http://rdf.ncbi.nlm.nih.gov/pubchem/author/MD5_0357e9daf816a3208b712f957e2e8334
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Predicate | Object |
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family-name | Rader |
name | Daniel J Rader Daniel J. Rader |
given-name | Daniel J Daniel J. |
organization-name | From the Division of Cardiology, Department of Medicine, Columbia University Medical Center, New York (H.Z., J.S., M.A.H., C.X., R.C.B., M.P.R.); Irving Institute for Clinical and Translational Research, Columbia University, New York (H.J., M.P.R.); Cardiovascular Institute, Perelman School of Medicine (W.L.), Division of Translational Medicine and Human Genetics, Departments of Genetics and Medicine, Perelman School of Medicine (J.T., J.B., M.C.P., D.J.R.), and Metabolic Tracer Resource, Institute... From the Division of Gastroenterology, Hepatology and Nutrition (G.L.W., S.H., M.C.P., G.H.R.), The Children's Hospital of Philadelphia, Philadelphia, PA; Institute for Translational Medicine and Therapeutics (A.W., J.B., D.J.R.), University of Pennsylvania School of Medicine, Philadelphia, PA. University of Pennsylvania, Philadelphia, Pennsylvania From the University of Pennsylvania School of Medicine, Philadelphia. Department of Medicine, Division of Translational Medicine and Human Genetics Perelman School of Medicine, University of Pennsylvania Philadelphia Pennsylvania USA From the Saha Cardiovascular Research Center and Department of Physiology, University of Kentucky, Lexington (A.D.); Department of Medicine and Robarts Research Institute, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada (R.A.H.); Department of Medicine, University of North Carolina at Chapel Hill (N.M.); Departments of Medicine and Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia (D.J.R.); Diabetes Research Program,... From the Institute for Translational Medicine and Therapeutics, Cardiovascular Institute, and Institute for Diabetes, Obesity, and Metabolism, University of Pennsylvania School of Medicine, Philadelphia. From the Laboratory of Lipids and Lipoproteins, Department of Clinical Biochemistry, Faculty of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina (V.M., L.S., L.C., A.I.G., G.B.); Institute for Translational Medicine and Therapeutics, School of Medicine, University of Pennsylvania, Philadelphia, PA (M.G.M., J.B., D.J.R.); Kidney Disease Center and Arterial Hypertension (CEREHA), Buenos Aires, Argentina (A.E.); and Lilly Research Laboratories, Eli Lilly and Company,... From the Departments of Genetics and Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia. From Institution for Translational Medicine and Therapeutics (K.K., G.C.M., D.H.M., D.J.R.) and Gene Therapy Program, Division of Medical Genetics (G.G., J.M.W.), Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pa. From Institute for Translational Medicine and Therapeutics (M.C., J.S.M., D.C., I.F., D.J.R.), University of Pennsylvania School of Medicine, Philadelphia, Pa; Division of Gastroenterology, Hepatology, and Nutrition (S.L.-K., M.d.l.L.-M., G.H.R., M.C.P.), Children’s Hospital of Philadelphia, Philadelphia, Pa. Department of Medicine (M.G.L., D.J.R.), University of Pennsylvania Perelman School of Medicine, Philadelphia.; Department of Genetics (D.J.R.), University of Pennsylvania Perelman School of Medicine, Philadelphia. The FH Foundation, Pasadena, California3University of Pennsylvania, Philadelphia Institute for Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania Departments of Medicine and Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia (D.J.R.) Department of Medicine, Division of Translational Medicine and Human Genetics, University of Pennsylvania, Philadelphia, PA, USA; Institute for Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia, PA, USA; Department of Genetics, University of Pennsylvania, Philadelphia, PA, USA. Institute for Translational Medicine and Therapeutics and Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104–5158, USA. From the Regeneron Genetics Center (N.S.A.-H., A.H.L., C.S., S. McCarthy, C.O., J.S.P., S.B., N.G., S. Mukherjee, A.E.L., E.D.F., J.P., I.B.B., A.R.S., J.G.R., J.D.O., O.G., T.M.T., A.B., F.E.D.) and Regeneron Pharmaceuticals (X. Cheng, Y.X., P.S., Y.L., D.E., S.Y.K., B.Z., W.O., A.J.M., G.D.Y., J.G.), Tarrytown, NY; the University of Texas Southwestern Medical Center at Dallas, Dallas (J.K., S.S., H.H.H., J.C.C.); and Geisinger Health System, Danville (G.C.W., A.N.S., M.D.S., X. Chu, J.Z.L., U.L.M., D.J... Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104;; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104 Department of Genetics, University of Pennsylvania, Philadelphia From the Department of Medicine (K.M.P., A.S., J.T., J.B., J.M., D.J.R.) and Department of Genetics (D.J.R.), Perelman School of Medicine at the University of Pennsylvania, Philadelphia; Section of Experimental Atherosclerosis, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD (X.J., H.K.); and Department of Anatomy and Cell Biology, McGill University, Montreal, Quebec, Canada (C.R.M.). From the Department of Medicine (D.J.R.), University of Pennsylvania School of Medicine, and Wistar Institute (E.P.), Philadelphia, Pa, and Ludwig Institute for Cancer Research (E.P.), New York, NY. Sandia National Laboratories Engineering Sciences Center, , Albuquerque, New Mexico 87185-0826, USA From Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia (D.S., W.Z.); Center for Non-Communicable Diseases, Karachi, Pakistan (D.S., A.R., P.M.F., PROMIS); Department of Public Health and Primary Care, University of Cambridge, United Kingdom (R.Y., W.K.H., EPIC-CVD); Department of Cardiovascular Sciences, University of Leicester, United Kingdom (C.P.N., N.J.S.); Cardiology Division, Department of Medicine, Vanderbilt University, Nashville, TN (J.F.F., K.O.);... From the Lipid Research Group (E.T.A., G.L.W., M.R.J., C.V., G.H.R., M.C.P.), the Children’s Hospital of Philadelphia, and the Department of Medicine (D.J.R.), University of Pennsylvania School of Medicine, Philadelphia. Department of Genetics (D.J.R.) From the Institute for Translational Medicine and Therapeutics and the Cardiovascular Institute (H.T., J.T.B., J.-i.T., Y.Z.Z., D.J.R.), University of Pennsylvania School of Medicine, Philadelphia, and the Children’s Hospital of Philadelphia (G.R.), Pa. From the Division of Gasteroenterology and Nutrition (G.L.W., E.T.A., M.R.J., S.L-K., M.C.P., G.H.R.), The Children’s Hospital of Philadelphia, and the Department of Medicine (D.J.R.), University of Pennsylvania School of Medicine, Philadelphia, Pa. From the Hanson Institute and the Department of Cardiology (P.J.B.), Royal Adelaide Hospital, Adelaide, Australia; the National Heart, Lung, and Blood Institute (H.B.B. Jr), National Institutes of Health, Bethesda, Md; the National Institute for Health and Medical Research and Hopital de la Pitie (M.J.C.), Paris, France; the Preventive Cardiology and Lipid Clinic (D.J.R.), University of Pennsylvania Medical Center, Philadelphia; the Mount Sinai Medical Center–Miami Heart Institute and the... †Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104; and From the Department of Medicine (Cardiology), Icahn School of Medicine at Mount Sinai, New York, NY (R.S.R.); Cardiovascular Research Institute, Medstar Research Institute, Washington Hospital Center, DC (H.B.B.); and Departments of Medicine and Genetics and Cardiovascular Institute, Perelman School of Medicine of the University of Pennsylvania, Philadelphia (D.J.R.). From the Institute for Translational Medicine and Therapeutics (H.L., D.J.R.), and Lipid Research Group, The Children’s Hospital of Philadelphia (P.D., E.T.A., M.C.P., S.L-K.), University of Pennsylvania Perelman School of Medicine, Philadelphia, PA. From the Departments of Pathology and Laboratory Medicine (Divisions of Laboratory Medicine and Neuropathology) and Medicine, University of Pennsylvania Medical Center, Philadelphia, PA; the Department of Neurology, Pennsylvania Hospital and Thomas Jefferson University, Philadelphia, PA; the School of Life and Health Sciences, University of Delaware, Newark, DE; and the Division of Pulmonary and Critical Care, Department of Medicine, University of California at Los Angeles, Los Angeles, CA. Division of Translational Medicine and Human Genetics, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia (D.R., D.S.). University of Pennsylvania Philadelphia USA University of Pennsylvania and University of Pennsylvania Health System, Philadelphia, Pennsylvania (D.J.R.) From the Saha Cardiovascular Research Center, University of Kentucky, Lexington (A.D.); Department of Medicine, Columbia University Medical Center, New York, NY (I.T.); and Departments of Medicine and Genetics, Institute for Translational Medicine and Therapeutics, and Cardiovascular Institute, Perelman School of Medicine of the University of Pennsylvania, Philadelphia (D.J.R.). Author affiliations are provided at the end of the article. From the Institute for Translational Medicine and Therapeutics and Department of Medicine (K.A., D.J.R.) and Immunology Graduate Group (M.M.), University of Pennsylvania School of Medicine, Philadelphia; Wistar Institute (M.M., E.P.), Philadelphia; and The Ludwig Institute for Cancer Research, Philadelphia, Penn. From the Institute for Translational Medicine and Therapeutics (J.S.M., A.F., M.L.W., D.J.R.), University of Pennsylvania School of Medicine, Philadelphia; Lipid Metabolism Laboratory (M.E.B., M.R.D., F.K.W., C.N., E.J.S.), JM-USDA-HNRCA at Tufts University, and Tufts-New England Medical Center, Boston, Mass; Schools of Medicine and Pharmacology (P.H.R.B.), University of Western Australia, Perth, Australia; Division of Cardiology (F.K.W.), Beth Israel Deaconess Medical Center, Boston, Mass; Clinical... From Center for Human Genetic Research and Cardiovascular Research Center, Massachusetts General Hospital, Boston (P.N., S.K.); Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge (P.N., S.K.); Department of Medicine, Harvard Medical School, Boston, MA (P.N., S.K.); Department of Public Health and Primary Care, Strangeways Research Laboratory, University of Cambridge, United Kingdom (R.Y., A.B.); Division of Statistical Genetics... Departments of Genetics and Medicine, Division of Translational Medicine and Human Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA From GlaxoSmithKline (A.M.V., E.J.O., N.K.S., A.R., P.H.E.G.), Stevenage, Hertfordshire, UK, and the University of Pennsylvania School of Medicine (M.L.W., W.G., D.J.R.), Philadelphia. Division of Translational Medicine and Therapeutics, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. Institute for Translational Medicine and Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Institute for Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. From the Columbia University, New York, NY (G.R.-S., C.N., E.C., D.S.D., W.K., R.R., S.H., T.T., H.N.G.); University of Pennsylvania, Philadelphia (J.S.M., R.L.D., E.M.d., A.L.B., D.J.R.); Merck & Co., Inc., Kenilworth, NJ (P.J., A.O.J.-L., J.A.W., Y.L., M.E.L., D.E.G.); Tufts University School of Medicine, Boston, MA (B.A.); and Drexel Neurological Associates, Philadelphia, PA (H.R.) Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104. From the Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia (D.J.R); and Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands (J.J.P.K.) Department of Medicine, Division of Translational Medicine and Human Genetics Perelman School of Medicine at the University of Pennsylvania Philadelphia Pennsylvania USA; Department of Medicine, Division of Cardiovascular Medicine Perelman School of Medicine at the University of Pennsylvania Philadelphia Pennsylvania USA; Institute for Translational Medicine and Therapeutics Perelman School of Medicine at the University of Pennsylvania Philadelphia Pennsylvania USA; The Cardiovascular Institute Perelman School of Medicine at the University of Pennsylvania Philadelphia Pennsylvania USA Department of Medicine and Center for Experimental TherapeuticsUniversity of Pennsylvania School of MedicinePhiladelphiaPennsylvania Department of Medicine (Cardiovascular), School of Medicine, University of Pennsylvania, Philadelphia, PA 19104. Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA Institute for Translational Medicine and Therapeutics, Cardiovascular Institute, and Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA. From the Department of Medicine, University of Pennsylvania, Philadelphia, Pa. Department of Medicine and Cardiovascular Institute, and; Institute for Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA From the Division of Cardiology, Department of Medicine (A.J.) and Institute for Translational Medicine and Therapeutics, Cardiovascular Institute, and Department of Medicine (D.J.R.), University of Pennsylvania, Philadelphia. From the Institute for Translational Medicine and Therapeutics (T.N., M.A.P., M.A., I.M.S., J.T.B., D.J.R.) and Cardiovascular Institute (D.J.R.), University of Pennsylvania School of Medicine, Philadelphia; and the Children’s Hospital of Philadelphia (G.R), Pa. Department of Genetics, Institute for Translational Medicine and Therapeutics, Perelman School of Medicine at University of Pennsylvania, Philadelphia Departments of Genetics and Medicine, Perelman School of Medicine, University of Pennsylvania , Philadelphia , USA Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Genetics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA Departments of Genetics, Medicine, and Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia (D.J.R.). From the Center for Experimental Therapeutics (T.C., D.P., L.Z., G.A.F., C.D.F.) and the Department of Medicine (D.J.R.), University of Pennsylvania, Philadelphia; the Department of Medicine, University of California–San Diego (J.L.W.); and the Claude Pepper Institute and Department of Chemistry, Florida Institute of Technology, Melbourne (J.R.). From the Departments of Pediatrics (D.S., C.M., A.K.G., L.L.G., K.L.C., L.D.H., M.L.C., P.W.S.) and Internal Medicine (W.V., R.L.K.) and the Donald W. Reynolds Cardiovascular Clinical Research Center (W.V.), University of Texas Southwestern Medical Center, Dallas, Tex; Lipoprotein and Atherosclerosis Research Group (Y.L.M.), University of Ottawa Heart Institute, Ottawa, Canada; and the Department of Medicine (D.J.R.), University of Pennsylvania School of Medicine, Philadelphia, Pa. From the Donald W. Reynolds Cardiovascular Clinical Research Center (W.A., G.O., V.N., O.Z., J.P.), Cardiovascular Division, Brigham and Women’s Hospital, Harvard Medical School, Boston, Mass; the Department of Medicine (D.J.R.), University of Pennsylvania, Philadelphia; and the School of Pharmacy (L.A.), University of Southern California, Los Angeles. From the Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, Md (H.S., E.A.S., L.M.Y.-A., J.L., J.R.O., A.R.S., B.D.M.); Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, Mich (L.F.B., S.L.R.K., Y.V.S., M.A.J., P.A.P.); The Cardiovascular Institute (J.F.F., N.N.M., B.J.K., D.J.R., M.P.R.), Biostatistics and Epidemiology (X.W., M.L.), and The Institute for Translational Medicine and Therapeutics, School of... From the Institute for Translational Medicine and Therapeutics and Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia. Cardiovascular Institute; Institute for Diabetes, Obesity and Metabolism; and Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104; The Cardiovascular Institute, and the Institute for Translational Medicine and Therapeutics, School of Medicine, University of Pennsylvania, Philadelphia From the Stokes Research Institute and Departments of Pediatrics and Pharmacology (I.P., L.T., D.M.F., H.I.), Children’s Hospital of Philadelphia and The University of Pennsylvania, Philadelphia; the Department of Medicine (R.E.M., J.T., D.J.R.), The University of Pennsylvania, Philadelphia; the Department of Cardiovascular Medicine and Center for Cardiovascular Diagnostics and Prevention (X.F., S.L.H.), Cleveland Clinic Foundation, Cleveland Ohio; the Laboratory of Clinical Chemistry and Hematology... Cardiovascular Division, Brigham and Women's Hospital, Harvard University, Boston, MA 02115; School of Pharmacy, University of Southern California, Los Angeles, CA 90089; Merck Research Laboratories, Rahway, NJ 07065; Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104; and University of Graz, A-8010 Graz, Austria Departments of Medicine and Genetics, University of Pennsylvania, Philadelphia3Institute for Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia From the Cardiovascular Research Methods Center (R.W.D., G.A.W., L.C.), John and Jennifer Ruddy Canadian Cardiovascular Research Center, University of Ottawa Heart Institute, Ottawa, Canada (A.F.R.S., S.D., R.R., R.M.); Medizinische Klinik II, Lübeck, Germany (J.E., J.N., C.L., H.S.); the Department of Medicine, Duke University Medical Center, Durham, NC (S.H.S., W.E.K., C.B.G.); the Cardiovascular Institute, University of Pennsylvania, Philadelphia, PA (J.F.F., M.P.R.); the Division of... From the Cardiovascular Division, Department of Medicine, the Center for Experimental Therapeutics and the Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, Penn. From the School of Nursing (K.O.B.), Institute of Translational Medicine and Therapeutics (K.O.B., M.L.W., M.P.R., D.J.R.), School of Medicine (M.P.R., D.J.R.), and Cardiovascular Institute (M.P.R.), University of Pennsylvania, Philadelphia. Department of Genetics, Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania USA From the Laboratory of Lipids and Lipoproteins, Department of Clinical Biochemistry, Faculty of Pharmacy and Biochemistry, Institute of Physiopathology and Clinical Biochemistry, University of Buenos Aires, Argentina (V.M., L.S., D.L., G.B.); Institute for Translational Medicine and Therapeutics, School of Medicine, University of Pennsylvania, PA (M.M., J.B., D.J.R.); and Department of Gastroenterology, National Hospital Prof. A. Posadas, Buenos Aires, Argentina (E.F.). Department of Genetics University of Pennsylvania Philadelphia Pennsylvania USA; Division of Translational Medicine and Human Genetics Department of Medicine University of Pennsylvania Philadelphia Pennsylvania USA; Cardiovascular Institute University of Pennsylvania Philadelphia Pennsylvania USA Department of Medicine, Translational-Clinical Research, University of Pennsylvania , Philadelphia, PA, USA Department of Genetics Perelman School of Medicine, University of Pennsylvania Philadelphia PA USA From the Department of Medicine, Divisions of Cardiology (A.J.) and Translational Medicine and Human Genetics (D.J.R.), University of Pennsylvania, Philadelphia; and Emeritus Professor of Medicine, University of Cincinnati, OH (S.J.). From the Department of Bioscience, CVMD iMED, AstraZeneca, R&D, Mölndal, Sweden (E.H.-C., B.R., M.B.); Department of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands (T.G., A.D., U.J.F.T.); INSERM UMR866, Faculté de Médecine, Université de Bourgogne, Dijon, France (T.G.); Taconic, Hudson, NY (D.S.G.); and Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine, Philadelphia (D.J.R.). From the Department of Medicine (J.S.M., C.M., D.M.K., E.C.B., J.M.W., D.J.R.), University of Pennsylvania, Philadelphia; the Division of Cardiology (K.I., S.M.), Department of Internal Medicine and the Department of General Medicine (N.T.), Kashiwa Hospital, Jikei University School of Medicine, Tokyo, Japan; the School of Medicine and Pharmacology (P.H.R.B.), University of Western Australia, Perth; the Biomathematics Unit (R.C.B.), University of Pennsylvania School of Veterinary Medicine, Kennett... Corporal Michael Crescenz VA Medical Center, Philadelphia, PA (R.L.K., M.L., D.S., K.-M.C., D.J.R., S.M.D.). Department of Medicine (J.A.E., D.J.R., M.S.P.), University of Pennsylvania, Philadelphia, Pennsylvania 19104; Center for Experimental Therapeutics (D.J.R.), University of Pennsylvania, Philadelphia, Pennsylvania 19104 Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania Department of Genetics, Cardiovascular Institute and Institute of Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania. Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA;; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA; Division of Translational Medicine and Human Genetics, Perelman School of Medicine University of Pennsylvania Philadelphia PA USA Medicine (J.A.G., D.J.R., S.K.), Philadelphia, Pennsylvania 19104 Department of Medicine Perelman School of Medicine at the University of Pennsylvania Philadelphia PA; Department of Genetics Perelman School of Medicine at the University of Pennsylvania Philadelphia PA From the University of Pennsylvania, Philadelphia, Pa. Departments of Genetics, Medicine, and Pediatrics, and the Institute for Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia. Cardiovascular Institute and Institute for Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104. Perelman School of Medicine, University of Pennsylvania, Philadelphia (S.M.D., M.G.L., D.B., R.J., R.L.K., L.L., C.M.-R., A. Babu, M.M., A.S., H.W., K.B.M., T.P.C., A.V., X.Z., M.D.R., D.J.R., Z.A.). Department of Genetics (S.A.K., P.L.B., W.Z., W.F.H.-C., C.D.B., D.J.R.); Institute for Translational Medicine and Therapeutics (D.J.R., B.F.V.) Cardiovascular Institute, Division of Cardiovascular Medicine, Department of Medicine, and Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; Institute of Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania. Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia; Department of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia; Institute for Translational Medicine and Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia From the Broad Institute (K.M., G.L., T.Y., D.N.F., J.P.P., K.G.E., N.L., A.C., L.Z., A.R., J.N.H., C.H.N.-C., S.K., S.B.G.), Cambridge, Mass; Massachusetts General Hospital (K.M., J.P.P., K.G.E., C.H.N.-C., S.K.), Boston, Mass; Harvard Medical School (K.M., C.H.N.-C., J.N.H., S.K.), Boston, Mass; Johns Hopkins University School of Medicine (K.M., J.P.P.), Baltimore, Md; Montreal Heart Institute (G.L.), Université de Montréal, Montreal, Canada; Boston University (Q.Y., M.-H.C., E.J.B., L.A.C., R.S.V... Perelman School of Medicine, University of Pennsylvania, Philadelphia Department of Medicine and Genetics, Perelman School of Medicine of the University of Pennsylvania, Philadelphia, Pennysylvania From the Wistar Institute and The Ludwig Institute for Cancer Research, Philadelphia, Pa; and the Department of Medicine and the Graduate Group in Immunology, University of Pennsylvania School of Medicine, Philadelphia. From the Cardiovascular Institute (X.W., E.E.P., D.J.R., K.M.), Department of Medicine (X.W., E.E.P., D.J.R., K.M.), and Department of Genetics (X.W., E.E.P., D.J.R., K.M.), Perelman School of Medicine, University of Pennsylvania, Philadelphia; and Harvard Medical School, Boston, MA (A.R., D.T.P.). Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Division of Translational Medicine and Human Genetics, University of Pennsylvania, Philadelphia, Pennsylvania; Division of Translational Medicine and Human Genetics, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania 19104 From the Division of Translational Medicine and Human Genetics, Department of Medicine (S.T.N., R.C.B., D.J.R.), Penn Cardiovascular Institute, Department of Medicine (H.Z., M.P.R., D.J.R.), Department of Genetics (N.J.H., D.J.R.), and Department of Biostatistics and Epidemiology (D.S.), Perelman School of Medicine, University of Pennsylvania, Philadelphia. From the Department of Medicine, Robarts Research Institute, Schulich School of Medicine, Western University, London, Ontario, Canada (R.A.H.); Nemours Cardiac Center, A. I. duPont Hospital for Children, Wilmington, DE (S.S.G.); Irving Institute for Clinical and Translational Research, Department of Medicine, Columbia University, New York, NY (H.N.G.); Department of Medicine and Biochemistry, Atherogenomics Laboratory, University of Ottawa Heart Institute, Ottawa, Ontario, Canada (R.M.);... From the Gene Therapy Program, Department of Pathology and Laboratory Medicine (S.S., F.J., Q.W., J.M.W.), Department of Nursing Research, School of Nursing (A.L.H.), and Departments of Medicine and Genetics and Cardiovascular Institute (D.J.R.), Perelman School of Medicine, University of Pennsylvania, Philadelphia; and Discovery Sciences, Janssen, Pharmaceutical companies of Johnson and Johnson, Beerse, Belgium (F.J.). Medicine (K.H., D.J.R., R.E.P.); Genetics (R.L.K., D.J.R.) Department of Genetics, University of Pennsylvania, Philadelphia, Pennsylvania. Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Institute for Translational Medicine and Therapeutics,University of Pennsylvania,Philadelphia,PA Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia From Division of Gastroenterology, Hepatology and Nutrition (M.L.L.M., D.D.S., G.H.R.), The Children’s Hospital of Philadelphia, Philadelphia, Pa; Lipid Metabolism Laboratory (B.F.A.), Tufts University, Boston, Mass; Institute of Translational Medicine and Therapeutics (M.C., D.J.R.), The University of Pennsylvania School of Medicine, Philadelphia, Pa. Department of Medicine, Division of Cardiology, Hospital of the University of Pennsylvania, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA From the Cardiovascular and Pulmonary Branch (A.A.J., J.B.L., T.M.A., H.L.T., J.A.R., Q.N., T.Z.A., T.S., B.N., M.Y.C., A.T.R., D.A.B., M.P.P., N.N.M.), Section of Inflammation and Cardiometabolic Diseases (A.A.J., J.B.L., T.M.A., H.L.T., J.A.R., Q.N., T.Z.A., T.S., B.N., A.T.R., M.P.P., N.N.M.), National Heart, Lung, and Blood Institute, Bethesda, MD; Department of Internal Medicine, Allegheny General Hospital, Pittsburgh, PA (A.A.J.); Department of Medicine, McGill University, Montreal, QC, Canada... Departments of Genetics and Medicine, Institute for Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA From the Cardiovascular Institute, Institute for Diabetes Obesity and Metabolism, and Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine, Philadelphia. From the Institute for Translational Medicine and Therapeutics, School of Medicine, University of Pennsylvania, Philadelphia. From the Departments of Medicine and Physiology (G.F.L), University of Toronto, Canada; The Institute for Translational Medicine and Therapeutics (D.J.R.), The Cardiovascular Institute, and the Institute for Diabetes, Obesity, and Metabolism, University of Pennsylvania School of Medicine, Philadelphia. The Institute for Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia Penn Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104; From the Departments of Medicine (Y.Z., M.R., D.J.R.) and Cell and Developmental Biology (J.M.G.) and the Center for Experimental Therapeutics (Y.Z., M.R., D.J.R.), University of Pennsylvania School of Medicine, Philadelphia, Pa; and the Children’s Hospital of Philadelphia (I.Z., G.H.R.), Philadelphia, Pa. University of Pennsylvania School of Medicine, Philadelphia, USA. Division of Translational Medicine and Human Genetics, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia (S.T, D.J.R); Department of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia (D.J.R.) Cardiovascular Institute, Perelman School of Medicine at the University of Pennsylvania, 3400 Civic Center Blvd, Building 421, Translational Research Center, Philadelphia, PA 19104-5158, USA. Division of Translational Medicine and Human Genetics, Perelman School of Medicine at the University of Pennsylvania, 3400 Civic Center Blvd, Building 421, Translational Research Center, Philadelphia, PA 19104-5158, USA. Division of Translational Medicine and Human Genetics, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.; Department of Genetics, University of Pennsylvania, Philadelphia, Pennsylvania. Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. From the Division of Translational Medicine and Human Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia. From the Department of Medicine, Brigham and Women’s Hospital, Boston, MA (AVK); and Division of Translational Medicine and Human Genetics, Department of Medicine and Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA (DJR). Department of Genetics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA. Cardiovascular Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA. From the Preventive Cardiology Section (P.D.T.), Division of Cardiology, Hartford Hospital, Hartford, Conn, and the Divisions of Experimental Therapeutics and Cardiology (D.J.R.), University of Pennsylvania, Philadelphia, Pa. From the University of Pennsylvania School of Medicine, Philadelphia, Pa. From Mount Sinai Heart (R.S.R., V.F.) and the Translational and Molecular Imaging Institute (Z.A.F.), Mount Sinai School of Medicine, New York, NY; Cardiovascular Research Institute, MedStar Research Institute, Washington Hospital Center, Washington, DC (H.B.B.); Center for Lipid and Arteriosclerosis Science, University of Cincinnati, Cincinnati, OH (W.S.D.); Oakland University William Beaumont School of Medicine, William Beaumont Hospital, Royal Oak, MI (J.G.); University of California Berkeley,... Department of Pediatrics, Division of Human Genetics, Section of Biochemical Genetics, Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA From the Department of Pathology and Laboratory Medicine, The Children’s Hospital of Philadelphia, Philadelphia, PA (S.-Y.J., N.N.C., X.L.Z.); Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA (J.T., R.C.B., D.J.R.); and Department of Pathology and Laboratory Medicine, and Medicine, The University of Pennsylvania Perelman School of Medicine, Philadelphia, PA (D.J.R., X.L.Z.). From the Department of Molecular and Cellular Engineering (K.F.K., M.H.D., J.M.G.), Department of Medicine (D.J.R.), and Institute for Human Gene Therapy (K.F.K., M.H.D., J.M.G., D.J.R.), University of Pennsylvania Health System, Philadelphia, Pa, and the Department of Biology, Massachusetts Institute of Technology, Cambridge (M.K.). K.F. Kozarsky and M.H. Donahee are now at the Department of Cardiovascular Pharmacology, SmithKline Beecham Pharmaceuticals, King of Prussia, Pa. From the Department of Medicine, University of Pennsylvania School of Medicine (R.K.T., K.T., D.J.R.), and the Wistar Institute (S.H.C., E.P.), Philadelphia, Pa, and the University of Delaware, Newark (D.U.). From the Institute for Translational Medicine and Therapeutics (A.C.E., I.M.S., A.V.K., M.L.W., S.L.D., B.J.K., M.P.R., D.J.R.), Department of Biostatistics and Epidemiology (L.Q., J.H., M.L.), and Cardiovascular Institute (M.P.R., D.J.R.), University of Pennsylvania School of Medicine, Philadelphia, PA; Department of Cardiovascular Sciences (P.S.B., C.P.N., M.T., N.J.S.) and Department of Health Sciences (M.D.T.), University of Leicester, Leicester, UK; Leicester NIHR Biomedical Research Unit in... Department of Medicine and Center for Experimental Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-6160 From the Cardiovascular Institute (H.Z., C.X., R.S., K.B., C.C.H., W.L., A.R., J.T.-M., E.E.P., E.E.M., D.J.R., M.P.R.), and Department of Biostatistics and Epidemiology (M.L.), Perelman School of Medicine, Institute for Translational Medicine and Therapeutics, Institute for Diabetes, Obesity, and Metabolism (A.R., M.C., E.E.P., D.J.R.), Department of Medicine, Metabolic Tracer Resource, Institute for Diabetes, Obesity, and Metabolism (J.S.M.), Institute for Regenerative Medicine (Y.L., R.Y., W.Y.,... From the Cardiovascular Institute and Institute of Translational Medicine and Therapeutics, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA; Institute for Translational Medicine & Therapeutics1University of Pennsylvania School of Medicine, Room 654, Biomedical Research Building II/III, PA 19104-16160, 421 Curie Boulevard, USA Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States; Department of Medicine, University of Pennsylvania, Philadelphia, United States Department of Medicine,Division of Translational Medicine and Human Genetics,Perelman School of Medicine,University of Pennsylvania,Philadelphia,PA From the Nutrigenomics Research Group, UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin, Ireland (F.C.M.); and the Institute for Translational Medicine and Therapeutics, Cardiovascular Institute, and Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA (M.P.R., D.J.R.). From the Department of Cardiovascular Sciences and NIHR Leicester Biomedical Centre, University of Leicester, United Kingdom (A.L.K., V.C., N.G.D.M., C.P.N., M.D.M., N.J.S.); German Heart Center, Technische Universität, Munich, Germany (B.M.K., C.H.); Department for Internal Medicine I, St. Josefs-Hospital, Wiesbaden, Germany (B.M.K.); German Center for Cardiovascular Research, Partner Site Munich Heart Alliance, Munich, Germany (C.H.); and Department of Genetics, Perelman School of Medicine,... Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. rader@pennmedicine.upenn.edu. Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. rader@pennmedicine.upenn.edu. Institute for Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. rader@pennmedicine.upenn.edu. From the Division of Cardiology (J.A., L.G., H.W., E.A.F.), Department of Medicine (J.A., L.G., H.W., E.A.F.), and Marc and Ruti Bell Program in Vascular Biology (J.A., E.A.F., L.G, H.W.), NYU School of Medicine; Institute for Translational Medicine and Therapeutics, Cardiovascular Institute, and Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia (A.S., D.J.R.); Department of Developmental and Molecular Biology, Albert Einstein... From University of Cape Town, South Africa (D.J.B.); Università di Palermo, Italy (M.R.A.); University of Pennsylvania, Philadelphia (E.A.M., D.J.R. M.C.); Netcare Private Hospital, Bloemfontein, South Africa (H.d.T.T.); Ospedale Niguarda, Milano, Italy (R.A.H.); University of Western Ontario, London, Canada (R.A.H.); Cedars-Sinai Heart Institute, Los Angeles, CA (P.K.S.); Université de Montreal, Chicoutimi, Quebec, Canada (D.G.); Università di Roma Sapienza, Italy (C.S.); Università di Ferrara,... From the Department of Stem Cell and Regenerative Biology, Harvard University and Harvard Stem Cell Institute, Cambridge, MA (Q.D., S.-L.N., B.S.G., S.N.R., C.A.C., K.M.); Institute for Translational Medicine and Therapeutics, Institute for Diabetes, Obesity and Metabolism, and Cardiovascular Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia (A.S., K.M.P., D.J.R.); Division of Cardiovascular Medicine, Brigham and Women’s Hospital, Boston, MA (K.M.); and Broad... Division of Human Genetics,Children's Hospital of Philadelphia,Philadelphia,PA; Department of Genetics,Perelman School of Medicine,University of Pennsylvania,Philadelphia,PA; Department of Medicine,Perelman School of Medicine,University of Pennsylvania,Philadelphia,PA; Institute for Translational Medicine and Therapeutics,Perelman School of Medicine,University of Pennsylvania,Philadelphia,PA Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia Dr. Hunter is a professor in the Departments of Epidemiology and Nutrition at the Harvard School of Public Health, Boston, and a statistical consultant for the Journal. Dr. Altshuler is a professor in the Departments of Genetics and Medicine, Harvard Medical School and Massachusetts General Hospital, Boston. Dr. Rader is a professor of medicine and pharmacology and associate director of the Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine, Philadelphia. Exploratory and Translational Sciences, Merck Research Laboratories, Rahway, NJ From the Institute for Translational Medicine and Therapeutics and the Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, Pa. Department of Medicine, University of Adelaide, North Terrace, and Lipid Research Laboratory, Hanson Institute, Adelaide, South Australia, Australia 5000, and Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 From the University of Pennsylvania, Philadelphia (E.M.d., D.J.R.); University of Texas Southwestern, Dallas (Z.S.A.); Duke Clinical Research Institute, Durham, NC (E.C.O., P.S., M.T.R.); The FH Foundation, South Pasadena, CA (I.K., C.D.A., K.W.); New York University School of Medicine (C.B.N.); Mid America Heart Institute, Kansas City, MO (Y.P.); Preventive Cardiology Inc, Boca Raton, FL (S.J.B.); Massachusetts General Hospital, Boston (L.C. Hemphill); The Rogosin Institute, New York, NY (L.C.... Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA From the Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas (S.M.G.); Framingham Heart Study, Boston University, Boston, Mass (R.B.D., P.W.F.W.); Preventive Cardiology, Columbia and Cornell Universities, New York, NY (L.M.); Wake Forest School of Medicine, Winston-Salem, NC (G.B.); Preventive Cardiology and Lipid Research Center, University of Pennsylvania Health System, Philadelphia (D.R.); and Office of Prevention, Education, and Control (J.I.C., E.R.), Division of... From the Institute for Translational Medicine and Therapeutics (S.Y., H.T., X.L., Y.K., J.T.B., D.J.R.), Cardiovascular Institute (J.T.B., D.J.R.), and Department of Medicine (D.J.R.), Perelman School of Medicine, University of Pennsylvania, Philadelphia. Department of Medicine (D.J.R.), Perelman School of Medicine, University of Pennsylvania, Philadelphia; Department of Genetics (D.J.R.), Perelman School of Medicine, University of Pennsylvania, Philadelphia deCODE genetics, Sturlugata 8, IS-101 Reykjavik, Iceland.; Landspitali University Hospital, Reykjavik, Iceland.; Emory University School of Medicine, Atlanta, GA 30322, USA.; University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.; Duke University School of Medicine, Durham, NC 27710, USA. Perlman School of Medicine, University of Pennsylvania, Philadelphia, PA (D.J.R.) Division of Translational Medicine and Human Genetics, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA; Department of Genetics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA From the Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine, Philadelphia. Division of Translational Medicine and Human Genetics, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania From the Lipid Metabolism Laboratory (M.E.B., M.R.D., C.N., B.F.A., E.J.S.), JM-USDA-HNRCA at Tufts University and Tufts-New England Medical Center, Boston, Mass; Department of Medicine and Center for Experimental Therapeutics (J.S.M., M.L.W., D.J.R.), University of Pennsylvania School of Medicine, Philadelphia; Division of Cardiology (F.K.W.), Beth Israel Deaconess Medical Center, Boston, Mass; Department of Medicine (M.R., I.B., B.A.), Center for Metabolism and Endocrinology and Center for... From the Department of Medicine and Institute for Translational Medicine and Therapeutics (R.J.B., W.R.L., T.Y., D.J.R.), University of Pennsylvania School of Medicine, Philadelphia; Division of Gastroenterology and Nutrition (S.S., G.H.R.), The Children's Hospital of Philadelphia, Pa; and the Donald W. Reynolds Cardiovascular Clinical Research Center and Divisions of Cardiovascular Medicine and Gastroenterology (T.Q.), Stanford University School of Medicine, Stanford, Calif. From the Departments of Pharmacology (J.S.M.) and Medicine (D.D., R.G., L.T.B., R.L.D., M.L.W., A.S., I.V.F., M.M., D.J.R.), Institute for Translational Research and Therapeutics, University of Pennsylvania, Philadelphia; Pennsylvania Hospital (R.M.), Philadelphia; and Eli Lilly and Company (C.J.H., M.-D.W., D.C.H.), Indianapolis, Ind. From the Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia (Dr Doshi, J.T. Puckett, Dr Parmacek, and Dr Rader) and the Leonard Davis Institute of Health Economics, Philadelphia (Dr Doshi). Department of Genetics, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. Departments of Genetics, Medicine, and Surgery, Perelman School of Medicine, University of Pennsylvania, and Corporal Michael J. Crescenz Veterans Affairs Medical Center, Philadelphia, PA 19104, USA. University of Pennsylvania School of Medicine, Philadelphia. From the Division of Cardiology, Department of Medicine, Hospital of the University of Pennsylvania (A.S., D.K., J.G., S.A., H.S., M.G., J.A.C., D.J.R.), Division of Cardiovascular Surgery, Department of Surgery (G.F.), and Department of Genetics (D.J.R.), Perelman School of Medicine, University of Pennsylvania, Philadelphia. From the Regeneron Genetics Center (N.V., M.E.H., J.B.N., O.A.S., M.K., P.A., T.D., G.H., J.B., T.P., L.M., K.W., J. Mbatchou, M.J., M.L., S.B., J.D.O., J.G.R., A.E., M.N.C., G.R.A., M.A.R.F., J. Marchini, H.M.K., K.K., A.R.S., G.D.G., A.E.L., A.B., L.A.L.), Regeneron Pharmaceuticals (M.G., L.P., P.P., J.R.W., B.Z., A.J.M., E.S., V.G., M.S., G.D.Y.), Tarrytown, NY; Indiana University School of Medicine, Indianapolis (C.L.); the Department of Clinical Sciences Malmö, Lund University, and the Department of... From the Department of Medicine (K.T., R.T., D.J.R.), University of Pennsylvania School of Medicine, and the Wistar Institute (S.H.C., E.P.), Philadelphia, Pa. From the University of Pennsylvania School of Medicine, Department of Medicine and Center for Experimental Therapeutics. Philadelphia, Pa. The Institute for Translational Medicine and Therapeutics, University of Pennsylvania, PA 19104, USA.; Department of Medicine, University of North Carolina, NC 27599, USA. Department of Medicine, Division of Translational Medicine and Human Genetics (S.T., K. Monono, D.J.R.), University of Pennsylvania Perelman School of Medicine, Philadelphia.; Department of Genetics (D.J.R.), University of Pennsylvania Perelman School of Medicine, Philadelphia. Department of Genetics Perelman School of Medicine at the University of Pennsylvania Philadelphia Pennsylvania United States Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia; Division of Translational Medicine and Human Genetics, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Pennsylvania Institute for Translational Medicine and Therapeutics and Cardiovascular Institute; University of Pennsylvania School of Medicine, Philadelphia, PA From the Division of General Internal Medicine (P.O.S., L.T.B.), Institute for Translational Medicine and Therapeutics (P.O.S., L.T.B., M.L.W., D.J.R.), Division of Cardiovascular Medicine (F.S., M.P.R.), and Center for Clinical Epidemiology and Biostatistics (P.O.S., J.C., M.P.R.), University of Pennsylvania School of Medicine, Philadelphia, Pa. Current affiliation for P.O.S. is Wyeth Research, Collegeville, Pa. Division of Translational Medicine and Human Genetics, Cardiovascular Institute and Institute for Translational Medicine and Therapeutics, and Department of Genetics (R.L.K., D.J.R.), Perelman School of Medicine, University of Pennsylvania, Philadelphia. From the Institute for Translational Medicine and Therapeutics, University of Pennsylvania (M.W., W.S., E.R., D.J.R., J.A.L., G.A.F.); and the Wistar Institute (E.L., E.P.), Philadelphia, Pa. Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. From the The Wistar Institute (L.Z., E.L., A.M.Z., M.K.M., M.K., P.S.A., J.A.H., E.P.), Philadelphia, Pa; the Department of Medicine (P.S.A., D.J.R., E.P.) and the Immunology Graduate Group (M.K.M., M.K., E.P.), University of Pennsylvania School of Medicine, Philadelphia; and the Ludwig Institute for Cancer Research (E.P.), Philadelphia, Pa. Department of Genetics, Perelman School of Medicine,University of Pennsylvania,Philadelphia,PA; Department of Translational Medicine and Human Genetics,Perelman School of Medicine,University of Pennsylvania,Philadelphia,PA; Department of Medicine,Perelman School of Medicine,University of Pennsylvania,Philadelphia,PA; Division of Cardiology and Cardiovascular Institute, Department of Medicine, Perelman School of Medicine,University of Pennsylvania,Philadelphia,PA 1 Department of Biostatistics and Epidemiology, 2 Cardiovascular Institute, 3 Department of Pathology and Laboratory Medicine, 4 Penn Center for Bioinformatics and 5 Institute on Aging, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA From the Department of Medicine, University of Pennsylvania, Philadelphia. From the Lipid Research Group, Children's Hospital of Philadelphia, Philadelphia, Pa (E.T.A., C.V., S.S., M.d.l.L.-M., G.H.R., M.C.P.); Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pa (D.J.R.). From the Department of Medicine and Cardiovascular Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia. Department of Medicine Division of Translational Medicine and Human Genetics, University of Pennsylvania Philadelphia PA 19104 USA Division of Translational Medicine and Human Genetics, The Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania USA; Department of Genetics, The Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania USA Institute for Translational Medicine and Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.; Departments of Genetics and Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. From the Columbia University, New York (T.T., W.K., R.R., S.H., H.N.G., G.R.-S.); Merck & Co, Inc, Kenilworth, NJ (H.Z., Y.L., P.J., J.A.W., B.H., S.F.P., T.R., A.O.J.-L., D.E.G.); University of Washington, Seattle (S.M.M.); and University of Pennsylvania, Philadelphia (D.J.R., J.S.M.). A list of the institutions and affiliations for the authors of this report may be found in the Appendix at the end of this article. From the Division of Molecular Medicine, Department of Medicine, Columbia University, New York (A.R.T.); and Departments of Genetics and Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia (D.J.R.) Department of Medicine, Division of Translational Medicine and Human Genetics, Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania USA From Institute for Translational Medicine and Therapeutics and Cardiovascular Institute (T.Y., J.T.B., F.B., D.J.R.), University of Pennsylvania School of Medicine, Philadelphia, Pa; GlaxoSmithKline Research Center (D.G., P.D., S.H.), Les Ulis, France. From the Departments of Genetics (R.L.K., D.L.C., S.F.A.G., D.J.R., B.F.V.), University of Pennsylvania; Medicine (M.G.L., D.J.R.), University of Pennsylvania From the Institute for Translational Medicine and Therapeutics (R.E.M., J.S.M., D.J.R.), University of Pennsylvania School of Medicine, Philadelphia; Department of Medicine (M.N., S.H.), David Geffen School of Medicine at UCLA, Los Angeles, Calif; and Division of Gastroenterology and Nutrition (F.Z., G.H.R.), Department of Pediatrics, Children’s Hospital of Philadelphia, Philadelphia, Pa. From the Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania. Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Institute for Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Electronic address: rader@pennmedicine.upenn.edu. Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA The Familial Hypercholesterolemia Foundation, Pasadena, California; Departments of Genetics, Medicine, and Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania. Department of Medicine, Perelman School of Medicine of the University of Pennsylvania, Philadelphia, PA, USA. Perelman School of Medicine, University of Pennsylvania, Philadelphia (J.B., D.J.R.). Department of Genetics Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania USA Departments of Medicine and Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA Division of Translational Medicine and Human Genetics, University of Pennsylvania, Philadelphia, PA From the Genetics Division, GlaxoSmithKline R&D, King of Prussia, Pa (D.M.W., K.S., X.Y., N.L., L. Cardon, V.M.); Department of Public Health and Primary Care, Strangeways Research Laboratory (S.L.R., S.A., E.H.Y., R.L., K.-T.K., M.S.S.) and Department of Public Health and Primary Care (S.A.R.), University of Cambridge, Cambridge, United Kingdom; Division of Cardiology, University of Ottawa Heart Institute, Ottawa, Ontario, Canada (L. Chen, R.R., A. Stewart, R.M.); Medical Research Council... From the Divisions of Cardiology (M.P.R., D.J.R.) and Endocrinology, Diabetes, and Metabolism (M.L., M.A.L.), Department of Medicine (M.P.R., M.L., M.L.W., A.R., M.A.L., D.J.R.), Center for Experimental Therapeutics, and the Penn Diabetes Center (M.P.R., M.L.W., D.J.R.), University of Pennsylvania School of Medicine, Philadelphia, Pa. Division of Translational Medicine and Human Genetics, Departments of Genetics and Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA From the Institute for Translational Medicine and Therapeutics (S.U.N., X.W., M.P.R., J.T.B., D.J.R.), Cardiovascular Institute (M.P.R., D.J.R.), and Institute for Diabetes Obesity and Metabolism (M.P.R., D.J.R.), University of Pennsylvania School of Medicine, Philadelphia; The Children’s Hospital of Philadelphia, Philadelphia, Pa (J.S.D., G.H.R.); and GlaxoSmithKline, King of Prussia, Pa (M.J., C.H.M.). University of Pennsylvania School of Medicine, Department of Medicine, Philadelphia, USA Institute for Translational Medicine and Therapeutics, and Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, PA Perelman School of Medicine. University of Pennsylvania School of Medicine/Hospital of the University of Pennsylvania (J.A.C., S.V.S., J.S.M., D.J.R., B.F., J.B., K.B.M., T.P.C.). From the Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN (K.C.V.); and Department of Medicine, Institute for Translational Medicine and Therapeutics and Cardiovascular Institute, Perelman School of Medicine of the University of Pennsylvania, Philadelphia, PA (D.J.R.). Lipid Research Group, The Heart Research Institute, Camperdown, Sydney, NSW 2050, Australia, and Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 Pathology and Molecular Disease Branches, National Heart, Lung, and Blood Institute, National Institutes of Health. Bethesda, Maryland. Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Division of Cardiovascular Medicine, Department of Medicine, University of Pennsylvania Health System, Philadelphia, PA, USA; Translational Medicine and Human Genetics, Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA From the Department of Medicine (F.F.S., P.O.S., M.M.W., A.K., D.J.R.), Cardiovascular Division, and the Cardiovascular Institute, University of Pennsylvania Medical Center; The Philadelphia Veterans Affairs Medical Center (F.F.S., N.I., M.M.W.); The Institute for Translational Medicine and Therapeutics (F.F.S., P.O.S., L.T.B., M.L.W., D.J.R.), University of Pennsylvania, Philadelphia. Current affiliation for P.O.S. is Wyeth Research, Collegeville, Pa. From Departments of Genetics, Medicine, and Pediatrics and Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia. From Cardiology Division and Center for Genomic Medicine, Massachusetts General Hospital, Boston (A.V.K.); Harvard Medical School, Boston, MA (A.V.K., O.V.D., P.MR., S.M.); Center for Lipid Metabolomics and Division of Preventive Medicine (A.V.K., O.V.D., R.J.G., P.MR., S.M.), Division of Cardiovascular Medicine (P.MR., S.M.), Brigham and Women’s Hospital, Boston, MA; Vascular Strategies, Plymouth Meeting, PA (S.J.A., H.L.C.); and Department of Genetics, University of Pennsylvania, Philadelphia (D.J... Department of Medicine and Department of Genetics, Cardiovascular Institute, and Institute for Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Department of Genetics and Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia (L.E.L., P.L.W.C., N.J.H., D.J.R.). From the Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA (S.T., S.A.F., P.N., J.D.B., T.M., J.P.); Division of Translational Medicine and Human Genetics, University of Pennsylvania, Philadelphia, PA (D.J.R.); and Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA (A.S.). Department of Genetics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia; Cardiovascular Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia Department of Genetics, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Institute for Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA From the Cardiovascular Division and Center for Experimental Therapeutics, Department of Medicine, University of Pennsylvania School of Medicine (M.P.R., M.L.W., N.M., D.J.R.), and the Department of Epidemiology, Merck Research Laboratories (T.R., C.G.), Philadelphia, Pa. From the Departments of Medicine (C.M., U.J.F.T., U.C.B., D.M., D.J.R.) and Cell and Developmental Biology (M.G.M., J.M.G.), University of Pennsylvania, Philadelphia, Pa; Department of Biology (W.C.), University of Delaware, Newark, Del; and Children’s Hospital of Philadelphia (S.L.K.), Philadelphia, Pa. From the Department of Medicine (K.N., J.T., S.U.N., H.T., J.T.B., D.J.R.) and Institute for Translational Medicine and Therapeutics (K.N., J.T., S.U.N., H.T., J.T.B., D.J.R.), University of Pennsylvania School of Medicine, Philadelphia, PA; GlaxoSmithKline, Upper Merion, PA (C.M.). Division of Cardiology, Department of Medicine, Hospital of the University of Pennsylvania University of Pennsylvania School of Medicine Philadelphia PA USA Department of Medicine, Perelman School of Medicine of the University of Pennsylvania, Philadelphia, PA, USA From the Department of Medicine (U.J.F.T., C.M., D.J.R.), University of Pennsylvania School of Medicine, and Children’s Hospital of Philadelphia (S.L.-K.), Philadelphia, Pa; Xenogen Corp (D.G.), Cranbury, NJ; and the University of Kentucky (F.C.dB.), Lexington. Department of Medicine (M.G.L., K.-M.C., D.J.R.), University of Pennsylvania Perelman School of Medicine, Philadelphia.; Institute for Translational Medicine and Therapeutics (D.J.R., B.F.V.), University of Pennsylvania Perelman School of Medicine, Philadelphia.; Department of Genetics (D.J.R., B.V.F.), University of Pennsylvania Perelman School of Medicine, Philadelphia.; Munich Cluster for Systems Neurology (SyNergy), Germany (D.J.R., B.F.V.). Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: rader@mail.med.upenn.edu. Institute for Translational Medicine and Therapeutics and Cardiovascular Institute, University of Pennsylvania School of Medicine From the Molecular Disease Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md. Institute for Translational Medicine and Therapeutics (K.O.B., D.J.R.), School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104 Department of Medicine, Cardiovascular Disease Division, University of Pennsylvania School of Medicine, Philadelphia, PA, USA From the Department of Medicine and Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine, Philadelphia. Division of Translational Medicine & Human Genetics, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, PA, USA; ll–125 Smilow Center for Translational Research, 3400 Civic Center Boulevard, Building 421, PA 19104–5158, USA From the Renal, Electrolyte, and Hypertension Division, Department of Medicine, Perelman School of Medicine (J.L.), Department of Biostatistics and Epidemiology (Y.H., M.L.), Department of Genetics, Perelman School of Medicine (B.C., K.M., D.J.R.), and Cardiovascular Institute, Department of Medicine, Perelman School of Medicine (M.G., W.L., K.M.), University of Pennsylvania, Philadelphia; Irving Institute for Clinical and Translational Research (M.P.R.) and Division of Cardiology, Department of... Department of Medicine Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.; Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.; Department of Genetics Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Departments of Medicine and Pharmacology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104. Departments of Medicine and Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104;, Department of Medicine; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA From the Institute for Translational Medicine and Therapeutics and Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia (H.T., J.T.B., J.-i.T., N.F., D.J.R.); Department of Medicine, St Michael’s Hospital, Toronto, Canada (D.S.N.); and Children’s Hospital of Philadelphia, Philadelphia, Pa (G.H.R.). Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Institute for Translational Medicine and Therapeutics, Perelman School of Medicine University of Pennsylvania Philadelphia PA 19104 USA From Perelman School of Medicine at the University of Pennsylvania, Philadelphia (R.C.B., J.T., J.C., L.C., J.Y., X.Z., K.O., G.K.P., M.S.P., D.J.R., M.P.R.); Division of Translational Medicine and Human Genetics, Philadelphia, PA (R.C.B., J.T., D..J.R.); The Cardiovascular Institute, Philadelphia, PA (J.C., L.C., J.Y., X.Z., K.O., M.S.P., D.J.R., M.P.R.); Institute of Translational Medicine and Therapeutics, Philadelphia, PA (G.K.P., D.J.R.); Department of Genetics, Philadelphia, PA (D.J.R); and... Perelman School of Medicine at the University of Pennsylvania, Division of Translational Medicine & Human Genetics, 11-125 Translational Research Center, 3400 Civic Center Blvd, Building 421, Philadelphia, PA 19104-5158, USA. From the Department of Medicine, Division of Endocrinology, University of Toronto, Toronto, Canada (S.R., D.K.T., K.D.U., G.F.L.); the Hyperlipidemia and Atherosclerosis Research Group, Montreal, Quebec, Canada (J.S.C.); and the Department of Medicine, University of Pennsylvania, Philadelphia (D.J.R.). From the Department of Medicine, Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia (A.Q., S.A.K., D.J.R., M.P.R.); Cardiology Division, Department of Medicine, Massachusetts General Hospital, Boston (A.V.K.); and Division of Cardiology, Department of Medicine, University of California at San Francisco (A.Q.). From the Department of Medicine and Cardiovascular Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia (N.M., A.Q., L.Q., M.P.R., D.J.R.); Department of Medicine, University of California at San Francisco (A.N.Q.); and National Heart, Lung, and Blood Institute, Bethesda, MD (N.N.M.) From the Center for Experimental Therapeutics and Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pa. Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia |
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Total number of triples: 1027.