http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108586251-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2601-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2601-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2602-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2601-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2603-32 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C69-78 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D311-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C69-738 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D337-14 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C69-78 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C69-738 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D337-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C67-343 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D311-22 |
| filingDate | 2018-06-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-01-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-01-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108586251-B |
| titleOfInvention | Preparation method of benzoyl para-difluoroalkylated derivative |
| abstract | The invention discloses a preparation method of benzoyl para-difluoroalkylated derivative, which comprises the steps of sequentially adding benzoyl derivative, palladium tetratriphenylphosphine, potassium acetate, triphenylphosphine, silver fluoride (I) and ethyl bromodifluoroacetate into a glass reaction tube, taking n-hexane or 1, 4-dioxane as a solvent, adopting inert gas for protection, and reacting at 120-140 ℃ to obtain the benzoyl para-difluoroalkylated derivative. The invention uses benzoyl derivative as the starting material, the raw material is easy to obtain, and the variety is wide; the products obtained by the method of the invention have various types, can be directly applied to the synthesis of drug molecules, and can also be used for other further reactions; meanwhile, the synthesis route is safe and easy to implement, the cost is low, the reaction operation and the post-treatment process are simple, the selectivity is good, the side reaction is less, and the large-scale reaction can be carried out. |
| priorityDate | 2018-06-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 121.