http://rdf.ncbi.nlm.nih.gov/pubchem/author/MD5_04377722b69619ab144ffcce7660f6ce
Outgoing Links
| Predicate | Object |
|---|---|
| family-name | Chen Xi Chen |
| name | Xi Chen |
| given-name | Xi |
| organization-name | College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, Hubei, People’s Republic of China Department of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee, USA Department of Neurosurgery Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China Department of Chemistry, University of California-Davis, Davis, CA, USA Department of Immunology School of Basic Medical Sciences Fudan University Shanghai China; Biotherapy Research Centre and Institute of Immunobiology Fudan University Shanghai China The Second People's Hospital of Yibin, Yibin, Sichuan, China Department of Statistics,; Bio-X Program, and Key Laboratory of Environment and Health, Ministry of Education State Key Laboratory of Environment Health (Incubation) Key Laboratory of Environment and Health (Wuhan), Ministry of Environmental Protection School of Public Health, Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China Department of Pharmacology School of Basic Medicine Tongji Medical College Huazhong University of Science and Technology Wuhan City China Department of Urology, Tongji Hospital, School of Medicine Tongji University Shanghai China Department of Chemistry University of California‐Davis Davis California School of Materials Science and Engineering, Wuhan University of Technology, Wuhan, Hubei 430070, China Department of Epidemiology, Faculty of Navy Medicine, Second Military Medical University, Shanghai, China Key Laboratory of Functional Polymer Materials, Ministry of Education, Institute of Polymer Chemistry, Nankai University, Tianjin 300071, China Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health, School of Public Health Tongji Medical College, Huazhong University of Science and Technology Wuhan Hubei China The Second Xiangya Hospital, Central South University Changsha Hunan China Department of Rehabilitation Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China Department of Ophthalmology, Duke University, Durham, North Carolina, United States Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou City, P. R. China Department of Ophthalmology, The Affiliated Hospital of Medical College of Ningbo University, Jiangbei, Ningbo, Zhejiang 315020, P.R. China Department of Chemical and Biomolecular Engineering, The University of Melbourne, Parkville, Victoria 3010, Australia The Hunan Institute of Pharmacy Practice and Clinical Research, Xiangya Hospital, Central South University, Changsha 410008, China; Department of Pharmacy, Xiangya Hospital, Central South University, Changsha 410008, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410008, China Institute of Biochemistry, College of Life Sciences and Medicine Zhejiang Sci‐Tech University Hangzhou Zhejiang Province China; Zhejiang Provincial Key Laboratory of Silkworm Bioreactor and Biomedicine Hangzhou Zhejiang Province China Intensive Care Unit The First People's Hospital of Chongqing Liang Jiang New Area Chongqing China Graduate University of Chinese Academy of Sciences, Beijing 100049, China. chenxi20080808@gmail.com Shandong Center for Disease Control and Prevention Jinan China Department of Orthopaedic Surgery, Center for Cancer Research and Cell Biology, Queen's University Belfast, Belfast, United Kingdom Department of Rehabilitation Medicine, The First Affiliated Hospital, Sun Yat-Sen University , Guangzhou , China College of Horticulture, Nanjing Agricultural University, Nanjing 210095, China Ministry of Education, Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310006, China Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China Biomedical Imaging Research Institute (P.A.M., F.C., X.C., M.G., A.R., D.D.), Cedars-Sinai Medical Center, Los Angeles, CA. Department of Chemistry, ‡Department of Molecular and Cellular Biology, and §Cell Biology Graduate Program, University of California, One Shields Avenue, Davis, California 95616, United States Department of Chemistry, University of California, Davis, Davis, CA 95616 5 Department of Oncology, Fuzhou General Hospital of Nanjing Military Command, Fuzhou, Fujian 350025, P.R. China ORIC Pharmaceuticals, 240 E. Grand Avenue, Fl2, South San Francisco, California 94080, United States Xiamen University Department of Physics, Fujian Key Laboratory of Plasma and Magnetic Resonance, State Key Laboratory of Physical Chemistry of Solid Surfaces, , Xiamen 361005, People’s Republic of China Department of Chemistry, University of Manchester, Manchester M13 9PL, U.K. Department of Biology and Centre for Advanced Research in Environmental Genomics Department of Genetics, Development and Cell Biology, Iowa State University, Ames, IA 50011, USA Nanchang Business College of Jiangxi Agricultural University, Jiujiang, Jiangxi 332020, China Chemical Biology Research Center, School of Pharmaceutical Science Wenzhou Medical University Wenzhou Zhejiang 325035 China Columbia Nanomechanics Research Center, Department of Earth and Environmental Engineering, Columbia University, New York, New York 10027, United States; School of Aerospace, Xi’an Jiaotong University, Xi’an 710049, China; Department of Civil & Environmental Engineering, Hanyang University, Seoul, 133-791, Korea Department of Orthopedic Surgery, West China Hospital, West China School of Medicine, Sichuan University , Chengdu 610041, China State Key Laboratory of Silkworm Genome Biology, Biotechnology Research Center Southwest University Chongqing 400716 China Division of Plant Sciences University of Missouri Columbia Missouri School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798, Singapore Department of Ophthalmology, Duke University, Durham, North Carolina State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, China Departments of Chemistry and Physics, Nanoscience Center, University of Jyväskylä, 40014 Jyväskylä, Finland School of Chemistry and Chemical Engineering, Southeast University, Jiangsu Optoelectronic Functional Materials and Engineering Laboratory, Nanjing 211189, China Department of Chemistry and Biochemistry, Center for Systems and Synthetic Biology, University of Texas at Austin, Austin, TX 78712 Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy Xuzhou Medical University Xuzhou 221004 Jiangsu China College of Environmental Science and Engineering, Taiyuan University of Technology, Taiyuan, China Minnesota Dental Research Center for Biomaterials and Biomechanics (MDRCBB); University of Minnesota; Minneapolis; USA College of Biosystems Engineering and Food Science Zhejiang University Hangzhou China Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China Beijing Key Laboratory of TCM Foundation and New Drug Research, School of Chinese Material Medica, Beijing University of Chinese Medicine, Beijing 100102, China Department of radiotherapy, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, Tianjin’s Clinical Research Center for Cancer, Tianjin, China Basic Science Center Project of National Natural Science Foundation of China Key Laboratory for Ultrafine Materials of Ministry of Education and School of Materials Science and Engineering East China University of Science and Technology Shanghai 200237 P. R. China State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-Sen University Cancer Center, Guangzhou 510060, China; Department of Nasopharyngeal Carcinoma, Sun Yat-Sen University Cancer Center, Guangzhou 510060, China Henan Key Laboratory of Child Brain Injury and Henan Pediatric Clinical Research Center, Third Affiliated Hospital and Institute of Neuroscience of Zhengzhou University, Zhengzhou, China Chemical Genomics Centre of the Max-Planck Society Dortmund Germany Department of Neurosurgery, Huashan Hospital Fudan University Shanghai China Shanghai Minhang Center for Disease Control and Prevention, Shanghai, People's Republic of China. Department of General Surgery, The Second Affiliated Hospital of Medical College Key Laboratory of Luminescent and Real-Time Analytical System (Southwest University), Chongqing Science and Technology Bureau, College of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, P. R. China Department of Chemistry, University of California‐Davis Davis California Chengdu Second Peoples Hospital, Chengdu 610017, P.R. China Beth Israel Deaconess Medical Center, Division of Endocrinology, Diabetes, and Metabolism, and Harvard Medical School, Boston, MA 02215, USA. Department of Abdominal Cancer, Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, China. Genentech San Francisco California USA Key Laboratory of Environmentally Friendly Chemistry and Application of Ministry of Education, Key Laboratory for Green Organic Synthesis and Application of Hunan Province, College of Chemistry, Xiangtan University, 411105 Xiangtan, China State Key Laboratory and Institute of Elemento-Organic Chemistry, Frontiers Science Center for New Organic Matter, College of Chemistry, Nankai University, Tianjin 300071, China Department of Radiology, Huashan Hospital Fudan University Shanghai China Department of Molecular Biology and Biochemistry, Simon Fraser University, 8888 University Drive, Burnaby, BC V5A 1S6, Canada College of Mechanical Engineering, Hunan Institute of Science and Technology, Yueyang 414006, China Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People’s Republic of China Department of Civil, Environmental, and Architectural Engineering, University of Colorado Boulder, Boulder, Colorado 80309, United States Beijing Key Laboratory of Drug Resistance Tuberculosis Research, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing Chest Hospital, Capital Medical University, Beijing, China State Key Laboratory of Marine Environmental Science Xiamen University Xiamen China Department of Mechanical Engineering, IUPUI, 723 W Michigan st, 46202, Indianapolis, IN, USA; Department of Mechanical Engineering, Purdue Universiy, 47907, West Lafayette, IN, USA SpecAlly Life Technology Co., Ltd., Wuhan 430030, China a College of Natural Resources and Environment, South China Agricultural University, Guangzhou 510642, China; b College of Marine Sciences, South China Agricultural University, Guangzhou 510642, China Department of Otorhinolaryngology, The First Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu, 210029, PR China Department of Orthopedic Surgery, Peking Union Medical College Hospital, Peking Union Medical College Chinese Academy of Medical Science Beijing China Department of Ophthalmology, Daping Hospital, Army Medical Center of PLA, Army Medical University, Chongqing, China Science and Technology on Electronic Test and Measurement Laboratory; North University of China; Taiyuan; China College of Plant Protection, China Agricultural University, No. 2 Yuanmingyuan West Road, 100193Beijing, China Zhejiang Provincial People’s Hospital Hangzhou China Department of Preventive and Pediatric Dentistry, Ninth People's Hospital, College of Stomatology, School of Medicine, Shaughai Jiao Tong University, Shanghai 200011, China. Pi-Wei Institute, Guangzhou University of Chinese Medicine , Guangzhou, China; Science and Technology Innovation Center, Guangzhou University of Chinese Medicine , Guangzhou, China State Key Laboratory of Herbage Improvement and Grassland Agro-ecosystems, Center for Grassland Microbiome, College of Pastoral Agriculture Science and Technology, Lanzhou University, Lanzhou 730000, China Columbia University 4 Department of Earth & Environmental Engineering, , New York, New York 10027, USA Department of Thoracic Surgery, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China Hunan Provincial Center for Disease Control and Prevention, Changsha 410005, China. BNLMS, Peking-Tsinghua Center for Life Sciences at College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China; Center for Quantitative Biology, Academy of Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China From the Department of Human Population Genetics, Institute of Molecular Medicine, Peking University, Beijing, PR China (K.X., Y.L., G.Y.Z., X.L.T.); Department of Physiology and Pathophysiology, School of Basic Medical Sciences (L.M., H.L.) and Department of Cardiology, Beijing Chaoyang Hospital (F.J.), Capital Medical University, Beijing, PR China; State Key Laboratory of Cardiovascular Diseases (F.W., X.C.) and Department of Cardiology (A.D.), Fuwai Hospital and Cardiovascular Institute, Chinese... Eye Hospital of Wenzhou Medical University, Wenzhou, China Department of Dermatology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu 221002, China Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA; Division of Biostatistics, Department of Public Health Science, University of Miami Miller School of Medicine, Miami, FL, USA Departments of Pathology, Surgery, Physiology, and Medicine, Columbia University, College of Physicians and Surgeons, New York, NY 10032; Haldeman Laboratory for Alzheimer’s Disease Research, Sun Health Research Institute, Sun City, AZ 85372; National Neurological Research Specimen Bank, West Los Angeles Veterans Administration Medical Center, 17301 Wilshire Boulevard, Los Angeles, CA 90073; and University of California, Los Angeles, School of Medicine, Harbor–University of California, Los Angeles,... College of Informatics, Huazhong Agricultural University, Wuhan, 430070 China. Contribution from the Department of Physics and Division of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts 02138, Lehrstuhl fuer Biophysik − E22, Technische Universitaet Muenchen, Germany, Los Alamos National Laboratory, Chemistry Division, Los Alamos, New Mexico 87545, and The Nanotechnology Lab, Kraft Foods R&D, 801 Waukegan Road, Glenview, Illinois 60025 Department of Electronic Science and Technology, University of Science and Technology of China, Hefei 230027, Anhui, China College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, People’s Republic of China Materials Science and Engineering Program Texas Materials Institute The University of Texas at Austin Austin TX 78712 USA Department of Neurology, Affiliated Hospital of BeiHua University , Jilin , 132011 China Department of Pharmacology, Beijing Key Laboratory of Drug Resistance Tuberculosis Research, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing, China Department of Chemistry, University of California, Davis, California, USA. School of Pharmacy, Nanjing Medical University, Nanjing 211166, China General Hospital of Ningxia Medical University, China Department of Hematology The Second Affiliated Hospital Harbin Medical University Harbin China State Key Laboratory of Hybrid Rice College of Life Sciences Wuhan University Wuhan 430072 China Syngenta Biotechnology, Research Triangle Park, North Carolina 27709 National Engineering Laboratory for Industrial Enzymes and Tianjin Engineering Research Center of Biocatalytic Technology, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, 32 West Seventh Avenue, Tianjin Airport Economic Area, Tianjin 300308, China Department of Applied Physics, Aalto University, Otakaari 1, FI-02150 Espoo, Finland Authors' Affiliations: Departments of 1Biochemistry and Molecular Genetics, 2Pharmacology and Toxicology, and 3Pathology, The University of Alabama at Birmingham; 4Drug Discovery Division, Southern Research Institute, Birmingham; 5Drug Discovery Research Center, Mitchell Cancer Institute, University of South Alabama, Mobile; 6Department of Biology, Chemistry and Mathematics, University of Montevallo, Montevallo; 7Department of Pharmaceutical Chemistry, The German University in Cairo, Cairo, Egypt; 8INCELL, San Antonio, Texas; and 9Cancer Prevention and Control Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States Engineering Research Center for Functional Ceramics of the Ministry of Education, School of Optical and Electronic Information, Huazhong University of Science and Technology, Wuhan 430074, PR China State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences—Wuhan National Laboratory for Optoelectronics 1 , Wuhan 430071, China National Institute of Environmental Health, Chinese Center for Disease Control and Prevention (China CDC), Beijing 102206, China. Syngenta Biotechnology, Inc., Research Triangle Park, North Carolina 27709 (X.C., T.Z.) Beijing Key Laboratory of Drug Target Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences, & Peking Union Medical College, Beijing 100050, China Department of Orthopedic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China Henan Key Laboratory of Child Brain Injury Third Affiliated Hospital and Institute of Neuroscience Zhengzhou University Zhengzhou 450052 China Department of Chemistry and the MOE Key Laboratory of Spectrochemical Analysis and Instrumentation, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, Fujian 361005, China; State Key Laboratory of Marine Environmental Science, Xiamen University, Xiamen, Fujian 361005, China Department of Materials Science and Engineering, University of Wisconsin-Milwaukee; Milwaukee; USA Department of Biological Sciences, National University of Singapore, 117543 Singapore Department of Periodontology, School and Hospital of Stomatology, Jilin University, Changchun 130021, P. R. China Department of Preventive and Community Dentistry College of Dentistry University of Iowa Iowa City Iowa USA Department of Chemistry, University of California, One Shields Avenue, Davis, California 95616, United States *Institute for Immunobiology, Shanghai Medical College of Fudan University, Shanghai 200032, China; Department of Chemistry University of California Davis California Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, China Department of Earth and Environmental Engineering Columbia University 905E Mudd, 500 West 120th Street New York NY 10027 USA *Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892; State Key Laboratory of Explosion Science and Technology, Beijing Institute of Technology, Beijing, China; Jiangsu Engineering Research Center for microRNA Biology and Biotechnology State Key Laboratory of Pharmaceutical, Biotechnology School of Life Sciences Nanjing University Nanjing China School of Chemistry and Chemical Engineering; Harbin Institute of Technology; Harbin; P. R. China Department of Dermatology Affiliated Hospital of Xuzhou Medical University Xuzhou China Beijing Stomatological Hospital Capital Medical University Beijing China State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat‑sen University, Guangzhou, Guangdong 510060, P.R. China Key Laboratory for Large-Format Battery Materials and System, Ministry of Education, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan 430074, China Laboratory of Biomedical Microsystems and Nano Devices; Bionic Sensing and Intelligence Center; Institute of Biomedical and Health Engineering; Shenzhen Institutes of Advanced Technology; Chinese Academy of Sciences From the Department of Epidemiology and Biostatistics, Cancer Center; and Departments of Oncology and Thoracic Surgery, First Affiliated Hospital of Nanjing Medical University, Nanjing Medical University; State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University; and the Department of Thoracic Surgery, Jiangsu Cancer Hospital, Nanjing, China. The School of Artificial Intelligence and Automation, Huazhong University of Science and Technology, Wuhan 430074, China; Image Processing and Intelligent Control Key Laboratory of Education Ministry of China, Huazhong University of Science and Technology, Wuhan 430074, China Department of Biological Sciences, Columbia University, New York, New York 10027 Ministry of Education Key Laboratory of Environment and Health (J.W., Y.Lin, Y.Li, J.C., L.S., Z.Z., Z.L., W.X., X.C., S.X.), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China Institute of Integrated Agricultural Development Research, Guizhou Academy of Agricultural Sciences, Guiyang, China. School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin, Heilongjiang 150090, P. R. China; School of Life Sciences, Huzhou University, Huzhou, Zhejiang 313000, P. R. China Department of Rehabilitation Medicine , The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, China Faculty of Medicine, Beihua University, Jilin, Jilin 132013, P.R. China Department of Allergy and Clinical Immunology, Guangzhou Institute of Respiratory Health, State Key Laboratory of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China; Department of Clinical Laboratory, Guangzhou Panyu Central Hospital, Guangzhou, China Chemical Biology Research Center School of Pharmaceutical Sciences, Wenzhou Medical University Wenzhou Zhejiang China Institute of Environmental Health & Related Products Safety, Chinese Center for Disease Control Prevention, Beijing, China. cdcchenxi@hotmail.com Department of Molecular & Cellular Biology, Baylor College of Medicine, Houston, TX Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.; Yunnan Branch, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Jing Hong, China. School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin 150000, China Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, MOE Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology , Wuhan, China Department of Pharmacy, Xiangya Hospital, Central South University, Hunan, China; Institute for Rational and Safe Medication Practices, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Hunan, China School of Environment, Beijing Normal University/State Key Laboratory of Water Environment Simulation, Beijing, 100875, China Department of Orthopedic Surgery, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China Virginia Polytechnic Institute and State University, Arlington Orthopaedic Institute, Department of Orthopaedics, The First Affiliated Hospital of Soochow University, 708 Renmin Rd, Suzhou, Jiangsu 215007, China Key Laboratory of Environmentally Friendly Chemistry and Applications of Ministry of Education, College of Chemistry, Xiangtan University, Xiangtan 411105, P. R. China School of Medicine, Tsinghua University, Beijing, China. Beijing Key Laboratory of Drug Target Identification and Drug Screening,Institute of Materia Medica, CAMS and PUMC,Beijing 100050,China. School of Chemical Engineering and Technology, Hebei University of Technology, Guangrong Dao No.8, Hongqiao District, Tianjin 300130, China School of Pharmacy, Lanzhou University, Lanzhou 730000, P. R. China Department of Pediatrics The First Affiliated Hospital of Nanjing Medical University Nanjing China State Key Laboratory of Explosion Science and Technology, Beijing Institute of Technology, No. 5, Zhongguancun South Street, Haidian District, Beijing 100081, China Centre for Micro-Photonics, Faculty of Engineering and Industrial Sciences, Swinburne University of Technology, P.O. Box 218, Hawthorn, 3122 Victoria, Australia School of Dentistry University of North Carolina at Chapel Hill Chapel Hill North Carolina Department of General Practice School of Nursing, Nanjing University of Chinese Medicine, Nanjing, China Department of Neurology, Huashan Hospital, Fudan University, Shanghai, China The MOE Key Laboratory of Biosystems Homeostasis and Protection and Zhejiang Provincial Key Laboratory for Cancer Molecular Cell Biology, Life Sciences Institute, Zhejiang University, Hangzhou, China. Department of Pharmacy Hebei University of Science and Technology Shijiazhuang People's Republic of China Department of Orthopedic Surgery, The First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, People’s Republic of China Department of Chemistry, ‡Department of Physics, and §Institute for Complex Adaptive Matter, University of California, 1 Shields Avenue, Davis, California 95616, United States Department of Medical Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong, People's Republic of China College of Animal Science and Technology, Northeast Agricultural University, Harbin, People’s Republic of China Physical and Life Sciences Directorate Lawrence Livermore National Laboratory Livermore CA 94550 USA; School of Natural Sciences University of California Merced Merced CA 95343 USA Department of Spine Surgery, Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing, China. Department of Civil Engineering and Engineering Mechanics, Columbia University, New York, NY 10027-6699; Department of Chemistry, Case Western Reserve University, Cleveland, Ohio 44106, United States Department of Otolaryngology Head and Neck Surgery, Navy General Hospital, Beijing, 100048, China. Reproductive Medical Center Renmin Hospital of Wuhan University Wuhan China Department of Chemistry, Brown University, Providence, Rhode Island 02912, United States Center for Vital Longevity, School of Behavioral and Brain Sciences University of Texas at Dallas Texas USA Centre for Artificial‐Intelligence Nanophotonics, School of Optical‐Electrical and Computer Engineering University of Shanghai for Science and Technology Shanghai China Beijing Key Laboratory of Membrane Science and Technology and Department of Environmental Science and Engineering, Beijing University of Chemical Technology, Beijing 100029, China Department of Chemistry University of California Davis CA 95616 USA Department of Urology, Tongji Hospital, School of Medicine, Tongji University , Shanghai , 200065 , China Department of Obstetrics and Gynaecology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, China (mainland) College of Life Science Nanjing Agricultural University Nanjing 210095 China Key Laboratory of Dai and Southern Medicine of Xishuangbanna Dai Autonomous Prefecture, Yunnan Branch, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Jinghong 666100, P.R. China Department of Biochemistry and Molecular Medicine, The George Washington University, Washington, DC; and Department of Endocrinology and Metabolism, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China Department of General Surgery Ruijin Hospital Shanghai Jiaotong University School of Medicine Shanghai China Department of Ophthalmology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China Department of Orthopaedic Surgery, West China Hospital Sichuan University Chengdu Sichuan China University of Science and Technology of China (USTC), Hefei 230026, China Department of Stem Cell Biology and Regenerative Medicine, Eli and Edythe Broad-CIRM Center for Regenerative Medicine and Stem Cell Research, Keck School of Medicine of the University of Southern California, Los Angeles, United States Helen Wills Neuroscience Institute University of California Berkeley Berkeley California USA Department of Ophthalmology, the First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China. Key Laboratory of Composite and Functional Materials School of Materials Science and Engineering Tianjin University Tianjin 300350 China College of Chemistry Chemical Engineering and Materials Science Soochow University Suzhou 215123 China Keenan Research Centre for Biomedical Science of St. Michael’s Hospital, Unity Health Toronto, Toronto, ON, Canada;; Department of Laboratory Medicine and; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada;; The Toronto Platelet Immunobiology Group, Toronto, ON, Canada; and State Key Laboratory of Quality Research in Chinese Medicine Macau University of Science and Technology Macau China VIP center, Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang, P. R. China National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100050, China Department of Medical Oncology, Tumor Hospital Affiliated to Nantong University & Nantong Tumor Hospital, Nantong 226000, China Department of Ears, Nose and Throat, The Third People's Hospital of Shenzhen, Shenzhen, Guangdong 518115, P.R. China Hunan Provincial Center for Disease Control and Prevention. Jiangxi Key Laboratory of Organic Chemistry, Jiangxi Science and Technology Normal University, Nanchang 330013, China State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, No.7 Jinsui Road, Tianhe District, Guangzhou City, China Shenzhen Key Laboratory of Micro/Nano Biosensing Shenzhen Institute of Advanced Technology Chinese Academy of Sciences Shenzhen 518055 P. R. China School of Stomatology Weifang Medical University Weifang China Department of Mechanical and Energy Engineering, Indiana University−Purdue University Indianapolis, Indianapolis, Indiana 46202, United States; Mechanical Engineering, Purdue University, 610 Purdue Mall, West Lafayette, Indiana 47907, United States Department of Chemistry, Texas A&M University, 580 Ross St, College Station, TX 77843, USA Laboratory of Biomedical Microsystems and Nano Devices, Bionic Sensing and Intelligence Center, Institute of Biomedical and Health Engineering, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, 518055 Shenzhen, China Laboratory of Immunology, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health, Bethesda, MD 20892, USA. Center for Reproductive Sciences and Department of Obstetrics and Gynecology, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, New York, NY 10032, USA.; Departments of Pathology and Surgery, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, New York, NY 10032, USA.; Department of Biochemistry, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA.; Department of Immunology, Harbin Medical University, Harbin 150086, China.; Department of Neurology, New York University, New York, NY 10003, USA. ORIC Pharmaceuticals, 240 E. Grand Avenue, Floor 2, South San Francisco, California 94080, United States Institute of Biomaterials and Biomedical Engineering, University of Toronto, 164 College Street, Toronto, Ontario M5S 3G9, Canada Department of Cell and Developmental Biology Perelman School of Medicine at the University of Pennsylvania Philadelphia Pennsylvania State Key Laboratory of Low Dimensional Quantum Physics, Department of Physics, Tsinghua University 1 , Beijing 100084, China School of Basic Medicine, Qingdao University, Qingdao 266000, China Shanghai Key Laboratory of Regulatory Biology Institute of Biomedical Sciences and School of Life Sciences East China Normal University Shanghai China College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China 1Radiation Oncology Research Laboratory and Marlene and Stewart Greenebaum Cancer Center, College of Plant Protection, China Agricultural University, Beijing 100193, China Institute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, PR China;; State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau, PR China; School of Life Sciences, University of Science and Technology of China, Hefei 230027, China (L.Y., X.C., Z.W., C.X.) Department of Gynecology The First Affiliated Hospital of China Shenyang China College of Chemistry and Material Science; South Central University for Nationalities; Wuhan 430074; People's Republic of China State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China; Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou 510060, China Drug Discovery Research Center, Mitchell Cancer Institute, University of South Alabama, Mobile, Alabama, USA SCIEX Analytical Instrument Trading Co., Shanghai, 200335, P. R. China Key Laboratory of Optoelectronic Materials Chemistry and Physics, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou 350002, P. R. China; University of Chinese Academy of Sciences, Beijing 100049, P.R. China College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, China State Key Laboratory of Applied Organic Chemistry, School of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, P. R. China Department of Health Assessment Intervention, Guangzhou Cadre Health Management Center, Guangzhou, China Department of Chemistry and Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials; Fudan University; Shanghai 200433; P. R. China Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom Affiliated Hospital of Medical School Ningbo University, Ningbo, China State Key Laboratory of Low-Dimensional Quantum Physics, Department of Physics, Tsinghua University, Beijing 100084, China; Collaborative Innovation Center of Quantum Matter, Beijing 100084, China Department of NeurologyCollege of Physicians & Surgeons of Columbia University 630 West 168th Street New York NY 10032 Center for Vital Longevity, School of Behavioral and Brain Sciences, University of Texas at Dallas, Dallas, TX, USA Department of Chemistry; University of Missouri; Columbia; USA Department of Earth and Environmental Engineering, Columbia University, 500 W 120th Street, New York, NY 10027, USA and International Center for Applied Mechanics, SV Lab, School of Aerospace, Xi'an Jiaotong University, Xi'an 710049, China Department of Dermatology Jinshi Clinic Shanghai People's Republic of China Department of Gastrointestinal Surgery, Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, P.R. China School of Nursing, The Hong Kong Polytechnic University, Hong Kong SAR, China Neuroimaging Research Branch National Institute on Drug Abuse National Institutes of Health Baltimore Maryland USA Department of Oncology, The 900th Hospital of the People’s Liberation Army Joint Service Support Force, Fuzong Clinical Medical College of Fujian Medical University, Fuzhou, Fujian, China Cereals and Oils Quality and Safety Research Institution; Academy of National Food and Strategic Reserves Administration (Former Name: Academy of State Administration of Grain); Beijing 102600; China Information Center, Capital University of Economics and Business, Beijing 10070, China Department of Ophthalmology The First Affiliated Hospital of Nanjing Medical University Nanjing Jiangsu P. R. China Departments of Physics and Chemistry, Nanoscience Center, University of Jyväskylä, FI-40014 Jyväskylä, Finland Department of Orthopedic Surgery, Peking Union Medical College Hospital Peking Union Medical College and Chinese Academy of Medical Sciences China Department of Orthopaedics, The First Affiliated Hospital of Soochow University, No. 188 Shizi Street, Suzhou 215153, Jiangsu, China; Orthopaedic Institute, Medical College, Soochow University, No. 708 Renmin Road, Suzhou 215007, China; School of Biology and Basic Medical Sciences, Medical College, Soochow University, No. 199 Renai Road, Suzhou 215123, China Ministry of Agriculture Key Lab of Molecular Biology of Crop Pathogens and Insect Pests Institute of Insect Sciences College of Agriculture and Biotechnology Zhejiang University Hangzhou China Department of Chemical and Biomolecular Engineering National University of Singapore 4 Engineering Drive 4 117585 Singapore Singapore Department of Pharmacy The First Hospital of China Medical University Shenyang China Department of Physics, Shanghai Key Laboratory of Materials Protection and Advanced Materials in Electric Power, Shanghai University of Electric Power, Shanghai 200090, China National Engineering Laboratory for Industrial Enzymes and Tianjin Engineering Research Center of Biocatalytic Technology, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, 32 West seventh Avenue, Tianjin Airport Economic Area, Tianjin 300308, China Department of Epidemiology, Faculty of Navy Medicine, Second Military Medical University, 8 Panshan Rd, Yangpu District, Shanghai 200433, China Department of ChemistryUniversity of California at DavisDavisCaliforniaUSA Department of Chemistry and Key Laboratory of Analytical Sciences of Xiamen University, College of Chemistry and Chemical Engineering, and State Key Laboratory of Marine Environmental Science, Xiamen University, Xiamen 361005, China The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu 610054, China Department of Colorectal Surgery, The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, P. R. China; Guangdong Institute of Gastroenterology, Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, P. R. China Department of Chemistry Nanoscience Center University of Jyväskylä Jyväskylä FI‐40014 Finland Department of Pharmacy, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, P.R. China Western Research Center for Energy and Eco-Environmental Policy, State Key Laboratory of Desert and Oasis Ecology, Xinjiang Institute of Ecology and Geography, Chinese Academy of Sciences, Urumqi 830011, China. West China School of Pharmacy, Sichuan University; Department of Clinical Pharmacy and Pharmacy Administration; Chengdu Sichuan China 610041 Department of Pharmacology, Peking University, School of Basic Medical Science , Beijing , China Neurology Department and Nursing Department, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen 518107, China Department of Chemistry Key Lab of Organic Optoelectronics & Molecular Engineering Tsinghua University Beijing 100084 P. R. China International Research Centre for Environmental Membrane Biology Foshan University Foshan 528000 China; School of Biological Sciences University of Western Australia Crawley Western Australia 6009 Australia Division of Diabetes, Department of Medicine, University of Texas Health Science Center, San Antonio, TX Shanghai Mental Health Center, Shanghai Jiao Tong University, School of Medicine, Shanghai, China; Shanghai Key Laboratory of Psychotic Disorders, Shanghai, China State Key Laboratory of Hybrid Rice, College of Life Sciences Wuhan University Wuhan China Nanjing Drum Tower Hospital Center of Molecular Diagnostic and Therapy, Chinese Academy of Medical Sciences Research Unit of Extracellular RNA, State Key Laboratory of Pharmaceutical Biotechnology, Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, NJU Advanced Institute of Life Sciences (NAILS), Institute of Artificial Intelligence Biomedicine, School of Life Sciences, Nanjing University, Jiangsu, China (Z.W., Y.T., J.X., H.W., Y.S., L.C., Jing Li, Y.Z., X.C., D.W., C.-Y.Z.... Department of Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College (CAMS & PUMC), Beijing 100730, China State Key Laboratory of Desert and Oasis Ecology Xinjiang Institute of Ecology and Geography Chinese Academy of Sciences Urumqi Xinjiang China; CAS Research Center for Ecology and Environment of Central Asia Urumqi Xinjiang China Department of Materials Imperial College London London SW7 2AZ UK; Department of Computer Science University of Southern California Los Angeles CA USA Department of Medical Oncology, Sun Yat-sen University Cancer Center, Guangzhou 510060, PR China; State Key Laboratory of Oncology in South China, Guangzhou 510060, PR China; Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, PR China Department of Computer Science, Zhejiang University, Hangzhou 310027, China 1Department of Pathology and Key Laboratory for Xinjiang Endemic and Ethnic Diseases, The First Affiliated Hospital, Shihezi University School of Medicine, Shihezi, China. Department of Plastic and Reconstructive Surgery, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, P.R. China Texas A&M University, Department of Biomedical Engineering, College Station, Texas Polymers and Biomaterials Field; Research Center for Functional Materials; National Institute for Materials Science; Tsukuba; Japan Department of Dermatology Rizhao Hospital of traditional Chinese Medicine Shandong University of traditional Chinese Medicine Rizhao China State Key Lab of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun 130012, China State Key Laboratory of Ophthalmology, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Zhongshan Ophthalmic Center Sun Yat‐sen University Guangzhou China The Academy of National Food and Strategic Reserves Administration (Former Name: Academy of State Administration of Grain, ab. ASAG); Beijing 100037; China State Key Lab of Supramolecular Structure and Materials; College of Chemistry; Jilin University; Changchun 130012; China Department of Neuroscience City University of Hong Kong Kowloon Hong Kong China Key Laboratory of Marine Biogenetic Resources, Third Institute of Oceanography State, Ministry of Natural Resources, Da-Xue Road, Xiamen 361005, People’s Republic of China National Engineering Laboratory for Industrial Enzymes and Tianjin Engineering Center for Biocatalytic Technology Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences Tianjin 300308 P. R. China State Key Laboratory of Medicinal Chemical Biology and College of Pharmacy, Nankai University, Tianjin 300071, China, Center for Diagnostics & Therapeutics and Department of Chemistry, Georgia State University, Atlanta, Georgia 30303, United States, and Department of Chemistry, University of California, Davis, One Shields Avenue, Davis, California 95616, United States Shanghai Chemical Environmental Monitoring Station, Shanghai 200042, China. Department of Gynecology, The First Affiliated Hospital of China Medical University, Shenyang, China Department of Polymer Materials and Chemical Engineering, East China Jiaotong University, Nanchang 330013, PR China Department of Pediatrics, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China The MOE Key Laboratory of Biosystems Homeostasis & Protection and Zhejiang Provincial Key Laboratory for Cancer Molecular Cell Biology Life Sciences Institute Zhejiang University Hangzhou China College of Chemistry, Chemical Engineering and Materials Science Soochow University Suzhou 215123 China Department of Chemistry; University of California, Davis; Davis; USA 1 Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, Institute of Pharmacology and Toxicology, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China. State Key Laboratory of Pharmaceutical Biotechnology, NJU Advanced Institute for Life Sciences (NAILS), Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, School of Life Sciences, Nanjing University, Nanjing, Jiangsu 210046, China Department of Hematology, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, China Institute of Organic Chemistry, Jiangxi Science &Technology Normal University, Key Laboratory of Organic Chemistry, Jiangxi Province, Nanchang 330013, China Department of Public Health, Zhejiang University , Hangzhou, China Department of Chemistry, The Chinese University of Hong Kong, Hong Kong, China Department of Chemical & Environmental Engineering and Materials Science & Engineering Program, University of California-Riverside, Riverside, California 92521, United States Department of Electrical Engineering, The Pennsylvania State University, University Park, Pennsylvania 16802, United States 1Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, New York. Department of Hematology, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang�150036, P.R. China School of Chinese Materia Medica, Tianjin University Traditional Chinese Medicine, Tianjin 300193, P.R. China Department of Neurosurgery The First Affiliated Hospital of Xiamen University Xiamen China Department of Plastic and Reconstructive Surgery, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China. Contribution from the Department of Structural Engineering, University of California at San Diego, La Jolla, California 92093-0085, and Department of Civil Engineering and Engineering Mechanics, Columbia University, New York, New York 10027-6699 Department of Pharmacology, Beijing Key Laboratory of Drug Resistance Tuberculosis Research, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing, People’s Republic of China State Key Laboratory of Marine Environmental Science; Xiamen University; Xiamen, China Key Laboratory of Environment and Health (HUST), Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China State Key Laboratory of Physical Chemistry of Solid Surfaces; College of Chemistry and Chemical Engineering; Xiamen University; Xiamen; People's Republic of China State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Taipa, Macau SAR, China Guangdong Province Engineering Research Center for Antibody Drug and Immunoassay Department of Biology Jinan University Guangzhou P. R. China Department of Chemistry and the Section of Molecular and Cellular Biology, University of California, One Shields Avenue, Davis, California 95616 College of Plant Protection, China Agricultural University, Beijing, 100193, China Laboratory for Multifunctional Materials, Department of Materials, ETH Zurich, Vladimir-Prelog-Weg 5, 8093 Zurich, Switzerland Department of Economics, Yale University, New Haven, CT 06520; and; Department of Sociology, Quinnipiac University, Hamden, CT 06518 Department of Pharmaceutics, Key Lab of State Natural Medicine, China Pharmaceutical University, Nanjing 210009, China Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics, School of Pharmaceutical Sciences, Tianjin Medical University, Tianjin 300070, China College of Chemistry and Chemical Engineering Xiamen University Xiamen 361005 China Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina Department of Orthopedic Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania Shanghai Key Laboratory of Atmospheric Particle Pollution and Prevention (LAP3), Department of Environmental Science and Engineering, Fudan University, 220 Handan Road, Shanghai 200433, P. R. China Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA 1 Department of Cardiology, 2 Department of Laboratory Medicine, Wuxi Second People's Hospital of Nanjing Medical University, Wuxi 214002, China. State Key Laboratory of Pharmaceutical Biotechnology, Department of Gastroenterology, Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, Jiangsu 210093, China Laboratory for Multifunctional Materials, Department of Materials, ETH Zurich, Vladimir-Prelog-Weg 5, 8093, Zurich, Switzerland Tianjin Key Laboratory of Composite and Functional Materials School of Materials Science and Engineering Tianjin University Tianjin 300350 China State Key Laboratory for Low-Dimensional Quantum Physics, Department of Physics, Tsinghua University, Beijing 100084, the People’s Republic of China. 2Division of Biostatistics and Bioinformatics, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, Florida. Sports Medicine Center, West China Hospital, Sichuan University, Chengdu, China; Department of Orthopedics and Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu, China Technical Center of Dalian Customs, Dalian 116000, China Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, Hunan, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China Institute of Medicine and Materials Applied Technologies; College of Chemistry and Chemical Engineering; Qufu Normal University; Qufu; P. R. China Peking University People's Hospital Beijing China Division of Biostatistics Department of Public Health Sciences University of Miami Miller School of Medicine Miami FL 33136 USA; Sylvester Comprehensive Cancer Center University of Miami Miller School of Medicine Miami FL 33136 USA School of Stomatology Weifang Medical University Weifang Shandong China Reproductive Medical Center, Peking University People's Hospital, Beijing 100044, China. Center for Surgery and Public Health, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts Department of Clinical Laboratory Center, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences Peking Union Medical College Beijing China 1Department of Epidemiology, Second Military Medical University, Shanghai, China. National Engineering Laboratory for Industrial Enzymes, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, China. 1The State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, China. Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy Xuzhou Medical University Xuzhou Jiangsu China Sauvage Laboratory for Smart Materials, School of Materials Science and Engineering, Harbin Institute of Technology (Shenzhen), Shenzhen 518055, China Department of Hematology, the Second Affiliated Hospital of Harbin Medical University, Harbin, People’s Republic of China Department of Neurology Yongchuan Hospital of Chongqing Medical University Chongqing China; Institute of Neuroscience and Collaborative Innovation Center for Brain Science Chongqing Medical University Chongqing China; Chongqing Key Laboratory of Neurobiology Chongqing China Columbia Nanomechanics Research Center; Department of Earth and Environmental Engineering; Columbia University; New York; USA College of Pharmaceutical Engineering of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine , Tianjin, 301617 , P. R. China Department of Chemical Engineering Department of General Surgery, The First Affiliated Hospital of Soochow University, Soochow; Department of General Surgery, Affiliated Hospital of Nantong University, Nantong Department of Statistics, Department of Biomedical Data Science, Bio-X Program, Stanford University, Stanford, CA 94305; Clinical Anatomy & Reproductive Medicine Application Institute, Hengyang Medical School University of South China Hengyang Hunan China Department of Chemistry, University of California-Davis, Davis, CA. Third Level Research Laboratory of State Administration of Traditional Chinese Medicine, Guangdong Provincial Key Laboratory of Chinese Medicine Pharmaceutics, School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China; Guangdong Provincial Key Laboratory of Chinese Medicine Pharmaceutics, School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China Department of Geriatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Wuhan 430030, China Department of Mechanical Engineering, Stevens Institute of Technology, Castle Point on Hudson, Hoboken, New Jersey 07030 Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138 Division of Solid-State Electronics, Department of Engineering Sciences, The Ångström Laboratory, Uppsala University, P.O. Box 534, SE-751 21 Uppsala, Sweden Faculty of Nursing, Burapha University, Chon Buri, Thailand; Yancheng NO.1 People's Hospital in Jiangsu, Jiangsu, China The State Key Laboratory of Agricultural Microbiology, Wuhan, Hubei 430070, China; College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, Hubei 430070, China Department of Chemistry, One Shields Avenue, University of California, Davis, California 95616 Department of Pathology, West China Hospital, Sichuan University, Chengdu, Sichuan, China CAS Center for Excellence in Regional Atmospheric Environment, and Key Laboratory of Urban Pollutant Conversion, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen 361021, P. R. China; University of Chinese Academy of Sciences, Beijing 100049, P. R. China Department of Plant Pathology, The Pennsylvania State University, University Park, Pennsylvania 16802 Guangxi Key Laboratory of Agro-Environment and Agric-Products Safety, College of Agriculture, Guangxi University , Nanning 530004 , P. R. China; Hunan Linji Ecological Technology Co. LtD. , Hunan Province, Changsha 410000 , P. R. China Department of Dermatology, Peking University People's Hospital, Beijing 100044, China Laboratory of Immunology, Research Centre for Medical Science and Department of Biology, Tsinghua University, and Protein Science Laboratory of MOE, Beijing 100084, Peoples Republic of China. National Key Laboratory of Science and Technology on Advanced Composites in Special Environments; Harbin Institute of Technology; Harbin 150001; P. R. China State Key Laboratory of Turbulence and Complex Systems and Department of Mechanics and Engineering Science, College of Engineering, Peking University, Beijing 100871, People's Republic of China Institute of Physics, Chinese Academy of Sciences, Beijing 100190, China, and Department of Physics, Tsinghua University, Beijing 100084, China Center for Clinical Molecular Medicine, Children’s Hospital of Chongqing Medical University, Chongqing, China;; Ministry of Education Key Laboratory of Child Development and Disorders, Children’s Hospital of Chongqing Medical University, Chongqing, China;; Chongqing Key Laboratory of Pediatrics, Children’s Hospital of Chongqing Medical University, Chongqing, China; Department of Materials Science and Engineering, North Carolina State University, Raleigh, North Carolina 27601, United States Guizhou Institute of Prataculture, Guizhou Academy of Agricultural Sciences, Guiyang 550006, Guizhou, China. National-Local Joint Engineering Research Center of Karst Region Plant Resources Utilization & Breeding of Guizhou Province, Guizhou University, Guiyang 550025, Guizhou, China. Key Laboratory of Plant Resources Conservation and Germplasm Innovation in Mountainous Region, Ministry of Education, Guiyang 550025, Guizhou, China. Hunan Institute of Agricultural Biotechnology, Changsha 410000, PR China Department of Mechanical Engineering, Indiana University-Purdue University Indianapolis (IUPUI), 723 West Michigan Street, Indianapolis, Indiana 46202, United States; Purdue University, West Lafayette, Indiana 47907, United States Department of Infectious Diseases, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China School of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin, China Ministry of Education Key Laboratory of Molecular and Cellular Biology Hebei Anti‐tumor Molecular Target Technology Innovation Center College of Life Science Hebei Normal University Shijiazhuang 050024 China State Key Laboratory of Fine Chemicals; School of Chemical Engineering; Dalian University of Technology; Dalian; P. R. China State Key Laboratory of Vegetation and Environmental Change, Institute of Botany, Chinese Academy of Sciences, Beijing, People's Republic of China; Centrum für Biotechnologie, Universität Bielefeld, Bielefeld, Germany; State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing, People's Republic of China; Graduate University of Chinese Academy of Sciences, Beijing, People's Republic of China From the Departments of Neurology (X.C., L.M.D., T.K.) and Medicine (G.K.S., R.D.C.), Memorial Sloan-Kettering Cancer Center, New York, NY. Department of Earth and Environmental Engineering, Columbia University 1 , New York, New York 10027, USA Pearl River Estuary Chinese White Dolphin National Nature Reserve, Zhuhai, Guangdong, P.R. China Department of Industrial Engineering, University of Washington, Seattle, Washington 98195, Department of Chemistry, University of Montreal, Montreal, QC H3C 3J7, Canada, and Palo Alto Research Center, 3333 Coyote Hill Road, Palo Alto, California 94304 Department of Orthopedics, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, PR China Department of Cardiology, The First Affiliated Hospital, Cardiovascular Institute, Harbin Medical University, 23 Youzheng Street, Harbin, PR China Department of Molecular and Cellular Biochemistry, ‡Department of Surgery, and §Markey Cancer Center, University of Kentucky, Lexington, Kentucky 40506-0509, United States School of Materials Science and Engineering, North China University of Water Resources and Electric Power, Zhengzhou, 450045, China Key Laboratory of Industrial Ecology and Environmental Engineering (Ministry of Education), Dalian Key Laboratory on Chemicals Risk Control and Pollution Prevention Technology, School of Environmental Science and Technology, Dalian University of Technology, Dalian 116024, China Biologics Development Sciences, Janssen Biotherapeutics, Janssen Research & Development, LLC, Spring House, PA, USA College of Safety Science and Engineering, Taiyuan University of Technology, Taiyuan 030024, China State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China; Hubei International Scientific and Technological Cooperation Base of Veterinary Epidemiology, The Cooperative Innovation Center for Sustainable Pig Production, Wuhan 430070, China Department of Pharmaceutics, Key Lab of State Natural Medicine, China Pharmaceutical University, Nanjing 210009, P. R. China College of Bioinformatics Science and Technology; the Fourth Affiliated Hospital; Harbin Medical University; Harbin, China State Key Laboratory of Advanced Welding and Joining, Harbin Institute of Technology, Harbin 150001, China Department of Urology No. 971 Hospital of the People's Liberation Army Navy Qingdao China; Department of Urology, Shanghai Changhai Hospital Second Military Medical University Shanghai China Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences, Wuhan 430071, China Department of Gynecologic Oncology, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, Zhejiang 310022, China School of Electronic and Information Engineering, Beihang University, Beijing 100191, China; Research Institute for Frontier Science, Beihang University, Beijing 100191, China Department of Pathogen Biology and Immunology, Kunming Medical University, Kunming, China; Department of Pharmacy, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China Department of Statistics, Stanford University, Stanford, CA State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan 430070, China; Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China Center for Clinical Molecular Medicine, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatrics Chongqing International Science and Technology Cooperation Center for Child Development and Disorders, Children's Hospital of Chongqing Medical University Chongqing China International Initiative on Spatial Lifecourse Epidemiology (ISLE); Department of Health Policy and Management, Yale School of Public Health, New Haven, Connecticut, USA; Yale Climate Change and Health Initiative, New Haven, Connecticut, USA Department of Immunology School of Basic Medical Sciences Southern Medical University Guangzhou China Department of General Surgery, The Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, P.R. China Department of Mechanical Engineering, Purdue University, 585 Purdue Mall, West Lafayette, Indiana 47907, United States; Department of Mechanical and Energy Engineering, IUPUI, 723 W. Michigan Street, Indianapolis, Indiana 46202, United States ARC Centre of Excellence in Convergent Bio-Nano; Science and Technologyand Department of Chemical and Biomolecular Engineering; The University of Melbourne; Parkville Victoria 3010 Australia The Second Affiliated Hospital of Harbin Medical University,Department of Mammary Surgery,Harbin,China Institute of Human Virology, Key Laboratory of Tropical Disease Control of Ministry of Education, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China Department of Hepatobiliary and Pancreatic Surgery, Zhongnan Hospital of Wuhan University, Donghu Road 169# Wuhan 430071, China Albany Molecular Research Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, United Kingdom; Department of Epidemiology and Health Statistics, School of Public Health Fudan University Shanghai China Laboratory for Earth Surface Processes, College of Urban and Environmental Sciences, Peking University, Beijing 100871, People’s Republic of China Institute of Combined Injury State Key Laboratory of Trauma Burns and Combined Injury Chongqing Engineering Research Center for Nanomedicine Chongqing Engineering Research Center for Biomaterials and Regenerative Medicine College of Preventive Medicine Army Medical University (Third Military Medical University) 30th Gaotanyan street Chongqing 400038 China School of Electrical and Electronic Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore Center for Vital Longevity, School of Behavioral and Brain Sciences, University of Texas at Dallas, Dallas Department of Respiratory Medicine, Xinhua Hospital Affiliated with Shanghai Jiao Tong University School of Medicine, Shanghai, China; and Department of Radiation Oncology, Key Laboratory of Cancer Prevention and Therapy, National Clinical Research Centre of Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China Department of Epidemiology Second Military Medical University Shanghai China State Key Laboratory of Marine Environmental Science, Xiamen University, Xiamen, China McLean Hospital, Harvard Medical School, Belmont, MA, USA Institute of Chemistry Chinese Academy of Sciences Beijing 100190 P. R. China Ministry of Education Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau Department of Applied Physics; Xi'an Jiaotong University; Xi'an 710049; China Beijing Key Laboratory of Drug Resistance Tuberculosis Research, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing, China National Engineering Laboratory for Industrial Enzymes and Tianjin Engineering Center for Biocatalytic Technology, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China Department of Chemistry; University of California; Davis, USA Materials Science and Engineering Program, The University of Texas at Austin, Austin, TX 78712;; Texas Materials Institute, The University of Texas at Austin, Austin, TX 78712; Huazhong University of Science and Technology 1 School of Automation, , Wuhan 430074, China; Non-Traditional Security Center of Huazhong University of Science and Technology 2 , Wuhan 430074, China; Image Processing and Intelligent Control Key Laboratory of Education Ministry of China 3 , Wuhan 430074, China Department of Chemistry, Key Laboratory of Green Chemistry and Technology (Ministry of Education), Sichuan University, Chengdu, Sichuan 610064, China, State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan 610041, China, and Department of Chemistry, University of Virginia, Charlottesville, Virginia 22904-4319 Materials Science and Engineering Program and Texas Materials Institute, The University of Texas at Austin, Austin, Texas 78712, United States School of Chemistry; MOE Key Laboratory for Nonequilibrium Synthesis and Modulation of Condensed Matter; State Key Laboratory for Mechanical Behavior of Materials; Xi'an Jiaotong University; Xi'an 710049 Authors' Affiliations: 1Vanderbilt-Ingram Cancer Center, the Department of Medicine/Division of Hematology-Oncology, 2Department of Biostatistics/Division of Cancer Biostatistics, 3Center for Quantitative Science, Vanderbilt University School of Medicine; 4Departments of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee; 5Department of Pathology, 6Massachusetts General Hospital Cancer Center; 7Harvard Medical School, Boston, Massachusetts; 8Department of Pathology, 9Thoracic Oncology Service, Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York; 10Johns Hopkins University, Baltimore, Maryland; 11Catalan Institute of Oncology, Universitat Autonoma de Barcelona and Hospital Universitari Germans Trias i Pujol, Barcelona, Spain; 12University of Colorado Cancer Center, Aurora, Colorado; 13Department of Surgery II, Nagoya City University Medical School, Nagoya, Japan; 14Translational Oncology Research L Department of Chemistry and Biochemistry, Florida International University, Miami, Florida 33199 State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China; University of Chinese Academy of Sciences, Beijing, China Department of Ophthalmology, Duke University School of Medicine, Durham, North Carolina McLean Hospital, Belmont, MA; Harvard Medical School, Boston, MA Center for Joint Quantum Studies and Department of Physics School of Science Tianjin University Tianjin 300350 P. R. China Department of Hematology, The Second Affiliated Hospital of Harbin Medical University, Harbin, People’s Republic of China State Key Laboratory of Applied Organic Chemistry, School of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, P.R. China The State Key Laboratory of Agricultural Microbiology 430070 Wuhan China; College of Veterinary MedicineHuazhong Agricultural University 430070 Wuhan China Department of Respiratory Medicine, Xiangya Hospital of Central South University, Changsha, Hunan 410008, China Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, P.R. China. The Hong Kong Polytechnic University Shenzhen Research Institute, Shenzhen, 518057, China.; Research Institute of Smart Ageing, The Hong Kong Polytechnic University, Hong Kong, China.; Department of Biomedical Engineering, The Hong Kong Polytechnic University, Hong Kong, China. Department of Neurobiology, School of Basic Medical Sciences, Neuroscience Research Institute, Beijing, Peoples Republic of China School of Engineering and Applied Sciences, Columbia University, New York, New York 10027; Department of Earth and Environmental Engineering, Columbia University, New York, New York 10027 Department of Hepatobiliary Surgery of the Affiliated Taizhou People's Hospital of Nanjing Medical University Taizhou Jiangsu Province China College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China Life Sciences Institute, The Second Affiliated Hospital and School of Medicine, The MOE Key Laboratory of Biosystems Homeostasis and Protection and Zhejiang Provincial Key Laboratory for Cancer Molecular Cell Biology, Zhejiang University, Hangzhou, Zhejiang 310058, China. Department of Endocrinology Department of Central Laboratory, The Children’s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, Zhejiang, China Department of Anesthesiology, China-Japan Union Hospital of Jilin University, Changchun 130033, China National Engineering Research Center of Light Alloy Net Forming; State Key Laboratory of Metal Matrix Composites; Shanghai Jiao Tong University; Shanghai; P. R. China Department of Civil Engineering and Engineering Mechanics, Columbia University, New York, New York 10027-6699, and Department of Structural Engineering, and Program of Materials Science and Engineering, University of California−San Diego, La Jolla, California 92093-0085 Sauvage Laboratory for Smart Materials, School of Materials Science and Engineering, Harbin Institute of Technology (Shenzhen), Shenzhen 518055, China; Institute of Biomedical Engineering, University of Toronto, Toronto M5S 3E1, Canada; Department of Chemistry, University of Toronto, Toronto M5S 3H6, Canada; Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto M5S 3E1, Canada College of Biomedical Engineering & Instrument Science Zhejiang University Hangzhou China Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33136, USA.; Department of Public Health Sciences, University of Miami Miller School of Medicine, Miami, FL 33136, USA. Université Paris Cité, CNRS, Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologiques Paris France Center for Surgery and Public Health, Brigham and Women’s Hospital, Harvard Medical School , Boston, MA, USA Orthopedic Surgery, Peking Union Medical College, Chinese Academy of Medical Sciences, Peking Union Medical College Hospital Department of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of NPC Diagnosis and Therapy, Guangzhou, China GEIRI North America, San Jose, CA, USA Nokia Bell Labs *State Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Nankai University, Tianjin 300071, China; Department of Chemistry; University of California; Davis; USA Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, P.R. China Department of Gastroenterology, West China Hospital, Sichuan University, Chengdu 610041, China. From the Department of Obstetrics & Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (J.X., Y.F., W.L., L.F., J.L., X. Zeng, K.C., X.C., S.C.); Department of Urology, Zhengzhou First People’s Hospital, Henan, China (X.L.); Department of Obstetrics & Gynecology, The Second Affiliated Hospital of Zhengzhou University, Henan, China (X. Zhou); and Division of Laboratory Medicine, Department of Pathology, The University of... Department of Hematology, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, 150001, PR China Breast Surgery Department, The Second Affiliated Hospital of Harbin Medical University, Harbin, China Institute of Environmental Engineering (IfU), ETH Zürich, ZürichCH-8093, Switzerland Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, Hunan, China; Institute for Rational and Safe Medication Practices, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China Department of immunology School of Basic Medical Sciences Fudan University Shanghai 200032 China State Key Laboratory of Polymer Physics and Chemistry, Institute of Chemistry, Chinese Academy of Sciences, Beiing 100190, China; University of Chinese Academy of Sciences, Beijing 100049, China Department of Orthopaedics Peking Union Medical College Hospital, CAMS & PUMC Beijing China National Engineering Laboratory for Industrial Enzymes and Tianjin Engineering Center for Biocatalytic Technology, Tianjin Institute of Industrial Biotechnology Chinese Academy of Sciences Tianjin 300308 P.R. China ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, and ‡the Department of Chemical and Biomolecular Engineering, The University of Melbourne, Parkville, Victoria 3010, Australia Research Center for Ecology and Environment of Central Asia, Chinese Academy of Sciences , Urumqi , China; State Key Laboratory of Desert and Oasis Ecology, Xinjiang Institute of Ecology and Geography, Chinese Academy of Sciences , Urumqi , China Department of Orthopedics, Deyang People’s Hospital, Deyang, Sichuan, China Department of Radiation Oncology, Tianjin Medical University Cancer Institute & Hospital, Tianjin, People's Republic of China Department of General Surgery, The Second Affiliated Hospital of Medical School Xi'an Jiaotong University Xi'an Shaanxi 710004 People's Republic of China College of Science, Nanjing Agricultural University, Nanjing, People’s Republic of China 210095 Authors' Affiliations: Departments of 1Surgery, 2Cancer Biology, 3Pathology, and 4Biostatistics, Vanderbilt University School of Medicine, Nashville, Tennessee; 5Department of Pharmaceutical Sciences, University of Kentucky, Lexington, Kentucky; and 6Department of Medicine, Washington University School of Medicine, St. Louis, Missouri College of Veterinary Medicine, Yunnan Agricultural University, Kunming 650201, China; Center for Poultry Disease Control and Prevention, Yunnan Agricultural University, Kunming 650201, China Department of Internal Medicine 3 – Rheumatology and Immunology, Friedrich‐Alexander Universität Erlangen‐Nürnberg (FAU) and Universitätsklinikum Erlangen, and Deutsches Zentrum fuer Immuntherapie, Friedrich‐Alexander‐Universität Erlangen‐Nürnberg and Universitätsklinikum Erlangen Germany Minnesota Dental Research Center for Biomaterials and Biomechanics Department of Restorative Sciences School of Dentistry, University of Minnesota 55455 Minneapolis MN USA Department of Materials Science and Engineering, Drexel University, 3141 Chestnut Street, Philadelphia, Pennsylvania 19104, United States Department of Pediatrics, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China Department of Biology, Botanical Institute, Christian-Albrechts-University, 24118 Kiel, Germany; Department of Spine Surgery, Drum Tower Hospital, Clinical College of Nanjing Medical University, Nanjing, Jiangsu Province, China Chinese Academy of Sciences; University of Chinese Academy of Sciences Department of Physiology Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological Disorders and State Key Disciplines: Physiology School of Basic Medicine Qingdao University Qingdao China State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan 430070, China; College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China Endocrine Metabolic Disease Section Department of Cardiothoracic Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu 210002, P.R. China Division of Nephrology, Le Bonheur Children's Hospital, Memphis, Tennessee;; Center for Clinical and Translational Medicine, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio; Jarvis Lab, Tencent, Shenzhen, China Zigong Center for Disease Control and Prevention, Zigong, Sichuan, PR China College of Physics and Electronic Engineering Information; Wenzhou University; China Institute of Crop Science and Institute of Bioinformatics, Zhejiang University, Hangzhou 310058, China; Zhejiang University, Hangzhou 310058, China School of Chemical Engineering, Northwest University, Xi’an 710069, China Center for Advanced Optoelectronic Functional Materials Research, and Key Laboratory for UV-Emitting Materials and Technology of Ministry of Education, ‡School of Life Sciences, and §School of Geographic Sciences, Northeast Normal University, 5268 Renmin Street, Changchun 130024, China Department of Earth and Environmental Engineering Columbia University, 905E Mudd 500 West 120th Street New York NY 10027 USA State Key Laboratory of Fine Chemicals; School of Chemical Engineering; Dalian University of Technology; Dalian 116024; P. R. China Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu, Sichuan, China Department of Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, China Guangxi Key Laboratory of Fruits and Vegetables Storage-Processing Technology, Guangxi Academy of Agricultural Sciences, Nanning 530007, China; Guangxi South Subtropical Agricultural Science Research Institute, Guangxi Academy of Agricultural Sciences, Longzhou 532415, China Center for Composite Materials and Structure; Harbin Institute of Technology; Harbin 150001; P. R. China Authors' Affiliations: 1Institute for Virology, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, 2Department of Epidemiology and Biostatistics, Cancer Center, Nanjing Medical University, and 3Clinical Laboratory, Nanjing Second Hospital, Nanjing, China; and 4Department of Virology, University of California School of Public Health, Berkeley, California Department of Pathophysiology, Research Center of Molecular Medicine and Cancer, Chongqing Medical University, Chongqing 400016, China. Dr. Neher's Biophysics Laboratory for Innovative Drug Discovery State Key Laboratory of Quality Research in Chinese Medicine Macau University of Science and Technology Taipa Macau China Institute of Theoretical Chemistry; Jilin University; Changchun 130023 China Duke Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, USA Key Laboratory of Molecular Epigenetics of the Ministry of Education (MOE) Northeast Normal University Changchun P. R. China Peking-Yale Joint Center for Plant Molecular Genetics and Agro-Biotechnology, National Laboratory of Protein Engineering and Plant Genetic Engineering, College of Life Sciences, Peking University, Beijing 100871, China (L.-J.Q., J.C., M.L., N.P., H.O., D.L., J.W., G.Z., X.Z., X.C., H.G., Z.C.); China Agriculture University, Beijing 100094, China (Z.C.); Institute of Crop Breeding and Cultivation, Center for Stem Cell Biology and Regenerative Medicine, School of Medicine, Tsinghua University , Beijing 100084, China Department of General Surgery, The Affiliated Hospital of Nantong University, Jiangsu Province 226001, China State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, P. R. China CAS Center for Excellence in Regional Atmospheric Environment, and Key Laboratory of Urban Pollutant Conversion, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen, 361021, China; University of Chinese Academy of Sciences, Beijing, 100049, China Department of Orthopaedics, Wuhan Fourth Hospital, Puai Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China Division of Solid‐State Electronics The Ångström Laboratory Uppsala University SE‐751 21 Uppsala Sweden Tianjin Eye Hospital, Tianjin Eye Institute,Tianjin Key Laboratory of Ophthalmology and Visual Science, Tianjin, China Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; The MOE Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China Ophthalmology; State Key Laboratory of Medicinal Chemical Biology College of Pharmacy Nankai University Haihe Education Park, 38 Tongyan Road Tianjin 300353 P. R. China School of Pharmacy Nanjing University of Chinese Medicine Nanjing China; Jiangsu Key Laboratory of Chinese Medicine Processing Nanjing University of Chinese Medicine Nanjing China Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China; Fujian Normal University Center of Laboratory Medicine, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China Department of Dermatology Nanfang Hospital Southern Medical University Guangzhou Guangdong China Yonghong Zhang Family Center for Advanced Materials for Energy and Environment, Department of Earth and Environmental Engineering, Columbia University, New York, New York.; School of Chemical Engineering, Northwest University, Xi'an, China. Department of Joint and Trauma Surgery, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China Department of Medical Oncology, 900TH Hospital of Joint Logistics Support Force, Fujian Medical University; Affiliated Dongfang Hospital, Xiamen University School of Medicine; Fujian University of Traditional Chinese Medicine, Fuzhou Engineering Research Center of Polymer Green Recycling of Ministry of Education; College of Environmental Science and Engineering; Fujian Normal University; Fuzhou; China Department of Pathology Stony Brook University Stony Brook NY USA; State Key Laboratory of Quality Research in Chinese Medicine Macau University of Science and Technology Macau China College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, PR China Department of Hand and Reconstructive Microsurgery, National University Hospital, Singapore School of Chemical and Environmental Engineering; Shanghai Institute of Technology; Shanghai 201418; P. R. China State Key Laboratory of Low‐Dimensional Quantum Physics Department of Physics Tsinghua University Beijing 100084 China; Collaborative Innovation Center of Quantum Matter Beijing 100084 China Duke Human Vaccine Institute and Departments of Medicine, Pediatrics, Surgery and Immunology, Duke University School of Medicine, Durham, North Carolina 27710 Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC; Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety and the Ministry of Education (MOE) Key Lab of Environment and Health, School of Public Health, Tongji Medical College Huazhong University of Science and Technology 13 Hangkong Road Wuhan Hubei 430030 China Key Laboratory of Synthetic and Natural Functional Molecule of the Ministry of Education College of Chemistry and Materials Science Northwest University Xi'an Shaanxi 710127 P. R. China Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China; Institute of Dermatology, Shanghai Academy of Traditional Chinese Medicine, Shanghai 201203, China Department of Neurosurgery, The Second Affiliated Hospital of Kunming Medical University, Kunming 650223, Yunnan Province, China School of Stomatology Weifang Medical University Weifang Shandong China; Weifang Key Laboratory of Oral Biomedicine Weifang Medical University Weifang Shandong China Department of Infectious Disease, First Clinical Hospital of Jilin University, Changchun 130021, China. State Key Laboratory of Low-Dimensional Quantum Physics, Department of Physics, Tsinghua University, Beijing 100084, China.; Collaborative Innovation Center of Quantum Matter, Beijing 100084, China. Center for Quantitative Systems Biology and Department of Physics, Hong Kong Baptist University, Hong Kong, China. Department of Conservative Dentistry and Periodontics, Affiliated Hospital of Stomatology, Zhejiang University School of Medicine, Hangzhou, China Key Laboratory of Surface & Interface Science of Polymer Materials of Zhejiang Province, Department of Chemistry, Zhejiang Sci-Tech University, 928 Second Street, Hangzhou 310018, China Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.; Shanghai University of Traditional Chinese Medicine, Shanghai, China. Department of Adult Joint Reconstructive Surgery, Beijing Jishuitan Hospital, Capital Medical University, Beijing, China; Department of Immunology, School of Basic Medical Sciences, Peking University. NHC Key Laboratory of Medical Immunology, Peking University, Beijing, China 1National Clinical Research Center for Metabolic Diseases, Metabolic Syndrome Research Center, Key Laboratory of Diabetes Immunology, Ministry of Education, and Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China Department of Chemistry and Biochemistry, University of Texas at Austin, 1 University Station A5300, Austin, Texas 78712, United States The Genetic Engineering International Cooperation Base of the Chinese Ministry of Science and Technology, The Key Laboratory of Molecular Biophysics of the Chinese Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China State Key Laboratory of Pharmaceutical Biotechnology Collaborative Innovation Center of Chemistry for Life Sciences Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology NJU Advanced Institute for Life Sciences (NAILS) School of life sciences Nanjing University Jiangsu China Department of Neurosurgery, The Second Affiliated Hospital of Kunming Medical University, Kunming 650223, Yunnan, China Merck & Co., Inc., Kenilworth, NJ, USA Department of Cardiology, West China Hospital, Sichuan University, Chengdu 610041, China. Department of Urology, North China University of Science and Technology Affiliated Hospital, Tangshan 063000, China Xiangya School of Nursing, Central South University , Changsha, Hunan , China Tsinghua University 1 Department of Physics, , Beijing 100084, China Columbia Nanomechanics Research Center, Department of Earth and Environmental Engineering, Columbia University, New York, NY 10027, USA; International Center for Applied Mechanics, SV Laboratory, School of Aerospace, Xi'an Jiaotong University, Xi'an 710049, People's Republic of China 3Department of Public Health Sciences and the Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, Florida. Duke Human Vaccine Institute 1 , 2 , 3 , 4 , 5 , and 6; Department of Medicine 1 , 2 , 3 , 4 , 5 , and 6; Department of Pediatrics 1 , 2 , 3 , 4 , 5 , and 6; Department of Surgery 1 , 2 , 3 , 4 , 5 , and 6; Department of Immunology 1 , 2 , 3 , 4 , 5 , and 6; Center for Computational Immunology, Duke University School of Medicine, Durham, NC 27710 1 , 2 , 3 , 4 , 5 , and 6 Division of Pulmonary, Allergy, Critical Care & Sleep Medicine; Department of Molecular and Cellular Pharmacology, and National Engineering Laboratory for Industrial Enzymes, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China Zhejiang Provincial People's Hospital, Hangzhou 310014, China Neurology Department, BeiHua University Teaching Hospital , Jilin , 132011 , China Department of General Surgery The Second Affiliated Hospital of Xi'an JiaoTong University Xi'an People's Republic of China Department of Nephrology, Children’s Hospital of Nanjing Medical University, Nanjing, People’s Republic of China; Jiangsu Key Laboratory of Pediatrics, Nanjing Medical University, Nanjing, People’s Republic of China; Nanjing Key Laboratory of Pediatrics, Children’s Hospital of Nanjing Medical University, Nanjing, People’s Republic of China Institute of Automation, Chinese Academy of Sciences, Beijing 100190, P. R. China Institute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University State Key Laboratory of Physical Chemistry of Solid Surfaces, the Key Laboratory for Chemical Biology of Fujian Province, Key Laboratory of Analytical Science, Department of Chemical Biology, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, P. R. China Department of Chemistry, University of California, Davis, California 95616 c Hunan Provincial Center for Disease Control and Prevention , Changsha , Hunan , China New Drug Screening Center, Jiangsu Center for Pharmacodynamics Research and Evaluation, China Pharmaceutical University , Nanjing 210009 , China Department of Dental Ecology School of Dentistry University of North Carolina Chapel Hill NC USA Division of Education and Research, Shantou Central Hospital, Shantou 515031, China. College of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, China. College of Chemistry and Material Science, South-Central University for Nationalities, Wuhan 430074, P.R. China Key Laboratory of Medical Molecular Virology of Ministries of Education and Health, Department of Immunology, School of Basic Medical Sciences , China; Biotherapy Research Center, Fudan University , Shanghai, China Institute of Cellular and Molecular Biology, Jiangsu Normal University, Xuzhou, P. R. China Markey Cancer Center, Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, Kentucky, USA Department of Pharmacology, Beijing Key Laboratory of Drug Resistance Tuberculosis Research, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Research Institute , Beijing, China Department of Clinical and Military Laboratory Medicine, College of Medical Laboratory Science, Army Medical University, 30 Gaotanyan Street, Shapingba District, Chongqing 400038, China Department of Chemistry, Loyola Science Center, University of Scranton, Scranton, Pennsylvania. Cardeza Foundation for Hematologic Research, Department of Medicine, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA Department of Rehabilitation Medicine The First Affiliated Hospital Sun Yat‐sen University Guangzhou 510080 China Beijing Key Laboratory of Flavor Chemistry, Beijing Technology and Business University, 10048 Beijing, People’s Republic of China Department of Emergency Surgical Trauma Center, BinZhou Medical University Hospital, Binzhou 256603, China State Key Laboratory of Low‐Dimensional Quantum Physics Department of Physics Tsinghua University Beijing 100084 China; Collaborative Innovation Center of Quantum Matter Beijing 100084 P. R. China State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, No. 7 Jinsui Road, Tianhe District, Guangzhou, China; Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China College of Plant Protection, China Agricultural University Beijing China; Sanya Institute of China Agricultural University Sanya China Stem Cell and Cancer Center; First Affiliated Hospital; Jilin University; Changchun Jilin P.R. China; Stanford University Medical School; Palo Alto Veterans Institute for Research; Palo Alto California School of City Planning and Municipal Engineering, Xi'an Polytechnic University, Xi'an 710048, China. Department of Biology, Southern University of Science and Technology , Shenzhen 518055, China School of Environment, Key Laboratory for Yellow River and Huai River Water Environment and Pollution Control, Ministry of Education, Henan Normal University, Xinxiang 453007, China State Key Joint Laboratory of Environment Simulation and Pollution Control, Department of Environmental Science and Engineering, Tsinghua University, Beijing, 100084, P.R. China State Key Laboratory of Hybrid Rice, College of Life Sciences Wuhan University Wuhan 430072 China School of Life Science and Technology,Harbin Institute of Technology,Harbin,China Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China Department of Medical Oncology Sun Yat‐sen University Cancer Center Guangzhou China; State Key Laboratory of Oncology in South China Guangzhou China; Collaborative Innovation Center for Cancer Medicine Guangzhou China Key laboratory of Material Chemistry for Energy Conversion and Storage; School of Chemistry and Chemical Engineering; Huazhong University of Science and Technology; Wuhan; PR China State Key Laboratory of Bioreactor Engineering East China University of Science and Technology Shanghai China Department of Rheumatology and Immunology, Ningxia Clinical Institute of Bone and Joint Research, the Affiliated People’s Hospital of Ningxia Hui Autonomous Region, Ningxia Medical University, Yinchuan, Ningxia, China Chinese Academy of Sciences Co-Innovation Center for Sustainable Forestry in Southern China, College of Forestry, Nanjing Forestry University, Nanjing, Jiangsu 210037, China; Jiangsu Key Laboratory for Prevention and Management of Invasive Species, Nanjing Forestry University, Nanjing, Jiangsu 210037, China Department of Chemical and Biomolecular Engineering National University of Singapore 4 Engineering Drive 4 Singapore 117585 Singapore Keenan Research Centre Li Ka Shing Knowledge Institute St. Michael's Hospital Toronto Ontario Canada; Department of Laboratory Medicine and Pathobiology University of Toronto Toronto Ontario Canada; Canadian Blood Services Toronto Ontario Canada State Key Laboratory of Pharmaceutical Biotechnology, Collaborative Innovation Center of Chemistry for Life Sciences, NJU Advanced Institute for Life Sciences (NAILS), Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, School of Life Sciences, Nanjing University, Nanjing, Jiangsu 210046, China Department of Orthopaedic Surgery, Musgrave Park Hospital, Queen's University Belfast Belfast UK Department of General Surgery The Second Affiliated Hospital of Xi'an Jiaotong University Xi'an China School of Pharmaceutical Science, Shanxi Medical University, Taiyuan 030001, China Key Laboratory of Environmentally Friendly Chemistry and Application of Ministry of Education, College of Chemistry, Xiangtan University, Xiangtan 411105, P. R. China Duke University Medical Center, Durham, North Carolina, USA The MOE Key Laboratory of Spectrochemical Analysis & Instrumentation; The Key Laboratory of Chemical Biology of Fujian Province; State Key Laboratory of Physical Chemistry of Solid Surfaces; College of Chemistry and Chemical Engineering; Xiamen University Duke Human Vaccine Institute, and Department of Orthopedics, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, Anhui, China Tianjin Key Laboratory of Environment, Nutrition, and Public Health, Tianjin Medical University Department of Statistics, Stanford University, Stanford, CA 94305;; Department of Biomedical Data Science, Stanford University, Stanford, CA 94305; Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China National Key Laboratory of Science and Technology on Advanced Composites, Harbin Institute of Technology, Harbin, Heilongjiang 150001, People’s Republic of China Key Laboratory of Ruminant Disease Prevention and Control (West), College of Veterinary Medicine, Northwest A&F University, Yangling 712100, China Department of Biology, Syracuse University, Syracuse, New York 13244 State Key Laboratory of Low Dimensional Quantum Physics, Department of Physics, Tsinghua University, Beijing 100084, P. R. China. Key Laboratory of Early Prevention and Treatment for Regional High Frequency Tumor, Guangxi Medical University, Ministry of Education, Nanning, Guangxi Zhuang Autonomous Region 530021, P.R. China Neurology Department, Guangzhou First People`s Hospital, Guangzhou, China. Department of Microbe-Plant Interactions, Center for Biomolecular Interactions Bremen (CBIB), Faculty of Biology and Chemistry, University of Bremen , PO Box 330440, Bremen D-28334, Germany State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China; Department of Operative Dentistry and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China Guangzhou Center for Disease Control and Prevention, Guangzhou, China Department of Electrical Engineering, The Pennsylvania State University, University Park, Pennsylvania16802, United States Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China Center of Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University People’s Hospital , Beijing , 100044 , China State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan Province, China State Key Laboratory of Genetic Engineering, Collaborative Innovation Center of Genetics and Development, Department of Physiology and Biophysics, School of Life Sciences, Fudan University, Shanghai 200433, China College of Information Technology, Shanghai Ocean University, Shanghai 201306, P.R.China;Key Laboratory of Fisheries Information, Ministry of Agriculture, Shanghai 201306, P.R.China. College of Chemistry and Molecular Engineering; Zhengzhou University; Zhengzhou; China Authors' Affiliations: 1Department of Medicine, Division of Gastroenterology; Departments of 2Cancer Biology, 3Pathology, Microbiology, and Immunology, and 4Division of Cancer Biostatistics, Department of Biostatistics; 5Section of Surgical Sciences, Department of Surgery, Division of Surgical Oncology, Vanderbilt University School of Medicine; 6Vanderbilt Ingram Cancer Center; and 7Veterans Affairs Tennessee Valley Health Care System, Nashville, Tennessee Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences, Wuhan 430071, China; Wuhan Institute of Quantum Technology, Wuhan 430206, China; Hefei National Laboratory, Hefei 230094, China State Key Laboratory of Hydrology-Water Resources and Hydraulics Engineering, Hohai University, Nanjing 210098, China Center for Quantitative Biology, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China Institute of Grassland, Flowers and Ecology, Beijing Academy of Agriculture and Forestry Sciences, Beijing 100097, China Ontario Institute of Studies in Education; University of Toronto; Toronto ON Canada Department of Chemistry, University of California, Davis, Davis, California, USA Medical Department of Graduate School, Nanchang University, Nanchang, Jiangxi, China (mainland) Department of Orthopaedic Surgery Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China Clinical Anatomy & Reproductive Medicine Application Institute, Hengyang Medical College University of South China Hengyang Hunan China; Shaoyang First People's Hospital Graduate Joint Training Innovation Base University of South China Hengyang Hunan China College of Resource and Environment, Northeast Agricultural University, Harbin, Heilongjiang, PR China Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina; Department of Abdominal Ultrasound, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, China Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 725 Rose Street, Lexington, Kentucky 40536 College of Computer Science, Zhejiang University, Hangzhou 310027, China Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, China School of Life Science, Institute of Cellular and Molecular Biology, Jiangsu Normal University, Xuzhou, China Department of Civil and Environmental Engineering, University of Illinois at Urbana−Champaign, Urbana, Illinois 61801, United States Shandong Center for Disease Control and Prevention, and Academy of Preventive Medicine, Shandong University, Jinan, China The Second Clinical Institute of Southern Medical University, Guangzhou, China Beijing Chest Hospital Capital Medical University Beijing China; Beijing Tuberculosis and Thoracic Tumor Research Institute Beijing China State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, P.R. China State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Guangzhou Guangdong China; Department of nasopharyngeal carcinoma Sun Yat‐sen University Cancer Centre Guangzhou Guangdong China Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China The Second Affiliated Hospital and Life Sciences Institute and School of Medicine, The Ministry of Education Key Laboratory of Biosystems Homeostasis and Protection and Zhejiang Provincial Key Laboratory for Cancer Molecular Cell Biology, Zhejiang University, Hangzhou 310058, China Institute of Stem Cell and Tissue Engineering, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China. National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing, China Boston Scientific Corporation, CA, USA Department of Pharmacology, School of Basic Medicine, Tongji Medical College Huazhong University of Science and Technology Wuhan China *Institute of Health Sciences, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences and Shanghai JiaoTong University School of Medicine, Shanghai, China; and Department of Chemistry, University of California, One Shields Avenue, Davis, California 95616 Department of Otorhinolaryngology First Affiliated Hospital of Nanjing Medical University Nanjing China Medical Department, Graduate School, Nanchang University, Nanchang, Jiangxi, China (mainland) Department of Human Nutrition, Kansas State University, Manhattan, KS 66506, USA Department of Statistics, Stanford University, Stanford, CA 94305; Department of Molecular and Cellular Biochemistry, ‡Department of Surgery, College of Medicine, §Department of Pharmaceutical Sciences, College of Pharmacy, ∥Center for Pharmaceutical Research and Innovation, and ⊥Markey Cancer Center, University of Kentucky, Lexington, Kentucky 40506-0509, United States Department of Otolaryngology-Head and Neck Surgery, Navy General Hospital Beijing 100048, China. Chemical Genomics Centre of the Max Planck Society Otto‐Hahn‐Str. 15 44227 Dortmund Germany; Max‐Planck‐Institute of Molecular Physiology Otto‐Hahn‐Str. 11 44227 Dortmund Germany Institute of Automation; Chinese Academy of Sciences; Beijing; China State-key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China; Department of Pathology, College of Veterinary Medicine, University of Georgia, Athens, GA, USA National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, Beijing 100050, China. College of Safety and Emergency Management Engineering, Taiyuan University of Technology, Taiyuan 030600, China College of Photonic and Electronic Engineer, Fujian Normal University, Fuzhou 350117, China Department of Chemical and Biomolecular Engineering National University of Singapore 4 Engineering Drive 4 117576 Singapore Reproductive Medical Centre, Renmin Hospital of Wuhan University, Wuhan, China Department of Pediatrics, Divisions of Pediatric Hematology/Oncology and Medical Genetics, Massachusetts General Hospital, Boston, MA; Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China Department of Rehabilitation Medicine, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China. Department of Pediatrics, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China Key Laboratory of Pesticide & Chemical Biology of the Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, P. R. China; Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 789 South Limestone Street, Lexington, Kentucky 40536, United States State Key Laboratory of Pharmaceutical Biotechnology, Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, NJU Advanced Institute for Life Sciences (NAILS), School of Life Sciences, Nanjing University, Nanjing, Jiangsu 210046, China Department of Pharmacy, The Second Affiliated Hospital of Air Force Medical University, Xi’an, China Arthritis Clinic and Research Center, Peking University People's Hospital, Beijing 100044, China. Department of Chemistry; University of Manchester; Manchester; UK Dementia Centre for Research Collaboration Department of Chemical and Biomolecular Engineering University of California – Los Angeles Los Angeles California USA Department of Earth and Environmental Engineering Columbia University New York NY 10027 USA State Key Laboratory of Pharmaceutical Biotechnology, Department of Gastroenterology, Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, 210093 Nanjing, China; Department of Plastics & Cosmetic, The Eye Hospital of Wenzhou Medical University, Wenzhou City, People’s Republic of China Ministry of Education Key Laboratory of Molecular and Cellular Biology, Hebei Anti-Tumor Molecular Target Technology Innovation Center, College of Life Science, Hebei Normal University, Shijiazhuang 050024, China 2Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee; Center for Neurodegenerative Science, Van Andel Research Institute, Grand Rapids, MI, USA Freshwater Fisheries Research Center, Chinese Academy of Fishery Sciences Wuxi China; Key Laboratory of Fishery Eco‐environment Assessment and Resource Conservation in Middle and Lower Reaches of the Yangtze River, CAFS Wuxi China Department of Gastroenterology, The Seventh Medical Center of PLA General Hospital, Beijing, China Institute of Cellular and Molecular Biology, Jiangsu Normal University, Xuzhou, China Department of Obstetrics, Gynecology & Reproductive Sciences, University of Maryland School of Medicine, Baltimore, Maryland. National Engineering Laboratory for Industrial Enzymes and Tianjin Engineering Research Center of Biocatalytic Technology Tianjin Institute of Industrial Biotechnology Chinese Academy of Sciences, and National Technology Innovation Center for Synthetic Biology Tianjin 300308 China Department of Chemistry, The University of Manchester, Manchester M13 9PL, United Kingdom Hospital of Stomatology, Sun Yat-sen University, Guangzhou 510055, China; Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510055, China; South China Center of Craniofacial Stem Cell Research, Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou 510055, China Email: 13916511683@163.com. College of Computer Science and Software Engineering, Shenzhen University, Shenzhen, China Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina; and The Affiliated Hospital of Medical College, Ningbo University, Ningbo, China State Key Laboratory of Pharmaceutical Biotechnology Collaborative Innovation Center of Chemistry for Life Sciences Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology Nanjing Advanced Institute for Life Sciences (NAILS) School of Life Sciences Nanjing University 163 Xianlin Avenue Nanjing 210023 P. R. China Department of Gynecology The First Affiliated Hospital of China Medical University Shenyang China Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas Department of Respiratory Diseases, First Affiliated Hospital, College of Medicine, Zhejiang University, Zhejiang University, Hangzhou, People’s Republic of China. 19Medical Oncology, 900 Hospital of the Joint Logistics Support Force, Fuzhou, China. Department of Earth and Environmental Engineering, Columbia University, New York, New York 10027, United States Authors' Affiliations: Departments of 1Pharmacology, 2Biochemistry, and 3Pathology, The University of Alabama at Birmingham; 4Drug Discovery Division, Southern Research Institute, Birmingham; 5Department of Biology, Chemistry, and Mathematics, University of Montevallo, Montevallo; 6Drug Discovery Research Center, Mitchell Cancer Institute, University of South Alabama, Mobile, Alabama; and 7Faculty of Pharmacy and Biotechnology, German University of Cairo, Cairo Egypt Molecular Biophysics and Integrated Bioimaging, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA; Helen Wills Neuroscience Institute, University of California Berkeley, Berkeley, CA 94720, USA Department of Neurology and China-America Institute of Neuroscience, Xuanwu Hospital, Beijing Institute of Brain Disorders, Capital Medical University, Beijing, China Center for Air Resources Engineering and Science (CARES), Clarkson University, Potsdam, New York 13699-5708, United States and College of Engineering, Center for Environmental Research and Technology (CERT), University of California, Riverside, California 92521, United States Department of Otolaryngology Head and Neck Surgery, Navy General Hospital, Beijing 100048, China. State Key Laboratory of Proteomics,Beijing Proteome Research Center, Beijing Institute of Radiation Medicine,Beijing,China Department of Ophthalmology, Duke University, Durham, NC, USA Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China. University of Chinese Academy of Sciences, Beijing, China. College of Plant Protection, China Agricultural University, No. 2 Yuanmingyuan West Road, Beijing 100193, China Department of Colorectal Surgery, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou 510655, China. Department of Chemistry, One Shields Avenue, University of California—Davis, Davis, California 95616, United States State Key Laboratory of Explosion Science and Technology, Beijing Institute of Technology, No.5, Zhongguancun South Street, Haidian District, Beijing 100081, China School of Stomatology, Weifang Medical University, Weifang, Shandong 261000, P.R. China Department of Chemistry and Biochemistry, University of Arizona, 1306 East University Boulevard, Tucson, Arizona 85721, United States State Key Laboratory of Desert and Oasis Ecology, Xinjiang Institute of Ecology and Geography, Chinese Academy of Sciences, No. 818 South Beijing Road, Urumqi, Xinjiang 830011, China National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China Henan Key Laboratory of Child Brain Injury Institute of Neuroscience Third Affiliated Hospital of Zhengzhou University Zhengzhou China Department of Food Science, Rutgers University, New Brunswick, New Jersey 08901, United States Department of Public Health Sciences, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.; Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL 33136, USA. Department of Integrated Care Management Center, West China Hospital, Sichuan University/West China School of Nursing, Sichuan University, Chengdu 610041, China. School of Sports Science, Wenzhou Medical University, Wenzhou, Shanghai, China Department of Materials Science and Engineering, Drexel University, Philadelphia, Pennsylvania 19104, United States Department of Biochemistry and Molecular Biology, College of Basic Medicine, China Medical University, Shenyang 110122, China Department of Obstetrics and Gynecology, Department of Gynecologic Oncology Research Office, Guangdong Provincial Key Laboratory of Major Obstetric Diseases The Third Affiliated Hospital of Guangzhou Medical University Guangzhou China Department of Stomatology, the First Affiliated Hospital, Medical School of Xi'an Jiaotong University, Xi'an 710061, China chen168_xi@163.com. Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China Department of Medical Oncology Sun Yat‐Sen University Cancer Center State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Guangzhou China Department of Chemistry, University of California, Davis, California, USA Hunan Province Innovative Training Base for Medical Postgraduates Hengyang Medical School, University of South China and Yueyang Women & Children's Medical Center Yueyang Hunan 416000 China; Clinical Anatomy & Reproductive Medicine Application Institute Hengyang Medical School University of South China Hengyang Hunan 421001 China Department of Neurology, the First Affiliated Hospital, San Yat-sen University, Guangzhu, Guangdong, 510080 PR China. chenxi73@163.com Department of Chemistry, Capital Normal University, Beijing 100048, China. State Key Laboratory of Desert and Oasis Ecology, Xinjiang Institute of Ecology and Geography, Chinese Academy of Sciences, Urumchi, 830011, P.R. China; Xinjiang Institute of Ecology and Geography, Chinese Academy of Sciences, Urumchi, 830011, P.R. China School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, People's Republic of China Orthopedics 1State Key Laboratory of Pharmaceutical Biotechnology, Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, NJU Advanced Institute for Life Sciences, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, China. Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX Authors' Affiliations: 1Glycobiology Research and Training Center and the Moores Cancer Center, University of California at San Diego; 2Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla; 3Sialix, Inc., Vista; and 4Department of Chemistry, University of California-Davis, Davis, California Department of Otorhinolaryngology Guangzhou Women and Children's Medical Center Guangzhou Medical University Guangzhou China Department of Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China. Department of Obstetrics and Gynecology, Department of Gynecologic Oncology Research Office, Key Laboratory for Major Obstetric Diseases of Guangdong Province The Third Affiliated Hospital of Guangzhou Medical University Guangzhou China School of Software, Zhengzhou University, Zhengzhou, Henan 450002, China; Collaborative Innovation Center for Internet Healthcare, Zhengzhou University, Zhengzhou, Henan 450052, China SpecAlly Life Technology Co., Ltd., Wuhan, P. R. China; Medical Research Institute, Wuhan University, Wuhan, P. R. China McLean Imaging Center, McLean Hospital, Harvard Medical School 1 , Belmont, MA ;; Psychotic Disorders Division, McLean Hospital, Harvard Medical School 2 , Belmont, MA ; Medical Department of Graduate School, Nanchang University, Nanchang Department of Dental Ecology University of North Carolina Chapel Hill North Carolina Department of Materials Science and Engineering Drexel University Philadelphia Pennsylvania 19104 The First Affiliated Hospital, Sun Yat-sen University Department of Rehabilitation Medicine, , Guangzhou 510080 , China Institute of Combined Injury, State Key Laboratory of Trauma, Burns and Combined Injury, Chongqing Engineering Research Center for Nanomedicine, College of Preventive Medicine, Chongqing Engineering Research Center for Biomaterials and Regenerative Medicine, Third Military Medical University, Chongqing 400038, China Key Laboratory of Analytical Sciences of MOE, Department of Chemistry, Xiamen University, Xiamen 361005, China. Key Laboratory of Pesticide and Chemical Biology of the Ministry of Education of China, College of Chemistry, Central China Normal University, Wuhan 430079, P. R. China, and Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 725 Rose Street, Lexington, Kentucky 40536 College of Traditional Medicine Guangdong Pharmaceutical University Guangzhou 510006 China; Department of Chemistry Shantou University Shantou 515063 China Department of Orthopedic Surgery, Peking Union Medical College Hospital Peking Union Medical College, Chinese Academy of Medical Sciences Beijing China; Department of Orthopedics, West China Hospital, West China School of Medicine Sichuan University Chengdu China Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, Hunan, P.R. China Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China Laboratory of Mucosal Immunology, Affiliated Stomatology Hospital of Guilin Medical University, Guilin, Guangxi 541004, P.R. China ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, and the Department of Chemical and Biomolecular Engineering, The University of Melbourne, Parkville, Victoria 3010, Australia State Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry, the Chinese Academy of Sciences, Shanghai 200031, China. jychen@sunm.shcnc.ac.cn Department of Management Science and Engineering Stanford University Stanford CA 94305 USA School of Integrated Circuits, Huazhong University of Science and Technology, Wuhan 430074, P. R. China Department of Dermatology, Chongqing Hospital of Traditional Chinese Medicine, Chongqing 400021, China Department of Dermatology Peking University First Hospital Beijing China; National Clinical Research Center for Skin and Immune Diseases Beijing China; Beijing Key Laboratory of Molecular Diagnosis on Dermatoses Beijing China; National Medical Products Administration Key Laboratory for Quality Control and Evaluation of Cosmetics Beijing China Department of Physics, Tsinghua University, Beijing 100084, China Vollum Institute, Oregon Health and Science University, Portland, OR 97239; Department of Chemistry and the MOE Key Laboratory of Spectrochemical Analysis & Instrumentation; College of Chemistry and Chemical Engineering; Xiamen University; Xiamen 361005; China Center for Arrhythmia Research, University of Michigan, Ann Arbor, MI Department of Chemistry, Wayne State University Detroit, Michigan 48202 College of Forestry, Northeast Forestry University, Harbin 150040, China. Department of Ophthalmology, The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, People’s Republic of China Freshwater Fisheries Research Center, Chinese Academy of Fishery Sciences, Scientific Observing and Experimental Station of Fishery Resources and Environment in the Lower Reaches of the Yangtze River, Wuxi 214081, China Hunan Provincial Center for Disease Control and Prevention, Changsha, China Department of Nuclear Medicine, The Affiliated Hospital of Southwest Medical University, Luzhou, China; Nuclear Medicine and Molecular ImagingKey Laboratory of Sichuan Province, Luzhou, China; Institute of Nuclear Medicine, Southwest Medical University, Luzhou, China Department of Rehabilitation Medicine, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou 510630, China Medical Research Institute, Wuhan University, Wuhan 430072, China; SpecAlly Life Technology Co., Ltd., Wuhan 430072, China Department of Chemistry and Biochemistry, Institute for Cell and Molecular Biology, University of Texas at Austin, Austin, Texas 78712 Division of Biostatistics, Department of Public Health Sciences, University of Miami Miller School of Medicine, Miami, FL 33136, USA; Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33136, USA Department of Communication Engineering Xiamen University Xiamen China BIC-ESAT and SKL-ESPC, College of Environmental Sciences and Engineering, Center for Environment and Health (Y.X., Y.H., Y.W., J.G., H.L., T.W., X.C., W.C., Y.F., X.Q., J.W., T.Z.), Peking University, Beijing, China. Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Shanghai Jiao Tong University School of Medicine, Shanghai, 200031, China Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China Earth Engineering Center Center for Advanced Materials for Energy and Environment Department of Earth and Environmental Engineering Columbia University New York NY 10027 USA College of Chemistry and Material Sciences, South-Central University for Nationalities, Wuhan, P.R. China Applied Physics University of Michigan Ann Arbor MI 48109 USA for the Jing-Jin-Ji Esophageal and Esophagogastric Cancer Radiotherapy Oncology Group (3JECROG) School of Materials Science and Engineering, Harbin Institute of Technology (Shenzhen), Shenzhen, Guangdong 518055, China BGI Education Center, University of Chinese Academy of Sciences, Shenzhen, China and; BGI-Shenzhen, Shenzhen, China College of Basic Medicine, Beihua University, Jilin, China Department of Pharmacy The Second Affiliated Hospital of Air Force Medical University Xi’an PR China Department of General Surgery, The Second Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an, Shaanxi 710004, P.R. China School of Information and Communications Engineering, Xi'an Jiaotong University, Shaanxi 710049, China College of Life Sciences, Nanjing Agricultural University, Nanjing 210095, China Department of Biology, New York University, New York, NY 10003, USA School of Intelligent Systems Engineering, Sun Yat-sen University, Shenzhen 510275, China State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China Department of General Surgery,The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an Jiaotong University,Xi'an,PR China Sichuan College of Traditional Chinese Medicine Mianyang People's Republic of China Department of Obstetrics and Gynaecology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing 210009, China Department of Microbe‐Plant Interactions CBIB (Center for Biomolecular Interactions Bremen) University of Bremen PO Box 330440 D‐28334 Bremen Germany Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province Sichuan Agricultural University Chengdu China Institute of Neurology, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu 611731, China; Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital, Chengdu 611731, China The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, Center for Information in Medicine, School of life Science and Technology, University of Electronic Science and Technology of China, Chengdu P. R. China Department of Chemistry, University of California, Davis, CA 95616; School of Pharmaceutical Sciences, Liaocheng University, 1 Hunan Street, Liaocheng 252059, China Mechanical Engineering, Indiana University-Purdue University Indianapolis 1 , 723 W Michigan St., Indianapolis, Indiana 46202, USA; Mechanical Engineering, Purdue University 2 , 585 Purdue Mall, West Lafayette, Indiana 47907, USA College of Pharmacology, Guangxi Medical University, 22 ShuangYong Road, Nanning 530200, China Binhai Genomics Institute, BGI-Tianjin, BGI-Shenzhen, Tianjin 300308, China; Tianjin Translational Genomics Center, BGI-Tianjin, BGI-Shenzhen, Tianjin 300308, China Center for Nano Science and Technology College of Chemistry and Material Science The Key Laboratory of Functional Molecular Solids Ministry of Education Anhui Laboratory of Molecule-Based Materials Anhui Normal University Beijing east Road 1 Wuhu China 1Drug Discovery Research Center, Mitchell Cancer Institute, University of South Alabama, Mobile, Alabama. Department of Molecular and Cellular Biology, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138 Department of Nursing Yancheng NO.1 People's Hospital Jiangsu P. R. China First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China; National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, China Department of Chemistry, University of California, Davis, California 95616, United States Neurogen Corporation, 35 Northeast Industrial Road, Branford, Connecticut 06405 Department of Chemistry, Texas A&M University, 580 Ross Street, College Station, Texas 77843, United States Department of Oncology, Tumor Hospital Affiliated to Nantong University, Jiangsu, China The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei 230038, China College of Veterinary Medicine Huazhong Agricultural University Wuhan China State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy Sun Yat‐Sen University Cancer Center Guangzhou China; Department of Nasopharyngeal Carcinoma Sun Yat‐Sen University Cancer Center Guangzhou China Chinese Academy of Inspection and Quarantine, No. 3 Gaobeidian North Rd 100123, Chaoyang District, Beijing, People’s Republic of China Department of Medical Oncology, Fuzhou General Hospital of Nanjing Military Command, Fuzong Clinical College of Fujian Medical University, Fujian - PR China From the State Key Laboratory of Cardiovascular Disease, Sino-German Laboratory for Molecular Medicine (Y.W., J.C., Y.Z., W.Y., C.Z., L.G., L.S., R.H.), Department of Radiology (J.L., Y.G.), and Department of Laboratory Medicine (Xuannan Chen, Xi Chen), Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. Pathogen Biology Department, College of Basic Medicine, Beihua University, Jilin, China Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, PR China Department of Otolaryngology, Affiliated First Hospital, Fujian Medical University, Fuzhou 350005. Department of Cardiology, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Department of Orthopaedic Surgery Peking Union Medical College Hospital,Chinese Academy of Medical Sciences(CAMS) Beijing China Key Lab of Organic Optoelectronics and Molecular Engineering of Ministry of Education Department of Chemistry Tsinghua University 100084 Beijing China Department of Urology, Tongji Hospital, School of Medicine, Tongji University Shanghai, The People's Republic of China. Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, MA, USA Department of Preventive and Community Dentistry University of Iowa Iowa City Iowa Department of Materials Science and Engineering, North Carolina State University, Raleigh, North Carolina27695, United States Department of Otorhinolaryngology Head and Neck Surgery, the First Affiliated Hospital of Fujian Medical University, Fuzhou, 350005, China. Department of Pathology, Second Affiliated Hospital of Chongqing Medical University, Chongqing, PR China From the Center for Vital Longevity (M.E.F., X.C., M.M.R., M.Y.C., G.S.W., D.C.P.), School of Behavioral and Brain Sciences, University of Texas at Dallas; and Department of Psychiatry (G.S.W., D.C.P.), University of Texas Southwestern Medical Center, Dallas. Institute of Biomedical and Health Engineering, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China School of Computer Science, Wuhan University, Wuhan, Hubei 430072, P. R. China Department of Molecular Biology and Microbiology, and Genetics Program, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA School of Materials Science and Engineering, Harbin Institute of Technology (Shenzhen), Shenzhen 518055, China From the Department of Orthopedic Surgery, Electron Microscope Laboratory, and Department of Neuropsychiatry, Keio University School of Medicine; Graduate School of Pure and Applied Sciences, University of Tsukuba; and Polymers and Biomaterials Field, Research Center for Functional Materials, National Institute for Materials Science. State Key Laboratory and Institute of Elemento-Organic Chemistry College of Chemistry Nankai University Tianjin 300071 China Institute of Cellular and Molecular Biology, School of Life Science, Jiangsu Normal University, Xuzhou 221116, China Department of Breast Surgery General Surgery Qilu Hospital of Shandong University Ji'nan Shandong 250012 P. R. China Department of Epidemiology, Navy Medical University, Shanghai, PR China Department of Orthopedic Surgery, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Science, Beijing, China Department of Chemistry and ‡Department of Physics, Nanoscience Center, University of Jyväskylä, FI-40014 Jyväskylä, Finland Department of Vascular Surgery, Wuhan No.1 Hospital, WuHan, HuBei 430022, China Departments of Anatomy University of South China Hengyang City Hunan Province 421001 PRC State Key Laboratory of Desert and Oasis Ecology, Xinjiang Institute of Ecology and Geography, Chinese Academy of Sciences, Urumchi, 830011, P.R. China, Department of Biological Sciences, National University of Singapore, Singapore; Gene Regulation Laboratory, Genome Institute of Singapore, Singapore Department of Biomedical Engineering University of Melbourne Melbourne Victoria 3010 Australia Department of Orthopedics People’s Hospital of Deyang City China Department of Pathology and Key Laboratory for Xinjiang Endemic and Ethnic Diseases, Shihezi University School of Medicine, Shihezi, China Eye Hospital and School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, Zhejiang, China State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, Nankai University, Haihe Education Park, Tianjin 300353, People’s Republic of China Center for Quantitative Biology; Academy for Advanced Interdisciplinary Studies; Peking University; China Syngenta Biotechnology (China) Co., Ltd. Beijing China Biological Research Institute of Chenzhou, Chenzhou 423000, Hunan, China. Department of Respiratory Medicine, Xiangya Hospital of Central South University, Changsha, Hunan 410008, P.R. China Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas 77555; Sealy Center for Cancer Cell Biology, University of Texas Medical Branch, Galveston, Texas 77555 Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College Huazhong University of Science and Technology Wuhan China Department of Hematology, The Second Affiliated Hospital, Harbin Medical University, Harbin, People’s Republic of China CAS Key Laboratory of Organic Solids Institute of Chemistry Chinese Academy of Sciences Beijing 100190 P. R. China; University of Chinese Academy of Sciences Beijing 100049 P. R. China College of Mechanical Engineering, Hunan Institute of Science and Technology, Yueyang, 414006, China; Institute of New Energy, Hunan Institute of Science and Technology, Yueyang, 414006, China College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China Centre for Micro‐Photonics, Faculty of Science Engineering and Technology Swinburne University of Technology Hawthorn Victoria 3122 Australia Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, China; Key Laboratory of Hubei Province for Digestive System Disease, Renmin Hospital of Wuhan University, Wuhan, China; Hubei Provincial Clinical Research Center for Digestive Disease Minimally Invasive Incision, Renmin Hospital of Wuhan University, Wuhan, China Department of Chemistry, University of California, Riverside, California 92521, and Department of Chemistry, University of California, Davis, California 95616 Research Center for Cardiac Regenerative Medicine, The Ministry of Health, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of China. The Key Laboratory of Environmental Change and Natural Disaster, MOE Beijing Normal University Beijing China; Academy of Disaster Reduction and Emergency Management, Ministry of Emergency Management & Ministry of Education, Faculty of Geographical Science Beijing Normal University Beijing China Department of Medical Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, PR China Jiangsu Engineering Research Center for microRNA Biology and Biotechnology, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University School of Life Sciences, Nanjing, Jiangsu 210093, China The Hong Kong Polytechnic University Department of Hepatobiliary and Pancreatic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, China Beijing Key Laboratory of Drug Resistance Tuberculosis Research, Beijing Tuberculosis and Thoracic Tumor Research Institute, and Beijing Chest Hospital, Capital Medical University, Beijing, China College of Environmental Science and Engineering, China West Normal University, Nanchong 637009, China State Key Laboratory of Microbial Resources Pathology Department, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Taizhou, 317000 Zhejiang, China; Pathology Department, Enze Hospital, Taizhou Enze Medical Center (Group), Taizhou, 318050 Zhejiang, China State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou 350002, People’s Republic of China; University of Chinese Academy of Sciences, Beijing 100049, People’s Republic of China Department of Thoracic Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), Department of Chemistry, Wuhan University, Wuhan 430072, P.R. China Chemical Genomics Centre of the Max Planck Society, Otto-Hahn-Str. 15, 44227 Dortmund, Germany Department of SurgeryDepartment of PathologyDepartment of NeurologyCollege of Physicians and SurgeonsColumbia University New York NY 10032 Department of Chemistry and ‡Department of Molecular and Cellular Biology, University of California-Davis, One Shields Avenue, Davis, California 95616, United States Department of Neurology, Guangdong Neuroscience Institute, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, Guangdong Province, China; Shantou University Medical College, Shantou, Guangdong Province, China Transgenics Section Laboratory of Neurogenetics National Institute on Aging National Institutes of Health Bethesda MD USA Department of Chemistry, University of California, Davis; and Department of Chemistry Simon Fraser University 8888 University Drive Burnaby British Columbia V5A 1S6 Canada First School of Clinical Medicine, Henan University of Chinese Medicine, Zhengzhou, Henan, People's Republic of China Duke Human Vaccine Institute, Durham, North Carolina, USA State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Sun Yat‐sen University Cancer Center Guangzhou China Department of Physiology, Emory University School of Medicine, Atlanta, GA, USA Department of Orthopaedics People’s Hospital of Deyang City Deyang Sichuan China John A. Paulson School of Engineering and Applied Sciences Harvard University Cambridge MA 02138 USA National Laboratory of Pattern Recognition Institute of Automation Chinese Academy of Sciences Beijing 100190 P. R. China College of Life Science and Technology, Southwest University for Nationalities, Chengdu, PR China Tianjin Key Laboratory of Ophthalmology and Visual Science, Tianjin Eye Institute, Tianjin Eye Hospital, Tianjin, China; Nankai University Affiliated Eye Hospital, Nankai University, Tianjin, China; Clinical College of Ophthalmology, Tianjin Medical University, Tianjin, China Department of Hepatobiliary & Pancreatic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, PR China; Clinical Medicine Research Center for Minimally Invasive Procedure of Hepatobiliary & Pancreatic Diseases of Hubei Province, Wuhan, Hubei, PR China State Key Laboratory of Pharmaceutical Biotechnology, Collaborative Innovation Center of Chemistry for Life Sciences, Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, NJU Advanced Institute for Life Sciences (NAILS) School of Life Sciences, Nanjing University Nanjing China State Key Laboratory of Pharmaceutical Biotechnology, NJU Advanced Institute for Life Sciences (NAILS), Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, School of Life Sciences Nanjing University Nanjing China Department of Biomedical Sciences, City University of Hong Kong, Kowloon Tong, Hong Kong;; City University of Hong Kong Shenzhen Research Institute, 518057 Shenzhen, China; CAS Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China; School of Chemical Sciences, University of Chinese Academy of Sciences, Beijing 100049, P. R. China Department of Public Health, Zhejiang University, Hangzhou, Zhejiang, China Hunan Province CDC, ChaSa, Chang Sha, China. School of Information Science and Technology, Fudan University, Shanghai, China Chemical Genomics Centre of the Max Planck Society; 44227 Dortmund; Germany; Max-Planck Institute for Molecular Physiology; 44227 Dortmund State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou City, China Department of Epidemiology, Second Military Medical University, Shanghai 200433, China Key Laboratory of Catalysis and Energy Materials Chemistry of Ministry of Education & Hubei Key Laboratory of Catalysis and Materials Science, South-Central Minzu University, Wuhan 430074, China School of Basic Medical Sciences, Anhui Medical University, Hefei, Anhui 230032, P.R. China State Key Laboratory of Pharmaceutical Biotechnology, Collaborative Innovation Center of Chemistry for Life Sciences, Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, NJU Advanced Institute for Life Sciences (NAILS), School of Life Sciences, Nanjing University, Nanjing, Jiangsu, China College of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, China Department of Radiology, Huashan Hospital, Fudan University, Shanghai, China Department of General Surgery, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an Jiaotong University, PR China Beijing Key Laboratory on Drug-Resistant Tuberculosis Research, Beijing Tuberculosis and Thoracic Tumor Institute, Beijing Chest Hospital, Capital Medical University, Beijing, China. Institute for Environmental Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104; and University of California 2 Department of Chemistry, , One Shields Avenue, Davis, California 95616, USA Plastic, Reconstructive and Hand Surgery Service, Lausanne University Hospital, University of Lausanne, CH-1011 Lausanne, Switzerland Hunan Provincial Control of Disease and Prevention, Changsha 410005, China. School of Medicine, Nankai University, 300071 Tianjin, China; Key Laboratory of Carbon Materials of Zhejiang Province, College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325035, P. R. China Beijing Jiaotong University The National Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan 430070, China; Hubei Hongshan Laboratory, Huazhong Agricultural University, Wuhan 430070, China; College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China; Hubei International Scientific and Technological Cooperation Base of Veterinary Epidemiology, Huazhong Agricultural University, Wuhan 430070, China; Key Laboratory of Development of Veterinary Diagnostic Products, Ruminant Bio-Products, Ministry of Agriculture and Rural Affairs, Huazhong Agricultural University, Wuhan 430070, China Research Center for Ecology and Environment of Central Asia, Chinese Academy of Sciences, Urumqi, China; Key Laboratory of Biogeography and Bioresource in Arid Land, Xinjiang Institute of Ecology and Geography, Chinese Academy of Sciences, Urumqi, China Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA Department of Neurology, Affiliated Hospital of Beihua University, Jilin 132000, P.R. China Binhai Genomics Institute, BGI-Tianjin, Tianjin, China; Tianjin Translational Genomics Center, BGI-Tianjin, Tianjin, China Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Province, China. Department of Chemistry; University of California; One Shields Avenue; Davis; USA Henan Key Laboratory of Organic Functional Molecules and Drug Innovation, Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals, School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, Henan 453007, China BGI Research , Beishan Industrial Zone, Yantian District, Shenzhen 518083 , China Central Laboratory, People’s Hospital of Baoan District, Shenzhen, China State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou City, China Department of Spine Surgery, Drum Tower Hospital Medical School of Nanjing University Nanjing China Reproductive Medical Center, Department of Obstetrics and Gynecology, Peking University People’s Hospital, Beijing 100044, China Department of Laboratory Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China National Institutes for Food and Drug Control, Beijing 102629, China; YanTai University, Shandong 264005, China Authors' Affiliations: 1Instituto de Biología Molecular y Celular del Cáncer, CSIC-Universidad de Salamanca; 2Hospital Universitario de Salamanca, Salamanca, Spain; Departments of 3Medicinal Chemistry and 4Translational Development, Celgene, Summit, New Jersey Henan Key Laboratory of Engineering Antibody Medicine, Henan International United Laboratory of Antibody Medicine, Key Laboratory of Cellular and Molecular Immunology, Medical College of Henan University, Kaifeng 475004, China. Fu Foundation School of Engineering and Applied Science, Columbia University, New York, New York 10027 2State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, P. R. China. School of Chemical and Environmental Engineering, Shanghai Institute of Technology, Shanghai 201418, People’s Republic of China Huaqiao University School of Pharmaceutical Science, Hunan University of Medicine, Huaihua 418000, P. R. China Hunan Provincial Center for Disease Prevention and Control Changsha China 1Shenzhen Research Institute, The Hong Kong Polytechnic University, Shenzhen, China; 2Research Institute of Smart Ageing, The Hong Kong Polytechnic University, Hong Kong, China; 3Department of Biomedical Engineering, The Hong Kong Polytechnic University, Hong Kong, China Department of General Surgery Second Affiliated Hospital of Medical College Xi'an Jiaotong University Xi'an China Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, Maryland 21201, Radiation Oncology Research Laboratory, Department of Radiation Oncology, School of Medicine, University of Maryland, Baltimore, Maryland 21201, University of Maryland Marlene and Stewart Greenebaum Cancer Center, School of Medicine, University of Maryland, Baltimore, Maryland 21201, Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, Missouri... State Key Laboratory of Physical Chemistry of Solid Surfaces MOE Key Laboratory of Spectrochemical Analysis and Instrumentation College of Chemistry and Chemical Engineering College of Energy iChEM Department of Physics State Key Laboratory of Marine Environmental Science Xiamen University Xiamen 361005 China Department of Chemistry, University of California, Davis, CA, USA Department of Medical Oncology, Fuzhou General Hospital of Nanjing Military Command, Fuzhou, Fujian, China (mainland) Jiangsu Key Laboratory of TCM Evaluation and Translational Research China Pharmaceutical University Nanjing PR China State Key Laboratory of Rice Biology & Ministry of Agricultural and Rural Affairs Key Laboratory of Molecular Biology of Crop Pathogens and Insect Pests, Institute of Insect Sciences, Zhejiang University, Hangzhou 310058, China GEIRI North America San Jose CA 95134 USA Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts 02111,1 and |
Total number of triples: 1000.