institute, Department of Microbiology, Monash University, Parkville, Victoria 3800, Australia College of Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China. Department of Pharmacy General Hospital of Southern Theater Command Guangzhou Guangdong China Department of Gastrointestinal Oncology, Laboratory of Carcinogenesis and Translational Research of the Ministry of Education, Peking University School of Oncology, Beijing Cancer Hospital & Institute , Beijing , People’s Republic of China Clinical Research Center, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China. Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104; Chinese Academy of Sciences; University of Chinese Academy of Sciences MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, P.R. China Beijing Institute of Radiation Medicine, Beijng, 100850, China Department of Hematology, The Affiliated Drum Tower Hospital of Medical School of Nanjing University Nanjing, 210008, PR China. Department of Hematology, Fujian Institute of Hematology, Fujian Provincial Key Laboratory on Hematology, Fujian Medical University Union Hospital, Fuzhou 350001, Fujian, P. R. China Department of General Surgery, Henan Cancer Hospital, Zhengzhou, China. Sports Medicine Center, West China Hospital, Sichuan University, Chengdu, PR China; Department of Orthopedics and Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu, PR China Suzhou Municipal Center for Disease Prevention and Control, Suzhou 215004, China State Key Laboratory for Physical Chemistry of Solid Surfaces, Department of Chemical Biology, College of Chemistry and Chemical Engineering, the Key Laboratory for Chemical Biology of Fujian Province, The MOE Key Laboratory of Spectrochemical Analysis & Instrumentation, and Innovation Center for Cell Signaling Network, Xiamen University, Xiamen 361005, China Department of Urology, The People’s Hospital of Jinhu, Huaian 211600, Jiangsu Province, China Key Laboratory of Hematology, The Second Affiliated Hospital of Nanchang University,Nanchang 330006, Jiangxi Province, China,E-mail: ndefy03048@ncu.edu.cn. Prenatal Diagnostic Center, Guangzhou Women and Children Medical Center, Guangzhou Medical University, Guangzhou, People’s Republic of China Facility for Anti-infective Drug Development and Innovation Hepatobiliary and Enteric Surgery Research Center Xiangya Hospital Central South University Changsha Hunan China Department of Hemotology Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences Beijing 100730 China Biology Department of Xuzhou Normal University, Xuzhou 221 116, China. lijianbest@sohu.com Department of Veterinary Medicine, College of Animal Sciences, Zhejiang University, No. 866 Yuhangtang Road, Hangzhou 310058, China Department of Endocrinology and Metabolism, First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, China; Department of Endocrinology and Metabolism, First People’s Hospital of Xinxiang City, Xinxiang, Henan Province, China Department of Orthopaedic Surgery, Orthopaedic Research Institute, West China Hospital, Sichuan University, Chengdu 610064, China College of Mining Engineering, Taiyuan University of Technology, Taiyuan 030024, China Centre for Pharmaceutical Research, School of Pharmaceutical, Molecular and Biomedical Sciences, University of South Australia, Adelaide, Australia. Department of Otolaryngology, The First Affiliated Hospital, Sun-Yat-sen University, Guangzhou, China College of Chemistry and Molecular Engineering, Peking University, Yiheyuan Road 5, Beijing 100871, China Key Laboratory of Bio-based Material Science and Technology of Ministry of Education, Northeast Forestry University, Hexing Road 26, Harbin 150040, P.R. China Biomedicine Discovery Institute and Department of Microbiology, Monash University, Victoria, Melbourne, Australia Key laboratory of Bio-based Material Science and Technology; Ministry of Education; Northeast Forestry University; Harbin 150040; P. R. China Institute of Municipal Engineering, Zhejiang University, 866 Yuhangtang Road, Hangzhou 310058, China Westlake Institute for Advanced Study Hangzhou 310012 China Department of Pediatric Orthopaedics and Department of Radiology Tianjin Hospital, Tianjin University Tianjin 300211 China Division of Rheumatology, Inflammation and Immunity, Brigham and Women’s Hospital, Boston, Massachusetts;; Harvard Medical School, Harvard University, Boston, Massachusetts; and Department of Orthopedics, Orthopedic Research Institute, West China Hospital Sichuan University Sichuan P. R. China College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, P. R. China; Department of Materials and Environmental Chemistry, Stockholm University, Stockholm 10691, Sweden Chinese PLA General Hospital; Beijing 100853; P. R. China Key Laboratory for Sustainable Utilization of Marine Fisheries Resources, Ministry of Agriculture and Rural, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao 266071, China; Function Laboratory for Marine Fisheries Science and Food Production Processes, Qingdao National Laboratory for Marine Science and Technology, Qingdao 266237, China Key Laboratory of Cell Proliferation and Differentiation of the Ministry of Education, College of Life Sciences, Peking University, Beijing; Department of Hematology, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College Department of Cell Biology and Genetics, College of Life Sciences, Peking University, Beijing 100871, People's Republic of China Department of Obstetrics, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, P.R. China Department of Pharmacy Taikang Xianlin Drum Tower Hospital Nanjing Jiangsu China Department of Nuclear Medicine, The Third Xiangya Hospital of Central South University, Changsha, Hunan 410013, P.R. China Department of Cardiovascular, Xi’an Children’s Hospital, Xi’an 710003, China Jiangsu Province Key Laboratory of Anesthesiology, Jiangsu Province Key Laboratory of Anesthesia and Analgesia Application Technology, NMPA Key Laboratory for Research and Evaluation of Narcotic and Psychotropic Drugs, Xuzhou Medical University, Xuzhou, Jiangsu, China Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences Monash University Parkville Victoria 3052 Australia Clinical Laboratory Center, Children’s Hospital of Fudan University, Shanghai, PR China; Shanghai Key Laboratory of Birth Defect, Children’s Hospital of Fudan University, Shanghai, PR China Department of Hematology, Peking Union Medical College Hospital, CAMS and PUMC, Beijing 100730, China. Department of Cardiology, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University, People’s Republic of China From the Cardiovascular Research Center (D.S., S.S., J.D.R., R.E.G.) and Center for Immunology and Inflammatory Diseases (D.S., T.J.T.A., S.S., A.Y.L., R.E.G.), Massachusetts General Hospital, Boston, MA; the Division of Cardiovascular Medicine and University of Pennsylvania Cardiovascular Institute, Philadelphia, PA (J.L., L.C., M.S.P.); Metabolic Pathways Center of Excellence for Drug Discovery, GlaxoSmithKline, King of Prussia, PA (J.J.L.); the Division of Endocrinology and Metabolism, University... State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China 2Institute of Pediatrics, Children's Hospital of Fudan University, and the Shanghai Key Laboratory of Medical Epigenetics, Institutes of Biomedical Sciences, Shanghai Medical College of Fudan University, Shanghai, China. Department of Rehabilitation, Dagang Oil Field General Hospital of Tianjin, Tianjin 300280, China. College of Life Science and Technology, Southwest Minzu University, Chengdu, China. Hunan Key Laboratory of Cancer Metabolism Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University Changsha Hunan China; University of South China Changsha Hunan China School of Biotechnology and Health Sciences, Wuyi University, Jiangmen, Guangdong 529090, China Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences Number 106 Nanjing Road Qingdao 266071 People's Republic of China Department of Otolaryngology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510655, Guangdong, China Faculty of Human Body Morphology, School of Basic Medical Sciences, Beijing University of Chinese Medicine, Beijing 100029, China. Department of Laboratory Medicine, Xiangya School of Medicine, Central South University, Changsha 410008, P.R. China Department of Endocrinology, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150081, P.R. China School of Public Health and Tropical Medicine, Tulane University, New Orleans, Louisiana, USA Drug Delivery, Disposition and Dynamics; Monash Institute of Pharmaceutical Sciences; Monash University; Parkville Victoria Australia Department of Hematology Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China Department of Thoracic Surgery, The First Hospital of Qinhuangdao, Qinhuangdao, Hebei 066000, P.R. China Department of Hematology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences Beijing 100730, China. Department of Gastrointestinal Oncology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital & Institute, Beijing, People’s Republic of China Key Laboratory of Study and Discovery of Small Targeted Molecules of Hunan Province, School of Medicine, Hunan Normal University, Changsha, China 2 The Scripps Research Institute, 10666 North Torrey Pines Road, La Jolla, CA 92037, USA Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 201203, P. R. China, and School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China Department of Gynecologic Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China Beijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Technology and Business University, NO. 33 Fucheng Road, Beijing, 100048, China Department of Otolaryngology the First Affiliated Hospital of Sun Yat‐sen University Guangzhou Guangdong 510080 China Clinical Research Center, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China State Key Laboratory of Power Transmission Equipment and System Security Chongqing University 174 Shazheng Street Shapingba District Chongqing City 400044 P. R. China Department of Chemistry Shanghai University Shanghai 200444 P. R. China Department of Biological Engineering, College of Environment and Chemistry Engineering, Yanshan University, Qinhuangdao 066004, China; College of Animal Science and Technology, Northwest A&F University, Yangling 712100, China; College of Basic Medicine, Jiamusi University, Jiamusi 154007, China Key Laboratory of Animal Diseases Diagnostic and Immunology, Ministry of Agriculture, MOE International Joint Collaborative Research Laboratory for Animal Health & Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China Division of Biology Chemistry and Materials Science, Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, Office of Medical Products and Tobacco, U.S. Food and Drug Administration Silver Spring Maryland 20993 Department of Orthopedics, Orthopedic Research Institute, West China Hospital, Sichuan University State Key Laboratory of Severe Weather, Chinese Academy of Meteorological Sciences, China From the Divisions of Cardiothoracic Surgery (P.V., C.B., T.A.K., S.-H.X., J.F., A.R., T.M., Y.N., F.W.S.) and Cardiology (J.L.), Beth Israel Deaconess Medical Center, Boston, Mass, and the Division of Cardiac Surgery (M.R.), University of Ottawa Heart Institute, Ottawa, Ontario, Canada. Prenatal Diagnostic Center, Guangzhou Women and Children’s Medical Center affiliated to Guangzhou Medical University, Guangzhou, Guangdong, People’s Republic of China; Department of Neurosurgery, Tianjin Medical University General Hospital, China (Y.Y., B.W., C.P., Y.Z., J.L., J.Z., X.Y.). Department of Molecular Medicine and Surgery; Karolinska University Hospital; Karolinska Institutet; Stockholm Sweden b Beijing Institute of Radiation Medicine , Beijing , 100850 , China Key Laboratory for Animal Disease Resistance Nutrition of the Ministry of Education of China Animal Nutrition Institute Sichuan Agricultural University Chengdu China Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Institute of Animal Nutrition, Sichuan Agricultural University, Wenjiang District, Chengdu, Sichuan, People’s Republic of China MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou 510631, China; Joint Laboratory of Laser Oncology with Cancer Center of Sun Yet-sen University, South China Normal University, Guangzhou 510631, China Shenzhen Engineering Research Center for Medical Bioactive Materials, Center for Translational Medicine Research & Development, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong 518055, China; University of Chinese Academy of Sciences, Beijing 100049, China Cuiying Biomedical Research Center Lanzhou University Second Hospital, Lanzhou University Lanzhou China State Key Laboratory of Food Nutrition and Safety Key Laboratory of Industrial Fermentation Microbiology of the Ministry of Education Tianjin Key Laboratory of Industrial Microbiology College of Biotechnology Tianjin University of Science and Technology No. 29 the 13th Street TEDA Tianjin 300457 China Department of Chemistry, Center for Supramolecular and Catalytic Chemistry, Shanghai University, Shanghai 200444, P. R. China Department of Biostatistics & Data Science Tulane School of Public Health and Tropical Medicine New Orleans Louisiana USA Department of Pediatrics Union Hospital of Fujian Medical University Fuzhou China Beijing Institute of Geriatrics, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China School of Public Health, Kunming Medical University China; Department of Medical Sociology University of Duesseldorf Germany Department of Neurology, Affiliated Hospital of Weifang Medical University, Weifang, Shandong, China. The Key Laboratory of Hematology of Jiangxi Province, The Department of Hematology, The Second Affiliated Hospital of Nanchang University, Nanchang, People’s Republic of China; Graduate School of Medicine, Nanchang University, Nanchang, People’s Republic of China China Academy of Chinese Medical Sciences, Beijing 100070. Department of Nuclear Medicine, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia School of Pharmacy; East China University of Science and Technology; Shanghai 200237; P. R. China Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education Wuhan University School of Pharmaceutical Sciences Wuhan University Wuhan 430071 Hubei P. R. China School of Chemistry and Pharmaceutical Sciences State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources Guangxi Normal University Guilin 541004 P. R. China School of Basic Medical Sciences, Hubei University of Medicine, Shiyan, China Department of Orthopedics (Minimally Invasive Spine Surgery Branch), Beijing Haidian Hospital (Haidian Section of Peking University Third Hospital), ZhongGuanCun Street 29#, Hai-Dian District, Beijing, China Department of Polymer Science and Engineering, CAS Key Laboratory of Soft Matter Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, China Wound Care Unit, Nanjing Drum Tower Hospital, Nanjing, PR China. Prenatal Diagnostic Center Guangzhou Women and Children Medical Center Guangzhou China Department of Molecular Biology TPC-15, The Scripps Research Institute, La Jolla, California 92037 College of Plant Sciences Jilin University Changchun 130062 China National Engineering Research Center of Seafood, School of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, P.R. China Department of Neurosurgery, Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, P.R. China Key Laboratory of Bio‐based Material Science and Technology of Ministry of Education Northeast Forestry University Harbin 150040 China Clinical Laboratory Center, Children’s Hospital of Fudan University, Shanghai 201102, China Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology Chinese Academy of Sciences Beijing China State Key Laboratory of Oncology in Southern China, Sun Yat-Sen University Cancer Center, Guangzhou, China; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China Department of Laboratory Medicine, Xiangya School of Medicine, Changsha 410013; Medical Research Center, Xiangya Hospital, Central South University, Changsha 410008, China. Department of Microbiology, Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences and Biomedicine Discovery Institute Monash University Parkville Victoria Australia School of Basic Medical Sciences, Chengdu University, Chengdu, People’s Republic of China College of Economics and Management, Beijing University of Technology, Beijing 100124, China *Morphotek, Inc., 210 Welsh Pool Road, Exton, PA 19341; Infection and Immunity Program Monash Biomedicine Discovery Institute and Department of Microbiology Monash University Clayton Victoria 3800 Australia Department of Radiation Oncology, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang, China Technical Center for Animal, Plant and Food Inspection and Quarantine, Shanghai Customs District, Shanghai 200135, P. R. China Sports Medicine Center, Department of Orthopedic Surgery/ Orthopedic Research Institute, West China Hospital, Sichuan University Department of Orthopedics, Jinan Fourth People's Hospital, Jinan, Shandong 250031, P.R. China Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 Duality Biologics, Ltd , Shanghai, P.R. China Key Laboratory of Neutron Physics and Institute of Nuclear Physics and Chemistry, China Academy of Engineering Physics (CAEP) 3 , Mianyang 621999, China Monash Institute of Pharmaceutical Sciences, Monash University, Parkville Victoria, Australia. School of Chinese Materia Medica, Nanjing University of Chinese Medicine, 138 Xianlin Avenue, Nanjing 210023, China; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203, China Department of Orthopedics, The Airborne Troops Hospital of Chinese PLA, Wuhan, China Department of Pharmacy, West China Hospital Sichuan University Chengdu Sichuan China Department of Otolaryngology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou Key Laboratory of Otorhinolaryngology, Otorhinolaryngology Institute of Sun Yat-sen University, Guangzhou 510080, China Department of Clinical Laboratory, The People's Hospital of Dongtai City, Dongtai 224200, PR China Department of Chemistry; Shanghai University; Shanghai; P. R. China Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, United States Department of Orthopaedic Surgery, Orthopaedic Research Institute, West China Hospital, Sichuan University State Key Laboratory of Traction Power, Southwest Jiaotong University, Chengdu 610031, China Key Laboratory of Bio-based Material Science and Technology of Ministry of Education, Northeast Forestry University, Harbin 150040, China Shanghai Center for Disease Control and Prevention, Shanghai 200336, China. National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China. Biomedicine Discovery Institute, Department of Microbiology, Monash University, Melbourne 3800, Australia Department of Sports Medicine, Fuzhou Second Hospital, Fuzhou, China AnHui Province Key Laboratory of Chemistry for Inorganic/Organic Hybrid Functionalized Materials, Anhui University, Hefei 230601, P. R. China Key Lab of Organic Optoelectronics and Molecular Engineering; Department of Chemistry; Tsinghua University; 100084 Beijing, China College of Chemistry and Molecular Engineering Beijing National Laboratory for Molecular Sciences Peking University Beijing 100871 China; Department of Materials and Environmental Chemistry Stockholm University 10691 Stockholm Sweden Key Laboratory of Molecular Medicine, Ministry of Education, Fudan University, 200032 Shanghai, China; Beihang University The Scripps Research Institute, La Jolla California 92037, and Texas Biotechnology Corporation, Houston Texas 77030 College of Food and Biological Engineering, Jimei University, No. 43 Yindou Road, Jimei District, Xiamen, Fujian 361021, P. R. China; Fujian Marine Functional Food Engineering Technology Research Center, Xiamen, Fujian 361021, P. R. China Department of Physics and Electronic Engineering; Heze University; Heze 274015; China Department of Environmental Health Sciences, Fielding School of Public Health, School of Nursing, University of California, Los Angeles, USA Monash Biomedicine Discovery Institute, Department of Microbiology, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne 3800, Australia Department of Biological Engineering, College of Environment and Chemical Engineering, Yanshan University, Qinhuangdao, PR China. Department of Dermatology, Huashan Hospital Affiliated to Fudan University, Shanghai 200040, China Key Laboratory of Animal Disease-Resistance Nutrition and Feed Science, Ministry of Agriculture, Sichuan Agricultural University, 211 Huimin Road, Wenjiang District, Chengdu, Sichuan 611130, China; Key Laboratory of Animal Disease-Resistance Nutrition, Ministry of Education, Wenjiang, China Department of Pediatric Hematology, Fujian Institute of Hematology, Fujian Provincial Key Laboratory of Hematology, Fujian Medical University Union Hospital, Fuzhou 350001, Fujian Province, China,E-mail: 1354113723@qq.com. Department of Reproductive Medicine, Beijing Obstetrics and Gynecology Hospital, The Capital University of Medical Science, Beijing, People's Republic of China. Department of Chemical Biology, College of Chemistry and Chemical Engineering, State Key Laboratory for Physical Chemistry of Solid Surfaces, the Key Laboratory for Chemical Biology of Fujian Province, The MOE Key Laboratory of Spectrochemical Analysis & Instrumentation, and Innovation Center for Cell Signaling Network, Xiamen University, Xiamen, 361005, China Department of Geriatric Endocrinology, Chinese PLA General Hospital, National Clinical Center of Geriatric Medicine, Beijing, China Email: lijian02@hotmail.com. Department of Dermatology, Southwest Hospital, Army Medical University, Chongqing, China Department of Architecture and Industrial Design, Università degli Studi della Campania “Luigi Vanvitelli,” Aversa CE 81031, Italy Signal and Image Processing Institute University of Southern California Los Angeles California School of Psychological and Cognitive Sciences, Peking University, Beijing 100871, China;; Beijing Key Laboratory of Behavior and Mental Health, Peking University, Beijing 100871, China;; IDG/McGovern Institute for Brain Research, Peking University, Beijing 100871 China; Department of Radiology, First Affiliated Hospital of Nanchang University; Clinical Research Center For Medical Imaging In Jiangxi Province, Nanchang, China College of Environmental and Chemical Engineering, Yanshan University, Qinhuangdao, Hebei Province 066004, China Department of Anesthesiology, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei China; Department of Anesthesiology Shenzhen Second People's Hospital Guangdong Province Shenzhen China Key Laboratory for Animal Disease Resistance Nutrition of the Ministry of Education, Animal Nutrition Institute, Sichuan Agricultural University, 211 Huimin Road, No. 6 Teaching Building, Room 604, Wenjiang District, Chengdu, Sichuan 611130, China School of Physics, Department of Materials Physics, Northwest University, Xi’an 710069, China Department of Orthopaedics, the First Affiliated Hospital of University of South China, Hengyang 421001, Hunan, China. Department of Orthopaedics the Second Affiliated Hospital of Soochow University Suzhou China; Osteoporosis Institute of Soochow University Suzhou China Animal Nutrition Institute, Sichuan Agricultural University, Chengdu, Sichuan 611130, China; Key Laboratory of Animal Disease-Resistant Nutrition of Ministry of Education, Sichuan Agricultural University, Chengdu, Sichuan 611130, China Department of General Medicine, The People's Hospital of Shinan, Qingdao 266002, P. R. China Laboratory of Renewable Energy Science and Engineering, Institute of Mechanical Engineering EPFL, Station 9, 1015 Lausanne, Switzerland Clinical Laboratory Center Children's Hospital of Fudan University Shanghai 201102 China Human Neuroimaging Laboratory, Department of Neuroscience Department of Fibre and Polymer Technology, KTH Royal Institute of Technology, Teknikringen 56, Stockholm10044, Sweden Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, 312 Anshanxi Road, Nankai District, Tianjin 300193, China Department of Anatomy Chengdu Medical College Chengdu Sichuan China Institute of Neuroinformatics and Laboratory for Body and Mind, Dalian University of Technology, Dalian 116024, China; Key Laboratory for Sustainable Utilization of Marine Fisheries Resources Ministry of Agriculture and Rural Affairs Yellow Sea Fisheries Research Institute Chinese Academy of Fishery Sciences Qingdao China; Function Laboratory for Marine Fisheries Science and Food Production Processes Qingdao National Laboratory for Marine Science and Technology Qingdao China Department of Radiology, Jining No. 1 People’s Hospital, Jining, Shandong, China; Department of Radiology, Jining No. 1 People’s Hospital, Jining, Shandong, China Root Biology Center, Fujian Agriculture and Forestry University, Fuzhou 350002, China State Key Laboratory of Physical Chemistry of Solid Surfaces Key Laboratory of Chemical Biology of Fujian Province Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province (IKKEM), and College of Chemistry and Chemical Engineering Xiamen University Xiamen 361005 China Family Planning Department, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China School of Materials, Arizona State University, Tempe, Arizona 85287, United States College of Life Sciences Hunan Normal University Changsha 410081 China State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China Orthopedic Department West China Hospital, Sichuan University Chengdu China Institute of Occupational and Social Medicine University of Dusseldorf Dusseldorf Germany Department of Geriatric Endocrinology, Chinese PLA General Hospital, Beijing, China. Key Laboratory of Bio-based Material Science and Technology of Ministry of Education, Northeast Forestry University, Harbin, 150040, People’s Republic of China Department of Anesthesiology, General Hospital of Civil Aviation Administration of China, Beijing, China. lijian780315@163.com Sports Medicine Center, West China Hospital, Sichuan University, Chengdu, China; Department of Orthopedics and Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu, China Key Laboratory of Model Animals and Stem Cell Biology in Hunan Province, School of Medicine, Hunan Normal University, Hunan, China; Key Laboratory of Study and Discovery of Small Targeted Molecules of Hunan Province, School of Medicine, Hunan Normal University, Hunan, China. Department of Pharmaceutical Science, School of Pharmacy, East China University of Science & Technology, Shanghai 200237, People’s Republic of China, and Department of Chemistry and Chemical Biology, University of New Mexico, Albuqueruqe, New Mexico 87131-0001, United States A. A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School. Center for Neurotechnology and Neurorecovery, Department of Neurology, Massachusetts General Hospital and Harvard Medical School. Key Laboratory of Precision Opto-Mechatronics Technology, Ministry of Education, School of Instrumentation Science and Opto-Electronics Engineering, Beihang University, 37 Xueyuan Rd., Haidian District, Beijing 100191, China Department of Environmental Health Sciences, Fielding School of Public Health, University of California Los Angeles State Key Laboratory of Stem Cell and Reproductive Biology Institute of Zoology Chinese Academy of Sciences Beijing China; University of Chinese Academy of Sciences Beijing China Facility for Anti-Infective Drug Development and Innovation; Drug Delivery, Disposition and Dynamics; and Medicinal Chemistry and Drug Action, Monash Institute of Pharmaceutical Sciences, Parkville, Melbourne, Victoria 3052, Australia, and School of Medicine, Deakin University, Pigdons Road, Geelong 3127 Victoria, Australia Department of Radiotherapy the Second Affiliated Hospital of Guangxi Medical University Nanning People's Republic of China Department of Surgery–Otorhinolaryngology Head and Neck Surgery, the Queen Elizabeth Hospital, and the University of Adelaide, Adelaide, South Australia, Australia; and Department of Neurology, JiangYuan Hospital Affiliated to Jiangsu Institute of Nuclear Medicine, Wuxi, Jiangsu 214063, China Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China Department of Prenatal Diagnostic Center; Guangzhou Women and Children's Medical Centre; Guangzhou Medical University; Guangzhou Guangdong China Department of Chemistry Capital Normal University Beijing P. R. China Department of Chemistry; Key Lab of Organic Optoelectronics & Molecular Engineering; Tsinghua University; Beijing 100084, P. R. China Frontiers Science Center of Synthetic Biology and Key Laboratory of Systems Bioengineering (Ministry of Education), School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China Key Laboratory of Qinghai‐Tibetan Plateau Animal Genetic Resource Reservation and Exploitation of Ministry of Education Southwest Minzu University Chengdu China; Key Laboratory for Animal Science of National Ethnic Affairs Commission Southwest Minzu University Chengdu China Wound Care Center, Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School, Nanjing, Jiangsu, China Department of Radiation Oncology, The Second Affiliated Hospital of Guangxi Medical University, Nanning, China State Key Laboratory of Natural and Biomimetic Drugs Peking University Beijing 100191 China Neurology Department, Affiliated Hospital of Weifang Medical University, Shandong, China (J.L.) Institute of Robotics, Beihang University, Beijing, China. Department of Cardiology, the First Medical Center, Chinese PLA General Hospital, Beijing, China Division of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138; and Departments of Electrical Engineering and Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139 College of Chemistry, Chemical Engineering and Environmental Engineering; Liaoning Shihua University; Fushun 113001; China Clinical Research Center in Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200025, China State Key Laboratory for Conservation and Utilization of Bio‐Resources in Yunnan Yunnan Agricultural University Kunming China Department of Hematology, Chinese Academy of Medical Sciences and Peking Union Medical College Hospital, Beijing, China. Laojunshan National Nature Reserve Sichuan Province Pingshan China State Key Laboratory of Food Nutrition and Safety, Key Laboratory of Industrial Fermentation Microbiology of the Ministry of Education Tianjin Key Laboratory of Industrial Microbiology Tianjin Engineering Research Center of Microbial Metabolism and Fermentation Process Control College of Biotechnology Tianjin University of Science and Technology Tianjin China Center for Eukaryotic Gene Regulation, Department of Biochemistry and Molecular Biology, Pennsylvania State University, 465A North Frear Laboratory, University Park, PA, 16802, USA. Biomedicine Discovery Institute; Infection & Immunity Program and Department of Microbiology; Monash University; Melbourne 3800; Australia College of Chemistry and Molecular Engineering Peking University 5 Yiheyuan Road Beijing 100871 P. R. China School of Medicine, University of Missouri–Kansas City, Kansas City, MO, USA Industrial Enzymes National Engineering Laboratory, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, 300308 Tianjin, China Department of Cardiology, Huashan Hospital Fudan University 12 Middle Urumqi Road Shanghai 200040 China Department of Urology Luzhou People's Hospital Luzhou China The Key Laboratory of Hematology of Jiangxi Province, The Department of Hematology, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China MOH Key Laboratory of Geriatrics, Beijing Hospital, National Center of Gerontology, 100730 Beijing, People’s Republic of China; College of Sciences and Institute of Pesticide, Northwest A&F University, Yangling, Shaanxi 712100, China Endoscopy Center, Minhang Hospital Fudan University Shanghai China College of Forestry Northwest A&F University No. 3 Taicheng Road Yangling Shaanxi 712100 P. R. China Monash Biomedicine Discovery Institute, Infection Program and Department of Microbiology, Monash University, Melbourne, VIC 3800, Australia Department of Clinical Laboratory Sun Yat‐Sen Memorial Hospital, Sun Yat‐Sen University Guanzhou Guangdong Province People's Republic of China Department of Anesthesiology Neuroscience Research Centre Changzheng Hospital Second Military Medical University Shanghai China Animal Nutrition Institute of Sichuan Agricultural University Ya'an Sichuan China Key Laboratory of Hematology , The Second Affiliated Hospital of Nanchang University; Jiangxi Province,China. E-mail:ndefy03048@ncu.edu.cn. Department of Hematology, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing 100730, China. E-mail: pumch.li.jian@gmail.com. Department of Pathogenic Biology Hebei Medical University Shijiazhuang PR China Department of Rheumatology and Immunology, Affiliated Hospital of Jining Medical University, Jining, Shandong 272000, P.R. China School of Medicine Chengdu University Chengdu China; Institute of Cancer Biology and Drug Discovery Chengdu University Chengdu China Department of Medicinal Chemistry, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China Department of Anesthesiology, Affiliated Hospital of Zunyi Medical University, Zunyi, China; Department of Computer Science and Technology, Changchun University of Science and Technology, Changchun, Jilin, China Animal Nutrition Institute, and Animal Disease‐Resistance Nutrition Key Laboratory of Sichuan Province Sichuan Agricultural University Ya'an China School of Food and Health Beijing Engineering and Technology Research Center of Food Additives, Beijing Advanced Innovation Center for Food Nutrition and Human Health, , Beijing Technology and Business University (BTBU), Beijing, 100048, China Clinical Laboratory Center; Children's Hospital of Fudan University; Shanghai 201102; China From the Cardiovascular Institute, Beth Israel Deaconess Medical Center, Boston, MA (L.X.L., F.D.); Corrigan Minehan Heart Center, Massachusetts General Hospital, Boston (L.X.L., F.D., M.C.C., S.D., A.R.); Division of Cardiovascular Disease, University of Alabama at Birmingham (G.C.R.); Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia (S.Y., J.L., S.W., M.M., Z.A.); Lewis-Sigler Institute for Integrative Genomics, Princeton University, NJ (W.L., C.J., J... Section of Orthopaedics, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden The Fifth Clinical Hospital of Peking University, Health Science Center, Beijing 100730, China; Key Laboratory of Geriatrics, Beijing Hospital, Beijing Institute of Geriatrics, Ministry of Health of China, Beijing 100730, China Key Laboratory of Bio-based Material Science and Technology, Ministry of Education, Northeast Forestry University, Harbin 150040, China College of Horticulture Shenyang Agricultural University Shenyang 110866 Liaoning Province China Department of Pediatric Hematology, Fujian Provincial Institute of Hematology, Fujian Provincial Key Laboratory of Hematology, Fujian Medical University Union Hospital, Fuzhou 350001, Fujian Provincial, China,E-mail:1354113723@qq.com. Departments of Chemistry, Pharmacology, and Preclinical Toxicology, Texas Biotechnology Corporation, 7000 Fannin, Suite 1920, Houston, Texas 77030 Department of Basic Medicine, Medical College of Hunan Normal University, Changsha, China Department of Electrical and Computer Engineering, University of Florida, Gainesville, Florida 32611 State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, 5625 Renmin Street, Changchun 130022, P. R. China WuXi AppTec Company, Ltd., Shanghai 200131, P. R. China Key Laboratory of Combinatorial Biosynthesis and Drug Discovery; Ministry of Education; Wuhan University School of Pharmaceutical Sciences; Wuhan University; Wuhan Drug Delivery, Disposition and Dynamics, ‡Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville 3052, Victoria, Australia University of Southern California, Department of Chemistry, Los Angeles, California 90089, and Division of Chemistry and Chemical Engineering, Arnold and Mabel Beckman Laboratories of Chemical Synthesis, California Institute of Technology, Pasadena, California 91125 Key Laboratory of Sustainable Development of Marine Fisheries Key Laboratory of Maricultural Organism Disease Control Ministry of Agriculture Yellow Sea Fisheries Research Institute Chinese Academy of Fishery Sciences Qingdao China; Laboratory for Marine Fisheries Science and Food Production Processes Qingdao National Laboratory for Marine Science and Technology Qingdao China State Key Laboratory of Biocontrol, Guangdong Provincial Key Laboratory of Plant Resources, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, P. R. China State Key Laboratory of Biocontrol Guangdong Key Laboratory of Plant Resource School of Life Sciences Sun Yat‐sen University Guangzhou 510275 China Department of Hematology,PUMC Hospital,CAMS and PUMC,Beijing 100730,China. Department of Orthopaedics Orthopaedic Research Institution, West China Hospital, Sichuan University Chengdu China Medical Research Center of Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong, P. R. China Department of Chemistry, Innovative Drug Research Center, and ‡Shanghai Key Laboratory of High Temperature Superconductors, Shanghai University, Shanghai 200444, People’s Republic of China Monash Biomedicine Discovery Institute, Department of Microbiology Monash University Clayton Victoria Australia Rehabilitation Hospital affiliated to Fujian University of Traditional Chinese Medicine, Fuzhou, China; Fujian Key Laboratory of Rehabilitation Technology, Fujian University of Traditional Chinese Medicine, Fuzhou, China Ministry of Education Key Laboratory for the Green Preparation and Application of Functional Materials, Hubei University, Wuhan 430062, China; State Key Laboratory of Solid Lubrication, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China State Key Laboratory of Analytical Chemistry for Life Sciences, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China Department of Thoracic Surgery, West China Hospital, Sichuan University, Chengdu, China Department of Hematology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China. Institute of Environmental Health and Ecological Security, School of the Environment and Safety Engineering, Jiangsu University, Zhenjiang 212013, China College of Life Science and Technology Southwest Minzu University Chengdu China 1Institute for Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilians-Universität München, Munich, Germany.; 2German Cancer Consortium (DKTK), Heidelberg, Germany.; 3German Cancer Research Center (DKFZ), Heidelberg, Germany. Domestic Discovery Service Unit, WuXi AppTec (Shanghai) Co. Ltd., 288 FuteZhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131, China Department of Cardiology, The Affiliated Hospital of Qingdao University, Qingdao, China Department of Reproductive Medicine, Peking University Shenzhen Hospital, Shenzhen Peking University-The Hong Kong University of Science and Technology Medical Center, Shenzhen, China; State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China Institute of Occupational, Social and Environmental Medicine, Centre for Health and Society, Faculty of Medicine (J.L.) and Life Science Centre, University of Düsseldorf, Germany; Fielding School of Public Health, School of Nursing, University of California, Los Angeles (J.L.) Department of Oral and Maxillofacial Surgery The State Key Laboratory Breeding Base of Basic Science of Stomatology & Key Laboratory of Oral Biomedicine Ministry of Education School & Hospital of Stomatology Wuhan University Wuhan China College of Ocean Food and Biological Engineering, Jimei University, Xiamen, Fujian, China; Fujian Marine Functional Food Engineering Technology Research Center, Xiamen, Fujian, China Shanghai Municipal Center for Disease Control and Prevention, Shanghai 200336, China. From the Division of Cardiothoracic Surgery (S.M., B.R., M.B., R.T.C., S.-H.X., C.B., J.L., F.W.S.) and Transplantation (K.M., T.M.), Beth Israel Deaconess Medical Center, Boston, Mass. College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China Shanghai Key Laboratory of New Drug Design School of Pharmacy East China University of Science and Technology 130 Meilong Road Shanghai 200237 China Department of Microbiology, Monash Biomedicine Discovery Institute, Monash University, Melbourne, Australia; Department of Orthopedic, Maanshan People's Hospital, Ma’anshan City, China. College of Food and Biological Engineering, Jimei University, Xiamen 361021, China; Fujian Provincial Engineering Technology Research Center of Marine Functional Food, Xiamen 361021, China Department of Pharmaceutical Engineering, College of Life Science and Biotechnology, Heilongjiang August First Land Reclamation University, Daqing High-Tech Industrial Development Zone, 163319, P. R. China.; School of Animal Science, Northwest A & F University, 22 Xinong Street, Yangling 712100, P. R. China.; Department of Biological Engineering, School of Environment and Chemistry Engineering, Yanshan University, 438 Hebei Street, Qinhuangdao 066004, P. R. China.; School of Basic Medical Sciences, Jiamusi University, Jiamusi City, Heilongjiang Province, 154007, P. R. China. School of Basic Medical Sciences, Hubei University of Medicine, Shiyan, Hubei 442000, China College of Fisheries, Huazhong Agricultural University Freshwater Aquaculture Collaborative Innovation Center of Hubei Province Wuhan 430070 China Xi’an Modern Chemistry Research Institute Stanford Genome Technology Center, Stanford University, Palo Alto, California 94304, United States School of Pharmacy, East China University of Science and Technology, 130 Mei Long Road, Shanghai 200237, China Department of Nephrology The Second Hospital of Jilin University 218 ZiQiang Street Changchun Jilin 130000 China Department of General Surgery 3, The Fifth Affiliated Hospital of Sun Yat‑sen University, Zhuhai, Guangdong 519000, P.R. China Prenatal Diagnostic Center, Guangzhou Women and Children’s Medical Center affiliated to Guangzhou Medical University, Guangzhou, Guangdong Province, People’s Republic of China Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia.; School of Stomatology, Wuhan University, Wuhan, China. Janssen, R&D, LLC, A Division of Johnson & Johnson R&D, LLC, 145 King of Prussia Road, Radnor, PA 19087, USA Chongqing Key Laboratory of Inorganic Special Functional Materials; College of Chemistry and Chemical Engineering; Yangtze Normal University; Fuling 408100; China College of Animal Science and Technology, Northwest A&F University, Yangling 712100, China Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305 Department of Chemistry and Key Lab of Organic Optoelectronics & Molecular Engineering; Tsinghua University; Beijing; P. R. China Beijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Technology & Business University, Beijing 100048, China Department of Chemical and Biological Engineering Northwestern University Evanston Illinois 60208 Ministry of Education Key Laboratory for Cross-Scale Micro and Nano Manufacturing, Changchun University of Science and Technology, Changchun 130022, China Central Laboratory , Kunming Institute of Zoology, Chinese Academy of Sciences , Kunming , Yunnan 650223, P. R. China Department of General Surgery Xiangya Hospital, Central South University Changsha China Infection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Microbiology, Monash University, Victoria, Australia Beijing Key Laboratory of Rehabilitation Technical Aids for Old-Age Disability, Key Laboratory of Neuro-functional Information and Rehabilitation Engineering of the Ministry of Civil Affairs, National Research Center for Rehabilitation Technical Aids, Beijing, P. R. China Department of Hematology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of China; Department of Safety Engineering, University of Wuppertal, Wuppertal, Germany. lijian1974@hotmail.com Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Shatin, Hong Kong, China; Department of Thoracic and Cardiovascular Surgery Huanggang Central Hospital of Yangtze University Huanggang China School of Pharmacy, Nantong University, Nantong, China Department of Thoracic Surgery, Anyang Tumor Hospital, Anyang, Henan 455000, P.R. China Department of Acute Infectious Disease, Shanghai Municipal Center for Disease Control and Prevention, China. Department of Cardiology, Huashan Hospital, Fudan University, Shanghai, People’s Republic of China Department of Psychology and Beijing Key Laboratory of Behavior and Mental Health Peking University Beijing 100871 China; PKU‐IDG/McGovern Institute for Brain Research, Peking University Beijing 100871 China Department of Gastrointestinal Medical Oncology, Beijing University School of Oncology, Beijing 100036, China. College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, P. R. China Department of Cardiac Diseases, Huashan Hospital, Fudan University, Shanghai. lijian3@medmail.com.cn Center for Fuel Cell Innovation, School of Materials Science and Engineering, State Key Lab of Material Processing and Die & Mould Technology, Huazhong University of Science and Technology, Wuhan 430074, China Facility for Anti-infective Drug Development and Innovation, Victorian College of Pharmacy, Monash University, Victoria 3052, Australia Department of Orthopedics, Shangrao People's Hospital, Shangrao, Jiangxi 334000, P.R. China Centre for Pharmaceutical Research, University of South Australia, Adelaide,1 and Departments of General Surgery, the 5th Affiliated Hospital, Sun Yat-sen University, Zhuhai, Guangdong 519000, China. Department of Nuclear Medicine, Xiangya Hospital Central South University Changsha Hunan China Xi An Modern Chemistry Research Institute College of Chemistry; Key Laboratory for Radiation Physics and Technology of Ministry of Education; Analytical & Testing Center; Sichuan University; Chengdu 610064 Department of Head and Neck Surgery, Cancer Centre of Sun Yat‑sen University, Guangzhou, Guangdong 510060, P.R. China Neuroscience Center, General Hospital of Ningxia Medical University, Key Laboratory of Craniocerebral Diseases of Ningxia Hui Autonomous Region, Yinchuan, China Key Laboratory of Bio-based Material Science and Technology of Ministry of Education Northeast Forestry University Harbin 150040 P. R. China University of Chinese Academy of Sciences 19A Yuquan Road Beijing 100049 China; State Key Laboratory of Bio-organic and Natural Products Chemistry Center for Excellence in Molecular Synthesis Shanghai Institute of Organic Chemistry Chinese Academy of Sciences Shanghai 200032 China Facility for Drug Development and Innovation, Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia; Monash Biomedicine Discovery Institute, Department of Microbiology, Monash University, Clayton, Victoria 3800, Australia China Institute of Education and Social Development, Beijing Normal University, Beijing, China Faculty of Traditional Chinese Medicine, Naval Medical University (Second Military Medical University), Shanghai, China. Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia; Monash Biomedicine Discovery Institute, Department of Microbiology, Monash University, Clayton, Victoria, Australia School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA Department of Cardiology Tianjin Institute of Cardiology Tianjin Key Laboratory of Ionic‐Molecular Functions in Cardiovascular Diseases Second Hospital of Tianjin Medical University Tianjin China Department of Chemistry, Innovative Drug Research Center, Shanghai University, Shanghai 200444, P. R. China Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education of China), Department of GI Oncology, Peking University Cancer Hospital and Institute, Beijing, China. Infection and Immunity Program, Biomedicine Discovery Institute and Department of Microbiology, 19 Innovation Walk, Monash University, Clayton, VIC, 3800, Australia. Electronic address: jian.li@monash.edu. WuXi AppTec (Shanghai) Co., Ltd., 288 FuTe Zhong Road, Shanghai 200131, People’s Republic of China Department of GI Oncology, Peking University Cancer Hospital, Beijing 100142, China. oncogene@163.com. College of Chemistry and Molecular Engineering Peking University Beijing 100871 P. R. China Centre for Pharmaceutical Research Center for Photon Manufacturing Science and Technology, Zhenjiang, P. R. China 212013 Department of Pharmacy Practice, Centre for Medicine Use and Safety, Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia; Facility for Anti-infective Drug Development and Innovation (FADDI), Monash Institute of Pharmaceutical Sciences, Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia WuXi AppTec, 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131, P. R. China Department of General Surgery, Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research & Nanjing Medical University Affiliated Cancer Hospital, Nanjing 210009, China Department of Psychology, Peking University; IDG/McGovern Institute for Brain Research, Peking University College of Pharmaceutical Sciences, Ganan Medical University, Ganzhou, Jiangxi 341000, People’s Republic of China Department of Biostatistics and Bioinformatics, School of Public Health and Tropical Medicine, Tulane University, New Orleans, US Department of Geriatric Endocrinology, Chinese PLA General Hospital, China Shaanxi Key Laboratory of Low Metamorphic Coal Clean Utilization, School of Chemistry and Chemical Engineering, Yulin University, Yulin, 719000, PR China Department of Hematology, PUMC Hospital, CAMS and PUMC, Beijing 100730, China. Joseph Henry Laboratories and Department of Physics, Princeton University, Princeton, NJ 08544, USA.; Institute for Natural Sciences, Westlake Institute for Advanced Study, Hangzhou, Zhejiang, China.; Westlake University, Hangzhou, Zhejiang, China. 1Department of Gastrointestinal Oncology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital and Institute, Beijing, China. |
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